lactic acid has been researched along with Osteosarcoma in 34 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Osteosarcoma: A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The salinomycin-loaded PEGylated poly(lactic-co-glycolic acid) nanoparticles (SAL-NP) conjugated with CD133 aptamers (Ap-SAL-NP) were developed by an emulsion/solvent evaporation method, and the targeting and cytotoxicity of Ap-SAL-NP to CD133(+) osteosarcoma CSCs were evaluated." | 7.81 | Poly(lactic-co-glycolic acid) nanoparticles conjugated with CD133 aptamers for targeted salinomycin delivery to CD133+ osteosarcoma cancer stem cells. ( Cai, G; Chen, H; Ni, M; Xiong, M; Yu, Z; Zeng, Q; Zhang, X, 2015) |
| " Present study examines the antitumor potential of paclitaxel (PTX) and etoposide (ETP)-loaded PLGA nanoparticles for the treatment of osteosarcoma." | 7.81 | Paclitaxel and etoposide co-loaded polymeric nanoparticles for the effective combination therapy against human osteosarcoma. ( Wang, B; Xu, M; Xu, SF; Yu, XC, 2015) |
| "In this study, ifosfamide-loaded poly (lactic-co-glycolic acid) (PLGA)-dextran polymeric nanoparticles (PD/IFS) was developed and studied its anticancer efficacy against multiple osteosarcoma cancer cells." | 7.81 | Ifosfamide-loaded poly (lactic-co-glycolic acid) PLGA-dextran polymeric nanoparticles to improve the antitumor efficacy in Osteosarcoma. ( Chen, B; Lin, XJ; Wang, LF; Yang, JZ; Zhang, YJ, 2015) |
| "The present study was to investigate the therapeutic efficacy of the magnetic arsenic trioxide (ATO) nanoparticles against osteosarcoma in vivo tumor models." | 7.74 | Using targeted magnetic arsenic trioxide nanoparticles for osteosarcoma treatment. ( Li, WQ; Li, XS; Wang, WB, 2007) |
| "Osteosarcoma is a bone tumor that affects children and young adults." | 5.39 | Hydrogel-PLGA delivery system prolongs 2-methoxyestradiol-mediated anti-tumor effects in osteosarcoma cells. ( Buenz, CM; Dadsetan, M; Lu, L; Maran, A; Shogren, KL; Yaszemski, MJ, 2013) |
| "In order to prepare a biomimetic nano-carrier which has inflammatory chemotaxis, homologous targeting and reduce immune clearance, for targeted chemotherapy of osteosarcoma, we fabricated the paclitaxel-loaded poly(lactic-co-glycolic) acid (PLGA) nanoparticles coated with 143B-RAW hybrid membrane (PTX-PLGA@[143B-RAW] NPs) and evaluate its anti-cancer efficacy in vitro and vivo." | 4.12 | Hybrid Cell Membrane-Functionalized Biomimetic Nanoparticles for Targeted Therapy of Osteosarcoma. ( Cai, JX; Li, YJ; Liu, JH; Qiu, XH; Wu, JY; Xiang, DX; Xu, P; Xu, WJ, 2022) |
| "The salinomycin-loaded PEGylated poly(lactic-co-glycolic acid) nanoparticles (SAL-NP) conjugated with CD133 aptamers (Ap-SAL-NP) were developed by an emulsion/solvent evaporation method, and the targeting and cytotoxicity of Ap-SAL-NP to CD133(+) osteosarcoma CSCs were evaluated." | 3.81 | Poly(lactic-co-glycolic acid) nanoparticles conjugated with CD133 aptamers for targeted salinomycin delivery to CD133+ osteosarcoma cancer stem cells. ( Cai, G; Chen, H; Ni, M; Xiong, M; Yu, Z; Zeng, Q; Zhang, X, 2015) |
| " Present study examines the antitumor potential of paclitaxel (PTX) and etoposide (ETP)-loaded PLGA nanoparticles for the treatment of osteosarcoma." | 3.81 | Paclitaxel and etoposide co-loaded polymeric nanoparticles for the effective combination therapy against human osteosarcoma. ( Wang, B; Xu, M; Xu, SF; Yu, XC, 2015) |
| "In this study, ifosfamide-loaded poly (lactic-co-glycolic acid) (PLGA)-dextran polymeric nanoparticles (PD/IFS) was developed and studied its anticancer efficacy against multiple osteosarcoma cancer cells." | 3.81 | Ifosfamide-loaded poly (lactic-co-glycolic acid) PLGA-dextran polymeric nanoparticles to improve the antitumor efficacy in Osteosarcoma. ( Chen, B; Lin, XJ; Wang, LF; Yang, JZ; Zhang, YJ, 2015) |
| " In this study, we developed a strategy by localized co-delivery of PLK1shRNA/polylysine-modified polyethylenimine (PEI-Lys) complexes and doxorubicin (DOX) using biodegradable, thermosensitive PLGA-PEG-PLGA hydrogels for treatment of osteosarcoma." | 3.80 | PLK1shRNA and doxorubicin co-loaded thermosensitive PLGA-PEG-PLGA hydrogels for osteosarcoma treatment. ( Chen, X; Cheng, Y; Gong, Y; He, C; Li, D; Liu, J; Ma, H; Tian, H, 2014) |
| " To investigate this hypothesis, we compared the response to an anticancer agent chloroethylnitrosourea (CENU) of two transformed cell lines: HepG2 (hepatocarcinoma) with a partially differentiated phenotype and 143B (osteosarcoma) with an undifferentiated one." | 3.75 | Mitochondrial bioenergetic background confers a survival advantage to HepG2 cells in response to chemotherapy. ( Chevrollier, A; Demidem, A; Douay, O; Loiseau, D; Morvan, D; Reynier, P; Stepien, G, 2009) |
| "The present study was to investigate the therapeutic efficacy of the magnetic arsenic trioxide (ATO) nanoparticles against osteosarcoma in vivo tumor models." | 3.74 | Using targeted magnetic arsenic trioxide nanoparticles for osteosarcoma treatment. ( Li, WQ; Li, XS; Wang, WB, 2007) |
| "The aim of this study was to examine the effect of increased content of 45S5 Bioglass (0-40 wt%) in poly(dl-lactic acid) (PDLLA) porous foams on the behaviour of MG-63 (human osteosarcoma cell line) and A549 cells (human lung carcinoma cell line)." | 3.72 | PDLLA/Bioglass composites for soft-tissue and hard-tissue engineering: an in vitro cell biology assessment. ( Blaker, JJ; Boccaccini, AR; Hench, LL; Maquet, V; Verrier, S, 2004) |
| "Osteosarcoma is the most common primary malignant bone tumor in adolescents and children and prone to develop lung metastasis." | 1.91 | Functional heterogeneity of MCT1 and MCT4 in metabolic reprogramming affects osteosarcoma growth and metastasis. ( Gao, Y; Liu, Y; Sheng, G; Wu, H; Yang, Y, 2023) |
| "To provide novel strategies for future treatment of osteosarcoma, the properties of the scaffold, including its in vitro extended-release properties, the inhibition effects of ADM-PLGA-NHAC on the osteosarcoma MG63 cells, and its bone repair capacity, were investigated in vivo and in vitro." | 1.43 | Porous nano-hydroxyapatite/collagen scaffold containing drug-loaded ADM-PLGA microspheres for bone cancer treatment. ( Cai, BT; Cao, YL; Rong, ZJ; Wu, GF; Yang, LJ; Zhang, ZJ; Zhu, LX, 2016) |
| "Osteosarcoma is a bone tumor that affects children and young adults." | 1.39 | Hydrogel-PLGA delivery system prolongs 2-methoxyestradiol-mediated anti-tumor effects in osteosarcoma cells. ( Buenz, CM; Dadsetan, M; Lu, L; Maran, A; Shogren, KL; Yaszemski, MJ, 2013) |
| "Lactic acid levels, which are a measure of anaerobic metabolism, were found to be > 3 times higher in rho(0) than in wt cells." | 1.31 | Hypersensitization of tumor cells to glycolytic inhibitors. ( Hu, YP; Lampidis, TJ; Liu, H; Priebe, W; Savaraj, N, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (2.94) | 18.2507 |
| 2000's | 8 (23.53) | 29.6817 |
| 2010's | 21 (61.76) | 24.3611 |
| 2020's | 4 (11.76) | 2.80 |
| Authors | Studies |
|---|---|
| Cai, JX | 1 |
| Liu, JH | 1 |
| Wu, JY | 1 |
| Li, YJ | 1 |
| Qiu, XH | 1 |
| Xu, WJ | 1 |
| Xu, P | 1 |
| Xiang, DX | 1 |
| Sheng, G | 1 |
| Gao, Y | 1 |
| Wu, H | 1 |
| Liu, Y | 2 |
| Yang, Y | 1 |
| Wan, J | 1 |
| Long, F | 1 |
| Tian, J | 1 |
| Zhang, C | 1 |
| Yu, B | 1 |
| Zhang, F | 1 |
| Liu, L | 1 |
| Liang, Y | 1 |
| Tang, X | 1 |
| Peng, Y | 1 |
| Cai, F | 1 |
| Zeng, D | 1 |
| Yuan, X | 1 |
| Li, J | 1 |
| Guo, Y | 1 |
| Lv, B | 1 |
| Wang, M | 1 |
| Liao, Q | 1 |
| Lv, XB | 1 |
| Cao, W | 1 |
| Fang, L | 1 |
| Teng, S | 1 |
| Chen, H | 3 |
| Wang, Z | 1 |
| Gao, S | 1 |
| Cheng, C | 1 |
| Chitkara, D | 1 |
| Kumar, N | 1 |
| Cheng, Q | 1 |
| Blais, MO | 1 |
| Harris, GM | 1 |
| Harris, G | 1 |
| Jabbarzadeh, E | 1 |
| Chen, K | 1 |
| Zhu, C | 1 |
| Cai, M | 1 |
| Fu, D | 1 |
| Cheng, B | 1 |
| Cai, Z | 1 |
| Li, G | 1 |
| Liu, J | 2 |
| Ma, H | 1 |
| He, C | 1 |
| Cheng, Y | 1 |
| Li, D | 2 |
| Gong, Y | 1 |
| Tian, H | 1 |
| Chen, X | 1 |
| Yogev, O | 1 |
| Lagos, D | 1 |
| Enver, T | 1 |
| Boshoff, C | 1 |
| Yoneda, T | 1 |
| Hiasa, M | 1 |
| Nagata, Y | 1 |
| Okui, T | 1 |
| White, F | 1 |
| Ni, M | 1 |
| Xiong, M | 1 |
| Zhang, X | 1 |
| Cai, G | 1 |
| Zeng, Q | 1 |
| Yu, Z | 1 |
| Wang, B | 1 |
| Yu, XC | 1 |
| Xu, SF | 1 |
| Xu, M | 1 |
| Stolzoff, M | 1 |
| Webster, TJ | 2 |
| Chen, B | 1 |
| Yang, JZ | 1 |
| Wang, LF | 1 |
| Zhang, YJ | 1 |
| Lin, XJ | 1 |
| Altındal, DÇ | 1 |
| Gümüşderelioğlu, M | 1 |
| Liu, P | 1 |
| Sun, L | 2 |
| Zhou, DS | 1 |
| Zhang, P | 1 |
| Wang, YH | 1 |
| Li, QH | 1 |
| Feng, RJ | 1 |
| Rong, ZJ | 1 |
| Yang, LJ | 1 |
| Cai, BT | 1 |
| Zhu, LX | 1 |
| Cao, YL | 1 |
| Wu, GF | 1 |
| Zhang, ZJ | 1 |
| Jiang, L | 2 |
| Xiong, C | 1 |
| Su, S | 1 |
| Ray, S | 1 |
| Saha, S | 1 |
| Sa, B | 1 |
| Chakraborty, J | 1 |
| Loiseau, D | 1 |
| Morvan, D | 1 |
| Chevrollier, A | 1 |
| Demidem, A | 1 |
| Douay, O | 1 |
| Reynier, P | 1 |
| Stepien, G | 1 |
| Davidson, PM | 1 |
| Fromigué, O | 1 |
| Marie, PJ | 1 |
| Hasirci, V | 1 |
| Reiter, G | 1 |
| Anselme, K | 1 |
| Kankilic, B | 1 |
| Bayramli, E | 1 |
| Kilic, E | 1 |
| Dağdeviren, S | 1 |
| Korkusuz, F | 1 |
| Wang, Y | 1 |
| Zhang, L | 1 |
| Maran, A | 1 |
| Dadsetan, M | 1 |
| Buenz, CM | 1 |
| Shogren, KL | 1 |
| Lu, L | 1 |
| Yaszemski, MJ | 1 |
| Lu, HH | 1 |
| El-Amin, SF | 1 |
| Scott, KD | 1 |
| Laurencin, CT | 1 |
| Verrier, S | 1 |
| Blaker, JJ | 1 |
| Maquet, V | 1 |
| Hench, LL | 1 |
| Boccaccini, AR | 1 |
| Marques, AP | 1 |
| Cruz, HR | 1 |
| Coutinho, OP | 1 |
| Reis, RL | 1 |
| Sosnowski, S | 1 |
| Woźniak, P | 1 |
| Lewandowska-Szumieł, M | 1 |
| Li, XS | 1 |
| Li, WQ | 1 |
| Wang, WB | 1 |
| Dunbar, DR | 1 |
| Moonie, PA | 1 |
| Zeviani, M | 1 |
| Holt, IJ | 1 |
| Toyoda, E | 1 |
| Hiratsuka, M | 1 |
| Nemoto, K | 1 |
| Yoneda, M | 1 |
| Odaka, C | 1 |
| Liu, H | 1 |
| Hu, YP | 1 |
| Savaraj, N | 1 |
| Priebe, W | 1 |
| Lampidis, TJ | 1 |
1 review available for lactic acid and Osteosarcoma
| Article | Year |
|---|---|
Contribution of acidic extracellular microenvironment of cancer-colonized bone to bone pain.
Topics: Acid Sensing Ion Channels; Analgesics; Bone and Bones; Bone Neoplasms; Bone Resorption; Gene Express | 2015 |
33 other studies available for lactic acid and Osteosarcoma
| Article | Year |
|---|---|
Hybrid Cell Membrane-Functionalized Biomimetic Nanoparticles for Targeted Therapy of Osteosarcoma.
Topics: Animals; Biomimetics; Bone Neoplasms; Cell Line, Tumor; Cell Membrane; Drug Carriers; Humans; Lactic | 2022 |
Functional heterogeneity of MCT1 and MCT4 in metabolic reprogramming affects osteosarcoma growth and metastasis.
Topics: Bone Neoplasms; Glucose; Humans; Lactic Acid; Monocarboxylic Acid Transporters; Neoplastic Cells, Ci | 2023 |
circPVT1 promotes osteosarcoma glycolysis and metastasis by sponging miR-423-5p to activate Wnt5a/Ror2 signaling.
Topics: 3' Untranslated Regions; A549 Cells; Animals; Bone Neoplasms; Cell Movement; Cell Proliferation; Glu | 2021 |
The novel prognostic risk factor STC2 can regulate the occurrence and progression of osteosarcoma via the glycolytic pathway.
Topics: Bone Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Computational Biology; Database | 2021 |
Computer-aided discovery and biological characterization of human lactate dehydrogenase 5 inhibitors with anti-osteosarcoma activity.
Topics: Antineoplastic Agents; Catalytic Domain; Cell Line, Tumor; Cell Proliferation; Drug Discovery; Enzym | 2018 |
MiR-323a-3p suppressed the glycolysis of osteosarcoma via targeting LDHA.
Topics: Cell Line; Cell Line, Tumor; Cell Transformation, Neoplastic; Gene Expression; Gene Targeting; Glyco | 2018 |
BSA-PLGA-based core-shell nanoparticles as carrier system for water-soluble drugs.
Topics: Antimetabolites, Antineoplastic; Cell Line, Tumor; Cell Survival; Deoxycytidine; Drug Carriers; Gemc | 2013 |
PLGA-carbon nanotube conjugates for intercellular delivery of caspase-3 into osteosarcoma cells.
Topics: Animals; Apoptosis; Caspase 3; Cattle; Cell Line, Tumor; Drug Carriers; Extracellular Space; Humans; | 2013 |
Integrative metabolome and transcriptome profiling reveals discordant glycolysis process between osteosarcoma and normal osteoblastic cells.
Topics: Biomarkers, Tumor; Case-Control Studies; Cyclic GMP-Dependent Protein Kinase Type I; Down-Regulation | 2014 |
PLK1shRNA and doxorubicin co-loaded thermosensitive PLGA-PEG-PLGA hydrogels for osteosarcoma treatment.
Topics: Animals; Cell Cycle; Cell Cycle Proteins; Cell Death; Cell Line; Cell Survival; Doxorubicin; Gene Ex | 2014 |
Kaposi's sarcoma herpesvirus microRNAs induce metabolic transformation of infected cells.
Topics: Aerobiosis; Blotting, Western; Bone Neoplasms; Cell Proliferation; Endothelial Cells; Endothelium, V | 2014 |
Poly(lactic-co-glycolic acid) nanoparticles conjugated with CD133 aptamers for targeted salinomycin delivery to CD133+ osteosarcoma cancer stem cells.
Topics: AC133 Antigen; Animals; Antigens, CD; Aptamers, Nucleotide; Cell Line, Tumor; Glycoproteins; Lactic | 2015 |
Paclitaxel and etoposide co-loaded polymeric nanoparticles for the effective combination therapy against human osteosarcoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Bone Neoplasms; Cell Cycle; Cell Line, Tu | 2015 |
Reducing bone cancer cell functions using selenium nanocomposites.
Topics: Bone Neoplasms; Cell Line, Tumor; Coated Materials, Biocompatible; Humans; Lactic Acid; Nanocomposit | 2016 |
Ifosfamide-loaded poly (lactic-co-glycolic acid) PLGA-dextran polymeric nanoparticles to improve the antitumor efficacy in Osteosarcoma.
Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Bone Neoplasms; Caspase 3; Cell Line, Tumor; | 2015 |
Melatonin releasing PLGA micro/nanoparticles and their effect on osteosarcoma cells.
Topics: Bone Neoplasms; Cell Line, Tumor; Delayed-Action Preparations; Humans; Lactic Acid; Melatonin; Nanop | 2016 |
Development of Alendronate-conjugated Poly (lactic-co-glycolic acid)-Dextran Nanoparticles for Active Targeting of Cisplatin in Osteosarcoma.
Topics: Alendronate; Animals; Bone Neoplasms; Cell Line, Tumor; Cisplatin; Dextrans; Drug Carriers; Humans; | 2015 |
Porous nano-hydroxyapatite/collagen scaffold containing drug-loaded ADM-PLGA microspheres for bone cancer treatment.
Topics: Animals; Antibiotics, Antineoplastic; Bone Neoplasms; Cell Line, Tumor; Collagen; Doxorubicin; Durap | 2016 |
Improving the degradation behavior and in vitro biological property of nano-hydroxyapatite surface- grafted with the assist of citric acid.
Topics: Biocompatible Materials; Bone Neoplasms; Cell Adhesion; Cell Proliferation; Citric Acid; Durapatite; | 2016 |
In vivo pharmacological evaluation and efficacy study of methotrexate-encapsulated polymer-coated layered double hydroxide nanoparticles for possible application in the treatment of osteosarcoma.
Topics: Aluminum; Animals; Antimetabolites, Antineoplastic; Bone Neoplasms; Cell Line, Tumor; Female; Humans | 2017 |
Mitochondrial bioenergetic background confers a survival advantage to HepG2 cells in response to chemotherapy.
Topics: Adenosine Triphosphate; Carcinoma, Hepatocellular; Cell Differentiation; Cell Proliferation; Cell Re | 2009 |
Topographically induced self-deformation of the nuclei of cells: dependence on cell type and proposed mechanisms.
Topics: Biocompatible Materials; Cell Adhesion; Cell Line, Tumor; Cell Nucleus; Cytological Techniques; Cyto | 2010 |
Vancomycin containing PLLA/β-TCP controls MRSA in vitro.
Topics: Anti-Bacterial Agents; Biocompatible Materials; Bone Substitutes; Calcium Phosphates; Cell Adhesion; | 2011 |
Increased healthy osteoblast to osteosarcoma density ratios on specific PLGA nanopatterns.
Topics: Cell Count; Cell Culture Techniques; Cell Line, Tumor; Humans; Lactic Acid; Microscopy, Atomic Force | 2013 |
Hydrogel-PLGA delivery system prolongs 2-methoxyestradiol-mediated anti-tumor effects in osteosarcoma cells.
Topics: 2-Methoxyestradiol; Antineoplastic Agents, Hormonal; Biocompatible Materials; Cell Cycle Checkpoints | 2013 |
Three-dimensional, bioactive, biodegradable, polymer-bioactive glass composite scaffolds with improved mechanical properties support collagen synthesis and mineralization of human osteoblast-like cells in vitro.
Topics: Biocompatible Materials; Bone Regeneration; Calcium Phosphates; Cell Differentiation; Cell Division; | 2003 |
PDLLA/Bioglass composites for soft-tissue and hard-tissue engineering: an in vitro cell biology assessment.
Topics: Biocompatible Materials; Cell Adhesion; Cell Division; Cell Line, Tumor; Cell Survival; Ceramics; Gl | 2004 |
Effect of starch-based biomaterials on the in vitro proliferation and viability of osteoblast-like cells.
Topics: Biocompatible Materials; Biodegradation, Environmental; Cell Adhesion; Cell Culture Techniques; Cell | 2005 |
Polyester scaffolds with bimodal pore size distribution for tissue engineering.
Topics: Biodegradation, Environmental; Cell Culture Techniques; Cell Line, Tumor; Culture Media; Humans; Lac | 2006 |
Using targeted magnetic arsenic trioxide nanoparticles for osteosarcoma treatment.
Topics: Animals; Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Biological Availability; Ci | 2007 |
Complex I deficiency is associated with 3243G:C mitochondrial DNA in osteosarcoma cell cybrids.
Topics: Cell Fusion; DNA, Mitochondrial; Electron Transport Complex IV; Humans; Hybrid Cells; Lactates; Lact | 1996 |
Immunosuppressant deoxyspergualin affects mitochondrial respiratory function in growing cells.
Topics: Animals; Cell Division; Cell Respiration; Cells, Cultured; DNA, Mitochondrial; Dose-Response Relatio | 2000 |
Hypersensitization of tumor cells to glycolytic inhibitors.
Topics: Anaerobiosis; Antimycin A; Culture Media; Deoxyglucose; Dose-Response Relationship, Drug; Drug Resis | 2001 |