lactic acid has been researched along with Neoplasm Metastasis in 53 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Neoplasm Metastasis: The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In order to enhance the biological activity of α-mangostin, we formulated mangostin-encapsulated PLGA nanoparticles (Mang-NPs) and examined the molecular mechanisms by which they inhibit human and KC mice (Pdx(Cre);LSL-Kras(G12D)) pancreatic CSC characteristics in vitro, and pancreatic carcinogenesis in KPC (Pdx(Cre);LSLKras(G12D);LSL-Trp53(R172H)) mice." | 7.83 | α-Mangostin-encapsulated PLGA nanoparticles inhibit pancreatic carcinogenesis by targeting cancer stem cells in human, and transgenic (Kras(G12D), and Kras(G12D)/tp53R270H) mice. ( Shankar, S; Shrivastava, A; Srivastava, RK; Verma, RK; Yu, W, 2016) |
| "69 patients with nonmetastatic colorectal cancer (non-mCRC) and 57 with metastatic CRC (mCRC) were enrolled to evaluate the prognostic value of serum albumin (ALB), serum lactate (SLA), and lactate dehydrogenase (LDH) in patients with metastatic CRC." | 6.87 | Prognostic Significance of Serum Lactic Acid, Lactate Dehydrogenase, and Albumin Levels in Patients with Metastatic Colorectal Cancer. ( Dai, J; Peng, J; Wang, W; Wei, Y; Xia, L; Xu, H; Zhou, F, 2018) |
| "Silver nanoparticles were entrapped inside the functionalized nanoparticles (Ag-PNP-CTX), to allow detection and quantification of the cellular uptake by confocal microscopy, both in vitro and in vivo." | 5.43 | A Combined Approach Employing Chlorotoxin-Nanovectors and Low Dose Radiation To Reach Infiltrating Tumor Niches in Glioblastoma. ( Corradini, I; Franchini, MC; Locatelli, E; Matteoli, M; Monaco, I; Passoni, L; Rasile, M; Rodighiero, S; Tamborini, M, 2016) |
| "The melanoma cell metastasis to lungs was prevented by intravenous co-injection of B16BL6 melanoma cells with 1." | 5.33 | The effect of poly (aspartic acid-co-lactic acid) nanospheres on the lung metastasis of B16BL6 melanoma cells by intravenous administration. ( Hara, K; Huang, CC; Kawashima, Y; Mimura, H; Miwa, N; Tsujimoto, H, 2006) |
| " In order to enhance the biological activity of α-mangostin, we formulated mangostin-encapsulated PLGA nanoparticles (Mang-NPs) and examined the molecular mechanisms by which they inhibit human and KC mice (Pdx(Cre);LSL-Kras(G12D)) pancreatic CSC characteristics in vitro, and pancreatic carcinogenesis in KPC (Pdx(Cre);LSLKras(G12D);LSL-Trp53(R172H)) mice." | 3.83 | α-Mangostin-encapsulated PLGA nanoparticles inhibit pancreatic carcinogenesis by targeting cancer stem cells in human, and transgenic (Kras(G12D), and Kras(G12D)/tp53R270H) mice. ( Shankar, S; Shrivastava, A; Srivastava, RK; Verma, RK; Yu, W, 2016) |
| "Sorafenib, a multikinase inhibitor, has been used as an anti-angiogenic agent against highly vascular hepatocellular carcinoma (HCC) - yet associated with only moderate therapeutic effect and the high incidence of HCC recurrence." | 3.81 | CXCR4-targeted lipid-coated PLGA nanoparticles deliver sorafenib and overcome acquired drug resistance in liver cancer. ( Chang, CC; Chen, Y; Chiang, WH; Gao, DY; Lin, TsT; Liu, JY; Liu, YC; Sung, YC, 2015) |
| " MRS (two patients with medulloblastoma and one with a SPNET), showed elevated choline, decreased N-acetyl aspartate, and a small taurine peak in all three patients." | 3.74 | Paediatric PNET: pre-surgical MRI features. ( Chawla, A; Emmanuel, JV; Lim, CC; Lou, J; Seow, WT; Teo, HE, 2007) |
| "69 patients with nonmetastatic colorectal cancer (non-mCRC) and 57 with metastatic CRC (mCRC) were enrolled to evaluate the prognostic value of serum albumin (ALB), serum lactate (SLA), and lactate dehydrogenase (LDH) in patients with metastatic CRC." | 2.87 | Prognostic Significance of Serum Lactic Acid, Lactate Dehydrogenase, and Albumin Levels in Patients with Metastatic Colorectal Cancer. ( Dai, J; Peng, J; Wang, W; Wei, Y; Xia, L; Xu, H; Zhou, F, 2018) |
| "Metabolic changes in cancer and metastasis upregulation of glycolysis is observed in many primary and metastatic cancers and aerobic glycolysis is the most favorable mechanism for glucose metabolism in cancer cells, and it is a kind of evolutionary change." | 2.72 | Digging deeper through glucose metabolism and its regulators in cancer and metastasis. ( Banihashemi, S; Deris Zayeri, Z; Ghanavat, M; Kazemi, SM; Saki, N; Shahrouzian, M, 2021) |
| "Moreover, many metastases display different metabolic traits compared with the tumours from which they originate, enabling survival and growth in the new environment." | 2.72 | The metabolism of cancer cells during metastasis. ( Bergers, G; Fendt, SM, 2021) |
| "Rather than a general switch promoting metastasis as a whole, a succession of metabolic adaptations is more likely needed to promote different steps of the metastatic process." | 2.53 | Metabolic changes associated with tumor metastasis, part 1: tumor pH, glycolysis and the pentose phosphate pathway. ( Baselet, B; Payen, VL; Porporato, PE; Sonveaux, P, 2016) |
| "Both cancer and diabetes have been associated with abnormal lactate metabolism and high level of lactate production is the key biological property of these diseases." | 2.53 | Lactate, a Neglected Factor for Diabetes and Cancer Interaction. ( Atefi, M; Dong, Y; Elshimali, Y; Liu, Y; Vadgama, JV; Wu, Y, 2016) |
| "Although anoikis is a barrier to metastasis, cancer cells have often acquired elevated threshold for anoikis and hence heightened metastatic potential." | 2.52 | The Warburg effect in tumor progression: mitochondrial oxidative metabolism as an anti-metastasis mechanism. ( Cai, Q; Lu, J; Tan, M, 2015) |
| "Low lactate tumors ( | 2.42 | Lactate: mirror and motor of tumor malignancy. ( Mueller-Klieser, WF; Walenta, S, 2004) |
| "The key biomolecules in the prostate cancer cells were identified to be tryptophan, reduced nicotinamide adenine dinucleotide (NADH) and hypothetically lactate as well." | 1.62 | Identifying metastatic ability of prostate cancer cell lines using native fluorescence spectroscopy and machine learning methods. ( Gao, X; Pu, Y; Smith, J; Wang, C; Wu, B; Xue, J, 2021) |
| "In solid tumors, hypoxia can trigger aberrant expression of transcription factors and genes, resulting in abnormal biological functions such as altered energetic pathways in cancer cells." | 1.56 | Computational modeling to determine key regulators of hypoxia effects on the lactate production in the glycolysis pathway. ( Hashemzadeh, S; Omidi, Y; Rafii-Tabar, H; Shahmorad, S, 2020) |
| "In the treatment of lung adenocarcinoma, targeting PFKFB3 would be a promising therapeutic strategy." | 1.48 | Expression of PFKFB3 and Ki67 in lung adenocarcinomas and targeting PFKFB3 as a therapeutic strategy. ( Ke, H; Li, X; Liu, J; Liu, Y; Qian, L; Tian, W; Yao, C; Zhang, J, 2018) |
| "Primary tumor growth, metastasis formation and TME phenotype were significantly different in LDH-A KD tumors compared with controls." | 1.48 | LDH-A regulates the tumor microenvironment via HIF-signaling and modulates the immune response. ( Blasberg, R; Cohen, IJ; Khanin, R; Koutcher, JA; Maeda, M; Mane, M; Moroz, E; Satagopan, J; Serganova, I; Shindo, M; Vemuri, K, 2018) |
| "PFKFB3 expression was examined using HNSCC tissue arrays." | 1.46 | Blockage of glycolysis by targeting PFKFB3 suppresses tumor growth and metastasis in head and neck squamous cell carcinoma. ( Chen, G; Jia, J; Li, HM; Liu, ZJ; Ren, JG; Wang, WM; Yang, JG; Yu, ZL; Zhang, W, 2017) |
| "Silver nanoparticles were entrapped inside the functionalized nanoparticles (Ag-PNP-CTX), to allow detection and quantification of the cellular uptake by confocal microscopy, both in vitro and in vivo." | 1.43 | A Combined Approach Employing Chlorotoxin-Nanovectors and Low Dose Radiation To Reach Infiltrating Tumor Niches in Glioblastoma. ( Corradini, I; Franchini, MC; Locatelli, E; Matteoli, M; Monaco, I; Passoni, L; Rasile, M; Rodighiero, S; Tamborini, M, 2016) |
| "Forced expression of miR-203 in ovarian cancer promoted cell growth and migration, while depletion of miR-203 inhibited the growth and migration of ovarian cancer cells." | 1.43 | MiR-203 promotes the growth and migration of ovarian cancer cells by enhancing glycolytic pathway. ( Kejian, Z; Lichun, F; Na, X; Shaosheng, W; Xiaohong, Z; Xiaolan, X, 2016) |
| "Lung cancer is the major cause of cancer related lethality worldwide, and metastasis to distant organs is the pivotal cause of death for the vast majority of lung cancer patients." | 1.42 | Active targeting docetaxel-PLA nanoparticles eradicate circulating lung cancer stem-like cells and inhibit liver metastasis. ( Hou, C; Jiang, Y; Liu, Y; Sun, B; Yang, N; Zhang, H; Zheng, J; Zuo, P, 2015) |
| "Cell studies using metastatic breast cancer cells demonstrated disruption of Src kinase involved in the cancer migration by albumin-dasatinib nano-shell and generation of photoactivated oxidative stress by mTHPC-PLGA nano-core." | 1.40 | A rationally designed photo-chemo core-shell nanomedicine for inhibiting the migration of metastatic breast cancer cells followed by photodynamic killing. ( Chandran, P; Gupta, N; Koyakutty, M; Malarvizhi, GL; Nair, S; Ramachandran, R; Retnakumari, AP, 2014) |
| "When wild-type KISS1 metastasis suppressor is expressed, aerobic glycolysis decreases and oxidative phosphorylation predominates." | 1.40 | Metastasis suppressor KISS1 seems to reverse the Warburg effect by enhancing mitochondrial biogenesis. ( Ballinger, SW; Beck, BH; Denning, WL; Dhar, A; Diers, AR; Feeley, KP; Iwakuma, T; Landar, A; Liu, W; Nash, KT; Pounds, KM; Vaidya, KS; Welch, DR, 2014) |
| "Briefly, human breast cancer cells (MCF7) were cultured with lactate or ketones, and then subjected to transcriptional analysis (exon-array)." | 1.37 | Ketones and lactate increase cancer cell "stemness," driving recurrence, metastasis and poor clinical outcome in breast cancer: achieving personalized medicine via Metabolo-Genomics. ( Ertel, A; Flomenberg, N; Howell, A; Knudsen, ES; Lin, Z; Lisanti, MP; Martinez-Outschoorn, UE; Pavlides, S; Pestell, RG; Prisco, M; Sotgia, F; Tsirigos, A; Wang, C, 2011) |
| "Human cancers consume larger amounts of glucose compared to normal tissues with most being converted and excreted as lactate despite abundant oxygen availability (Warburg effect)." | 1.37 | Posttranslational modification of 6-phosphofructo-1-kinase as an important feature of cancer metabolism. ( Legiša, M; Šmerc, A; Sodja, E, 2011) |
| "The high recurrence and lethality of ovarian cancer at advanced stages is problematic, especially due to the development of numerous micrometastases scattered throughout the abdominal cavity." | 1.35 | Benefits of nanoencapsulation for the hypercin-mediated photodetection of ovarian micrometastases. ( Delie, F; Gurny, R; Lange, N; Zeisser-Labouèbe, M, 2009) |
| "The melanoma cell metastasis to lungs was prevented by intravenous co-injection of B16BL6 melanoma cells with 1." | 1.33 | The effect of poly (aspartic acid-co-lactic acid) nanospheres on the lung metastasis of B16BL6 melanoma cells by intravenous administration. ( Hara, K; Huang, CC; Kawashima, Y; Mimura, H; Miwa, N; Tsujimoto, H, 2006) |
| "Accordingly, enhanced IFP in tumors is the result of high rates of tumor glycolysis, and enhancement of IFP is limited by MVP." | 1.30 | A biophysical basis of enhanced interstitial fluid pressure in tumors. ( Rutz, HP, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.89) | 18.7374 |
| 1990's | 2 (3.77) | 18.2507 |
| 2000's | 7 (13.21) | 29.6817 |
| 2010's | 36 (67.92) | 24.3611 |
| 2020's | 7 (13.21) | 2.80 |
| Authors | Studies |
|---|---|
| Jin, L | 1 |
| Guo, Y | 1 |
| Chen, J | 1 |
| Wen, Z | 1 |
| Jiang, Y | 2 |
| Qian, J | 1 |
| Fang, G | 1 |
| Zhang, P | 1 |
| Liu, J | 3 |
| Zhang, X | 1 |
| Zhu, X | 1 |
| Li, R | 1 |
| Wang, H | 1 |
| Singh, S | 1 |
| Pandey, S | 1 |
| Chawla, AS | 1 |
| Bhatt, AN | 1 |
| Roy, BG | 1 |
| Saluja, D | 1 |
| Dwarakanath, BS | 1 |
| Yan, L | 1 |
| Rust, BM | 1 |
| Picklo, MJ | 1 |
| Hashemzadeh, S | 1 |
| Shahmorad, S | 1 |
| Rafii-Tabar, H | 1 |
| Omidi, Y | 1 |
| Ghanavat, M | 1 |
| Shahrouzian, M | 1 |
| Deris Zayeri, Z | 1 |
| Banihashemi, S | 1 |
| Kazemi, SM | 1 |
| Saki, N | 1 |
| Mu, C | 1 |
| Korenchan, DE | 1 |
| Wang, S | 1 |
| Wilson, DM | 2 |
| Flavell, RR | 1 |
| Bergers, G | 1 |
| Fendt, SM | 1 |
| Xue, J | 1 |
| Pu, Y | 1 |
| Smith, J | 1 |
| Gao, X | 1 |
| Wang, C | 2 |
| Wu, B | 1 |
| Li, L | 1 |
| Kang, L | 1 |
| Zhao, W | 1 |
| Feng, Y | 1 |
| Liu, W | 2 |
| Wang, T | 1 |
| Mai, H | 1 |
| Huang, J | 1 |
| Chen, S | 1 |
| Liang, Y | 1 |
| Han, J | 1 |
| Xu, X | 1 |
| Ye, Q | 1 |
| Li, X | 1 |
| Qian, L | 1 |
| Ke, H | 1 |
| Yao, C | 1 |
| Tian, W | 1 |
| Liu, Y | 3 |
| Zhang, J | 1 |
| Serganova, I | 1 |
| Cohen, IJ | 1 |
| Vemuri, K | 1 |
| Shindo, M | 1 |
| Maeda, M | 1 |
| Mane, M | 1 |
| Moroz, E | 1 |
| Khanin, R | 1 |
| Satagopan, J | 1 |
| Koutcher, JA | 1 |
| Blasberg, R | 1 |
| Gendler, S | 1 |
| Shmilovich, H | 1 |
| Aranovich, D | 1 |
| Nadler, R | 1 |
| Kashtan, H | 1 |
| Stein, M | 1 |
| Wei, Y | 1 |
| Xu, H | 1 |
| Dai, J | 1 |
| Peng, J | 1 |
| Wang, W | 1 |
| Xia, L | 1 |
| Zhou, F | 1 |
| Malarvizhi, GL | 1 |
| Chandran, P | 1 |
| Retnakumari, AP | 1 |
| Ramachandran, R | 1 |
| Gupta, N | 1 |
| Nair, S | 1 |
| Koyakutty, M | 1 |
| Beck, BH | 1 |
| Vaidya, KS | 1 |
| Nash, KT | 1 |
| Feeley, KP | 1 |
| Ballinger, SW | 1 |
| Pounds, KM | 1 |
| Denning, WL | 1 |
| Diers, AR | 1 |
| Landar, A | 1 |
| Dhar, A | 1 |
| Iwakuma, T | 1 |
| Welch, DR | 1 |
| Guo, S | 1 |
| Lin, CM | 1 |
| Xu, Z | 1 |
| Miao, L | 1 |
| Wang, Y | 1 |
| Huang, L | 1 |
| Lu, J | 1 |
| Tan, M | 1 |
| Cai, Q | 1 |
| Yang, N | 1 |
| Zhang, H | 1 |
| Sun, B | 1 |
| Hou, C | 1 |
| Zheng, J | 1 |
| Zuo, P | 1 |
| Büll, C | 1 |
| Boltje, TJ | 1 |
| van Dinther, EA | 1 |
| Peters, T | 1 |
| de Graaf, AM | 1 |
| Leusen, JH | 1 |
| Kreutz, M | 1 |
| Figdor, CG | 1 |
| den Brok, MH | 1 |
| Adema, GJ | 1 |
| Porcelli, L | 1 |
| Guida, G | 1 |
| Quatrale, AE | 1 |
| Cocco, T | 1 |
| Sidella, L | 1 |
| Maida, I | 1 |
| Iacobazzi, RM | 1 |
| Ferretta, A | 1 |
| Stolfa, DA | 1 |
| Strippoli, S | 1 |
| Guida, S | 1 |
| Tommasi, S | 1 |
| Guida, M | 1 |
| Azzariti, A | 1 |
| Kaur, J | 1 |
| Tikoo, K | 1 |
| Giannoni, E | 1 |
| Taddei, ML | 1 |
| Morandi, A | 1 |
| Comito, G | 1 |
| Calvani, M | 1 |
| Bianchini, F | 1 |
| Richichi, B | 1 |
| Raugei, G | 1 |
| Wong, N | 1 |
| Tang, D | 1 |
| Chiarugi, P | 1 |
| Gao, DY | 1 |
| Lin, TsT | 1 |
| Sung, YC | 1 |
| Liu, YC | 1 |
| Chiang, WH | 1 |
| Chang, CC | 1 |
| Liu, JY | 1 |
| Chen, Y | 1 |
| Payen, VL | 1 |
| Porporato, PE | 2 |
| Baselet, B | 1 |
| Sonveaux, P | 2 |
| Tamborini, M | 1 |
| Locatelli, E | 1 |
| Rasile, M | 1 |
| Monaco, I | 1 |
| Rodighiero, S | 1 |
| Corradini, I | 1 |
| Franchini, MC | 1 |
| Passoni, L | 1 |
| Matteoli, M | 1 |
| Zhu, W | 1 |
| Lee, SJ | 1 |
| Castro, NJ | 1 |
| Yan, D | 1 |
| Keidar, M | 1 |
| Zhang, LG | 1 |
| Graboń, W | 1 |
| Otto-Ślusarczyk, D | 1 |
| Chrzanowska, A | 1 |
| Mielczarek-Puta, M | 1 |
| Joniec-Maciejak, I | 1 |
| Słabik, K | 1 |
| Barańczyk-Kuźma, A | 1 |
| Verma, RK | 1 |
| Yu, W | 1 |
| Shrivastava, A | 1 |
| Shankar, S | 1 |
| Srivastava, RK | 1 |
| Xiaohong, Z | 1 |
| Lichun, F | 1 |
| Na, X | 1 |
| Kejian, Z | 1 |
| Xiaolan, X | 1 |
| Shaosheng, W | 1 |
| Häggblad Sahlberg, S | 1 |
| Mortensen, AC | 1 |
| Haglöf, J | 1 |
| Engskog, MK | 1 |
| Arvidsson, T | 1 |
| Pettersson, C | 1 |
| Glimelius, B | 1 |
| Stenerlöw, B | 1 |
| Nestor, M | 1 |
| Ferrando-Vivas, P | 1 |
| Jones, A | 1 |
| Rowan, KM | 1 |
| Harrison, DA | 1 |
| Li, HM | 1 |
| Yang, JG | 1 |
| Liu, ZJ | 1 |
| Wang, WM | 1 |
| Yu, ZL | 1 |
| Ren, JG | 1 |
| Chen, G | 1 |
| Zhang, W | 1 |
| Jia, J | 1 |
| Wu, Y | 1 |
| Dong, Y | 1 |
| Atefi, M | 1 |
| Elshimali, Y | 1 |
| Vadgama, JV | 1 |
| Zeisser-Labouèbe, M | 1 |
| Delie, F | 1 |
| Gurny, R | 1 |
| Lange, N | 1 |
| Ravindran, J | 1 |
| Nair, HB | 1 |
| Sung, B | 1 |
| Prasad, S | 1 |
| Tekmal, RR | 1 |
| Aggarwal, BB | 1 |
| LaBan, MM | 1 |
| Nagarajan, R | 1 |
| Riutta, JC | 1 |
| Martinez-Outschoorn, UE | 1 |
| Prisco, M | 1 |
| Ertel, A | 1 |
| Tsirigos, A | 1 |
| Lin, Z | 1 |
| Pavlides, S | 1 |
| Flomenberg, N | 1 |
| Knudsen, ES | 1 |
| Howell, A | 1 |
| Pestell, RG | 1 |
| Sotgia, F | 1 |
| Lisanti, MP | 1 |
| Šmerc, A | 1 |
| Sodja, E | 1 |
| Legiša, M | 1 |
| Ramanlal Chaudhari, K | 1 |
| Kumar, A | 1 |
| Megraj Khandelwal, VK | 1 |
| Ukawala, M | 1 |
| Manjappa, AS | 1 |
| Mishra, AK | 1 |
| Monkkonen, J | 1 |
| Ramachandra Murthy, RS | 1 |
| Dhup, S | 1 |
| Dadhich, RK | 1 |
| Thamake, SI | 1 |
| Raut, SL | 1 |
| Gryczynski, Z | 1 |
| Ranjan, AP | 1 |
| Vishwanatha, JK | 1 |
| Li, Y | 1 |
| Yang, F | 1 |
| Chen, W | 1 |
| Huang, W | 1 |
| Jin, M | 1 |
| Gao, Z | 1 |
| Keshari, KR | 1 |
| Sriram, R | 1 |
| Koelsch, BL | 1 |
| Van Criekinge, M | 1 |
| Kurhanewicz, J | 1 |
| Wang, ZJ | 1 |
| Hwang, YH | 1 |
| Suh, CK | 1 |
| Park, SP | 1 |
| RAMKISSOON, RA | 1 |
| CHAMBERLAIN, NO | 1 |
| BAKER, EL | 1 |
| JENNINGS, ER | 1 |
| Walenta, S | 3 |
| Mueller-Klieser, WF | 1 |
| Hara, K | 1 |
| Tsujimoto, H | 1 |
| Huang, CC | 1 |
| Kawashima, Y | 1 |
| Mimura, H | 1 |
| Miwa, N | 1 |
| Chawla, A | 1 |
| Emmanuel, JV | 1 |
| Seow, WT | 1 |
| Lou, J | 1 |
| Teo, HE | 1 |
| Lim, CC | 1 |
| Sawyer, AJ | 1 |
| Piepmeier, JM | 1 |
| Saltzman, WM | 1 |
| Schwickert, G | 2 |
| Sundfør, K | 2 |
| Rofstad, EK | 2 |
| Mueller-Klieser, W | 2 |
| Rutz, HP | 1 |
| Wetterling, M | 1 |
| Lehrke, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of the Safety and Efficacy of Esperanza Extract (Petiveria Alliacea) in Patients With Metastatic Gastrointestinal Tumors and Acute Leukemia[NCT05587088] | Phase 1/Phase 2 | 82 participants (Anticipated) | Interventional | 2022-12-15 | Not yet recruiting | ||
| What Are the Factors Affecting Neoadjuvant Chemotherapy Efficacy in Breast Cancer? A Non-invasive in Vivo Study Using Specialist Magnetic Resonance (MR) Methods[NCT03501394] | 25 participants (Anticipated) | Interventional | 2018-05-02 | Recruiting | |||
| Trial of Dichloroacetate (DCA) in Glioblastoma Multiforme (GBM)[NCT05120284] | Phase 2 | 40 participants (Anticipated) | Interventional | 2022-07-01 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
10 reviews available for lactic acid and Neoplasm Metastasis
| Article | Year |
|---|---|
Digging deeper through glucose metabolism and its regulators in cancer and metastasis.
Topics: Animals; Biomarkers, Tumor; Carbohydrate Metabolism; Glucose; Glycolysis; Humans; Lactic Acid; Neopl | 2021 |
Tumor Microenvironment Biosensors for Hyperpolarized Carbon-13 Magnetic Resonance Spectroscopy.
Topics: Animals; Biosensing Techniques; Carbon Isotopes; Carbon-13 Magnetic Resonance Spectroscopy; Cold Tem | 2021 |
The metabolism of cancer cells during metastasis.
Topics: Acetates; Adenosine Triphosphate; Animals; Cell Plasticity; Fatty Acids; Glutamine; Humans; Lactic A | 2021 |
The Warburg effect in tumor progression: mitochondrial oxidative metabolism as an anti-metastasis mechanism.
Topics: Anoikis; Cell Proliferation; Citric Acid Cycle; Glucose; Glycolysis; Humans; Hypoxia-Inducible Facto | 2015 |
Metabolic changes associated with tumor metastasis, part 1: tumor pH, glycolysis and the pentose phosphate pathway.
Topics: Epithelial-Mesenchymal Transition; Glucose-6-Phosphate Isomerase; Glycolysis; Humans; Lactic Acid; N | 2016 |
Lactate, a Neglected Factor for Diabetes and Cancer Interaction.
Topics: Animals; Cell Line, Tumor; Diabetes Complications; Diabetes Mellitus; Disease Progression; Humans; H | 2016 |
Paucity of muscle metastasis in otherwise widely disseminated cancer: a conundrum.
Topics: Diagnostic Imaging; Edema; Humans; Lactic Acid; Muscle Neoplasms; Muscle, Skeletal; Neoplasm Metasta | 2010 |
Multiple biological activities of lactic acid in cancer: influences on tumor growth, angiogenesis and metastasis.
Topics: Humans; Lactic Acid; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms; Neovascularization, Path | 2012 |
Lactate: mirror and motor of tumor malignancy.
Topics: Cell Hypoxia; Cell Transformation, Neoplastic; Female; Humans; Hyaluronic Acid; Hypoxia-Inducible Fa | 2004 |
New methods for direct delivery of chemotherapy for treating brain tumors.
Topics: Antineoplastic Agents; Biocompatible Materials; Brain Neoplasms; Clinical Trials as Topic; Drug Carr | 2006 |
1 trial available for lactic acid and Neoplasm Metastasis
| Article | Year |
|---|---|
Prognostic Significance of Serum Lactic Acid, Lactate Dehydrogenase, and Albumin Levels in Patients with Metastatic Colorectal Cancer.
Topics: Adult; Aged; Colorectal Neoplasms; Disease-Free Survival; Female; Humans; L-Lactate Dehydrogenase; L | 2018 |
42 other studies available for lactic acid and Neoplasm Metastasis
| Article | Year |
|---|---|
Lactate receptor HCAR1 regulates cell growth, metastasis and maintenance of cancer‑specific energy metabolism in breast cancer cells.
Topics: Breast Neoplasms; Cell Growth Processes; Cell Line, Tumor; Energy Metabolism; Female; Glycolysis; Hu | 2022 |
Inhibition of GSK-3β activity suppresses HCC malignant phenotype by inhibiting glycolysis via activating AMPK/mTOR signaling.
Topics: Adenosine Triphosphate; AMP-Activated Protein Kinases; Antibodies, Monoclonal, Humanized; Carcinoma, | 2019 |
Dietary 2-deoxy-D-glucose impairs tumour growth and metastasis by inhibiting angiogenesis.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Angiogenesis Inhibitors; Animals; Antimetabolites; Ca | 2019 |
Plasma Metabolomic Changes in Mice With Time-restricted Feeding-attenuated Spontaneous Metastasis of Lewis Lung Carcinoma.
Topics: alpha-Tocopherol; Animals; Carcinoma, Lewis Lung; Cholestanol; Cholesterol; Diet, High-Fat; Disease | 2020 |
Computational modeling to determine key regulators of hypoxia effects on the lactate production in the glycolysis pathway.
Topics: Gene Expression; Glycolysis; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Lactic Acid | 2020 |
Identifying metastatic ability of prostate cancer cell lines using native fluorescence spectroscopy and machine learning methods.
Topics: Cell Line, Tumor; Humans; Lactic Acid; Machine Learning; Male; NAD; Neoplasm Metastasis; Principal C | 2021 |
miR-30a-5p suppresses breast tumor growth and metastasis through inhibition of LDHA-mediated Warburg effect.
Topics: 3' Untranslated Regions; Animals; Binding Sites; Breast Neoplasms; Cell Line, Tumor; Cell Movement; | 2017 |
Expression of PFKFB3 and Ki67 in lung adenocarcinomas and targeting PFKFB3 as a therapeutic strategy.
Topics: A549 Cells; Adenocarcinoma; Adenocarcinoma of Lung; Adult; Aged; Aged, 80 and over; Apoptosis; Bioma | 2018 |
LDH-A regulates the tumor microenvironment via HIF-signaling and modulates the immune response.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Female; Gene Knockdown Techniques; Humans; Hypoxia-Indu | 2018 |
Urgent Laparotomy in Patients with Metastatic Colorectal Cancer Presenting as an Acute Abdomen: A Retrospective Analysis.
Topics: Abdomen, Acute; Adult; Age Factors; Aged; Aged, 80 and over; Colorectal Neoplasms; Female; Hospital | 2018 |
A rationally designed photo-chemo core-shell nanomedicine for inhibiting the migration of metastatic breast cancer cells followed by photodynamic killing.
Topics: Breast; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Dasatinib; Drug Carriers; Female; Humans; | 2014 |
Metastasis suppressor KISS1 seems to reverse the Warburg effect by enhancing mitochondrial biogenesis.
Topics: Animals; Cell Line, Tumor; Disease Models, Animal; Extracellular Space; Female; Gene Expression; Glu | 2014 |
Co-delivery of cisplatin and rapamycin for enhanced anticancer therapy through synergistic effects and microenvironment modulation.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Chromatography, High Pressure Liquid; C | 2014 |
Active targeting docetaxel-PLA nanoparticles eradicate circulating lung cancer stem-like cells and inhibit liver metastasis.
Topics: AC133 Antigen; Animals; Antigens, CD; Antineoplastic Agents; Body Weight; Cell Line, Tumor; Docetaxe | 2015 |
Targeted delivery of a sialic acid-blocking glycomimetic to cancer cells inhibits metastatic spread.
Topics: Animals; Antibodies; Biomimetic Materials; Drug Carriers; Female; Lactic Acid; Lung Neoplasms; Melan | 2015 |
Aurora kinase B inhibition reduces the proliferation of metastatic melanoma cells and enhances the response to chemotherapy.
Topics: Albumins; Apoptosis; Aurora Kinase B; Cell Line, Tumor; Cell Movement; Cell Nucleus Shape; Cell Prol | 2015 |
Ets1 identified as a novel molecular target of RNA aptamer selected against metastatic cells for targeted delivery of nano-formulation.
Topics: Animals; Antineoplastic Agents; Aptamers, Nucleotide; Cell Line, Tumor; Cell Membrane Permeability; | 2015 |
Targeting stromal-induced pyruvate kinase M2 nuclear translocation impairs oxphos and prostate cancer metastatic spread.
Topics: Active Transport, Cell Nucleus; Animals; Binding Sites; Carcinoma; Carrier Proteins; Cell Line, Tumo | 2015 |
CXCR4-targeted lipid-coated PLGA nanoparticles deliver sorafenib and overcome acquired drug resistance in liver cancer.
Topics: Animals; Carcinoma, Hepatocellular; Cell Death; Cell Line, Tumor; Cell Proliferation; Drug Delivery | 2015 |
A Combined Approach Employing Chlorotoxin-Nanovectors and Low Dose Radiation To Reach Infiltrating Tumor Niches in Glioblastoma.
Topics: Animals; Blood-Brain Barrier; Brain Neoplasms; Cell Line, Tumor; Chemoradiotherapy; Chloride Channel | 2016 |
Synergistic Effect of Cold Atmospheric Plasma and Drug Loaded Core-shell Nanoparticles on Inhibiting Breast Cancer Cell Growth.
Topics: Antineoplastic Agents; Breast Neoplasms; Combined Modality Therapy; Drug Carriers; Humans; Lactic Ac | 2016 |
Lactate Formation in Primary and Metastatic Colon Cancer Cells at Hypoxia and Normoxia.
Topics: Aspartate Aminotransferases; Aspartic Acid; Cell Count; Cell Hypoxia; Cell Line, Tumor; Colonic Neop | 2016 |
α-Mangostin-encapsulated PLGA nanoparticles inhibit pancreatic carcinogenesis by targeting cancer stem cells in human, and transgenic (Kras(G12D), and Kras(G12D)/tp53R270H) mice.
Topics: Animals; Antigens, CD; Apoptosis; Cadherins; Carcinogenesis; Cell Line, Tumor; Cell Movement; Cell S | 2016 |
MiR-203 promotes the growth and migration of ovarian cancer cells by enhancing glycolytic pathway.
Topics: 3' Untranslated Regions; Animals; Carcinogenesis; Cell Line, Tumor; Cell Movement; Cell Proliferatio | 2016 |
Different functions of AKT1 and AKT2 in molecular pathways, cell migration and metabolism in colon cancer cells.
Topics: Alanine; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colonic Neoplasms; Fatty Ac | 2017 |
Development and validation of the new ICNARC model for prediction of acute hospital mortality in adult critical care.
Topics: Adult; Age Factors; Aged; Blood Glucose; Cardiopulmonary Resuscitation; Chronic Disease; Creatinine; | 2017 |
Blockage of glycolysis by targeting PFKFB3 suppresses tumor growth and metastasis in head and neck squamous cell carcinoma.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line, Tumor; | 2017 |
Benefits of nanoencapsulation for the hypercin-mediated photodetection of ovarian micrometastases.
Topics: Animals; Anthracenes; Disease Models, Animal; Drug Delivery Systems; Endoscopy; Female; Fluorescence | 2009 |
Thymoquinone poly (lactide-co-glycolide) nanoparticles exhibit enhanced anti-proliferative, anti-inflammatory, and chemosensitization potential.
Topics: Anti-Inflammatory Agents; Apoptosis; Benzoquinones; Cell Line, Tumor; Cell Proliferation; Drug Carri | 2010 |
Ketones and lactate increase cancer cell "stemness," driving recurrence, metastasis and poor clinical outcome in breast cancer: achieving personalized medicine via Metabolo-Genomics.
Topics: Acetyl Coenzyme A; Biomarkers, Tumor; Breast Neoplasms; Cell Line, Tumor; Citric Acid Cycle; Female; | 2011 |
Posttranslational modification of 6-phosphofructo-1-kinase as an important feature of cancer metabolism.
Topics: Animals; Blotting, Western; Cell Line, Tumor; DNA, Complementary; Endopeptidase K; Escherichia coli; | 2011 |
Bone metastasis targeting: a novel approach to reach bone using Zoledronate anchored PLGA nanoparticle as carrier system loaded with Docetaxel.
Topics: Animals; Antineoplastic Agents; Bone Density Conservation Agents; Bone Neoplasms; Cell Line; Cell Li | 2012 |
Alendronate coated poly-lactic-co-glycolic acid (PLGA) nanoparticles for active targeting of metastatic breast cancer.
Topics: Alendronate; Animals; Antineoplastic Agents; Bone and Bones; Bone Neoplasms; Boronic Acids; Bortezom | 2012 |
A novel monomethoxy polyethylene glycol-polylactic acid polymeric micelles with higher loading capacity for docetaxel and well-reconstitution characteristics and its anti-metastasis study.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Docetaxel; Drug Carriers; Guinea Pi | 2012 |
Hyperpolarized 13C-pyruvate magnetic resonance reveals rapid lactate export in metastatic renal cell carcinomas.
Topics: Carbon Isotopes; Carcinoma, Renal Cell; Cell Line; Cell Line, Tumor; Glycolysis; Humans; Kidney Tubu | 2013 |
Multifocal inflammatory leukoencephalopathy: use of thallium-201 SPECT and proton MRS.
Topics: Adjuvants, Immunologic; Antimetabolites, Antineoplastic; Aspartic Acid; Axons; Biopsy; Brain; Brain | 2003 |
DIAGNOSTIC SIGNIFICANCE OF URINARY LACTIC ACID DEHYDROGENASE.
Topics: Adenocarcinoma; Albuminuria; Carcinoma, Papillary; Carcinoma, Transitional Cell; Clinical Enzyme Tes | 1964 |
The effect of poly (aspartic acid-co-lactic acid) nanospheres on the lung metastasis of B16BL6 melanoma cells by intravenous administration.
Topics: Animals; Biocompatible Materials; Cell Line, Tumor; Delayed-Action Preparations; Injections, Intrave | 2006 |
Paediatric PNET: pre-surgical MRI features.
Topics: Aspartic Acid; Cerebrospinal Fluid; Child; Child, Preschool; Choline; Creatine; Databases, Factual; | 2007 |
Correlation of high lactate levels in human cervical cancer with incidence of metastasis.
Topics: Adenosine Triphosphate; Biopsy; Female; Glucose; Humans; Lactates; Lactic Acid; Luminescent Measurem | 1995 |
A biophysical basis of enhanced interstitial fluid pressure in tumors.
Topics: Animals; Biophysical Phenomena; Biophysics; Carbon Dioxide; Extracellular Space; Glucose; Glycolysis | 1999 |
High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers.
Topics: Adenosine Triphosphate; Female; Humans; Lactic Acid; Neoplasm Metastasis; Neoplasm Recurrence, Local | 2000 |