Page last updated: 2024-10-17

lactic acid and Panic Attacks

lactic acid has been researched along with Panic Attacks in 60 studies

Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.

Research Excerpts

ExcerptRelevanceReference
"Panic patients consistently show exaggerated lactic acid response to alkalosis, whether produced by hyperventilation or by sodium lactate infusion."8.81The lactic acid response to alkalosis in panic disorder : an integrative review. ( Maddock, RJ, 2001)
"These results suggest that the compensatory metabolic response to acute respiratory alkalosis is exaggerated by increased lactic acid production in panic disorder patients."7.75Exaggerated compensatory response to acute respiratory alkalosis in panic disorder is induced by increased lactic acid production. ( Aizawa, M; Fujii, M; Isaka, Y; Takahashi, A; Ueda, Y, 2009)
"This study investigates whether naloxone, an opioid receptor antagonist, could render normal controls, normally nonresponsive to panic inducing stimuli, sensitive to the physiological and behavioral effects of sodium lactate, a robust panicogen in panic disorder patients."7.74Physiological and behavioral effects of naloxone and lactate in normal volunteers with relevance to the pathophysiology of panic disorder. ( Goetz, RR; Klein, DF; Sinha, SS, 2007)
"The response to treatment with imipramine or clonazepam was evaluated in patients with panic disorder."7.68[Treatment of patients with panic disorder and an elevated urinary excretion of MHPG using imipramine or clonazepam]. ( Carreira, I; Casique, M; Lima, L; Morales, M; Silva, C, 1992)
"To assess the role of noradrenergic stimulation during lactate-induced panic, ten patients with panic disorder who panicked during a standard sodium-lactate infusion underwent a repeat infusion following intravenous clonidine pretreatment."7.68Noradrenergic function in panic disorder. Effects of intravenous clonidine pretreatment on lactate induced panic. ( Campeas, RB; Coplan, JD; Davies, SO; Dillon, DJ; Fyer, AJ; Gorman, JM; Klein, DF; Liebowitz, MR; Martinez, J, 1992)
"Six subjects with panic disorder underwent sodium lactate infusions in conjunction with magnetic resonance spectroscopic imaging (MRSI) at study entrance when actively symptomatic and after clinical improvement while under treatment with gabapentin."5.09Brain metabolic changes during lactate-induced panic: effects of gabapentin treatment. ( Dager, SR; Friedman, SD; Layton, ME, 2001)
"Nine patients with panic disorders, previously shown to panic in response to intravenously administered lactate, and 10 control subjects underwent the Read rebreathing test by a 5-min inhalation of a 7% CO2/93% O2 mixture before and after 1 month of fluoxetine treatment."5.08Antipanic effect of fluoxetine measured by CO2 challenge test. ( Bocola, V; Fabbrini, G; Martucci, N; Paladini, C; Sollecito, A; Trecco, MD, 1998)
"To examine the effect of treatment on lactate-induced anxiety in a controlled study, we infused 44 panic disorder patients with lactate and placebo before and after eight weeks of double-blind treatment with imipramine, diazepam, or placebo."5.07Lactate-induced anxiety after imipramine and diazepam treatment. ( Balon, R; Berchou, R; Lycaki, H; Pohl, R, 1994)
"Panic patients consistently show exaggerated lactic acid response to alkalosis, whether produced by hyperventilation or by sodium lactate infusion."4.81The lactic acid response to alkalosis in panic disorder : an integrative review. ( Maddock, RJ, 2001)
"Various provocative agents, including sodium lactate, carbon dioxide (CO2), caffeine, yohimbine and cholecystokinin (CCK), have been utilized as panicogenics in studies on healthy volunteers as well as in panic disorder patients."4.79[From inducers of panic attack to neurobiology of panic disorder]. ( Bourin, M, 1996)
"These results suggest that the compensatory metabolic response to acute respiratory alkalosis is exaggerated by increased lactic acid production in panic disorder patients."3.75Exaggerated compensatory response to acute respiratory alkalosis in panic disorder is induced by increased lactic acid production. ( Aizawa, M; Fujii, M; Isaka, Y; Takahashi, A; Ueda, Y, 2009)
"The purpose of this study was to investigate the brain gamma-aminobutyric acid (GABA) concentration and its relationship with clinical variables in patients with panic disorder (PD)."3.74Decreased GABA levels in anterior cingulate and basal ganglia in medicated subjects with panic disorder: a proton magnetic resonance spectroscopy (1H-MRS) study. ( Ham, BJ; Kim, DJ; Kim, JE; Kim, JH; Kim, N; Kim, SJ; Lee, JY; Lyoo, IK; Sung, Y; Yoon, SJ, 2007)
"This study investigates whether naloxone, an opioid receptor antagonist, could render normal controls, normally nonresponsive to panic inducing stimuli, sensitive to the physiological and behavioral effects of sodium lactate, a robust panicogen in panic disorder patients."3.74Physiological and behavioral effects of naloxone and lactate in normal volunteers with relevance to the pathophysiology of panic disorder. ( Goetz, RR; Klein, DF; Sinha, SS, 2007)
"The response to treatment with imipramine or clonazepam was evaluated in patients with panic disorder."3.68[Treatment of patients with panic disorder and an elevated urinary excretion of MHPG using imipramine or clonazepam]. ( Carreira, I; Casique, M; Lima, L; Morales, M; Silva, C, 1992)
"The present study assessed the relation of cortisol response to anxiogenic reactivity during intravenous lactate infusion and oral fenfluramine in 12 panic disorder (PD) patients who responded positively to both challenges and in eight non-reactive control subjects."3.68Cortisol response during different anxiogenic challenges in panic disorder patients. ( Targum, SD, 1992)
"To assess the role of noradrenergic stimulation during lactate-induced panic, ten patients with panic disorder who panicked during a standard sodium-lactate infusion underwent a repeat infusion following intravenous clonidine pretreatment."3.68Noradrenergic function in panic disorder. Effects of intravenous clonidine pretreatment on lactate induced panic. ( Campeas, RB; Coplan, JD; Davies, SO; Dillon, DJ; Fyer, AJ; Gorman, JM; Klein, DF; Liebowitz, MR; Martinez, J, 1992)
"The diazepam pretreatment condition was associated with a significantly increased infusion duration and a significant attenuation of rate of API symptom increase in response to lactate."2.68Effects of intravenous diazepam pretreatment on lactate-induced panic. ( Campeas, RB; Coplan, JD; Davies, SO; Dillon, DJ; Fyer, AJ; Gorman, JM; Klein, DF; Liebowitz, MR; Martinez, J, 1995)
"Panic disorder is a common and disabling illness for which treatments are too frequently ineffective."2.47Neurobiology of panic and pH chemosensation in the brain. ( Wemmie, JA, 2011)
"Acute hyperventilation is neither necessary nor sufficient for panic to occur."2.38Carbon dioxide hypersensitivity, hyperventilation, and panic disorder. ( Gorman, JM; Klein, DF; Papp, LA, 1993)

Research

Studies (60)

TimeframeStudies, this research(%)All Research%
pre-19901 (1.67)18.7374
1990's44 (73.33)18.2507
2000's12 (20.00)29.6817
2010's3 (5.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
de Souza Armini, R1
Bernabé, CS1
Rosa, CA1
Siller, CA1
Schimitel, FG1
Tufik, S1
Klein, DF11
Schenberg, LC1
Ueda, Y1
Aizawa, M1
Takahashi, A1
Fujii, M1
Isaka, Y1
Kukumberg, P1
Valkovic, P1
Blazicek, P1
Guth, A1
Martinkova, J1
Provaznik, V1
Jagla, F1
Preter, M1
Lee, SH1
Petkova, E1
Vannucci, M1
Kim, S1
Wemmie, JA1
Shekhar, A2
Johnson, PL1
Sajdyk, TJ1
Fitz, SD1
Keim, SR2
Kelley, PE1
Gehlert, DR1
DiMicco, JA1
Ham, BJ1
Sung, Y1
Kim, N1
Kim, SJ1
Kim, JE1
Kim, DJ1
Lee, JY1
Kim, JH1
Yoon, SJ1
Lyoo, IK1
Sinha, SS1
Goetz, RR4
Graeff, FG1
Maddock, RJ3
Buonocore, MH1
Copeland, LE1
Richards, AL1
Kellner, M2
Herzog, L1
Yassouridis, A2
Holsboer, F1
Wiedemann, K2
Robinson, D1
Casso, DE1
Omar, SJ1
Tinklenberg, JR1
George, DT2
Lindquist, T2
Nutt, DJ2
Ragan, PW2
Alim, T2
McFarlane, V1
Leviss, J1
Eckardt, MJ2
Linnoila, M2
Reschke, AH1
Mannuzza, S1
Chapman, TF1
Lipsitz, JD1
Liebowitz, MR4
Gorman, JM9
Fyer, AJ4
Koenigsberg, HW1
Pollak, CP1
Fine, J1
Kakuma, T1
Yeragani, VK2
Srinivasan, K1
Balon, R3
Ramesh, C1
Berchou, R2
Dager, SR5
Marro, KI1
Richards, TL2
Metzger, GD2
McArthur, P1
Kellner, CH1
Pritchett, JT1
Beale, MD1
Burns, CM1
Bernstein, HJ1
Ruby, RN1
Lambiotte, C1
Moigne, E1
Pichene, C1
Hennequin, L1
Hoffman, M1
Lambert, H1
Larcan, A1
Kenny, MA1
Artru, AA1
Bowden, DM1
Rainey, JM1
Peskind, ER4
Radant, A1
Dobie, DJ1
Hughes, J2
Wilkinson, CW2
Sikkema, C1
Veith, RC2
Dorsa, DM1
Raskind, MA4
Papp, LA2
Pohl, R2
Merlos, B1
Sherwood, P1
Sandberg, D1
Endicott, J1
Harrison, W1
Nee, J1
Gorman, J1
Gully, R1
Kahn, J1
De Cristofaro, MT1
Sessarego, A1
Pupi, A1
Biondi, F1
Faravelli, C1
Keck, PE1
Taylor, VE1
Tugrul, KC1
McElroy, SL1
Bennett, JA1
Coplan, JD3
Martinez, J3
Dillon, DJ2
Campeas, RB2
Davies, SO2
Cowley, DS2
Adams, JB1
Pyke, RE1
Cook, J1
Zaccharias, P1
Wingerson, D1
Roy-Byrne, PP1
van Megen, HJ1
Westenberg, HG1
den Boer, JA1
Simon, JR1
McBride, WJ1
Bourin, M1
Brown, TM1
Gurguis, GN1
Lycaki, H1
Seier, FE1
Heese, R1
Strian, F1
Broocks, A1
Meyer, TF1
Bandelow, B1
George, A1
Bartmann, U1
Rüther, E1
Hillmer-Vogel, U1
Richards, T1
Strauss, W1
Artru, A1
Bocola, V1
Trecco, MD1
Fabbrini, G1
Paladini, C1
Sollecito, A1
Martucci, N1
Jensen, CF3
Keller, TW1
McFall, ME1
Pascualy, M1
Tsuang, D1
Cowley, D1
Martin, DC1
Griez, E1
Schruers, K1
Bell, CJ1
Malizia, AL1
Friedman, SD2
Petropoulos, H1
Posse, S1
Auriacombe, M1
Rénéric, JP1
Usandizaga, D1
Gomez, F1
Combourieu, I1
Tignol, J1
Layton, ME1
Davies, DR1
Davies, DD1
Lima, L1
Carreira, I1
Morales, M1
Silva, C1
Casique, M1
Stein, JM1
Cohen, S1
Simon, J1
Ross, D1
Targum, SD1
Sharma, T1
Rosenblum, LA1
Friedman, S1
Bassoff, TB1
Barbour, RL1
Nutt, D1
Lawson, C1
Fontaine, S2
Ontiveros, A2
Fontaine, R2
Elie, R2
Carter, CS1
Gietzen, DW1
Roy-Byrne, P1
Breton, G1
Déry, R1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Role of Orexin in Human Panic Disorder[NCT02593682]Phase 43 participants (Actual)Interventional2016-05-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

9 reviews available for lactic acid and Panic Attacks

ArticleYear
Neurobiology of panic and pH chemosensation in the brain.
    Dialogues in clinical neuroscience, 2011, Volume: 13, Issue:4

    Topics: Animals; Brain Chemistry; Carbon Dioxide; Chemoreceptor Cells; Humans; Hydrogen-Ion Concentration; L

2011
[Anxiety, panic and the hypothalamic-pituitary-adrenal axis].
    Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999), 2007, Volume: 29 Suppl 1

    Topics: Adrenocorticotropic Hormone; Animals; Carbon Dioxide; Disease Models, Animal; Humans; Hypothalamo-Hy

2007
[Absence of mitral valve prolapse during panic attacks induced by sodium lactate].
    Presse medicale (Paris, France : 1983), 1993, May-22, Volume: 22, Issue:18

    Topics: Adolescent; Adult; Double-Blind Method; Echocardiography, Doppler; Hemodynamics; Humans; Lactates; L

1993
Carbon dioxide hypersensitivity, hyperventilation, and panic disorder.
    The American journal of psychiatry, 1993, Volume: 150, Issue:8

    Topics: Alkalosis, Respiratory; Carbon Dioxide; Cognitive Behavioral Therapy; Humans; Hyperventilation; Lact

1993
[From inducers of panic attack to neurobiology of panic disorder].
    L'Encephale, 1996, Volume: 22 Spec No 5

    Topics: Arousal; Brain; Caffeine; Carbon Dioxide; Cholecystokinin; Humans; Lactic Acid; Neurotransmitter Age

1996
Experimental pathophysiology of panic.
    Journal of psychosomatic research, 1998, Volume: 45, Issue:6

    Topics: Carbon Dioxide; Female; Genetic Predisposition to Disease; Humans; Lactic Acid; Male; Models, Biolog

1998
The neurobiology of social phobia.
    European archives of psychiatry and clinical neuroscience, 1999, Volume: 249 Suppl 1

    Topics: Brain; Caffeine; Carbon Dioxide; Cholecystokinin; Epinephrine; Female; Flumazenil; Human Growth Horm

1999
The lactic acid response to alkalosis in panic disorder : an integrative review.
    The Journal of neuropsychiatry and clinical neurosciences, 2001,Winter, Volume: 13, Issue:1

    Topics: Alkalosis; Arousal; Brain; Humans; Lactic Acid; Panic Disorder

2001
Panic attacks. A neurochemical overview of models and mechanisms.
    The British journal of psychiatry : the journal of mental science, 1992, Volume: 160

    Topics: Bicarbonates; Caffeine; Female; Humans; Hypercapnia; Hyperventilation; Lactates; Lactic Acid; Male;

1992

Trials

21 trials available for lactic acid and Panic Attacks

ArticleYear
Controlled cross-over study in normal subjects of naloxone-preceding-lactate infusions; respiratory and subjective responses: relationship to endogenous opioid system, suffocation false alarm theory and childhood parental loss.
    Psychological medicine, 2011, Volume: 41, Issue:2

    Topics: Adolescent; Adult; Anxiety, Separation; Cross-Over Studies; Female; Humans; Lactic Acid; Male; Middl

2011
Possible role of atrial natriuretic hormone in pituitary-adrenocortical unresponsiveness in lactate-induced panic.
    The American journal of psychiatry, 1995, Volume: 152, Issue:9

    Topics: Adrenocorticotropic Hormone; Adult; Atrial Natriuretic Factor; Double-Blind Method; Female; Heart Ra

1995
Effect of chloride or glucose on the incidence of lactate-induced panic attacks.
    The American journal of psychiatry, 1995, Volume: 152, Issue:5

    Topics: Blood Glucose; Blood Pressure; Double-Blind Method; Female; Glucose; Heart Rate; Humans; Incidence;

1995
Lactate sensitivity and cardiac cholinergic function in panic disorder.
    The American journal of psychiatry, 1994, Volume: 151, Issue:8

    Topics: Adult; Electrocardiography; Female; Heart; Heart Rate; Humans; Infusions, Intravenous; Lactates; Lac

1994
[Absence of mitral valve prolapse during panic attacks induced by sodium lactate].
    Presse medicale (Paris, France : 1983), 1993, May-22, Volume: 22, Issue:18

    Topics: Adolescent; Adult; Double-Blind Method; Echocardiography, Doppler; Hemodynamics; Humans; Lactates; L

1993
Changes in appetite and weight during the pharmacological treatment of patients with panic disorder.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1993, Volume: 38, Issue:1

    Topics: Adult; Agoraphobia; Appetite; Body Weight; Diazepam; Dietary Carbohydrates; Double-Blind Method; Fem

1993
Sodium lactate infusion in late luteal phase dysphoric disorder.
    Psychiatry research, 1993, Volume: 46, Issue:1

    Topics: Adult; Arousal; Blood Pressure; Female; Heart Rate; Humans; Lactates; Lactic Acid; Luteal Phase; Pan

1993
Effects of intravenous diazepam pretreatment on lactate-induced panic.
    Psychiatry research, 1995, Sep-29, Volume: 58, Issue:2

    Topics: Adult; Agoraphobia; Anti-Anxiety Agents; Arousal; Blood Pressure; Diazepam; Fear; Female; Heart Rate

1995
Symptoms essential to the experience of sodium lactate-induced panic.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1996, Volume: 14, Issue:5

    Topics: Dose-Response Relationship, Drug; Female; Humans; Infusions, Intravenous; Lactates; Lactic Acid; Log

1996
Effect of CI-988, a cholecystokinin-B receptor antagonist, on lactate-induced panic.
    Biological psychiatry, 1996, Sep-15, Volume: 40, Issue:6

    Topics: Adult; Anti-Anxiety Agents; Anxiety; Double-Blind Method; Female; Heart Rate; Humans; Indoles; Lacti

1996
Effect of the cholecystokinin-B receptor antagonist L-365,260 on lactate-induced panic attacks in panic disorder patients.
    Biological psychiatry, 1996, Oct-15, Volume: 40, Issue:8

    Topics: Adult; Agoraphobia; Arousal; Benzodiazepinones; Double-Blind Method; Female; Humans; Lactic Acid; Ma

1996
Decline in serum lactate levels over time.
    Anxiety, 1994, Volume: 1, Issue:1

    Topics: Administration, Oral; Adult; Antidepressive Agents, Tricyclic; Circadian Rhythm; Cross-Over Studies;

1994
Lactate-induced anxiety after imipramine and diazepam treatment.
    Anxiety, 1994, Volume: 1, Issue:2

    Topics: Adolescent; Adult; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Anxiety Disorders; Arousal

1994
Autonomic reactivity and hormonal secretion in lactate-induced panic attacks.
    The American journal of physiology, 1997, Volume: 272, Issue:6 Pt 2

    Topics: Adult; Atrial Natriuretic Factor; Autonomic Nervous System; Blood Pressure; Double-Blind Method; End

1997
Effect of alcoholism on the incidence of lactate-induced panic attacks.
    Biological psychiatry, 1997, Dec-01, Volume: 42, Issue:11

    Topics: Adult; Alcoholism; Female; Hemodynamics; Hormones; Humans; Lactic Acid; Male; Panic Disorder; Psychi

1997
Exercise avoidance and impaired endurance capacity in patients with panic disorder.
    Neuropsychobiology, 1997, Volume: 36, Issue:4

    Topics: Adolescent; Adult; Exercise; Exercise Test; Female; Humans; Kinetics; Lactic Acid; Male; Middle Aged

1997
Antipanic effect of fluoxetine measured by CO2 challenge test.
    Biological psychiatry, 1998, Apr-15, Volume: 43, Issue:8

    Topics: Adult; Antidepressive Agents, Second-Generation; Carbon Dioxide; Female; Fluoxetine; Humans; Lactic

1998
Comparison of sodium lactate-induced panic symptoms between panic disorder and posttraumatic stress disorder.
    Depression and anxiety, 1998, Volume: 7, Issue:3

    Topics: Adult; Analysis of Variance; Anxiety; Diagnosis, Differential; Female; Humans; Infusions, Intravenou

1998
Sodium lactate and hypertonic sodium chloride induce equivalent panic incidence, panic symptoms, and hypernatremia in panic disorder.
    Biological psychiatry, 1998, Nov-15, Volume: 44, Issue:10

    Topics: Acidosis; Adrenocorticotropic Hormone; Adult; Alkalosis; Arginine Vasopressin; Double-Blind Method;

1998
Brain metabolic changes during lactate-induced panic: effects of gabapentin treatment.
    Depression and anxiety, 2001, Volume: 14, Issue:4

    Topics: Acetates; Adult; Amines; Arousal; Aspartic Acid; Brain; Cyclohexanecarboxylic Acids; Double-Blind Me

2001
Hypertonic saline infusion induces panic in patients with panic disorder.
    Biological psychiatry, 1991, Sep-15, Volume: 30, Issue:6

    Topics: Adult; Double-Blind Method; Humans; Lactates; Lactic Acid; Male; Middle Aged; Panic; Panic Disorder;

1991

Other Studies

31 other studies available for lactic acid and Panic Attacks

ArticleYear
In a rat model of panic, corticotropin responses to dorsal periaqueductal gray stimulation depend on physical exertion.
    Psychoneuroendocrinology, 2015, Volume: 53

    Topics: Adrenocorticotropic Hormone; Animals; Behavior, Animal; Corticosterone; Disease Models, Animal; Elec

2015
Exaggerated compensatory response to acute respiratory alkalosis in panic disorder is induced by increased lactic acid production.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2009, Volume: 24, Issue:3

    Topics: Acid-Base Equilibrium; Adolescent; Adult; Alkalosis, Respiratory; Blood Gas Analysis; Cohort Studies

2009
Sweat: a potential marker of clinical activity in panic disorder.
    Neuro endocrinology letters, 2009, Volume: 30, Issue:3

    Topics: Adult; Analysis of Variance; Biomarkers; Chlorine; Creatinine; Female; Glucose; Humans; Lactic Acid;

2009
Angiotensin-II is a putative neurotransmitter in lactate-induced panic-like responses in rats with disruption of GABAergic inhibition in the dorsomedial hypothalamus.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006, Sep-06, Volume: 26, Issue:36

    Topics: Angiotensin II; Animals; Behavior, Animal; gamma-Aminobutyric Acid; Hypothalamus; Lactic Acid; Male;

2006
Decreased GABA levels in anterior cingulate and basal ganglia in medicated subjects with panic disorder: a proton magnetic resonance spectroscopy (1H-MRS) study.
    Progress in neuro-psychopharmacology & biological psychiatry, 2007, Mar-30, Volume: 31, Issue:2

    Topics: Adult; Basal Ganglia; Case-Control Studies; Choline; Female; gamma-Aminobutyric Acid; Gyrus Cinguli;

2007
Physiological and behavioral effects of naloxone and lactate in normal volunteers with relevance to the pathophysiology of panic disorder.
    Psychiatry research, 2007, Jan-15, Volume: 149, Issue:1-3

    Topics: Acute Disease; Adult; Female; Humans; Injections, Intravenous; Lactic Acid; Male; Middle Aged; Nalox

2007
Elevated brain lactate responses to neural activation in panic disorder: a dynamic 1H-MRS study.
    Molecular psychiatry, 2009, Volume: 14, Issue:5

    Topics: Adult; Aspartic Acid; Brain; Brain Mapping; Case-Control Studies; Female; Humans; Lactic Acid; Magne

2009
Possible oral lactate exacerbation of panic disorder.
    The Annals of pharmacotherapy, 1995, Volume: 29, Issue:5

    Topics: Administration, Oral; Adult; Drug Synergism; Female; Humans; Lactates; Lactic Acid; Lorazepam; Panic

1995
Sodium lactate response and familial risk for panic disorder.
    The American journal of psychiatry, 1995, Volume: 152, Issue:2

    Topics: Biomarkers; Family; Female; Humans; Lactates; Lactic Acid; Male; Panic Disorder; Risk Factors

1995
Cardiac and respiratory activity in panic disorder: effects of sleep and sleep lactate infusions.
    The American journal of psychiatry, 1994, Volume: 151, Issue:8

    Topics: Adolescent; Adult; Animals; Carbon Dioxide; Female; Glucose; Heart Rate; Humans; Infusion Pumps; Inf

1994
Preliminary application of magnetic resonance spectroscopy to investigate lactate-induced panic.
    The American journal of psychiatry, 1994, Volume: 151, Issue:1

    Topics: Adult; Brain Chemistry; Female; Humans; Infusions, Intravenous; Lactates; Lactic Acid; Magnetic Reso

1994
Panic induced by lactate infusion during electroconvulsive therapy?
    The Journal of nervous and mental disease, 1994, Volume: 182, Issue:1

    Topics: Depressive Disorder; Electroconvulsive Therapy; Humans; Infusions, Intravenous; Isotonic Solutions;

1994
Effects of sodium lactate infusion on cisternal lactate and carbon dioxide levels.
    The American journal of psychiatry, 1993, Volume: 150, Issue:10

    Topics: Animals; Carbon Dioxide; Cerebrospinal Fluid; Cisterna Magna; Disease Models, Animal; Haplorhini; Hu

1993
Hypertonic saline infusion increases plasma norepinephrine concentrations in normal men.
    Psychoneuroendocrinology, 1993, Volume: 18, Issue:2

    Topics: Adrenocorticotropic Hormone; Adult; Arginine Vasopressin; Blood Pressure; Epinephrine; Humans; Hydro

1993
Panic attacks during placebo procedures in the laboratory. Physiology and symptomatology.
    Archives of general psychiatry, 1993, Volume: 50, Issue:4

    Topics: Adult; Alkalosis; Carbon Dioxide; Diagnosis, Differential; Female; Heart Rate; Humans; Lactates; Lac

1993
Brain perfusion abnormalities in drug-naive, lactate-sensitive panic patients: a SPECT study.
    Biological psychiatry, 1993, Apr-01, Volume: 33, Issue:7

    Topics: Adult; Brain; Cerebral Cortex; Dominance, Cerebral; Female; Humans; Lactates; Lactic Acid; Male; Org

1993
Valproate treatment of panic disorder and lactate-induced panic attacks.
    Biological psychiatry, 1993, Apr-01, Volume: 33, Issue:7

    Topics: Adult; Arousal; Female; Humans; Lactates; Lactic Acid; Male; Panic; Panic Disorder; Personality Inve

1993
Dorsomedial hypothalamic GABA dysfunction produces physiological arousal following sodium lactate infusions.
    Pharmacology, biochemistry, and behavior, 1996, Volume: 55, Issue:2

    Topics: Allylglycine; Animals; Arousal; Blood Pressure; Dorsomedial Hypothalamic Nucleus; GABA Antagonists;

1996
Consistencies between recalled panic and lactate-induced panic.
    Anxiety, 1994, Volume: 1, Issue:1

    Topics: Adolescent; Adult; Agoraphobia; Arousal; Diagnosis, Differential; Female; Humans; Infusions, Intrave

1994
Single-voxel 1H-MRS investigation of brain metabolic changes during lactate-induced panic.
    Psychiatry research, 1997, Dec-30, Volume: 76, Issue:2-3

    Topics: Adult; Analysis of Variance; Antidepressive Agents, Second-Generation; Brain; Female; Fluoxetine; Hu

1997
Modeling brain compartmental lactate response to metabolic challenge: a feasibility study.
    Psychiatry research, 2000, Feb-28, Volume: 98, Issue:1

    Topics: Adult; Brain; Cerebrospinal Fluid; Echo-Planar Imaging; Feasibility Studies; Female; Humans; Infusio

2000
Post-ECT agitation and plasma lactate concentrations.
    The journal of ECT, 2000, Volume: 16, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia; Anesthetics, Intravenous; Electroconvulsive

2000
D-lactate and the false suffocation alarm.
    Archives of general psychiatry, 2002, Volume: 59, Issue:3

    Topics: Arousal; Asphyxia; Humans; Lactic Acid; Panic; Panic Disorder; Stereoisomerism

2002
[Treatment of patients with panic disorder and an elevated urinary excretion of MHPG using imipramine or clonazepam].
    Investigacion clinica, 1992, Volume: 33, Issue:1

    Topics: Adult; Anxiety Disorders; Clonazepam; Depression; Female; Humans; Imipramine; Lactates; Lactic Acid;

1992
Exercise tolerance in panic disorder patients.
    Biological psychiatry, 1992, Aug-01, Volume: 32, Issue:3

    Topics: Adult; Arousal; Bicarbonates; Carbon Dioxide; Epinephrine; Exercise Test; Female; Heart Rate; Humans

1992
Cortisol response during different anxiogenic challenges in panic disorder patients.
    Psychoneuroendocrinology, 1992, Volume: 17, Issue:5

    Topics: Administration, Oral; Adult; Anxiety Disorders; Arousal; Female; Fenfluramine; Humans; Hydrocortison

1992
Effects of sodium lactate infusion on cisternal lactate and carbon dioxide levels in nonhuman primates.
    The American journal of psychiatry, 1992, Volume: 149, Issue:10

    Topics: Animals; Bicarbonates; Blood; Carbon Dioxide; Humans; Hydrogen-Ion Concentration; Lactates; Lactic A

1992
Noradrenergic function in panic disorder. Effects of intravenous clonidine pretreatment on lactate induced panic.
    Biological psychiatry, 1992, Jan-15, Volume: 31, Issue:2

    Topics: Adult; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Female; Humans; Infusions, Intra

1992
Panic disorder: vascular evaluation with transcranial Doppler ultrasonography.
    Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes, 1991, Volume: 42, Issue:6

    Topics: Adult; Blood Flow Velocity; Cerebral Arteries; Cerebrovascular Circulation; Female; Humans; Lactates

1991
Elevated serum lactate associated with panic attacks induced by hyperventilation.
    Psychiatry research, 1991, Volume: 38, Issue:3

    Topics: Adult; Body Mass Index; Diet; Female; Glycolysis; Heart Rate; Humans; Hydrocortisone; Hyperventilati

1991
Correlation of severity of panic disorder and neuroanatomical changes on magnetic resonance imaging.
    The Journal of neuropsychiatry and clinical neurosciences, 1989,Fall, Volume: 1, Issue:4

    Topics: Adult; Arousal; Clonazepam; Dose-Response Relationship, Drug; Female; Humans; Infusions, Intravenous

1989