lactic acid and Obesity studies

Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.

Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).

Research Excerpts

Excerpt	Relevance	Reference
"Caffeine ingestion decreases the insulin sensitivity index (ISI) for an oral-glucose-tolerance test (OGTT) and decreases insulin-induced glucose disposal in lean male subjects during a hyperinsulinemic clamp."	9.11	Caffeine ingestion increases the insulin response to an oral-glucose-tolerance test in obese men before and after weight loss. ( Belfie, LM; Chown, SE; Conquer, JA; Duncan, AM; Graham, TE; McLaren, DH; Petrie, HJ, 2004)
"We report 4 cases of lactic acidosis in diabetic patients usually treated with metformin."	7.72	[Metformin-associated lactic acidosis remains a serious complication of metformin therapy]. ( Giunti, C; Grimaud, D; Ichai, C; Levraut, J; Orban, JC, 2003)
"05% tretinoin cream to treat AN associated with obesity."	7.72	Topical therapy with tretinoin and ammonium lactate for acanthosis nigricans associated with obesity. ( Blobstein, SH, 2003)
"Insulin, glucagon, glucose, nonesterified fatty acids (NEFA), and lactate response to oral glucose tolerance test (OGTT, 75 g glucose) and their correlation with mean blood pressure (BP), were studied in 10 normal subjects (N), 25 subjects with abdominal obesity (O), and 9 subjects with abdominal obesity and IGT or non-insulin-dependent diabetes (OD)."	7.70	Response of insulin, glucagon, lactate, and nonesterified fatty acids to glucose in visceral obesity with and without NIDDM: relationship to hypertension. ( Belfiore, F; Campione, R; Iannello, S, 1998)
"As expected, the mice with sucrose-induced obesity had hyperglycemia, hyperinsulinemia, hypertriglyceridemia, hyperleptinemia, and hypozincemia when compared with the mice given the diet alone."	7.70	Zinc-induced hyperleptinemia relates to the amelioration of sucrose-induced obesity with zinc repletion. ( Chen, MD; Lin, PY, 2000)
"The metabolic effects and mechanism of action of metformin are still poorly understood, despite the fact that it has been used to treat patients with non-insulin-dependent diabetes mellitus (NIDDM) for more than 30 years."	7.69	Metabolic effects of metformin in non-insulin-dependent diabetes mellitus. ( Dailey, G; Gerich, JE; Nurjhan, N; Perriello, G; Stumvoll, M, 1995)
"Obesity is a worldwide health problem with rising incidence and results in reproductive difficulties."	5.51	Palmitic acid causes insulin resistance in granulosa cells via activation of JNK. ( Chan, WY; Chen, ZJ; Ke, H; Leung, PCK; Li, W; Lu, G; Qin, Y; Wang, W; Xu, L; You, L; Zhang, X; Zhao, S, 2019)
"Addition of fructose to the diet of normal weight and overweight subjects can increase postprandial plasma triglyceride and uric acid concentration."	5.24	Metabolic Effects of Replacing Sugar-Sweetened Beverages with Artificially-Sweetened Beverages in Overweight Subjects with or without Hepatic Steatosis: A Randomized Control Clinical Trial. ( Boesch, C; Brandejsky, V; Campos, V; Despland, C; Kreis, R; Schneiter, P; Tappy, L, 2017)
"Caffeine ingestion decreases the insulin sensitivity index (ISI) for an oral-glucose-tolerance test (OGTT) and decreases insulin-induced glucose disposal in lean male subjects during a hyperinsulinemic clamp."	5.11	Caffeine ingestion increases the insulin response to an oral-glucose-tolerance test in obese men before and after weight loss. ( Belfie, LM; Chown, SE; Conquer, JA; Duncan, AM; Graham, TE; McLaren, DH; Petrie, HJ, 2004)
"In this study, the effect of Codonopsis lanceolata fermented by lactic acid on controlling gene expression levels related to obesity was observed in an oligonucleotide chip microarray."	3.80	Microarray-based gene expression profiling to elucidate effectiveness of fermented Codonopsis lanceolata in mice. ( Choi, WY; Kim, JS; Lee, HY; Ma, CJ; Park, SJ, 2014)
"Clinical investigations suggest that hepatotoxicity after acetaminophen (APAP) overdose could be more severe in the context of obesity and nonalcoholic fatty liver disease."	3.78	Differences in early acetaminophen hepatotoxicity between obese ob/ob and db/db mice. ( Aubert, J; Begriche, K; Delannoy, M; Fromenty, B; Jaeschke, H; Lepage, S; Lucas-Clerc, C; McGill, MR; Morel, I; Pajaud, J; Ribault, C; Robin, MA; Turlin, B, 2012)
" We studied the metabolic effects of treatment with mildronate, metformin and a combination of the two in the Zucker rat model of obesity and impaired glucose tolerance."	3.77	Anti-diabetic effects of mildronate alone or in combination with metformin in obese Zucker rats. ( Cirule, H; Dambrova, M; Liepinsh, E; Makrecka, M; Skapare, E; Svalbe, B, 2011)
"In order to better understand the impact of reduced mitochondrial function for the development of insulin resistance and cellular metabolism, human myotubes were established from lean, obese, and T2D subjects and exposed to mitochondrial inhibitors, either affecting the electron transport chain (Antimycin A), the ATP synthase (oligomycin) or respiratory uncoupling (2,4-dinitrophenol)."	3.74	Insulin resistance and the mitochondrial link. Lessons from cultured human myotubes. ( Gaster, M, 2007)
"We report 4 cases of lactic acidosis in diabetic patients usually treated with metformin."	3.72	[Metformin-associated lactic acidosis remains a serious complication of metformin therapy]. ( Giunti, C; Grimaud, D; Ichai, C; Levraut, J; Orban, JC, 2003)
"05% tretinoin cream to treat AN associated with obesity."	3.72	Topical therapy with tretinoin and ammonium lactate for acanthosis nigricans associated with obesity. ( Blobstein, SH, 2003)
"The present study was designed to evaluate the effects of aerobic exercise training on glucose tolerance and insulin secretion of obese male Wistar rats (monosodium glutamate [MSG] administration, 4 mg/g-body weight, each other day, from birth to the 14th day)."	3.72	Insulin secretion in monosodium glutamate (MSG) obese rats submitted to aerobic exercise training. ( de Mello, MA; de Souza, CT; Gobatto, CA; Nunes, WM, 2003)
"To determine the impact of insulin resistance and obesity on muscle triacylglycerol (IMTG) and glycogen metabolism during and after prolonged exercise."	3.72	Postexercise muscle triacylglycerol and glycogen metabolism in obese insulin-resistant zucker rats. ( Bruce, CR; Hawley, JA; Kiens, B; Lee, JS, 2004)
" injections of azoxymethane at a dose of 10 mg/kg body weight once weekly for 2 weeks."	3.72	Energy restriction reduces the number of advanced aberrant crypt foci and attenuates the expression of colonic transforming growth factor beta and cyclooxygenase isoforms in Zucker obese (fa/fa) rats. ( Bird, RP; Raju, J, 2003)
" Hypothalamic obesity was induced through administration of monosodium glutamate (MSG) at 4 mg/g of body weight every other day from birth to 14 days old."	3.71	Glucose tolerance and insulin action in monosodium glutamate (MSG) obese exercise-trained rats. ( Braga, LR; de Mello, MA; de Souza, CT; dos Santos, JW; Gobatto, CA; Ribeiro, IA, 2001)
"Insulin, glucagon, glucose, nonesterified fatty acids (NEFA), and lactate response to oral glucose tolerance test (OGTT, 75 g glucose) and their correlation with mean blood pressure (BP), were studied in 10 normal subjects (N), 25 subjects with abdominal obesity (O), and 9 subjects with abdominal obesity and IGT or non-insulin-dependent diabetes (OD)."	3.70	Response of insulin, glucagon, lactate, and nonesterified fatty acids to glucose in visceral obesity with and without NIDDM: relationship to hypertension. ( Belfiore, F; Campione, R; Iannello, S, 1998)
"As expected, the mice with sucrose-induced obesity had hyperglycemia, hyperinsulinemia, hypertriglyceridemia, hyperleptinemia, and hypozincemia when compared with the mice given the diet alone."	3.70	Zinc-induced hyperleptinemia relates to the amelioration of sucrose-induced obesity with zinc repletion. ( Chen, MD; Lin, PY, 2000)
"The metabolic effects and mechanism of action of metformin are still poorly understood, despite the fact that it has been used to treat patients with non-insulin-dependent diabetes mellitus (NIDDM) for more than 30 years."	3.69	Metabolic effects of metformin in non-insulin-dependent diabetes mellitus. ( Dailey, G; Gerich, JE; Nurjhan, N; Perriello, G; Stumvoll, M, 1995)
"The effect of metformin on glucose metabolism was examined in eight obese (percent ideal body weight, 151 +/- 9%) and six lean (percent ideal body weight, 104 +/- 4%) noninsulin-dependent diabetic (NIDD) subjects before and after 3 months of metformin treatment (2."	3.68	Mechanism of metformin action in obese and lean noninsulin-dependent diabetic subjects. ( Barzilai, N; DeFronzo, RA; Simonson, DC, 1991)
"In a population based cohort study 134 type 2 diabetes patients were examined at baseline and 3-year follow-up."	2.75	Low plasma lactate concentration as a biomarker of an incompetent brain-pull: a risk factor for weight gain in type 2 diabetes patients. ( Hitze, B; Hubold, C; Lehnert, H; Marxsen, A; Meier, S; Oltmanns, KM; Pellerin, L; Peters, A; Schweiger, U; van Dyken, R, 2010)
"Persons with type II diabetes mellitus (DM), even without cardiovascular complications have a decreased maximal oxygen consumption (VO2 max) and submaximal oxygen consumption (VO2) during graded exercise compared with healthy controls."	2.69	Abnormal oxygen uptake kinetic responses in women with type II diabetes mellitus. ( Bauer, TA; Brandenburg, SL; Eckel, RH; Hiatt, WR; Regensteiner, JG; Reusch, JE; Sippel, JM; Smith, S; Vogelsong, AM; Wolfel, EE, 1998)
"Defective GS activity in obese NIDDM patients is not secondary to hyperglycemia."	2.69	Irreversibility of the defect in glycogen synthase activity in skeletal muscle from obese patients with NIDDM treated with diet and metformin. ( Beck-Nielsen, H; Damsbo, P; Hermann, LS; Hother-Nielsen, O; Vaag, A, 1998)
"Metformin treatment significantly reduced mean day-time plasma glucose levels (10."	2.66	Metformin improves peripheral but not hepatic insulin action in obese patients with type II diabetes. ( Andersen, PH; Beck-Nielsen, H; Hother-Nielsen, O; Pedersen, O; Schmitz, O, 1989)
"Maternal obesity is associated with an increased risk of adverse pregnancy outcomes including stillbirth, and their etiology is thought to be related to placental and fetal hypoxia."	1.72	Maternal obesity-associated disruption of polarized lactate transporter MCT4 expression in human placenta. ( Atkins, KL; Goetzinger, KR; Shen, WB; Wang, B; Yang, P; Yao, R, 2022)
"Obesity is a globally growing problem."	1.72	Body mass index and labor outcome associated with the level of amniotic fluid lactate. ( Karlsson, S; Patavoukas, E; Sterpu, I; Wallstrom, T; Wiberg-Itzel, E, 2022)
"Obesity is now recognized as a disease."	1.62	Pyruvate dehydrogenase kinase 1 and 2 deficiency reduces high-fat diet-induced hypertrophic obesity and inhibits the differentiation of preadipocytes into mature adipocytes. ( Byeon, JE; Choi, SH; Choi, WI; Go, Y; Ham, HJ; Harris, RA; Jeon, JH; Jeon, YH; Kang, HJ; Kim, DW; Kim, HJ; Kim, MJ; Lee, IK; Lee, JY; Lee, YK; Min, BK; Park, S; Wende, AR, 2021)
"2,584 septic shock patients were enrolled."	1.56	Presentation and outcomes of end stage liver disease patients presenting with septic shock to the emergency department. ( Heffner, AC; Okonkwo, E; Rozario, N, 2020)
"Obesity is a worldwide health problem with rising incidence and results in reproductive difficulties."	1.51	Palmitic acid causes insulin resistance in granulosa cells via activation of JNK. ( Chan, WY; Chen, ZJ; Ke, H; Leung, PCK; Li, W; Lu, G; Qin, Y; Wang, W; Xu, L; You, L; Zhang, X; Zhao, S, 2019)
"Metabolic syndrome is an agglomeration of disorders including obesity, diabetes and cardiovascular diseases and characterized as chronic mild inflammation which elevates the circulatory inflammatory markers."	1.51	High fat diet administration leads to the mitochondrial dysfunction and selectively alters the expression of class 1 GLUT protein in mice. ( Jha, D; Mitra Mazumder, P, 2019)
"Childhood obesity is associated with insulin resistance (IR), increased levels of small dense low-density lipoprotein (sd-LDL) as well as with augmented hepatic de novo lipogenesis, which implies increased triose phosphate fluxes that may lead to increased methylglyoxal (MG) and its catabolic end product D-lactate."	1.48	Higher D-lactate levels are associated with higher prevalence of small dense low-density lipoprotein in obese adolescents. ( Bains, Y; Caccavello, R; Garay-Sevilla, ME; Gugliucci, A; Luevano-Contreras, C; Rodríguez-Mortera, R; Solorio-Meza, S, 2018)
" Therefore, in this study, to overcome extremely low bioavailability of γ-oryzanol with super-high lipophilicity, we encapsulated γ-oryzanol in polymer poly (DL-lactide-co-glycolide) (PLGA) nanoparticles (Nano-Orz), and evaluated its metabolically beneficial impact in genetically obese-diabetic ob/ob mice, the best-known severest diabetic model in mice."	1.46	Marked augmentation of PLGA nanoparticle-induced metabolically beneficial impact of γ-oryzanol on fuel dyshomeostasis in genetically obese-diabetic ob/ob mice. ( Abe, K; Egashira, K; Fukuda, K; Kamei, A; Kinjo, A; Kondo, T; Kozuka, C; Masuzaki, H; Morinaga, H; Nakano, K; Shimizu-Okabe, C; Takayama, C; Yasuoka, A, 2017)
"Glycogen storage disease type Ia is a genetic disorder that is associated with persistent fasting hypoglycemia and the inability to produce endogenous glucose."	1.46	Diabetes mellitus in a patient with glycogen storage disease type Ia: a case report. ( Cohn, A; Ohri, A, 2017)
"Glucose tolerance and hyperinsulinemia improved (P < 0."	1.43	Isocaloric fructose restriction and metabolic improvement in children with obesity and metabolic syndrome. ( Erkin-Cakmak, A; Gugliucci, A; Lustig, RH; Mulligan, K; Noworolski, SM; Schwarz, JM; Tai, VW; Wen, MJ, 2016)
"Patients suffering from type 2 diabetes mellitus (T2DM) often exhibit chronic elevated lactate levels which can promote peripheral insulin resistance by disturbing skeletal muscle insulin-signaling."	1.40	Endurance training alters skeletal muscle MCT contents in T2DM men. ( Bloch, W; Brinkmann, C; Brixius, K; Hellmich, M; Hermann, R; Lenzen, E; Opitz, D; Schiffer, T, 2014)
"Upper-body/visceral obesity is associated with abnormalities of free fatty acid (FFA) metabolism and greater risk of developing type 2 diabetes compared with lower-body obesity."	1.38	Impaired insulin-mediated antilipolysis and lactate release in adipose tissue of upper-body obese women. ( Christiansen, JS; Gormsen, LC; Nellemann, B; Nielsen, S; Sørensen, LP, 2012)
"Maternal obesity was associated with a significant delay in precompaction cell cycle kinetics from the 1-cell stage."	1.38	Parental diet-induced obesity leads to retarded early mouse embryo development and altered carbohydrate utilisation by the blastocyst. ( Binder, NK; Gardner, DK; Mitchell, M, 2012)
"Obesity is a highly prevalent condition associated with several diseases."	1.37	Assessment of aerobic capacity during swimming exercise in ob/ob mice. ( Almeida, WS; Araújo, RC; Barros, CC; Campbell, CS; Cunha, VN; Lima, LC; R Cunha, R; Simões, HG, 2011)
"The prevalence of type 2 diabetes rose across lactate quartiles (11, 14, 20 and 30%; P for trend <0."	1.36	Association of blood lactate with type 2 diabetes: the Atherosclerosis Risk in Communities Carotid MRI Study. ( Astor, BC; Ballantyne, CM; Brancati, FL; Crawford, SO; Hoogeveen, RC; Schmidt, MI; Young, JH, 2010)
"the FGU response to hyperinsulinemia."	1.35	Effects of Intrabrachial metacholine infusion on muscle capillary recruitment and forearm glucose uptake during physiological hyperinsulinemia in obese, insulin-resistant individuals. ( Gudbjörnsdóttir, S; Jansson, PA; Lind, L; Lönnroth, P; Murdolo, G; Sjöstrand, M; Strindberg, L, 2008)
"Insulin resistance in subjects with type 2 diabetes (T2D) and obesity is associated with an imbalance between the availability and the oxidation of lipids."	1.35	Maximal lipid oxidation in patients with type 2 diabetes is normal and shows an adequate increase in response to aerobic training. ( Beck-Nielsen, H; Højlund, K; Mogensen, M; Sahlin, K; Vind, BF, 2009)
"Obesity is associated with altered patterns of substrate utilization at rest and during exercise."	1.33	Lower excess postexercise oxygen consumption and altered growth hormone and cortisol responses to exercise in obese men. ( Harber, V; Wong, T, 2006)
"Acyl-estrone levels were lower than expected in most obese women when compared to those of controls, suggesting an altered availability or function of this hormone."	1.31	Plasma acyl-estrone levels are altered in obese women. ( Alemany, M; Bullo, M; Cabot, C; Fernández-López, JA; García-Lorda, P; Masanés, R; Salas-Salvadó, J, 2000)
"Glycerol release (GR) was used to assess the lipolytic rate and was highest in LW in the abdominal area [0 h: LW, 1."	1.31	Lactate and glycerol release from adipose tissue in lean, obese, and diabetic women from South Africa. ( Boyd, IH; Crowther, NJ; Gray, IP; Joffe, BI; Lönnroth, PN; Schlaphoff, GP; van der Merwe, MT, 2001)
"We studied seven obese subjects with type 2 diabetes and seven lean and seven obese control subjects (fasting plasma glucose levels, 7."	1.30	Glucose production, utilization, and cycling in response to moderate exercise in obese subjects with type 2 diabetes and mild hyperglycemia. ( Giacca, A; Groenewoud, Y; McClean, P; Tsui, E; Zinman, B, 1998)
"Glycerol release was lowered by metformin during the 3-h experiment (P<0."	1.30	Metformin inhibits catecholamine-stimulated lipolysis in obese, hyperinsulinemic, hypertensive subjects in subcutaneous adipose tissue: an in situ microdialysis study. ( Adler, G; Alt, A; Ditschuneit, HH; Flechtner-Mors, M; Jenkinson, CP, 1999)
"Urea levels were highest in controls, and lowest in cafeteria rats fed from day 30, a consequence of the different setting of nitrogen sparing induced by the timing of initiation of cafeteria feeding."	1.29	Long-term effects of cafeteria diet feeding on young Wistar rats. ( Alemany, M; Arola, L; Salvadó, J; Segués, T, 1994)
"Thus, in NIDDM patients, fasting corrects the defect in glycogen storage without modifying the action of insulin on glucose uptake and improves beta-cell responsiveness, the latter two effects being opposite to those observed in nondiabetic subjects."	1.29	Glucose metabolism during the starved-to-fed transition in obese patients with NIDDM. ( Balasse, EO; Féry, F, 1994)
"Obesity is associated with an increased incidence of cardiovascular complications, but the underlying mechanism is unknown."	1.29	Body fat and sympathetic nerve activity in healthy subjects. ( Jéquier, E; Nicod, P; Randin, D; Scherrer, U; Tappy, L; Vollenweider, P, 1994)
"Insulin sensitivity was more tightly associated with glucose, insulin, and lactate levels (both basal and integrated) than obesity per se."	1.28	Insulin resistance in obesity is associated with elevated basal lactate levels and diminished lactate appearance following intravenous glucose and insulin. ( DiGirolamo, M; Gebhart, SS; Lovejoy, J; Newby, FD, 1992)
" Furthermore, 2-deoxyglucose uptake in CS-045-treated adipocytes was increased and the insulin dose-response curve was shifted to the left."	1.27	Characterization of new oral antidiabetic agent CS-045. Studies in KK and ob/ob mice and Zucker fatty rats. ( Fujiwara, T; Horikoshi, H; Ushiyama, I; Yoshioka, S; Yoshioka, T, 1988)
"Muscle insulin resistance was assessed during hindlimb perfusion with a submaximally stimulating concentration of insulin."	1.27	Exercise and diet reduce muscle insulin resistance in obese Zucker rat. ( Cutler, CL; Ivy, JL; Katz, AL; Sherman, WM, 1986)

Research

Studies (213)

Authors

Clinical Trials (14)

Trial Overview

Trial Outcomes

Concentration of Metformin in Adipose Tissue

Timeframe	Studies, this research(%)	All Research%
pre-1990	34 (15.96)	18.7374
1990's	40 (18.78)	18.2507
2000's	46 (21.60)	29.6817
2010's	64 (30.05)	24.3611
2020's	29 (13.62)	2.80

Authors	Studies
Kang, HJ	1
Min, BK	1
Choi, WI	1
Jeon, JH	1
Kim, DW	1
Park, S	1
Lee, YK	1
Kim, HJ	2
Byeon, JE	1
Go, Y	1
Ham, HJ	1
Jeon, YH	1
Kim, MJ	1
Lee, JY	2
Wende, AR	1
Choi, SH	1
Harris, RA	1
Lee, IK	1
Karlsson, S	1
Patavoukas, E	1
Sterpu, I	1
Wallstrom, T	1
Wiberg-Itzel, E	1
Mu, WJ	1
Zhu, JY	1
Chen, M	1
Guo, L	1
Thapa, M	1
Sung, R	1
Heo, YS	1
Lin, Y	1
Bai, M	1
Wang, S	2
Chen, L	1
Li, Z	1
Li, C	1
Cao, P	1
Chen, Y	1
Cai, H	1
Wang, X	1
Zhang, Z	1
Chen, J	1
Wang, F	1
Wang, L	1
Liu, J	1
Farah, H	1
Wijesinghe, SN	1
Nicholson, T	1
Alnajjar, F	1
Certo, M	1
Alghamdi, A	1
Davis, ET	1
Young, SP	1
Mauro, C	1
Jones, SW	1
Saidi, AO	1
Akintayo, CO	1
Atuma, CL	1
Mahmud, H	1
Sabinari, IW	1
Oniyide, AA	1
Aturamu, A	1
Agunbiade, TB	1
Olaniyi, KS	1
Chávez-Guevara, IA	1
Hernández-Torres, RP	1
Trejo-Trejo, M	1
Moreno-Brito, V	1
González-Rodríguez, E	1
Ramos-Jiménez, A	1
Zawada, AE	1
Juchacz, A	1
Palutka, R	1
Zaleśna, K	1
Drużdż, A	1
Dobrowolska, A	1
Domaszewska, K	1
Li, VL	1
He, Y	1
Contrepois, K	1
Liu, H	1
Kim, JT	1
Wiggenhorn, AL	1
Tanzo, JT	1
Tung, AS	1
Lyu, X	1
Zushin, PH	1
Jansen, RS	1
Michael, B	1
Loh, KY	1
Yang, AC	1
Carl, CS	1
Voldstedlund, CT	1
Wei, W	1
Terrell, SM	1
Moeller, BC	1
Arthur, RM	1
Wallis, GA	1
van de Wetering, K	1
Stahl, A	1
Kiens, B	2
Richter, EA	1
Banik, SM	1
Snyder, MP	1
Xu, Y	2
Long, JZ	1
Yao, R	1
Yang, P	2
Goetzinger, KR	1
Atkins, KL	1
Shen, WB	1
Wang, B	1
Lund, J	2
Clemmensen, C	2
Schwartz, TW	1
Feng, T	1
Zhao, X	1
Gu, P	1
Yang, W	1
Wang, C	1
Guo, Q	1
Long, Q	1
Liu, Q	3
Cheng, Y	1
Li, J	1
Cheung, CKY	1
Wu, D	1
Kong, X	1
Ye, D	1
Hua, S	1
Loomes, K	1
Xu, A	1
Hui, X	1
Jevtovic, F	1
Zheng, D	1
Lopez, CA	1
Kern, K	1
Tanner, CJ	2
Jones, TE	1
Pories, WJ	1
Dohm, GL	3
Houmard, JA	3
May, LE	1
Broskey, NT	2
Downing, G	1
Olsen, KF	1
Sawyer, TK	1
Cone, RD	1
Schwendeman, SP	1
Song, EJ	1
Lee, ES	1
Kim, YI	1
Shin, DU	1
Eom, JE	1
Shin, HS	1
Lee, SY	1
Nam, YD	1
Johansen, VBI	1
Gerhart-Hines, Z	1
Okonkwo, E	1
Rozario, N	1
Heffner, AC	1
Zou, K	1
Jagan, N	1
Morrow, LE	1
Walters, RW	1
Plambeck, RW	1
Wallen, TJ	1
Patel, TM	1
Malesker, MA	1
Zhang, H	2
Tong, TK	1
Kong, Z	1
Shi, Q	1
Liu, Y	4
Nie, J	1
Suleiman, JB	1
Nna, VU	1
Zakaria, Z	1
Othman, ZA	1
Eleazu, CO	1
Abu Bakar, AB	1
Ahmad, A	1
Usman, UZ	1
Abdul Rahman, WFW	1
Mohamed, M	1
Yao, Z	1
Yan, Y	1
Zheng, X	1
Wang, M	1
Li, H	2
Chen, W	1
Kalezic, A	1
Udicki, M	1
Srdic Galic, B	1
Aleksic, M	1
Korac, A	1
Jankovic, A	1
Korac, B	1
Broadfield, LA	1
Duarte, JAG	1
Schmieder, R	1
Broekaert, D	1
Veys, K	1
Planque, M	1
Vriens, K	1
Karasawa, Y	1
Napolitano, F	1
Fujita, S	1
Fujii, M	1
Eto, M	1
Holvoet, B	1
Vangoitsenhoven, R	1
Fernandez-Garcia, J	1
Van Elsen, J	1
Dehairs, J	1
Zeng, J	1
Dooley, J	1
Rubio, RA	1
van Pelt, J	1
Grünewald, TGP	1
Liston, A	1
Mathieu, C	1
Deroose, CM	1
Swinnen, JV	1
Lambrechts, D	1
di Bernardo, D	1
Kuroda, S	1
De Bock, K	1
Fendt, SM	1
Hatamoto, Y	1
Yoshimura, E	1
Takae, R	1
Komiyama, T	1
Matsumoto, M	1
Higaki, Y	1
Tanaka, H	2
Wang, Z	1
Wang, QA	1
Jiang, L	1
Gulmez, S	1
Senger, AS	1
Uzun, O	1
Keklikkiran, ZZ	1
Bozkurt, H	1
Omeroglu, S	1
Polat, E	1
Duman, M	1
Patel, DP	1
Krausz, KW	1
Xie, C	1
Beyoğlu, D	1
Gonzalez, FJ	1
Idle, JR	1
Jiang, C	1
Cano-Vega, MA	1
Yue, F	1
Kuang, L	1
Narayanan, N	1
Uzunalli, G	1
Merkel, MP	1
Kuang, S	1
Deng, M	1
Chen, CJ	1
Liao, YH	1
Lin, SY	1
Yu, JX	1
Li, ZJ	1
Lin, YC	1
Chang, GJ	1
Lin, CH	1
Wong, AM	1
Tsai, SF	1
Chen, YW	1
Kuo, YM	1
Cohn, A	1
Ohri, A	1
Kok, B	1
Karvellas, CJ	1
Abraldes, JG	1
Jalan, R	1
Sundaram, V	1
Gurka, D	1
Keenan, S	1
Kumar, A	2
Martinka, G	1
Bookatz, B	1
Wood, G	1
Rodríguez-Mortera, R	1
Luevano-Contreras, C	1
Solorio-Meza, S	1
Caccavello, R	1
Bains, Y	1
Garay-Sevilla, ME	1
Gugliucci, A	2
Cataldo, LR	1
Fernández-Verdejo, R	1
Santos, JL	1
Galgani, JE	1
Unno, Y	1
Yamamoto, H	1
Takatsuki, S	1
Sato, Y	1
Kuranaga, T	1
Yazawa, K	1
Ono, Y	1
Wakimoto, T	1
Hankir, MK	1
Klingenspor, M	1
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de Moraes, SMF	1
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Lavery, LA	1
Hamblin, MR	1
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Zhao, Z	1
Luo, X	1
Liu, C	2
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Zhou, L	1
Buddeberg, BS	1
Sharma, R	1
O'Driscoll, JM	1
Kaelin Agten, A	1
Khalil, A	1
Thilaganathan, B	1
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Koga, S	1
Li, K	1
Sakaue, H	1
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Kim, SW	1
Son, Y	2
Choi, K	1
Kim, SI	1
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Lee, JH	1
Jang, JH	1
Brailsford, AD	1
Majidin, WNM	1
Wojek, N	1
Cowan, DA	1
Walker, C	1
Kim, JH	1
Phi, JH	1
Kim, KH	1
Park, SH	1
Choi, YH	1
Cho, BK	1
Kim, SK	1
Pei, M	1
Ko, JS	1
Ma, MH	1
Park, GE	1
Baek, J	1
Yang, H	1
Cho, MJ	1
Choi, DH	1
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Ho-Palma, AC	1
Romero, MDM	1
Remesar, X	3
Fernández-López, JA	5
Alemany, M	6
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Mitra Mazumder, P	1
Isabelle, SA	1
Ahmed-Ben, M	1
Benoit, C	1
Dominique, D	1
Jérémie, D	1
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Carole, M	1
Estelle, PG	1
Didier, R	1
Sergio, P	1
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Trial	Phase	Enrollment	Study Type	Start Date	Status
Digoxin In Treatment of Alcohol Associated Hepatitis (DIGIT-AlcHep)[NCT05014087]	Phase 2	60 participants (Anticipated)	Interventional	2021-10-08	Recruiting
Optimal Macronutrient Intake - Carbohydrate[NCT00608049]		189 participants (Actual)	Interventional	2008-02-29	Completed
Alkaline Diet for Insulin Sensitivity[NCT02501343]		32 participants (Actual)	Interventional	2015-03-31	Completed
The Relation Between Acute Changes in the Systemic Inflammatory Response, Thiamine and Magnesium Concentrations and Transketolase Activity After Elective Knee Arthroplasty.[NCT03554668]		47 participants (Actual)	Observational	2018-01-15	Completed
Fujian Maternity and Child Health Hospital[NCT02992093]		300 participants (Anticipated)	Observational	2016-12-31	Not yet recruiting
[NCT00200993]	Phase 2	0 participants	Interventional	1998-09-30	Completed
Effect of the Combined (Aerobic/Resisted) and Interval Physical Training on Oxygen Uptake and Heart Rate On-kinetics Responses in Patients With Moderate to Very Severe COPD: Double-blind, Randomized, Controlled Trial[NCT01529489]		40 participants (Actual)	Interventional	2008-01-31	Completed
Metformin Pharmacology in Human Cancers[NCT03477162]	Early Phase 1	18 participants (Actual)	Interventional	2018-05-15	Terminated (stopped due to Enrollment was closed as efforts had become more challenging, and the lab indicated that they were able to obtain their primary objective with the number that had already been enrolled.)
Effectiveness of the Treatment With Dapagliflozin and Metformin Compared to Metformin Monotherapy for Weight Loss on Diabetic and Prediabetic Patients With Obesity Class III[NCT03968224]	Phase 2/Phase 3	90 participants (Anticipated)	Interventional	2018-07-07	Recruiting
Modulation of Insulin Secretion and Insulin Sensitivity in Bangladeshi Type 2 Diabetic Subjects by an Insulin Sensitizer Pioglitazone and T2DM Association With PPARG Gene Polymorphism.[NCT01589445]	Phase 4	77 participants (Actual)	Interventional	2008-11-30	Completed
Gastric Tolerability and Pharmacokinetics of an Extended Release Metformin and an Immediate Release Metformin[NCT00941239]	Phase 1	24 participants (Actual)	Interventional	2007-01-31	Completed
Adaptive Study for Efficacy and Safety of Metformin Glycinate for the Treatment of Patients With MS and DM2, Hospitalized With Severe Acute Respiratory Syndrome Secondary to SARS-CoV-2. Randomized, Double-Blind, Phase IIIb.[NCT04626089]	Phase 2	0 participants (Actual)	Interventional	2021-02-28	Withdrawn (stopped due to Administrative decision of the company)
Metformin Therapy for Overweight Adolescents With Type 1 Diabetes (T1D)--Insulin Clamp Ancillary Study for Assessment of Insulin Resistance[NCT02045290]	Phase 3	37 participants (Actual)	Interventional	2014-01-31	Completed
New Electrophoretic Approaches in Studies of Obesity and Diabetes[NCT03189732]		10 participants (Actual)	Interventional	2015-10-01	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

To determine the concentration of metformin in adipose tissue. (NCT03477162)
Timeframe: Within 7 days from surgery

Concentration of Metformin in Plasma.

Intervention	ng/g (Median)
Metformin	70

To determine the concentration of metformin in plasma. (NCT03477162)
Timeframe: Within 7 days from surgery

Concentration of Metformin in Tumor-adjacent Normal Tissue

Intervention	ng/mL (Median)
Metformin	450

To determine the concentration of metformin in tumor-adjacent normal tissue. (NCT03477162)
Timeframe: Within 7 days from surgery

Concentration of Metformin in Whole Blood.

Intervention	ng/g (Median)
Metformin	749

To determine the concentration of metformin in whole blood. (NCT03477162)
Timeframe: Within 7 days from surgery

Lung Tumor Tissue Concentration of Metformin

Intervention	ng/mL (Median)
Metformin	514

To determine the intra-tumor concentrations of metformin, with a standard deviation ≤25% of the mean, in patients with solid tumors of thoracic origin administered metformin extended release. (NCT03477162)
Timeframe: Within 7 days from surgery

Comparison of Changes in Fasting Serum Glucose (FSG)With Pioglitazone and Metformin

Intervention	ng/g (Median)
Metformin	1290

Response rate was defined by ≥10% decrease of FSG or/and ≥1% decrease of HbA1c from the baseline values after 3 months treatment.48 responded to pioglitazone and 32 responded to metformin. (NCT01589445)
Timeframe: 3 months for each drug

Comparison of Changes in Fasting Serum Insulin (FSI)With Pioglitazone and Metformin

Intervention	mmol/l (Mean)
	Baseline FSG	3rd Month FSG
Metformin ( 002 Group)	6.2	6.5
Pioglitazone (001 Group)	6.9	5.4

Comparison of Changes in Glycosylated Hemoglobin (HbA1c)With Pioglitazone and Metformin

Intervention	μU/ml (Mean)
	Baseline FSI	3rd month FSI
Metformin ( 002 Group)	13.0	13.9
Pioglitazone (001 Group)	16.2	12.3

Comparison of Changes in HOMA Percent B and HOMA Percent S With Pioglitazone and Metformin

Intervention	percentage (Mean)
	Baseline HbA1c	3rd month HbA1c
Metformin ( 002 Group)	7.8	7.0
Pioglitazone (001 Group)	7.3	6.7

"Response rate was defined by ≥10% decrease of FSG or/and ≥1% decrease of HbA1c from the baseline values after 3 months treatment.48 responded to pioglitazone and 32 responded to metformin.~Analysis 1: Homeostatic Model Assessment of Beta cell function(HOMA percent B) Analysis 2: Homeostatic Model Assessment of Insulin Sensitivity (Homa percent S)" (NCT01589445)
Timeframe: 3 months for each drug

Comparison of Changes in Insulin Levels (HOMA IR,QUICKI) With Pioglitazone and Metformin

Intervention	percentage (Mean)
	Baseline HOMA percent beta cells function	3rd month HOMA percent beta cells function	Baseline HOMA percent sensitivity	3rd month HOMA percent sensitivity
Metformin ( 002 Group)	109.3	116.0	76.2	67.2
Pioglitazone (001 Group)	118.9	132.3	51.1	69.3

"Response rate was defined by ≥10% decrease of FSG or/and ≥1% decrease of HbA1c from the baseline values after 3 months treatment.48 responded to pioglitazone and 32 responded to metformin.~Analysis 1: Homeostasis Model Assessment Insulin Resistance(HOMA IR) Analysis 2: Quantitative Insulin sensitivity Check Index(QUICKI)" (NCT01589445)
Timeframe: 3 months for each drug

Comparison of Changes in Lipid Profiles With Pioglitazone and Metformin

Intervention	Score on a scale ( SI unit) (Mean)
	Baseline QUICKI	3rd month QUICKI	Baseline HOMA IR	3rd month HOMA IR
Metformin ( 002 Group)	0.57	0.54	3.7	4.3
Pioglitazone (001 Group)	0.52	0.59	5.1	2.9

"Response rate was defined by ≥10% decrease of FSG or/and ≥1% decrease of HbA1c from the baseline values after 3 months treatment.48 responded to pioglitazone and 32 responded to metformin.~Analysis 1:Total Cholesterol(TC) Analysis 2:Triglyceride(TG) Analysis 3:High Density Lipoprotein(HDL) Analysis 4:Low Density Lipoprotein(LDL)" (NCT01589445)
Timeframe: 3 months for each drug

Intervention	mg/dl (Mean)
	Baseline TC	3rd month TC	Baseline TG	3rd month TG	Baseline HDL	3rd month HDL	Baseline LDL	3rd month LDL
Metformin (002 Group)	193.0	177.0	166.0	175.0	34.4	34.7	125.6	112.0
Pioglitazone (001 Group)	182.0	178	183	195	33	33.2	112.8	105.5

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Exercise-Mediated Browning of White Adipose Tissue: Its Significance, Mechanism and Effectiveness. International journal of molecular sciences, 2021, Oct-26, Volume: 22, Issue:21 Topics: Adipose Tissue, Brown; Adipose Tissue, White; Animals; Energy Metabolism; Exercise; Exercise Therapy	2021
Plasma Lactate as a Marker for Metabolic Health. Exercise and sport sciences reviews, 2020, Volume: 48, Issue:3 Topics: Biomarkers; Citric Acid Cycle; Diabetes Mellitus, Type 2; Fasting; Humans; Lactic Acid; Metabolic Sy	2020
Energy metabolism in brown adipose tissue. The FEBS journal, 2021, Volume: 288, Issue:12 Topics: Adipocytes, Brown; Adipose Tissue, Brown; Amino Acids, Branched-Chain; Animals; Energy Metabolism; F	2021
Brown adipocyte glucose metabolism: a heated subject. EMBO reports, 2018, Volume: 19, Issue:9 Topics: Adipose Tissue, Brown; Animals; Diabetes Mellitus; Drug Discovery; Glucose; Glycolysis; Humans; Lact	2018
Dicarbonyl stress in clinical obesity. Glycoconjugate journal, 2016, Volume: 33, Issue:4 Topics: Animals; Diabetes Mellitus, Type 2; Humans; Lactic Acid; Lactoylglutathione Lyase; Mice; Non-alcohol	2016
Quantitative aspects of L(+)-lactate metabolism in human beings. Ciba Foundation symposium, 1982, Volume: 87 Topics: Animals; Citric Acid Cycle; Fasting; Gluconeogenesis; Humans; Isomerism; Kidney; Lactates; Lactic Ac	1982
Metabolic alterations and lactate overproduction in insulin-resistant states. Advances in experimental medicine and biology, 1994, Volume: 354 Topics: Animals; Glucose; Humans; Insulin Resistance; Lactates; Lactic Acid; Neoplasms; Obesity	1994
Substrate competition and insulin action in animal models. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 2000, Volume: 24 Suppl 2 Topics: Adipose Tissue; Animals; Blood Glucose; Fatty Acids, Nonesterified; Insulin; Insulin Resistance; Ins	2000

Article	Year
Exercise training-induced visceral fat loss in obese women: The role of training intensity and modality. Scandinavian journal of medicine & science in sports, 2021, Volume: 31, Issue:1 Topics: Absorptiometry, Photon; Adolescent; Body Fat Distribution; Diet Records; Energy Metabolism; Epinephr	2021
The effects of breaking sedentary time with different intensity exercise bouts on energy metabolism: A randomized cross-over controlled trial. Nutrition, metabolism, and cardiovascular diseases : NMCD, 2021, 06-07, Volume: 31, Issue:6 Topics: Biomarkers; Blood Glucose; Calorimetry, Indirect; Cross-Over Studies; Energy Intake; Energy Metaboli	2021
GH responses to 2 consecutive bouts of respiratory muscle endurance training in obese adolescents and adults. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2013, Volume: 45, Issue:9 Topics: Adolescent; Adult; Area Under Curve; Breathing Exercises; Demography; Human Growth Hormone; Humans;	2013
Postprandial effects of polydextrose on satiety hormone responses and subjective feelings of appetite in obese participants. Nutrition journal, 2015, Jan-03, Volume: 14 Topics: Adult; Age Factors; Body Mass Index; Cholecystokinin; Cross-Over Studies; Dietary Fats; Dietary Fibe	2015
Effects of Lowering Glycemic Index of Dietary Carbohydrate on Plasma Uric Acid Levels: The OmniCarb Randomized Clinical Trial. Arthritis & rheumatology (Hoboken, N.J.), 2016, Volume: 68, Issue:5 Topics: Adult; Black or African American; Blood Glucose; Cholesterol; Cholesterol, HDL; Cross-Over Studies;	2016
Metabolic Effects of Replacing Sugar-Sweetened Beverages with Artificially-Sweetened Beverages in Overweight Subjects with or without Hepatic Steatosis: A Randomized Control Clinical Trial. Nutrients, 2017, Feb-27, Volume: 9, Issue:3 Topics: Adult; Blood Glucose; Body Mass Index; Diet; Fatty Acids, Nonesterified; Fatty Liver; Female; Glucag	2017
Effects of continuous versus intermittent exercise, obesity, and gender on growth hormone secretion. The Journal of clinical endocrinology and metabolism, 2008, Volume: 93, Issue:12 Topics: Adult; Anaerobic Threshold; Body Composition; Body Mass Index; Data Interpretation, Statistical; Exe	2008
Low plasma lactate concentration as a biomarker of an incompetent brain-pull: a risk factor for weight gain in type 2 diabetes patients. Psychoneuroendocrinology, 2010, Volume: 35, Issue:9 Topics: Adult; Biomarkers; Brain Diseases, Metabolic; Cohort Studies; Diabetes Mellitus, Type 2; Energy Meta	2010
Physical training of 9- to 10-year-old children with obesity to lactate threshold intensity. Pediatric exercise science, 2010, Volume: 22, Issue:3 Topics: Anaerobic Threshold; Analysis of Variance; Child; China; Energy Metabolism; Exercise; Female; Humans	2010
Caffeine ingestion increases the insulin response to an oral-glucose-tolerance test in obese men before and after weight loss. The American journal of clinical nutrition, 2004, Volume: 80, Issue:1 Topics: Administration, Oral; Adult; Area Under Curve; Blood Glucose; C-Peptide; Caffeine; Central Nervous S	2004
Exercise training increases electron and substrate shuttling proteins in muscle of overweight men and women with the metabolic syndrome. Journal of applied physiology (Bethesda, Md. : 1985), 2005, Volume: 98, Issue:1 Topics: Adult; Blood Glucose; Exercise; Female; Gene Expression Regulation; Humans; Lactic Acid; Male; Metab	2005
Influences of AT1 receptor blockade on tissue metabolism in obese men. American journal of physiology. Regulatory, integrative and comparative physiology, 2006, Volume: 290, Issue:1 Topics: Adipose Tissue; Adult; Angiotensin II Type 1 Receptor Blockers; Biphenyl Compounds; Cross-Over Studi	2006
Studies of phosphodiesterase effects on adipose tissue metabolism in obese subjects by the microdialysis technique. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2005, Volume: 56, Issue:3 Topics: Adipose Tissue; Adrenergic alpha-Agonists; Adult; Cyclic AMP; Electric Impedance; Female; Glucose; G	2005
The effect of oral glucose loads on tissue metabolism during angiotensin II receptor and beta-receptor blockade in obese hypertensive subjects. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2006, Volume: 38, Issue:5 Topics: Adipose Tissue; Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Atenolol; Blo	2006
Lactate release from adipose tissue and skeletal muscle in vivo: defective insulin regulation in insulin-resistant obese women. American journal of physiology. Endocrinology and metabolism, 2007, Volume: 292, Issue:3 Topics: Adipose Tissue; Adult; Basal Metabolism; Blood Glucose; Female; Glucose Clamp Technique; Humans; Ins	2007
Effect of weight loss on lactate transporter expression in skeletal muscle of obese subjects. Journal of applied physiology (Bethesda, Md. : 1985), 2008, Volume: 104, Issue:3 Topics: Adult; Anti-Obesity Agents; Blood Glucose; Caloric Restriction; Citrate (si)-Synthase; Female; Fenfl	2008
Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. The Multicenter Metformin Study Group. The New England journal of medicine, 1995, Aug-31, Volume: 333, Issue:9 Topics: Blood Glucose; Body Weight; Cholesterol; Diabetes Mellitus; Diabetes Mellitus, Type 2; Double-Blind	1995
Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. The Multicenter Metformin Study Group. The New England journal of medicine, 1995, Aug-31, Volume: 333, Issue:9 Topics: Blood Glucose; Body Weight; Cholesterol; Diabetes Mellitus; Diabetes Mellitus, Type 2; Double-Blind	1995
Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. The Multicenter Metformin Study Group. The New England journal of medicine, 1995, Aug-31, Volume: 333, Issue:9 Topics: Blood Glucose; Body Weight; Cholesterol; Diabetes Mellitus; Diabetes Mellitus, Type 2; Double-Blind	1995
Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. The Multicenter Metformin Study Group. The New England journal of medicine, 1995, Aug-31, Volume: 333, Issue:9 Topics: Blood Glucose; Body Weight; Cholesterol; Diabetes Mellitus; Diabetes Mellitus, Type 2; Double-Blind	1995
Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. The Multicenter Metformin Study Group. The New England journal of medicine, 1995, Aug-31, Volume: 333, Issue:9 Topics: Blood Glucose; Body Weight; Cholesterol; Diabetes Mellitus; Diabetes Mellitus, Type 2; Double-Blind	1995
Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. The Multicenter Metformin Study Group. The New England journal of medicine, 1995, Aug-31, Volume: 333, Issue:9 Topics: Blood Glucose; Body Weight; Cholesterol; Diabetes Mellitus; Diabetes Mellitus, Type 2; Double-Blind	1995
Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. The Multicenter Metformin Study Group. The New England journal of medicine, 1995, Aug-31, Volume: 333, Issue:9 Topics: Blood Glucose; Body Weight; Cholesterol; Diabetes Mellitus; Diabetes Mellitus, Type 2; Double-Blind	1995
Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. The Multicenter Metformin Study Group. The New England journal of medicine, 1995, Aug-31, Volume: 333, Issue:9 Topics: Blood Glucose; Body Weight; Cholesterol; Diabetes Mellitus; Diabetes Mellitus, Type 2; Double-Blind	1995
Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. The Multicenter Metformin Study Group. The New England journal of medicine, 1995, Aug-31, Volume: 333, Issue:9 Topics: Blood Glucose; Body Weight; Cholesterol; Diabetes Mellitus; Diabetes Mellitus, Type 2; Double-Blind	1995
Substrate utilization during prolonged exercise in obese women differing in body fat distribution. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 1994, Volume: 18, Issue:4 Topics: Adipose Tissue; Adolescent; Adrenergic beta-Antagonists; Adult; Anthropometry; Body Composition; Bod	1994
Abnormal oxygen uptake kinetic responses in women with type II diabetes mellitus. Journal of applied physiology (Bethesda, Md. : 1985), 1998, Volume: 85, Issue:1 Topics: Adult; Autonomic Nervous System; Body Composition; Densitometry; Diabetes Mellitus; Diabetes Mellitu	1998
Irreversibility of the defect in glycogen synthase activity in skeletal muscle from obese patients with NIDDM treated with diet and metformin. Diabetes care, 1998, Volume: 21, Issue:9 Topics: Adult; Blood Glucose; Body Weight; Calorimetry, Indirect; Diabetes Mellitus; Diabetes Mellitus, Type	1998
Lactate and glycerol release from the subcutaneous adipose tissue of obese urban women from South Africa; important metabolic implications. The Journal of clinical endocrinology and metabolism, 1998, Volume: 83, Issue:11 Topics: Adipose Tissue; Adult; Black People; Blood Flow Velocity; Body Constitution; Female; Glucose; Glycer	1998
Effects of mental stress on insulin-mediated glucose metabolism and energy expenditure in lean and obese women. American journal of physiology. Endocrinology and metabolism, 2000, Volume: 279, Issue:4 Topics: Adrenergic beta-Antagonists; Adult; Blood Pressure; Cardiac Output; Energy Metabolism; Epinephrine;	2000
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Pyruvate dehydrogenase kinase 1 and 2 deficiency reduces high-fat diet-induced hypertrophic obesity and inhibits the differentiation of preadipocytes into mature adipocytes. Experimental & molecular medicine, 2021, Volume: 53, Issue:9 Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Adiposity; Animals; Biomarkers; Cell Differentiation; Diet,	2021
Body mass index and labor outcome associated with the level of amniotic fluid lactate. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2022, Volume: 35, Issue:25 Topics: Amniotic Fluid; Body Mass Index; Cesarean Section; Cross-Sectional Studies; Dystocia; Female; Humans	2022
A Dual Electrode Biosensor for Glucose and Lactate Measurement in Normal and Prolonged Obese Mice Using Single Drop of Whole Blood. Biosensors, 2021, Dec-09, Volume: 11, Issue:12 Topics: Animals; Biosensing Techniques; Blood Glucose; Electrodes; Enzymes, Immobilized; Glucose; Glucose Ox	2021
Lactate Is a Key Mediator That Links Obesity to Insulin Resistance via Modulating Cytokine Production From Adipose Tissue. Diabetes, 2022, 04-01, Volume: 71, Issue:4 Topics: Adipose Tissue; Animals; Cytokines; Diet, High-Fat; Inflammation; Insulin Resistance; Lactic Acid; M	2022
Moderate l-lactate administration suppresses adipose tissue macrophage M1 polarization to alleviate obesity-associated insulin resistance. The Journal of biological chemistry, 2022, Volume: 298, Issue:4 Topics: Adipose Tissue; AMP-Activated Protein Kinases; Animals; Diabetes Mellitus, Type 2; Diet, High-Fat; I	2022
Differential Metabotypes in Synovial Fibroblasts and Synovial Fluid in Hip Osteoarthritis Patients Support Inflammatory Responses. International journal of molecular sciences, 2022, Mar-17, Volume: 23, Issue:6 Topics: Cells, Cultured; Fibroblasts; Glutamic Acid; Glutamine; Humans; Lactic Acid; Obesity; Osteoarthritis	2022
Melatonin supplementation preserves testicular function by attenuating lactate production and oxidative stress in high fat diet-induced obese rat model. Theriogenology, 2022, Jul-15, Volume: 187 Topics: Animals; Antioxidants; Diet, High-Fat; Dietary Supplements; Glutathione Peroxidase; Lactic Acid; Mal	2022
Association Among Different Aerobic Threshold Markers and FATmax in Men With Obesity. Research quarterly for exercise and sport, 2023, Volume: 94, Issue:3 Topics: Calorimetry, Indirect; Exercise Test; Humans; Lactic Acid; Lipid Metabolism; Male; Obesity; Oxygen C	2023
The effect of breathing an oxygen-enriched mixture on tissue saturation in obese women. Advances in clinical and experimental medicine : official organ Wroclaw Medical University, 2022, Volume: 31, Issue:9 Topics: Exercise; Female; Humans; Lactic Acid; Obesity; Oxygen; Oxygen Consumption	2022
An exercise-inducible metabolite that suppresses feeding and obesity. Nature, 2022, Volume: 606, Issue:7915 Topics: Adiposity; Animals; Body Weight; Diabetes Mellitus, Type 2; Disease Models, Animal; Eating; Energy M	2022
Maternal obesity-associated disruption of polarized lactate transporter MCT4 expression in human placenta. Reproductive toxicology (Elmsford, N.Y.), 2022, Volume: 112 Topics: Female; Humans; Lactic Acid; Monocarboxylic Acid Transporters; Muscle Proteins; Obesity; Obesity, Ma	2022
Outrunning obesity with Lac-Phe? Cell metabolism, 2022, 08-02, Volume: 34, Issue:8 Topics: Exercise; Humans; Lactic Acid; Muscle, Skeletal; Obesity; Phenylalanine	2022
Adipocyte-derived lactate is a signalling metabolite that potentiates adipose macrophage inflammation via targeting PHD2. Nature communications, 2022, 09-05, Volume: 13, Issue:1 Topics: Adipocytes; Adipose Tissue; Animals; Humans; Hypoxia-Inducible Factor-Proline Dioxygenases; Inflamma	2022
Greater reliance on glycolysis is associated with lower mitochondrial substrate oxidation and insulin sensitivity in infant myogenic MSCs. American journal of physiology. Endocrinology and metabolism, 2023, 09-01, Volume: 325, Issue:3 Topics: Carbon Dioxide; Glucose; Glycolysis; Humans; Insulin; Insulin Resistance; Lactic Acid; Mesenchymal S	2023
Aqueous remote loading of setmelanotide in poly(lactic-co-glycolic acid) microspheres for long-term obesity treatment. Journal of controlled release : official journal of the Controlled Release Society, 2023, Volume: 364 Topics: alpha-MSH; Animals; Body Weight; Delayed-Action Preparations; Disease Models, Animal; Drug Carriers;	2023
Gut microbial change after administration of Frontiers in endocrinology, 2023, Volume: 14 Topics: Animals; Disease Models, Animal; Dysbiosis; Gastrointestinal Microbiome; Lactic Acid; Lacticaseibaci	2023
Is lactate a driver of skin burn-induced adipose browning? American journal of physiology. Endocrinology and metabolism, 2023, 10-01, Volume: 325, Issue:4 Topics: Adiposity; Burns; Humans; Lactic Acid; Obesity	2023
Presentation and outcomes of end stage liver disease patients presenting with septic shock to the emergency department. The American journal of emergency medicine, 2020, Volume: 38, Issue:7 Topics: Acute Kidney Injury; Adolescent; Adult; Age Distribution; Aged; Aged, 80 and over; APACHE; Body Temp	2020
Sepsis and the Obesity Paradox: Size Matters in More Than One Way. Critical care medicine, 2020, Volume: 48, Issue:9 Topics: Age Factors; Aged; Aged, 80 and over; APACHE; Arterial Pressure; Body Mass Index; Body Weight; Comor	2020
Protective effects of bee bread on testicular oxidative stress, NF-κB-mediated inflammation, apoptosis and lactate transport decline in obese male rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020, Volume: 131 Topics: Animals; Antioxidants; Apoptosis; Bees; Diet, High-Fat; Down-Regulation; Inflammation; L-Lactate Deh	2020
Dietary Lactate Supplementation Protects against Obesity by Promoting Adipose Browning in Mice. Journal of agricultural and food chemistry, 2020, Dec-16, Volume: 68, Issue:50 Topics: Adipose Tissue, Brown; Animals; Dietary Supplements; Energy Metabolism; Humans; Lactic Acid; Male; M	2020
Lactate Metabolism in Breast Cancer Microenvironment: Contribution Focused on Associated Adipose Tissue and Obesity. International journal of molecular sciences, 2020, Dec-18, Volume: 21, Issue:24 Topics: Adipose Tissue; Adult; Breast Neoplasms; Carcinoma, Ductal, Breast; Female; Follow-Up Studies; Human	2020
Fat Induces Glucose Metabolism in Nontransformed Liver Cells and Promotes Liver Tumorigenesis. Cancer research, 2021, 04-15, Volume: 81, Issue:8 Topics: Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Citric Acid Cycle; Diet, High-F	2021
The risk factors of intraoperative hyperlactatemia in patients undergoing laparoscopic colorectal surgery. Annali italiani di chirurgia, 2021, Volume: 92 Topics: Adult; Aged; Aged, 80 and over; Colorectal Neoplasms; Female; Humans; Hyperlactatemia; Lactic Acid;	2021
Metabolic profiling by gas chromatography-mass spectrometry of energy metabolism in high-fat diet-fed obese mice. PloS one, 2017, Volume: 12, Issue:5 Topics: Animals; Blood Chemical Analysis; Citric Acid; Diet, High-Fat; Energy Metabolism; Fatty Acids; Gas C	2017
Dibenzazepine-Loaded Nanoparticles Induce Local Browning of White Adipose Tissue to Counteract Obesity. Molecular therapy : the journal of the American Society of Gene Therapy, 2017, 07-05, Volume: 25, Issue:7 Topics: Adipose Tissue, Brown; Adipose Tissue, White; Animals; Anti-Obesity Agents; Apoptosis Regulatory Pro	2017
Diet-induced obesity accelerates blood lactate accumulation of rats in response to incremental exercise to maximum. American journal of physiology. Regulatory, integrative and comparative physiology, 2017, Nov-01, Volume: 313, Issue:5 Topics: Adaptation, Physiological; Animals; Biomarkers; Diet, High-Fat; Disease Models, Animal; Energy Metab	2017
High-fat diet reduces the hippocampal content level of lactate which is correlated with the expression of glial glutamate transporters. Neuroscience letters, 2018, Jan-01, Volume: 662 Topics: Animals; Diet, High-Fat; Disease Models, Animal; Excitatory Amino Acid Transporter 1; Excitatory Ami	2018
Diabetes mellitus in a patient with glycogen storage disease type Ia: a case report. Journal of medical case reports, 2017, Nov-12, Volume: 11, Issue:1 Topics: Acarbose; Adult; Blood Glucose; Canagliflozin; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobi	2017
The impact of obesity in cirrhotic patients with septic shock: A retrospective cohort study. Liver international : official journal of the International Association for the Study of the Liver, 2018, Volume: 38, Issue:7 Topics: Aged; Body Mass Index; Canada; Comorbidity; Critical Illness; Databases, Factual; Female; Hospital M	2018
Higher D-lactate levels are associated with higher prevalence of small dense low-density lipoprotein in obese adolescents. Clinical chemistry and laboratory medicine, 2018, 06-27, Volume: 56, Issue:7 Topics: Adolescent; Biomarkers; Body Mass Index; Carotid Intima-Media Thickness; Cross-Sectional Studies; Dy	2018
Plasma MOTS-c levels are associated with insulin sensitivity in lean but not in obese individuals. Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 2018, Volume: 66, Issue:6 Topics: Adult; Female; Humans; Insulin Resistance; Lactic Acid; Male; Mitochondrial Proteins; Obesity; Thinn	2018
Palmitoyl lactic acid induces adipogenesis and a brown fat-like phenotype in 3T3-L1 preadipocytes. Biochimica et biophysica acta. Molecular and cell biology of lipids, 2018, Volume: 1863, Issue:7 Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Adipose Tissue, Brown; Animals; Cell Differentiation; Lactic	2018
Cafeteria Diet Feeding in Young Rats Leads to Hepatic Steatosis and Increased Gluconeogenesis under Fatty Acids and Glucagon Influence. Nutrients, 2018, Oct-23, Volume: 10, Issue:11 Topics: Animals; Diet; Energy Intake; Fatty Acids; Fatty Liver; Feeding Behavior; Glucagon; Gluconeogenesis;	2018
Journal of textile science & engineering, 2018, Volume: 8, Issue:2 Topics: Adult; Anabolic Agents; Androgens; Animals; Anthraquinones; Birth Weight; Body Mass Index; Carbon Is	2018
Higher lactate production from glucose in cultured adipose nucleated stromal cells than for rat adipocytes. Adipocyte, 2019, Volume: 8, Issue:1 Topics: Adipocytes; Adipose Tissue; Adipose Tissue, White; Adiposity; Animals; Cell Line; Cells, Cultured; F	2019
High fat diet administration leads to the mitochondrial dysfunction and selectively alters the expression of class 1 GLUT protein in mice. Molecular biology reports, 2019, Volume: 46, Issue:2 Topics: Adipose Tissue; Animals; Body Weight; Diet, High-Fat; Gene Expression Regulation; Glucose Transporte	2019
Profound Changes in Net Energy and Nitrogen Metabolites Fluxes within the Splanchnic Area during Overfeeding of Yucatan Mini Pigs That Remain Euglycemic. Nutrients, 2019, Feb-19, Volume: 11, Issue:2 Topics: Adaptation, Physiological; Amino Acids; Animals; Bile; Blood Glucose; Carbohydrate Metabolism; Energ	2019
Palmitic acid causes insulin resistance in granulosa cells via activation of JNK. Journal of molecular endocrinology, 2019, Volume: 62, Issue:4 Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Survival; Fatty Acids; Female; Glucose; Granulosa Cells;	2019
Short bouts of anaerobic exercise increase non-esterified fatty acids release in obesity. European journal of nutrition, 2014, Volume: 53, Issue:1 Topics: Adult; Blood Glucose; Body Composition; Body Mass Index; Exercise; Fatty Acids, Nonesterified; Feedi	2014
The association of plasma lactate with incident cardiovascular outcomes: the ARIC Study. American journal of epidemiology, 2013, Aug-01, Volume: 178, Issue:3 Topics: Alcohol Drinking; Biomarkers; Community-Based Participatory Research; Comorbidity; Coronary Disease;	2013
Exercise training at MLSS decreases weight gain and increases aerobic capacity in obese Zucker rats. International journal of sports medicine, 2014, Volume: 35, Issue:3 Topics: Animals; Disease Models, Animal; Exercise Therapy; Female; Lactic Acid; Male; Obesity; Oxygen Consum	2014
Plasma volume variation with exercise: a crucial consideration for obese adolescent boys. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 2014, Volume: 39, Issue:1 Topics: Adolescent; Blood Glucose; Exercise; Humans; Lactic Acid; Male; Obesity; Plasma Volume	2014
Effects of exercise training on indicators of adipose tissue angiogenesis and hypoxia in obese rats. Metabolism: clinical and experimental, 2014, Volume: 63, Issue:4 Topics: Adipose Tissue; Animals; Biomarkers; Hypoxia; Lactic Acid; Male; Neovascularization, Pathologic; Obe	2014
Microarray-based gene expression profiling to elucidate effectiveness of fermented Codonopsis lanceolata in mice. International journal of molecular sciences, 2014, Apr-08, Volume: 15, Issue:4 Topics: Animals; Calcium-Binding Proteins; Codonopsis; Cytochrome P-450 Enzyme System; DNA-Binding Proteins;	2014
Increased adipocyte O2 consumption triggers HIF-1α, causing inflammation and insulin resistance in obesity. Cell, 2014, Jun-05, Volume: 157, Issue:6 Topics: Adenine Nucleotide Translocator 2; Adipocytes; Animals; Basic Helix-Loop-Helix Transcription Factors	2014
Endurance training alters skeletal muscle MCT contents in T2DM men. International journal of sports medicine, 2014, Volume: 35, Issue:13 Topics: Aged; Body Mass Index; Diabetes Mellitus, Type 2; Humans; Lactic Acid; Male; Middle Aged; Monocarbox	2014
Hormonal and metabolic responses to a resistance exercise protocol in lean children, obese children and lean adults. Pediatric exercise science, 2014, Volume: 26, Issue:4 Topics: Adult; Blood Glucose; Blood Pressure; Child; Epinephrine; Fatty Acids, Nonesterified; Female; Glycer	2014
Altered metabolic and stemness capacity of adipose tissue-derived stem cells from obese mouse and human. PloS one, 2015, Volume: 10, Issue:4 Topics: Adipocytes; Adipose Tissue; Adult; Animals; Base Sequence; Body Mass Index; Cell Proliferation; Cell	2015
Plasma Lactate Levels Increase during Hyperinsulinemic Euglycemic Clamp and Oral Glucose Tolerance Test. Journal of diabetes research, 2015, Volume: 2015 Topics: Adult; Blood Glucose; Body Mass Index; Female; Glucose Clamp Technique; Glucose Tolerance Test; Glyc	2015
Isocaloric fructose restriction and metabolic improvement in children with obesity and metabolic syndrome. Obesity (Silver Spring, Md.), 2016, Volume: 24, Issue:2 Topics: Absorptiometry, Photon; Adiposity; Adolescent; Black or African American; Blood Pressure; Body Weigh	2016
Enhancement of energy production by black ginger extract containing polymethoxy flavonoids in myocytes through improving glucose, lactic acid and lipid metabolism. Journal of natural medicines, 2016, Volume: 70, Issue:2 Topics: AMP-Activated Protein Kinases; Animals; Cell Line; Deoxyglucose; Energy Metabolism; Flavonoids; Gluc	2016
Obesity inhibits the osteogenic differentiation of human adipose-derived stem cells. Journal of translational medicine, 2016, Jan-27, Volume: 14 Topics: Adipose Tissue; Adult; Animals; Cell Differentiation; Collagen; Female; Gene Expression Profiling; G	2016
Fragmented Lactic Acid Bacterial Cells Activate Peroxisome Proliferator-Activated Receptors and Ameliorate Dyslipidemia in Obese Mice. Journal of agricultural and food chemistry, 2016, Mar-30, Volume: 64, Issue:12 Topics: Animals; Atherosclerosis; Dyslipidemias; Insulin Resistance; Lactic Acid; Lipoproteins, HDL; Lipopro	2016
Mass Spectrometry Imaging Reveals Elevated Glomerular ATP/AMP in Diabetes/obesity and Identifies Sphingomyelin as a Possible Mediator. EBioMedicine, 2016, Volume: 7 Topics: Adenosine Monophosphate; Adenosine Triphosphate; AMP-Activated Protein Kinases; Animals; Cell Line;	2016
Plasma Irisin Modestly Increases during Moderate and High-Intensity Afternoon Exercise in Obese Females. PloS one, 2017, Volume: 12, Issue:1 Topics: Adult; Blood Glucose; Body Mass Index; C-Peptide; Exercise; Female; Fibronectins; Gene Expression; G	2017
Marked augmentation of PLGA nanoparticle-induced metabolically beneficial impact of γ-oryzanol on fuel dyshomeostasis in genetically obese-diabetic ob/ob mice. Drug delivery, 2017, Volume: 24, Issue:1 Topics: Administration, Oral; Animals; Behavior, Animal; Blood Glucose; Diabetes Mellitus; Disease Models, A	2017
Exercise timing and blood lactate concentrations in individuals with type 2 diabetes. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 2017, Volume: 42, Issue:7 Topics: Adult; Blood Glucose; Body Mass Index; Diabetes Mellitus, Type 2; Diet; Female; Humans; Hypoglycemic	2017
Association of lactate with blood pressure before and after rapid weight loss. American journal of hypertension, 2008, Volume: 21, Issue:12 Topics: Adipose Tissue; Adult; Aged; Biomarkers; Blood Pressure; Body Mass Index; Case-Control Studies; Diet	2008
Post-exercise heart rate recovery in healthy, obeses, and COPD subjects: relationships with blood lactic acid and PaO2 levels. Clinical research in cardiology : official journal of the German Cardiac Society, 2009, Volume: 98, Issue:1 Topics: Adult; Bicycling; Cardiovascular Diseases; Exercise Test; Female; Heart Rate; Humans; Lactic Acid; M	2009
Obesity, weight loss, and cardiovascular health: is oxidative capacity a missing link? American journal of hypertension, 2008, Volume: 21, Issue:12 Topics: Biomarkers; Cardiovascular Diseases; Coronary Disease; Evidence-Based Medicine; Humans; Hypertension	2008
Maximal lipid oxidation in patients with type 2 diabetes is normal and shows an adequate increase in response to aerobic training. Diabetes, obesity & metabolism, 2009, Volume: 11, Issue:9 Topics: Citrate (si)-Synthase; Diabetes Mellitus, Type 2; Energy Metabolism; Exercise; Female; Glucose; Huma	2009
1H-nuclear magnetic resonance spectroscopy-based metabolic assessment in a rat model of obesity induced by a high-fat diet. Analytical and bioanalytical chemistry, 2009, Volume: 395, Issue:4 Topics: Acetoacetates; Acetone; Animals; Betaine; Citric Acid; Dietary Fats; Disease Models, Animal; Glycine	2009
Complications but not obesity or diabetes mellitus have impact on the intraperitoneal lactate/pyruvate ratio measured by microdialysis. Scandinavian journal of gastroenterology, 2010, Volume: 45, Issue:1 Topics: Aged; Aged, 80 and over; Diabetes Complications; Female; Humans; Lactic Acid; Male; Microdialysis; M	2010
Variation in characteristics of islets of Langerhans in insulin-resistant, diabetic and non-diabetic-rat strains. International journal of experimental pathology, 2010, Volume: 91, Issue:3 Topics: Animals; Blood Glucose; Cholesterol; Diabetes Mellitus, Type 2; Enzyme-Linked Immunosorbent Assay; F	2010
Metabolic profiling of muscle contraction in lean compared with obese rodents. American journal of physiology. Regulatory, integrative and comparative physiology, 2010, Volume: 299, Issue:3 Topics: Acetyl-CoA Carboxylase; Animals; Biological Transport; Carnitine; Glucose; Glycogen; Lactic Acid; Li	2010
Chronically increased glucose uptake by adipose tissue leads to lactate production and improved insulin sensitivity rather than obesity in the mouse. Diabetologia, 2010, Volume: 53, Issue:11 Topics: 3T3-L1 Cells; Adipose Tissue; Animals; Blotting, Northern; Cells, Cultured; Glucokinase; Glucose; Gl	2010
Association of blood lactate with type 2 diabetes: the Atherosclerosis Risk in Communities Carotid MRI Study. International journal of epidemiology, 2010, Volume: 39, Issue:6 Topics: Aged; Aged, 80 and over; Atherosclerosis; Body Mass Index; Carotid Arteries; Cross-Sectional Studies	2010
Association of blood lactate with type 2 diabetes: the Atherosclerosis Risk in Communities Carotid MRI Study. International journal of epidemiology, 2010, Volume: 39, Issue:6 Topics: Aged; Aged, 80 and over; Atherosclerosis; Body Mass Index; Carotid Arteries; Cross-Sectional Studies	2010
Association of blood lactate with type 2 diabetes: the Atherosclerosis Risk in Communities Carotid MRI Study. International journal of epidemiology, 2010, Volume: 39, Issue:6 Topics: Aged; Aged, 80 and over; Atherosclerosis; Body Mass Index; Carotid Arteries; Cross-Sectional Studies	2010
Association of blood lactate with type 2 diabetes: the Atherosclerosis Risk in Communities Carotid MRI Study. International journal of epidemiology, 2010, Volume: 39, Issue:6 Topics: Aged; Aged, 80 and over; Atherosclerosis; Body Mass Index; Carotid Arteries; Cross-Sectional Studies	2010
Interaction between maternal obesity and post-natal over-nutrition on skeletal muscle metabolism. Nutrition, metabolism, and cardiovascular diseases : NMCD, 2012, Volume: 22, Issue:3 Topics: Age Factors; Animal Nutritional Physiological Phenomena; Animals; Body Weight; Diet, High-Fat; Energ	2012
Anti-diabetic effects of mildronate alone or in combination with metformin in obese Zucker rats. European journal of pharmacology, 2011, May-11, Volume: 658, Issue:2-3 Topics: Animals; Blood Glucose; Body Weight; Cell Nucleus; Drug Combinations; Eating; Gene Expression Regula	2011
Glucose and insulin modify thrombospondin 1 expression and secretion in primary adipocytes from diet-induced obese rats. Journal of physiology and biochemistry, 2011, Volume: 67, Issue:3 Topics: Adipocytes; Animals; Blood Glucose; Body Weight; Cell Survival; Cells, Cultured; Diet, High-Fat; Gen	2011
Lactate and the GPR81 receptor in metabolic regulation: implications for adipose tissue function and fatty acid utilisation by muscle during exercise. The British journal of nutrition, 2011, Volume: 106, Issue:9 Topics: Adipose Tissue, White; Carbohydrate Metabolism; Energy Metabolism; Exercise; Fatty Acids; Glucose; H	2011
Impaired insulin-mediated antilipolysis and lactate release in adipose tissue of upper-body obese women. Obesity (Silver Spring, Md.), 2012, Volume: 20, Issue:1 Topics: Adipose Tissue; Adult; Body Constitution; Fatty Acids, Nonesterified; Female; Glucose Clamp Techniqu	2012
Assessment of aerobic capacity during swimming exercise in ob/ob mice. Cell biochemistry and function, 2011, Volume: 29, Issue:8 Topics: Animals; Disease Models, Animal; Exercise Therapy; Humans; Lactic Acid; Male; Mice; Mice, Inbred C57	2011
Metabonomics reveals plasma metabolic changes and inflammatory marker in polycystic ovary syndrome patients. Journal of proteome research, 2012, May-04, Volume: 11, Issue:5 Topics: Adult; Amino Acids; Blood Glucose; Blood Proteins; Body Mass Index; Case-Control Studies; Citric Aci	2012
Effects of hyperoxia exposure on metabolic markers and gene expression in 3T3-L1 adipocytes. Journal of physiology and biochemistry, 2012, Volume: 68, Issue:4 Topics: 3T3-L1 Cells; Adipocytes; Animals; Biomarkers; Cell Hypoxia; Cell Survival; Chemokine CCL2; Culture	2012
Exercise as a new physiological stimulus for brown adipose tissue activity. Nutrition, metabolism, and cardiovascular diseases : NMCD, 2013, Volume: 23, Issue:6 Topics: Adipocytes; Adipose Tissue, Brown; Animals; Cell Transdifferentiation; Energy Metabolism; Forkhead T	2013
Differences in early acetaminophen hepatotoxicity between obese ob/ob and db/db mice. The Journal of pharmacology and experimental therapeutics, 2012, Volume: 342, Issue:3 Topics: 3-Hydroxybutyric Acid; Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-	2012
Parental diet-induced obesity leads to retarded early mouse embryo development and altered carbohydrate utilisation by the blastocyst. Reproduction, fertility, and development, 2012, Volume: 24, Issue:6 Topics: Adiposity; Animals; Blastocyst; Carbohydrate Metabolism; Cell Cycle; Diet, High-Fat; Disease Models,	2012
Metabolic master regulators: sharing information among multiple systems. Trends in endocrinology and metabolism: TEM, 2012, Volume: 23, Issue:12 Topics: Adipose Tissue; Diabetes Mellitus, Type 2; Female; Homeostasis; Humans; Insulin Resistance; Lactic A	2012
Determination of the maximal lactate steady state in obese Zucker rats. International journal of sports medicine, 2013, Volume: 34, Issue:3 Topics: Anaerobic Threshold; Animals; Biomarkers; Exercise Test; Female; Lactic Acid; Motor Activity; Obesit	2013
Efferent projections of neuropeptide Y-expressing neurons of the dorsomedial hypothalamus in chronic hyperphagic models. The Journal of comparative neurology, 2013, Jun-01, Volume: 521, Issue:8 Topics: Age Factors; Animals; Animals, Newborn; Biotin; Chronic Disease; Dextrans; Disease Models, Animal; E	2013
Metabolic signatures of human adipose tissue hypoxia in obesity. Diabetes, 2013, Volume: 62, Issue:5 Topics: Adult; Body Mass Index; Cell Hypoxia; Fasting; Female; Forearm; Glucose; Glycolysis; Humans; Lactic	2013
Burdock fermented by Aspergillus awamori elevates cecal Bifidobacterium, and reduces fecal deoxycholic acid and adipose tissue weight in rats fed a high-fat diet. Bioscience, biotechnology, and biochemistry, 2013, Volume: 77, Issue:1 Topics: Acetic Acid; Adipose Tissue; Animals; Arctium; Aspergillus; Bifidobacterium; Butyric Acid; Cecum; De	2013
Metabolomic profilings of urine and serum from high fat-fed rats via 1H NMR spectroscopy and pattern recognition. Applied biochemistry and biotechnology, 2013, Volume: 169, Issue:4 Topics: 3-Hydroxybutyric Acid; Animals; Choline; Citric Acid; Creatinine; Diabetes Mellitus, Type 2; Dietary	2013
Effects of obesity phenotype on coronary heart disease risk factors in response to weight loss. Obesity research, 2002, Volume: 10, Issue:8 Topics: Adult; Anthropometry; Blood Glucose; Blood Pressure; Body Composition; Cholesterol; Coronary Disease	2002
Topical therapy with tretinoin and ammonium lactate for acanthosis nigricans associated with obesity. Cutis, 2003, Volume: 71, Issue:1 Topics: Acanthosis Nigricans; Administration, Topical; Adolescent; Drug Therapy, Combination; Humans; Kerato	2003
[Metformin-associated lactic acidosis remains a serious complication of metformin therapy]. Annales francaises d'anesthesie et de reanimation, 2003, Volume: 22, Issue:5 Topics: Acidosis, Lactic; Acute Kidney Injury; Adult; Aged; Diabetes Complications; Diabetes Mellitus, Type	2003
Selective adipose tissue ablation by localized, sustained drug delivery. Plastic and reconstructive surgery, 2003, Volume: 112, Issue:1 Topics: Adipose Tissue; Administration, Topical; Animals; Apoptosis; Biodegradation, Environmental; Blood Gl	2003
Studies on obesity. II. Blood pyruvate and lactate curves in obese and normal subjects after ingestion of glucose. The Journal of clinical endocrinology and metabolism, 1956, Volume: 16, Issue:3 Topics: Blood; Eating; Glucose; Humans; Lactates; Lactic Acid; Obesity; Pyruvates; Pyruvic Acid	1956
INCORPORATION OF TRITIUM INTO HUMAN PLASMA TRIGLYCERIDES FROM GLUCOSE-1-H3 AND LACTIC ACID-2-H3. Nature, 1964, Feb-15, Volume: 201 Topics: Carbon Dioxide; Carbon Isotopes; Diabetes Mellitus; Glucose; Glycerides; Humans; Hydrogen; Lactates;	1964
CHRONIC ACIDOSIS DUE TO AN ERROR IN LACTATE AND PYRUVATE METABOLISM. REPORT OF TWO CASES. Pediatrics, 1964, Volume: 34 Topics: Acetoacetates; Acidosis; Blood; Blood Gas Analysis; Carbohydrate Metabolism; Carbohydrate Metabolism	1964
Energy restriction reduces the number of advanced aberrant crypt foci and attenuates the expression of colonic transforming growth factor beta and cyclooxygenase isoforms in Zucker obese (fa/fa) rats. Cancer research, 2003, Oct-15, Volume: 63, Issue:20 Topics: Animals; Azoxymethane; Blood Glucose; Body Weight; Caloric Restriction; Carcinogens; Colonic Neoplas	2003
Insulin secretion in monosodium glutamate (MSG) obese rats submitted to aerobic exercise training. Physiological chemistry and physics and medical NMR, 2003, Volume: 35, Issue:1 Topics: Animals; Blood Glucose; Body Weight; Fats; Female; Glucose; Glucose Tolerance Test; Insulin; Insulin	2003
Postexercise muscle triacylglycerol and glycogen metabolism in obese insulin-resistant zucker rats. Obesity research, 2004, Volume: 12, Issue:7 Topics: Animals; Blood Glucose; Dietary Carbohydrates; Eating; Fatty Acids, Nonesterified; Female; Glycogen;	2004
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Fructose transport and metabolism in adipose tissue of Zucker rats: diminished GLUT5 activity during obesity and insulin resistance. Molecular and cellular biochemistry, 2004, Volume: 261, Issue:1-2 Topics: Adipocytes; Adipose Tissue; Animals; Biological Transport; Blood Glucose; Cell Membrane; Fructose; G	2004
Obesity-prone rats have preexisting defects in their counterregulatory response to insulin-induced hypoglycemia. American journal of physiology. Regulatory, integrative and comparative physiology, 2004, Volume: 287, Issue:5 Topics: Adipose Tissue; Animals; Arcuate Nucleus of Hypothalamus; Blood Glucose; Body Composition; Catechola	2004
Impact of altered substrate utilization on cardiac function in isolated hearts from Zucker diabetic fatty rats. American journal of physiology. Heart and circulatory physiology, 2005, Volume: 288, Issue:5 Topics: Animals; Carbon Isotopes; Diabetes Mellitus, Type 2; Energy Metabolism; Fatty Acids; Glucose; In Vit	2005
beta2-adrenergic receptor polymorphisms and salbutamol-stimulated energy expenditure. The Journal of clinical endocrinology and metabolism, 2005, Volume: 90, Issue:4 Topics: Adult; Albuterol; Blood Pressure; Codon; Energy Metabolism; Fatty Acids, Nonesterified; Female; Glyc	2005
Endurance training increases lactate transport in male Zucker fa/fa rats. Biochemical and biophysical research communications, 2005, Jun-17, Volume: 331, Issue:4 Topics: Amino Acid Sequence; Animals; Biological Transport; Body Weight; Glucose Tolerance Test; Glycolysis;	2005
Substrate oxidation during exercise: impact of time interval from the last meal in obese women. International journal of obesity (2005), 2005, Volume: 29, Issue:8 Topics: Analysis of Variance; Blood Glucose; Calorimetry, Indirect; Eating; Energy Metabolism; Exercise; Exe	2005
Ischemic preconditioning improves energy state and transplantation survival in obese Zucker rat livers. Anesthesia and analgesia, 2005, Volume: 101, Issue:6 Topics: Adenosine Triphosphate; Animals; Energy Metabolism; Ischemic Preconditioning; Lactic Acid; Liver; Li	2005
Lower excess postexercise oxygen consumption and altered growth hormone and cortisol responses to exercise in obese men. The Journal of clinical endocrinology and metabolism, 2006, Volume: 91, Issue:2 Topics: Adult; Body Temperature; Exercise; Heart Rate; Human Growth Hormone; Humans; Hydrocortisone; Lactic	2006
Protection against Western diet-induced obesity and hepatic steatosis in liver fatty acid-binding protein knockout mice. Hepatology (Baltimore, Md.), 2006, Volume: 44, Issue:5 Topics: Animals; Cholesterol, Dietary; Dietary Fats; Energy Intake; Enzymes; Fatty Acid Synthases; Fatty Aci	2006
Insulin resistance and the mitochondrial link. Lessons from cultured human myotubes. Biochimica et biophysica acta, 2007, Volume: 1772, Issue:7 Topics: 2,4-Dinitrophenol; Antimycin A; Case-Control Studies; Cells, Cultured; Diabetes Mellitus, Type 2; Gl	2007
Berberine improves glucose metabolism through induction of glycolysis. American journal of physiology. Endocrinology and metabolism, 2008, Volume: 294, Issue:1 Topics: 3T3-L1 Cells; Adenosine Monophosphate; Adenosine Triphosphate; Adipocytes; AMP-Activated Protein Kin	2008
Inter-modal comparisons of acute energy expenditure during perceptually based exercise in obese adults. Journal of nutritional science and vitaminology, 2008, Volume: 54, Issue:1 Topics: Adult; Aged; Blood Pressure; Energy Metabolism; Exercise; Exercise Test; Female; Heart Rate; Humans;	2008
Effects of Intrabrachial metacholine infusion on muscle capillary recruitment and forearm glucose uptake during physiological hyperinsulinemia in obese, insulin-resistant individuals. The Journal of clinical endocrinology and metabolism, 2008, Volume: 93, Issue:7 Topics: Adult; Brachial Artery; Capillaries; Forearm; Glucose; Humans; Hyperinsulinism; Insulin; Insulin Res	2008
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The actions of dichloroacetic acid on blood glucose, liver glycogen and fatty acid synthesis in obese-hyperglycaemic (ob/ob) and lean mice. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1983, Volume: 15, Issue:5 Topics: Acetates; Adipose Tissue; Animals; Blood Glucose; Dichloroacetic Acid; Fatty Acids; Female; Hypergly	1983
Effects of an adenosine-receptor antagonist on insulin-resistance in soleus muscle from obese Zucker rats. The Biochemical journal, 1984, Aug-01, Volume: 221, Issue:3 Topics: Animals; Glycogen; Glycolysis; In Vitro Techniques; Insulin; Lactates; Lactic Acid; Male; Muscles; O	1984
Lipogenesis from U14C lactate in obese Zucker rat hepatocytes. Effect of albumin-bound oleate. Life sciences, 1984, Sep-10, Volume: 35, Issue:11 Topics: Albumins; Animals; Fatty Acids; Glycerol; Lactates; Lactic Acid; Lipids; Liver; Male; Obesity; Oleic	1984
A metabolic profile of fed and fasting genetically obese mice at 4-5 months of age. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1984, Volume: 16 Suppl 1 Topics: Alanine; Animals; Blood Glucose; Carbohydrate Metabolism; Diet; Fatty Acids, Nonesterified; Insulin	1984
Hormonal and metabolic changes in starving obese patients during exhaustive physical exercise. Journal of endocrinological investigation, 1983, Volume: 6, Issue:6 Topics: Carbohydrate Metabolism; Epinephrine; Fatty Acids; Female; Glycerol; Hormones; Humans; Hydrogen-Ion	1983
Intravenous glucose tolerance test in childhood obesity: metabolite levels and their relation to glucose utilization rate (KG). Acta paediatrica Academiae Scientiarum Hungaricae, 1982, Volume: 23, Issue:2 Topics: Blood Glucose; Body Height; Child; Cholesterol; Fasting; Fatty Acids, Nonesterified; Glucose Toleran	1982
Effect of glucagon infusion on some plasma metabolites and hormones in obese children. Acta paediatrica Academiae Scientiarum Hungaricae, 1982, Volume: 23, Issue:2 Topics: Amino Acids; Blood Glucose; Child; Cholesterol; Fatty Acids, Nonesterified; Glucagon; Glycerol; Grow	1982
Brown adipose tissue metabolism in hypothalamic-obese rats. Metabolism: clinical and experimental, 1983, Volume: 32, Issue:2 Topics: Adipose Tissue, Brown; Aging; Animals; Diet; Fatty Acids; Glucose; Hypothalamus; Lactates; Lactic Ac	1983
Effects of calcium, aluminium, magnesium and cholestyramine on hyperoxaluria in patients with jejunoileal bypass. Acta chirurgica Scandinavica, 1983, Volume: 149, Issue:1 Topics: Adult; Aluminum; Calcium; Calcium Gluconate; Cholestyramine Resin; Female; Humans; Ileum; Intestinal	1983
Preservation of glucose tolerance and insulin secretory response to repeated glucose levels by the feeding of minimal glucose during prolonged fasting. Metabolism: clinical and experimental, 1981, Volume: 30, Issue:12 Topics: Adult; Blood Glucose; Body Weight; Fasting; Fatty Acids, Nonesterified; Food; Glucagon; Glucose; Glu	1981
Peripheral insulinaemia and the glucoregulatory response to exercise in diabetic man. Current problems in clinical biochemistry, 1982, Volume: 11 Topics: Blood Glucose; Diabetes Mellitus; Humans; Insulin; Lactates; Lactic Acid; Obesity; Physical Exertion	1982
Effect of protein-supplemented fasting on metabolic and hormonal responses to epinephrine infusion in obese subjects. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1982, Volume: 14, Issue:5 Topics: Adult; Blood Glucose; Dietary Proteins; Epinephrine; Fasting; Fatty Acids, Nonesterified; Female; Gl	1982
The effect of caffeine and physical exercise on blood lactate levels of obese children. Acta paediatrica Academiae Scientiarum Hungaricae, 1982, Volume: 23, Issue:3 Topics: Adolescent; Caffeine; Child; Fatty Acids, Nonesterified; Humans; Lactates; Lactic Acid; Muscles; Obe	1982
Metabolic effects of metformin in non-insulin-dependent diabetes mellitus. The New England journal of medicine, 1995, Aug-31, Volume: 333, Issue:9 Topics: Blood Glucose; Body Composition; Diabetes Mellitus; Diabetes Mellitus, Type 2; Energy Metabolism; Fe	1995
Metabolic effects of metformin in non-insulin-dependent diabetes mellitus. The New England journal of medicine, 1995, Aug-31, Volume: 333, Issue:9 Topics: Blood Glucose; Body Composition; Diabetes Mellitus; Diabetes Mellitus, Type 2; Energy Metabolism; Fe	1995
Metabolic effects of metformin in non-insulin-dependent diabetes mellitus. The New England journal of medicine, 1995, Aug-31, Volume: 333, Issue:9 Topics: Blood Glucose; Body Composition; Diabetes Mellitus; Diabetes Mellitus, Type 2; Energy Metabolism; Fe	1995
Metabolic effects of metformin in non-insulin-dependent diabetes mellitus. The New England journal of medicine, 1995, Aug-31, Volume: 333, Issue:9 Topics: Blood Glucose; Body Composition; Diabetes Mellitus; Diabetes Mellitus, Type 2; Energy Metabolism; Fe	1995
Metabolic effects of metformin in non-insulin-dependent diabetes mellitus. The New England journal of medicine, 1995, Aug-31, Volume: 333, Issue:9 Topics: Blood Glucose; Body Composition; Diabetes Mellitus; Diabetes Mellitus, Type 2; Energy Metabolism; Fe	1995
Metabolic effects of metformin in non-insulin-dependent diabetes mellitus. The New England journal of medicine, 1995, Aug-31, Volume: 333, Issue:9 Topics: Blood Glucose; Body Composition; Diabetes Mellitus; Diabetes Mellitus, Type 2; Energy Metabolism; Fe	1995
Metabolic effects of metformin in non-insulin-dependent diabetes mellitus. The New England journal of medicine, 1995, Aug-31, Volume: 333, Issue:9 Topics: Blood Glucose; Body Composition; Diabetes Mellitus; Diabetes Mellitus, Type 2; Energy Metabolism; Fe	1995
Metabolic effects of metformin in non-insulin-dependent diabetes mellitus. The New England journal of medicine, 1995, Aug-31, Volume: 333, Issue:9 Topics: Blood Glucose; Body Composition; Diabetes Mellitus; Diabetes Mellitus, Type 2; Energy Metabolism; Fe	1995
Metabolic effects of metformin in non-insulin-dependent diabetes mellitus. The New England journal of medicine, 1995, Aug-31, Volume: 333, Issue:9 Topics: Blood Glucose; Body Composition; Diabetes Mellitus; Diabetes Mellitus, Type 2; Energy Metabolism; Fe	1995
Peripheral 3-hydroxybutyrate and food intake in a model of dietary-fat induced obesity: effect of vagotomy. Physiology & behavior, 1995, Volume: 58, Issue:1 Topics: 3-Hydroxybutyric Acid; Adipose Tissue, Brown; Animals; Appetite Regulation; Body Weight; Brain; Diet	1995
Evidence for a sustained genetic effect on fat storage capacity in cultured adipose cells from Zucker rats. The American journal of physiology, 1994, Volume: 267, Issue:3 Pt 1 Topics: Adipose Tissue; Animals; Cell Differentiation; Cells, Cultured; Dietary Fats; Genotype; Glucose; Lac	1994
Long-term effects of cafeteria diet feeding on young Wistar rats. Biochemistry and molecular biology international, 1994, Volume: 33, Issue:2 Topics: 3-Hydroxybutyric Acid; Aging; Animals; Blood Glucose; Body Weight; Diet; Female; Glycerol; Hydroxybu	1994
Glucose metabolism during the starved-to-fed transition in obese patients with NIDDM. Diabetes, 1994, Volume: 43, Issue:12 Topics: 3-Hydroxybutyric Acid; Adult; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 2; Fasting;	1994
Decreased responsiveness of basal gluconeogenesis to insulin action in hepatocytes isolated from genetically obese (fa/fa) Zucker rats. Endocrinology, 1994, Volume: 134, Issue:4 Topics: Animals; Cell Separation; Fructosediphosphates; Gluconeogenesis; Glucose; Insulin; Lactates; Lactic	1994
Body fat and sympathetic nerve activity in healthy subjects. Circulation, 1994, Volume: 89, Issue:6 Topics: Adolescent; Adult; Cardiovascular Diseases; Energy Metabolism; Female; Humans; Insulin; Lactates; La	1994
Alanine as a lipogenic precursor in isolated hepatocytes from obese Zucker rats. Cellular and molecular biology (Noisy-le-Grand, France), 1993, Volume: 39, Issue:6 Topics: Acetyl Coenzyme A; Alanine; Alanine Transaminase; Animals; Cells, Cultured; Citrates; Coumaric Acids	1993
Obese men with type IIB hyperlipidemia are insulin resistant. Arteriosclerosis and thrombosis : a journal of vascular biology, 1993, Volume: 13, Issue:10 Topics: Blood Glucose; Calorimetry, Indirect; Fatty Acids, Nonesterified; Glucose; Glucose Clamp Technique;	1993
The association among fat distribution, physical fitness, and the risk factors of cardiovascular disease in obese women. Obesity research, 1995, Volume: 3 Suppl 5 Topics: Adipose Tissue; Adult; Aged; Body Composition; Body Constitution; Cardiovascular Diseases; Cholester	1995
Carbohydrate metabolism in insulin resistance: glucose uptake and lactate production by adipose and forearm tissues in vivo before and after a mixed meal. Clinical science (London, England : 1979), 1996, Volume: 90, Issue:5 Topics: Adipose Tissue; Adult; Female; Forearm; Glucose; Humans; Insulin; Insulin Resistance; Lactates; Lact	1996
Effects of pyruvate and lactate on food intake in rat strains sensitive and resistant to dietary obesity. Physiology & behavior, 1996, Volume: 59, Issue:3 Topics: Animals; Body Weight; Diet; Diet, Fat-Restricted; Dietary Fats; Eating; Lactates; Lactic Acid; Liver	1996
Hepatic gluconeogenesis and the activity of PDH in individual tissues of GTG-obese mice following adrenalectomy. Obesity research, 1996, Volume: 4, Issue:4 Topics: Adrenalectomy; Animals; Aurothioglucose; Blood Glucose; Citrate (si)-Synthase; Fatty Acids, Nonester	1996
Metabolic and endocrine effects of interleukin-1 in obese, diabetic Zucker fa/fa rats. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 1996, Volume: 104, Issue:4 Topics: Animals; Blood Glucose; Cholesterol; Corticosterone; Diabetes Mellitus; Diabetes Mellitus, Type 2; D	1996
Carbohydrate handling in exercising muscle of obese Zucker rats. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 1997, Volume: 21, Issue:3 Topics: Animals; Carbohydrate Metabolism; Female; Glucose; Glycogen; Glycolysis; Lactic Acid; Lipids; Muscle	1997
Lactate-bicarbonate interrelationship during exercise and recovery in lean and obese Zucker rats. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 1997, Volume: 21, Issue:5 Topics: Animals; Arteries; Bicarbonates; Carbon Dioxide; Female; Hydrogen-Ion Concentration; Lactic Acid; Ob	1997
Decreased white fat cell thermogenesis in obese individuals. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 1997, Volume: 21, Issue:6 Topics: Adipocytes; Body Temperature Regulation; Calorimetry; Cells, Cultured; Fatty Acids, Nonesterified; F	1997
Evidence for altered sensitivity of the nitric oxide/cGMP signalling cascade in insulin-resistant skeletal muscle. The Biochemical journal, 1998, Jan-01, Volume: 329 ( Pt 1) Topics: Animals; Cell Fractionation; Cyclic GMP; Female; Glucose; Glycogen; Insulin; Insulin Resistance; Lac	1998
The metabolic effects of pokeweed mitogen in mice. Metabolism: clinical and experimental, 1998, Volume: 47, Issue:1 Topics: Animals; B-Lymphocytes; Blood Glucose; Cell Line; Cytokines; Deoxyglucose; Diabetes Mellitus, Type 2	1998
Hind leg heat balance in obese Zucker rats during exercise. Pflugers Archiv : European journal of physiology, 1998, Volume: 435, Issue:4 Topics: Animals; Blood Gas Analysis; Body Temperature Regulation; Female; Hindlimb; Lactic Acid; Muscle, Ske	1998
Lactate production from glucose and response to insulin in perifused adipocytes from mesenteric and epididymal regions of lean and obese rats. Obesity research, 1998, Volume: 6, Issue:1 Topics: Adipocytes; Aging; Animals; Body Weight; Cell Size; Epididymis; Fasting; Glucose; Insulin; Lactic Ac	1998
Response of insulin, glucagon, lactate, and nonesterified fatty acids to glucose in visceral obesity with and without NIDDM: relationship to hypertension. Molecular genetics and metabolism, 1998, Volume: 63, Issue:3 Topics: Adult; Blood Pressure; Diabetes Mellitus, Type 2; Fatty Acids, Nonesterified; Female; Glucagon; Gluc	1998
Hepatic glycogen and lactate handling in dietary obese rats. Annals of nutrition & metabolism, 1998, Volume: 42, Issue:3 Topics: Animals; Diet; Female; Glucose; Lactic Acid; Liver; Liver Circulation; Liver Glycogen; Obesity; Orga	1998
Lactate production in pancreatic islets. Diabetes, 1998, Volume: 47, Issue:8 Topics: Animals; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Glucose; Insulin; I	1998
Glucose production, utilization, and cycling in response to moderate exercise in obese subjects with type 2 diabetes and mild hyperglycemia. Diabetes, 1998, Volume: 47, Issue:11 Topics: Adult; Alanine; Blood Glucose; C-Peptide; Diabetes Mellitus; Diabetes Mellitus, Type 2; Exercise; Fe	1998
Acute effects of exercise on circulating leptin in lean and genetically obese fa/fa rats. Biochemical and biophysical research communications, 1999, Feb-24, Volume: 255, Issue:3 Topics: Adipose Tissue; Animals; Blood Glucose; Fatty Acids, Nonesterified; Female; Glycerol; Insulin; Lacti	1999
Substrate utilization during submaximal exercise in obese and normal-weight women. European journal of applied physiology and occupational physiology, 1999, Volume: 80, Issue:3 Topics: Adolescent; Adult; Analysis of Variance; Basal Metabolism; Body Mass Index; Body Weight; Energy Meta	1999
Metformin inhibits catecholamine-stimulated lipolysis in obese, hyperinsulinemic, hypertensive subjects in subcutaneous adipose tissue: an in situ microdialysis study. Diabetic medicine : a journal of the British Diabetic Association, 1999, Volume: 16, Issue:12 Topics: Adipose Tissue; Adult; Body Mass Index; Electric Impedance; Epinephrine; Female; Glycerol; Humans; H	1999
Effect of sibutramine on glucose metabolism in genetically obese (fa/fa) Zucker rats. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 2000, Volume: 24 Suppl 2 Topics: Animals; Appetite Depressants; Blood Glucose; Body Weight; Cyclobutanes; Eating; Glucose Clamp Techn	2000
Plasma acyl-estrone levels are altered in obese women. Endocrine research, 2000, Volume: 26, Issue:3 Topics: Acylation; Adipose Tissue; Adult; Aspartate Aminotransferases; Blood Glucose; Body Composition; Body	2000
Zinc-induced hyperleptinemia relates to the amelioration of sucrose-induced obesity with zinc repletion. Obesity research, 2000, Volume: 8, Issue:7 Topics: Animals; Blood Glucose; Diet; Dietary Sucrose; Insulin; Lactic Acid; Leptin; Male; Mice; Obesity; Tr	2000
Diurnal metabolic profiles after 14 d of an ad libitum high-starch, high-sucrose, or high-fat diet in normal-weight never-obese and postobese women. The American journal of clinical nutrition, 2001, Volume: 73, Issue:2 Topics: Adult; Area Under Curve; Blood Glucose; Body Weight; Circadian Rhythm; Cross-Over Studies; Dietary F	2001
In situ metabolic and hemodynamic response to dexfenfluramine in white adipose tissue of rats. Annals of nutrition & metabolism, 2001, Volume: 45, Issue:1 Topics: Adipose Tissue; Adrenergic beta-Agonists; Animals; Dexfenfluramine; Glycolysis; Isoproterenol; Lacti	2001
Relationships between personality disorders and anthropometry, hormones and metabolism in women. Journal of endocrinological investigation, 2001, Volume: 24, Issue:3 Topics: Adrenocorticotropic Hormone; Adult; Affective Symptoms; Anthropometry; Anxiety; Blood Glucose; Body	2001
Lactate and glycerol release from adipose tissue in lean, obese, and diabetic women from South Africa. The Journal of clinical endocrinology and metabolism, 2001, Volume: 86, Issue:7 Topics: Adipose Tissue; Adult; Black People; Body Composition; C-Peptide; Diabetes Mellitus; Diabetes Mellit	2001
Glucose tolerance and insulin action in monosodium glutamate (MSG) obese exercise-trained rats. Physiological chemistry and physics and medical NMR, 2001, Volume: 33, Issue:1 Topics: Adipose Tissue; Animals; Blood Glucose; Body Composition; Female; Food Additives; Glucose; Glucose T	2001
Hypocaloric diet reduces exercise-induced alpha 2-adrenergic antilipolytic effect and alpha 2-adrenergic receptor mRNA levels in adipose tissue of obese women. The Journal of clinical endocrinology and metabolism, 2002, Volume: 87, Issue:3 Topics: Abdomen; Adipose Tissue; Adult; Diet, Reducing; Energy Intake; Exercise; Extracellular Space; Fatty	2002
Cardiac carbohydrate metabolism in Zucker diabetic fatty rats. Cardiovascular research, 2002, Volume: 55, Issue:1 Topics: Animals; Carbohydrate Metabolism; Carbon Isotopes; Diabetes Mellitus, Type 2; Fatty Acids; Glucose;	2002
Effect of very low calorie diet on body composition and exercise response in sedentary women. European journal of applied physiology and occupational physiology, 1992, Volume: 65, Issue:5 Topics: Adult; Blood Pressure; Body Composition; Energy Intake; Exercise; Female; Heart Rate; Humans; Lactat	1992
Insulin resistance in obesity is associated with elevated basal lactate levels and diminished lactate appearance following intravenous glucose and insulin. Metabolism: clinical and experimental, 1992, Volume: 41, Issue:1 Topics: Adult; Female; Glucose Tolerance Test; Humans; Injections, Intravenous; Insulin; Insulin Resistance;	1992
Postprandial thermogenesis at rest and postexercise before and after physical training in lean, obese, and mildly diabetic men. Metabolism: clinical and experimental, 1992, Volume: 41, Issue:8 Topics: Adult; Analysis of Variance; Blood Glucose; Body Temperature Regulation; Diabetes Mellitus; Diabetes	1992
Relationships of obesity indices to serum insulin and lipoproteins in relatives of black patients with noninsulin-dependent diabetes mellitus (NIDDM). International journal of obesity, 1991, Volume: 15, Issue:7 Topics: Adipose Tissue; Administration, Oral; Adult; Anthropometry; Black People; Blood Glucose; Body Mass I	1991
Mechanism of metformin action in obese and lean noninsulin-dependent diabetic subjects. The Journal of clinical endocrinology and metabolism, 1991, Volume: 73, Issue:6 Topics: Blood Glucose; Body Weight; Diabetes Mellitus; Diabetes Mellitus, Type 2; Fasting; Female; Glucose;	1991
Lactate generation following glucose ingestion: relation to obesity, carbohydrate tolerance and insulin sensitivity. International journal of obesity, 1990, Volume: 14, Issue:10 Topics: Adult; Blood Glucose; Body Mass Index; Diabetes Mellitus; Diabetes Mellitus, Type 2; Dietary Carbohy	1990
Properties of the Na+-K+ pump in human red cells with increased number of pump sites. The Journal of clinical investigation, 1987, Volume: 80, Issue:1 Topics: Adenosine Triphosphate; Cations, Monovalent; Erythrocytes; Humans; Ion Channels; Kinetics; Lactates;	1987
Metabolic response to short term starvation in non-pregnant and late pregnant cafeteria-obese rats. Archives internationales de physiologie et de biochimie, 1989, Volume: 97, Issue:1 Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Blood Glucose; Female; Fetal Blood; Glycerol; Hydroxy	1989
Glutamine metabolism in isolated incubated adipocytes of the rat. The Biochemical journal, 1988, Feb-01, Volume: 249, Issue:3 Topics: Adipose Tissue; Alanine; Ammonia; Animals; Glucose; Glutamates; Glutamic Acid; Glutaminase; Glutamin	1988
Effect of a novel thermogenic beta-adrenoceptor agonist (BRL 26830) on insulin resistance in soleus muscle from obese Zucker rats. Biochemical and biophysical research communications, 1985, Apr-30, Volume: 128, Issue:2 Topics: Animals; Blood Glucose; Ethanolamines; Glycogen; Insulin Resistance; Lactates; Lactic Acid; Male; Mu	1985
Characterization of new oral antidiabetic agent CS-045. Studies in KK and ob/ob mice and Zucker fatty rats. Diabetes, 1988, Volume: 37, Issue:11 Topics: Adipose Tissue; Animals; Benzopyrans; Blood Glucose; Chromans; Deoxyglucose; Diabetes Mellitus, Expe	1988
Increased parathyroid hormone as a consequence of changed complex binding of plasma calcium in morbid obesity. Metabolism: clinical and experimental, 1986, Volume: 35, Issue:2 Topics: Adult; Arachidonic Acid; Arachidonic Acids; Calcium; Citrates; Citric Acid; Fatty Acids, Nonesterifi	1986
Glucose uptake in human adipose tissue. Metabolism: clinical and experimental, 1987, Volume: 36, Issue:12 Topics: Abdomen; Adipose Tissue; Adult; Blood Glucose; C-Peptide; Female; Glucose; Humans; Insulin; Lactates	1987
Clinical application of lactate threshold to the treatment of obesity. Journal of human ergology, 1987, Volume: 16, Issue:2 Topics: Adult; Anaerobiosis; Combined Modality Therapy; Diet, Reducing; Energy Metabolism; Exercise; Female;	1987
Different types of postinsulin receptor defects contribute to insulin resistance in hearts of obese Zucker rats. Endocrinology, 1986, Volume: 119, Issue:3 Topics: Adenine Nucleotides; Animals; Energy Metabolism; Epoxy Compounds; Glucose; Insulin Resistance; Lacta	1986
The fate of 14C derived from radioactively labelled dietary precursors in young rats of the Zucker strain (Fa/- and fa/fa). The Biochemical journal, 1986, Apr-15, Volume: 235, Issue:2 Topics: Animals; Carbon Radioisotopes; Glucose; Lactates; Lactic Acid; Leucine; Obesity; Palmitic Acid; Palm	1986
Exercise and diet reduce muscle insulin resistance in obese Zucker rat. The American journal of physiology, 1986, Volume: 251, Issue:3 Pt 1 Topics: Animals; Dietary Carbohydrates; Glucose; Glycogen; Hexokinase; Insulin Resistance; Lactates; Lactic	1986
Food-induced thermogenesis in obese children. European journal of pediatrics, 1985, Volume: 144, Issue:1 Topics: Adolescent; Blood Glucose; Body Temperature Regulation; Child; Energy Metabolism; Fatty Acids, Nones	1985
Effects of fructose feeding on lipid parameters in obese and lean, diabetic and nondiabetic Zucker rats. The Journal of nutrition, 1985, Volume: 115, Issue:10 Topics: Animals; Body Weight; Cholesterol; Diabetes Mellitus; Diabetes Mellitus, Experimental; Dietary Carbo	1985
Comparison of glucose-induced changes in electrical activity, insulin release, lactate output and potassium permeability between normal and ob/ob mouse islets: effects of cooling. The Journal of endocrinology, 1985, Volume: 107, Issue:2 Topics: Animals; Cell Membrane Permeability; Cold Temperature; Female; Glucose; Insulin; Insulin Secretion;	1985
Hyperuricemia and hypertriglyceridemia: metabolic basis for the association. Metabolism: clinical and experimental, 1985, Volume: 34, Issue:8 Topics: Adult; Aged; Creatinine; Dietary Carbohydrates; Fat Emulsions, Intravenous; Female; Glucose; Gout; H	1985

lactic acid and Obesity