lactic acid has been researched along with Multiple Sclerosis in 41 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Multiple Sclerosis: An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a double-blind placebo-controlled crossover study of ten patients with multiple sclerosis, we found amantadine hydrochloride therapy to be effective in improving fatigability in six." | 9.06 | Amantadine, fatigue, and multiple sclerosis. ( Appenzeller, O; Rosenberg, GA, 1988) |
| "Melatonin has a beneficial role in adult rat models of multiple sclerosis (MS)." | 7.85 | Melatonin exacerbates acute experimental autoimmune encephalomyelitis by enhancing the serum levels of lactate: A potential biomarker of multiple sclerosis progression. ( Dokoohaki, S; Farhadi, N; Ghanbari, A; Ghareghani, M; Ghavamizadeh, M; Khodadoust, S; Parishani, M; Sadeghi, H; Zibara, K, 2017) |
| "In a double-blind placebo-controlled crossover study of ten patients with multiple sclerosis, we found amantadine hydrochloride therapy to be effective in improving fatigability in six." | 5.06 | Amantadine, fatigue, and multiple sclerosis. ( Appenzeller, O; Rosenberg, GA, 1988) |
| "Melatonin has a beneficial role in adult rat models of multiple sclerosis (MS)." | 3.85 | Melatonin exacerbates acute experimental autoimmune encephalomyelitis by enhancing the serum levels of lactate: A potential biomarker of multiple sclerosis progression. ( Dokoohaki, S; Farhadi, N; Ghanbari, A; Ghareghani, M; Ghavamizadeh, M; Khodadoust, S; Parishani, M; Sadeghi, H; Zibara, K, 2017) |
| "Persons with Multiple Sclerosis have elevated resting serum lactate concentrations compared to healthy controls (HC)." | 1.51 | Exercise-induced lactate responses in Multiple Sclerosis: A retrospective analysis. ( Eijnde, BO; Hansen, D; Keytsman, C; Wens, I, 2019) |
| "Multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) are inflammatory diseases of the central nervous system." | 1.46 | Metabolomic profiling of CSF in multiple sclerosis and neuromyelitis optica spectrum disorder by nuclear magnetic resonance. ( Hyun, JS; Jeong, IH; Kim, HH; Kim, HJ; Kong, BS; Park, SJ, 2017) |
| "Additionally, demyelination regions of some MS patients had increased lactic acid content, suggesting the presence of ischemic events." | 1.40 | Early pathological alterations of lower lumbar cords detected by ultrahigh-field MRI in a mouse multiple sclerosis model. ( Arima, Y; Kamimura, D; Komai, Y; Mori, Y; Murakami, M; Nakatsuji, Y; Terayama, Y; Yoshioka, Y; Zhu, D, 2014) |
| "Tumefactive demyelination (TD) is a relatively uncommon entity which mimics other focal intracranial lesions." | 1.37 | Conventional and advanced magnetic resonance imaging in tumefactive demyelination. ( Chatterjee, S; Kesavadas, C; Saini, J; Thomas, B, 2011) |
| "This report describes the use of exercise testing to guide clinical decision making for dosing of an aqua aerobic fitness intervention and illustrates positive effects of the intervention on cardiovascular fitness in 2 people with MS." | 1.33 | Outcomes of an aquatic exercise program including aerobic capacity, lactate threshold, and fatigue in two individuals with multiple sclerosis. ( Madras, D; Pariser, G; Weiss, E, 2006) |
| "Most of the brain tumors were characterized by strongly reduced total N-acetylaspartyl compounds and marked increases of myo-inositol and choline-containing compounds, consistent with a lack of neuroaxonal tissue and a proliferation of glial cells." | 1.31 | Quantitative proton magnetic resonance spectroscopy of focal brain lesions. ( Dechent, P; Frahm, J; Hanefeld, F; Herms, J; Markakis, E; Maxton, C; Wilken, B, 2000) |
| "In multiple sclerosis, myelopathy, stroke, epilepsy and viral meningitis glutamate, hypoxanthine, xanthine, and uric acid are increased 2-3-fold compared to controls." | 1.30 | Cerebrospinal fluid hypoxanthine, xanthine and uric acid levels may reflect glutamate-mediated excitotoxicity in different neurological diseases. ( Kempski, OS; Lowitzsch, K; Stover, JF, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (12.20) | 18.7374 |
| 1990's | 3 (7.32) | 18.2507 |
| 2000's | 12 (29.27) | 29.6817 |
| 2010's | 17 (41.46) | 24.3611 |
| 2020's | 4 (9.76) | 2.80 |
| Authors | Studies |
|---|---|
| Trostel, C | 1 |
| Laichinger, K | 1 |
| Hauser, TK | 1 |
| Saur, S | 1 |
| Krumbholz, M | 1 |
| Henes, J | 1 |
| Ziemann, U | 1 |
| Kowarik, MC | 1 |
| Amato, A | 1 |
| Ragonese, P | 1 |
| Ingoglia, S | 1 |
| Schiera, G | 1 |
| Schirò, G | 1 |
| Di Liegro, CM | 1 |
| Salemi, G | 1 |
| Di Liegro, I | 1 |
| Proia, P | 1 |
| Ghareghani, M | 3 |
| Farhadi, Z | 1 |
| Rivest, S | 1 |
| Zibara, K | 2 |
| Keytsman, C | 2 |
| Hansen, D | 2 |
| Wens, I | 2 |
| Eijnde, BO | 2 |
| de Toledo, JHDS | 1 |
| Fraga-Silva, TFC | 1 |
| Borim, PA | 1 |
| de Oliveira, LRC | 1 |
| Oliveira, EDS | 1 |
| Périco, LL | 1 |
| Hiruma-Lima, CA | 1 |
| de Souza, AAL | 1 |
| de Oliveira, CAF | 1 |
| Padilha, PM | 1 |
| Pinatto-Botelho, MF | 1 |
| Dos Santos, AA | 1 |
| Sartori, A | 1 |
| Zorzella-Pezavento, SFG | 1 |
| Kim, HH | 1 |
| Jeong, IH | 1 |
| Hyun, JS | 1 |
| Kong, BS | 1 |
| Kim, HJ | 1 |
| Park, SJ | 1 |
| Guglielmetti, C | 1 |
| Najac, C | 1 |
| Didonna, A | 1 |
| Van der Linden, A | 1 |
| Ronen, SM | 1 |
| Chaumeil, MM | 1 |
| Cho, JJ | 1 |
| Stewart, JM | 1 |
| Drashansky, TT | 1 |
| Brusko, MA | 1 |
| Zuniga, AN | 1 |
| Lorentsen, KJ | 1 |
| Keselowsky, BG | 1 |
| Avram, D | 1 |
| Schlüter, K | 1 |
| Maier, J | 1 |
| Patra, S | 1 |
| Gold, SM | 3 |
| Heesen, C | 3 |
| Schulz, KH | 3 |
| Rosko, L | 1 |
| Smith, VN | 1 |
| Yamazaki, R | 1 |
| Huang, JK | 1 |
| Haarmann, A | 1 |
| Hähnel, L | 1 |
| Schuhmann, MK | 1 |
| Buttmann, M | 1 |
| Szafirska, M | 1 |
| Urbanik, A | 1 |
| Róg, T | 1 |
| Mori, Y | 1 |
| Murakami, M | 1 |
| Arima, Y | 1 |
| Zhu, D | 1 |
| Terayama, Y | 1 |
| Komai, Y | 1 |
| Nakatsuji, Y | 1 |
| Kamimura, D | 1 |
| Yoshioka, Y | 1 |
| Dendale, P | 1 |
| Hoveizi, E | 1 |
| Tavakol, S | 1 |
| Ebrahimi-Barough, S | 1 |
| Gammon, JM | 1 |
| Tostanoski, LH | 1 |
| Adapa, AR | 1 |
| Chiu, YC | 1 |
| Jewell, CM | 1 |
| Cleland, BT | 1 |
| Ingraham, BA | 1 |
| Pitluck, MC | 1 |
| Woo, D | 1 |
| Ng, AV | 1 |
| Albanese, M | 1 |
| Zagaglia, S | 1 |
| Landi, D | 1 |
| Boffa, L | 1 |
| Nicoletti, CG | 1 |
| Marciani, MG | 1 |
| Mandolesi, G | 1 |
| Marfia, GA | 1 |
| Buttari, F | 1 |
| Mori, F | 1 |
| Centonze, D | 1 |
| Dokoohaki, S | 2 |
| Ghanbari, A | 2 |
| Farhadi, N | 2 |
| Khodadoust, S | 1 |
| Parishani, M | 1 |
| Ghavamizadeh, M | 1 |
| Sadeghi, H | 2 |
| Hosseini, SM | 1 |
| Mohammadi, R | 1 |
| Fonalledas Perelló, MA | 1 |
| Politi, JV | 1 |
| Dallo Lizarraga, MA | 1 |
| Cardona, RS | 1 |
| Regenold, WT | 1 |
| Phatak, P | 1 |
| Makley, MJ | 1 |
| Stone, RD | 1 |
| Kling, MA | 1 |
| Saini, J | 1 |
| Chatterjee, S | 1 |
| Thomas, B | 1 |
| Kesavadas, C | 1 |
| Hartmann, S | 2 |
| Mladek, M | 2 |
| Lang, UE | 1 |
| Hellweg, R | 1 |
| Reer, R | 2 |
| Braumann, KM | 2 |
| Watanabe, H | 1 |
| Fukatsu, H | 1 |
| Ito, T | 1 |
| Iijima, M | 1 |
| Mabuchi, N | 1 |
| Sobue, G | 1 |
| LOWENTHAL, A | 1 |
| VAN SANDE, M | 1 |
| KARCHER, D | 1 |
| Wiedemann, K | 1 |
| Kendi, AT | 1 |
| Tan, FU | 1 |
| Kendi, M | 1 |
| Yilmaz, S | 1 |
| Huvaj, S | 1 |
| Tellioğlu, S | 1 |
| Kapeller, P | 1 |
| Ropele, S | 1 |
| Enzinger, C | 1 |
| Lahousen, T | 1 |
| Strasser-Fuchs, S | 1 |
| Schmidt, R | 1 |
| Fazekas, F | 1 |
| Pariser, G | 1 |
| Madras, D | 1 |
| Weiss, E | 1 |
| Cianfoni, A | 1 |
| Niku, S | 1 |
| Imbesi, SG | 1 |
| Hoberg, B | 1 |
| Delank, HW | 1 |
| Steen, G | 1 |
| Ransnäs, L | 1 |
| Landtblom, AM | 1 |
| Sjöqvist, L | 1 |
| Söderfeldt, B | 1 |
| Nyland, H | 1 |
| Thuomas, KA | 1 |
| Stover, JF | 1 |
| Lowitzsch, K | 1 |
| Kempski, OS | 1 |
| Wilken, B | 1 |
| Dechent, P | 1 |
| Herms, J | 1 |
| Maxton, C | 1 |
| Markakis, E | 1 |
| Hanefeld, F | 1 |
| Frahm, J | 1 |
| McLean, MA | 1 |
| Woermann, FG | 1 |
| Barker, GJ | 1 |
| Duncan, JS | 1 |
| Simone, IL | 1 |
| Tortorella, C | 1 |
| Federico, F | 1 |
| Liguori, M | 1 |
| Lucivero, V | 1 |
| Giannini, P | 1 |
| Carrara, D | 1 |
| Bellacosa, A | 1 |
| Livrea, P | 1 |
| Arnold, DL | 1 |
| Matthews, PM | 1 |
| Francis, GS | 1 |
| O'Connor, J | 1 |
| Antel, JP | 1 |
| Rosenberg, GA | 1 |
| Appenzeller, O | 1 |
| Young, PR | 1 |
| Snyder, WR | 1 |
| Vacante, DA | 1 |
| Waickus, CM | 1 |
| Zygas, AP | 1 |
| Grynspan, F | 1 |
| Karunatilake, C | 1 |
| Wilson, DH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluating the Potential Role of Melatonin in Subjects With Relapsing Multiple Sclerosis (MS)[NCT03498131] | Early Phase 1 | 30 participants (Actual) | Interventional | 2018-05-09 | Completed | ||
| Cardiovascular Fitness and the Influence of a Controlled Combined Exercise Program on Fatigue and Depression of Newly Diagnosed Patients With Multiple Sclerosis[NCT05671588] | 70 participants (Anticipated) | Interventional | 2022-05-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for lactic acid and Multiple Sclerosis
| Article | Year |
|---|---|
Oligodendrocyte Bioenergetics in Health and Disease.
Topics: Animals; Aspartic Acid; Axons; Brain; Energy Metabolism; Glucose; Humans; Lactic Acid; Mitochondria; | 2019 |
[Magnetic resonance spectroscopy and its clinical applications in multiple sclerosis].
Topics: Adult; Aspartic Acid; Brain; Choline; Creatine; Humans; Lactic Acid; Magnetic Resonance Spectroscopy | 2003 |
5 trials available for lactic acid and Multiple Sclerosis
| Article | Year |
|---|---|
Lactate Threshold Training Program on Patients with Multiple Sclerosis: A Multidisciplinary Approach.
Topics: Adult; Biomarkers; Brain-Derived Neurotrophic Factor; Dehydroepiandrosterone; Exercise; Exercise The | 2021 |
Is long-term exercise intervention effective to improve cardiac autonomic control during exercise in subjects with multiple sclerosis? A randomized controlled trial.
Topics: Analysis of Variance; Autonomic Nervous System; Chi-Square Distribution; Exercise Test; Exercise The | 2015 |
Endocrine and cytokine responses to standardized physical stress in multiple sclerosis.
Topics: Adrenocorticotropic Hormone; Adult; Analysis of Variance; beta-Endorphin; Cytokines; Epinephrine; Ex | 2003 |
Quantitative analysis of short echo time (1)H-MRSI of cerebral gray and white matter.
Topics: Adult; Aspartic Acid; Brain; Brain Chemistry; Calibration; Cerebrospinal Fluid; Choline; Creatine; D | 2000 |
Amantadine, fatigue, and multiple sclerosis.
Topics: Amantadine; beta-Endorphin; beta-Lipotropin; Disability Evaluation; Fatigue; Humans; Lactates; Lacti | 1988 |
34 other studies available for lactic acid and Multiple Sclerosis
| Article | Year |
|---|---|
Tumefactive demyelinating CNS lesion in a 60-year-old woman with familial Mediterranean fever.
Topics: Choline; Familial Mediterranean Fever; Female; Humans; Lactic Acid; Magnetic Resonance Imaging; Magn | 2022 |
PDK4 Inhibition Ameliorates Melatonin Therapy by Modulating Cerebral Metabolism and Remyelination in an EAE Demyelinating Mouse Model of Multiple Sclerosis.
Topics: Animals; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Lactic Acid; Melatonin | 2022 |
Exercise-induced lactate responses in Multiple Sclerosis: A retrospective analysis.
Topics: Adult; Exercise; Exercise Therapy; Female; Humans; Lactic Acid; Male; Multiple Sclerosis | 2019 |
Organic Selenium Reaches the Central Nervous System and Downmodulates Local Inflammation: A Complementary Therapy for Multiple Sclerosis?
Topics: Animals; Anti-Inflammatory Agents; Central Nervous System; Disease Models, Animal; Encephalomyelitis | 2020 |
Metabolomic profiling of CSF in multiple sclerosis and neuromyelitis optica spectrum disorder by nuclear magnetic resonance.
Topics: Acetates; Acetone; Adolescent; Adult; Aged; Child; Citric Acid; Female; Formates; Glucose; Humans; H | 2017 |
Hyperpolarized
Topics: Animals; Carbon Isotopes; Cuprizone; Disease Models, Animal; Female; Lactic Acid; Magnetic Resonance | 2017 |
An antigen-specific semi-therapeutic treatment with local delivery of tolerogenic factors through a dual-sized microparticle system blocks experimental autoimmune encephalomyelitis.
Topics: Animals; Antigens; CD4-Positive T-Lymphocytes; Delayed-Action Preparations; Dendritic Cells; Drug De | 2017 |
Aberrant peak lactate response in MS.
Topics: Exercise; Exercise Test; Female; Humans; Lactic Acid; Male; Multiple Sclerosis; Oxygen Consumption | 2017 |
Age-adjusted CSF β2-microglobulin and lactate are increased and ACE is decreased in patients with multiple sclerosis, but only lactate correlates with clinical disease duration and severity.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; beta 2-Microglobulin; Biomarkers; Cohort St | 2018 |
[The metabolic abnormalities in plaques of multiple sclerosis patients - the assessment in proton MR spectroscopy (1HMRS)].
Topics: Adult; Aspartic Acid; Axons; Brain; Choline; Creatine; Female; Humans; Lactic Acid; Leukoencephalopa | 2013 |
Early pathological alterations of lower lumbar cords detected by ultrahigh-field MRI in a mouse multiple sclerosis model.
Topics: Angiography; Animals; Blood Vessels; Blood-Brain Barrier; Cell Movement; Demyelinating Diseases; Dis | 2014 |
Neuroprotective Effect of Transplanted Neural Precursors Embedded on PLA/CS Scaffold in an Animal Model of Multiple Sclerosis.
Topics: Animals; Axons; Cell Differentiation; Cell- and Tissue-Based Therapy; Disease Models, Animal; Lactic | 2015 |
Controlled delivery of a metabolic modulator promotes regulatory T cells and restrains autoimmunity.
Topics: Animals; Antigen Presentation; Autoimmunity; Benzopyrans; Cell Proliferation; Coculture Techniques; | 2015 |
Reliability and Validity of Ratings of Perceived Exertion in Persons With Multiple Sclerosis.
Topics: Adult; Blood Pressure; Case-Control Studies; Disability Evaluation; Disabled Persons; Fatigue; Femal | 2016 |
Cerebrospinal fluid lactate is associated with multiple sclerosis disease progression.
Topics: Adult; Case-Control Studies; Disability Evaluation; Disease Progression; Female; Humans; Lactic Acid | 2016 |
Melatonin exacerbates acute experimental autoimmune encephalomyelitis by enhancing the serum levels of lactate: A potential biomarker of multiple sclerosis progression.
Topics: Animals; Biomarkers; Disease Progression; Encephalomyelitis, Autoimmune, Experimental; Female; Lacti | 2017 |
Methylprednisolone improves lactate metabolism through reduction of elevated serum lactate in rat model of multiple sclerosis.
Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experiment | 2016 |
The cerebrospinal fluid lactate is decreased in early stages of multiple sclerosis.
Topics: Adult; Aged; Disease Progression; Female; Humans; Lactic Acid; Male; Middle Aged; Multiple Sclerosis | 2008 |
Cerebrospinal fluid evidence of increased extra-mitochondrial glucose metabolism implicates mitochondrial dysfunction in multiple sclerosis disease progression.
Topics: Adult; Analysis of Variance; Disease Progression; Female; Fructose; Glucose; Humans; Lactic Acid; Ma | 2008 |
Conventional and advanced magnetic resonance imaging in tumefactive demyelination.
Topics: Adolescent; Adult; Aspartic Acid; Brain; Brain Mapping; Child; Choline; Contrast Media; Demyelinatin | 2011 |
Basal serum levels and reactivity of nerve growth factor and brain-derived neurotrophic factor to standardized acute exercise in multiple sclerosis and controls.
Topics: Adult; Age Factors; Analysis of Variance; Brain-Derived Neurotrophic Factor; Exercise Test; Female; | 2003 |
[Increase of the concentration of dehydrogenase of lactic acid and malic acid in the white substance in demyelinizing diseases].
Topics: Demyelinating Diseases; Humans; Lactic Acid; Malates; Multiple Sclerosis; Nervous System; Oxidoreduc | 1961 |
MR spectroscopy of cervical spinal cord in patients with multiple sclerosis.
Topics: Adult; Aspartic Acid; Case-Control Studies; Cervical Vertebrae; Choline; Creatine; Female; Humans; I | 2004 |
Discrimination of white matter lesions and multiple sclerosis plaques by short echo quantitative 1H-magnetic resonance spectroscopy.
Topics: Adult; Aged; Analysis of Variance; Aspartic Acid; Brain; Case-Control Studies; Creatine; Female; Fou | 2005 |
Outcomes of an aquatic exercise program including aerobic capacity, lactate threshold, and fatigue in two individuals with multiple sclerosis.
Topics: Adult; Exercise; Exercise Tolerance; Fatigue; Female; Humans; Lactic Acid; Middle Aged; Multiple Scl | 2006 |
Metabolite findings in tumefactive demyelinating lesions utilizing short echo time proton magnetic resonance spectroscopy.
Topics: Adolescent; Adult; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Demyelinating Diseases; | 2007 |
[Cerebrospinal fluid findings in brain atrophies detected by computer tomography].
Topics: Alcoholism; Atrophy; Brain; Brain Damage, Chronic; Brain Ischemia; Cerebrospinal Fluid Proteins; Enc | 1984 |
Organic acids or urine in multiple sclerosis.
Topics: Aconitic Acid; Adipates; Carboxylic Acids; Fatty Acids, Monounsaturated; Fatty Acids, Unsaturated; F | 1983 |
Proton MR spectroscopy and MR imaging in acute and chronic multiple sclerosis--ringlike appearances in acute plaques.
Topics: Adult; Aged; Aspartic Acid; Brain; Case-Control Studies; Choline; Creatine; Female; Humans; Inositol | 1996 |
Cerebrospinal fluid hypoxanthine, xanthine and uric acid levels may reflect glutamate-mediated excitotoxicity in different neurological diseases.
Topics: Adult; Albumins; Central Nervous System Diseases; Cerebrovascular Disorders; Chromatography, High Pr | 1997 |
Quantitative proton magnetic resonance spectroscopy of focal brain lesions.
Topics: Adolescent; Aspartic Acid; Biomarkers, Tumor; Brain; Brain Abscess; Brain Diseases; Brain Neoplasms; | 2000 |
Axonal damage in multiple sclerosis plaques: a combined magnetic resonance imaging and 1H-magnetic resonance spectroscopy study.
Topics: Adolescent; Adult; Aspartic Acid; Axons; Brain; Choline; Creatine; Female; Humans; Lactic Acid; Magn | 2001 |
Proton magnetic resonance spectroscopic imaging for metabolic characterization of demyelinating plaques.
Topics: Acute Disease; Adult; Aspartic Acid; Biopsy; Brain Chemistry; Brain Neoplasms; Choline; Creatine; De | 1992 |
The acid instability of myelin. A model for myelin degeneration in multiple sclerosis.
Topics: Animals; Cattle; Cells, Cultured; Hydrogen-Ion Concentration; Lactates; Lactic Acid; Macrophages; Mu | 1988 |