Page last updated: 2024-10-17

lactic acid and Muscle Disorders

lactic acid has been researched along with Muscle Disorders in 55 studies

Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.

Research Excerpts

ExcerptRelevanceReference
"We report on a patient, now 17 year old, in whom lactic acidosis was detected at the age of 7 while attempting to diagnose the causes of increasing weakness."7.67[Lactic acid acidosis with mitochondrial myopathy due to a pyruvate dehydrogenase deficiency]. ( Dworschak, E; Hammerer, I; Höpfel, I; Maurer, H; Sperl, W, 1985)
"Three unrelated, sporadic patients with muscle coenzyme Q10 (CoQ10) deficiency presented at 32, 29, and 6 years of age with proximal muscle weakness and elevated serum creatine kinase (CK) and lactate levels, but without myoglobinuria, ataxia, or seizures."3.73Coenzyme Q10 deficiency and isolated myopathy. ( DiMauro, S; Gempel, K; Horvath, R; Lochmüller, H; Müller-Höcker, J; Naini, A; Neuen-Jacob, E; Plöger, H; Pongratz, DE; Schneiderat, P; Schoser, BG, 2006)
"Aluminum lactate, injected in rats, produced skeletal muscle necrosis of diaphragm and abdominal wall subjacent to peritoneal surfaces."3.68Parenteral aluminum compounds produce a local toxic myopathy in rats: importance of the anion. ( Drakontides, AB; Levine, S; Saltzman, A, 1992)
"We report on a patient, now 17 year old, in whom lactic acidosis was detected at the age of 7 while attempting to diagnose the causes of increasing weakness."3.67[Lactic acid acidosis with mitochondrial myopathy due to a pyruvate dehydrogenase deficiency]. ( Dworschak, E; Hammerer, I; Höpfel, I; Maurer, H; Sperl, W, 1985)
" At the dosage of CoQ10 used in the study (2 mg/kg/day) the therapy requires long administration time before a response is demonstrable."2.67Multicenter trial with ubidecarenone: treatment of 44 patients with mitochondrial myopathies. ( Angelini, C; Bresolin, N; Carenzi, A; Castelli, E; Comi, G; Doriguzzi, C; Moroni, I; Scarlato, G, 1991)
"Atorvastatin treatment resulted in a rise in both CK (2X) and myoglobin (6X) level with graded degrees of muscle necrosis."1.43Elucidation of the mechanism of atorvastatin-induced myopathy in a rat model. ( Abdallah, D; El-Ganainy, SO; El-Khatib, AS; El-Mallah, A; Khattab, MM; Mohy El-Din, MM, 2016)
"Three patients with chronic progressive external ophthalmoplegia of adult-onset, generalized muscle atrophy and myalgia are described."1.29Mitochondrial dysfunction in adult-onset myopathies with structural abnormalities. ( Gold, R; Klopstock, T; Naumann, M; Paulus, W; Reichmann, H; Reiners, K; Schindler, R, 1995)
"The CT scan showed multiple intracerebral infarcts, basal ganglia calcifications, and cerebral atrophy."1.28[Mitochondrial encephalomyopathy. Report of a case]. ( Chen, Q, 1990)
"The carnitine concentration was diminished in blood and muscle tissue."1.27Mitochondrial myopathy with lactic acidaemia, Fanconi-De Toni-Debré syndrome and a disturbed succinate: cytochrome c oxidoreductase activity. ( Guggenbichler, JP; Ruitenbeek, W; Sengers, RC; Sperl, W; Stadhouders, AM; Trijbels, JM, 1988)

Research

Studies (55)

TimeframeStudies, this research(%)All Research%
pre-19908 (14.55)18.7374
1990's13 (23.64)18.2507
2000's16 (29.09)29.6817
2010's17 (30.91)24.3611
2020's1 (1.82)2.80

Authors

AuthorsStudies
Gkiourtzis, N1
Tramma, D1
Papadopoulou-Legbelou, K1
Moutafi, M1
Evangeliou, A1
Malila, Y1
Thanatsang, K1
Arayamethakorn, S1
Uengwetwanit, T1
Srimarut, Y1
Petracci, M1
Strasburg, GM1
Rungrassamee, W1
Visessanguan, W1
Riley, MS1
Nicholls, DP1
Cooper, CB2
Leung, YH1
Belanger, F1
Lu, J1
Turgeon, J1
Michaud, V1
Semeraro, M1
Boenzi, S1
Carrozzo, R1
Diodato, D1
Martinelli, D1
Olivieri, G1
Antonetti, G1
Sacchetti, E1
Catesini, G1
Rizzo, C1
Dionisi-Vici, C1
Vissing, J4
Akman, HO1
Aasly, J1
Kahler, SG1
Bacino, CA1
DiMauro, S2
Haller, RG1
Preisler, N1
Laforêt, P1
Echaniz-Laguna, A1
Ørngreen, MC3
Lonsdorfer-Wolf, E1
Doutreleau, S1
Geny, B1
Stojkovic, T1
Piraud, M1
Petit, FM1
Oishi, Y1
Tsukamoto, H1
Yokokawa, T1
Hirotsu, K1
Shimazu, M1
Uchida, K1
Tomi, H1
Higashida, K1
Iwanaka, N1
Hashimoto, T1
El-Ganainy, SO1
El-Mallah, A1
Abdallah, D1
Khattab, MM1
Mohy El-Din, MM1
El-Khatib, AS1
Castagnaro, S1
Pellegrini, C1
Pellegrini, M1
Chrisam, M1
Sabatelli, P1
Toni, S1
Grumati, P1
Ripamonti, C1
Pratelli, L1
Maraldi, NM1
Cocchi, D1
Righi, V1
Faldini, C1
Sandri, M1
Bonaldo, P1
Merlini, L1
Dolezal, BA1
Neufeld, EV1
Shieh, P1
Jenner, JR1
Riley, M1
Saxena, S2
Shukla, D1
Khan, YA1
Singh, M1
Bansal, A1
Sairam, M1
Jain, SK1
Flodgren, GM1
Crenshaw, AG1
Hellström, F1
Fahlström, M1
Mykkänen, AK1
Koho, NM1
Reeben, M1
McGowan, CM1
Pösö, AR1
Carrasco, L1
Sañudo, B1
de Hoyo, M1
Pradas, F1
Da Silva, ME1
Mouadil, A1
Debout, C1
Read, MH1
Morello, R1
Allouche, S1
Chapon, F1
Yoon, YA1
Lee, DH1
Ki, CS1
Lee, SY1
Kim, JW1
Lee, YW1
Park, HD1
Ernberg, M1
Castrillon, EE1
Ghafouri, B1
Larsson, B1
Gerdle, B1
List, T1
Svensson, P1
Lindner, A1
ISRAELS, S1
HAWORTH, JC1
GOURLEY, B1
FORD, JD1
Lane, RJ1
Soteriou, BA1
Zhang, H1
Archard, LC1
Nørgaard, MG1
Sacchetti, M2
van Engelen, BG1
Dunø, M1
Ejstrup, R1
Christensen, E1
Schwartz, M1
Horvath, R1
Schneiderat, P1
Schoser, BG1
Gempel, K1
Neuen-Jacob, E1
Plöger, H1
Müller-Höcker, J1
Pongratz, DE1
Naini, A1
Lochmüller, H1
Hanisch, F1
Eger, K1
Bork, S1
Lehnich, H1
Deschauer, M1
Zierz, S1
Bröjer, JT1
Essén-Gustavsson, B1
Annandale, EJ1
Valberg, SJ1
Sattler, UG1
Walenta, S1
Mueller-Klieser, W1
Jubeau, M1
Sartorio, A1
Marinone, PG1
Agosti, F1
Van Hoecke, J1
Nosaka, K1
Maffiuletti, NA1
Tricarico, D1
Lovaglio, S1
Mele, A1
Rotondo, G1
Mancinelli, E1
Meola, G1
Camerino, DC1
Westermann, CM1
Dorland, L1
Votion, DM1
de Sain-van der Velden, MG1
Wijnberg, ID1
Wanders, RJ1
Spliet, WG1
Testerink, N1
Berger, R1
Ruiter, JP1
van der Kolk, JH1
Fishbein, WN1
Naumann, M1
Reiners, K1
Gold, R1
Schindler, R1
Paulus, W1
Klopstock, T1
Reichmann, H1
Wassif, WS2
Sherman, D1
Salisbury, JR1
Peters, TJ2
Gross, M2
Gresser, U2
Brazeau, GA1
Sciame, M1
al-Suwayeh, SA1
Fattal, E1
Platt, SR1
Chrisman, CL1
Shelton, GD1
Taivassalo, T1
De Stefano, N1
Chen, J1
Karpati, G1
Arnold, DL1
Argov, Z1
Riggs, JE1
Schochet, SS1
Webb, RW1
McLoughlin, DM1
Morton, J1
Spargo, E1
Russell, GF1
Belardinelli, R1
Hickner, RC1
Mehta, PM1
Dyck, D1
Devita, P1
Houmard, JA1
Koves, T1
Byrd, P1
Nonaka, I1
Koch, HJ1
Uyanik, G1
Raschka, C1
Levine, S1
Saltzman, A1
Drakontides, AB1
Wagner, DR1
Kamilli, I1
Zöllner, N1
Scarlato, G1
Bresolin, N2
Moroni, I2
Doriguzzi, C2
Castelli, E2
Comi, G1
Angelini, C2
Carenzi, A1
Ponzetto, C1
Cossutta, E1
Binda, A1
Gallanti, A1
Gabellini, S1
de Barsy, T1
Hers, HG1
Chen, Q1
Sperl, W2
Ruitenbeek, W1
Trijbels, JM1
Sengers, RC1
Stadhouders, AM1
Guggenbichler, JP1
Yokochi, K1
Tatsumi, C1
Takahashi, M1
Yorifuji, S1
Nishikawa, Y1
Kitaguchi, M1
Hashimoto, S1
Tarui, S1
Petty, RK1
Harding, AE1
Morgan-Hughes, JA1
Bogaard, JM1
Busch, HF1
Arts, WF1
Heijsteeg, M1
Stam, H1
Versprille, A1
Maurer, H1
Dworschak, E1
Höpfel, I1
Hammerer, I1

Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Blood Flow Restriction Training for The Shoulder: A Case for Proximal Benefit[NCT04540367]32 participants (Actual)Interventional2017-11-10Completed
Low Protein Diet to Correct Defective Autophagy in Patients With Collagen VI Related Myopathies[NCT01438788]Phase 28 participants (Actual)Interventional2011-10-31Completed
Triheptanoin's Effect on Fatty Acid Oxidation and Exercise Tolerance in Patients With Debrancher Deficiency, Glycogenin-1 Deficiency and Phosphofructoinase Deficiency at Rest and During Exercise. A Randomized, Double-blind, Placebo-controlled, Cross-over [NCT03642860]Phase 23 participants (Actual)Interventional2018-08-15Terminated (stopped due to Problems with recruitment)
Fat and Sugar Metabolism During Exercise in Patients With Metabolic Myopathy[NCT02635269]60 participants (Actual)Interventional2016-01-31Active, not recruiting
Phase 3 Trial of Coenzyme Q10 in Mitochondrial Disease[NCT00432744]Phase 324 participants (Actual)Interventional2007-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

McMaster Gross Motor Function (GMFM 88)

The McMaster Gross Motor Function is a validated scale ranging from 0 to 100 (the higher the better). Since there was the possibility of a subject becoming totally disabled our FDA peer reviewed design called for its use as follows: If the subject completed both periods, the score was calculated as the difference in scores between the end of Period 2 (at 12 months) minus that at the end of Period 1 (6 months). If a subject became totally disabled, this difference was considered as plus infinity if it occurred in period 1 (Penalizes period 1), and minus infinity if it occurred in Period 2 (Penalizes period 2). The two treatments were compared via the Wilcoxon test, and the effect size was estimated using Kendall's Tau-B. This is interpreted in a similar manner to correlation with positive values favoring COQenzyme10 and negative values favoring placebo. One of the links in this report is to the the GMFM scale and how it is scored. A link to the instrument is included. (NCT00432744)
Timeframe: Taken at 6 and 12 Months

Interventionunits on a scale (Median)
Placebo First-0.002
CoenzymeQ10 Frist-0.12

Non-parametric Hotelling T-square Bivariate Analysis of GMGF 88 and OPeds QOL.

This is a multivariate analysis of the first two outcomes: Period 2 minus Period 1 GMFM88 and Peds Quality of Life, analyzed as follows: First, to be in the analysis, subjects must contribute at least one of these endpoints. Second, if the subject became totally disabled during period 1, the difference was defined as + infinity, (highest possible evidence favoring period 2), and if the subject became totally disabled in period 2, the subject was scored as - infinity (highest possible evidence favoring period 1). Period 2 minus period 1 differences were ranked form low to high with missing values scores at the mid-rank. The Hotelling T-square was computed on these ranks and the P-value was obtained from 100,000 rerandomizations as the fraction of rerandomizations with T-sq at least as large as that observed. (NCT00432744)
Timeframe: end of 12 month minus end of 6 month difference.

Interventionparticipants (Number)
Placebo First7
CoenzymeQ10 Frist8

Pediatric Quality of Life Scale

"The Pediatric Quality of Life Scale is a validated scale ranging from 0 to 100 (the higher the better). Since there was the possibility of a subject becoming totally disabled our FDA peer reviewed design called for its use as follows: If the subject completed both periods, the score was calculated as the difference in scores between the end of Period 2 (at 12 months) minus that at the end of Period 1 (6 months). If a subject became totally disabled, this difference was considered as plus infinity if it occurred in period 1 (Penalizes period 1), and minus infinity if it occurred in Period 2 (Penalizes period 2). The two treatments were compared via the Wilcoxon test, and the effect size was estimated using Kendall's Tau-B. This is interpreted in a similar manner to correlation with positive values favoring COQenzyme10 and negative values favoring placebo. Goggle pedsQL and Mapi to browse the copyrighted manual. A link to the instrument is included." (NCT00432744)
Timeframe: At 6 and 12 Months

Interventionunits on a scale (Median)
Placebo First-1.1
CoenzymeQ10 Frist-11.9

Reviews

4 reviews available for lactic acid and Muscle Disorders

ArticleYear
Cardiopulmonary Exercise Testing and Metabolic Myopathies.
    Annals of the American Thoracic Society, 2017, Volume: 14, Issue:Supplement

    Topics: Carbon Dioxide; Exercise Test; Exercise Tolerance; Humans; Lactic Acid; Muscular Diseases; Oxidative

2017
[Physiopathology of exercise. Muscular adaptations].
    Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology, 2000, Volume: 1, Issue:3

    Topics: Adaptation, Physiological; Anaerobic Threshold; Biopsy; Exercise; Exercise Test; Exercise Tolerance;

2000
[Complex II (succinate-ubiquinone reductase) deficiency].
    Ryoikibetsu shokogun shirizu, 2001, Issue:36

    Topics: Electron Transport; Electron Transport Complex II; Genes, Recessive; Humans; Lactic Acid; Leigh Dise

2001
Normal metabolism and disorders of carbohydrate metabolism.
    Bailliere's clinical endocrinology and metabolism, 1990, Volume: 4, Issue:3

    Topics: Carbohydrate Metabolism; Enzymes; Glucose; Glycogen; Glycogen Storage Disease; Glycolysis; Humans; L

1990

Trials

10 trials available for lactic acid and Muscle Disorders

ArticleYear
Autophagy activation in COL6 myopathic patients by a low-protein-diet pilot trial.
    Autophagy, 2016, Volume: 12, Issue:12

    Topics: Adult; Alanine; Autophagy; Biomarkers; Biopsy; Body Composition; Collagen Type VI; Contracture; Diet

2016
Combining microdialysis and near-infrared spectroscopy for studying effects of low-load repetitive work on the intramuscular chemistry in trapezius myalgia.
    Journal of biomedicine & biotechnology, 2010, Volume: 2010

    Topics: Adiposity; Adult; Female; Glutamic Acid; Humans; Lactic Acid; Microdialysis; Muscle, Skeletal; Muscu

2010
Effectiveness of low-frequency vibration recovery method on blood lactate removal, muscle contractile properties and on time to exhaustion during cycling at VO₂max power output.
    European journal of applied physiology, 2011, Volume: 111, Issue:9

    Topics: Adult; Bicycling; Exercise Test; Humans; Lactic Acid; Male; Muscle Contraction; Muscle Strength; Mus

2011
Experimental myalgia induced by repeated infusion of acidic saline into the human masseter muscle does not cause the release of algesic substances.
    European journal of pain (London, England), 2013, Volume: 17, Issue:4

    Topics: Acids; Adult; Female; Glucose; Glutamic Acid; Humans; Hyperalgesia; Lactic Acid; Male; Masseter Musc

2013
Lactate production upon short-term non-ischemic forearm exercise in mitochondrial disorders and other myopathies.
    Journal of neurology, 2006, Volume: 253, Issue:6

    Topics: Adolescent; Adult; Aged; Analysis of Variance; Exercise; Exercise Test; Female; Forearm; Humans; Lac

2006
Comparison between voluntary and stimulated contractions of the quadriceps femoris for growth hormone response and muscle damage.
    Journal of applied physiology (Bethesda, Md. : 1985), 2008, Volume: 104, Issue:1

    Topics: Adult; Creatine Kinase, MM Form; Electric Stimulation; Exercise; Human Growth Hormone; Humans; Isome

2008
Use of dynamic tests of muscle function and histomorphometry of quadriceps muscle biopsies in the investigation of patients with chronic alcohol misuse and chronic fatigue syndrome.
    Annals of clinical biochemistry, 1994, Volume: 31 ( Pt 5)

    Topics: Adult; Alcoholism; Ammonia; AMP Deaminase; Analysis of Variance; Biopsy, Needle; Creatine Kinase; Di

1994
Short-term aerobic training response in chronic myopathies.
    Muscle & nerve, 1999, Volume: 22, Issue:9

    Topics: Adolescent; Adult; Creatine Kinase; Exercise Test; Exercise Therapy; Female; Heart Rate; Humans; Lac

1999
Multicenter trial with ubidecarenone: treatment of 44 patients with mitochondrial myopathies.
    Revue neurologique, 1991, Volume: 147, Issue:6-7

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Coenzymes; DNA, Mitochondrial; Female; Humans; Lactates;

1991
Ubidecarenone in the treatment of mitochondrial myopathies: a multi-center double-blind trial.
    Journal of the neurological sciences, 1990, Volume: 100, Issue:1-2

    Topics: Blood Platelets; Chromosome Deletion; Coenzymes; DNA, Mitochondrial; Double-Blind Method; Female; Hu

1990

Other Studies

41 other studies available for lactic acid and Muscle Disorders

ArticleYear
Α rare case of myopathy, lactic acidosis, and severe rhabdomyolysis, due to a homozygous mutation of the ferredoxin-2 (FDX2) gene.
    American journal of medical genetics. Part A, 2023, Volume: 191, Issue:12

    Topics: Acidosis, Lactic; Cell Cycle Proteins; Child; Cytoskeletal Proteins; Female; Ferredoxins; Humans; La

2023
Absolute expressions of hypoxia-inducible factor-1 alpha (HIF1A) transcript and the associated genes in chicken skeletal muscle with white striping and wooden breast myopathies.
    PloS one, 2019, Volume: 14, Issue:8

    Topics: Animals; Chickens; Gene Expression Regulation; Glycogen; Hydrogen-Ion Concentration; Hypoxia; Hypoxi

2019
Effects of a Series of Acidic Drugs on L-Lactic Acid Transport by the Monocarboxylate Transporters MCT1 and MCT4.
    Current pharmaceutical biotechnology, 2017, Volume: 18, Issue:14

    Topics: Animals; Biological Transport; Cell Culture Techniques; Cell Line, Tumor; Drug-Related Side Effects

2017
The urinary organic acids profile in single large-scale mitochondrial DNA deletion disorders.
    Clinica chimica acta; international journal of clinical chemistry, 2018, Volume: 481

    Topics: 3-Hydroxybutyric Acid; Acyl-CoA Dehydrogenase, Long-Chain; Adolescent; Child; Child, Preschool; Cong

2018
Level of residual enzyme activity modulates the phenotype in phosphoglycerate kinase deficiency.
    Neurology, 2018, 09-11, Volume: 91, Issue:11

    Topics: Ergometry; Exercise Test; Exercise Tolerance; Genetic Diseases, X-Linked; Humans; Intellectual Disab

2018
Fat and carbohydrate metabolism during exercise in phosphoglucomutase type 1 deficiency.
    The Journal of clinical endocrinology and metabolism, 2013, Volume: 98, Issue:7

    Topics: Adult; Bicycling; Carbohydrate Metabolism; Exercise Test; Exercise Tolerance; Glucose; Glycogen Stor

2013
Mixed lactate and caffeine compound increases satellite cell activity and anabolic signals for muscle hypertrophy.
    Journal of applied physiology (Bethesda, Md. : 1985), 2015, Mar-15, Volume: 118, Issue:6

    Topics: Animals; Caffeine; Cell Differentiation; Cell Line; Cell Proliferation; Follistatin; Hypertrophy; La

2015
Elucidation of the mechanism of atorvastatin-induced myopathy in a rat model.
    Toxicology, 2016, 06-01, Volume: 359-360

    Topics: Adenosine Triphosphate; Animals; Atorvastatin; Creatine Kinase; Disease Models, Animal; Hydroxymethy

2016
Exercise responses in patients with chronically high creatine kinase levels.
    Muscle & nerve, 2017, Volume: 56, Issue:2

    Topics: Adult; Ammonia; Chronic Disease; Creatine Kinase; Exercise; Exercise Test; Female; Humans; Lactic Ac

2017
Hypoxia preconditioning by cobalt chloride enhances endurance performance and protects skeletal muscles from exercise-induced oxidative damage in rats.
    Acta physiologica (Oxford, England), 2010, Volume: 200, Issue:3

    Topics: Animals; Antioxidants; Cell Hypoxia; Cobalt; Creatine Kinase, MM Form; Cytoprotection; Disease Model

2010
MCT1, MCT4 and CD147 gene polymorphisms in healthy horses and horses with myopathy.
    Research in veterinary science, 2011, Volume: 91, Issue:3

    Topics: Amino Acid Sequence; Animals; Basigin; Biological Transport; Female; Gene Expression Regulation; Hor

2011
Blood metabolite data in response to maximal exercise in healthy subjects.
    Clinical physiology and functional imaging, 2012, Volume: 32, Issue:4

    Topics: Adult; Ammonia; Biomarkers; Energy Metabolism; Exercise; Exercise Test; Exercise Tolerance; Female;

2012
SLC22A5 mutations in a patient with systemic primary carnitine deficiency: the first Korean case confirmed by biochemical and molecular investigation.
    Annals of clinical and laboratory science, 2012,Fall, Volume: 42, Issue:4

    Topics: Ammonia; Base Sequence; Cardiomyopathies; Carnitine; Humans; Hyperammonemia; Infant, Newborn; Lactic

2012
[The lactate-ischemia test: efficient for diagnosis of myopathy?].
    Deutsche medizinische Wochenschrift (1946), 2002, Sep-20, Volume: 127, Issue:38

    Topics: Adult; Ammonia; Diagnosis, Differential; Female; Glycogen Storage Disease Type V; Humans; Ischemia;

2002
CHRONIC ACIDOSIS DUE TO AN ERROR IN LACTATE AND PYRUVATE METABOLISM. REPORT OF TWO CASES.
    Pediatrics, 1964, Volume: 34

    Topics: Acetoacetates; Acidosis; Blood; Blood Gas Analysis; Carbohydrate Metabolism; Carbohydrate Metabolism

1964
Enterovirus related metabolic myopathy: a postviral fatigue syndrome.
    Journal of neurology, neurosurgery, and psychiatry, 2003, Volume: 74, Issue:10

    Topics: Adult; DNA, Viral; Enterovirus; Enterovirus B, Human; Exercise; Exercise Test; Fatigue Syndrome, Chr

2003
Fuel utilization in patients with very long-chain acyl-coa dehydrogenase deficiency.
    Annals of neurology, 2004, Volume: 56, Issue:2

    Topics: Acyl-CoA Dehydrogenase, Long-Chain; Adult; Blood Glucose; Carbon Dioxide; Carbon Isotopes; Exercise;

2004
Fuel utilization in subjects with carnitine palmitoyltransferase 2 gene mutations.
    Annals of neurology, 2005, Volume: 57, Issue:1

    Topics: Adolescent; Adult; Alanine; Blood Glucose; Calorimetry; Carnitine O-Palmitoyltransferase; DNA Mutati

2005
Coenzyme Q10 deficiency and isolated myopathy.
    Neurology, 2006, Jan-24, Volume: 66, Issue:2

    Topics: Adult; Coenzymes; Creatine Kinase; Delivery, Obstetric; Disease Progression; Electron Transport Comp

2006
Proglycogen, macroglycogen, glucose, and glucose-6-phosphate concentrations in skeletal muscles of horses with polysaccharide storage myopathy performing light exercise.
    American journal of veterinary research, 2006, Volume: 67, Issue:9

    Topics: Animals; Biopsy; Creatine Kinase; Female; Glucose; Glucose-6-Phosphate; Glycogen; Glycogen Storage D

2006
A bioluminescence technique for quantitative and structure-associated imaging of pyruvate.
    Laboratory investigation; a journal of technical methods and pathology, 2007, Volume: 87, Issue:1

    Topics: Biological Assay; Biomarkers, Tumor; Chromatography, High Pressure Liquid; Diagnostic Imaging; Froze

2007
Acetazolamide prevents vacuolar myopathy in skeletal muscle of K(+) -depleted rats.
    British journal of pharmacology, 2008, Volume: 154, Issue:1

    Topics: Acetazolamide; Animals; Bendroflumethiazide; Carbonic Anhydrase Inhibitors; Cell Count; Dichlorphena

2008
Acquired multiple Acyl-CoA dehydrogenase deficiency in 10 horses with atypical myopathy.
    Neuromuscular disorders : NMD, 2008, Volume: 18, Issue:5

    Topics: Acyl-CoA Dehydrogenase; Acyl-CoA Dehydrogenases; Animals; Butyric Acid; Butyryl-CoA Dehydrogenase; C

2008
Human myoadenylate deaminase deficiency.
    Advances in experimental medicine and biology, 1984, Volume: 165 Pt A

    Topics: Amino Acid Metabolism, Inborn Errors; Ammonia; AMP Deaminase; Female; Humans; Lactates; Lactic Acid;

1984
Mitochondrial dysfunction in adult-onset myopathies with structural abnormalities.
    Acta neuropathologica, 1995, Volume: 89, Issue:2

    Topics: Adult; Age of Onset; Creatine Kinase; Electron Transport Complex IV; Female; Humans; Hydrogen-Ion Co

1995
Ergometer exercise in myoadenylate deaminase deficient patients.
    The Clinical investigator, 1993, Volume: 71, Issue:6

    Topics: Adult; Ammonia; AMP Deaminase; Citric Acid Cycle; DNA Mutational Analysis; Exercise Test; Humans; Hy

1993
Evaluation of PLGA microsphere size effect on myotoxicity using the isolated rodent skeletal muscle model.
    Pharmaceutical development and technology, 1996, Volume: 1, Issue:3

    Topics: Animals; Biocompatible Materials; Creatine Kinase; Lactic Acid; Male; Microspheres; Molecular Weight

1996
Lipid storage myopathy in a cocker spaniel.
    The Journal of small animal practice, 1999, Volume: 40, Issue:1

    Topics: Acetoacetates; Animals; Dog Diseases; Dogs; Lactic Acid; Lipid Metabolism, Inborn Errors; Male; Musc

1999
Exertional myalgia syndrome associated with diminished serum ammonia elevation in ischemic exercise testing.
    Military medicine, 1999, Volume: 164, Issue:9

    Topics: Adult; Ammonia; AMP Deaminase; Biopsy; Chronic Disease; Exercise Test; Humans; Lactic Acid; Male; Mu

1999
Metabolic abnormalities associated with skeletal myopathy in severe anorexia nervosa.
    Nutrition (Burbank, Los Angeles County, Calif.), 2000, Volume: 16, Issue:3

    Topics: Adolescent; Adult; Anemia; Anorexia Nervosa; Dipeptidases; Exercise; Female; Follicle Stimulating Ho

2000
Relationship between fat-to-fat-free mass ratio and decrements in leg strength after downhill running.
    Journal of applied physiology (Bethesda, Md. : 1985), 2001, Volume: 90, Issue:4

    Topics: Adenosine Triphosphate; Adult; Anaerobic Threshold; Body Composition; Creatine; Creatine Kinase; Gly

2001
[The lactate-ischemia test: expedient diagnosis of myopathy].
    Deutsche medizinische Wochenschrift (1946), 2002, Apr-12, Volume: 127, Issue:15

    Topics: Adult; Ammonia; Diagnosis, Differential; Female; Humans; Ischemia; Lactic Acid; Muscular Diseases

2002
Parenteral aluminum compounds produce a local toxic myopathy in rats: importance of the anion.
    Toxicologic pathology, 1992, Volume: 20, Issue:3 Pt 1

    Topics: Aluminum; Animals; Anions; Antacids; Citrates; Citric Acid; Diaphragm; Female; Infusions, Parenteral

1992
Effects of oral ribose on muscle metabolism during bicycle ergometer in patients with AMP-deaminase-deficiency.
    Advances in experimental medicine and biology, 1991, Volume: 309B

    Topics: Administration, Oral; Ammonia; AMP Deaminase; Exercise Test; Humans; Hypoxanthine; Hypoxanthines; In

1991
[Mitochondrial encephalomyopathy. Report of a case].
    Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry, 1990, Volume: 23, Issue:1

    Topics: Adult; Brain Diseases, Metabolic; Cerebral Infarction; Humans; Lactates; Lactic Acid; Male; Mitochon

1990
Mitochondrial myopathy with lactic acidaemia, Fanconi-De Toni-Debré syndrome and a disturbed succinate: cytochrome c oxidoreductase activity.
    European journal of pediatrics, 1988, Volume: 147, Issue:4

    Topics: Acidosis, Lactic; Carnitine; Fanconi Syndrome; Female; Humans; Infant, Newborn; Lactates; Lactic Aci

1988
[Neurological approach to mitochondrial abnormalities].
    No to hattatsu = Brain and development, 1987, Volume: 19, Issue:2

    Topics: Adolescent; Brain Diseases; Child; Child, Preschool; Cytochrome-c Oxidase Deficiency; Female; Humans

1987
Mitochondrial encephalomyopathy with sleep apnea.
    European neurology, 1988, Volume: 28, Issue:2

    Topics: Brain Diseases; Humans; Lactates; Lactic Acid; Male; Middle Aged; Mitochondria; Muscles; Muscular Di

1988
The clinical features of mitochondrial myopathy.
    Brain : a journal of neurology, 1986, Volume: 109 ( Pt 5)

    Topics: Adolescent; Adult; Aged; Central Nervous System Diseases; Creatine Kinase; Eye Diseases; Female; Hum

1986
Metabolic and ventilatory responses to exercise in patients with a deficient O2 utilization by a mitochondrial myopathy.
    Advances in experimental medicine and biology, 1985, Volume: 191

    Topics: Adolescent; Child; Female; Heart Rate; Humans; Lactates; Lactic Acid; Male; Mitochondria, Muscle; Mu

1985
[Lactic acid acidosis with mitochondrial myopathy due to a pyruvate dehydrogenase deficiency].
    Padiatrie und Padologie, 1985, Volume: 20, Issue:1

    Topics: Acidosis; Child; Humans; Lactates; Lactic Acid; Male; Mitochondria, Muscle; Muscular Diseases; Pyruv

1985