lactic acid has been researched along with Placental Insufficiency in 9 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Placental Insufficiency: Failure of the PLACENTA to deliver an adequate supply of nutrients and OXYGEN to the FETUS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We hypothesized that ephedrine and phenylephrine are equal with respect to uterine and placental haemodynamics and fetal acid-base status after exposure to maternal hypoxaemia and hypotension in a chronic sheep model of increased placental vascular resistance (R(UA))." | 7.73 | Ephedrine and phenylephrine for the treatment of maternal hypotension in a chronic sheep model of increased placental vascular resistance. ( Acharya, G; Alahuhta, S; Erkinaro, T; Kavasmaa, T; Mäkikallio, K; Päkkilä, M; Räsänen, J, 2006) |
| "We hypothesized that ephedrine and phenylephrine are equal with respect to uterine and placental haemodynamics and fetal acid-base status after exposure to maternal hypoxaemia and hypotension in a chronic sheep model of increased placental vascular resistance (R(UA))." | 3.73 | Ephedrine and phenylephrine for the treatment of maternal hypotension in a chronic sheep model of increased placental vascular resistance. ( Acharya, G; Alahuhta, S; Erkinaro, T; Kavasmaa, T; Mäkikallio, K; Päkkilä, M; Räsänen, J, 2006) |
| "During placental insufficiency-induced intrauterine growth restriction (PI-IUGR), uteroplacental weight-specific oxygen consumption rates are maintained, yet fetal glucose and amino acid supply is decreased and fetal lactate concentrations are increased." | 1.91 | Adaptive responses in uteroplacental metabolism and fetoplacental nutrient shuttling and sensing during placental insufficiency. ( Brown, LD; Julian, CG; Kyllo, HM; Lorca, RA; Moore, LG; Rozance, PJ; Wang, D; Wesolowski, SR; Wilkening, RB, 2023) |
| "While utero-placental insufficiency is associated with adverse outcomes for both mother and fetus, many of the maternal-fetal adaptations during pregnancy in models of fetal compromise remain unclear." | 1.38 | Circulating and utero-placental adaptations to chronic placental ischemia in the rat. ( Banek, CT; Bauer, AJ; Chasson, S; Gilbert, JS; Gingery, A, 2012) |
| "Nutritional interventions for intrauterine growth restriction (IUGR) have raised concerns for fetal toxicity, the mechanisms of which are unknown." | 1.35 | Glucose replacement to euglycemia causes hypoxia, acidosis, and decreased insulin secretion in fetal sheep with intrauterine growth restriction. ( Barry, JS; Brown, LD; Hay, WW; Limesand, SW; Rozance, PJ, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (55.56) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Kyllo, HM | 1 |
| Wang, D | 1 |
| Lorca, RA | 1 |
| Julian, CG | 1 |
| Moore, LG | 1 |
| Wilkening, RB | 1 |
| Rozance, PJ | 3 |
| Brown, LD | 2 |
| Wesolowski, SR | 1 |
| Limesand, SW | 2 |
| Barry, JS | 1 |
| Hay, WW | 2 |
| Charles-Edwards, GD | 1 |
| Jan, W | 1 |
| To, M | 1 |
| Maxwell, D | 1 |
| Keevil, SF | 1 |
| Robinson, R | 1 |
| Gilbert, JS | 1 |
| Bauer, AJ | 1 |
| Gingery, A | 1 |
| Banek, CT | 1 |
| Chasson, S | 1 |
| Junno, J | 1 |
| Bruun, E | 1 |
| Gutierrez, JH | 1 |
| Erkinaro, T | 3 |
| Haapsamo, M | 2 |
| Acharya, G | 3 |
| Räsänen, J | 3 |
| Kavasmaa, T | 2 |
| Päkkilä, M | 1 |
| Mäkikallio, K | 2 |
| Alahuhta, S | 1 |
| Smith, D | 1 |
| Mertens, L | 1 |
| Huhta, JC | 1 |
| Gagnon, R | 1 |
| Harding, R | 1 |
| Brace, RA | 1 |
9 other studies available for lactic acid and Placental Insufficiency
| Article | Year |
|---|---|
Adaptive responses in uteroplacental metabolism and fetoplacental nutrient shuttling and sensing during placental insufficiency.
Topics: Amino Acids; AMP-Activated Protein Kinases; Animals; Female; Fetal Growth Retardation; Fetus; Glucos | 2023 |
Glucose replacement to euglycemia causes hypoxia, acidosis, and decreased insulin secretion in fetal sheep with intrauterine growth restriction.
Topics: Acidosis; Amino Acids; Animals; Blood Glucose; Carbon Dioxide; Disease Models, Animal; Down-Regulati | 2009 |
Non-invasive detection and quantification of human foetal brain lactate in utero by magnetic resonance spectroscopy.
Topics: Adult; Biomarkers; Brain; Brain Chemistry; Female; Fetal Growth Retardation; Fetal Hypoxia; Fetus; H | 2010 |
Circulating and utero-placental adaptations to chronic placental ischemia in the rat.
Topics: Adaptation, Physiological; Animals; Female; Fetal Development; Fetal Growth Retardation; Fetus; Insu | 2012 |
Fetal sheep left ventricle is more sensitive than right ventricle to progressively worsening hypoxemia and acidemia.
Topics: Acidosis; Animals; Animals, Inbred Strains; Disease Models, Animal; Disease Progression; Female; Fin | 2013 |
Ephedrine and phenylephrine for the treatment of maternal hypotension in a chronic sheep model of increased placental vascular resistance.
Topics: Anesthesia, Epidural; Anesthesia, Obstetrical; Animals; Disease Models, Animal; Ephedrine; Female; H | 2006 |
Increased insulin sensitivity and maintenance of glucose utilization rates in fetal sheep with placental insufficiency and intrauterine growth restriction.
Topics: Animals; Blood Glucose; Cyclic AMP Response Element-Binding Protein; Female; Fetal Growth Retardatio | 2007 |
Metabolic acidosis decreases fetal myocardial isovolumic velocities in a chronic sheep model of increased placental vascular resistance.
Topics: Acidosis; Acute Disease; Animals; Blood Pressure; Cardiac Output; Central Venous Pressure; Chronic D | 2008 |
Amniotic fluid and fetal urinary responses to severe placental insufficiency in sheep.
Topics: Amniotic Fluid; Animals; Arteries; Body Water; Embryonic and Fetal Development; Female; Fetus; Gesta | 2002 |