lactic acid has been researched along with Plasmodium falciparum Malaria in 30 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fifty-six adult patients with severe malaria and high parasitemia admitted to a referral hospital in Bangladesh were randomized to receive a single dose of levamisole hydrochloride (150 mg) or no adjuvant to antimalarial treatment with intravenous artesunate." | 9.19 | Randomized controlled trial of levamisole hydrochloride as adjunctive therapy in severe falciparum malaria with high parasitemia. ( Abul Faiz, M; Bin Yunus, E; Charunwatthana, P; Chotivanich, K; Day, NP; Dondorp, AM; Eastaugh, A; Ghose, A; Hanson, J; Hassan, MU; Ho, M; Hoque, G; Hossain, MA; Islam, F; Lacey, R; Lee, SJ; Maude, RJ; Plewes, K; Rahman, R; Schlatter, J; Silamut, K; Tarning, J; White, NJ, 2014) |
| " Plasmodium falciparum infection can cause severe malaria anaemia (SMA) with insufficient tissue oxygenation, lactic acidosis and death." | 7.88 | Mitochondrial gene sequence variants in children with severe malaria anaemia with or without lactic acidosis: a case control study. ( Amr, SS; Cserti-Gazdewich, C; Dhabangi, A; Dzik, W; Fowler, C; Musoke, C; Sharma, H, 2018) |
| "Fifty-six adult patients with severe malaria and high parasitemia admitted to a referral hospital in Bangladesh were randomized to receive a single dose of levamisole hydrochloride (150 mg) or no adjuvant to antimalarial treatment with intravenous artesunate." | 5.19 | Randomized controlled trial of levamisole hydrochloride as adjunctive therapy in severe falciparum malaria with high parasitemia. ( Abul Faiz, M; Bin Yunus, E; Charunwatthana, P; Chotivanich, K; Day, NP; Dondorp, AM; Eastaugh, A; Ghose, A; Hanson, J; Hassan, MU; Ho, M; Hoque, G; Hossain, MA; Islam, F; Lacey, R; Lee, SJ; Maude, RJ; Plewes, K; Rahman, R; Schlatter, J; Silamut, K; Tarning, J; White, NJ, 2014) |
| "Children with severe malaria often present with lactic acidosis and hypoglycemia." | 5.09 | Glucose and lactate kinetics in children with severe malaria. ( Agbenyega, T; Angus, BJ; Baffoe-Bonnie, B; Bedu-Addo, G; Guyton, T; Krishna, S; Stacpoole, PW, 2000) |
| "Amino acid derangements are common in severe falciparum malaria and have been associated with endothelial dysfunction (L-arginine), metabolic acidosis (alanine and lactate), and disease severity (phenylalanine and tryptophan metabolites)." | 3.91 | Amino acid derangements in adults with severe falciparum malaria. ( Apinan, S; Barua, A; Day, NPJ; Dondorp, AM; Dutta, AK; Ghose, A; Hossain, A; Kingston, HW; Leopold, SJ; Paul, S; Plewes, KA; Sattar, A; Tarning, J; White, NJ; Winterberg, M, 2019) |
| " Plasmodium falciparum infection can cause severe malaria anaemia (SMA) with insufficient tissue oxygenation, lactic acidosis and death." | 3.88 | Mitochondrial gene sequence variants in children with severe malaria anaemia with or without lactic acidosis: a case control study. ( Amr, SS; Cserti-Gazdewich, C; Dhabangi, A; Dzik, W; Fowler, C; Musoke, C; Sharma, H, 2018) |
| "Recovery of endothelial function in severe malaria is associated with recovery from hypoargininemia and lactic acidosis." | 3.74 | Recovery of endothelial function in severe falciparum malaria: relationship with improvement in plasma L-arginine and blood lactate concentrations. ( Anstey, NM; Celermajer, DS; Darcy, CJ; Duffull, SB; Gitawati, R; Granger, DL; Kenangalem, E; Lampah, DA; Lopansri, BK; McNeil, YR; Price, RN; Tjitra, E; Weinberg, JB; Yeo, TW, 2008) |
| "Development of hypotensive shock or pulmonary edema within 24 hours after enrollment were not related to the volume of fluid administration." | 1.56 | Associations Between Restrictive Fluid Management and Renal Function and Tissue Perfusion in Adults With Severe Falciparum Malaria: A Prospective Observational Study. ( Alam, S; Charunwatthana, P; Day, NPJ; Dey, C; Dondorp, AM; Faiz, MA; Ghose, A; Herdman, MT; Hossain, MA; Ishioka, H; Kingston, HWF; Leopold, SJ; Mahanta, K; Maude, RJ; Mohanty, A; Mohanty, S; Pattnaik, R; Plewes, K; Srinamon, K; White, NJ, 2020) |
| "Severe falciparum malaria is commonly complicated by metabolic acidosis." | 1.42 | The role of previously unmeasured organic acids in the pathogenesis of severe malaria. ( Charunwatthana, P; Chotinavich, K; Day, NP; Dondorp, AM; Douthwaite, S; Faiz, MA; Ghose, A; Hassan, MM; Herdman, MT; Hossain, MA; Kingston, HW; Leepipatpiboon, N; Leopold, SJ; Maude, RJ; Mishra, S; Mohanty, S; Plewes, K; Silamut, K; Sriboonvorakul, N; Tarning, J; White, NJ; Woodrow, CJ, 2015) |
| "Lactic acidosis is a consistent predictor of mortality owing to severe infectious disease, but its detection in low-income settings is limited to the clinical sign of "deep breathing" because of the lack of accessible technology for its measurement." | 1.37 | Point-of-care measurement of blood lactate in children admitted with febrile illness to an African District Hospital. ( Amos, B; Hendriksen, IC; Mtove, G; Muro, F; Nadjm, B; Reyburn, H; Todd, J, 2011) |
| "Children with coma and respiratory distress (CM + RD) had greater evidence of renal dysfunction, lower mean pH and higher mean plasma osmolality than those with respiratory distress (RD) or coma (CM) as isolated findings (mean urea 10." | 1.30 | Acidosis in severe childhood malaria. ( English, M; Lowe, B; Marsh, K; Mosobo, M; Obiero, J; Sauerwein, R; Waruiru, C, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (20.00) | 18.2507 |
| 2000's | 10 (33.33) | 29.6817 |
| 2010's | 10 (33.33) | 24.3611 |
| 2020's | 4 (13.33) | 2.80 |
| Authors | Studies |
|---|---|
| Peng, X | 1 |
| Wang, N | 1 |
| Zhu, A | 1 |
| Xu, H | 1 |
| Li, J | 1 |
| Zhou, Y | 1 |
| Wang, C | 1 |
| Xiao, Q | 1 |
| Guo, L | 1 |
| Liu, F | 1 |
| Jia, ZJ | 1 |
| Duan, H | 1 |
| Hu, J | 1 |
| Yuan, W | 1 |
| Geng, J | 1 |
| Yan, C | 1 |
| Jiang, X | 1 |
| Deng, D | 1 |
| Anagu, LO | 1 |
| Hulse, DR | 1 |
| Horrocks, PD | 1 |
| Chakravorty, SJ | 1 |
| Ishioka, H | 1 |
| Plewes, K | 3 |
| Pattnaik, R | 1 |
| Kingston, HWF | 1 |
| Leopold, SJ | 3 |
| Herdman, MT | 2 |
| Mahanta, K | 1 |
| Mohanty, A | 2 |
| Dey, C | 1 |
| Alam, S | 1 |
| Srinamon, K | 1 |
| Maude, RJ | 3 |
| White, NJ | 8 |
| Day, NPJ | 2 |
| Hossain, MA | 3 |
| Faiz, MA | 2 |
| Charunwatthana, P | 3 |
| Mohanty, S | 2 |
| Ghose, A | 4 |
| Dondorp, AM | 5 |
| West, R | 1 |
| Sullivan, DJ | 1 |
| Fowler, C | 1 |
| Cserti-Gazdewich, C | 1 |
| Dhabangi, A | 1 |
| Musoke, C | 1 |
| Sharma, H | 1 |
| Amr, SS | 1 |
| Dzik, W | 1 |
| Apinan, S | 1 |
| Kingston, HW | 2 |
| Plewes, KA | 1 |
| Hossain, A | 1 |
| Dutta, AK | 1 |
| Paul, S | 1 |
| Barua, A | 1 |
| Sattar, A | 1 |
| Tarning, J | 3 |
| Winterberg, M | 1 |
| Cunnington, AJ | 1 |
| Bretscher, MT | 1 |
| Nogaro, SI | 1 |
| Riley, EM | 1 |
| Walther, M | 2 |
| Silamut, K | 2 |
| Ho, M | 1 |
| Abul Faiz, M | 1 |
| Rahman, R | 1 |
| Hassan, MU | 1 |
| Bin Yunus, E | 1 |
| Hoque, G | 1 |
| Islam, F | 1 |
| Hanson, J | 1 |
| Schlatter, J | 1 |
| Lacey, R | 1 |
| Eastaugh, A | 1 |
| Lee, SJ | 1 |
| Chotivanich, K | 1 |
| Day, NP | 4 |
| Wu, B | 1 |
| Rambow, J | 1 |
| Bock, S | 1 |
| Holm-Bertelsen, J | 1 |
| Wiechert, M | 1 |
| Soares, AB | 1 |
| Spielmann, T | 1 |
| Beitz, E | 1 |
| Kumar, R | 1 |
| Ledet, G | 1 |
| Graves, R | 1 |
| Datta, D | 1 |
| Robinson, S | 1 |
| Bansal, GP | 1 |
| Mandal, T | 1 |
| Kumar, N | 1 |
| Sriboonvorakul, N | 1 |
| Douthwaite, S | 1 |
| Hassan, MM | 1 |
| Woodrow, CJ | 1 |
| Chotinavich, K | 1 |
| Mishra, S | 1 |
| Leepipatpiboon, N | 1 |
| Yeo, TW | 1 |
| Lampah, DA | 1 |
| Gitawati, R | 1 |
| Tjitra, E | 1 |
| Kenangalem, E | 1 |
| McNeil, YR | 1 |
| Darcy, CJ | 1 |
| Granger, DL | 1 |
| Weinberg, JB | 1 |
| Lopansri, BK | 1 |
| Price, RN | 1 |
| Duffull, SB | 1 |
| Celermajer, DS | 1 |
| Anstey, NM | 1 |
| te Witt, R | 1 |
| van Wolfswinkel, ME | 1 |
| Petit, PL | 1 |
| van Hellemond, JJ | 1 |
| Koelewijn, R | 1 |
| van Belkum, A | 1 |
| van Genderen, PJ | 1 |
| Mtove, G | 1 |
| Nadjm, B | 1 |
| Hendriksen, IC | 1 |
| Amos, B | 1 |
| Muro, F | 1 |
| Todd, J | 1 |
| Reyburn, H | 1 |
| Merrick, CJ | 1 |
| Huttenhower, C | 1 |
| Buckee, C | 1 |
| Amambua-Ngwa, A | 1 |
| Gomez-Escobar, N | 1 |
| Conway, DJ | 1 |
| Duraisingh, MT | 1 |
| Duranton, C | 1 |
| Huber, SM | 1 |
| Tanneur, V | 1 |
| Brand, VB | 1 |
| Akkaya, C | 1 |
| Shumilina, EV | 1 |
| Sandu, CD | 1 |
| Lang, F | 1 |
| van Thien, H | 1 |
| Weverling, GJ | 1 |
| Ackermans, MT | 1 |
| canh Hung, N | 1 |
| Endert, E | 2 |
| Kager, PA | 1 |
| Sauerwein, HP | 2 |
| Chau, TT | 2 |
| Phu, NH | 2 |
| Mai, NT | 2 |
| Loc, PP | 2 |
| Chuong, LV | 2 |
| Sinh, DX | 2 |
| Taylor, A | 1 |
| Hien, TT | 2 |
| Newton, CR | 2 |
| Valim, C | 1 |
| Krishna, S | 2 |
| Wypij, D | 1 |
| Olola, C | 1 |
| Agbenyega, T | 2 |
| Taylor, TE | 1 |
| Casals-Pascual, C | 1 |
| Kai, O | 1 |
| Lowe, B | 2 |
| English, M | 2 |
| Williams, TN | 1 |
| Maitland, K | 1 |
| Peshu, N | 2 |
| Roberts, DJ | 1 |
| Pukrittayakamee, S | 2 |
| Davis, TM | 2 |
| Supanaranond, W | 2 |
| Crawley, J | 1 |
| Nagachinta, B | 1 |
| Williamson, DH | 2 |
| Lando, G | 1 |
| Djiogue, R | 1 |
| Djoumessi, S | 1 |
| Joynt, G | 1 |
| Doedens, L | 1 |
| Lipman, J | 1 |
| Bothma, P | 1 |
| Dekker, E | 1 |
| Hellerstein, MK | 1 |
| Romijn, JA | 1 |
| Neese, RA | 1 |
| Marsh, K | 2 |
| Sauerwein, R | 1 |
| Waruiru, C | 1 |
| Mosobo, M | 1 |
| Obiero, J | 1 |
| Angus, BJ | 1 |
| Bedu-Addo, G | 1 |
| Baffoe-Bonnie, B | 1 |
| Guyton, T | 1 |
| Stacpoole, PW | 1 |
| Holloway, P | 1 |
| Elliott, JL | 1 |
| Saliba, KJ | 1 |
| Kirk, K | 1 |
| Rosas, JE | 1 |
| Pedraz, JL | 1 |
| Hernández, RM | 1 |
| Gascón, AR | 1 |
| Igartua, M | 1 |
| Guzmán, F | 1 |
| Rodríguez, R | 1 |
| Cortés, J | 1 |
| Patarroyo, ME | 1 |
| Looareesuwan, S | 1 |
| Desakorn, V | 1 |
| Chaivisuth, B | 1 |
4 trials available for lactic acid and Plasmodium falciparum Malaria
| Article | Year |
|---|---|
Randomized controlled trial of levamisole hydrochloride as adjunctive therapy in severe falciparum malaria with high parasitemia.
Topics: Adult; Antimalarials; Female; Humans; Kaplan-Meier Estimate; Lactic Acid; Levamisole; Malaria, Falci | 2014 |
FFAs are not involved in regulation of gluconeogenesis and glycogenolysis in adults with uncomplicated P. falciparum malaria.
Topics: Adult; Alanine; Fatty Acids, Nonesterified; Female; Gluconeogenesis; Glucose; Glycogen; Humans; Hypo | 2004 |
Unidentified acids of strong prognostic significance in severe malaria.
Topics: Acid-Base Equilibrium; Acidosis; Adolescent; Adult; Aged; Cohort Studies; Creatinine; Critical Care; | 2004 |
Glucose and lactate kinetics in children with severe malaria.
Topics: Acidosis, Lactic; Antimalarials; Artemisinins; Artesunate; Blood Glucose; Child; Child, Preschool; D | 2000 |
26 other studies available for lactic acid and Plasmodium falciparum Malaria
| Article | Year |
|---|---|
Structural characterization of the Plasmodium falciparum lactate transporter PfFNT alone and in complex with antimalarial compound MMV007839 reveals its inhibition mechanism.
Topics: Antimalarials; Cryoelectron Microscopy; Formates; Lactic Acid; Malaria, Falciparum; Monocarboxylic A | 2021 |
Alteration of the expression of sirtuins and var genes by heat shock in the malaria parasite Plasmodium falciparum.
Topics: Animals; Heat-Shock Response; Humans; Kenya; Lactic Acid; Malaria, Falciparum; Parasites; Plasmodium | 2022 |
Associations Between Restrictive Fluid Management and Renal Function and Tissue Perfusion in Adults With Severe Falciparum Malaria: A Prospective Observational Study.
Topics: Acute Kidney Injury; Adult; Female; Fluid Therapy; Humans; Kidney Function Tests; Lactic Acid; Malar | 2020 |
Lactic Acid Supplementation Increases Quantity and Quality of Gametocytes in Plasmodium falciparum Culture.
Topics: Animals; Anopheles; Dietary Supplements; Gene Expression; Genes, Reporter; Humans; Lactic Acid; Mala | 2020 |
Mitochondrial gene sequence variants in children with severe malaria anaemia with or without lactic acidosis: a case control study.
Topics: Acidosis, Lactic; Anemia; Case-Control Studies; Child, Preschool; DNA, Mitochondrial; Female; Humans | 2018 |
Amino acid derangements in adults with severe falciparum malaria.
Topics: Acidosis; Adult; Amino Acids; Arginine; Bangladesh; Female; Humans; Lactic Acid; Malaria, Falciparum | 2019 |
Comparison of parasite sequestration in uncomplicated and severe childhood Plasmodium falciparum malaria.
Topics: Antigens, Protozoan; Case-Control Studies; Child; Child, Preschool; Erythrocytes; Female; Humans; La | 2013 |
Identity of a Plasmodium lactate/H(+) symporter structurally unrelated to human transporters.
Topics: Animals; Biological Transport; Cell Membrane; Erythrocytes; Fluorescence; Glycolysis; Green Fluoresc | 2015 |
Potent Functional Immunogenicity of Plasmodium falciparum Transmission-Blocking Antigen (Pfs25) Delivered with Nanoemulsion and Porous Polymeric Nanoparticles.
Topics: Animals; Antibody Formation; Emulsions; Female; Immunization; Lactic Acid; Malaria Vaccines; Malaria | 2015 |
The role of previously unmeasured organic acids in the pathogenesis of severe malaria.
Topics: 3-Hydroxybutyric Acid; Acidosis; Adolescent; Adult; Aged; Chromatography, Liquid; Female; Humans; Hy | 2015 |
Recovery of endothelial function in severe falciparum malaria: relationship with improvement in plasma L-arginine and blood lactate concentrations.
Topics: Acidosis; Adult; Arginine; Biological Availability; Endothelium, Vascular; Humans; Lactic Acid; Mala | 2008 |
Neopterin and procalcitonin are suitable biomarkers for exclusion of severe Plasmodium falciparum disease at the initial clinical assessment of travellers with imported malaria.
Topics: Adolescent; Adult; Aged; Biomarkers; Calcitonin; Calcitonin Gene-Related Peptide; Child; Female; Hum | 2010 |
Point-of-care measurement of blood lactate in children admitted with febrile illness to an African District Hospital.
Topics: Adolescent; Anemia; Bacterial Infections; Child; Child, Preschool; Cohort Studies; Female; Fever; Ho | 2011 |
Epigenetic dysregulation of virulence gene expression in severe Plasmodium falciparum malaria.
Topics: Epigenomics; Gene Expression; Gene Knockout Techniques; Host-Parasite Interactions; Humans; Lactic A | 2012 |
Organic osmolyte permeabilities of the malaria-induced anion conductances in human erythrocytes.
Topics: Animals; Anions; Erythrocytes; Humans; Hypertonic Solutions; Hypotonic Solutions; Isotonic Solutions | 2004 |
The prognostic value of measures of acid/base balance in pediatric falciparum malaria, compared with other clinical and laboratory parameters.
Topics: Acid-Base Equilibrium; Acidosis; Adolescent; Child; Child, Preschool; Female; Ghana; Humans; Infant; | 2005 |
Lactate levels in severe malarial anaemia are associated with haemozoin-containing neutrophils and low levels of IL-12.
Topics: Anemia; Child, Preschool; Female; Hemeproteins; Humans; Infant; Interleukin-12; Kenya; Lactic Acid; | 2006 |
Glycerol metabolism in severe falciparum malaria.
Topics: Adolescent; Adult; Blood Glucose; Female; Galactose; Glycerol; Humans; Indocyanine Green; Kinetics; | 1994 |
[Prognostic value of lactate determination in cerebral malaria in the Cameroonian child].
Topics: Adolescent; Cameroon; Child; Child, Preschool; Female; Humans; Infant; Insulin; Lactates; Lactic Aci | 1995 |
High-dose adrenaline with low systemic vascular resistance and symmetrical peripheral gangrene.
Topics: Adult; Cardiac Output; Epinephrine; Gangrene; Humans; Hypotension; Lactic Acid; Malaria, Falciparum; | 1996 |
Glucose homeostasis in children with falciparum malaria: precursor supply limits gluconeogenesis and glucose production.
Topics: Alanine; Blood Glucose; Child; Child, Preschool; Cytokines; Deuterium; Female; Gluconeogenesis; Gluc | 1997 |
Acidosis in severe childhood malaria.
Topics: Acidosis; Age Factors; Child, Preschool; Coma; Female; Hemoglobins; Humans; Infant; Lactic Acid; Mal | 1997 |
The pathophysiologic and prognostic significance of acidosis in severe adult malaria.
Topics: Acidosis; Adolescent; Adult; Aged; Cohort Studies; Female; Hepatic Veins; Humans; Lactic Acid; Malar | 2000 |
Transport of lactate and pyruvate in the intraerythrocytic malaria parasite, Plasmodium falciparum.
Topics: Animals; Anion Transport Proteins; Biological Transport; Carrier Proteins; Erythrocytes; Glycolysis; | 2001 |
Remarkably high antibody levels and protection against P. falciparum malaria in Aotus monkeys after a single immunisation of SPf66 encapsulated in PLGA microspheres.
Topics: Alum Compounds; Animals; Antibodies, Protozoan; Antigens, Protozoan; Aotus trivirgatus; Biocompatibl | 2002 |
Hepatic blood flow and metabolism in severe falciparum malaria: clearance of intravenously administered galactose.
Topics: Acute Disease; Adolescent; Adult; Animals; Blood Glucose; Female; Galactose; Humans; Lactates; Lacti | 1992 |