lactic acid has been researched along with Muscle Disorders in 55 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report on a patient, now 17 year old, in whom lactic acidosis was detected at the age of 7 while attempting to diagnose the causes of increasing weakness." | 7.67 | [Lactic acid acidosis with mitochondrial myopathy due to a pyruvate dehydrogenase deficiency]. ( Dworschak, E; Hammerer, I; Höpfel, I; Maurer, H; Sperl, W, 1985) |
| "Three unrelated, sporadic patients with muscle coenzyme Q10 (CoQ10) deficiency presented at 32, 29, and 6 years of age with proximal muscle weakness and elevated serum creatine kinase (CK) and lactate levels, but without myoglobinuria, ataxia, or seizures." | 3.73 | Coenzyme Q10 deficiency and isolated myopathy. ( DiMauro, S; Gempel, K; Horvath, R; Lochmüller, H; Müller-Höcker, J; Naini, A; Neuen-Jacob, E; Plöger, H; Pongratz, DE; Schneiderat, P; Schoser, BG, 2006) |
| "Aluminum lactate, injected in rats, produced skeletal muscle necrosis of diaphragm and abdominal wall subjacent to peritoneal surfaces." | 3.68 | Parenteral aluminum compounds produce a local toxic myopathy in rats: importance of the anion. ( Drakontides, AB; Levine, S; Saltzman, A, 1992) |
| "We report on a patient, now 17 year old, in whom lactic acidosis was detected at the age of 7 while attempting to diagnose the causes of increasing weakness." | 3.67 | [Lactic acid acidosis with mitochondrial myopathy due to a pyruvate dehydrogenase deficiency]. ( Dworschak, E; Hammerer, I; Höpfel, I; Maurer, H; Sperl, W, 1985) |
| " At the dosage of CoQ10 used in the study (2 mg/kg/day) the therapy requires long administration time before a response is demonstrable." | 2.67 | Multicenter trial with ubidecarenone: treatment of 44 patients with mitochondrial myopathies. ( Angelini, C; Bresolin, N; Carenzi, A; Castelli, E; Comi, G; Doriguzzi, C; Moroni, I; Scarlato, G, 1991) |
| "Atorvastatin treatment resulted in a rise in both CK (2X) and myoglobin (6X) level with graded degrees of muscle necrosis." | 1.43 | Elucidation of the mechanism of atorvastatin-induced myopathy in a rat model. ( Abdallah, D; El-Ganainy, SO; El-Khatib, AS; El-Mallah, A; Khattab, MM; Mohy El-Din, MM, 2016) |
| "Three patients with chronic progressive external ophthalmoplegia of adult-onset, generalized muscle atrophy and myalgia are described." | 1.29 | Mitochondrial dysfunction in adult-onset myopathies with structural abnormalities. ( Gold, R; Klopstock, T; Naumann, M; Paulus, W; Reichmann, H; Reiners, K; Schindler, R, 1995) |
| "The CT scan showed multiple intracerebral infarcts, basal ganglia calcifications, and cerebral atrophy." | 1.28 | [Mitochondrial encephalomyopathy. Report of a case]. ( Chen, Q, 1990) |
| "The carnitine concentration was diminished in blood and muscle tissue." | 1.27 | Mitochondrial myopathy with lactic acidaemia, Fanconi-De Toni-Debré syndrome and a disturbed succinate: cytochrome c oxidoreductase activity. ( Guggenbichler, JP; Ruitenbeek, W; Sengers, RC; Sperl, W; Stadhouders, AM; Trijbels, JM, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (14.55) | 18.7374 |
| 1990's | 13 (23.64) | 18.2507 |
| 2000's | 16 (29.09) | 29.6817 |
| 2010's | 17 (30.91) | 24.3611 |
| 2020's | 1 (1.82) | 2.80 |
| Authors | Studies |
|---|---|
| Gkiourtzis, N | 1 |
| Tramma, D | 1 |
| Papadopoulou-Legbelou, K | 1 |
| Moutafi, M | 1 |
| Evangeliou, A | 1 |
| Malila, Y | 1 |
| Thanatsang, K | 1 |
| Arayamethakorn, S | 1 |
| Uengwetwanit, T | 1 |
| Srimarut, Y | 1 |
| Petracci, M | 1 |
| Strasburg, GM | 1 |
| Rungrassamee, W | 1 |
| Visessanguan, W | 1 |
| Riley, MS | 1 |
| Nicholls, DP | 1 |
| Cooper, CB | 2 |
| Leung, YH | 1 |
| Belanger, F | 1 |
| Lu, J | 1 |
| Turgeon, J | 1 |
| Michaud, V | 1 |
| Semeraro, M | 1 |
| Boenzi, S | 1 |
| Carrozzo, R | 1 |
| Diodato, D | 1 |
| Martinelli, D | 1 |
| Olivieri, G | 1 |
| Antonetti, G | 1 |
| Sacchetti, E | 1 |
| Catesini, G | 1 |
| Rizzo, C | 1 |
| Dionisi-Vici, C | 1 |
| Vissing, J | 4 |
| Akman, HO | 1 |
| Aasly, J | 1 |
| Kahler, SG | 1 |
| Bacino, CA | 1 |
| DiMauro, S | 2 |
| Haller, RG | 1 |
| Preisler, N | 1 |
| Laforêt, P | 1 |
| Echaniz-Laguna, A | 1 |
| Ørngreen, MC | 3 |
| Lonsdorfer-Wolf, E | 1 |
| Doutreleau, S | 1 |
| Geny, B | 1 |
| Stojkovic, T | 1 |
| Piraud, M | 1 |
| Petit, FM | 1 |
| Oishi, Y | 1 |
| Tsukamoto, H | 1 |
| Yokokawa, T | 1 |
| Hirotsu, K | 1 |
| Shimazu, M | 1 |
| Uchida, K | 1 |
| Tomi, H | 1 |
| Higashida, K | 1 |
| Iwanaka, N | 1 |
| Hashimoto, T | 1 |
| El-Ganainy, SO | 1 |
| El-Mallah, A | 1 |
| Abdallah, D | 1 |
| Khattab, MM | 1 |
| Mohy El-Din, MM | 1 |
| El-Khatib, AS | 1 |
| Castagnaro, S | 1 |
| Pellegrini, C | 1 |
| Pellegrini, M | 1 |
| Chrisam, M | 1 |
| Sabatelli, P | 1 |
| Toni, S | 1 |
| Grumati, P | 1 |
| Ripamonti, C | 1 |
| Pratelli, L | 1 |
| Maraldi, NM | 1 |
| Cocchi, D | 1 |
| Righi, V | 1 |
| Faldini, C | 1 |
| Sandri, M | 1 |
| Bonaldo, P | 1 |
| Merlini, L | 1 |
| Dolezal, BA | 1 |
| Neufeld, EV | 1 |
| Shieh, P | 1 |
| Jenner, JR | 1 |
| Riley, M | 1 |
| Saxena, S | 2 |
| Shukla, D | 1 |
| Khan, YA | 1 |
| Singh, M | 1 |
| Bansal, A | 1 |
| Sairam, M | 1 |
| Jain, SK | 1 |
| Flodgren, GM | 1 |
| Crenshaw, AG | 1 |
| Hellström, F | 1 |
| Fahlström, M | 1 |
| Mykkänen, AK | 1 |
| Koho, NM | 1 |
| Reeben, M | 1 |
| McGowan, CM | 1 |
| Pösö, AR | 1 |
| Carrasco, L | 1 |
| Sañudo, B | 1 |
| de Hoyo, M | 1 |
| Pradas, F | 1 |
| Da Silva, ME | 1 |
| Mouadil, A | 1 |
| Debout, C | 1 |
| Read, MH | 1 |
| Morello, R | 1 |
| Allouche, S | 1 |
| Chapon, F | 1 |
| Yoon, YA | 1 |
| Lee, DH | 1 |
| Ki, CS | 1 |
| Lee, SY | 1 |
| Kim, JW | 1 |
| Lee, YW | 1 |
| Park, HD | 1 |
| Ernberg, M | 1 |
| Castrillon, EE | 1 |
| Ghafouri, B | 1 |
| Larsson, B | 1 |
| Gerdle, B | 1 |
| List, T | 1 |
| Svensson, P | 1 |
| Lindner, A | 1 |
| ISRAELS, S | 1 |
| HAWORTH, JC | 1 |
| GOURLEY, B | 1 |
| FORD, JD | 1 |
| Lane, RJ | 1 |
| Soteriou, BA | 1 |
| Zhang, H | 1 |
| Archard, LC | 1 |
| Nørgaard, MG | 1 |
| Sacchetti, M | 2 |
| van Engelen, BG | 1 |
| Dunø, M | 1 |
| Ejstrup, R | 1 |
| Christensen, E | 1 |
| Schwartz, M | 1 |
| Horvath, R | 1 |
| Schneiderat, P | 1 |
| Schoser, BG | 1 |
| Gempel, K | 1 |
| Neuen-Jacob, E | 1 |
| Plöger, H | 1 |
| Müller-Höcker, J | 1 |
| Pongratz, DE | 1 |
| Naini, A | 1 |
| Lochmüller, H | 1 |
| Hanisch, F | 1 |
| Eger, K | 1 |
| Bork, S | 1 |
| Lehnich, H | 1 |
| Deschauer, M | 1 |
| Zierz, S | 1 |
| Bröjer, JT | 1 |
| Essén-Gustavsson, B | 1 |
| Annandale, EJ | 1 |
| Valberg, SJ | 1 |
| Sattler, UG | 1 |
| Walenta, S | 1 |
| Mueller-Klieser, W | 1 |
| Jubeau, M | 1 |
| Sartorio, A | 1 |
| Marinone, PG | 1 |
| Agosti, F | 1 |
| Van Hoecke, J | 1 |
| Nosaka, K | 1 |
| Maffiuletti, NA | 1 |
| Tricarico, D | 1 |
| Lovaglio, S | 1 |
| Mele, A | 1 |
| Rotondo, G | 1 |
| Mancinelli, E | 1 |
| Meola, G | 1 |
| Camerino, DC | 1 |
| Westermann, CM | 1 |
| Dorland, L | 1 |
| Votion, DM | 1 |
| de Sain-van der Velden, MG | 1 |
| Wijnberg, ID | 1 |
| Wanders, RJ | 1 |
| Spliet, WG | 1 |
| Testerink, N | 1 |
| Berger, R | 1 |
| Ruiter, JP | 1 |
| van der Kolk, JH | 1 |
| Fishbein, WN | 1 |
| Naumann, M | 1 |
| Reiners, K | 1 |
| Gold, R | 1 |
| Schindler, R | 1 |
| Paulus, W | 1 |
| Klopstock, T | 1 |
| Reichmann, H | 1 |
| Wassif, WS | 2 |
| Sherman, D | 1 |
| Salisbury, JR | 1 |
| Peters, TJ | 2 |
| Gross, M | 2 |
| Gresser, U | 2 |
| Brazeau, GA | 1 |
| Sciame, M | 1 |
| al-Suwayeh, SA | 1 |
| Fattal, E | 1 |
| Platt, SR | 1 |
| Chrisman, CL | 1 |
| Shelton, GD | 1 |
| Taivassalo, T | 1 |
| De Stefano, N | 1 |
| Chen, J | 1 |
| Karpati, G | 1 |
| Arnold, DL | 1 |
| Argov, Z | 1 |
| Riggs, JE | 1 |
| Schochet, SS | 1 |
| Webb, RW | 1 |
| McLoughlin, DM | 1 |
| Morton, J | 1 |
| Spargo, E | 1 |
| Russell, GF | 1 |
| Belardinelli, R | 1 |
| Hickner, RC | 1 |
| Mehta, PM | 1 |
| Dyck, D | 1 |
| Devita, P | 1 |
| Houmard, JA | 1 |
| Koves, T | 1 |
| Byrd, P | 1 |
| Nonaka, I | 1 |
| Koch, HJ | 1 |
| Uyanik, G | 1 |
| Raschka, C | 1 |
| Levine, S | 1 |
| Saltzman, A | 1 |
| Drakontides, AB | 1 |
| Wagner, DR | 1 |
| Kamilli, I | 1 |
| Zöllner, N | 1 |
| Scarlato, G | 1 |
| Bresolin, N | 2 |
| Moroni, I | 2 |
| Doriguzzi, C | 2 |
| Castelli, E | 2 |
| Comi, G | 1 |
| Angelini, C | 2 |
| Carenzi, A | 1 |
| Ponzetto, C | 1 |
| Cossutta, E | 1 |
| Binda, A | 1 |
| Gallanti, A | 1 |
| Gabellini, S | 1 |
| de Barsy, T | 1 |
| Hers, HG | 1 |
| Chen, Q | 1 |
| Sperl, W | 2 |
| Ruitenbeek, W | 1 |
| Trijbels, JM | 1 |
| Sengers, RC | 1 |
| Stadhouders, AM | 1 |
| Guggenbichler, JP | 1 |
| Yokochi, K | 1 |
| Tatsumi, C | 1 |
| Takahashi, M | 1 |
| Yorifuji, S | 1 |
| Nishikawa, Y | 1 |
| Kitaguchi, M | 1 |
| Hashimoto, S | 1 |
| Tarui, S | 1 |
| Petty, RK | 1 |
| Harding, AE | 1 |
| Morgan-Hughes, JA | 1 |
| Bogaard, JM | 1 |
| Busch, HF | 1 |
| Arts, WF | 1 |
| Heijsteeg, M | 1 |
| Stam, H | 1 |
| Versprille, A | 1 |
| Maurer, H | 1 |
| Dworschak, E | 1 |
| Höpfel, I | 1 |
| Hammerer, I | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Blood Flow Restriction Training for The Shoulder: A Case for Proximal Benefit[NCT04540367] | 32 participants (Actual) | Interventional | 2017-11-10 | Completed | |||
| Low Protein Diet to Correct Defective Autophagy in Patients With Collagen VI Related Myopathies[NCT01438788] | Phase 2 | 8 participants (Actual) | Interventional | 2011-10-31 | Completed | ||
| Triheptanoin's Effect on Fatty Acid Oxidation and Exercise Tolerance in Patients With Debrancher Deficiency, Glycogenin-1 Deficiency and Phosphofructoinase Deficiency at Rest and During Exercise. A Randomized, Double-blind, Placebo-controlled, Cross-over [NCT03642860] | Phase 2 | 3 participants (Actual) | Interventional | 2018-08-15 | Terminated (stopped due to Problems with recruitment) | ||
| Fat and Sugar Metabolism During Exercise in Patients With Metabolic Myopathy[NCT02635269] | 60 participants (Actual) | Interventional | 2016-01-31 | Active, not recruiting | |||
| Phase 3 Trial of Coenzyme Q10 in Mitochondrial Disease[NCT00432744] | Phase 3 | 24 participants (Actual) | Interventional | 2007-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The McMaster Gross Motor Function is a validated scale ranging from 0 to 100 (the higher the better). Since there was the possibility of a subject becoming totally disabled our FDA peer reviewed design called for its use as follows: If the subject completed both periods, the score was calculated as the difference in scores between the end of Period 2 (at 12 months) minus that at the end of Period 1 (6 months). If a subject became totally disabled, this difference was considered as plus infinity if it occurred in period 1 (Penalizes period 1), and minus infinity if it occurred in Period 2 (Penalizes period 2). The two treatments were compared via the Wilcoxon test, and the effect size was estimated using Kendall's Tau-B. This is interpreted in a similar manner to correlation with positive values favoring COQenzyme10 and negative values favoring placebo. One of the links in this report is to the the GMFM scale and how it is scored. A link to the instrument is included. (NCT00432744)
Timeframe: Taken at 6 and 12 Months
| Intervention | units on a scale (Median) |
|---|---|
| Placebo First | -0.002 |
| CoenzymeQ10 Frist | -0.12 |
This is a multivariate analysis of the first two outcomes: Period 2 minus Period 1 GMFM88 and Peds Quality of Life, analyzed as follows: First, to be in the analysis, subjects must contribute at least one of these endpoints. Second, if the subject became totally disabled during period 1, the difference was defined as + infinity, (highest possible evidence favoring period 2), and if the subject became totally disabled in period 2, the subject was scored as - infinity (highest possible evidence favoring period 1). Period 2 minus period 1 differences were ranked form low to high with missing values scores at the mid-rank. The Hotelling T-square was computed on these ranks and the P-value was obtained from 100,000 rerandomizations as the fraction of rerandomizations with T-sq at least as large as that observed. (NCT00432744)
Timeframe: end of 12 month minus end of 6 month difference.
| Intervention | participants (Number) |
|---|---|
| Placebo First | 7 |
| CoenzymeQ10 Frist | 8 |
"The Pediatric Quality of Life Scale is a validated scale ranging from 0 to 100 (the higher the better). Since there was the possibility of a subject becoming totally disabled our FDA peer reviewed design called for its use as follows: If the subject completed both periods, the score was calculated as the difference in scores between the end of Period 2 (at 12 months) minus that at the end of Period 1 (6 months). If a subject became totally disabled, this difference was considered as plus infinity if it occurred in period 1 (Penalizes period 1), and minus infinity if it occurred in Period 2 (Penalizes period 2). The two treatments were compared via the Wilcoxon test, and the effect size was estimated using Kendall's Tau-B. This is interpreted in a similar manner to correlation with positive values favoring COQenzyme10 and negative values favoring placebo. Goggle pedsQL and Mapi to browse the copyrighted manual. A link to the instrument is included." (NCT00432744)
Timeframe: At 6 and 12 Months
| Intervention | units on a scale (Median) |
|---|---|
| Placebo First | -1.1 |
| CoenzymeQ10 Frist | -11.9 |
4 reviews available for lactic acid and Muscle Disorders
| Article | Year |
|---|---|
Cardiopulmonary Exercise Testing and Metabolic Myopathies.
Topics: Carbon Dioxide; Exercise Test; Exercise Tolerance; Humans; Lactic Acid; Muscular Diseases; Oxidative | 2017 |
[Physiopathology of exercise. Muscular adaptations].
Topics: Adaptation, Physiological; Anaerobic Threshold; Biopsy; Exercise; Exercise Test; Exercise Tolerance; | 2000 |
[Complex II (succinate-ubiquinone reductase) deficiency].
Topics: Electron Transport; Electron Transport Complex II; Genes, Recessive; Humans; Lactic Acid; Leigh Dise | 2001 |
Normal metabolism and disorders of carbohydrate metabolism.
Topics: Carbohydrate Metabolism; Enzymes; Glucose; Glycogen; Glycogen Storage Disease; Glycolysis; Humans; L | 1990 |
10 trials available for lactic acid and Muscle Disorders
| Article | Year |
|---|---|
Autophagy activation in COL6 myopathic patients by a low-protein-diet pilot trial.
Topics: Adult; Alanine; Autophagy; Biomarkers; Biopsy; Body Composition; Collagen Type VI; Contracture; Diet | 2016 |
Combining microdialysis and near-infrared spectroscopy for studying effects of low-load repetitive work on the intramuscular chemistry in trapezius myalgia.
Topics: Adiposity; Adult; Female; Glutamic Acid; Humans; Lactic Acid; Microdialysis; Muscle, Skeletal; Muscu | 2010 |
Effectiveness of low-frequency vibration recovery method on blood lactate removal, muscle contractile properties and on time to exhaustion during cycling at VO₂max power output.
Topics: Adult; Bicycling; Exercise Test; Humans; Lactic Acid; Male; Muscle Contraction; Muscle Strength; Mus | 2011 |
Experimental myalgia induced by repeated infusion of acidic saline into the human masseter muscle does not cause the release of algesic substances.
Topics: Acids; Adult; Female; Glucose; Glutamic Acid; Humans; Hyperalgesia; Lactic Acid; Male; Masseter Musc | 2013 |
Lactate production upon short-term non-ischemic forearm exercise in mitochondrial disorders and other myopathies.
Topics: Adolescent; Adult; Aged; Analysis of Variance; Exercise; Exercise Test; Female; Forearm; Humans; Lac | 2006 |
Comparison between voluntary and stimulated contractions of the quadriceps femoris for growth hormone response and muscle damage.
Topics: Adult; Creatine Kinase, MM Form; Electric Stimulation; Exercise; Human Growth Hormone; Humans; Isome | 2008 |
Use of dynamic tests of muscle function and histomorphometry of quadriceps muscle biopsies in the investigation of patients with chronic alcohol misuse and chronic fatigue syndrome.
Topics: Adult; Alcoholism; Ammonia; AMP Deaminase; Analysis of Variance; Biopsy, Needle; Creatine Kinase; Di | 1994 |
Short-term aerobic training response in chronic myopathies.
Topics: Adolescent; Adult; Creatine Kinase; Exercise Test; Exercise Therapy; Female; Heart Rate; Humans; Lac | 1999 |
Multicenter trial with ubidecarenone: treatment of 44 patients with mitochondrial myopathies.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Coenzymes; DNA, Mitochondrial; Female; Humans; Lactates; | 1991 |
Ubidecarenone in the treatment of mitochondrial myopathies: a multi-center double-blind trial.
Topics: Blood Platelets; Chromosome Deletion; Coenzymes; DNA, Mitochondrial; Double-Blind Method; Female; Hu | 1990 |
41 other studies available for lactic acid and Muscle Disorders
| Article | Year |
|---|---|
Α rare case of myopathy, lactic acidosis, and severe rhabdomyolysis, due to a homozygous mutation of the ferredoxin-2 (FDX2) gene.
Topics: Acidosis, Lactic; Cell Cycle Proteins; Child; Cytoskeletal Proteins; Female; Ferredoxins; Humans; La | 2023 |
Absolute expressions of hypoxia-inducible factor-1 alpha (HIF1A) transcript and the associated genes in chicken skeletal muscle with white striping and wooden breast myopathies.
Topics: Animals; Chickens; Gene Expression Regulation; Glycogen; Hydrogen-Ion Concentration; Hypoxia; Hypoxi | 2019 |
Effects of a Series of Acidic Drugs on L-Lactic Acid Transport by the Monocarboxylate Transporters MCT1 and MCT4.
Topics: Animals; Biological Transport; Cell Culture Techniques; Cell Line, Tumor; Drug-Related Side Effects | 2017 |
The urinary organic acids profile in single large-scale mitochondrial DNA deletion disorders.
Topics: 3-Hydroxybutyric Acid; Acyl-CoA Dehydrogenase, Long-Chain; Adolescent; Child; Child, Preschool; Cong | 2018 |
Level of residual enzyme activity modulates the phenotype in phosphoglycerate kinase deficiency.
Topics: Ergometry; Exercise Test; Exercise Tolerance; Genetic Diseases, X-Linked; Humans; Intellectual Disab | 2018 |
Fat and carbohydrate metabolism during exercise in phosphoglucomutase type 1 deficiency.
Topics: Adult; Bicycling; Carbohydrate Metabolism; Exercise Test; Exercise Tolerance; Glucose; Glycogen Stor | 2013 |
Mixed lactate and caffeine compound increases satellite cell activity and anabolic signals for muscle hypertrophy.
Topics: Animals; Caffeine; Cell Differentiation; Cell Line; Cell Proliferation; Follistatin; Hypertrophy; La | 2015 |
Elucidation of the mechanism of atorvastatin-induced myopathy in a rat model.
Topics: Adenosine Triphosphate; Animals; Atorvastatin; Creatine Kinase; Disease Models, Animal; Hydroxymethy | 2016 |
Exercise responses in patients with chronically high creatine kinase levels.
Topics: Adult; Ammonia; Chronic Disease; Creatine Kinase; Exercise; Exercise Test; Female; Humans; Lactic Ac | 2017 |
Hypoxia preconditioning by cobalt chloride enhances endurance performance and protects skeletal muscles from exercise-induced oxidative damage in rats.
Topics: Animals; Antioxidants; Cell Hypoxia; Cobalt; Creatine Kinase, MM Form; Cytoprotection; Disease Model | 2010 |
MCT1, MCT4 and CD147 gene polymorphisms in healthy horses and horses with myopathy.
Topics: Amino Acid Sequence; Animals; Basigin; Biological Transport; Female; Gene Expression Regulation; Hor | 2011 |
Blood metabolite data in response to maximal exercise in healthy subjects.
Topics: Adult; Ammonia; Biomarkers; Energy Metabolism; Exercise; Exercise Test; Exercise Tolerance; Female; | 2012 |
SLC22A5 mutations in a patient with systemic primary carnitine deficiency: the first Korean case confirmed by biochemical and molecular investigation.
Topics: Ammonia; Base Sequence; Cardiomyopathies; Carnitine; Humans; Hyperammonemia; Infant, Newborn; Lactic | 2012 |
[The lactate-ischemia test: efficient for diagnosis of myopathy?].
Topics: Adult; Ammonia; Diagnosis, Differential; Female; Glycogen Storage Disease Type V; Humans; Ischemia; | 2002 |
CHRONIC ACIDOSIS DUE TO AN ERROR IN LACTATE AND PYRUVATE METABOLISM. REPORT OF TWO CASES.
Topics: Acetoacetates; Acidosis; Blood; Blood Gas Analysis; Carbohydrate Metabolism; Carbohydrate Metabolism | 1964 |
Enterovirus related metabolic myopathy: a postviral fatigue syndrome.
Topics: Adult; DNA, Viral; Enterovirus; Enterovirus B, Human; Exercise; Exercise Test; Fatigue Syndrome, Chr | 2003 |
Fuel utilization in patients with very long-chain acyl-coa dehydrogenase deficiency.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Adult; Blood Glucose; Carbon Dioxide; Carbon Isotopes; Exercise; | 2004 |
Fuel utilization in subjects with carnitine palmitoyltransferase 2 gene mutations.
Topics: Adolescent; Adult; Alanine; Blood Glucose; Calorimetry; Carnitine O-Palmitoyltransferase; DNA Mutati | 2005 |
Coenzyme Q10 deficiency and isolated myopathy.
Topics: Adult; Coenzymes; Creatine Kinase; Delivery, Obstetric; Disease Progression; Electron Transport Comp | 2006 |
Proglycogen, macroglycogen, glucose, and glucose-6-phosphate concentrations in skeletal muscles of horses with polysaccharide storage myopathy performing light exercise.
Topics: Animals; Biopsy; Creatine Kinase; Female; Glucose; Glucose-6-Phosphate; Glycogen; Glycogen Storage D | 2006 |
A bioluminescence technique for quantitative and structure-associated imaging of pyruvate.
Topics: Biological Assay; Biomarkers, Tumor; Chromatography, High Pressure Liquid; Diagnostic Imaging; Froze | 2007 |
Acetazolamide prevents vacuolar myopathy in skeletal muscle of K(+) -depleted rats.
Topics: Acetazolamide; Animals; Bendroflumethiazide; Carbonic Anhydrase Inhibitors; Cell Count; Dichlorphena | 2008 |
Acquired multiple Acyl-CoA dehydrogenase deficiency in 10 horses with atypical myopathy.
Topics: Acyl-CoA Dehydrogenase; Acyl-CoA Dehydrogenases; Animals; Butyric Acid; Butyryl-CoA Dehydrogenase; C | 2008 |
Human myoadenylate deaminase deficiency.
Topics: Amino Acid Metabolism, Inborn Errors; Ammonia; AMP Deaminase; Female; Humans; Lactates; Lactic Acid; | 1984 |
Mitochondrial dysfunction in adult-onset myopathies with structural abnormalities.
Topics: Adult; Age of Onset; Creatine Kinase; Electron Transport Complex IV; Female; Humans; Hydrogen-Ion Co | 1995 |
Ergometer exercise in myoadenylate deaminase deficient patients.
Topics: Adult; Ammonia; AMP Deaminase; Citric Acid Cycle; DNA Mutational Analysis; Exercise Test; Humans; Hy | 1993 |
Evaluation of PLGA microsphere size effect on myotoxicity using the isolated rodent skeletal muscle model.
Topics: Animals; Biocompatible Materials; Creatine Kinase; Lactic Acid; Male; Microspheres; Molecular Weight | 1996 |
Lipid storage myopathy in a cocker spaniel.
Topics: Acetoacetates; Animals; Dog Diseases; Dogs; Lactic Acid; Lipid Metabolism, Inborn Errors; Male; Musc | 1999 |
Exertional myalgia syndrome associated with diminished serum ammonia elevation in ischemic exercise testing.
Topics: Adult; Ammonia; AMP Deaminase; Biopsy; Chronic Disease; Exercise Test; Humans; Lactic Acid; Male; Mu | 1999 |
Metabolic abnormalities associated with skeletal myopathy in severe anorexia nervosa.
Topics: Adolescent; Adult; Anemia; Anorexia Nervosa; Dipeptidases; Exercise; Female; Follicle Stimulating Ho | 2000 |
Relationship between fat-to-fat-free mass ratio and decrements in leg strength after downhill running.
Topics: Adenosine Triphosphate; Adult; Anaerobic Threshold; Body Composition; Creatine; Creatine Kinase; Gly | 2001 |
[The lactate-ischemia test: expedient diagnosis of myopathy].
Topics: Adult; Ammonia; Diagnosis, Differential; Female; Humans; Ischemia; Lactic Acid; Muscular Diseases | 2002 |
Parenteral aluminum compounds produce a local toxic myopathy in rats: importance of the anion.
Topics: Aluminum; Animals; Anions; Antacids; Citrates; Citric Acid; Diaphragm; Female; Infusions, Parenteral | 1992 |
Effects of oral ribose on muscle metabolism during bicycle ergometer in patients with AMP-deaminase-deficiency.
Topics: Administration, Oral; Ammonia; AMP Deaminase; Exercise Test; Humans; Hypoxanthine; Hypoxanthines; In | 1991 |
[Mitochondrial encephalomyopathy. Report of a case].
Topics: Adult; Brain Diseases, Metabolic; Cerebral Infarction; Humans; Lactates; Lactic Acid; Male; Mitochon | 1990 |
Mitochondrial myopathy with lactic acidaemia, Fanconi-De Toni-Debré syndrome and a disturbed succinate: cytochrome c oxidoreductase activity.
Topics: Acidosis, Lactic; Carnitine; Fanconi Syndrome; Female; Humans; Infant, Newborn; Lactates; Lactic Aci | 1988 |
[Neurological approach to mitochondrial abnormalities].
Topics: Adolescent; Brain Diseases; Child; Child, Preschool; Cytochrome-c Oxidase Deficiency; Female; Humans | 1987 |
Mitochondrial encephalomyopathy with sleep apnea.
Topics: Brain Diseases; Humans; Lactates; Lactic Acid; Male; Middle Aged; Mitochondria; Muscles; Muscular Di | 1988 |
The clinical features of mitochondrial myopathy.
Topics: Adolescent; Adult; Aged; Central Nervous System Diseases; Creatine Kinase; Eye Diseases; Female; Hum | 1986 |
Metabolic and ventilatory responses to exercise in patients with a deficient O2 utilization by a mitochondrial myopathy.
Topics: Adolescent; Child; Female; Heart Rate; Humans; Lactates; Lactic Acid; Male; Mitochondria, Muscle; Mu | 1985 |
[Lactic acid acidosis with mitochondrial myopathy due to a pyruvate dehydrogenase deficiency].
Topics: Acidosis; Child; Humans; Lactates; Lactic Acid; Male; Mitochondria, Muscle; Muscular Diseases; Pyruv | 1985 |