lactic acid has been researched along with Periodontitis in 34 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Periodontitis: Inflammation and loss of connective tissues supporting or surrounding the teeth. This may involve any part of the PERIODONTIUM. Periodontitis is currently classified by disease progression (CHRONIC PERIODONTITIS; AGGRESSIVE PERIODONTITIS) instead of age of onset. (From 1999 International Workshop for a Classification of Periodontal Diseases and Conditions, American Academy of Periodontology)
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study aimed to develop pH-responsive polylactide-glycolic acid co-polymer and chitosan (PLGA/chitosan) nanosphere as an inflammation-responsive vehicle and evaluate the potential of the nanosphere encapsulating metronidazole, an antibiotic, and N-phenacylthiazolium bromide (PTB), a host modulator, for treating periodontitis." | 7.88 | Modulation of periodontitis progression using pH-responsive nanosphere encapsulating metronidazole or N-phenacylthialzolium bromide. ( Chang, PC; Feng, F; Lin, JH; Wang, CH; Yu, MC, 2018) |
| "Minocycline (MCL)-loaded in situ hydrogel was prepared composed of poly(lactide-coglycolide) (PLGA) and N-methylpyrrolidone (NMP) to improve the topical treatment effect of periodontitis." | 7.88 | Minocycline-loaded In situ Hydrogel for Periodontitis Treatment. ( Ma, J; Wang, F; Wang, X; Zhou, L; Zhu, X, 2018) |
| "To investigate the inhibitory effects of 25-hydroxyvitamin D3 (25(OH)D3)-loaded polylactic acid (PLA) microspheres on inflammatory response in diabetic periodontitis." | 7.80 | Attenuation of inflammatory response by 25- hydroxyvitamin D3-loaded polylactic acid microspheres in treatment of periodontitis in diabetic rats. ( Chen, XM; Li, B; Li, H; Li, W; Wang, Q; Xiao, Y, 2014) |
| "The purpose of this study is to formulate in situ implants containing doxycycline hydrochloride and/or secnidazole that could be used in the treatment of periodontitis by direct periodontal intrapocket administration." | 7.74 | Formulation and evaluation of PLA and PLGA in situ implants containing secnidazole and/or doxycycline for treatment of periodontitis. ( Abd El-Hady, SS; El-Nabarawi, MA; Gad, HA, 2008) |
| "The purpose of the study was to compare the effects of guided tissue regeneration (GTR) with expanded polytetrafluoroethylene (ePTFE) non-resorbable barriers and polylactic acid bioabsorbable barriers in humans with intrabony defects due to periodontitis." | 5.08 | Clinical comparison of bioabsorbable barriers with non-resorbable barriers in guided tissue regeneration in the treatment of human intrabony defects. ( Beck, FM; Claman, LJ; Solt, CW; Teparat, T, 1998) |
| "This study aimed to develop pH-responsive polylactide-glycolic acid co-polymer and chitosan (PLGA/chitosan) nanosphere as an inflammation-responsive vehicle and evaluate the potential of the nanosphere encapsulating metronidazole, an antibiotic, and N-phenacylthiazolium bromide (PTB), a host modulator, for treating periodontitis." | 3.88 | Modulation of periodontitis progression using pH-responsive nanosphere encapsulating metronidazole or N-phenacylthialzolium bromide. ( Chang, PC; Feng, F; Lin, JH; Wang, CH; Yu, MC, 2018) |
| "Minocycline (MCL)-loaded in situ hydrogel was prepared composed of poly(lactide-coglycolide) (PLGA) and N-methylpyrrolidone (NMP) to improve the topical treatment effect of periodontitis." | 3.88 | Minocycline-loaded In situ Hydrogel for Periodontitis Treatment. ( Ma, J; Wang, F; Wang, X; Zhou, L; Zhu, X, 2018) |
| "To investigate the inhibitory effects of 25-hydroxyvitamin D3 (25(OH)D3)-loaded polylactic acid (PLA) microspheres on inflammatory response in diabetic periodontitis." | 3.80 | Attenuation of inflammatory response by 25- hydroxyvitamin D3-loaded polylactic acid microspheres in treatment of periodontitis in diabetic rats. ( Chen, XM; Li, B; Li, H; Li, W; Wang, Q; Xiao, Y, 2014) |
| "The purpose of this study is to formulate in situ implants containing doxycycline hydrochloride and/or secnidazole that could be used in the treatment of periodontitis by direct periodontal intrapocket administration." | 3.74 | Formulation and evaluation of PLA and PLGA in situ implants containing secnidazole and/or doxycycline for treatment of periodontitis. ( Abd El-Hady, SS; El-Nabarawi, MA; Gad, HA, 2008) |
| "In 10 patients with treated chronic periodontitis, we randomly selected the 1st molars in the mandible with buccal degree II furcation involvement for either polylactic-citric-acid-ester (PLA) or glycolide-lactic-copolymer (PGL) GTR membrane therapy." | 2.70 | PMN responses following use of 2 biodegradable GTR membranes. ( Buchmann, R; Hasilik, A; Heinecke, A; Lange, DE, 2001) |
| "Periodontitis is the primary cause of tooth loss in adults and a very wide-spread disease." | 1.42 | In-situ forming composite implants for periodontitis treatment: How the formulation determines system performance. ( Delcourt, E; Do, MP; Mäder, K; Metz, H; Neut, C; Siepmann, F; Siepmann, J, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.94) | 18.7374 |
| 1990's | 5 (14.71) | 18.2507 |
| 2000's | 15 (44.12) | 29.6817 |
| 2010's | 13 (38.24) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Velusamy, SK | 1 |
| Sampathkumar, V | 1 |
| Ramasubbu, N | 1 |
| Paster, BJ | 1 |
| Fine, DH | 1 |
| Lin, JH | 1 |
| Feng, F | 1 |
| Yu, MC | 1 |
| Wang, CH | 1 |
| Chang, PC | 1 |
| Wang, X | 1 |
| Ma, J | 1 |
| Zhu, X | 1 |
| Wang, F | 1 |
| Zhou, L | 1 |
| Li, H | 2 |
| Wang, Q | 2 |
| Xiao, Y | 2 |
| Bao, C | 1 |
| Li, W | 2 |
| Glowacki, AJ | 1 |
| Yoshizawa, S | 1 |
| Jhunjhunwala, S | 1 |
| Vieira, AE | 1 |
| Garlet, GP | 1 |
| Sfeir, C | 1 |
| Little, SR | 1 |
| Li, B | 1 |
| Chen, XM | 1 |
| Do, MP | 2 |
| Neut, C | 2 |
| Metz, H | 2 |
| Delcourt, E | 2 |
| Mäder, K | 2 |
| Siepmann, J | 3 |
| Siepmann, F | 3 |
| Ranjbar-Mohammadi, M | 1 |
| Zamani, M | 1 |
| Prabhakaran, MP | 1 |
| Bahrami, SH | 1 |
| Ramakrishna, S | 1 |
| Freire, MO | 1 |
| Devaraj, A | 1 |
| Young, A | 1 |
| Navarro, JB | 1 |
| Downey, JS | 1 |
| Chen, C | 1 |
| Bakaletz, LO | 1 |
| Zadeh, HH | 1 |
| Goodman, SD | 1 |
| Fisher, PD | 1 |
| Clemens, J | 1 |
| Zach Hilt, J | 1 |
| Puleo, DA | 1 |
| de Freitas, LM | 1 |
| Calixto, GM | 1 |
| Chorilli, M | 1 |
| Giusti, JS | 1 |
| Bagnato, VS | 1 |
| Soukos, NS | 1 |
| Amiji, MM | 1 |
| Fontana, CR | 1 |
| Agossa, K | 1 |
| Lizambard, M | 1 |
| Rongthong, T | 1 |
| Delcourt-Debruyne, E | 1 |
| Gad, HA | 1 |
| El-Nabarawi, MA | 1 |
| Abd El-Hady, SS | 1 |
| Camargo, PM | 1 |
| Lekovic, V | 1 |
| Weinlaender, M | 1 |
| Vasilic, N | 1 |
| Madzarevic, M | 1 |
| Kenney, EB | 1 |
| Ehmke, B | 2 |
| Rüdiger, SG | 2 |
| Hommens, A | 2 |
| Karch, H | 2 |
| Flemmig, TF | 2 |
| Paquette, DW | 1 |
| Yue, IC | 1 |
| Poff, J | 1 |
| Cortés, ME | 1 |
| Sinisterra, RD | 1 |
| Faris, CB | 1 |
| Hildgen, P | 1 |
| Langer, R | 1 |
| Shastri, VP | 1 |
| Hou, LT | 1 |
| Yan, JJ | 1 |
| Tsai, AY | 1 |
| Lao, CS | 1 |
| Lin, SJ | 1 |
| Liu, CM | 1 |
| Jones, AA | 1 |
| Buser, D | 1 |
| Schenk, R | 1 |
| Wozney, J | 1 |
| Cochran, DL | 1 |
| Keles, GC | 2 |
| Cetinkaya, BO | 2 |
| Albayrak, D | 1 |
| Koprulu, H | 2 |
| Acikgoz, G | 3 |
| Sakallioglu, U | 1 |
| Yavuz, U | 1 |
| Lütfioglu, M | 1 |
| Keskiner, I | 1 |
| Ayas, B | 1 |
| Isildak, I | 1 |
| Diraman, E | 1 |
| Lapilin, AV | 1 |
| Raĭgorodskiĭ, IuM | 1 |
| Bulkina, NV | 1 |
| Bashkova, LV | 1 |
| Osipova, IuL | 1 |
| Erokina, NL | 1 |
| Bisultanov, KhU | 1 |
| Maze, GI | 1 |
| Reinhardt, RA | 1 |
| Agarwal, RK | 1 |
| Dyer, JK | 1 |
| Robinson, DH | 1 |
| DuBois, LM | 1 |
| Tussing, GJ | 1 |
| Maze, CR | 1 |
| Kinoshita, A | 1 |
| Oda, S | 1 |
| Takahashi, K | 1 |
| Yokota, S | 1 |
| Ishikawa, I | 1 |
| Niederman, R | 1 |
| Zhang, J | 1 |
| Kashket, S | 1 |
| Polson, AM | 1 |
| Southard, GL | 1 |
| Dunn, RL | 1 |
| Polson, AP | 1 |
| Yewey, GL | 1 |
| Swanbom, DD | 1 |
| Fulfs, JC | 1 |
| Rodgers, PW | 1 |
| Teparat, T | 1 |
| Solt, CW | 1 |
| Claman, LJ | 1 |
| Beck, FM | 1 |
| Bromberg, LE | 2 |
| Braman, VM | 1 |
| Rothstein, DM | 1 |
| Spacciapoli, P | 1 |
| O'Connor, SM | 1 |
| Nelson, EJ | 1 |
| Buxton, DK | 2 |
| Tonetti, MS | 1 |
| Friden, PM | 2 |
| Buchmann, R | 1 |
| Hasilik, A | 1 |
| Heinecke, A | 1 |
| Lange, DE | 1 |
| Sornin, C | 1 |
| Bousquet, C | 1 |
| David, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of Efficacy of Autologous Platelet - Rich Plasma Combined With Demineralized Freeze - Dried Bone Allograft Versus Demineralized Freeze - Dried Bone Allograft: A Randomized Clinical Trial in Central India[NCT05886699] | 13 participants (Actual) | Interventional | 2012-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for lactic acid and Periodontitis
| Article | Year |
|---|---|
Short-chain carboxylic-acid-stimulated, PMN-mediated gingival inflammation.
Topics: Bacteria, Anaerobic; Butyrates; Butyric Acid; Cytokines; Dental Caries; Endothelium; Epithelium; Fib | 1997 |
10 trials available for lactic acid and Periodontitis
| Article | Year |
|---|---|
Polymeric Nanoparticle-Based Photodynamic Therapy for Chronic Periodontitis in Vivo.
Topics: Adult; Aged; Biofilms; Female; Humans; Lactic Acid; Male; Methylene Blue; Middle Aged; Nanoparticles | 2016 |
Platelet-rich plasma and bovine porous bone mineral combined with guided tissue regeneration in the treatment of intrabony defects in humans.
Topics: Absorbable Implants; Adult; Alveolar Bone Loss; Alveolar Process; Animals; Blood Platelets; Bone Mat | 2002 |
Minocycline microspheres: a complementary medical-mechanical model for the treatment of chronic periodontitis.
Topics: Analysis of Variance; Anti-Bacterial Agents; Chronic Disease; Delayed-Action Preparations; Dental Sc | 2002 |
Polymer-assisted regeneration therapy with Atrisorb barriers in human periodontal intrabony defects.
Topics: Absorbable Implants; Adult; Alveolar Bone Loss; Anti-Bacterial Agents; Biocompatible Materials; Bone | 2004 |
Comparison of platelet pellet and bioactive glass in periodontal regenerative therapy.
Topics: Absorbable Implants; Adult; Alveolar Bone Loss; Biocompatible Materials; Bone Substitutes; Ceramics; | 2006 |
Clinical outcomes of guided tissue regeneration with Atrisorb membrane in the treatment of intrabony defects: a 3-year follow-up study.
Topics: Absorbable Implants; Adult; Alveolar Bone Loss; Analysis of Variance; Female; Follow-Up Studies; Gui | 2007 |
Levels of gingival tissue platelet activating factor after conventional and regenerative periodontal surgery.
Topics: Adult; Alveolar Bone Loss; Capillaries; Chromatography, High Pressure Liquid; Female; Follow-Up Stud | 2007 |
Response to intracrevicular controlled delivery of 25% tetracycline from poly(lactide/glycolide) film strips in SPT patients.
Topics: Adult; Aged; Anti-Bacterial Agents; Bacteria; Biocompatible Materials; Colony Count, Microbial; Dela | 1995 |
Clinical comparison of bioabsorbable barriers with non-resorbable barriers in guided tissue regeneration in the treatment of human intrabony defects.
Topics: Absorption; Adult; Aged; Alveolar Bone Loss; Dental Plaque Index; Female; Follow-Up Studies; Gingiva | 1998 |
PMN responses following use of 2 biodegradable GTR membranes.
Topics: Absorbable Implants; beta-N-Acetylhexosaminidases; Chronic Disease; Dental Plaque Index; Female; Fol | 2001 |
23 other studies available for lactic acid and Periodontitis
| Article | Year |
|---|---|
Topics: Aggregatibacter actinomycetemcomitans; Animals; Bacterial Adhesion; Biofilms; Durapatite; Exotoxins; | 2019 |
Modulation of periodontitis progression using pH-responsive nanosphere encapsulating metronidazole or N-phenacylthialzolium bromide.
Topics: Animals; Anti-Infective Agents; Chitosan; Disease Models, Animal; Disease Progression; Lactic Acid; | 2018 |
Minocycline-loaded In situ Hydrogel for Periodontitis Treatment.
Topics: Animals; Anti-Bacterial Agents; Dinoprostone; Drug Carriers; Drug Liberation; Gingiva; Hydrogels; La | 2018 |
25-Hydroxyvitamin D(3)-loaded PLA microspheres: in vitro characterization and application in diabetic periodontitis models.
Topics: Alveolar Bone Loss; Animals; Calcifediol; Cell Survival; Cells, Cultured; Chemistry, Pharmaceutical; | 2013 |
Prevention of inflammation-mediated bone loss in murine and canine periodontal disease via recruitment of regulatory lymphocytes.
Topics: Aggregatibacter actinomycetemcomitans; Alveolar Bone Loss; Animals; Chemokine CCL22; Delayed-Action | 2013 |
Attenuation of inflammatory response by 25- hydroxyvitamin D3-loaded polylactic acid microspheres in treatment of periodontitis in diabetic rats.
Topics: Administration, Topical; Aggregatibacter actinomycetemcomitans; Alveolar Bone Loss; Animals; Anti-In | 2014 |
In-situ forming composite implants for periodontitis treatment: How the formulation determines system performance.
Topics: Adhesives; Adult; Aged; Anti-Bacterial Agents; Bacteria; Chemistry, Pharmaceutical; Doxycycline; Dru | 2015 |
Mechanistic analysis of PLGA/HPMC-based in-situ forming implants for periodontitis treatment.
Topics: Adhesiveness; Anti-Bacterial Agents; Drug Compounding; Drug Implants; Drug Liberation; Fusobacterium | 2015 |
Electrospinning of PLGA/gum tragacanth nanofibers containing tetracycline hydrochloride for periodontal regeneration.
Topics: Anti-Bacterial Agents; Bacteria; Cell Proliferation; Cells, Cultured; Drug Carriers; Electrochemical | 2016 |
A bacterial-biofilm-induced oral osteolytic infection can be successfully treated by immuno-targeting an extracellular nucleoid-associated protein.
Topics: Animals; Bacteria; Biofilms; Dental Implants; Disease Models, Animal; DNA-Binding Proteins; Escheric | 2017 |
Multifunctional poly(β-amino ester) hydrogel microparticles in periodontal in situ forming drug delivery systems.
Topics: Biocompatible Materials; Biomechanical Phenomena; Doxycycline; Drug Delivery Systems; Drug Implants; | 2016 |
Physical key properties of antibiotic-free, PLGA/HPMC-based in-situ forming implants for local periodontitis treatment.
Topics: Adhesiveness; Anti-Infective Agents, Local; Chlorhexidine; Drug Implants; Humans; Hypromellose Deriv | 2017 |
Formulation and evaluation of PLA and PLGA in situ implants containing secnidazole and/or doxycycline for treatment of periodontitis.
Topics: Absorbable Implants; Chemistry, Pharmaceutical; Doxycycline; Drug Carriers; Drug Combinations; Drug | 2008 |
Guided tissue regeneration using a polylactic acid barrier.
Topics: Adolescent; Adult; Aged; Alveolar Bone Loss; Alveolar Process; Bacteroidaceae Infections; Chronic Di | 2003 |
Guided tissue regeneration using a polylactic acid barrier. Part I: Environmental effects on bacterial colonization.
Topics: Absorbable Implants; Adolescent; Adult; Aged; Aggregatibacter actinomycetemcomitans; Alveolar Bone L | 2003 |
A novel polymeric chlorhexidine delivery device for the treatment of periodontal disease.
Topics: Anti-Infective Agents, Local; Chlorhexidine; Cyclodextrins; Delayed-Action Preparations; Drug Delive | 2004 |
The effect of rhBMP-2 around endosseous implants with and without membranes in the canine model.
Topics: Absorbable Implants; Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Collagen; D | 2006 |
[Biochemical markers of chronic generalized parodontitis treatment efficacy with the use of device AMO-ATOC-[CURVED BACKWARDS E SYMBOL]].
Topics: Adolescent; Adult; Biomarkers; Calcium; Equipment Design; Female; Glucose; Humans; Hydrogen-Ion Conc | 2007 |
Periodontal regeneration by application of recombinant human bone morphogenetic protein-2 to horizontal circumferential defects created by experimental periodontitis in beagle dogs.
Topics: Alveolar Bone Loss; Animals; Biocompatible Materials; Bone Morphogenetic Protein 2; Bone Morphogenet | 1997 |
Periodontal healing after guided tissue regeneration with Atrisorb barriers in beagle dogs.
Topics: Alveolar Bone Loss; Animals; Dogs; Female; Follow-Up Studies; Furcation Defects; Guided Tissue Regen | 1995 |
Sustained release of silver from periodontal wafers for treatment of periodontitis.
Topics: Administration, Buccal; Anti-Infective Agents; Delayed-Action Preparations; Drug Carriers; Drug Deli | 2000 |
Novel periodontal drug delivery system for treatment of periodontitis.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Cellulose; Cross-Linking Reagents; Drug Delivery Syste | 2001 |
[Lactic acid formation in the oral cavity].
Topics: Electrophoresis; Humans; Isoenzymes; L-Lactate Dehydrogenase; Lactates; Lactic Acid; Lip; Periodonti | 1986 |