Page last updated: 2024-10-17

lactic acid and Placental Insufficiency

lactic acid has been researched along with Placental Insufficiency in 9 studies

Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.

Placental Insufficiency: Failure of the PLACENTA to deliver an adequate supply of nutrients and OXYGEN to the FETUS.

Research Excerpts

ExcerptRelevanceReference
"We hypothesized that ephedrine and phenylephrine are equal with respect to uterine and placental haemodynamics and fetal acid-base status after exposure to maternal hypoxaemia and hypotension in a chronic sheep model of increased placental vascular resistance (R(UA))."7.73Ephedrine and phenylephrine for the treatment of maternal hypotension in a chronic sheep model of increased placental vascular resistance. ( Acharya, G; Alahuhta, S; Erkinaro, T; Kavasmaa, T; Mäkikallio, K; Päkkilä, M; Räsänen, J, 2006)
"We hypothesized that ephedrine and phenylephrine are equal with respect to uterine and placental haemodynamics and fetal acid-base status after exposure to maternal hypoxaemia and hypotension in a chronic sheep model of increased placental vascular resistance (R(UA))."3.73Ephedrine and phenylephrine for the treatment of maternal hypotension in a chronic sheep model of increased placental vascular resistance. ( Acharya, G; Alahuhta, S; Erkinaro, T; Kavasmaa, T; Mäkikallio, K; Päkkilä, M; Räsänen, J, 2006)
"During placental insufficiency-induced intrauterine growth restriction (PI-IUGR), uteroplacental weight-specific oxygen consumption rates are maintained, yet fetal glucose and amino acid supply is decreased and fetal lactate concentrations are increased."1.91Adaptive responses in uteroplacental metabolism and fetoplacental nutrient shuttling and sensing during placental insufficiency. ( Brown, LD; Julian, CG; Kyllo, HM; Lorca, RA; Moore, LG; Rozance, PJ; Wang, D; Wesolowski, SR; Wilkening, RB, 2023)
"While utero-placental insufficiency is associated with adverse outcomes for both mother and fetus, many of the maternal-fetal adaptations during pregnancy in models of fetal compromise remain unclear."1.38Circulating and utero-placental adaptations to chronic placental ischemia in the rat. ( Banek, CT; Bauer, AJ; Chasson, S; Gilbert, JS; Gingery, A, 2012)
"Nutritional interventions for intrauterine growth restriction (IUGR) have raised concerns for fetal toxicity, the mechanisms of which are unknown."1.35Glucose replacement to euglycemia causes hypoxia, acidosis, and decreased insulin secretion in fetal sheep with intrauterine growth restriction. ( Barry, JS; Brown, LD; Hay, WW; Limesand, SW; Rozance, PJ, 2009)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (55.56)29.6817
2010's3 (33.33)24.3611
2020's1 (11.11)2.80

Authors

AuthorsStudies
Kyllo, HM1
Wang, D1
Lorca, RA1
Julian, CG1
Moore, LG1
Wilkening, RB1
Rozance, PJ3
Brown, LD2
Wesolowski, SR1
Limesand, SW2
Barry, JS1
Hay, WW2
Charles-Edwards, GD1
Jan, W1
To, M1
Maxwell, D1
Keevil, SF1
Robinson, R1
Gilbert, JS1
Bauer, AJ1
Gingery, A1
Banek, CT1
Chasson, S1
Junno, J1
Bruun, E1
Gutierrez, JH1
Erkinaro, T3
Haapsamo, M2
Acharya, G3
Räsänen, J3
Kavasmaa, T2
Päkkilä, M1
Mäkikallio, K2
Alahuhta, S1
Smith, D1
Mertens, L1
Huhta, JC1
Gagnon, R1
Harding, R1
Brace, RA1

Other Studies

9 other studies available for lactic acid and Placental Insufficiency

ArticleYear
Adaptive responses in uteroplacental metabolism and fetoplacental nutrient shuttling and sensing during placental insufficiency.
    American journal of physiology. Endocrinology and metabolism, 2023, 06-01, Volume: 324, Issue:6

    Topics: Amino Acids; AMP-Activated Protein Kinases; Animals; Female; Fetal Growth Retardation; Fetus; Glucos

2023
Glucose replacement to euglycemia causes hypoxia, acidosis, and decreased insulin secretion in fetal sheep with intrauterine growth restriction.
    Pediatric research, 2009, Volume: 65, Issue:1

    Topics: Acidosis; Amino Acids; Animals; Blood Glucose; Carbon Dioxide; Disease Models, Animal; Down-Regulati

2009
Non-invasive detection and quantification of human foetal brain lactate in utero by magnetic resonance spectroscopy.
    Prenatal diagnosis, 2010, Volume: 30, Issue:3

    Topics: Adult; Biomarkers; Brain; Brain Chemistry; Female; Fetal Growth Retardation; Fetal Hypoxia; Fetus; H

2010
Circulating and utero-placental adaptations to chronic placental ischemia in the rat.
    Placenta, 2012, Volume: 33, Issue:2

    Topics: Adaptation, Physiological; Animals; Female; Fetal Development; Fetal Growth Retardation; Fetus; Insu

2012
Fetal sheep left ventricle is more sensitive than right ventricle to progressively worsening hypoxemia and acidemia.
    European journal of obstetrics, gynecology, and reproductive biology, 2013, Volume: 167, Issue:2

    Topics: Acidosis; Animals; Animals, Inbred Strains; Disease Models, Animal; Disease Progression; Female; Fin

2013
Ephedrine and phenylephrine for the treatment of maternal hypotension in a chronic sheep model of increased placental vascular resistance.
    British journal of anaesthesia, 2006, Volume: 96, Issue:2

    Topics: Anesthesia, Epidural; Anesthesia, Obstetrical; Animals; Disease Models, Animal; Ephedrine; Female; H

2006
Increased insulin sensitivity and maintenance of glucose utilization rates in fetal sheep with placental insufficiency and intrauterine growth restriction.
    American journal of physiology. Endocrinology and metabolism, 2007, Volume: 293, Issue:6

    Topics: Animals; Blood Glucose; Cyclic AMP Response Element-Binding Protein; Female; Fetal Growth Retardatio

2007
Metabolic acidosis decreases fetal myocardial isovolumic velocities in a chronic sheep model of increased placental vascular resistance.
    American journal of physiology. Heart and circulatory physiology, 2008, Volume: 294, Issue:1

    Topics: Acidosis; Acute Disease; Animals; Blood Pressure; Cardiac Output; Central Venous Pressure; Chronic D

2008
Amniotic fluid and fetal urinary responses to severe placental insufficiency in sheep.
    American journal of obstetrics and gynecology, 2002, Volume: 186, Issue:5

    Topics: Amniotic Fluid; Animals; Arteries; Body Water; Embryonic and Fetal Development; Female; Fetus; Gesta

2002