lactic acid has been researched along with Muscle Weakness in 19 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Muscle Weakness: A vague complaint of debility, fatigue, or exhaustion attributable to weakness of various muscles. The weakness can be characterized as subacute or chronic, often progressive, and is a manifestation of many muscle and neuromuscular diseases. (From Wyngaarden et al., Cecil Textbook of Medicine, 19th ed, p2251)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The long-term effects of the sodium salt of dichloroacetic acid (DCA) were evaluated in four patients with mitochondrial encephalomyelopathy with lactic acidosis and stroke-like episodes (MELAS) carrying A3243G mutation." | 5.11 | Dichloroacetate treatment for mitochondrial cytopathy: long-term effects in MELAS. ( Goto, T; Momoi, MY; Mori, M; Saito, S; Yamagata, T, 2004) |
| "Three unrelated, sporadic patients with muscle coenzyme Q10 (CoQ10) deficiency presented at 32, 29, and 6 years of age with proximal muscle weakness and elevated serum creatine kinase (CK) and lactate levels, but without myoglobinuria, ataxia, or seizures." | 3.73 | Coenzyme Q10 deficiency and isolated myopathy. ( DiMauro, S; Gempel, K; Horvath, R; Lochmüller, H; Müller-Höcker, J; Naini, A; Neuen-Jacob, E; Plöger, H; Pongratz, DE; Schneiderat, P; Schoser, BG, 2006) |
| "Patients with mitochondrial myopathies (MM) usually suffer from exercise intolerance due to their impaired oxidative capacity and physical deconditioning." | 2.71 | Exercise training in mitochondrial myopathy: a randomized controlled trial. ( Arenas, J; Bautista, J; Campos, Y; Cejudo, P; Jiménez, L; Montemayor, T; Ortega, F; Sánchez, H; Villagómez, R, 2005) |
| "Inherited ataxias are a group of heterogeneous disorders in children or adults but their genetic definition remains still undetermined in almost half of the patients." | 1.43 | Cerebellar ataxia and severe muscle CoQ10 deficiency in a patient with a novel mutation in ADCK3. ( Barca, E; DiMauro, S; Granata, F; Marino, S; Montagnese, F; Musumeci, O; Nunnari, D; Peverelli, L; Quinzii, CM; Toscano, A, 2016) |
| "PDHc deficiency was demonstrated in muscle and fibroblasts without detectable PDHA1 mutations." | 1.36 | Dihydrolipoamide dehydrogenase (DLD) deficiency in a Spanish patient with myopathic presentation due to a new mutation in the interface domain. ( Briones, P; Font, A; Pineda, M; Quintana, E; Ribes, A; Tort, F; Vilaseca, MA, 2010) |
| "Both patients had PDH deficiency caused by a new mutation (G585C) in the PDHA1 gene, which is predicted to replace a highly conserved glycine at codon 195 by alanine." | 1.35 | Pyruvate dehydrogenase deficiency presenting as intermittent isolated acute ataxia. ( Debray, FG; Gagne, R; Laframboise, R; Lambert, M; MacKay, N; Maranda, B; Mitchell, GA; Robinson, BH, 2008) |
| "The lack of cobalamin caused a severe encephalopathy in the infant, whose brain displayed a striking loss of volume and a delay of myelination." | 1.32 | Infantile cobalamin deficiency with cerebral lactate accumulation and sustained choline depletion. ( Horstmann, M; Kohlschütter, A; Lukacs, Z; Neumaier-Probst, E; Steinfeld, R; Ullrich, K, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (10.53) | 18.2507 |
| 2000's | 10 (52.63) | 29.6817 |
| 2010's | 6 (31.58) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Hiraki, N | 1 |
| Tanaka, TD | 1 |
| Yoshimura, M | 1 |
| Baldanzi, S | 1 |
| Ricci, G | 1 |
| Bottari, M | 1 |
| Chico, L | 1 |
| Simoncini, C | 1 |
| Siciliano, G | 1 |
| Lee, BK | 1 |
| Cho, IS | 1 |
| Oh, JS | 1 |
| Choi, WJ | 1 |
| Wee, JH | 1 |
| Kim, CS | 1 |
| Kim, WY | 1 |
| Youn, CS | 1 |
| Barca, E | 1 |
| Musumeci, O | 1 |
| Montagnese, F | 1 |
| Marino, S | 1 |
| Granata, F | 1 |
| Nunnari, D | 1 |
| Peverelli, L | 1 |
| DiMauro, S | 3 |
| Quinzii, CM | 1 |
| Toscano, A | 1 |
| Quintana, E | 1 |
| Pineda, M | 1 |
| Font, A | 1 |
| Vilaseca, MA | 1 |
| Tort, F | 1 |
| Ribes, A | 1 |
| Briones, P | 1 |
| Liu, S | 1 |
| Lee, YF | 1 |
| Chou, S | 1 |
| Uno, H | 1 |
| Li, G | 1 |
| Brookes, P | 1 |
| Massett, MP | 1 |
| Wu, Q | 1 |
| Chen, LM | 1 |
| Chang, C | 1 |
| Jakkani, R | 1 |
| Jyoti, S | 1 |
| Ahmed, M | 1 |
| Thomas, MM | 1 |
| Horstmann, M | 1 |
| Neumaier-Probst, E | 1 |
| Lukacs, Z | 1 |
| Steinfeld, R | 1 |
| Ullrich, K | 1 |
| Kohlschütter, A | 1 |
| Mori, M | 1 |
| Yamagata, T | 1 |
| Goto, T | 1 |
| Saito, S | 1 |
| Momoi, MY | 1 |
| Lalani, SR | 1 |
| Vladutiu, GD | 1 |
| Plunkett, K | 1 |
| Lotze, TE | 1 |
| Adesina, AM | 1 |
| Scaglia, F | 1 |
| Cejudo, P | 1 |
| Bautista, J | 1 |
| Montemayor, T | 1 |
| Villagómez, R | 1 |
| Jiménez, L | 1 |
| Ortega, F | 1 |
| Campos, Y | 1 |
| Sánchez, H | 1 |
| Arenas, J | 1 |
| Horvath, R | 1 |
| Schneiderat, P | 1 |
| Schoser, BG | 1 |
| Gempel, K | 1 |
| Neuen-Jacob, E | 1 |
| Plöger, H | 1 |
| Müller-Höcker, J | 1 |
| Pongratz, DE | 1 |
| Naini, A | 1 |
| Lochmüller, H | 1 |
| Ørngreen, MC | 1 |
| Schelhaas, HJ | 1 |
| Jeppesen, TD | 1 |
| Akman, HO | 1 |
| Wevers, RA | 1 |
| Andersen, ST | 1 |
| ter Laak, HJ | 1 |
| van Diggelen, OP | 1 |
| Vissing, J | 1 |
| Debray, FG | 1 |
| Lambert, M | 1 |
| Gagne, R | 1 |
| Maranda, B | 1 |
| Laframboise, R | 1 |
| MacKay, N | 1 |
| Robinson, BH | 1 |
| Mitchell, GA | 1 |
| Cohen, O | 1 |
| Steiner, I | 1 |
| Argov, Z | 1 |
| Ashkenazi, A | 1 |
| Diment, J | 1 |
| Saada, A | 1 |
| River, Y | 1 |
| Gleeson, M | 1 |
| Blannin, AK | 1 |
| Walsh, NP | 1 |
| Field, CN | 1 |
| Pritchard, JC | 1 |
| McLoughlin, DM | 1 |
| Wassif, WS | 1 |
| Morton, J | 1 |
| Spargo, E | 1 |
| Peters, TJ | 1 |
| Russell, GF | 1 |
| Casaburi, R | 1 |
| Izquierdo, M | 1 |
| Häkkinen, K | 1 |
| Antón, A | 1 |
| Garrues, M | 1 |
| Ibañez, J | 1 |
| Ruesta, M | 1 |
| Gorostiaga, EM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Triheptanoin's Effect on Fatty Acid Oxidation and Exercise Tolerance in Patients With Debrancher Deficiency, Glycogenin-1 Deficiency and Phosphofructoinase Deficiency at Rest and During Exercise. A Randomized, Double-blind, Placebo-controlled, Cross-over [NCT03642860] | Phase 2 | 3 participants (Actual) | Interventional | 2018-08-15 | Terminated (stopped due to Problems with recruitment) | ||
| Regulation of Nitric Oxide Bioavailability in Chronic Obstructive Pulmonary Disease: A Mechanistic Approach[NCT01398943] | 60 participants (Actual) | Interventional | 2010-09-30 | Completed | |||
| Effects of Smartphone Usage Duration on Neck Dysfunction in Young Versus Middle Aged Patients With Chronic Mechanical Neck Pain[NCT03745469] | 80 participants (Actual) | Observational | 2018-11-20 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Brachial artery FMD induced by reactive hyperemia will be used to assess vascular endothelial function at baseline and several hours after each experimental intervention. (NCT01398943)
Timeframe: Post FMD was taken approximately 110 min after baseline
| Intervention | percentage of change in FMD (Mean) | |
|---|---|---|
| Placebo | AOC Treatment | |
| All Controls | 6.7 | 6.9 |
| All COPD Patients | 3.1 | 4.7 |
A measure of vascular stiffness at baseline and several hours after each experimental intervention. (NCT01398943)
Timeframe: Post PWV was taken approximately 90 min after baseline
| Intervention | m/sec (Mean) | |
|---|---|---|
| Placebo | AOC Treatment | |
| All Controls | 11 | 10 |
| All COPD Patients | 14 | 11 |
1 review available for lactic acid and Muscle Weakness
| Article | Year |
|---|---|
Skeletal muscle function in COPD.
Topics: Anabolic Agents; Biomechanical Phenomena; Dyspnea; Exercise Therapy; Humans; Lactic Acid; Lung Disea | 2000 |
3 trials available for lactic acid and Muscle Weakness
| Article | Year |
|---|---|
Continuous neuromuscular blockade infusion for out-of-hospital cardiac arrest patients treated with targeted temperature management: A multicenter randomized controlled trial.
Topics: Aged; Biomarkers; Female; Humans; Hypothermia, Induced; Lactic Acid; Length of Stay; Male; Middle Ag | 2018 |
Dichloroacetate treatment for mitochondrial cytopathy: long-term effects in MELAS.
Topics: Abdominal Pain; Administration, Oral; Adolescent; Chemical and Drug Induced Liver Injury; Child; Dic | 2004 |
Exercise training in mitochondrial myopathy: a randomized controlled trial.
Topics: Adolescent; Adult; Aged; Exercise; Exercise Therapy; Exercise Tolerance; Female; Humans; Lactic Acid | 2005 |
15 other studies available for lactic acid and Muscle Weakness
| Article | Year |
|---|---|
A Man With Left Ventricular Hypertrophy.
Topics: Adult; Atrophy; Cardiomyopathies; Cerebellar Diseases; Cognitive Dysfunction; Echocardiography; Gluc | 2022 |
The proposal of a clinical protocol to assess central and peripheral fatigue in myotonic dystrophy type 1.
Topics: Adult; Advanced Oxidation Protein Products; Aged; Attention; Case-Control Studies; Clinical Protocol | 2017 |
Cerebellar ataxia and severe muscle CoQ10 deficiency in a patient with a novel mutation in ADCK3.
Topics: Ataxia; Cerebellar Ataxia; Codon, Nonsense; Delayed Diagnosis; Electron Transport Chain Complex Prot | 2016 |
Dihydrolipoamide dehydrogenase (DLD) deficiency in a Spanish patient with myopathic presentation due to a new mutation in the interface domain.
Topics: Acidosis, Lactic; Adult; Amino Acid Sequence; Base Sequence; Biomarkers; Blepharoptosis; Cells, Cult | 2010 |
Mice lacking TR4 nuclear receptor develop mitochondrial myopathy with deficiency in complex I.
Topics: Adenosine Triphosphate; Aminoimidazole Carboxamide; Animals; Cells, Cultured; Electron Transport Com | 2011 |
Magnetic resonance imaging findings in adult-form myotonic dystrophy type 1.
Topics: Adult; Atrophy; Brain; Cataract; Central Nervous System; Electromyography; Hearing Disorders; Humans | 2012 |
Infantile cobalamin deficiency with cerebral lactate accumulation and sustained choline depletion.
Topics: Brain Diseases; Choline Deficiency; Humans; Infant; Lactic Acid; Magnetic Resonance Spectroscopy; Ma | 2003 |
Isolated mitochondrial myopathy associated with muscle coenzyme Q10 deficiency.
Topics: Biopsy; Child; Coenzymes; Creatine Kinase; DNA, Mitochondrial; Electron Transport; Humans; Lactic Ac | 2005 |
Coenzyme Q10 deficiency and isolated myopathy.
Topics: Adult; Coenzymes; Creatine Kinase; Delivery, Obstetric; Disease Progression; Electron Transport Comp | 2006 |
Is muscle glycogenolysis impaired in X-linked phosphorylase b kinase deficiency?
Topics: Chromosomes, Human, X; Exercise Test; Glycogen; Glycogen Storage Disease Type V; Glycogen Storage Di | 2008 |
Pyruvate dehydrogenase deficiency presenting as intermittent isolated acute ataxia.
Topics: Ataxia; Basal Ganglia Diseases; Binding Sites; Brain Diseases, Metabolic; Child; Child, Preschool; D | 2008 |
Mitochondrial myopathy with atypical subacute presentation.
Topics: Acute Disease; Adult; Biopsy; Disease Progression; Electromyography; Female; Humans; Lactic Acid; Mi | 1998 |
Effect of exercise-induced muscle damage on the blood lactate response to incremental exercise in humans.
Topics: Adult; Bicycling; Creatine Kinase; Exercise; Female; Humans; Lactic Acid; Male; Muscle Weakness; Mus | 1998 |
Metabolic abnormalities associated with skeletal myopathy in severe anorexia nervosa.
Topics: Adolescent; Adult; Anemia; Anorexia Nervosa; Dipeptidases; Exercise; Female; Follicle Stimulating Ho | 2000 |
Maximal strength and power, endurance performance, and serum hormones in middle-aged and elderly men.
Topics: Adult; Aged; Aging; Bicycling; Biomechanical Phenomena; Energy Metabolism; Humans; Hydrocortisone; L | 2001 |