lactic acid has been researched along with Myocardial Ischemia in 329 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fluorouracil (FU) is a cornerstone of colorectal cancer treatment; however, it has clinical and subclinical influence on the heart." | 9.14 | Fluorouracil induces myocardial ischemia with increases of plasma brain natriuretic peptide and lactic acid but without dysfunction of left ventricle. ( Hasbak, P; Jensen, SA; Mortensen, J; Sørensen, JB, 2010) |
| "Experiments on rats with acute myocardial ischemia accompanied by early postocclusive arrhythmias have shown normalizing, energy-stabilizing, and antiarrhythmic effects of uridine and uridine-5'-monophosphate." | 7.80 | Antiarrhythmic effect of uridine and uridine-5'-monophosphate in acute myocardial ischemia. ( Bul'on, VV; Evdokimova, NR; Krylova, IB; Mironova, GD; Rodionova, OM; Sapronov, NS; Selina, EN, 2014) |
| "We examined whether pharmacological inhibition of glycogenolysis by N-methyl-1-deoxynojirimycin (MOR-14), a new compound which reduces the glycogenolytic rate by inhibiting the alpha-1,6-glucosidase activity of the glycogen-debranching enzyme, can protect the heart against postischemic left ventricular dysfunction." | 7.70 | N-methyl-1-deoxynojirimycin (MOR-14), an alpha-glucosidase inhibitor, markedly improves postischemic left ventricular dysfunction. ( Arai, M; Chen, XH; Fujiwara, H; Fujiwara, T; Hashimoto, K; Minatoguchi, S; Nishida, Y; Takemura, G; Uno, Y; Wang, N, 2000) |
| "The changes in endothelium-derived vascular regulatory factors during dobutamine (DOB)-induced myocardial ischemia (MI) were investigated in 21 patients with Kawasaki disease aged from 11 months to 18 years." | 7.70 | Changes in endothelium-derived vascular regulatory factors during dobutamine-stress-induced silent myocardial ischemia in patients with Kawasaki disease. ( Hino, Y; Katsube, Y; Ogawa, S; Ohkubo, T, 1999) |
| "The purpose of this study was to determine whether the acute and chronic administration of cocaine could induce myocardial infarction." | 7.69 | Acute and chronic cocaine exposure can produce myocardial ischemia and infarction in Yucatan swine. ( Carrozza, JP; Klein, MA; Miao, L; Morgan, JP; Núñez, BD; Núñez, MM; Ross, JN; Travers, KE, 1997) |
| " The aim of this study was to investigate the coronary vascular effects of dexmedetomidine (DM) during reactive hyperemia." | 7.69 | Coronary vascular effects of dexmedetomidine during reactive hyperemia in the anesthetized dog. ( de Lange, S; Prinzen, FW; Roekaerts, PM, 1996) |
| "A hemodialysed patient with abdominal pain, severe lactic acidosis and prolonged hypoglycemia is described." | 7.69 | Acute necrotizing pancreatitis, lactic acidosis and prolonged hypoglycemia in a hemodialysed patient--a logical but unfortunately fatal combination. ( Chagnac, A; Gafter, U; Halperin, M; Korzets, A; Ori, Y; Weinstein, T; Zevin, D, 1996) |
| "For glycerol, there was a further increase at reperfusion." | 5.33 | Myocardial glycerol release, arrhythmias and hemodynamic instability during regional ischemia-reperfusion in an open chest pig model. ( Algotsson, L; Liao, Q; Metzsch, C; Steen, S, 2006) |
| "Pretreatment with deferoxamine (10 mg/kg, n = 7) or dimethylthiourea (10 mg/kg, n = 6) decreased net production of HO." | 5.29 | Hydroxyl radical production during myocardial ischemia and reperfusion in cats. ( Fu, LW; Halliwell, B; Longhurst, JC; O'Neill, CA, 1996) |
| "Fluorouracil (FU) is a cornerstone of colorectal cancer treatment; however, it has clinical and subclinical influence on the heart." | 5.14 | Fluorouracil induces myocardial ischemia with increases of plasma brain natriuretic peptide and lactic acid but without dysfunction of left ventricle. ( Hasbak, P; Jensen, SA; Mortensen, J; Sørensen, JB, 2010) |
| "Forty-one patients operated on for isolated aortic valve stenosis were randomly assigned to continuous coronary infusion with either potassium or esmolol during cardiopulmonary bypass." | 5.10 | Efficacy of esmolol as a myocardial protective agent during continuous retrograde blood cardioplegia. ( Al Attar, N; Callebert, J; Lessana, A; Maillet, JM; Mebazaa, A; Medini, B; Nataf, P; Payen, D; Raffoul, R; Ramadan, R; Ruffenach, A; Scorsin, M; Simoneau, F, 2003) |
| "In 70 mechanically-ventilated patients with septic shock, we examined: a) S' and E' mitral annular velocities using tissue Doppler imaging (TDI), b) CFR of the left anterior descending artery after adenosine infusion using transesophageal Doppler echocardiography and c) lactate, pyruvate and glycerol in tissue by means of a microdialysis (MD) catheter inserted into the subcutaneous adipose tissue as markers of tissue ischemia and acidosis." | 3.80 | Coronary flow reserve is associated with tissue ischemia and is an additive predictor of intensive care unit mortality to traditional risk scores in septic shock. ( Armaganidis, A; Diamantakis, A; Dimopoulou, I; Ikonomidis, I; Kopterides, P; Lekakis, J; Makavos, G; Nikitas, N; Paraskevaidis, I; Parissis, J; Theodorakopoulou, M, 2014) |
| "Experiments on rats with acute myocardial ischemia accompanied by early postocclusive arrhythmias have shown normalizing, energy-stabilizing, and antiarrhythmic effects of uridine and uridine-5'-monophosphate." | 3.80 | Antiarrhythmic effect of uridine and uridine-5'-monophosphate in acute myocardial ischemia. ( Bul'on, VV; Evdokimova, NR; Krylova, IB; Mironova, GD; Rodionova, OM; Sapronov, NS; Selina, EN, 2014) |
| " In this study, hemodynamics, transmural high-energy phosphate (HEP), 2-deoxyglucose-6-phosphate (2-DGP) levels, and myocardial blood flow (MBF) were determined under basal conditions, during dobutamine infusion (DOB: 20 microg x kg(-1) x min(-1) iv), and during coronary stenosis + DOB + 2-deoxyglucose (2-DG) infusion." | 3.74 | Transmural distribution of metabolic abnormalities and glycolytic activity during dobutamine-induced demand ischemia. ( Eijgelshoven, MH; Jameel, MN; Mansoor, A; Wang, X; Zhang, J, 2008) |
| "Levosimendan used throughout myocardial ischemia-reperfusion might have a cardioprotective affect on the response to myocardial ischemia as compared with levosimendan started during the ischemia." | 3.74 | Levosimendan cardioprotection reduces the metabolic response during temporary regional coronary occlusion in an open chest pig model. ( Algotsson, L; Liao, Q; Metzsch, C; Steen, S, 2007) |
| " Myocardial ischemia after coronary angioplasty was evaluated in 20 nondiabetic and 23 diabetic patients chronically taking either glibenclamide or glimepiride." | 3.72 | Impairment of myocardial protection in type 2 diabetic patients. ( Chou, TF; Lee, TM, 2003) |
| "To examine the effect of acebutolol, a beta-adrenergic-receptor blocker, on severe regional myocardial ischemia, specifically the effects on regional myocardial function and metabolism." | 3.71 | Beta-adrenergic blockade during severe ischemia. ( Coetzee, A; Coetzee, G, 2002) |
| "We examined whether pharmacological inhibition of glycogenolysis by N-methyl-1-deoxynojirimycin (MOR-14), a new compound which reduces the glycogenolytic rate by inhibiting the alpha-1,6-glucosidase activity of the glycogen-debranching enzyme, can protect the heart against postischemic left ventricular dysfunction." | 3.70 | N-methyl-1-deoxynojirimycin (MOR-14), an alpha-glucosidase inhibitor, markedly improves postischemic left ventricular dysfunction. ( Arai, M; Chen, XH; Fujiwara, H; Fujiwara, T; Hashimoto, K; Minatoguchi, S; Nishida, Y; Takemura, G; Uno, Y; Wang, N, 2000) |
| "The changes in endothelium-derived vascular regulatory factors during dobutamine (DOB)-induced myocardial ischemia (MI) were investigated in 21 patients with Kawasaki disease aged from 11 months to 18 years." | 3.70 | Changes in endothelium-derived vascular regulatory factors during dobutamine-stress-induced silent myocardial ischemia in patients with Kawasaki disease. ( Hino, Y; Katsube, Y; Ogawa, S; Ohkubo, T, 1999) |
| "In this study, we demonstrated stereoselective differences in the biologic action of the two ketamine isomers in an animal model of myocardial ischemia." | 3.70 | S(+)-ketamine, but not R(-)-ketamine, reduces postischemic adherence of neutrophils in the coronary system of isolated guinea pig hearts. ( Becker, BF; Conzen, PF; Heindl, B; Szekely, A; Zahler, S, 1999) |
| " The effects of diltiazem, verapamil, and nifedipine on extracellular potassium concentration ([K+]e), acidosis, and level of metabolic markers were examined during 30-min global ischemia and postischemic left ventricular (LV) function in isolated guinea pig hearts." | 3.70 | Temporal differences in actions of calcium channel blockers on K+ accumulation, cardiac function, and high-energy phosphate levels in ischemic guinea pig hearts. ( Nagao, T; Sato, R; Yamazaki, J, 1999) |
| "The purpose of this study was to determine whether the acute and chronic administration of cocaine could induce myocardial infarction." | 3.69 | Acute and chronic cocaine exposure can produce myocardial ischemia and infarction in Yucatan swine. ( Carrozza, JP; Klein, MA; Miao, L; Morgan, JP; Núñez, BD; Núñez, MM; Ross, JN; Travers, KE, 1997) |
| " The purpose of this study was to assess the effects of felodipine as a potentially protective agent against myocardial ischemia and reperfusion injury, independent of any negative inotropic actions, when given after the onset of low-flow ischemia." | 3.69 | Beneficial effects of felodipine on myocardial and coronary function during low-flow ischemia and reperfusion. ( Apstein, CS; Bernstein, EA; Eberli, FR; Horowitz, GL; Silverman, AM, 1996) |
| "To determine the frequency of true myocardial ischemia caused by hemodynamic, metabolic, and regional functional abnormalities after intravenous adenosine infusion in patients with coronary artery disease, 13 patients--11 with coronary artery disease--received intravenous adenosine and thallium 201 during cardiac catheterization." | 3.69 | Correlation of adenosine thallium 201 perfusion patterns with markers for inducible ischemia. ( Beller, GA; Camarano, G; Ellis, M; Feldman, MD; Fenster, MS; Johnson, WH; Linden, J, 1997) |
| "Without esmolol, dobutamine stress induced myocardial ischemia with a reduction in regional wall thickening and lactate production in all nine pigs." | 3.69 | Effects of beta-blockade and atropine on ischemic responses in left ventricular regions subtending coronary stenosis during dobutamine stress echocardiography. ( Chen, C; Chen, L; Chen, M; de Prada, VA; Feng, YJ; Gillam, L; Ma, L; Waters, D, 1996) |
| "Isovolumetric rat hearts (37 degrees C) were treated with 1 microM (apri 1) or 30 microM (apri 30) aprikalim, or preconditioned with either 10 min of hypoxia (N2PC) or 5 min of ischaemia followed by 5 min of perfusion (IPC5) or 10 min of ischaemia followed by 3 min of perfusion (IPC10)." | 3.69 | Comparison of effects of aprikalim and of hypoxic and ischaemic preconditioning on extracellular potassium accumulation, metabolism, and functional recovery of the globally ischaemic rat heart. ( Diacono, J; Feuvray, D; Guo, AC, 1994) |
| " The aim of this study was to investigate the coronary vascular effects of dexmedetomidine (DM) during reactive hyperemia." | 3.69 | Coronary vascular effects of dexmedetomidine during reactive hyperemia in the anesthetized dog. ( de Lange, S; Prinzen, FW; Roekaerts, PM, 1996) |
| "A hemodialysed patient with abdominal pain, severe lactic acidosis and prolonged hypoglycemia is described." | 3.69 | Acute necrotizing pancreatitis, lactic acidosis and prolonged hypoglycemia in a hemodialysed patient--a logical but unfortunately fatal combination. ( Chagnac, A; Gafter, U; Halperin, M; Korzets, A; Ori, Y; Weinstein, T; Zevin, D, 1996) |
| " There was no evidence of myocardial ischemia, as demonstrated by absence of S-T depression on the electrocardiogram, lactate extraction, or hypoxanthine release." | 3.68 | Myocardial metabolism and adaptation during extreme hemodilution in humans after coronary revascularization. ( Blakeman, B; Dries, DJ; Kleinman, B; Kumar, P; Mathru, M; Sullivan, H, 1992) |
| "We conclude that 1) in sustained myocardial ischemia, SOD treatment attenuates ischemic injury caused by coronary microembolization by restoration of 5'-nucleotidase activity and augmentation of adenosine release; 2) this beneficial effect of SOD is observed even after coronary microembolization; and 3) the beneficial effects of SOD are attributable to coronary vasodilation produced by augmented adenosine release." | 3.68 | Superoxide dismutase restores contractile and metabolic dysfunction through augmentation of adenosine release in coronary microembolization. ( Hori, M; Inoue, M; Kamada, T; Kitakaze, M; Sato, H; Takashima, S, 1993) |
| "One patient in group T developed low cardiac output syndrome 48 hours after the operation and died after 1 month." | 2.71 | Markers of myocardial ischemia in the evaluation of the effect of left anterior descending coronary artery lesion and collateral circulation on myocardial injury in 1-vessel off-pump coronary bypass surgery. ( Alp, M; Güzelmeriç, F; Kayalar, N; Kirali, K; Mansuroğlu, D; Yakut, C, 2003) |
| "During fasting, NIDDM hearts demonstrated lower fractional extraction of glucose from arterial plasma than controls (1." | 2.70 | Effect of non-insulin-dependent diabetes mellitus on myocardial insulin responsiveness in patients with ischemic heart disease. ( Concato, J; Jagasia, D; McNulty, PH; Pfau, S; Whiting, JM, 2001) |
| " Similarly, no adverse changes occurred in systemic or pulmonary arterial pressures or in cardiac ejection fraction." | 2.67 | Safety of low-dose intraoperative bicarbonate therapy: a prospective, double-blind, randomized study. The Study of Perioperative Ischemia (SPI) Research Group. ( Arieff, AI; Leung, JM; Mangano, DT; Mark, NH, 1993) |
| "Notably, despite the 5 min of cardiac arrest in the treated group, both the lactate and bicarbonate levels were maintained without significant variation." | 1.56 | Interventionist videothermometry: a new model of cardiac ischemia evaluation. ( Antunes, F; Cabral, PGA; Cadena, SMR; da Mota Costa, MR; da Silva, TOB; de Abreu Oliveira, AL; de Moura Vidal, LW; Dos Santos Junior, MB, 2020) |
| " To obtain a complete inhibition of the effector limb activation, the advised dosage must be respected." | 1.40 | Eculizumab in anti-factor h antibodies associated with atypical hemolytic uremic syndrome. ( Adams, B; Corazza, F; Dahan, K; Davin, JC; Diamante Chiodini, B; Ismaili, K; Khaldi, K, 2014) |
| "Carnitine is a vital biologic substance facilitating fatty acids transport into mitochondria for ATP production." | 1.36 | Pharmacological preconditioning with L-carnitine: relevance to myocardial hemodynamic function and glycogen and lactate content. ( Garjani, A; Ghorbani-Haghjo, A; Javidnia, A; Mohammadi, S; Najafi, M, 2010) |
| "Acute cardiogenic shock or cardiac arrest (CS/CA) before cardiopulmonary bypass (CPB) installation are life-threatening events in acute coronary syndromes." | 1.35 | Continuous coronary sinus perfusion reverses ongoing myocardial damage in acute ischemia. ( Costanzo, FS; Cristodoro, L; Onorati, F; Renzulli, A; Santarpino, G; Scalas, C, 2009) |
| "Glycerol was significantly higher in the left myocardium (146 +/- 67 vs." | 1.34 | Myocardial metabolic monitoring with the microdialysis technique during and after open heart surgery. ( Bahlmann, L; Hübner, N; Klaus, S; Mantovani, V; Pöling, J; Rees, W; Warnecke, H, 2007) |
| "For glycerol, there was a further increase at reperfusion." | 1.33 | Myocardial glycerol release, arrhythmias and hemodynamic instability during regional ischemia-reperfusion in an open chest pig model. ( Algotsson, L; Liao, Q; Metzsch, C; Steen, S, 2006) |
| "Recognition of myocardial ischemia is critical both for the diagnosis of coronary artery disease and the selection and evaluation of therapy." | 1.33 | Metabolomic identification of novel biomarkers of myocardial ischemia. ( Berriz, GF; Gerszten, RE; Heller, E; Liu, E; McCarroll, R; Morrow, DA; Roth, FP; Sabatine, MS; Wiegand, R, 2005) |
| "Niacin, known to lower cytosolic NADH/NAD+ ratio independent of the aldose reductase pathway inhibition, also blocked JAK2 and STAT5 activation." | 1.33 | Aldose reductase pathway mediates JAK-STAT signaling: a novel axis in myocardial ischemic injury. ( Hwang, YC; Kaneko, M; Marrero, MB; Ramasamy, R; Redd, H; Shaw, S, 2005) |
| "Early detection of myocardial ischemia is of major importance in critical-care medicine." | 1.31 | An ultrafiltration catheter for monitoring of venous lactate and glucose around myocardial ischemia. ( Hoekstra, A; Korf, J; Tiessen, RG; Tio, RA; Venema, K, 2001) |
| "Cardiac dysfunction after brain death has been documented, but its mechanisms remain unclear." | 1.31 | Evidence of functional myocardial ischemia associated with myocardial dysfunction in brain-dead pigs. ( de Talancé, N; Devaux, Y; Grosjean, S; Mairose, P; Mertes, PM; Seguin, C; Siaghy, EM; Ungureanu-Longrois, D; Zannad, F, 2001) |
| " This study addresses the essential role of dosage in studies using C1-INH." | 1.31 | Application of C1-esterase inhibitor during reperfusion of ischemic myocardium: dose-related beneficial versus detrimental effects. ( Berg, O; Bhakdi, S; Bierbach, B; Darius, H; Götze, O; Hafner, G; Heimann, A; Horstick, G; Horstick, M; Kempski, O; Loos, M; Meyer, J; Petersen, S, 2001) |
| "When myocardial ischemia was simulated by a 60% reduction in coronary blood flow, the model generated myocardial concentrations, uptakes, and fluxes that were consistent with experimental data from in vivo pig studies." | 1.31 | Mechanistic model of myocardial energy metabolism under normal and ischemic conditions. ( Cabrera, ME; Saidel, GM; Salem, JE; Stanley, WC, 2002) |
| "Glycerol was progressively released during prolonged ischemia." | 1.31 | Monitoring of porcine myocardial ischemia and reperfusion by intravasal microdialysis. ( Bäckström, T; Franco-Cereceda, A; Liska, J; Lockowandt, U; Sylven, C, 2002) |
| "In conclusion, 12 weeks of streptozotocin diabetes in swine caused a significant decrease in myocardial GLUT4 protein and a decrease in myocardial glucose uptake during ischemia." | 1.30 | Decreased myocardial glucose uptake during ischemia in diabetic swine. ( Hacker, TA; Hall, JL; Hernandez, LA; Stanley, WC; Whitesell, LF, 1997) |
| "Carnitine kinetics were investigated in 28 normotensive patients with significant left coronary artery disease, during and after incremental atrial pacing." | 1.30 | Acute myocardial ischaemia induces cardiac carnitine release in man. ( Bartels, GL; Remme, WJ; Scholte, HR, 1997) |
| "Glycogen degradation was not increased by adenosine receptor blockade during ischaemia." | 1.30 | Adenosine receptor blockade enhance glycolysis in hypoperfused guinea-pig myocardium. ( Downey, HF; Gao, ZP; He, MX; Mallet, RT; Sun, J, 1997) |
| "Acute maximal stress, such as after cardiac arrest, is associated with an increase in the density of beta 2-adrenergic receptors on mononuclear leukocytes derived from patients after successful cardiopulmonary resuscitation." | 1.30 | Regulation of beta 2-adrenergic receptors on mononuclear leukocytes in patients with acute ischemic heart disease. ( Anhäupl, T; Georgieff, M; Lindner, KH; Lurie, KG; Prengel, AW; Trunk, E, 1997) |
| "Trimetazidine has an anti-ischemic effect in angina pectoris." | 1.30 | Trimetazidine-induced enhancement of myocardial glucose utilization in normal and ischemic myocardial tissue: an evaluation by positron emission tomography. ( Buxton, DB; Coyle, KB; Hansen, HW; Mody, FV; Mohiuddin, IH; Schelbert, HR; Singh, BN; Sumida, R, 1998) |
| "Ectasias were defined as luminal dilation of 1." | 1.30 | Exercise-induced myocardial ischemia in isolated coronary artery ectasias and aneurysms ("dilated coronopathy"). ( Herrmann, G; Krüger, D; Sheikhzadeh, A; Simon, R; Stierle, U, 1999) |
| "Adenosine and PIA treatments did not significantly affect myocardial acidosis during ischaemia." | 1.29 | Attenuation of postischaemic dysfunction by ischaemic preconditioning is not mediated by adenosine in the isolated rat heart. ( Asimakis, GK; Conti, VR; Inners-McBride, K, 1993) |
| "Glycogen depletion by anoxia or glucagon before ischemia impaired recovery." | 1.29 | Metabolic recovery of isolated working rat heart after brief global ischemia. ( Goodwin, GW; Taegtmeyer, H, 1994) |
| "3." | 1.29 | Chronic gliclazide treatment affects basal and post-ischemic cardiac function in diabetic rats. ( Mimura, G; Murakami, K; Nagamine, F; Oshiro, K; Shimabukuro, M, 1994) |
| "Adenosine appeared to be a more sensitive marker of early ischaemia than lactate, although interestingly, adenosine levels had decreased already after 15 min, most probably due to intracellular accumulation of protons and Pi." | 1.29 | Continuous monitoring of energy metabolites using microdialysis during myocardial ischaemia in the pig. ( Maripu, E; Nilsson, S; Ronquist, G; Waldenström, A; Wikström, G, 1995) |
| "Captopril (23." | 1.29 | Captopril cardioplegia on myocardial protection in the hypertrophied rat hearts. ( Xu, SC; Zhang, YH, 1994) |
| "Myocardial hibernation is an adaptive phenomenon occurring in patients with a history of acute ischemia followed by prolonged hypoperfusion." | 1.29 | Metabolic adaptation during a sequence of no-flow and low-flow ischemia. A possible trigger for hibernation. ( Bernocchi, P; Cargnoni, A; Ceconi, C; Curello, S; Ferrari, R; Pasini, E; Ruigrok, TJ, 1996) |
| "Pretreatment with deferoxamine (10 mg/kg, n = 7) or dimethylthiourea (10 mg/kg, n = 6) decreased net production of HO." | 1.29 | Hydroxyl radical production during myocardial ischemia and reperfusion in cats. ( Fu, LW; Halliwell, B; Longhurst, JC; O'Neill, CA, 1996) |
| "During hypoxemia, pressure dropped initially, as observed during ischemia." | 1.29 | Dynamics of myocardial adaptation to low-flow ischemia and hypoxemia. ( Allibardi, S; de Jong, JW; Merati, G; Monti, LD; Samaja, M, 1996) |
| "Dilazep was given 5 min before starting ischemia until the end of ischemia." | 1.29 | A study on dilazep: I. Mechanism of anti-ischemic action of dilazep is not coronary vasodilation but decreased cardiac mechanical function in the isolated, working rat heart. ( Abiko, Y; Hashizume, H; Hoque, AN; Hoque, N, 1995) |
| "When hearts could adjust their HR, hypoxemia demanded more energy than ischemia (p < 0." | 1.29 | Effects of energy demand in ischemic and in hypoxemic isolated rat hearts. ( Allibardi, S; Casalini, S; Corno, A; Samaja, M, 1994) |
| "Pretreatment with diazoxide (10 mg." | 1.29 | Effects of diazoxide on norepinephrine-induced vasocontraction and ischemic myocardium in rats. ( Ichihara, K; Nakai, T, 1994) |
| "Treatment with BW A1433U reduced TOIC [8." | 1.29 | Adenosine increases lactate release and delays onset of contracture during global low flow ischaemia. ( Lasley, RD; Mentzer, RM, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.30) | 18.7374 |
| 1990's | 176 (53.50) | 18.2507 |
| 2000's | 122 (37.08) | 29.6817 |
| 2010's | 28 (8.51) | 24.3611 |
| 2020's | 2 (0.61) | 2.80 |
| Authors | Studies |
|---|---|
| Khalil, MA | 1 |
| El Tahan, MR | 1 |
| Khidr, AM | 1 |
| Fallatah, S | 1 |
| Abohamar, AD | 1 |
| Amer, MM | 1 |
| Makhdom, F | 1 |
| El Ghoneimy, Y | 1 |
| Al Bassam, B | 1 |
| Alghamdi, T | 1 |
| Abdulfattah, D | 1 |
| da Silva, TOB | 1 |
| de Moura Vidal, LW | 1 |
| Cabral, PGA | 1 |
| da Mota Costa, MR | 1 |
| Cadena, SMR | 1 |
| Dos Santos Junior, MB | 1 |
| Antunes, F | 1 |
| de Abreu Oliveira, AL | 1 |
| Hoshino, Y | 1 |
| Kinoshita, O | 1 |
| Ono, M | 1 |
| Boening, A | 1 |
| Assling-Simon, L | 1 |
| Heep, M | 1 |
| Boengler, K | 1 |
| Niemann, B | 1 |
| Grieshaber, P | 1 |
| Formiga, FR | 2 |
| Garbayo, E | 1 |
| Díaz-Herráez, P | 1 |
| Abizanda, G | 1 |
| Simón-Yarza, T | 3 |
| Tamayo, E | 2 |
| Prósper, F | 3 |
| Blanco-Prieto, MJ | 3 |
| Kukes, VG | 1 |
| Zhernakova, NI | 1 |
| Gorbach, TV | 1 |
| Romashchenko, OV | 1 |
| Rumbesht, VV | 1 |
| Benavides, C | 1 |
| Lana, H | 1 |
| Grama, CN | 1 |
| Ortiz-de-Solorzano, C | 1 |
| Kumar, MN | 1 |
| Favaretto, E | 1 |
| Tarantini, G | 1 |
| Ikonomidis, I | 1 |
| Makavos, G | 1 |
| Nikitas, N | 1 |
| Paraskevaidis, I | 1 |
| Diamantakis, A | 1 |
| Kopterides, P | 1 |
| Theodorakopoulou, M | 1 |
| Parissis, J | 1 |
| Lekakis, J | 1 |
| Armaganidis, A | 1 |
| Dimopoulou, I | 1 |
| Diamante Chiodini, B | 1 |
| Davin, JC | 1 |
| Corazza, F | 1 |
| Khaldi, K | 1 |
| Dahan, K | 1 |
| Ismaili, K | 1 |
| Adams, B | 1 |
| Shi, X | 1 |
| Lin, X | 1 |
| Yao, C | 1 |
| Shen, L | 1 |
| Feng, Y | 1 |
| Bul'on, VV | 1 |
| Krylova, IB | 1 |
| Selina, EN | 1 |
| Rodionova, OM | 1 |
| Evdokimova, NR | 1 |
| Sapronov, NS | 1 |
| Mironova, GD | 1 |
| Rossi, A | 1 |
| Heffels, KH | 1 |
| Groll, J | 1 |
| Almashhadany, A | 1 |
| Alghamdi, OA | 1 |
| Van der Touw, T | 1 |
| Jones, GL | 1 |
| King, N | 1 |
| Azam, MA | 1 |
| Wagg, CS | 1 |
| Massé, S | 1 |
| Farid, T | 1 |
| Lai, PF | 1 |
| Kusha, M | 1 |
| Asta, J | 1 |
| Jaimes, R | 1 |
| Kuzmiak-Glancy, S | 1 |
| Kay, MW | 1 |
| Lopaschuk, GD | 6 |
| Nanthakumar, K | 1 |
| Wilder, CD | 1 |
| Masoud, R | 1 |
| Yazar, D | 1 |
| O'Brien, BA | 1 |
| Eykyn, TR | 1 |
| Curtis, MJ | 1 |
| Nakano, Y | 1 |
| Matoba, T | 1 |
| Tokutome, M | 1 |
| Funamoto, D | 1 |
| Katsuki, S | 1 |
| Ikeda, G | 1 |
| Nagaoka, K | 1 |
| Ishikita, A | 1 |
| Nakano, K | 1 |
| Koga, J | 1 |
| Sunagawa, K | 2 |
| Egashira, K | 2 |
| Sugiura, Y | 1 |
| Katsumata, Y | 1 |
| Sano, M | 1 |
| Honda, K | 1 |
| Kajimura, M | 1 |
| Fukuda, K | 2 |
| Suematsu, M | 1 |
| Koizumi, K | 1 |
| Shin, H | 1 |
| Matayoshi, T | 1 |
| Yozu, R | 1 |
| Kim, JH | 1 |
| Choi, JH | 1 |
| Lee, HK | 1 |
| Bae, WH | 1 |
| Chun, KJ | 1 |
| Kim, YS | 1 |
| Lee, SK | 1 |
| Kim, HH | 1 |
| Hong, TJ | 1 |
| Shin, YW | 1 |
| Schroeder, MA | 1 |
| Atherton, HJ | 1 |
| Ball, DR | 1 |
| Cole, MA | 1 |
| Heather, LC | 1 |
| Griffin, JL | 1 |
| Clarke, K | 4 |
| Radda, GK | 4 |
| Tyler, DJ | 1 |
| Mantovani, V | 4 |
| Kennergren, C | 2 |
| Bugge, M | 1 |
| Sala, A | 1 |
| Lönnroth, P | 2 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Gastric Bypass-induced Weight Loss on Myocardial Structure, Function and Metabolism[NCT00841009] | 18 participants (Actual) | Observational | 2005-07-31 | Completed | |||
| Sex and Obesity Effects on Myocardial Blood Flow and Metabolism[NCT00776035] | 10 participants (Anticipated) | Observational | 2008-01-31 | Active, not recruiting | |||
| Outcome of Esmolol Potassium Cardioplegia Compared to Potassium Cardioplegia in Patients With Solitary Valvular Disease; Randomized Controlled Study[NCT04306913] | 80 participants (Anticipated) | Interventional | 2020-04-30 | Not yet recruiting | |||
| Ischemic Preconditioning for Prevention of Contrast Nephropathy in The Emergency Department: Randomised, Double Blind Clinical Trial[NCT03238391] | 350 participants (Anticipated) | Interventional | 2017-08-15 | Not yet recruiting | |||
| Effect of Remote Ischemic Preconditioning on Pulmonary Injury in Cardic Surgery[NCT03016182] | 60 participants (Anticipated) | Interventional | 2017-02-07 | Recruiting | |||
| A Clinical Study Investigating Ischemic Preconditioning in Type II Diabetic Patients Undergoing Coronary Artery Bypass Graft Surgery.[NCT00397163] | Phase 1 | 200 participants (Anticipated) | Interventional | 2010-12-31 | Completed | ||
| The Effect of Hyperinsulinemic Glucose Control on Outcomes Following Cardiac Surgery[NCT00524472] | 1,439 participants (Actual) | Interventional | 2007-07-31 | Completed | |||
| Attenuation of Myocardial Dysfunction by N-Acetylcysteine in Infants Undergoing Arterial Switch Procedure[NCT00374088] | Phase 2 | 21 participants (Actual) | Interventional | 2005-02-28 | Completed | ||
| A Randomised Controlled Trial of the Effect of Remote Ischaemic Conditioning on Coronary Endothelial Function in Patients With Angina.[NCT02666235] | Phase 2 | 60 participants (Actual) | Interventional | 2011-07-31 | Completed | ||
| Non Invasive and Non-Contact Dual-modal Imaging Of Tissue Oxygenation and Vascular Reactivity Dynamic Imaging Of Tissue Metabolism and Vascular Function.[NCT01573390] | 0 participants (Actual) | Observational | Withdrawn (stopped due to most of the study team left the institution prior to study initiation) | ||||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
a composite of minor postoperative complications, which includes: a) prolonged mechanical ventilation, b) low cardiac index, c) acute kidney injury, d) prolonged hospitalization, and 3) all-cause hospital readmission within 30 days. (NCT00524472)
Timeframe: within 30 days after surgery
| Intervention | Participants (Count of Participants) |
|---|---|
| Hyperinsulinemic-normoglycemic Clamp | 200 |
| Insulin at the Standard of Care Levels | 237 |
All-cause mortality identified during one-year follow-up. (NCT00524472)
Timeframe: one year post operative
| Intervention | Participants (Count of Participants) |
|---|---|
| Hyperinsulinemic-normoglycemic Clamp | 32 |
| Insulin at the Standard of Care Levels | 22 |
"a composite (any versus none) of the following major postoperative complications occurring:~all-cause postoperative mortality~failure to wean from cardiopulmonary bypass or postoperative low cardiac index requiring mechanical circulatory support with intraaortic balloon counterpulsation, ventricular assist device, and/or extracorporeal mechanical oxygenation~serious postoperative infection~acute postoperative kidney injury requiring renal replacement therapy;~new postoperative focal or global neurologic deficit." (NCT00524472)
Timeframe: within 30 days post surgery
| Intervention | Participants (Count of Participants) |
|---|---|
| Hyperinsulinemic-normoglycemic Clamp | 46 |
| Insulin at the Standard of Care Levels | 82 |
Days from date of surgery to hospital discharge (NCT00524472)
Timeframe: starting post operative day one to discharge from hospital, on an average of 8 days
| Intervention | days (Median) |
|---|---|
| Hyperinsulinemic-normoglycemic Clamp | 8 |
| Insulin at the Standard of Care Levels | 8 |
Hours from date of surgery to discharge from intensive care unit (NCT00524472)
Timeframe: ICU stay hours during hospital stay after surgery, on average of 25 hours
| Intervention | hours (Median) |
|---|---|
| Hyperinsulinemic-normoglycemic Clamp | 25 |
| Insulin at the Standard of Care Levels | 27 |
Evidence suggests that maintaining intra-operative normoglycemia during cardiac surgery while providing exogenous glucose and high-dose insulin may decrease post-operative morbidity or mortality. Using a randomized, controlled design, we propose to test the primary hypothesis that normalization of blood glucose using a hyperinsulinemic-normoglycemic clamp technique reduces the risk of a composite of serious adverse outcomes in patients undergoing cardiac surgery (NCT00524472)
Timeframe: 15 - 30 days post operative
| Intervention | Participants (Count of Participants) |
|---|---|
| Hyperinsulinemic-normoglycemic Clamp | 209 |
| Insulin at the Standard of Care Levels | 235 |
Maximum serum creatinine over first 3 days postoperative. (NCT00374088)
Timeframe: 72 hours
| Intervention | mg/dL (Mean) |
|---|---|
| Placebo | 0.99 |
| N-acetylcysteine | 0.74 |
Serial cardiac output was measured by thermodilution. The outcome of maximum decline in indexed cardiac output from 1 hour postoperative to lowest output within 24 hours postoperative was then calculated and compared between NAC and placebo groups. (NCT00374088)
Timeframe: 24 hours
| Intervention | L/min/m2 (Mean) |
|---|---|
| Placebo | 0.68 |
| N-acetylcysteine | 0.29 |
Total urine output over the first 24 hours postoperative (NCT00374088)
Timeframe: 24 hours
| Intervention | mL (Mean) |
|---|---|
| Placebo | 96 |
| N-acetylcysteine | 176 |
11 reviews available for lactic acid and Myocardial Ischemia
| Article | Year |
|---|---|
Thymosin β4 sustained release from poly(lactide-co-glycolide) microspheres: synthesis and implications for treatment of myocardial ischemia.
Topics: Humans; Lactic Acid; Microspheres; Myocardial Ischemia; Polyglycolic Acid; Polylactic Acid-Polyglyco | 2012 |
ASIC3: a lactic acid sensor for cardiac pain.
Topics: Acid Sensing Ion Channels; Angina Pectoris; Animals; Coronary Artery Disease; Heart; Humans; Lactic | 2001 |
Myocardial preconditioning: a model or a phenomenon?
Topics: Adenosine Triphosphate; Animals; Heat-Shock Response; Humans; Lactates; Lactic Acid; Myocardial Isch | 1995 |
Myocardial metabolic markers of total ischemia in vitro.
Topics: Animals; Biomarkers; Dogs; Female; Lactates; Lactic Acid; Male; Myocardial Ischemia; Phosphates; Suc | 1994 |
Potassium loss during myocardial ischaemia and hypoxia: does lactate efflux play a role?
Topics: Biological Transport; Cell Membrane; Humans; Hypoxia; Lactates; Lactic Acid; Myocardial Ischemia; My | 1994 |
Lactate transport in heart in relation to myocardial ischemia.
Topics: Animals; Biological Transport, Active; Humans; Lactic Acid; Myocardial Ischemia; Myocardium; Substra | 1997 |
Myocardial ischemia in generalized coronary artery-left ventricular microfistulae.
Topics: Aged; Cardiac Catheterization; Cardiomyopathies; Coronary Angiography; Coronary Disease; Echocardiog | 1998 |
[Metabolic aspects of myocardial ischemia].
Topics: Adenosine; Animals; Blood Glucose; Coronary Circulation; Energy Metabolism; HSP70 Heat-Shock Protein | 1998 |
Chemical mediators of pain due to tissue damage and ischemia.
Topics: Acetylcholine; Acid Sensing Ion Channels; Adenosine; Adenosine Triphosphate; Afferent Pathways; Anim | 2000 |
Characterization of "hibernating" and "stunned" myocardium with focus on the use of calcium antagonists in "stunned" myocardium.
Topics: Calcium; Calcium Channel Blockers; Coronary Circulation; Humans; Lactates; Lactic Acid; Myocardial C | 1992 |
Interrelationship between lactate and cardiac fatty acid metabolism.
Topics: Animals; Carbohydrate Metabolism; Dogs; Energy Metabolism; Fatty Acids; Heart; Homeostasis; Humans; | 1992 |
23 trials available for lactic acid and Myocardial Ischemia
| Article | Year |
|---|---|
Effects of norepinephrine infusion during cardiopulmonary bypass on perioperative changes in lactic acid level (Norcal).
Topics: Cardiopulmonary Bypass; Humans; Hyperlactatemia; Hypotension; Lactic Acid; Myocardial Ischemia; Nore | 2023 |
Myocardial metabolism assessed by microdialysis: a prospective randomized study in on- and off-pump coronary bypass surgery.
Topics: Aged; Biomarkers; Coronary Artery Bypass, Off-Pump; Energy Metabolism; Female; Glucose; Glycerol; Hu | 2010 |
Fluorouracil induces myocardial ischemia with increases of plasma brain natriuretic peptide and lactic acid but without dysfunction of left ventricle.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherap | 2010 |
Predictors of allograft ischemic injury in clinical heart transplantation.
Topics: Adolescent; Adult; Amino Acids; Biomarkers; Cardioplegic Solutions; Creatine Kinase; Creatine Kinase | 2002 |
Differential role of K(ATP) channels activated by conjugated estrogens in the regulation of myocardial and coronary protective effects.
Topics: Adenosine Triphosphate; Angioplasty, Balloon, Coronary; Cardiotonic Agents; Chest Pain; Coronary Dis | 2003 |
Efficacy of esmolol as a myocardial protective agent during continuous retrograde blood cardioplegia.
Topics: Adrenergic beta-Antagonists; Aged; Aortic Valve Stenosis; Cardioplegic Solutions; Cardiopulmonary By | 2003 |
Markers of myocardial ischemia in the evaluation of the effect of left anterior descending coronary artery lesion and collateral circulation on myocardial injury in 1-vessel off-pump coronary bypass surgery.
Topics: Adult; Aged; Biomarkers; Cardiac Output, Low; Collateral Circulation; Coronary Artery Bypass; Corona | 2003 |
Pyruvate-enhanced cardioprotection during surgery with cardiopulmonary bypass.
Topics: Aged; Cardioplegic Solutions; Cardiopulmonary Bypass; Cardiotonic Agents; Catecholamines; Coronary A | 2003 |
Effect of ischaemic preconditioning on regional release of inflammatory markers.
Topics: Adult; Angioplasty, Balloon, Coronary; Biomarkers; Blood Glucose; CD40 Ligand; Electrocardiography; | 2005 |
Does poor oxygenation during one-lung ventilation impair aerobic myocardial metabolism in patients with symptomatic coronary artery disease?
Topics: Aged; Anaerobic Threshold; Cardiopulmonary Bypass; Coronary Artery Bypass; Coronary Artery Disease; | 2007 |
Contributions of myocardial ischemia and heart rate to ST segment changes in patients with or without coronary artery disease.
Topics: Adult; Aged; Arrhythmias, Cardiac; Blood Pressure; Cardiac Pacing, Artificial; Coronary Artery Disea | 2008 |
Myocardial protection during elective coronary artery bypass grafting using high-dose insulin therapy.
Topics: Aged; Cardiopulmonary Bypass; Coronary Artery Bypass; Elective Surgical Procedures; Female; Glucose; | 2007 |
Alpha-ketoglutarate for myocardial protection in heart surgery.
Topics: Aged; Cardioplegic Solutions; Cardiopulmonary Bypass; Coronary Artery Bypass; Coronary Disease; Crea | 1995 |
[Anti-ischemia effects of gallopamil and esmolol in an intra-individual comparison in patients with coronary heart disease].
Topics: Adrenergic beta-Antagonists; Aged; Aldosterone; Atrial Natriuretic Factor; Coronary Angiography; Cor | 1994 |
Effects of enoximone and R 80122, a new selective phosphodiesterase III inhibitor, on hemodynamics and myocardial energetics in patients with ischemic heart disease.
Topics: Adult; Aged; Cardiotonic Agents; Catecholamines; Coronary Circulation; Enoximone; Heart; Hemodynamic | 1994 |
Which techniques of cardioplegia prevent ischemia?
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Blood Flow Velocity; Blood Transfusion, Autologous; | 1993 |
Safety of low-dose intraoperative bicarbonate therapy: a prospective, double-blind, randomized study. The Study of Perioperative Ischemia (SPI) Research Group.
Topics: Acidosis, Lactic; Aged; Bicarbonates; Blood Gas Analysis; Blood Glucose; Calcium; Cardiac Output; Co | 1993 |
Effect of acadesine on myocardial ischaemia in patients with coronary artery disease.
Topics: Adult; Aged; Aminoimidazole Carboxamide; Cardiac Catheterization; Coronary Disease; Female; Hemodyna | 1997 |
Comparison of coronary hemodynamics during infusions of dobutamine and adenosine in patients with angina pectoris.
Topics: Adenosine; Aged; Angina Pectoris; Blood Pressure; Chest Pain; Dobutamine; Electrocardiography; Femal | 1998 |
Effect of non-insulin-dependent diabetes mellitus on myocardial insulin responsiveness in patients with ischemic heart disease.
Topics: Angiography; Blood Glucose; Coronary Circulation; Diabetes Mellitus, Type 2; Fasting; Hemodynamics; | 2001 |
Effects of prolonged strenuous exercise on plasma levels of atrial natriuretic peptide and brain natriuretic peptide in healthy men.
Topics: Adult; Atrial Natriuretic Factor; Biomarkers; Epinephrine; Exercise; Hematocrit; Hemoglobins; Humans | 2001 |
The response of the myocardial metabolism to atrial pacing in patients with coronary slow flow.
Topics: Angina Pectoris; Atrial Function; Biomarkers; Blood Flow Velocity; Cardiac Pacing, Artificial; Coron | 2001 |
Nicorandil, a hybrid between nitrate and ATP-sensitive potassium channel opener, preconditions human heart to ischemia during percutaneous transluminal coronary angioplasty.
Topics: Aged; Aged, 80 and over; Angina Pectoris; Angioplasty, Balloon, Coronary; Electrocardiography; Femal | 2001 |
295 other studies available for lactic acid and Myocardial Ischemia
| Article | Year |
|---|---|
Interventionist videothermometry: a new model of cardiac ischemia evaluation.
Topics: Animals; Bicarbonates; Female; Heart; Heart Arrest; Lactic Acid; Myocardial Ischemia; Myocardium; Ra | 2020 |
The Incidence, Risk Factors, and Outcomes of Hyperlactatemia after Heart Transplantation.
Topics: Adult; Female; Follow-Up Studies; Heart Transplantation; Humans; Hyperlactatemia; Incidence; Japan; | 2018 |
Buckberg's blood cardioplegia for protection of adult and senile myocardium in a rat in vitro model of acute myocardial infarction.
Topics: Analysis of Variance; Animals; Aorta; Cardioplegic Solutions; Constriction; Coronary Vessels; Diseas | 2018 |
Biodegradation and heart retention of polymeric microparticles in a rat model of myocardial ischemia.
Topics: Animals; Disease Models, Animal; Drug Carriers; Drug Delivery Systems; Emulsions; Feasibility Studie | 2013 |
[Efficiency of trimetazidine treatment of experimental ischemic heart disease in age aspect].
Topics: Adenosine Triphosphate; Age Factors; Animals; Cell Membrane; Citrate (si)-Synthase; Disease Models, | 2013 |
Functional benefits of PLGA particulates carrying VEGF and CoQ10 in an animal of myocardial ischemia.
Topics: Animals; Cell Proliferation; Coronary Vessels; Disease Models, Animal; Female; Human Umbilical Vein | 2013 |
Acidic postconditioning in ST-elevation myocardial infarction patients.
Topics: Angioplasty, Balloon, Coronary; Female; Humans; Ischemic Preconditioning, Myocardial; Isotonic Solut | 2013 |
Coronary flow reserve is associated with tissue ischemia and is an additive predictor of intensive care unit mortality to traditional risk scores in septic shock.
Topics: Acidosis; Aged; APACHE; Blood Glucose; Coronary Circulation; Echocardiography, Doppler; Echocardiogr | 2014 |
Eculizumab in anti-factor h antibodies associated with atypical hemolytic uremic syndrome.
Topics: Antibodies, Monoclonal, Humanized; Autoantibodies; Brain; Brain Ischemia; Child; Complement Factor H | 2014 |
Injectable long-acting in situ forming systems for Radix Ophiopogonis polysaccharide.
Topics: Animals; Drug Carriers; Humans; Hydrogels; Hydrophobic and Hydrophilic Interactions; Kinetics; Lacti | 2015 |
Antiarrhythmic effect of uridine and uridine-5'-monophosphate in acute myocardial ischemia.
Topics: Animals; Arrhythmias, Cardiac; Coronary Vessels; Energy Metabolism; Glycogen; Lactic Acid; Ligation; | 2014 |
Polymeric electrospun scaffolds: neuregulin encapsulation and biocompatibility studies in a model of myocardial ischemia.
Topics: Animals; Biocompatible Materials; Cell Polarity; Disease Models, Animal; Female; Lactic Acid; Macrop | 2015 |
L-Glycyl-L-glutamine provides the isolated and perfused young and middle-aged rat heart protection against ischaemia-reperfusion injury.
Topics: Age Factors; Animals; Dipeptides; Isolated Heart Preparation; Lactic Acid; Lipid Peroxidation; Male; | 2015 |
Feeding the fibrillating heart: Dichloroacetate improves cardiac contractile dysfunction following VF.
Topics: Animals; Dichloroacetic Acid; Heart; Lactic Acid; Male; Myocardial Contraction; Myocardial Ischemia; | 2015 |
Contractile function assessment by intraventricular balloon alters the ability of regional ischaemia to evoke ventricular fibrillation.
Topics: Animals; Cardiac Catheters; Electrocardiography; Lactic Acid; Magnetic Resonance Spectroscopy; Male; | 2016 |
Nanoparticle-Mediated Delivery of Irbesartan Induces Cardioprotection from Myocardial Ischemia-Reperfusion Injury by Antagonizing Monocyte-Mediated Inflammation.
Topics: Administration, Intravenous; Animals; Biphenyl Compounds; Cardiotonic Agents; Disease Models, Animal | 2016 |
Visualization of in vivo metabolic flows reveals accelerated utilization of glucose and lactate in penumbra of ischemic heart.
Topics: Animals; Carbon Isotopes; Glucose; Glutamic Acid; Lactic Acid; Male; Metabolic Networks and Pathways | 2016 |
Comparison of active and passive coronary perfusion in off-pump coronary artery bypass grafting.
Topics: Animals; Coronary Artery Bypass, Off-Pump; Coronary Circulation; Coronary Stenosis; Disease Models, | 2008 |
Ischemia-modified albumin (IMA) is not useful for detecting myocardial ischemia during symptom-limited exercise stress tests.
Topics: Aged; Albumins; Chest Pain; Electrocardiography; Exercise Test; Female; Humans; Lactic Acid; Male; M | 2008 |
Real-time assessment of Krebs cycle metabolism using hyperpolarized 13C magnetic resonance spectroscopy.
Topics: Acetylcarnitine; Animals; Carbon Isotopes; Citric Acid; Citric Acid Cycle; Energy Metabolism; Glutam | 2009 |
Reductions in mitochondrial O(2) consumption and preservation of high-energy phosphate levels after simulated ischemia in chronic hibernating myocardium.
Topics: Adenosine Triphosphate; Animals; Chronic Disease; Coronary Circulation; Coronary Occlusion; Coronary | 2009 |
Metabolic responses in ischemic myocardium after inhalation of carbon monoxide.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Blood Pressure; Carbon Monoxide; Carboxyhemo | 2009 |
Levosimendan cardioprotection in acutely beta-1 adrenergic receptor blocked open chest pigs.
Topics: Adrenergic beta-Antagonists; Animals; Cardiotonic Agents; Clinical Protocols; Female; Glucose; Glyce | 2010 |
Ischaemic preconditioning is related to decreasing levels of extracellular adenosine that may be metabolically useful in the at-risk myocardium: an experimental study in the pig.
Topics: 5'-Nucleotidase; Adenosine; Adenosine Triphosphate; Animals; Female; Humans; Ischemic Preconditionin | 2010 |
Intravascular ultrasound study and evidence of pathological coronary flow reserve in patients with isolated coronary artery aneurysms.
Topics: Aged; Blood Flow Velocity; Case-Control Studies; Coronary Aneurysm; Coronary Angiography; Coronary C | 2010 |
Continuous coronary sinus perfusion reverses ongoing myocardial damage in acute ischemia.
Topics: Acute Coronary Syndrome; Aged; Biomarkers; Cardiopulmonary Bypass; Cardiotonic Agents; Coronary Arte | 2009 |
Glutamate release predicts ongoing myocardial ischemia of rat hearts.
Topics: Animals; Aquaporins; Cell Nucleus; Gene Expression Regulation; Glucose; Glutamic Acid; Glycerol; Lac | 2010 |
Metabolic monitoring of postischemic myocardium during intermittent warm-blood cardioplegic administration.
Topics: Adult; Aged; Blood Glucose; Cardioplegic Solutions; Coronary Artery Bypass; Elective Surgical Proced | 2010 |
Pharmacological preconditioning with L-carnitine: relevance to myocardial hemodynamic function and glycogen and lactate content.
Topics: Adenosine Triphosphate; Animals; Carnitine; Glycogen; Hemodynamics; Ischemic Preconditioning, Myocar | 2010 |
Ghrelin improves disturbed myocardial energy metabolism in rats with heart failure induced by isoproterenol.
Topics: Animals; Blood Glucose; Blotting, Western; Body Weight; Eating; Echocardiography; Energy Metabolism; | 2010 |
Ischaemic pre-conditioning means an increased adenosine metabolism with decreased glycolytic flow in ischaemic pig myocardium.
Topics: Adenosine; Animals; Blood Glucose; Body Temperature; Energy Metabolism; Female; Glycerol; Glycogen; | 2010 |
Detection of myocardial ischaemia using surface microdialysis on the beating heart.
Topics: Animals; Biomarkers; Disease Models, Animal; Energy Metabolism; Female; Glucose; Glycerol; Lactic Ac | 2011 |
Sheng-Mai-San is protective against post-ischemic myocardial dysfunction in rats through its opening of the mitochondrial KATP channels.
Topics: Adenosine Triphosphate; Animals; Cardiomyopathies; Cardiotonic Agents; Drug Combinations; Drugs, Chi | 2002 |
Measurement of extracellular pH, K(+), and lactate in ischemic heart.
Topics: Animals; Biosensing Techniques; Buffers; Electrochemistry; Extracellular Space; Hydrogen-Ion Concent | 2002 |
Myocardial interstitial glucose and lactate before, during, and after cardioplegic heart arrest.
Topics: Adult; Aged; Cardiopulmonary Bypass; Female; Glucose; Heart Arrest, Induced; Humans; Hypothermia, In | 2003 |
Heat acclimation-induced elevated glycogen, glycolysis, and low thyroxine improve heart ischemic tolerance.
Topics: Acclimatization; Animals; Carbon Isotopes; Glucose; Glycogen; Glycolysis; Hot Temperature; Hypothyro | 2002 |
Regional variations in myocardial tissue oxygenation mapped by near-infrared spectroscopic imaging.
Topics: Animals; Blood Glucose; Hemoglobins; Lactic Acid; Myocardial Ischemia; Myocardium; Oxygen Consumptio | 2002 |
Beta-adrenergic blockade during severe ischemia.
Topics: Acebutolol; Adrenergic beta-Antagonists; Animals; Coronary Circulation; Hemodynamics; Lactic Acid; M | 2002 |
Effect of hyperglycemia and fatty acid oxidation inhibition during aerobic conditions and demand-induced ischemia.
Topics: Animals; Coronary Circulation; Disease Models, Animal; Fatty Acids, Nonesterified; Glycogen; Glycoly | 2003 |
Impact of aging on substrate metabolism by the human heart.
Topics: Adult; Aged; Aging; Blood Glucose; Fatty Acids; Female; Humans; Insulin; Lactic Acid; Male; Middle A | 2003 |
Impact of aging on substrate metabolism by the human heart.
Topics: Adult; Aged; Aging; Blood Glucose; Fatty Acids; Female; Humans; Insulin; Lactic Acid; Male; Middle A | 2003 |
Impact of aging on substrate metabolism by the human heart.
Topics: Adult; Aged; Aging; Blood Glucose; Fatty Acids; Female; Humans; Insulin; Lactic Acid; Male; Middle A | 2003 |
Impact of aging on substrate metabolism by the human heart.
Topics: Adult; Aged; Aging; Blood Glucose; Fatty Acids; Female; Humans; Insulin; Lactic Acid; Male; Middle A | 2003 |
Impairment of myocardial protection in type 2 diabetic patients.
Topics: Aged; Angioplasty, Balloon, Coronary; Blood Pressure; Chest Pain; Diabetes Mellitus, Type 2; Electro | 2003 |
Protection of ischemic myocardium in dogs using intracoronary 2,3-butanedione monoxime (BDM).
Topics: Adenosine Triphosphate; Animals; Coronary Circulation; Diacetyl; Dogs; Enzyme Inhibitors; Female; He | 2003 |
Effect of NO synthase inhibition on myocardial metabolism during moderate ischemia.
Topics: Animals; Coronary Circulation; Energy Metabolism; Enzyme Inhibitors; Fatty Acids, Nonesterified; Glu | 2003 |
Dobutamine responsiveness, PET mismatch, and lack of necrosis in low-flow ischemia: is this hibernation in the isolated rat heart?
Topics: Adrenergic beta-Agonists; Animals; Blood Pressure; Creatine Kinase; Dobutamine; Fluorodeoxyglucose F | 2003 |
Effects of nebivolol on ischemia-induced metabolic changes in dog hearts.
Topics: Adrenergic beta-Antagonists; Animals; Benzopyrans; Carbohydrate Metabolism; Dogs; Endothelium, Vascu | 2003 |
Partial inhibition of fatty acid oxidation increases regional contractile power and efficiency during demand-induced ischemia.
Topics: Animals; Blood Glucose; Carnitine O-Palmitoyltransferase; Fatty Acids; Fatty Acids, Nonesterified; G | 2003 |
Coronary hemodynamic and metabolic studies of the coronary slow flow phenomenon.
Topics: Adult; Analysis of Variance; Cardiac Catheterization; Cardiac Pacing, Artificial; Chest Pain; Corona | 2003 |
Postnatal increase in insulin-sensitive glucose transporter expression is associated with improved recovery of postischemic myocardial function.
Topics: Age Factors; Animals; Biological Transport; Biomarkers; Disease Models, Animal; Female; Glucose-6-Ph | 2003 |
Cariporide enhances lactate clearance upon reperfusion but does not alter lactate accumulation during global ischaemia.
Topics: Animals; Dose-Response Relationship, Drug; Guanidines; Guinea Pigs; In Vitro Techniques; Lactic Acid | 2003 |
Validity of the microdialysis technique for experimental in vivo studies of myocardial energy metabolism.
Topics: Adenosine; Animals; Biopsy; Energy Metabolism; Hypoxanthine; Inosine; Lactic Acid; Microdialysis; My | 2003 |
Effects of delayed preconditioning on myocardial regional contractility during repeated episodes of low-flow ischaemia in anaesthetized dogs: possible role of nitric oxide.
Topics: Animals; Cardiac Pacing, Artificial; Dogs; Female; Ischemic Preconditioning, Myocardial; Lactic Acid | 2004 |
Monitoring of water content and water distribution in ischemic hearts.
Topics: Animals; Cell Membrane; Dogs; Electric Conductivity; Electrochemistry; Extracellular Space; Hydrogen | 2003 |
Evaluation of cellular energetics by the pasteur effect in intact cardiomyoblasts and isolated perfused hearts.
Topics: Animals; Anti-Bacterial Agents; Antimycin A; Cell Line; Energy Metabolism; In Vitro Techniques; Lact | 2004 |
Effect of amino acid mixture on the isolated ischemic heart.
Topics: Adenosine Triphosphate; Administration, Oral; Amino Acids, Essential; Animals; Creatine Kinase; Diet | 2004 |
Computational studies of the effects of myocardial blood flow reductions on cardiac metabolism.
Topics: Adenosine Triphosphate; Glycogen; Glycolysis; Lactic Acid; Models, Cardiovascular; Myocardial Ischem | 2004 |
Myocardial and peripheral concentrations of beta-endorphin before and following myocardial ischemia and reperfusion during coronary angioplasty.
Topics: Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; beta-Endorphin; Blood Pressure; Coronary Di | 2004 |
Step and ramp induction of myocardial ischemia: comparison of in vivo and in silico results.
Topics: Animals; Computer Simulation; Coronary Circulation; Disease Models, Animal; Energy Metabolism; Glyco | 2004 |
Effects of ischaemia-mimetic factors on isolated rat ventricular myocytes.
Topics: Acidosis; Animals; Glucose; Heart Ventricles; Hypoxia; In Vitro Techniques; Lactic Acid; Male; Myoca | 2005 |
Aldose reductase pathway mediates JAK-STAT signaling: a novel axis in myocardial ischemic injury.
Topics: Aldehyde Reductase; Animals; Blotting, Western; Enzyme Activation; Enzyme Inhibitors; Humans; Janus | 2005 |
Inclusion of lidocaine in cardioplegic solutions provides additional myocardial protection.
Topics: Animals; Anti-Arrhythmia Agents; Cardiac Surgical Procedures; Cardioplegic Solutions; Creatine Kinas | 2004 |
Effects of KATP channel modulation on myocardial glycogen content, lactate, and amino acids in nonischemic and ischemic rat hearts.
Topics: Alanine; Amino Acids; Animals; Diazoxide; Drug Interactions; Glutamic Acid; Glyburide; Glycogen; Lac | 2005 |
Microdialysis separately monitors myocardial interstitial myoglobin during ischemia and reperfusion.
Topics: Animals; Blood Pressure; Glycerol; Heart Rate; Lactic Acid; Male; Microdialysis; Myocardial Ischemia | 2005 |
Trimetazidine normalizes postischemic function of hypertrophied rat hearts.
Topics: Adenosine Triphosphate; Animals; Cardiomegaly; Coronary Circulation; Glucose; Glycolysis; Kinetics; | 2005 |
Early pre-diabetic state alters adaptation of myocardial glucose metabolism during ischemia in rats.
Topics: Adaptation, Physiological; Animals; Diabetes Mellitus, Experimental; Fructose; Glucose; Glucose Tran | 2005 |
Malonyl-CoA decarboxylase inhibition suppresses fatty acid oxidation and reduces lactate production during demand-induced ischemia.
Topics: Animals; Blood Glucose; Carboxy-Lyases; Enzyme Inhibitors; Fatty Acids; Lactic Acid; Lipid Peroxidat | 2005 |
Lactate concentration gradient from right atrium to pulmonary artery: a commentary.
Topics: Biomarkers; Coronary Circulation; Heart Atria; Humans; Lactic Acid; Myocardial Ischemia; Oxygen; Pul | 2005 |
Regulation of lactate production at the onset of ischaemia is independent of mitochondrial NADH/NAD+: insights from in silico studies.
Topics: Animals; Aspartic Acid; Computer Simulation; Cytosol; Energy Metabolism; Glycolysis; Humans; Ischemi | 2005 |
Evidence for a significant myocardial contribution to total metabolic burden during hypothermic cardiopulmonary bypass: a study of continuously measured oxygen consumption and arterial lactate levels in pigs.
Topics: Animals; Arteries; Cardiopulmonary Bypass; Hypothermia, Induced; Kinetics; Lactic Acid; Mass Spectro | 2005 |
Metabolomic identification of novel biomarkers of myocardial ischemia.
Topics: Adenosine Monophosphate; Aged; Biomarkers; Case-Control Studies; Chromatography, High Pressure Liqui | 2005 |
Myocardial glycerol release, arrhythmias and hemodynamic instability during regional ischemia-reperfusion in an open chest pig model.
Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Cardiac Output; Coronary Circulation; Glucose; Glycer | 2006 |
Cardiovascular manifestations of carbon monoxide poisoning.
Topics: Adult; Arrhythmias, Cardiac; Carbon Monoxide Poisoning; Child; Creatine Kinase; Creatine Kinase, MB | 2006 |
Formulation and characterization of poly (D,L-lactide-co-glycolide) nanoparticle containing vascular endothelial growth factor for gene delivery.
Topics: Animals; Chemistry, Pharmaceutical; DNA; Drug Carriers; Lactic Acid; Microscopy, Electron, Transmiss | 2006 |
Age-related differences in myocardial hydrogen ion buffering during ischemia.
Topics: Aging; Animals; Animals, Newborn; Glycolysis; Heart Septum; Heart Ventricles; Histidine; Hydrogenati | 2006 |
[Effect of nanoparticle with vascular endothelial growth factor gene transferred into ischemic myocardium: experiment with rabbits].
Topics: Animals; Enzyme-Linked Immunosorbent Assay; Female; Genetic Therapy; Genetic Vectors; Lactic Acid; M | 2006 |
Influence of fasting on the effects of dimethylamiloride and oxfenicine on ischaemic-reperfused rat hearts.
Topics: Amiloride; Animals; Carnitine O-Palmitoyltransferase; Cell Survival; Enzyme Inhibitors; Fasting; Fat | 2006 |
Evaluation of myocardial metabolism with microdialysis after protection with cold blood- or cold crystalloid cardioplegia. A porcine model.
Topics: Animals; Cardioplegic Solutions; Female; Glycerol; Heart; Heart Arrest, Induced; Hypothermia, Induce | 2006 |
Remote ischaemic preconditioning protects against cardiopulmonary bypass-induced tissue injury: a preclinical study.
Topics: Animals; Cardiac Output; Cardiopulmonary Bypass; Ischemic Preconditioning, Myocardial; Lactic Acid; | 2006 |
Remote ischaemic preconditioning protects against cardiopulmonary bypass-induced tissue injury: a preclinical study.
Topics: Animals; Cardiac Output; Cardiopulmonary Bypass; Ischemic Preconditioning, Myocardial; Lactic Acid; | 2006 |
Remote ischaemic preconditioning protects against cardiopulmonary bypass-induced tissue injury: a preclinical study.
Topics: Animals; Cardiac Output; Cardiopulmonary Bypass; Ischemic Preconditioning, Myocardial; Lactic Acid; | 2006 |
Remote ischaemic preconditioning protects against cardiopulmonary bypass-induced tissue injury: a preclinical study.
Topics: Animals; Cardiac Output; Cardiopulmonary Bypass; Ischemic Preconditioning, Myocardial; Lactic Acid; | 2006 |
Remote ischaemic preconditioning protects against cardiopulmonary bypass-induced tissue injury: a preclinical study.
Topics: Animals; Cardiac Output; Cardiopulmonary Bypass; Ischemic Preconditioning, Myocardial; Lactic Acid; | 2006 |
Remote ischaemic preconditioning protects against cardiopulmonary bypass-induced tissue injury: a preclinical study.
Topics: Animals; Cardiac Output; Cardiopulmonary Bypass; Ischemic Preconditioning, Myocardial; Lactic Acid; | 2006 |
Remote ischaemic preconditioning protects against cardiopulmonary bypass-induced tissue injury: a preclinical study.
Topics: Animals; Cardiac Output; Cardiopulmonary Bypass; Ischemic Preconditioning, Myocardial; Lactic Acid; | 2006 |
Remote ischaemic preconditioning protects against cardiopulmonary bypass-induced tissue injury: a preclinical study.
Topics: Animals; Cardiac Output; Cardiopulmonary Bypass; Ischemic Preconditioning, Myocardial; Lactic Acid; | 2006 |
Remote ischaemic preconditioning protects against cardiopulmonary bypass-induced tissue injury: a preclinical study.
Topics: Animals; Cardiac Output; Cardiopulmonary Bypass; Ischemic Preconditioning, Myocardial; Lactic Acid; | 2006 |
Sustained currents through ASIC3 ion channels at the modest pH changes that occur during myocardial ischemia.
Topics: Acid Sensing Ion Channels; Amiloride; Animals; Cell Line; CHO Cells; Cricetinae; Cricetulus; Electri | 2006 |
High dietary sucrose triggers hyperinsulinemia, increases myocardial beta-oxidation, reduces glycolytic flux and delays post-ischemic contractile recovery.
Topics: Animals; Blood Glucose; Body Weight; Dietary Sucrose; Glycolysis; Hyperinsulinism; In Vitro Techniqu | 2007 |
Levosimendan cardioprotection reduces the metabolic response during temporary regional coronary occlusion in an open chest pig model.
Topics: Animals; Cardiac Output; Cardiotonic Agents; Coronary Circulation; Glucose; Hydrazones; Infusions, I | 2007 |
Effects of balloon occlusion during percutaneous coronary intervention on circulating Ischemia Modified Albumin and transmyocardial lactate extraction.
Topics: Angioplasty, Balloon, Coronary; Balloon Occlusion; Humans; Lactic Acid; Myocardial Ischemia; Serum A | 2006 |
Regionally perfused taurine. Part I. Minimizes lactic acidosis and preserves CKMB and myocardial contractility after ischemia/reperfusion.
Topics: Animals; Cardioplegic Solutions; Cardiotonic Agents; Creatine Kinase, MB Form; DNA; Hypothermia; Lac | 2006 |
Regional myocardial metabolism and electrolyte balance during acute ischemia in dogs.
Topics: Acid-Base Equilibrium; Animals; Dogs; Glucose; Lactic Acid; Myocardial Ischemia; Myocardium; Potassi | 1988 |
Myocardial metabolic monitoring with the microdialysis technique during and after open heart surgery.
Topics: Aged; Analysis of Variance; Biomarkers; Blood Glucose; Coronary Artery Bypass; Glycerol; Humans; Lac | 2007 |
Association of increased myocardial contractility and elevated end-diastolic wall tension with short-term myocardial ischemia: a pressure-volume analysis.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Blood Gas Analysis; Blood Pressure; | 2007 |
An in vitro system to evaluate the effects of ischemia on survival of cells used for cell therapy.
Topics: Animals; Cell Survival; Collagen Type I; Glucose; Hypoxia; In Vitro Techniques; Lactic Acid; Mesench | 2007 |
Inhibition of glycogen synthase kinase-3beta improves tolerance to ischemia in hypertrophied hearts.
Topics: Animals; Body Weight; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Glycolysis; Hyper | 2007 |
ICVTS on-line discussion A. Further testing is warranted to detect more subtle degrees...
Topics: Anaerobic Threshold; Animals; Cardiopulmonary Bypass; Coronary Artery Bypass; Coronary Artery Diseas | 2007 |
Usefulness of BNP-administration in cardiac surgery: animal model.
Topics: Animals; Cardiopulmonary Bypass; Catecholamines; Creatine Kinase; Female; Heart Failure; Hemodynamic | 2007 |
Myocardial substrates in children with congenital heart disease: relationship to substrate supply, age, growth and desaturation.
Topics: 3-Hydroxybutyric Acid; Adolescent; Age Factors; Analysis of Variance; Blood Chemical Analysis; Blood | 2007 |
Ventricle-specific metabolic differences in the newborn piglet myocardium in vivo and during arrested global ischemia.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Adaptation, Physiological; Adenosine Triphosphate; Animals; Animal | 2008 |
Functional recovery of chronic ischemic myocardium after surgical revascularization correlates with magnitude of oxidative metabolism.
Topics: Coronary Artery Bypass; Coronary Circulation; Ethanol; Glucose; Humans; Lactic Acid; Magnetic Resona | 2008 |
Transmural distribution of metabolic abnormalities and glycolytic activity during dobutamine-induced demand ischemia.
Topics: Adenosine Triphosphate; Animals; Coronary Circulation; Coronary Stenosis; Disease Models, Animal; Do | 2008 |
Evidence of pathological coronary flow patterns in patients with isolated coronary artery aneurysms.
Topics: Aged; Angina Pectoris; Blood Flow Velocity; Cohort Studies; Coronary Aneurysm; Coronary Angiography; | 2008 |
Decreases in myocardial glucose and increases in pyruvate but not ischaemia are observed during porcine endotoxaemia.
Topics: Animals; Blood Glucose; Blood Pressure; Disease Models, Animal; Endotoxemia; Glucose; Lactic Acid; M | 2008 |
Is lactate-induced myocardial ischaemic injury mediated by decreased pH or increased intracellular lactate?
Topics: Animals; Energy Metabolism; Extracellular Space; Hydrogen-Ion Concentration; Ion Transport; Lactates | 1995 |
Mechanical and metabolic characterization of ischemic contracture in the neonatal pig heart.
Topics: Animals; Animals, Newborn; Biomechanical Phenomena; Evaluation Studies as Topic; Glucose; Glycolysis | 1995 |
Metabolism of [3-13C]pyruvate and [3-13C]propionate in normal and ischaemic rat heart in vivo: 1H- and 13C-NMR studies.
Topics: Acetyl Coenzyme A; Alanine; Animals; Lactates; Lactic Acid; Magnetic Resonance Spectroscopy; Male; M | 1995 |
Ischemic preconditioning inhibits glycolysis and proton production in isolated working rat hearts.
Topics: Adenosine Triphosphate; Aerobiosis; Animals; Cardiac Pacing, Artificial; Glucose; Glycogen; Glycolys | 1995 |
Cardiac hypertrophy impairs recovery from ischaemia because there is a reduced reactive hyperaemic response.
Topics: Animals; Cardiomegaly; Coronary Circulation; Guinea Pigs; Hyperemia; Lactates; Lactic Acid; Male; My | 1995 |
The influence of lactate, pyruvate and glucose as exogenous substrates on free radical defense mechanisms in isolated rat hearts during ischaemia and reperfusion.
Topics: Animals; Antioxidants; Catalase; Free Radicals; Glucose; Glutathione; Glutathione Peroxidase; Glutat | 1995 |
Acute changes in atrial natriuretic peptide, insulin-like growth factor-1, and lactate levels during left anterior descending coronary artery angioplasty.
Topics: Angioplasty, Balloon, Coronary; Atrial Natriuretic Factor; Constriction, Pathologic; Coronary Diseas | 1995 |
Inhibition of nitric oxide synthesis protects the isolated working rabbit heart from ischaemia-reperfusion injury.
Topics: Animals; Arginine; Glycogen; Heart; Lactates; Lactic Acid; Myocardial Ischemia; Myocardial Reperfusi | 1995 |
Effects of energy demand in ischemic and in hypoxemic isolated rat hearts.
Topics: Anaerobiosis; Animals; Energy Metabolism; Glycolysis; Hypoxia; In Vitro Techniques; Lactates; Lactic | 1994 |
Metabolic adaptation to a gradual reduction in myocardial blood flow.
Topics: Adaptation, Physiological; Adenosine Triphosphate; Animals; Coronary Circulation; Down-Regulation; E | 1995 |
Preconditioning with dobutamine in the isolated rat heart.
Topics: Animals; Dobutamine; Drug Interactions; Heart; Heart Rate; Lactates; Lactic Acid; Male; Myocardial C | 1995 |
Detection of intraoperative myocardial ischaemia--a comparison among electrocardiographic, myocardial metabolic, and haemodynamic measurements in patients with reduced ventricular function.
Topics: Aged; Electrocardiography; Female; Hemodynamics; Humans; Intraoperative Complications; Lactates; Lac | 1995 |
A study on dilazep: I. Mechanism of anti-ischemic action of dilazep is not coronary vasodilation but decreased cardiac mechanical function in the isolated, working rat heart.
Topics: Animals; Arachidonic Acid; Coronary Circulation; Coronary Vessels; Dilazep; Fatty Acids, Nonesterifi | 1995 |
Effects of moderate repetitive ischemia on myocardial substrate utilization.
Topics: Adenine Nucleotides; Animals; Fatty Acids; Glucose; Glycogen; Glycolysis; Lactates; Lactic Acid; Myo | 1995 |
Bidirectional effects of aminophylline on myocardial ischemia.
Topics: Adenosine; Aminophylline; Animals; Coronary Circulation; Dogs; Heart; Lactates; Lactic Acid; Myocard | 1995 |
Does interstitial adenosine mediate acute hibernation of guinea pig myocardium?
Topics: 5'-Nucleotidase; Acute Disease; Adenosine; Adenosine Diphosphate; Adenosine Triphosphate; Animals; C | 1995 |
Dynamics of myocardial metabolism in the preconditioned porcine heart studied using continuous microdialysis.
Topics: Adenine Nucleotides; Animals; Cardiac Output; Chromatography, High Pressure Liquid; Disease Models, | 1995 |
Captopril cardioplegia on myocardial protection in the hypertrophied rat hearts.
Topics: Animals; Captopril; Coronary Circulation; Creatine Kinase; Heart Arrest, Induced; Hypertrophy, Left | 1994 |
Does hemoglobin concentration affect perioperative myocardial lactate flux in patients undergoing coronary artery bypass surgery?
Topics: Adult; Aged; Aged, 80 and over; Anesthesia; Blood Pressure; Cardiac Output; Coronary Artery Bypass; | 1995 |
Effects of sepsis on recovery of the heart from 50 min ischemia.
Topics: Adenosine Triphosphate; Alcoholism; Animals; Catalase; Escherichia coli; Lactates; Lactic Acid; Male | 1994 |
Exercise-induced rise in arterial potassium is enhanced in patients with impaired exercise tolerance.
Topics: Aged; Anaerobic Threshold; Arteries; Electrocardiography; Exercise Test; Exercise Tolerance; Humans; | 1995 |
Technetium-99m-nitroimidazole (BMS181321): a positive imaging agent for detecting myocardial ischemia.
Topics: Animals; Coronary Circulation; Dogs; Heart; Lactates; Lactic Acid; Myocardial Ischemia; Nitroimidazo | 1995 |
Nitric oxide accounts for postischemic cardioprotection resulting from angiotensin-converting enzyme inhibition: indirect evidence for a radical scavenger effect in isolated guinea pig heart.
Topics: Acridines; Angiotensin-Converting Enzyme Inhibitors; Animals; Cricetinae; Cyclic GMP; Free Radical S | 1995 |
Preconditioning with a single short episode of global ischemia in the isolated working rat heart: effect on structure, mechanical function, and energy metabolism for various durations of sustained global ischemia.
Topics: Animals; Chromatography, High Pressure Liquid; Energy Metabolism; Glycogen; Heart; Heart Arrest; In | 1995 |
Continuous monitoring of energy metabolites using microdialysis during myocardial ischaemia in the pig.
Topics: Adenosine; Animals; Energy Metabolism; Female; Guanosine; Hemodynamics; Hypoxanthine; Hypoxanthines; | 1995 |
Protective effects of halothane but not isoflurane against global ischaemic injury in the isolated working rat heart.
Topics: Animals; Halothane; Heart; In Vitro Techniques; Isoflurane; Lactates; Lactic Acid; Myocardial Contra | 1995 |
Preischaemic as well as postischaemic application of a calcium antagonist affords cardioprotection in the isolated guinea pig heart.
Topics: Animals; Coronary Circulation; Gallopamil; Glutathione; Guinea Pigs; Heart; Lactates; Lactic Acid; L | 1995 |
Mechanisms of intracellular pH regulation during postischemic reperfusion of diabetic rat hearts.
Topics: Amiloride; Animals; Bicarbonates; Diabetes Mellitus, Experimental; HEPES; Hydrogen-Ion Concentration | 1995 |
Effects of diazoxide on norepinephrine-induced vasocontraction and ischemic myocardium in rats.
Topics: Analysis of Variance; Animals; Aorta, Thoracic; Calcium; Diazoxide; Disease Models, Animal; Dose-Res | 1994 |
1H NMR detection of lactate and alanine in perfused rat hearts during global and low pressure ischemia.
Topics: Alanine; Animals; Glycogen; Heart; Isoproterenol; Lactates; Lactic Acid; Magnetic Resonance Spectros | 1995 |
Gradual onset of myocardial ischemia results in reduced myocardial infarction. Association with reduced contractile function and metabolic downregulation.
Topics: Animals; Coronary Circulation; Down-Regulation; Hemodynamics; Hydrogen-Ion Concentration; Lactates; | 1995 |
Correlation between myocardial blood flow and tissue succinate during acute ischemia.
Topics: Acute Disease; Animals; Biomarkers; Coronary Circulation; Dogs; Female; Lactates; Lactic Acid; Male; | 1994 |
Vessel tone affects transmural distribution of coronary flow during hypoperfusion.
Topics: Adenosine; Animals; Blood Pressure; Coronary Circulation; Endothelins; Female; Hemodynamics; Lactate | 1995 |
Lipoamide influences substrate selection in post-ischaemic perfused rat hearts.
Topics: Acetates; Acetylation; Animals; Aspartic Acid; Binding, Competitive; Carbon Isotopes; Glutamates; Gl | 1994 |
Comparison of effects of aprikalim and of hypoxic and ischaemic preconditioning on extracellular potassium accumulation, metabolism, and functional recovery of the globally ischaemic rat heart.
Topics: Animals; Antihypertensive Agents; Basal Metabolism; Extracellular Space; Heart; Hypoxia; Lactates; L | 1994 |
Role of aspirin in modulating myocardial ischemic reperfusion injury.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Aspirin; Blood Pressure; Creatinine; Disease | 1994 |
Preconditioning human ventricular cardiomyocytes with brief periods of simulated ischaemia.
Topics: Cells, Cultured; Humans; Hydrogen-Ion Concentration; L-Lactate Dehydrogenase; Lactates; Lactic Acid; | 1994 |
Chronic gliclazide treatment affects basal and post-ischemic cardiac function in diabetic rats.
Topics: Adenosine Triphosphate; Animals; Diabetes Mellitus, Experimental; Gliclazide; Heart; Lactates; Lacti | 1994 |
Evaluation of post-ischemic myocardial metabolism by 1H-magnetic resonance spectroscopy in the rabbit heart.
Topics: Alanine; Animals; Carnitine; Hydrogen; Lactates; Lactic Acid; Magnetic Resonance Spectroscopy; Myoca | 1994 |
Ischemic dysfunction and impaired recovery in hypertensive hypertrophied hearts is associated with exaggerated intracellular sodium accumulation.
Topics: Adenosine Triphosphate; Animals; Cardiomegaly; Hydrogen-Ion Concentration; Hypertension; Lactates; L | 1994 |
Ischaemic episodes of less than 5 minutes produce preconditioning but not stunning in the isolated rat heart.
Topics: Adenosine; Animals; Arrhythmias, Cardiac; Conditioning, Psychological; Coronary Circulation; Energy | 1994 |
Comparison of the effects of dobutamine and isoproterenol in ischemic hearts by phosphorus-31 nuclear magnetic resonance spectroscopy.
Topics: Animals; Coronary Circulation; Dobutamine; Dogs; Female; Hemodynamics; Isoproterenol; Lactates; Lact | 1994 |
Adenosine: a sensitive marker of myocardial ischaemia in man.
Topics: Adenosine; Aged; Angioplasty, Balloon, Coronary; Biomarkers; Coronary Circulation; Coronary Disease; | 1994 |
Metabolic recovery of isolated working rat heart after brief global ischemia.
Topics: 3-Hydroxybutyric Acid; Adenosine Triphosphate; Animals; Fasting; Glucose-6-Phosphate; Glucosephospha | 1994 |
[The cardioprotective effect of alpha-tocopherol and pantenol in a model of experimental ischemia-reperfusion of the isolated heart].
Topics: Adenosine Triphosphate; Animals; In Vitro Techniques; Lactates; Lactic Acid; Lipid Peroxidation; Mal | 1994 |
Simultaneous measurement of both lipid and lactate in isolated rat hearts by 1H NMR spectroscopy.
Topics: Animals; Dietary Fats; Glycolysis; In Vitro Techniques; Iodoacetates; Iodoacetic Acid; Lactates; Lac | 1993 |
The relative importance of myocardial energy metabolism compared with ischemic contracture in the determination of ischemic injury in isolated perfused rabbit hearts.
Topics: Animals; Creatine Kinase; Diacetyl; Energy Metabolism; Glucose; Glycogen; Lactates; Lactic Acid; Myo | 1994 |
Lactate transport in mammalian ventricle. General properties and relation to K+ fluxes.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Carrier Proteins; Female; Guinea Pigs; La | 1994 |
Endocardial and epicardial interstitial purines and lactate during graded ischemia.
Topics: Adenosine; Animals; Coronary Circulation; Dogs; Endocardium; Extracellular Space; Female; Lactates; | 1994 |
Effect of ischemic preconditioning on interstitial purine metabolite and lactate accumulation during myocardial ischemia.
Topics: Adenosine; Animals; Dogs; Extracellular Space; Female; Hypoxanthine; Hypoxanthines; Inosine; Lactate | 1994 |
The effects of exogenous lactate and pyruvate on the recovery of coronary flow in the rat heart after ischaemia.
Topics: Animals; Coronary Circulation; Glucose; In Vitro Techniques; L-Lactate Dehydrogenase; Lactates; Lact | 1993 |
Muscarinic receptor stimulation by carbachol improves functional recovery in isolated, blood perfused rabbit heart.
Topics: Adenosine Triphosphate; Animals; Atropine; Blood Pressure; Carbachol; Cardiac Pacing, Artificial; Co | 1993 |
Attenuation of postischaemic dysfunction by ischaemic preconditioning is not mediated by adenosine in the isolated rat heart.
Topics: Adenosine; Animals; Blood Pressure; Heart Rate; Lactates; Lactic Acid; Male; Myocardial Infarction; | 1993 |
Close correlations between mitochondrial swelling and ATP-content in the ischemic canine myocardium. A combined morphometric and biochemical study.
Topics: Adenosine Triphosphate; Animals; Dogs; Hydrogen-Ion Concentration; Lactates; Lactic Acid; Microscopy | 1993 |
Comparative effects of ischemia and hypoxemia on left ventricular systolic and diastolic function in humans.
Topics: Adult; Aged; Coronary Circulation; Diastole; Female; Humans; Hydrogen; Hypoxia; Lactates; Lactic Aci | 1993 |
Effects of brief repetitive ischemia on contractility, relaxation, and coronary flow. Exaggerated postischemic diastolic dysfunction in pressure-overload hypertrophy.
Topics: Animals; Cardiomegaly; Coronary Circulation; Diastole; Glycolysis; Lactates; Lactic Acid; Male; Myoc | 1993 |
Protective effects of ranolazine in guinea-pig hearts during low-flow ischaemia and their association with increases in active pyruvate dehydrogenase.
Topics: Acetanilides; Adenosine Triphosphate; Angina Pectoris; Animals; Creatine Kinase; Female; Glycogen; G | 1993 |
Na+/H+ exchange inhibitors reverse lactate-induced depression in postischaemic ventricular recovery.
Topics: Amiloride; Animals; Carrier Proteins; Heart; Hydrogen; In Vitro Techniques; Lactates; Lactic Acid; M | 1993 |
Mechanisms of pHi recovery after global ischemia in the perfused heart.
Topics: Animals; Bicarbonates; Carbon Dioxide; Carrier Proteins; Ferrets; Hydrogen-Ion Concentration; In Vit | 1993 |
Substrate-induced changes in the lipid content of ischemic and reperfused myocardium. Its relation to hemodynamic recovery.
Topics: Animals; Disease Models, Animal; Fatty Acids; Glucose; Glycerol; Heart; Lactates; Lactic Acid; Male; | 1993 |
Mechanisms of ATP conservation during ischemia in slow and fast heart rate hearts.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Calcium; Dogs; Female; Heart Rate; Hydro | 1993 |
Beneficial effect of carnitine on mechanical recovery of rat hearts reperfused after a transient period of global ischemia is accompanied by a stimulation of glucose oxidation.
Topics: Acyl Coenzyme A; Adenosine Triphosphate; Animals; Carnitine; Esters; Glucose; Glycolysis; Heart; In | 1993 |
Superoxide dismutase restores contractile and metabolic dysfunction through augmentation of adenosine release in coronary microembolization.
Topics: 5'-Nucleotidase; Adenosine; Animals; Coronary Circulation; Dogs; Embolism; Injections; Lactates; Lac | 1993 |
Adenosine increases lactate release and delays onset of contracture during global low flow ischaemia.
Topics: Adenine; Adenosine; Animals; Glucose; Lactates; Lactic Acid; Male; Myocardial Contraction; Myocardia | 1993 |
Effect of prostaglandins I2 (prostacyclin) and F2 alpha on function, energy metabolism, and calcium uptake in ischaemic/reperfused hearts.
Topics: Adenosine Triphosphate; Animals; Blood Pressure; Calcium; Dinoprost; Energy Metabolism; Epoprostenol | 1993 |
Intramyocardial hypercarbic acidosis during cardiac arrest and resuscitation.
Topics: Acidosis, Respiratory; Animals; Carbon Dioxide; Disease Models, Animal; Heart Arrest; Hemodynamics; | 1993 |
Short-term effects of atrial versus atrio-ventricular pacing on myocardial ischaemia in coronary artery disease patients.
Topics: Adult; Angina Pectoris; Blood Pressure; Bundle of His; Bundle-Branch Block; Cardiac Catheterization; | 1993 |
Release of atrial natriuretic peptide in relation to metabolic changes during myocardial ischaemia induced by coronary angioplasty.
Topics: Adult; Aged; Angioplasty, Balloon, Coronary; Atrial Natriuretic Factor; Coronary Circulation; Corona | 1993 |
The role of Na+/K+ ATPase activity during low flow ischemia in preventing myocardial injury: a 31P, 23Na and 87Rb NMR spectroscopic study.
Topics: Animals; Energy Metabolism; Glucose; Glycogen; Glycolysis; Hydrogen-Ion Concentration; In Vitro Tech | 1995 |
Increased release of NO during ischemia reduces myocardial contractility and improves metabolic dysfunction.
Topics: Animals; Arginine; Calcium Chloride; Dogs; Hydrogen-Ion Concentration; Isoproterenol; Lactates; Lact | 1996 |
Is a high glycogen content beneficial or detrimental to the ischemic rat heart? A controversy resolved.
Topics: Adenosine Triphosphate; Animals; Coronary Circulation; Glycogen; Glycolysis; Hydrolysis; In Vitro Te | 1996 |
Improvement of myocardial ischemic dysfunction with dichloroacetic acid: experimental study by repeated ischemia in dogs.
Topics: Animals; Blood Glucose; Calcium; Coronary Circulation; Dichloroacetic Acid; Dogs; Fatty Acids, Nones | 1995 |
Dichotomy of ischemic preconditioning: improved postischemic contractile function despite intensification of ischemic contracture.
Topics: Animals; Cardioplegic Solutions; Heart Arrest, Induced; Lactates; Lactic Acid; Male; Myocardial Cont | 1996 |
[Comparison between intermittent retrograde cold blood cardioplegia and retrograde crystalloid cardioplegia].
Topics: Aged; Bicarbonates; Calcium Chloride; Cardiopulmonary Bypass; Creatine Kinase; Female; Heart Arrest, | 1996 |
Release of ischemia in paced rat Langendorff hearts by supply of L-carnitine: role of endogenous long-chain acylcarnitine.
Topics: Aerobiosis; Animals; Cardiac Pacing, Artificial; Carnitine; Cations; Cell Membrane; Cells, Cultured; | 1996 |
Effect of ischemic preconditioning on mitochondrial oxidative phosphorylation and high energy phosphates in rat hearts.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Anaerobiosis; Animals; Creatine; Creatine Kinase; | 1996 |
A protective role of nitric oxide in isolated ischaemic/reperfused rat heart.
Topics: Adenosine; Animals; Arginine; Coronary Circulation; Heart; Lactates; Lactic Acid; Male; Myocardial I | 1995 |
[Detection of stress-induced myocardial ischemia in isolated coronary ectasia and aneurysm (dilatative coronaropathy)].
Topics: Adult; Aged; Coronary Aneurysm; Coronary Angiography; Diagnosis, Differential; Electrocardiography; | 1996 |
Reducing lactate accumulation does not attenuate lethal ischemic injury in isolated perfused rat hearts.
Topics: Animals; Creatine Kinase; Energy Metabolism; Glucagon; Glycogen; In Vitro Techniques; Lactic Acid; M | 1996 |
Hydroxyl radical production during myocardial ischemia and reperfusion in cats.
Topics: Animals; Cats; Deferoxamine; Female; Free Radical Scavengers; Heart Ventricles; Hydroxyl Radical; La | 1996 |
Cellular response to reperfused oxygen in the postischemic myocardium.
Topics: Animals; Cardiotonic Agents; Energy Metabolism; Hydrogen-Ion Concentration; In Vitro Techniques; Int | 1996 |
Recovery of glycolysis and oxidative metabolism during postischemic reperfusion of hypertrophied rat hearts.
Topics: Adenosine Triphosphate; Animals; Aorta; Cardiomegaly; Constriction; Glucose; Glycolysis; Heart; Home | 1996 |
Cardioplegic protection of hearts with pre-arrest ischaemic injury: effect of glucose, aspartate, and lactobionate.
Topics: Animals; Aspartic Acid; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Chlorides; Disacchar | 1995 |
Acute necrotizing pancreatitis, lactic acidosis and prolonged hypoglycemia in a hemodialysed patient--a logical but unfortunately fatal combination.
Topics: Acidosis, Lactic; Blood Gas Analysis; Blood Glucose; Diabetes Mellitus, Type 2; Fatal Outcome; Femal | 1996 |
Coronary vascular effects of dexmedetomidine during reactive hyperemia in the anesthetized dog.
Topics: Adrenergic alpha-Agonists; Anesthesia; Animals; Coronary Circulation; Dogs; Female; Hyperemia; Imida | 1996 |
Calcium improves mechanical function and carbohydrate metabolism following ischemia in isolated Bi-ventricular working hearts from immature rabbits.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Calcium; Dichloroacetic Acid; Dose-Response Relat | 1996 |
Beneficial effects of felodipine on myocardial and coronary function during low-flow ischemia and reperfusion.
Topics: Adenosine Triphosphate; Animals; Calcium Channel Blockers; Coronary Circulation; Dose-Response Relat | 1996 |
Endogenous adenosine increases O2 utilisation efficiency in isoprenaline-stimulated canine myocardium.
Topics: Adenine; Adenosine; Adenosine Deaminase; Adrenergic beta-Agonists; Animals; Dogs; Hypoxia; Isoproter | 1996 |
Glyburide enhancement of lactate production in ischemic heart is modified by preconditioning: an in vivo experimental study in pigs by microdialysis technique.
Topics: Adenosine Triphosphate; Animals; Female; Glyburide; Hypoglycemic Agents; Ischemic Preconditioning, M | 1996 |
Biochemical and morphological changes in isolated rabbit hearts after prolonged hypothermic ischaemia: comparison of two cardioplegic solutions.
Topics: Adenosine; Allopurinol; Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Creatine Ki | 1995 |
Failure to demonstrate myocardial ischaemia in patients with angina and normal coronary arteries. Evaluation by continuous coronary sinus pH monitoring and lactate metabolism.
Topics: Adult; Blood Flow Velocity; Cardiac Catheterization; Cardiac Pacing, Artificial; Coronary Angiograph | 1996 |
Metabolic effects of ischemic preconditioning and adenosine receptor blockade in dogs.
Topics: Adenosine; Animals; Creatine; Dogs; Female; Lactic Acid; Male; Myocardial Ischemia; Purinergic P1 Re | 1996 |
Metabolic adaptation during a sequence of no-flow and low-flow ischemia. A possible trigger for hibernation.
Topics: Adaptation, Physiological; Animals; Biomechanical Phenomena; Calcium; Coronary Circulation; Creatine | 1996 |
Fasting, lactate, and insulin improve ischemia tolerance in rat heart: a comparison with ischemic preconditioning.
Topics: Animals; Fasting; Glucose; Glycogen; Heart; Insulin; Ischemic Preconditioning, Myocardial; Lactic Ac | 1996 |
Effects of beta-blockade and atropine on ischemic responses in left ventricular regions subtending coronary stenosis during dobutamine stress echocardiography.
Topics: Adrenergic beta-Antagonists; Animals; Atropine; Cardiotonic Agents; Coronary Circulation; Coronary D | 1996 |
Effects of thoracic epidural anesthesia on changes in ischemic myocardial metabolism induced by intracoronary injection of endothelin in dogs.
Topics: Adenosine Triphosphate; Anesthesia, Epidural; Animals; Coronary Circulation; Dogs; Endothelins; Fema | 1996 |
Dynamics of myocardial adaptation to low-flow ischemia and hypoxemia.
Topics: Adaptation, Physiological; Animals; Coronary Circulation; Heart; Hypoxia; In Vitro Techniques; Lacti | 1996 |
Protection of ischemic myocardium by inhibition of contracture in isolated rat heart.
Topics: Adenosine Triphosphate; Animals; Calcium; Contracture; Diacetyl; Energy Metabolism; Heart; In Vitro | 1996 |
Myocardial glycogen depletion cannot explain the cardioprotective effects of ischemic preconditioning in the rat heart.
Topics: Adenosine Triphosphate; Animals; Glucose-6-Phosphate; Glycogen; In Vitro Techniques; Ischemic Precon | 1996 |
Maldistribution of multidose blood cardioplegia: pharmacologic intervention to prevent subendocardial hypoperfusion by alpha-adrenergic blockade.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Flow Velocity; Cardioplegic Solutions; Coronary Vessels | 1997 |
Low-dose inotropic stimulation during left ventricular ischaemia does not worsen post-ischaemic dysfunction.
Topics: Animals; Cardiotonic Agents; Disease Models, Animal; Dobutamine; Female; Heart Rate; Lactic Acid; My | 1996 |
Intracoronary application of C1 esterase inhibitor improves cardiac function and reduces myocardial necrosis in an experimental model of ischemia and reperfusion.
Topics: Anaphylatoxins; Animals; Complement C1 Inactivator Proteins; Coronary Vessels; Creatine Kinase; Fema | 1997 |
Decreased myocardial glucose uptake during ischemia in diabetic swine.
Topics: Animals; Blood Glucose; Coronary Circulation; Diabetes Mellitus, Experimental; Fasting; Fatty Acids, | 1997 |
Effect of mivazerol on myocardial lactate production, blood flow and electrocardiographic signs of ischaemia induced by coronary artery ligation in the anaesthetised dog.
Topics: Adrenergic alpha-Agonists; Anesthesia, General; Animals; Blood Pressure; Coronary Circulation; Coron | 1997 |
Acute myocardial ischaemia induces cardiac carnitine release in man.
Topics: Adult; Aged; Cardiac Pacing, Artificial; Carnitine; Coronary Disease; Female; Hemodynamics; Humans; | 1997 |
Acute and chronic cocaine exposure can produce myocardial ischemia and infarction in Yucatan swine.
Topics: Animals; Cholesterol; Cocaine; Coronary Angiography; Coronary Vessels; Female; Hemodynamics; Lactic | 1997 |
Adenosine receptor blockade enhance glycolysis in hypoperfused guinea-pig myocardium.
Topics: Adenosine; Animals; Enzyme Activation; Glucose; Glycogen; Glycolysis; Guinea Pigs; In Vitro Techniqu | 1997 |
Preischemic bradykinin and ischaemic preconditioning in functional recovery of the globally ischaemic rat heart.
Topics: Adenosine Triphosphate; Animals; Bradykinin; Bradykinin Receptor Antagonists; Glucose; Glycogen; Isc | 1997 |
Effect of ischaemia and reperfusion on the intracellular concentration of taurine and glutamine in the hearts of patients undergoing coronary artery surgery.
Topics: Adenosine Triphosphate; Aged; Bicarbonates; Biomarkers; Blood; Calcium Chloride; Cardioplegic Soluti | 1997 |
Correlation of adenosine thallium 201 perfusion patterns with markers for inducible ischemia.
Topics: Adenosine; Coronary Angiography; Coronary Circulation; Coronary Disease; Echocardiography; Electroca | 1997 |
Adaptation to myocardial ischemia during coronary angioplasty demonstrated by clinical, electrocardiographic, echocardiographic, and metabolic parameters.
Topics: Angioplasty, Balloon, Coronary; Coronary Disease; Echocardiography; Electrocardiography; Humans; Isc | 1997 |
Regulation of beta 2-adrenergic receptors on mononuclear leukocytes in patients with acute ischemic heart disease.
Topics: Acute Disease; Aged; Angina Pectoris; Blood Glucose; Cardiopulmonary Resuscitation; Catecholamines; | 1997 |
Myocardial protection with special reference to ischemic preconditioning. An experimental study in the pig using a microdialysis technique.
Topics: Adenosine; Adenosine Triphosphate; Animals; Glyburide; In Vitro Techniques; Ischemic Preconditioning | 1997 |
Augmented release of brain natriuretic peptide during reperfusion of the human heart after cardioplegic cardiac arrest.
Topics: Adult; Aged; Atrial Natriuretic Factor; Biomarkers; Coronary Artery Bypass; Extracorporeal Circulati | 1997 |
Intermittent ischemia: energy metabolism, cellular volume regulation, adenosine and insights into preconditioning.
Topics: Adenosine; Animals; Cell Size; Creatine; Energy Metabolism; Glyburide; Glycogen; Glycolysis; In Vitr | 1997 |
Open-system kinetics of myocardial phosphoenergetics during coronary underperfusion.
Topics: Animals; Energy Metabolism; Female; Freezing; In Vitro Techniques; Kinetics; Lactic Acid; Magnetic R | 1997 |
A conducting salt-based amperometric biosensor for measurement of extracellular lactate accumulation in ischemic myocardium.
Topics: Animals; Biosensing Techniques; Heart Ventricles; Humans; Hydrogen-Ion Concentration; Lactic Acid; M | 1997 |
Coronary sinus lactates, coronary artery disease and normal coronary arteries.
Topics: Angina Pectoris; Coronary Vessels; Humans; Hydrogen-Ion Concentration; Lactic Acid; Microvascular An | 1997 |
Myocardial adaptation to acute oxygen shortage. A kinetic analysis.
Topics: Adaptation, Physiological; Adenosine Triphosphate; Animals; Energy Metabolism; Glycogen; Hypoxia; In | 1997 |
Myocardial protection of contractile function after global ischemia by physiologic estrogen replacement in the ovariectomized rat.
Topics: Animals; Body Weight; Coronary Circulation; Creatine Kinase; Estradiol; Female; Heart; In Vitro Tech | 1997 |
Glycogen utilization and ischemic injury in the isolated rat heart.
Topics: Animals; Creatine Kinase; Fasting; Glycogen; Glycolysis; Hydrogen-Ion Concentration; Lactic Acid; Ma | 1997 |
Cardiac release and kinetics of endothelin after severe short-lasting myocardial ischemia.
Topics: Cardiac Pacing, Artificial; Case-Control Studies; Creatine Kinase; Electrocardiography; Endothelins; | 1997 |
Determinative role of peroxidized low-density lipoprotein in myocardial thromboxane synthesis during pacing-induced ischaemia in humans.
Topics: Analysis of Variance; Cardiac Pacing, Artificial; Electrocardiography; Female; Humans; Lactic Acid; | 1998 |
Relation between QT dispersion and the extent of myocardial ischemia in patients with three-vessel coronary artery disease.
Topics: Aged; Electrocardiography; Female; Heart Conduction System; Humans; Lactic Acid; Male; Middle Aged; | 1998 |
Lactate-induced vascular relaxation in porcine coronary arteries is mediated by Ca2+-activated K+ channels.
Topics: Animals; Calcium; Coronary Vessels; Hydrogen-Ion Concentration; Hypoxia; In Vitro Techniques; Lactic | 1998 |
Inhibition of nitric oxide synthesis aggravates myocardial ischemia in hemorrhagic shock in constant pressure model.
Topics: Adenosine Triphosphate; Animals; Aorta; Catecholamines; Disease Models, Animal; Dogs; Enzyme Inhibit | 1998 |
Characterization of metabolic responses to low-flow ischemia in intact pig hearts and isolated blood-perfused neonatal pig hearts.
Topics: Adaptation, Physiological; Anaerobic Threshold; Animals; Animals, Newborn; Blood Flow Velocity; Carb | 1998 |
Regulation of pyruvate dehydrogenase activity and glucose metabolism in post-ischaemic myocardium.
Topics: Animals; Dichloroacetic Acid; Dogs; Glucose; Lactic Acid; Myocardial Ischemia; Myocardial Reperfusio | 1998 |
Angina pectoris caused by coronary microvascular spasm.
Topics: Acetylcholine; Aged; Angina, Unstable; Coronary Angiography; Coronary Artery Disease; Coronary Circu | 1998 |
Hypothermia increases the threshold for ischemic preconditioning.
Topics: Animals; Body Temperature; Coronary Circulation; Disease Models, Animal; Glycogen; Hypothermia, Indu | 1998 |
Administration of fructose 1,6-diphosphate during early reperfusion significantly improves recovery of contractile function in the postischemic heart.
Topics: Adenosine Triphosphate; Animals; Calcium; Fructosediphosphates; Glucose; Immunologic Factors; Lactic | 1998 |
Technetium-99m-nitroimadazole uptake in a swine model of demand ischemia.
Topics: Animals; Cardiac Pacing, Artificial; Heart; Hemodynamics; Lactic Acid; Myocardial Ischemia; Myocardi | 1998 |
Trimetazidine-induced enhancement of myocardial glucose utilization in normal and ischemic myocardial tissue: an evaluation by positron emission tomography.
Topics: Animals; Blood Flow Velocity; Coronary Circulation; Dogs; Dose-Response Relationship, Drug; Fatty Ac | 1998 |
Myocardial metabolism studied during warm blood antero-retrograde reperfusion in ischaemic human hearts.
Topics: Adult; Aged; Alanine; Blood; Energy Metabolism; Fatty Acids, Nonesterified; Female; Hot Temperature; | 1998 |
Glucose delivery is a major determinant of glucose utilisation in the ischemic myocardium with a residual coronary flow.
Topics: Animals; Blood Flow Velocity; Coronary Circulation; Dose-Response Relationship, Drug; Fructosephosph | 1998 |
Ischemic threshold during cold blood cardioplegic arrest: monitoring with tissue pH and pO2.
Topics: Anaerobic Threshold; Animals; Biomarkers; Creatine Kinase; Dogs; Heart Arrest, Induced; Hydrogen-Ion | 1998 |
Electrodeposited iridium oxide pH electrode for measurement of extracellular myocardial acidosis during acute ischemia.
Topics: Acidosis; Acute Disease; Animals; Electrodes; Extracellular Space; Hydrogen-Ion Concentration; Iridi | 1998 |
Intraoperative release of troponin T in coronary venous and arterial blood and its relation to recovery of left ventricular function and oxidative metabolism following coronary artery surgery.
Topics: Biomarkers; Coronary Artery Bypass; Coronary Circulation; Coronary Disease; Creatine Kinase; Female; | 1998 |
Metabolic differences between hearts of patients with aortic valve disease and hearts of patients with ischaemic disease.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Amino Acids; Aortic Valve Insufficiency; Energy Metab | 1998 |
Surgical procedure affects physiological parameters in rat myocardial ischemia: need for mechanical ventilation.
Topics: Animals; Arteries; Blood Pressure; Disease Models, Animal; Electrocardiography; Electrolytes; Female | 1999 |
Reversal of permeability transition during recovery of hearts from ischemia and its enhancement by pyruvate.
Topics: Adenine Nucleotides; Animals; Capillary Permeability; Deoxyglucose; Hydrogen-Ion Concentration; In V | 1999 |
Myocardial outflow of calcitonin gene-related peptide in relation to metabolic stress during coronary artery bypass grafting without cardiopulmonary bypass.
Topics: Aged; Calcitonin Gene-Related Peptide; Cardiopulmonary Bypass; Coronary Artery Bypass; Coronary Circ | 1999 |
Myocardial metabolism of 123I-BMIPP in a canine model with ischemia: implications of perfusion-metabolism mismatch on SPECT images in patients with ischemic heart disease.
Topics: Animals; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Coronary Circulation; Dog | 1999 |
Temporal differences in actions of calcium channel blockers on K+ accumulation, cardiac function, and high-energy phosphate levels in ischemic guinea pig hearts.
Topics: Acidosis; Adenosine Triphosphate; Animals; Calcium Channel Blockers; Depression, Chemical; Diltiazem | 1999 |
S(+)-ketamine, but not R(-)-ketamine, reduces postischemic adherence of neutrophils in the coronary system of isolated guinea pig hearts.
Topics: Anesthetics, Dissociative; Animals; Cell Adhesion; Coronary Vessels; Guinea Pigs; Humans; Ketamine; | 1999 |
Atenolol depresses post-ischaemic recovery in the isolated rat heart.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Adrenergic beta-Antagonists; Analysis of Variance; Anim | 1999 |
Levosimendan: effects of a calcium sensitizer on function and arrhythmias and cyclic nucleotide levels during ischemia/reperfusion in the Langendorff-perfused guinea pig heart.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium Channel Agoni | 1999 |
Perflubron emulsion improves tolerance to low-flow ischemia in isolated rabbit hearts.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Coronary Vessels; F | 1999 |
Role of protons in activation of cardiac sympathetic C-fibre afferents during ischaemia in cats.
Topics: Acid-Base Equilibrium; Adrenergic Fibers; Animals; Buffers; Cats; Chest Pain; Coronary Vessels; Elec | 1999 |
Cytosolic redox state mediates postischemic response to pyruvate dehydrogenase stimulation.
Topics: Animals; Cytosol; Heart; In Vitro Techniques; Lactic Acid; Magnetic Resonance Spectroscopy; Myocardi | 1999 |
A model of low-flow ischemia and reperfusion in single, beating adult cardiomyocytes.
Topics: Animals; Calcium; Cell Survival; Coronary Circulation; Electric Stimulation; Hydrogen-Ion Concentrat | 1999 |
Metabolic and functional effects of low-potassium cardioplegic solutions for long-term heart preservation.
Topics: Animals; Blood Pressure; Cardioplegic Solutions; Creatine Kinase; Energy Metabolism; Heart Arrest, I | 1999 |
Changes in endothelium-derived vascular regulatory factors during dobutamine-stress-induced silent myocardial ischemia in patients with Kawasaki disease.
Topics: Adolescent; Calcinosis; Cardiomyopathies; Child; Child, Preschool; Coronary Angiography; Dobutamine; | 1999 |
Transmyocardial laser revascularisation has no beneficial effect on high energy phosphates and lactate content during acute myocardial ischaemia in pigs.
Topics: Acute Disease; Animals; Biopsy; Chromatography, High Pressure Liquid; Coloring Agents; Disease Model | 1999 |
Effects of lactate on intracellular pH and hypercontracture during simulated ischemia and reperfusion in cardiac ventricular myocytes of the guinea pig.
Topics: Animals; Cytosol; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; Heart Ventric | 1999 |
Low-dose calcium antagonists reduce energy demand and cellular damage of isolated hearts during both ischemia and reperfusion.
Topics: Amlodipine; Animals; Calcium Channel Blockers; Coronary Circulation; Diltiazem; Dose-Response Relati | 1999 |
Exercise-induced myocardial ischemia in isolated coronary artery ectasias and aneurysms ("dilated coronopathy").
Topics: Coronary Aneurysm; Coronary Angiography; Coronary Vessels; Dilatation, Pathologic; Exercise Test; Fe | 1999 |
Sevoflurane and isoflurane do not enhance the pre- and postischemic eicosanoid production in guinea pig hearts.
Topics: Anesthetics, Inhalation; Animals; Coronary Circulation; Dinoprost; Eicosanoids; Guinea Pigs; Hemodyn | 2000 |
Comparison of local and systemic effects of insulin on myocardial glucose extraction in ischemic heart disease.
Topics: Aged; Blood Glucose; Coronary Vessels; Fatty Acids, Nonesterified; Glucose; Heart; Hemodynamics; Hum | 2000 |
A new method of long-term preventive cardioprotection using Lactobacillus.
Topics: Adenosine Triphosphate; Animals; Body Temperature; Cardiovascular Agents; Catalase; Coronary Circula | 2000 |
Effect of Celsior and University of Wisconsin solutions on myocardial metabolism and function after warm ischemia.
Topics: Acid-Base Equilibrium; Adenosine; Allopurinol; Animals; Creatine Kinase; Dogs; Energy Metabolism; Gl | 1999 |
Fructose-2,6-bisphosphate, a potent stimulator of phosphofructokinase, is increased by high exogenous glucose perfusion.
Topics: Adenosine Triphosphate; Animals; Glucose; Glycogen; Glycolysis; Hemodynamics; Lactic Acid; Myocardia | 2000 |
Improved myocardial preservation with short hyperthermia prior to cold cardioplegic ischemia in immature rabbit hearts.
Topics: Animals; Animals, Newborn; Biomarkers; Blotting, Western; Cardioplegic Solutions; Carrier Proteins; | 2000 |
Effects of fasting and exogenous glucose delivery on cardiac tolerance to low-flow ischemia in adult and senescent rats.
Topics: Aging; Animals; Coronary Circulation; Energy Metabolism; Fasting; Glucose; Glycogen; Glycolysis; In | 2000 |
Mechanism of Ca(2+) overload in endothelial cells exposed to simulated ischemia.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Calcium; Calcium Channel Blockers; Cell Size; | 2000 |
Acute diabetes modulates response to ischemia in isolated rat heart.
Topics: Animals; Arrhythmias, Cardiac; Blood Glucose; Diabetes Mellitus, Experimental; Glycogen; Heart; Hear | 2000 |
Antioxidant pyruvate inhibits cardiac formation of reactive oxygen species through changes in redox state.
Topics: Animals; Antioxidants; Coumaric Acids; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guinea P | 2000 |
Glycogen turnover and anaplerosis in preconditioned rat hearts.
Topics: Alanine; Animals; Citric Acid Cycle; Glutamic Acid; Glycogen; Heart; Hydrogen-Ion Concentration; In | 2000 |
Myocardial ischemia during physical exercise in patients with stable coronary artery disease: predictability and prevention.
Topics: Coronary Angiography; Coronary Disease; Exercise Test; Exercise Therapy; Female; Heart Rate; Humans; | 2000 |
Metabolic support as an adjunct to inotropic support in the hypoperfused heart.
Topics: Adenosine Triphosphate; Animals; Blood Flow Velocity; Blood Pressure; Dobutamine; Electrophysiology; | 2001 |
The effect of K(atp)channel activation on myocardial cationic and energetic status during ischemia and reperfusion: role in cardioprotection.
Topics: Adenosine Triphosphate; Animals; Cations; Energy Metabolism; Lactic Acid; Male; Myocardial Ischemia; | 2001 |
Effect of NaHCO3 on cardiac energy metabolism and contractile function during hypoxemia.
Topics: Acidosis, Lactic; Analysis of Variance; Animals; Blood Gas Analysis; Disease Models, Animal; Dogs; D | 2001 |
Ventricular arrhythmias following coronary artery occlusion in rats: is the diabetic heart less or more sensitive to ischaemia?
Topics: Animals; Blood Glucose; Coronary Disease; Diabetes Mellitus, Experimental; Glycogen; In Vitro Techni | 2001 |
An ultrafiltration catheter for monitoring of venous lactate and glucose around myocardial ischemia.
Topics: Animals; Biosensing Techniques; Blood Glucose; Catheterization; Coronary Vessels; Lactic Acid; Monit | 2001 |
Ischemic-reperfused isolated working mouse hearts: membrane damage and type IIA phospholipase A2.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Cardiac Output; Cell Membrane; Fatty Acids; Fe | 2001 |
Protection of ischemic hearts by high glucose is mediated, in part, by GLUT-4.
Topics: Animals; Creatine Kinase; Cytochalasin B; Dose-Response Relationship, Drug; Glucose; Glucose Transpo | 2001 |
Responses of GLUT4-deficient hearts to ischemia underscore the importance of glycolysis.
Topics: Adenosine Triphosphate; Animals; Blood Pressure; Creatine; Fasting; Glucose; Glucose Transporter Typ | 2001 |
Toward a better understanding of the metabolic effects of ischemic preconditioning in humans.
Topics: Animals; Coronary Artery Bypass; Humans; Ischemic Preconditioning, Myocardial; Lactic Acid; Myocardi | 2001 |
ET-1 levels in cardioischemic patients undergoing atrial pacing.
Topics: Adult; Cardiac Pacing, Artificial; Case-Control Studies; Coronary Circulation; Endothelin-1; Humans; | 2001 |
Evidence of functional myocardial ischemia associated with myocardial dysfunction in brain-dead pigs.
Topics: Adenosine; Animals; Blood Flow Velocity; Blood Gas Analysis; Blood Pressure; Brain Death; Cardiac Ou | 2001 |
A versatile biosensor device for continuous biomedical monitoring.
Topics: Animals; Biosensing Techniques; Blood Glucose; Glucose Tolerance Test; Humans; Lactic Acid; Microdia | 2001 |
Pre-conditioning activates adenosine utilization in a cost-effective way during myocardial ischaemia.
Topics: Adenosine; Animals; Deoxyadenosines; Female; Glycolysis; Inosine; Ischemic Preconditioning, Myocardi | 2001 |
Myocardial metabolism of 123I-BMIPP during low-flow ischaemia in an experimental model: comparison with myocardial blood flow and 18F-FDG.
Topics: Animals; Coronary Circulation; Fatty Acids; Fluorodeoxyglucose F18; Iodine Radioisotopes; Iodobenzen | 2001 |
Myocardial metabolism of exogenous FDP is consistent with transport by a dicarboxylate transporter.
Topics: Animals; Anion Exchange Protein 1, Erythrocyte; Biological Transport; Carbon Dioxide; Carbon Radiois | 2001 |
Application of C1-esterase inhibitor during reperfusion of ischemic myocardium: dose-related beneficial versus detrimental effects.
Topics: Anaphylatoxins; Animals; Blood Gas Analysis; Cardiac Output; Complement C1 Inactivator Proteins; Cor | 2001 |
N-methyl-1-deoxynojirimycin (MOR-14), an alpha-glucosidase inhibitor, markedly improves postischemic left ventricular dysfunction.
Topics: 1-Deoxynojirimycin; Adenosine Triphosphate; Animals; Blood Flow Velocity; Disease Models, Animal; En | 2000 |
Intraoperative metabolic monitoring of the heart: I. Clinical assessment of coronary sinus metabolites.
Topics: Energy Metabolism; Heart Arrest, Induced; Heart Diseases; Humans; Intraoperative Complications; Lact | 2001 |
Myocardial ischemia recruits mechanically insensitive cardiac sympathetic afferents in cats.
Topics: Action Potentials; Animals; Bradykinin; Cats; Female; Heart; Lactic Acid; Male; Myocardial Ischemia; | 2002 |
Endogenous nitric oxide prevents myocardial ischemia in patients with hypertension and left ventricular hypertrophy.
Topics: Aged; Cardiac Catheterization; Coronary Circulation; Enzyme Inhibitors; Female; Humans; Hypertension | 2002 |
Myocardial ischemia induces coronary t-PA release in the pig.
Topics: Animals; Blood Flow Velocity; Coronary Circulation; Coronary Vessels; Enzyme-Linked Immunosorbent As | 2002 |
Lactate accumulation rather than ATP depletion predicts ischemic myocardial necrosis: implications for the development of lethal myocardial injury.
Topics: Adenosine Triphosphate; Animals; Disease Models, Animal; Lactic Acid; Myocardial Ischemia; Myocardiu | 2002 |
Increased nonoxidative glycolysis despite continued fatty acid uptake during demand-induced myocardial ischemia.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Blood Flow Velocity; Coronary Vessels; Dobut | 2002 |
Mechanistic model of myocardial energy metabolism under normal and ischemic conditions.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Blood Glucose; Computer Simulation; Coronary | 2002 |
Protective effects of protein kinase C during myocardial ischemia require activation of phosphatidyl-inositol specific phospholipase C.
Topics: Adenosine Triphosphate; Alkaloids; Animals; Benzophenanthridines; Blotting, Western; Calcium; Corona | 2002 |
Monitoring of porcine myocardial ischemia and reperfusion by intravasal microdialysis.
Topics: Animals; Biomarkers; Blood Glucose; Disease Models, Animal; Female; Glutamic Acid; Glycerol; Hemodyn | 2002 |
Evaluation of a new ultrasound contrast agent (AI-700) using two-dimensional and three-dimensional imaging during acute ischemia.
Topics: Animals; Contrast Media; Disease Models, Animal; Dogs; Echocardiography, Three-Dimensional; Fluoroca | 2002 |
Chemical mediators of the muscle ergoreflex in chronic heart failure: a putative role for prostaglandins in reflex ventilatory control.
Topics: Aged; Aspirin; Bradykinin; Chemoreceptor Cells; Chronic Disease; Cyclooxygenase Inhibitors; Exercise | 2002 |
Myocardial metabolism and adaptation during extreme hemodilution in humans after coronary revascularization.
Topics: Blood Transfusion, Autologous; Catheterization, Swan-Ganz; Coronary Artery Bypass; Electrocardiograp | 1992 |
Effects of duration of ischaemia during preconditioning on mechanical function, enzyme release and energy production in the isolated working rat heart.
Topics: Adenine Nucleotides; Animals; Creatine Kinase; Energy Metabolism; Glycogen; Heart; In Vitro Techniqu | 1992 |
Assessment of myocardial oxygen consumption (Vo2) and systolic pressure-volume area (PVA) in human hearts.
Topics: Angina Pectoris; Blood Pressure; Blood Volume; Cardiac Catheterization; Cardiac Volume; Computer Gra | 1992 |