lactic acid has been researched along with Nerve Degeneration in 33 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study has examined the anticonvulsant and neuroprotective effect of group II metabotropic glutamate receptor (mGluR) agonist (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate (2R,4R-APDC) in the model of seizures induced in immature 12-day-old rats by bilateral intracerebroventricular infusion of dl-homocysteic acid (DL-HCA, 600 nmol/side)." | 7.73 | Seizures induced in immature rats by homocysteic acid and the associated brain damage are prevented by group II metabotropic glutamate receptor agonist (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate. ( Druga, R; Folbergrová, J; Haugvicová, R; Kubová, H; Mares, P; Otáhal, J, 2005) |
| "The present study was undertaken to investigate the effects of the alpha2 adrenergic agonist, clonidine, on the near complete cerebral ischemia (NCFI) evoked release of glutamate and aspartate from normo- and hyperglycemic rodent brain tissue using microdialysis tissue techniques." | 7.73 | The effect of clonidine on cell survival, glutamate, and aspartate release in normo- and hyperglycemic rats after near complete forebrain ischemia. ( Jellish, WS; Kindel, G; Murdoch, J; White, FA; Zhang, X, 2005) |
| "The correlation between seizure-induced hypermetabolism and subsequent neuronal damage was studied in 10-day-old (P10), 21-day-old (P21), and adult rats subjected to lithium-pilocarpine status epilepticus (SE)." | 7.70 | Correlation between hypermetabolism and neuronal damage during status epilepticus induced by lithium and pilocarpine in immature and adult rats. ( Boyet, S; Dubé, C; Fernandes, MJ; Marescaux, C; Nehlig, A, 1999) |
| "In vivo models of cerebral ischemia pose a conceptual challenge when compared to in vitro models." | 5.31 | Preischemic hyperglycemia-aggravated damage: evidence that lactate utilization is beneficial and glucose-induced corticosterone release is detrimental. ( Miller, JJ; Payne, RS; Schurr, A; Tseng, MT, 2001) |
| "The present study has examined the anticonvulsant and neuroprotective effect of group II metabotropic glutamate receptor (mGluR) agonist (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate (2R,4R-APDC) in the model of seizures induced in immature 12-day-old rats by bilateral intracerebroventricular infusion of dl-homocysteic acid (DL-HCA, 600 nmol/side)." | 3.73 | Seizures induced in immature rats by homocysteic acid and the associated brain damage are prevented by group II metabotropic glutamate receptor agonist (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate. ( Druga, R; Folbergrová, J; Haugvicová, R; Kubová, H; Mares, P; Otáhal, J, 2005) |
| "The present study was undertaken to investigate the effects of the alpha2 adrenergic agonist, clonidine, on the near complete cerebral ischemia (NCFI) evoked release of glutamate and aspartate from normo- and hyperglycemic rodent brain tissue using microdialysis tissue techniques." | 3.73 | The effect of clonidine on cell survival, glutamate, and aspartate release in normo- and hyperglycemic rats after near complete forebrain ischemia. ( Jellish, WS; Kindel, G; Murdoch, J; White, FA; Zhang, X, 2005) |
| " Strongly elevated concentrations of myo-inositol in conjunction with normal or increased choline-containing compounds in all regions investigated point to astrocytosis and demyelination." | 3.72 | Cerebral proton magnetic resonance spectroscopy in infantile Alexander disease. ( Brockmann, K; Dechent, P; Frahm, J; Hanefeld, F; Haupt, M; Meins, M; Sperner, J; Stephani, U, 2003) |
| " To test the role of lactate as an aerobic energy substrate postischemia in vivo, we employed the cardiac-arrest-induced transient global cerebral ischemia (TGI) rat model and the monocarboxylate transporter inhibitor alpha-cyano-4-hydroxycinnamate (4-CIN)." | 3.71 | Blockade of lactate transport exacerbates delayed neuronal damage in a rat model of cerebral ischemia. ( Miller, JJ; Payne, RS; Rigor, BM; Schurr, A; Tseng, MT, 2001) |
| "The correlation between seizure-induced hypermetabolism and subsequent neuronal damage was studied in 10-day-old (P10), 21-day-old (P21), and adult rats subjected to lithium-pilocarpine status epilepticus (SE)." | 3.70 | Correlation between hypermetabolism and neuronal damage during status epilepticus induced by lithium and pilocarpine in immature and adult rats. ( Boyet, S; Dubé, C; Fernandes, MJ; Marescaux, C; Nehlig, A, 1999) |
| "Amyotrophic lateral sclerosis (ALS; Lou Gehrig's disease) is a progressive debilitating neurodegenerative disease with no cure." | 2.48 | Lactate dyscrasia: a novel explanation for amyotrophic lateral sclerosis. ( Atwood, CS; Vadakkadath Meethal, S, 2012) |
| "In vivo models of cerebral ischemia pose a conceptual challenge when compared to in vitro models." | 1.31 | Preischemic hyperglycemia-aggravated damage: evidence that lactate utilization is beneficial and glucose-induced corticosterone release is detrimental. ( Miller, JJ; Payne, RS; Schurr, A; Tseng, MT, 2001) |
| "The mean occlusion time until cardiac arrest was 14." | 1.31 | Reduced postnatal cerebral glucose metabolism measured by PET after asphyxia in near term fetal lambs. ( Hellström-Westas, L; Hernandez-Andrade, E; Ley, D; Lingman, G; Marsal, K; Ohlsson, T; Oskarsson, G; Pesonen, E; Sandell, A; Strand, SE; Thorngren-Jerneck, K; Werner, O, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.03) | 18.7374 |
| 1990's | 5 (15.15) | 18.2507 |
| 2000's | 21 (63.64) | 29.6817 |
| 2010's | 6 (18.18) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aridas, JD | 1 |
| Yawno, T | 1 |
| Sutherland, AE | 1 |
| Nitsos, I | 1 |
| Ditchfield, M | 1 |
| Wong, FY | 1 |
| Fahey, MC | 1 |
| Malhotra, A | 1 |
| Wallace, EM | 1 |
| Jenkin, G | 1 |
| Miller, SL | 1 |
| Huang, WC | 1 |
| Lai, HY | 1 |
| Kuo, LW | 1 |
| Liao, CH | 1 |
| Chang, PH | 1 |
| Liu, TC | 1 |
| Chen, SY | 1 |
| Chen, YY | 1 |
| Bourdenx, M | 1 |
| Daniel, J | 1 |
| Genin, E | 1 |
| Soria, FN | 1 |
| Blanchard-Desce, M | 1 |
| Bezard, E | 1 |
| Dehay, B | 1 |
| Muñoz Maniega, S | 1 |
| Cvoro, V | 1 |
| Chappell, FM | 1 |
| Armitage, PA | 1 |
| Marshall, I | 1 |
| Bastin, ME | 1 |
| Wardlaw, JM | 1 |
| Loepke, AW | 1 |
| Istaphanous, GK | 1 |
| McAuliffe, JJ | 1 |
| Miles, L | 1 |
| Hughes, EA | 1 |
| McCann, JC | 1 |
| Harlow, KE | 1 |
| Kurth, CD | 1 |
| Williams, MT | 1 |
| Vorhees, CV | 1 |
| Danzer, SC | 1 |
| Lagrue, E | 1 |
| Abert, B | 1 |
| Nadal, L | 1 |
| Tabone, L | 1 |
| Bodard, S | 1 |
| Medja, F | 1 |
| Lombes, A | 1 |
| Chalon, S | 1 |
| Castelnau, P | 1 |
| Yamada, A | 1 |
| Yamamoto, K | 1 |
| Imamoto, N | 1 |
| Momosaki, S | 1 |
| Hosoi, R | 1 |
| Yamaguchi, M | 1 |
| Inoue, O | 1 |
| Zimmermann, R | 1 |
| Beck, G | 1 |
| Knispel, S | 1 |
| Maler, JM | 1 |
| Weih, M | 1 |
| Wiltfang, J | 1 |
| Kornhuber, J | 1 |
| Lewczuk, P | 1 |
| Vadakkadath Meethal, S | 1 |
| Atwood, CS | 1 |
| Lee, Y | 1 |
| Morrison, BM | 1 |
| Li, Y | 1 |
| Lengacher, S | 1 |
| Farah, MH | 1 |
| Hoffman, PN | 1 |
| Liu, Y | 1 |
| Tsingalia, A | 1 |
| Jin, L | 1 |
| Zhang, PW | 1 |
| Pellerin, L | 1 |
| Magistretti, PJ | 1 |
| Rothstein, JD | 1 |
| Brockmann, K | 1 |
| Dechent, P | 1 |
| Meins, M | 1 |
| Haupt, M | 1 |
| Sperner, J | 1 |
| Stephani, U | 1 |
| Frahm, J | 1 |
| Hanefeld, F | 1 |
| Ramonet, D | 1 |
| Rodríguez, MJ | 1 |
| Fredriksson, K | 1 |
| Bernal, F | 1 |
| Mahy, N | 1 |
| Folbergrová, J | 1 |
| Druga, R | 1 |
| Otáhal, J | 1 |
| Haugvicová, R | 1 |
| Mares, P | 1 |
| Kubová, H | 1 |
| Jellish, WS | 1 |
| Murdoch, J | 1 |
| Kindel, G | 1 |
| Zhang, X | 1 |
| White, FA | 1 |
| Prins, ML | 1 |
| Fujima, LS | 1 |
| Hovda, DA | 1 |
| Salci, K | 1 |
| Nilsson, P | 1 |
| Goiny, M | 1 |
| Contant, C | 1 |
| Piper, I | 1 |
| Enblad, P | 1 |
| Casey, PA | 1 |
| McKenna, MC | 1 |
| Fiskum, G | 1 |
| Saraswati, M | 1 |
| Robertson, CL | 1 |
| Zijlmans, JC | 1 |
| de Koster, A | 1 |
| van 't Hof, MA | 1 |
| Thijssen, HO | 1 |
| Horstink, MW | 1 |
| Heerschap, A | 1 |
| Maysinger, D | 1 |
| Filipovic-Grcic, J | 1 |
| Cuello, AC | 1 |
| Tedeschi, G | 1 |
| Bertolino, A | 1 |
| Massaquoi, SG | 1 |
| Campbell, G | 1 |
| Patronas, NJ | 1 |
| Bonavita, S | 1 |
| Barnett, AS | 1 |
| Alger, JR | 1 |
| Hallett, M | 1 |
| Jenkins, BG | 1 |
| Brouillet, E | 1 |
| Chen, YC | 1 |
| Storey, E | 1 |
| Schulz, JB | 1 |
| Kirschner, P | 1 |
| Beal, MF | 1 |
| Rosen, BR | 1 |
| Fernandes, MJ | 1 |
| Dubé, C | 1 |
| Boyet, S | 1 |
| Marescaux, C | 1 |
| Nehlig, A | 1 |
| Moy, LY | 1 |
| Zeevalk, GD | 1 |
| Sonsalla, PK | 1 |
| Yamagata, K | 1 |
| Tagami, M | 1 |
| Ikeda, K | 1 |
| Noguchi, T | 1 |
| Yamori, Y | 1 |
| Nara, Y | 1 |
| Simone, IL | 1 |
| Tortorella, C | 1 |
| Federico, F | 1 |
| Liguori, M | 1 |
| Lucivero, V | 1 |
| Giannini, P | 1 |
| Carrara, D | 1 |
| Bellacosa, A | 1 |
| Livrea, P | 1 |
| Schurr, A | 2 |
| Payne, RS | 2 |
| Miller, JJ | 2 |
| Tseng, MT | 2 |
| Rigor, BM | 1 |
| Mendelowitsch, A | 1 |
| Ritz, MF | 1 |
| Ros, J | 2 |
| Langemann, H | 1 |
| Gratzl, O | 1 |
| Pearl, PL | 1 |
| Krasnewich, D | 1 |
| Pecinska, N | 1 |
| Alessandri, B | 2 |
| Landolt, H | 1 |
| Fillenz, M | 1 |
| Thorngren-Jerneck, K | 1 |
| Ley, D | 1 |
| Hellström-Westas, L | 1 |
| Hernandez-Andrade, E | 1 |
| Lingman, G | 1 |
| Ohlsson, T | 1 |
| Oskarsson, G | 1 |
| Pesonen, E | 1 |
| Sandell, A | 1 |
| Strand, SE | 1 |
| Werner, O | 1 |
| Marsal, K | 1 |
| Rice, AC | 1 |
| Zsoldos, R | 1 |
| Chen, T | 1 |
| Wilson, MS | 1 |
| Hamm, RJ | 1 |
| Bullock, MR | 1 |
| Kraig, RP | 1 |
1 review available for lactic acid and Nerve Degeneration
| Article | Year |
|---|---|
Lactate dyscrasia: a novel explanation for amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Humans; Lactic Acid; Mitochondrial Diseases; Nerve Degenerat | 2012 |
32 other studies available for lactic acid and Nerve Degeneration
| Article | Year |
|---|---|
Detecting brain injury in neonatal hypoxic ischemic encephalopathy: closing the gap between experimental and clinical research.
Topics: Analysis of Variance; Animals; Animals, Newborn; Blood Pressure; Brain Injuries; Disease Models, Ani | 2014 |
Multifunctional 3D Patternable Drug-Embedded Nanocarrier-Based Interfaces to Enhance Signal Recording and Reduce Neuron Degeneration in Neural Implantation.
Topics: Animals; Cell Survival; Drug Carriers; Elastic Modulus; Electrophysiological Phenomena; Humans; Hydr | 2015 |
Nanoparticles restore lysosomal acidification defects: Implications for Parkinson and other lysosomal-related diseases.
Topics: 1-Methyl-4-phenylpyridinium; Acids; Alkalies; Animals; Cell Death; Dopaminergic Neurons; Humans; Hyd | 2016 |
Changes in NAA and lactate following ischemic stroke: a serial MR spectroscopic imaging study.
Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Biomarkers; Brain; Brain Ischemia; Brain Mapping; Cel | 2008 |
The effects of neonatal isoflurane exposure in mice on brain cell viability, adult behavior, learning, and memory.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Blood Glucose; Brai | 2009 |
MPTP intoxication in mice: a useful model of Leigh syndrome to study mitochondrial diseases in childhood.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Basal Ganglia; Basal Ganglia Diseases; Diseas | 2009 |
Lactate is an alternative energy fuel to glucose in neurons under anesthesia.
Topics: Anesthetics, General; Animals; Autoradiography; Brain; Brain Chemistry; Carbon Radioisotopes; Cell D | 2009 |
Intrathecal IgG synthesis in patients with alterations in the neurochemical dementia diagnostics.
Topics: Albumins; Amyloid beta-Peptides; Biomarkers; Brain; Dementia; Female; Humans; Immunoglobulin G; Lact | 2010 |
Oligodendroglia metabolically support axons and contribute to neurodegeneration.
Topics: Amyotrophic Lateral Sclerosis; Animals; Axons; Cell Line; Cell Survival; Disease Models, Animal; Dow | 2012 |
Cerebral proton magnetic resonance spectroscopy in infantile Alexander disease.
Topics: Alexander Disease; Aspartic Acid; Brain; Child; Child, Preschool; Demyelinating Diseases; Disease Pr | 2003 |
In vivo neuroprotective adaptation of the glutamate/glutamine cycle to neuronal death.
Topics: Animals; Apoptosis; Brain; Brain Injuries; Cell Death; Cell Survival; Denervation; Disease Models, A | 2004 |
Seizures induced in immature rats by homocysteic acid and the associated brain damage are prevented by group II metabotropic glutamate receptor agonist (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate.
Topics: Amino Acids; Animals; Animals, Newborn; Anticonvulsants; Behavior, Animal; Brain; Brain Chemistry; B | 2005 |
The effect of clonidine on cell survival, glutamate, and aspartate release in normo- and hyperglycemic rats after near complete forebrain ischemia.
Topics: Adrenergic alpha-Agonists; Animals; Aspartic Acid; Blood Glucose; Blood Pressure; Brain Chemistry; B | 2005 |
Age-dependent reduction of cortical contusion volume by ketones after traumatic brain injury.
Topics: Age Factors; Aging; Animals; Brain Injuries; Cerebral Cortex; Disease Models, Animal; Energy Metabol | 2005 |
Low intracranial compliance increases the impact of intracranial volume insults to the traumatized brain: a microdialysis study in a traumatic brain injury rodent model.
Topics: Animals; Biomarkers; Brain; Brain Chemistry; Brain Edema; Brain Injuries; Cell Membrane; Cerebral He | 2006 |
Early and sustained alterations in cerebral metabolism after traumatic brain injury in immature rats.
Topics: Aging; Alanine; Animals; Animals, Newborn; Aspartic Acid; Brain; Brain Injuries; Cell Respiration; C | 2008 |
Proton magnetic resonance spectroscopy in suspected vascular ischemic parkinsonism.
Topics: Aged; Aspartic Acid; Brain; Brain Ischemia; Brain Mapping; Energy Metabolism; Female; Humans; Intrac | 1994 |
Effects of coencapsulated NGF and GM1 in rats with cortical lesions.
Topics: Animals; Basal Ganglia; Cerebral Cortex; Choline O-Acetyltransferase; Drug Compounding; Drug Implant | 1993 |
Proton magnetic resonance spectroscopic imaging in patients with cerebellar degeneration.
Topics: Adult; Aged; Aspartic Acid; Atrophy; Cerebellar Diseases; Cerebellum; Choline; Creatine; Humans; Lac | 1996 |
Non-invasive neurochemical analysis of focal excitotoxic lesions in models of neurodegenerative illness using spectroscopic imaging.
Topics: Aging; Animals; Aspartic Acid; Electron Transport Complex II; Energy Metabolism; Huntington Disease; | 1996 |
Correlation between hypermetabolism and neuronal damage during status epilepticus induced by lithium and pilocarpine in immature and adult rats.
Topics: Aging; Animals; Animals, Newborn; Behavior, Animal; Brain; Glucose; Lactic Acid; Lithium; Male; Nerv | 1999 |
Role for dopamine in malonate-induced damage in vivo in striatum and in vitro in mesencephalic cultures.
Topics: 2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-; 3,4-Dihydrox | 2000 |
Reduced production of lactate during hypoxia and reoxygenation in astrocytes isolated from stroke-prone spontaneously hypertensive rats.
Topics: Animals; Astrocytes; Carrier Proteins; Cell Death; Cells, Cultured; Fetus; Hypoxia, Brain; L-Lactate | 2000 |
Axonal damage in multiple sclerosis plaques: a combined magnetic resonance imaging and 1H-magnetic resonance spectroscopy study.
Topics: Adolescent; Adult; Aspartic Acid; Axons; Brain; Choline; Creatine; Female; Humans; Lactic Acid; Magn | 2001 |
Blockade of lactate transport exacerbates delayed neuronal damage in a rat model of cerebral ischemia.
Topics: Animals; Blood-Brain Barrier; Brain Ischemia; Carrier Proteins; Coumaric Acids; Energy Metabolism; H | 2001 |
17beta-Estradiol reduces cortical lesion size in the glutamate excitotoxicity model by enhancing extracellular lactate: a new neuroprotective pathway.
Topics: Animals; Brain Injuries; Cerebral Cortex; Cerebral Infarction; Disease Models, Animal; Estradiol; Ex | 2001 |
Neurologic course of congenital disorders of glycosylation.
Topics: Aspartic Acid; Brain; Brain Diseases, Metabolic, Inborn; Child; Child, Preschool; Congenital Disorde | 2001 |
Lactate reduces glutamate-induced neurotoxicity in rat cortex.
Topics: Animals; Brain Injuries; Cerebral Cortex; Drug Interactions; Extracellular Space; Glucose; Glutamic | 2001 |
Preischemic hyperglycemia-aggravated damage: evidence that lactate utilization is beneficial and glucose-induced corticosterone release is detrimental.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Animals; Blood Glucose; Brain Ischemia; Corticostero | 2001 |
Reduced postnatal cerebral glucose metabolism measured by PET after asphyxia in near term fetal lambs.
Topics: Acidosis; Animals; Animals, Newborn; Asphyxia Neonatorum; Blood Pressure; Cerebral Cortex; Cerebrova | 2001 |
Lactate administration attenuates cognitive deficits following traumatic brain injury.
Topics: Animals; Brain Chemistry; Brain Injuries; Cell Death; Cognition Disorders; Energy Metabolism; Hippoc | 2002 |
Acid-induced injury in elasmobranch brain.
Topics: Animals; Cerebellum; Electric Fish; Female; Hydrogen-Ion Concentration; Lactates; Lactic Acid; Male; | 1988 |