lactic acid has been researched along with Neurodegenerative Diseases in 19 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Neurodegenerative Diseases: Hereditary and sporadic conditions which are characterized by progressive nervous system dysfunction. These disorders are often associated with atrophy of the affected central or peripheral nervous system structures.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Increasing evidence from pathological and biochemical investigations suggests that mitochondrial metabolic impairment and oxidative stress play a crucial role in the pathogenesis of mitochondrial diseases, such as mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome, and various neurodegenerative disorders." | 5.12 | Molecular imaging for mitochondrial metabolism and oxidative stress in mitochondrial diseases and neurodegenerative disorders. ( Ikawa, M; Okazawa, H; Yoneda, M, 2021) |
| " Drug-loaded nanosystems, particularly nanoparticles (NPs), were successfully used to address numerous drug glitches, such as efficacy, bioavailability and safety." | 2.82 | Brain drug delivery and neurodegenerative diseases: Polymeric PLGA-based nanoparticles as a forefront platform. ( Barreiro, S; Borges, F; Fernandes, C; Pinto, M; Remião, F; Silva, R; Silva, V, 2022) |
| "Lip cyanosis is an important initial symptom in LS." | 1.72 | Lip cyanosis as the first symptom of Leigh syndrome associated with mitochondrial complex I deficiency due to a compound heterozygous NDUFS1 mutation: A case report. ( Cao, L; Feng, J; Huang, W; Men, L; Sun, R; Xu, J; Xu, M; Zhao, X, 2022) |
| "PEHO syndrome is a rare symptom complex of severe progressive encephalopathy, edema, hypsarrhythmia, and optic atrophy." | 1.33 | Serial MR imaging, diffusion tensor imaging, and MR spectroscopic findings in a child with progressive encephalopathy, edema, hypsarrhythmia, and optic atrophy (PEHO) syndrome. ( Boltshauser, E; Huisman, TA; Klein, A; Straube, T; Werner, B, 2006) |
| " Therefore, dosing can be changed from the conventional twice a day to once every 2 weeks." | 1.32 | Microspheres containing insulin-like growth factor I for treatment of chronic neurodegeneration. ( Carrascosa, C; Carro, E; Espejo, L; Lopez-Lopez, C; Torrado, JJ; Torrado, S; Torres-Aleman, I, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (21.05) | 29.6817 |
| 2010's | 7 (36.84) | 24.3611 |
| 2020's | 8 (42.11) | 2.80 |
| Authors | Studies |
|---|---|
| Pinto, M | 1 |
| Silva, V | 1 |
| Barreiro, S | 1 |
| Silva, R | 1 |
| Remião, F | 1 |
| Borges, F | 1 |
| Fernandes, C | 1 |
| Bøgh, N | 1 |
| Laustsen, C | 1 |
| Hansen, ESS | 1 |
| Tankisi, H | 1 |
| Bertelsen, LB | 1 |
| Blicher, JU | 1 |
| Men, L | 1 |
| Feng, J | 1 |
| Huang, W | 1 |
| Xu, M | 1 |
| Zhao, X | 1 |
| Sun, R | 1 |
| Xu, J | 1 |
| Cao, L | 1 |
| Bazi Alahri, M | 1 |
| Jibril Ibrahim, A | 1 |
| Barani, M | 1 |
| Arkaban, H | 1 |
| Shadman, SM | 1 |
| Salarpour, S | 1 |
| Zarrintaj, P | 1 |
| Jaberi, J | 1 |
| Turki Jalil, A | 1 |
| Wu, A | 1 |
| Lee, D | 1 |
| Xiong, WC | 1 |
| Tian, Q | 1 |
| Li, J | 1 |
| Wu, B | 1 |
| Wang, J | 1 |
| Xiao, Q | 1 |
| Tian, N | 1 |
| Yi, L | 1 |
| Luo, M | 1 |
| Li, Z | 1 |
| Pang, Y | 1 |
| Shi, X | 1 |
| Dong, Z | 1 |
| Ma, K | 1 |
| Ding, X | 1 |
| Song, Q | 1 |
| Han, Z | 1 |
| Yao, H | 1 |
| Ding, J | 1 |
| Hu, G | 1 |
| Ikawa, M | 1 |
| Okazawa, H | 1 |
| Yoneda, M | 1 |
| Nakano, F | 1 |
| Sakushima, K | 1 |
| Umeki, R | 1 |
| Yabe, I | 1 |
| Endoh, A | 1 |
| Sasaki, H | 1 |
| Vazquez, A | 1 |
| Doolaanea, AA | 1 |
| Mansor, N' | 1 |
| Mohd Nor, NH | 1 |
| Mohamed, F | 1 |
| Fornaguera, C | 1 |
| Feiner-Gracia, N | 1 |
| Calderó, G | 1 |
| García-Celma, MJ | 1 |
| Solans, C | 1 |
| Jesse, S | 1 |
| Brettschneider, J | 1 |
| Süssmuth, SD | 1 |
| Landwehrmeyer, BG | 1 |
| von Arnim, CA | 1 |
| Ludolph, AC | 1 |
| Tumani, H | 1 |
| Otto, M | 1 |
| Tosi, G | 1 |
| Fano, RA | 1 |
| Bondioli, L | 1 |
| Badiali, L | 1 |
| Benassi, R | 1 |
| Rivasi, F | 1 |
| Ruozi, B | 1 |
| Forni, F | 1 |
| Vandelli, MA | 1 |
| Chertov, AO | 1 |
| Holzhausen, L | 1 |
| Kuok, IT | 1 |
| Couron, D | 1 |
| Parker, E | 1 |
| Linton, JD | 1 |
| Sadilek, M | 1 |
| Sweet, IR | 1 |
| Hurley, JB | 1 |
| Gambini, A | 1 |
| Falini, A | 1 |
| Moiola, L | 1 |
| Comi, G | 1 |
| Scotti, G | 1 |
| Carrascosa, C | 1 |
| Torres-Aleman, I | 1 |
| Lopez-Lopez, C | 1 |
| Carro, E | 1 |
| Espejo, L | 1 |
| Torrado, S | 1 |
| Torrado, JJ | 1 |
| Huisman, TA | 1 |
| Klein, A | 1 |
| Werner, B | 1 |
| Straube, T | 1 |
| Boltshauser, E | 1 |
| Shin, CY | 1 |
| Choi, JW | 1 |
| Ryu, JR | 1 |
| Ko, KH | 1 |
| Choi, JJ | 1 |
| Kim, HS | 2 |
| Lee, JC | 1 |
| Lee, SJ | 1 |
| Kim, HC | 1 |
| Kim, WK | 1 |
4 reviews available for lactic acid and Neurodegenerative Diseases
| Article | Year |
|---|---|
Brain drug delivery and neurodegenerative diseases: Polymeric PLGA-based nanoparticles as a forefront platform.
Topics: Brain; Drug Delivery Systems; Glycols; Humans; Lactic Acid; Nanoparticles; Neurodegenerative Disease | 2022 |
Management of Brain Cancer and Neurodegenerative Disorders with Polymer-Based Nanoparticles as a Biocompatible Platform.
Topics: Blood-Brain Barrier; Brain Neoplasms; Drug Carriers; Drug Delivery Systems; Humans; Lactic Acid; Nan | 2023 |
Lactate Metabolism, Signaling, and Function in Brain Development, Synaptic Plasticity, Angiogenesis, and Neurodegenerative Diseases.
Topics: Brain; Humans; Lactic Acid; Neurodegenerative Diseases; Neuronal Plasticity; Signal Transduction | 2023 |
Molecular imaging for mitochondrial metabolism and oxidative stress in mitochondrial diseases and neurodegenerative disorders.
Topics: Acidosis, Lactic; Brain Diseases; Electron Transport; Fatty Acids; Glucose; Humans; Lactic Acid; Mag | 2021 |
15 other studies available for lactic acid and Neurodegenerative Diseases
| Article | Year |
|---|---|
Imaging Neurodegenerative Metabolism in Amyotrophic Lateral Sclerosis with Hyperpolarized [1-
Topics: Amyotrophic Lateral Sclerosis; Bicarbonates; Humans; Lactic Acid; Magnetic Resonance Imaging; Neurod | 2022 |
Lip cyanosis as the first symptom of Leigh syndrome associated with mitochondrial complex I deficiency due to a compound heterozygous NDUFS1 mutation: A case report.
Topics: Child; Cyanosis; Disease Progression; Electron Transport Complex I; Humans; Infant; Infant, Newborn; | 2022 |
Hypoxia-sensing VGLL4 promotes LDHA-driven lactate production to ameliorate neuronal dysfunction in a cellular model relevant to Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Hypoxia; Lactic A | 2023 |
Lactate enhances Arc/arg3.1 expression through hydroxycarboxylic acid receptor 1-β-arrestin2 pathway in astrocytes.
Topics: Animals; Astrocytes; beta-Arrestin 2; Calcium Signaling; Cells, Cultured; Cytoskeletal Proteins; Lac | 2020 |
Effects of age and glucose levels on lactate levels in cerebrospinal fluid examination of neurodegenerative diseases.
Topics: Adult; Aged; Aged, 80 and over; Aging; Cerebrospinal Fluid Proteins; Female; Glucose; Humans; Lactic | 2017 |
Metabolic states following accumulation of intracellular aggregates: implications for neurodegenerative diseases.
Topics: Ammonia; Cells; Computer Simulation; Glucose; Humans; Intracellular Space; Lactic Acid; Metabolic Fl | 2013 |
Cellular uptake of Nigella sativa oil-PLGA microparticle by PC-12 cell line.
Topics: Animals; Hexoses; Lactic Acid; Neurodegenerative Diseases; Octoxynol; PC12 Cells; Plant Oils; Polygl | 2014 |
Galantamine-loaded PLGA nanoparticles, from nano-emulsion templating, as novel advanced drug delivery systems to treat neurodegenerative diseases.
Topics: Cholinesterase Inhibitors; Drug Carriers; Emulsions; Galantamine; HeLa Cells; Humans; Lactic Acid; N | 2015 |
Summary of cerebrospinal fluid routine parameters in neurodegenerative diseases.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Blood-Brain Barrier; Enzyme-Linked Immunosorbent Assay; | 2011 |
Investigation on mechanisms of glycopeptide nanoparticles for drug delivery across the blood-brain barrier.
Topics: Animals; Blood-Brain Barrier; Drug Delivery Systems; Glycopeptides; Lactic Acid; Loperamide; Male; N | 2011 |
Roles of glucose in photoreceptor survival.
Topics: Acetylglucosamine; Adenosine Triphosphate; Animals; Autophagy; Cell Death; Cell Survival; Gas Chroma | 2011 |
Marchiafava-Bignami disease: longitudinal MR imaging and MR spectroscopy study.
Topics: Alcohol-Related Disorders; Atrophy; Choline; Corpus Callosum; Creatine; Demyelinating Diseases; Huma | 2003 |
Microspheres containing insulin-like growth factor I for treatment of chronic neurodegeneration.
Topics: Animals; Ataxia; Coated Materials, Biocompatible; Delayed-Action Preparations; Female; Insulin-Like | 2004 |
Serial MR imaging, diffusion tensor imaging, and MR spectroscopic findings in a child with progressive encephalopathy, edema, hypsarrhythmia, and optic atrophy (PEHO) syndrome.
Topics: Aspartic Acid; Atrophy; Brain Diseases; Brain Edema; Cerebellum; Child; Choline; Creatine; Diffusion | 2006 |
Glucose deprivation decreases nitric oxide production via NADPH depletion in immunostimulated rat primary astrocytes.
Topics: Adjuvants, Immunologic; Animals; Animals, Newborn; Astrocytes; Biopterins; Cell Death; Cells, Cultur | 2002 |