Page last updated: 2024-10-17

lactic acid and Nervous System Disorders

lactic acid has been researched along with Nervous System Disorders in 42 studies

Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.

Research Excerpts

ExcerptRelevanceReference
"We evaluated the ability of four biomarkers (C-Reactive protein (CRP), lactate, mid-regional proadrenomedullin (MR-proADM) and procalcitonin (PCT)) to detect each kind of organ failure considered in the SOFA in 213 patients with infection, sepsis or septic shock, by using multivariate regression analysis and calculation of the area under the receiver operating curve (AUROC)."3.96MR- proADM to detect specific types of organ failure in infection. ( Aldecoa, C; Almansa, R; Andaluz-Ojeda, D; Andrés, C; Bermejo-Martin, JF; Calvo, D; Cicuendez, R; Esteban-Velasco, MC; Martín, S; Martin-Fernandez, M; Muñoz-Bellvís, L; Nogales, L; Ríos-Llorente, A; Sanchez-Barrado, E; Vaquero-Roncero, LM, 2020)
"The effect of lactic acidosis on neurological development in the first year of life."3.88Neurological impairments in hypoxic neonates and lactate levels. ( Jovandaric, MZ; Milenkovic, SJ, 2018)
"23 studies involving 6720 cardiac arrest (CA) patients were included."2.58Blood Lactate or Lactate Clearance: Which Is Robust to Predict the Neurological Outcomes after Cardiac Arrest? A Systematic Review and Meta-Analysis. ( Liu, CF; Liu, LJ; Zhang, Z; Zhou, BC; Zhu, JJ, 2018)
"Moderate to severe neonatal encephalopathy in asphyxiated term infants is associated with a high risk of cerebral palsy (especially quadriplegic or dyskinetic type) and/or cognitive disorders."2.44[Definition of intrapartum asphyxia and effects on outcome]. ( Zupan Simunek, V, 2008)
"CSF LA in the groups with viral meningitis was not different compared to groups with non-infectious CNS diseases and chronic meningitis."1.35Quantitation of cerebrospinal fluid lactic acid in infectious and non-infectious neurological diseases. ( Berto, DB; Buczenko, GM; de Almeida, SM; de Goes Fontes, K; Faria, FL; Nogueira, MB; Raboni, SM; Vidal, LR, 2009)
"Rabbits whose cerebral vasospasm were 50% or over 50% (n=7) and NSS is lesser than 3 were termed as groups 2, and rabbits whose cerebral vasospasm were 50% or above 50% (n=7) and NSS is greater than 3 were termed groups 3."1.34Lactate contents from cerebrospinal fluid in experimental subarachnoid hemorrhage, well correlate with vasospasm: ongoing and neurologic status. ( Ak, A; Cengiz, SL; Karaköse, S; Ustün, ME, 2007)
"After 4 min of cardiac arrest, followed by 3 min of basic life support CPR, 17 animals were randomly assigned to receive, every 5 min, either a combination of vasopressin and epinephrine (vasopressin [IU/kg]/epinephrine [ micro g/kg]: 0."1.32Survival with full neurologic recovery after prolonged cardiopulmonary resuscitation with a combination of vasopressin and epinephrine in pigs. ( Klima, GCDN; Krismer, AC; Lindner, KH; Mayr, VD; Pechlaner, S; Rheinberger, K; Stadlbauer, KH; Voelckel, WG; Wagner-Berger, HG; Wenzel, V, 2003)
"Lactate at 48 hours after cardiac arrest is an independent predictor of mortality and unfavorable neurologic outcome."1.32Serial lactate determinations for prediction of outcome after cardiac arrest. ( Havel, C; Holzer, M; Kliegel, A; Laggner, AN; Losert, H; Sterz, F; Zeiner, A, 2004)
"122 had definite RCD, 38 neurological disorders other than RCD."1.31Diagnostic yield of the lactate stress test in 160 patients with suspected respiratory chain disorder. ( Finsterer, J; Milvay, E; Obermann, I, 2000)
"Biotin deficiency associated with total parenteral nutrition is an emerging clinical problem; criteria for diagnosis and dosage for treatment are unclear."1.27Biotin deficiency complicating parenteral alimentation: diagnosis, metabolic repercussions, and treatment. ( Baker, H; Baswell, DL; Holman, RT; Mock, DM; Sweetman, L, 1985)

Research

Studies (42)

TimeframeStudies, this research(%)All Research%
pre-19904 (9.52)18.7374
1990's4 (9.52)18.2507
2000's9 (21.43)29.6817
2010's17 (40.48)24.3611
2020's8 (19.05)2.80

Authors

AuthorsStudies
Rawat, A1
Morrison, BM1
Jarius, S1
Pache, F1
Körtvelyessy, P1
Jelčić, I1
Stettner, M1
Franciotta, D1
Keller, E1
Neumann, B1
Ringelstein, M1
Senel, M1
Regeniter, A1
Kalantzis, R1
Willms, JF1
Berthele, A1
Busch, M1
Capobianco, M1
Eisele, A1
Reichen, I1
Dersch, R1
Rauer, S1
Sandner, K1
Ayzenberg, I1
Gross, CC1
Hegen, H1
Khalil, M1
Kleiter, I1
Lenhard, T1
Haas, J1
Aktas, O1
Angstwurm, K1
Kleinschnitz, C1
Lewerenz, J1
Tumani, H1
Paul, F1
Stangel, M1
Ruprecht, K1
Wildemann, B1
Sood, N1
Sangari, A1
Goyal, A1
Conway, JAS1
Guo, W1
Ma, L1
Tuerhong, T1
Li, X1
Liu, B1
Xie, Z1
Yu, X1
Oh, TK1
Song, IA1
Bae, HJ1
Jeon, YT1
Romano, D1
Deiner, S1
Cherukuri, A1
Boateng, B1
Shrivastava, R1
Mocco, J1
Hadjipanayis, C1
Yong, R1
Kellner, C1
Yaeger, K1
Lin, HM2
Brallier, J1
Andrés, C1
Andaluz-Ojeda, D1
Cicuendez, R1
Nogales, L1
Martín, S1
Martin-Fernandez, M1
Almansa, R1
Calvo, D1
Esteban-Velasco, MC1
Vaquero-Roncero, LM1
Ríos-Llorente, A1
Sanchez-Barrado, E1
Muñoz-Bellvís, L1
Aldecoa, C1
Bermejo-Martin, JF1
Martín-Rodríguez, F2
López-Izquierdo, R2
Medina-Lozano, E1
Ortega Rabbione, G1
Del Pozo Vegas, C2
Carbajosa Rodríguez, V1
Castro Villamor, MÁ2
Sánchez-Soberon, I1
Sanz-García, A1
Xu, J1
Jakher, Y1
Ahrens-Nicklas, RC1
Juaristi, I1
García-Martín, ML1
Rodrigues, TB1
Satrústegui, J1
Llorente-Folch, I1
Pardo, B1
Horvat, A1
Vardjan, N1
Zorec, R1
Adler, C1
Paul, C1
Hinkelbein, J1
Michels, G1
Pfister, R1
Krings, A1
Lechleuthner, A1
Stangl, R1
Jovandaric, MZ1
Milenkovic, SJ1
Zhou, BC1
Zhang, Z1
Zhu, JJ1
Liu, LJ1
Liu, CF1
Mangas, IM1
Del Brío Ibáñez, P1
Delgado Benito, JF1
Martín Conty, JL1
Manzanares, JÁ1
Mayo-Iscar, A1
Das, BP1
Sharma, M1
Bansal, S1
Philip, M1
Umamaheswara Rao, GS1
Kaji, AH1
Hanif, AM1
Bosson, N1
Ostermayer, D1
Niemann, JT1
Arveladze, GA1
Geladze, NM1
Sanikidze, TB1
Khachapuridze, NS1
Bakhtadze, SZ1
Brallier, JW1
Dalal, PJ1
McCormick, PJ1
Deiner, SG1
Horosh, M1
Feldman, H1
Yablonovich, A1
Firer, MA1
Abookasis, D1
Hifumi, T1
Kawakita, K1
Yoda, T1
Okazaki, T1
Kuroda, Y1
de Almeida, SM1
Faria, FL1
de Goes Fontes, K1
Buczenko, GM1
Berto, DB1
Raboni, SM1
Vidal, LR1
Nogueira, MB1
Wang, Q1
van Hoecke, M1
Tang, XN1
Lee, H1
Zheng, Z1
Swanson, RA1
Yenari, MA1
Bhargava, D1
Al-Tamimi, Y1
Quinn, A1
Ross, S1
Chen, H1
Spagnoli, F1
Burris, M1
Rolland, WB1
Fajilan, A1
Dou, H1
Tang, J1
Zhang, JH1
Alves, RL1
Aragão e Silva, AL1
Kraychete, NC1
Campos, GO1
Martins, Mde J1
Módolo, NS1
Mackie, AS1
Alton, GY1
Dinu, IA1
Joffe, AR1
Roth, SJ1
Newburger, JW1
Robertson, CM1
Stadlbauer, KH1
Wagner-Berger, HG1
Wenzel, V1
Voelckel, WG1
Krismer, AC1
Klima, GCDN1
Rheinberger, K1
Pechlaner, S1
Mayr, VD1
Lindner, KH1
Kliegel, A1
Losert, H1
Sterz, F1
Holzer, M1
Zeiner, A1
Havel, C1
Laggner, AN1
Finsterer, J2
Milvay, E2
Cengiz, SL1
Ak, A1
Ustün, ME1
Karaköse, S1
Zupan Simunek, V1
Jaeger, A1
Kopferschmitt, J1
Sauder, P1
Benmatti, A1
Mantz, JM1
Pach, J1
Kamenczak, A1
Panas, M1
Anderson, YS1
Curtis, NJ1
Hobbs, JA1
Thompson, CH1
Winearls, CG1
Radda, GK1
Clarke, K1
Altmann, P1
Carlini, SM1
Beyers, N1
Schoeman, JF1
Nel, ED1
Truter, EJ1
Donald, PR1
Obermann, I1
Liu, XL1
Nozari, A1
Basu, S1
Ronquist, G1
Rubertsson, S1
Wiklund, L1
Russell, JL1
Kushner, MG1
Beitman, BD1
Bartels, KM1
Stansbie, D1
Wallace, SJ1
Marsac, C1
Vaagenes, P1
Kjekshus, J1
Sivertsen, E1
Semb, G1
Mock, DM1
Baswell, DL1
Baker, H1
Holman, RT1
Sweetman, L1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Evaluation of the Heart's Respiratory Quotient as Predictive Value After Extra-hospital[NCT04211207]40 participants (Actual)Observational2020-01-27Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

7 reviews available for lactic acid and Nervous System Disorders

ArticleYear
Metabolic Transporters in the Peripheral Nerve-What, Where, and Why?
    Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2021, Volume: 18, Issue:4

    Topics: Animals; Glucose; Lactic Acid; Monocarboxylic Acid Transporters; Nervous System Diseases; Peripheral

2021
Predictors of survival for pediatric extracorporeal cardiopulmonary resuscitation: A systematic review and meta-analysis.
    Medicine, 2022, Sep-30, Volume: 101, Issue:39

    Topics: Cardiopulmonary Resuscitation; Child; Creatinine; Humans; Lactic Acid; Nervous System Diseases; Oxyg

2022
Brain Branched-Chain Amino Acids in Maple Syrup Urine Disease: Implications for Neurological Disorders.
    International journal of molecular sciences, 2020, Oct-11, Volume: 21, Issue:20

    Topics: Amino Acids, Branched-Chain; Aspartic Acid; Brain; Central Nervous System; Disease Susceptibility; G

2020
Targeting Astrocytes for Treating Neurological Disorders: Carbon Monoxide and Noradrenaline-Induced Increase in Lactate.
    Current pharmaceutical design, 2017, Volume: 23, Issue:33

    Topics: Animals; Astrocytes; Carbon Monoxide; Drug Delivery Systems; Humans; Lactic Acid; Nervous System Dis

2017
Blood Lactate or Lactate Clearance: Which Is Robust to Predict the Neurological Outcomes after Cardiac Arrest? A Systematic Review and Meta-Analysis.
    BioMed research international, 2018, Volume: 2018

    Topics: Biomarkers; Heart Arrest; Humans; Lactic Acid; Metabolic Clearance Rate; Nervous System Diseases

2018
[Definition of intrapartum asphyxia and effects on outcome].
    Journal de gynecologie, obstetrique et biologie de la reproduction, 2008, Volume: 37 Suppl 1

    Topics: Acidosis; Apgar Score; Biomarkers; Brain Diseases; Cerebral Palsy; Female; Fetal Blood; Fetal Hypoxi

2008
Disorders of the pyruvate dehydrogenase complex.
    Journal of inherited metabolic disease, 1986, Volume: 9, Issue:2

    Topics: Acetyl Coenzyme A; Acetyltransferases; Acidosis; Brain; Carbon Dioxide; Child; Child, Preschool; Coe

1986

Other Studies

35 other studies available for lactic acid and Nervous System Disorders

ArticleYear
Cerebrospinal fluid findings in COVID-19: a multicenter study of 150 lumbar punctures in 127 patients.
    Journal of neuroinflammation, 2022, Jan-20, Volume: 19, Issue:1

    Topics: Adult; Blood-Brain Barrier; Cerebrospinal Fluid Proteins; COVID-19; Cytokines; Europe; Female; Human

2022
[Correlation between four limbs perfusion index and lactic acid in patients with severe neurological diseases].
    Zhonghua wei zhong bing ji jiu yi xue, 2023, Volume: 35, Issue:5

    Topics: Adult; Aged; Area Under Curve; Female; Humans; Lactic Acid; Lower Extremity; Male; Microcirculation;

2023
Serum lactate level upon admission to the neuro-intensive care unit and 90-day mortality: A retrospective study.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2019, Volume: 70

    Topics: Adult; Aged; Area Under Curve; Critical Illness; Female; Hospital Mortality; Humans; Intensive Care

2019
Clinical impact of intraoperative hyperlactatemia during craniotomy.
    PloS one, 2019, Volume: 14, Issue:10

    Topics: Cohort Studies; Craniotomy; Female; Humans; Hyperlactatemia; Intraoperative Complications; Lactic Ac

2019
MR- proADM to detect specific types of organ failure in infection.
    European journal of clinical investigation, 2020, Volume: 50, Issue:6

    Topics: Adrenomedullin; Aged; Aged, 80 and over; Area Under Curve; Blood Coagulation Disorders; C-Reactive P

2020
Accuracy of prehospital point-of-care lactate in early in-hospital mortality.
    European journal of clinical investigation, 2020, Volume: 50, Issue:12

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Ambulances; Area Under Curve; Cardiovascular Diseases; E

2020
ARALAR/AGC1 deficiency, a neurodevelopmental disorder with severe impairment of neuronal mitochondrial respiration, does not produce a primary increase in brain lactate.
    Journal of neurochemistry, 2017, Volume: 142, Issue:1

    Topics: Aggrecans; Amino Acid Transport Systems, Acidic; Animals; Antiporters; Astrocytes; Brain Chemistry;

2017
[Which patients benefit from transport with ongoing cardiopulmonary resuscitation? : Retrospective analysis of 70 patients with refractory preclinical cardiac arrest].
    Der Anaesthesist, 2018, Volume: 67, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Cardiopulmonary Resuscitation; Female; Germany; Glasgow Outcome Scal

2018
Neurological impairments in hypoxic neonates and lactate levels.
    Neurological research, 2018, Volume: 40, Issue:10

    Topics: Acidosis; Age Factors; Blood Gas Analysis; Female; Gestational Age; Humans; Hypoxia; Infant, Newborn

2018
Prognostic value of lactate in prehospital care as a predictor of early mortality.
    The American journal of emergency medicine, 2019, Volume: 37, Issue:9

    Topics: Aged; Aged, 80 and over; Area Under Curve; Cardiovascular Diseases; Critical Illness; Emergency Medi

2019
Prognostic Value of Tissue Oxygen Monitoring and Regional Cerebral Oxygen Saturation Monitoring and Their Correlation in Neurological Patients with Sepsis: A Preliminary, Prospective, Observational Study.
    Journal of neurosurgical anesthesiology, 2020, Volume: 32, Issue:1

    Topics: Adult; Aged; APACHE; Female; Glasgow Coma Scale; Glasgow Outcome Scale; Hospital Mortality; Humans;

2020
Predictors of neurologic outcome in patients resuscitated from out-of-hospital cardiac arrest using classification and regression tree analysis.
    The American journal of cardiology, 2014, Oct-01, Volume: 114, Issue:7

    Topics: Aged; California; Cardiopulmonary Resuscitation; Dose-Response Relationship, Drug; Epinephrine; Fema

2014
[The role of lactate acidosis in the development and treatment of various neurologic syndromes in children and adolescents].
    Georgian medical news, 2015, Issue:239

    Topics: Acidosis; Adolescent; Child; Child, Preschool; Electroencephalography; Energy Metabolism; Epilepsy;

2015
Elevated Intraoperative Serum Lactate During Craniotomy Is Associated With New Neurological Deficit and Longer Length of Stay.
    Journal of neurosurgical anesthesiology, 2017, Volume: 29, Issue:4

    Topics: Acute Kidney Injury; Adult; Aged; Cerebrovascular Circulation; Cohort Studies; Craniotomy; Female; H

2017
Broadband Infrared Spectroscopy for Non-Contact Measurement of Neurological Disease Biomarkers in Cerebrospinal Fluid.
    Applied spectroscopy, 2017, Volume: 71, Issue:3

    Topics: Albumins; Biomarkers; Humans; Lactic Acid; Nervous System Diseases; Spectrophotometry, Infrared; Spi

2017
Association of brain metabolites with blood lactate and glucose levels with respect to neurological outcomes after out-of-hospital cardiac arrest: A preliminary microdialysis study.
    Resuscitation, 2017, Volume: 110

    Topics: Adult; Aged; Biomarkers; Blood Glucose; Brain; Cerebrovascular Circulation; Female; Humans; Hypother

2017
Quantitation of cerebrospinal fluid lactic acid in infectious and non-infectious neurological diseases.
    Clinical chemistry and laboratory medicine, 2009, Volume: 47, Issue:6

    Topics: Adult; Biomarkers; Cerebrospinal Fluid; Diagnosis, Differential; Female; Humans; Lactic Acid; Leukoc

2009
Pyruvate protects against experimental stroke via an anti-inflammatory mechanism.
    Neurobiology of disease, 2009, Volume: 36, Issue:1

    Topics: Animals; Body Weight; Cell Count; Disease Models, Animal; Ectodysplasins; Encephalitis; Infarction,

2009
New modalities to assess efficacy of triple-h therapy: early experience.
    Acta neurochirurgica. Supplement, 2011, Volume: 110, Issue:Pt 2

    Topics: Blood Pressure; Blood Volume; Cerebrovascular Circulation; Hemodilution; Humans; Hypoxia-Ischemia, B

2011
Nanoerythropoietin is 10-times more effective than regular erythropoietin in neuroprotection in a neonatal rat model of hypoxia and ischemia.
    Stroke, 2012, Volume: 43, Issue:3

    Topics: Animals; Animals, Newborn; Behavior, Animal; Brain Ischemia; Cerebral Infarction; Erythropoietin; Ex

2012
Intraoperative lactate levels and postoperative complications of pediatric cardiac surgery.
    Paediatric anaesthesia, 2012, Volume: 22, Issue:8

    Topics: Adolescent; Blood Gas Analysis; Blood Volume; Cardiac Surgical Procedures; Cardiopulmonary Bypass; C

2012
Clinical outcome score predicts the need for neurodevelopmental intervention after infant heart surgery.
    The Journal of thoracic and cardiovascular surgery, 2013, Volume: 145, Issue:5

    Topics: Biomarkers; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cardiotonic Agents; Chi-Square Dist

2013
Survival with full neurologic recovery after prolonged cardiopulmonary resuscitation with a combination of vasopressin and epinephrine in pigs.
    Anesthesia and analgesia, 2003, Volume: 96, Issue:6

    Topics: Animals; Blood Gas Analysis; Blood Pressure; Body Weight; Cardiopulmonary Resuscitation; Drug Combin

2003
Serial lactate determinations for prediction of outcome after cardiac arrest.
    Medicine, 2004, Volume: 83, Issue:5

    Topics: Age Factors; Aged; Biomarkers; Electrocardiography; Emergency Medical Services; Female; Follow-Up St

2004
Stress lactate in mitochondrial myopathy under constant, unadjusted workload.
    European journal of neurology, 2004, Volume: 11, Issue:12

    Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Cohort Studies; Ergometry; Exercise Test; F

2004
Lactate contents from cerebrospinal fluid in experimental subarachnoid hemorrhage, well correlate with vasospasm: ongoing and neurologic status.
    Journal of neurosurgical anesthesiology, 2007, Volume: 19, Issue:3

    Topics: Animals; Basilar Artery; Biomarkers; Cisterna Magna; Disease Models, Animal; Lactic Acid; Male; Nerv

2007
[Acute nadoxolol poisoning. A multicentric study of 35 cases].
    Toxicological European research. Recherche europeenne en toxicologie, 1982, Volume: 4, Issue:3

    Topics: Acute Disease; Adolescent; Adult; Aged; Cardiovascular Diseases; Child, Preschool; Dopamine; Electro

1982
The frequency of toxic methemoglobinemias in people living in the vicinity of refuse dumps in Barycz.
    Przeglad lekarski, 1996, Volume: 53, Issue:4

    Topics: Adolescent; Adult; Aged; Air Pollutants; Environmental Monitoring; Epidemiological Monitoring; Femal

1996
High serum D-lactate in patients on continuous ambulatory peritoneal dialysis.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1997, Volume: 12, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Case-Control Studies; Dialysis Solutions; Female; Humans; Kidney Fai

1997
Adenylate kinase activity in the cerebrospinal fluid of children with tuberculous meningitis and its relationship to neurological outcome.
    Scandinavian journal of infectious diseases, 1997, Volume: 29, Issue:3

    Topics: Adenylate Kinase; Adolescent; Antitubercular Agents; Child; Child, Preschool; Drug Therapy, Combinat

1997
Diagnostic yield of the lactate stress test in 160 patients with suspected respiratory chain disorder.
    Metabolic brain disease, 2000, Volume: 15, Issue:3

    Topics: Adolescent; Adult; Aged; Electron Transport; Exercise; Exercise Test; Female; Humans; Lactic Acid; M

2000
Neurological outcome after experimental cardiopulmonary resuscitation: a result of delayed and potentially treatable neuronal injury?
    Acta anaesthesiologica Scandinavica, 2002, Volume: 46, Issue:5

    Topics: Angioplasty, Balloon, Coronary; Animals; Cardiopulmonary Resuscitation; Cerebrovascular Circulation;

2002
Nonfearful panic disorder in neurology patients validated by lactate challenge.
    The American journal of psychiatry, 1991, Volume: 148, Issue:3

    Topics: Adult; Anxiety Disorders; Fear; Female; Follow-Up Studies; Humans; Infusions, Intravenous; Lactates;

1991
Temporal pattern of enzyme changes in cerebrospinal fluid in patients with neurologic complications after open heart surgery.
    Critical care medicine, 1987, Volume: 15, Issue:8

    Topics: Aged; Aspartate Aminotransferases; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Creatine Kin

1987
Biotin deficiency complicating parenteral alimentation: diagnosis, metabolic repercussions, and treatment.
    The Journal of pediatrics, 1985, Volume: 106, Issue:5

    Topics: Alopecia; Biotin; Citrates; Diagnosis, Differential; Erythema; Fatty Acids, Essential; Female; Glyci

1985