lactic acid has been researched along with Mouth Neoplasms in 29 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Mouth Neoplasms: Tumors or cancer of the MOUTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Oral squamous cell carcinoma (OSCC) is also enriched with microbiota, while the significance of microbiota in shaping the OSCC microenvironment remains elusive." | 1.91 | F. nucleatum facilitates oral squamous cell carcinoma progression via GLUT1-driven lactate production. ( Chen, G; Chen, L; Huang, X; Lei, H; Sun, J; Tang, Q; Wan, Q; Wo, K; Xie, M; Yin, Y; Yu, S; Zhang, J; Zheng, W, 2023) |
| "Oral squamous cell carcinoma (OSCC) is the most prevalent form of oral and maxillofacial malignancies, characterized by a low five-year survival rate primarily caused by invasion and metastasis." | 1.91 | Lactic acid-induced M2-like macrophages facilitate tumor cell migration and invasion via the GPNMB/CD44 axis in oral squamous cell carcinoma. ( Huang, W; Jiang, M; Li, B; Lin, Y; Qi, Y, 2023) |
| "The glucose metabolism of oral squamous cell carcinoma (HSC-2 and HSC-3) and normal epithelial (HaCaT) cells cultured under normoxic (21% oxygen) or hypoxic (1% oxygen) conditions was measured using a pH-stat system under normoxic or hypoxic conditions." | 1.62 | Hypoxically cultured cells of oral squamous cell carcinoma increased their glucose metabolic activity under normoxic conditions. ( Abiko, Y; Kobayashi, Y; Sasaki, K; Shinohara, Y; Takahashi, N; Washio, J, 2021) |
| "The migration and invasion of oral squamous cell carcinoma (OSCC) were promoted after being cocultured with the activated fibroblasts." | 1.51 | Tumoral microvesicle-activated glycometabolic reprogramming in fibroblasts promotes the progression of oral squamous cell carcinoma. ( Chen, Y; Huang, C; Jiang, E; Liu, K; Liu, Q; Shang, Z; Shao, Z; Wang, H; Wang, L; Wang, M; Xu, Z; Yan, T; Zhou, X, 2019) |
| "Oral squamous cell carcinoma (HSC-2, HSC-3) and normal (HaCaT) cells were used." | 1.46 | Real-time monitoring system for evaluating the acid-producing activity of oral squamous cell carcinoma cells at different environmental pH. ( Kitamura, J; Morishima, H; Shinohara, Y; Takahashi, N; Takahashi, T; Washio, J, 2017) |
| "Monitoring surgical removal of oral squamous cell carcinomas (OSCC) is being routinely performed through clinical and imaging follow-up." | 1.43 | Monitoring a 'metabolic shift' after surgical resection of oral squamous cell carcinomas by serum lactate dehydrogenase. ( Biegner, T; Calgéer, B; Grimm, M; Hoefert, S; Kraut, W; Krimmel, M; Munz, A; Reinert, S; Teriete, P, 2016) |
| "Oral squamous cell carcinoma (OSCC) is the sixth most common human malignancy." | 1.43 | Equating salivary lactate dehydrogenase (LDH) with LDH-5 expression in patients with oral squamous cell carcinoma: An insight into metabolic reprogramming of cancer cell as a predictor of aggressive phenotype. ( Dhupar, A; Saluja, TS; Spadigam, A; Syed, S, 2016) |
| "Treatment of recurring oral cancers is challenging as common surgical approaches are not feasible for these patients." | 1.42 | Drug coated microneedles for minimally-invasive treatment of oral carcinomas: development and in vitro evaluation. ( Boese, SE; Gill, HS; Luo, Z; Ma, Y; Nitin, N, 2015) |
| "Oral squamous cell carcinoma (OSCC) or cancers of oral cavity is one of the most common cancers worldwide with high rate of mortality and morbidity." | 1.42 | A cell-targeted chemotherapeutic nanomedicine strategy for oral squamous cell carcinoma therapy. ( Huo, ZJ; Li, XC; Liu, K; Liu, P; Pang, B; Wang, M; Wang, SJ; Wang, ZQ, 2015) |
| "The purpose of this study is to test if oral cancer cells can overcome the metabolic defects introduced by using small interfering RNA (siRNA) to knock down their expression of important metabolic enzymes." | 1.40 | Oral cancer cells may rewire alternative metabolic pathways to survive from siRNA silencing of metabolic enzymes. ( Brumbaugh, J; Chai, YD; Feng, S; Hu, S; Liu, X; Messadi, D; Misuno, K; Rabii, R; Zhang, M, 2014) |
| "The buccal cancer model was established in 64 golden hamsters, which were divided randomly into two groups for 32 animals in each group, CDDP-PLA-PEG-NP (6." | 1.33 | [Experimental study of cisplatin loaded polylactic acid-polyethylene glycol nano-particles for targeting oral carcinoma]. ( Chen, R; Chen, SW; Wan, YM; Yang, K, 2005) |
| "AIDS-related Kaposi's sarcoma (AIDS-KS), the most prevalent HIV-associated malignancy, is a debilitating, potentially fatal disease." | 1.31 | Sustained angiogenesis enables in vivo transplantation of mucocutaneous derived AIDS-related Kaposi's sarcoma cells in murine hosts. ( Kang, J; Mallery, SR; Ness, GM; Pei, P; Schwendeman, SP; Zhu, G, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.45) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (34.48) | 29.6817 |
| 2010's | 13 (44.83) | 24.3611 |
| 2020's | 5 (17.24) | 2.80 |
| Authors | Studies |
|---|---|
| Shinohara, Y | 2 |
| Washio, J | 2 |
| Kobayashi, Y | 1 |
| Abiko, Y | 1 |
| Sasaki, K | 1 |
| Takahashi, N | 2 |
| Nakashima, C | 1 |
| Fujiwara-Tani, R | 1 |
| Mori, S | 1 |
| Kishi, S | 1 |
| Ohmori, H | 1 |
| Fujii, K | 1 |
| Mori, T | 1 |
| Miyagawa, Y | 1 |
| Yamamoto, K | 1 |
| Kirita, T | 1 |
| Luo, Y | 1 |
| Kuniyasu, H | 1 |
| Hamilton, S | 3 |
| Shea, D | 3 |
| Ibsen, S | 3 |
| Brasino, M | 3 |
| Sun, J | 1 |
| Tang, Q | 1 |
| Yu, S | 1 |
| Xie, M | 1 |
| Zheng, W | 1 |
| Chen, G | 1 |
| Yin, Y | 1 |
| Huang, X | 1 |
| Wo, K | 1 |
| Lei, H | 1 |
| Zhang, J | 1 |
| Wan, Q | 1 |
| Chen, L | 1 |
| Lin, Y | 1 |
| Qi, Y | 1 |
| Jiang, M | 1 |
| Huang, W | 1 |
| Li, B | 1 |
| Morishima, H | 1 |
| Kitamura, J | 1 |
| Takahashi, T | 1 |
| Nieto, K | 1 |
| Pei, P | 2 |
| Wang, D | 1 |
| Mallery, SR | 2 |
| Schwendeman, SP | 2 |
| Wu, J | 1 |
| Hong, Y | 1 |
| Wu, T | 1 |
| Wang, J | 1 |
| Chen, X | 1 |
| Wang, Z | 1 |
| Cheng, B | 1 |
| Xia, J | 1 |
| Alanazi, SAS | 1 |
| Alduaiji, KTA | 1 |
| Shetty, B | 1 |
| Alrashedi, HA | 1 |
| Acharya, BLG | 1 |
| Vellappally, S | 1 |
| Divakar, DD | 1 |
| Gupta, P | 1 |
| Singh, M | 1 |
| Kumar, R | 1 |
| Belz, J | 1 |
| Shanker, R | 1 |
| Dwivedi, PD | 1 |
| Sridhar, S | 1 |
| Singh, SP | 1 |
| Jiang, E | 1 |
| Xu, Z | 1 |
| Wang, M | 2 |
| Yan, T | 1 |
| Huang, C | 1 |
| Zhou, X | 1 |
| Liu, Q | 1 |
| Wang, L | 1 |
| Chen, Y | 1 |
| Wang, H | 1 |
| Liu, K | 2 |
| Shao, Z | 1 |
| Shang, Z | 1 |
| Zhao, H | 1 |
| Hu, CY | 1 |
| Chen, WM | 1 |
| Huang, P | 1 |
| Zhang, M | 1 |
| Chai, YD | 1 |
| Brumbaugh, J | 1 |
| Liu, X | 1 |
| Rabii, R | 1 |
| Feng, S | 1 |
| Misuno, K | 1 |
| Messadi, D | 1 |
| Hu, S | 1 |
| Ma, Y | 1 |
| Boese, SE | 1 |
| Luo, Z | 1 |
| Nitin, N | 1 |
| Gill, HS | 1 |
| Grimm, M | 1 |
| Krimmel, M | 1 |
| Hoefert, S | 1 |
| Kraut, W | 1 |
| Calgéer, B | 1 |
| Biegner, T | 1 |
| Teriete, P | 1 |
| Munz, A | 1 |
| Reinert, S | 1 |
| Wang, ZQ | 1 |
| Huo, ZJ | 1 |
| Li, XC | 1 |
| Liu, P | 1 |
| Pang, B | 1 |
| Wang, SJ | 1 |
| Saluja, TS | 1 |
| Spadigam, A | 1 |
| Dhupar, A | 1 |
| Syed, S | 1 |
| Xu, Q | 1 |
| Zhang, Q | 1 |
| Ishida, Y | 1 |
| Hajjar, S | 1 |
| Tang, X | 1 |
| Shi, H | 1 |
| Dang, CV | 1 |
| Le, AD | 1 |
| Yang, K | 5 |
| Wen, Y | 4 |
| Li, L | 2 |
| Wang, C | 4 |
| Hou, S | 1 |
| Li, C | 1 |
| Wang, X | 1 |
| Chen, SW | 1 |
| Chen, R | 1 |
| Wan, YM | 1 |
| Jyränki, J | 1 |
| Suominen, S | 1 |
| Vuola, J | 1 |
| Bäck, L | 1 |
| Brix, M | 1 |
| Muret, P | 1 |
| Ricbourg, B | 1 |
| Humbert, P | 1 |
| Burke, GA | 1 |
| Bekiroglu, F | 1 |
| Brown, AM | 1 |
| Martin, TJ | 1 |
| Parmar, SC | 1 |
| Kang, J | 1 |
| Zhu, G | 1 |
| Ness, GM | 1 |
| Brizel, DM | 1 |
| Schroeder, T | 1 |
| Scher, RL | 1 |
| Walenta, S | 1 |
| Clough, RW | 1 |
| Dewhirst, MW | 1 |
| Mueller-Klieser, W | 1 |
| Wolf, C | 1 |
| Groh, V | 1 |
| Pehamberger, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Feasibility of Monitoring of Bone Free Flaps With Microdialysis Catheter Directly Positioned in Bone Tissue[NCT01879384] | 34 participants (Actual) | Interventional | 2011-02-28 | Completed | |||
| Trial of Dichloroacetate (DCA) in Glioblastoma Multiforme (GBM)[NCT05120284] | Phase 2 | 40 participants (Anticipated) | Interventional | 2022-07-01 | Recruiting | ||
| Concurrent Angiogenic and EGFR Blockade in Conjunction With Curative Intent Chemoradiation for Locally Advanced Head and Neck Cancer[NCT00140556] | Early Phase 1 | 28 participants (Actual) | Interventional | 2005-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Complete response (resolution) of tumor on clinical exam. (NCT00140556)
Timeframe: Within 30 days of completing RT
| Intervention | Participants (Number) |
|---|---|
| Entire Study Population | 25 |
1 trial available for lactic acid and Mouth Neoplasms
| Article | Year |
|---|---|
[Clinical application of anticancer nanoparticles targeting metastasis foci of cervical lymph nodes in patients with oral carcinoma].
Topics: Adult; Aged; Antineoplastic Agents, Phytogenic; Carcinoma, Squamous Cell; Chromatography, High Press | 2003 |
28 other studies available for lactic acid and Mouth Neoplasms
| Article | Year |
|---|---|
Hypoxically cultured cells of oral squamous cell carcinoma increased their glucose metabolic activity under normoxic conditions.
Topics: Adenosine Triphosphate; Cell Hypoxia; Cell Line, Tumor; Glucose; Humans; Lactic Acid; Mouth Neoplasm | 2021 |
An Axis between the Long Non-Coding RNA
Topics: Animals; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Flavin-Adenine Dinucleotide | 2022 |
On-chip dielectrophoretic recovery and detection of a lactate sensing probiotic from model human saliva.
Topics: Glycolysis; Humans; Lactic Acid; Mouth Neoplasms; Oxidative Phosphorylation; Saliva | 2023 |
On-chip dielectrophoretic recovery and detection of a lactate sensing probiotic from model human saliva.
Topics: Glycolysis; Humans; Lactic Acid; Mouth Neoplasms; Oxidative Phosphorylation; Saliva | 2023 |
On-chip dielectrophoretic recovery and detection of a lactate sensing probiotic from model human saliva.
Topics: Glycolysis; Humans; Lactic Acid; Mouth Neoplasms; Oxidative Phosphorylation; Saliva | 2023 |
On-chip dielectrophoretic recovery and detection of a lactate sensing probiotic from model human saliva.
Topics: Glycolysis; Humans; Lactic Acid; Mouth Neoplasms; Oxidative Phosphorylation; Saliva | 2023 |
On-chip dielectrophoretic recovery and detection of a lactate sensing probiotic from model human saliva.
Topics: Glycolysis; Humans; Lactic Acid; Mouth Neoplasms; Oxidative Phosphorylation; Saliva | 2023 |
On-chip dielectrophoretic recovery and detection of a lactate sensing probiotic from model human saliva.
Topics: Glycolysis; Humans; Lactic Acid; Mouth Neoplasms; Oxidative Phosphorylation; Saliva | 2023 |
On-chip dielectrophoretic recovery and detection of a lactate sensing probiotic from model human saliva.
Topics: Glycolysis; Humans; Lactic Acid; Mouth Neoplasms; Oxidative Phosphorylation; Saliva | 2023 |
On-chip dielectrophoretic recovery and detection of a lactate sensing probiotic from model human saliva.
Topics: Glycolysis; Humans; Lactic Acid; Mouth Neoplasms; Oxidative Phosphorylation; Saliva | 2023 |
On-chip dielectrophoretic recovery and detection of a lactate sensing probiotic from model human saliva.
Topics: Glycolysis; Humans; Lactic Acid; Mouth Neoplasms; Oxidative Phosphorylation; Saliva | 2023 |
F. nucleatum facilitates oral squamous cell carcinoma progression via GLUT1-driven lactate production.
Topics: Carcinoma, Squamous Cell; Glucose Transporter Type 1; GTPase-Activating Proteins; Head and Neck Neop | 2023 |
Lactic acid-induced M2-like macrophages facilitate tumor cell migration and invasion via the GPNMB/CD44 axis in oral squamous cell carcinoma.
Topics: Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Cell Proliferation; Head and Neck Neoplas | 2023 |
Real-time monitoring system for evaluating the acid-producing activity of oral squamous cell carcinoma cells at different environmental pH.
Topics: Acids; Ammonia; Antimetabolites; Carcinoma, Squamous Cell; Cell Line; Cell Line, Tumor; Deoxyglucose | 2017 |
In vivo controlled release of fenretinide from long-acting release depots for chemoprevention of oral squamous cell carcinoma recurrence.
Topics: Animals; Anticarcinogenic Agents; Carcinoma, Squamous Cell; Cell Line, Tumor; Chemoprevention; Delay | 2018 |
Stromal-epithelial lactate shuttle induced by tumor‑derived interleukin‑1β promotes cell proliferation in oral squamous cell carcinoma.
Topics: Actins; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Coculture Techniques; Fibrob | 2018 |
Pathogenic features of Streptococcus mutans isolated from dental prosthesis patients and diagnosed cancer patients with dental prosthesis.
Topics: Adult; Bacterial Adhesion; Cell Line, Tumor; Dental Prosthesis; Epithelial Cells; Female; Humans; La | 2018 |
Synthesis and in vitro studies of PLGA-DTX nanoconjugate as potential drug delivery vehicle for oral cancer.
Topics: Antineoplastic Agents; Cell Line, Tumor; Chemistry Techniques, Synthetic; Docetaxel; Drug Carriers; | 2018 |
Tumoral microvesicle-activated glycometabolic reprogramming in fibroblasts promotes the progression of oral squamous cell carcinoma.
Topics: Animals; Cancer-Associated Fibroblasts; Carcinoma, Squamous Cell; Caveolin 1; Cell Line, Tumor; Cocu | 2019 |
Lactate Promotes Cancer Stem-like Property of Oral Sequamous Cell Carcinoma.
Topics: AC133 Antigen; Aged; Axin Protein; Carcinoma, Squamous Cell; Cell Proliferation; Female; Gene Expres | 2019 |
Oral cancer cells may rewire alternative metabolic pathways to survive from siRNA silencing of metabolic enzymes.
Topics: Adenylate Kinase; Cell Line, Tumor; Cell Proliferation; Gene Knockdown Techniques; Glucose; Glutamin | 2014 |
Drug coated microneedles for minimally-invasive treatment of oral carcinomas: development and in vitro evaluation.
Topics: Administration, Oral; Animals; Antibiotics, Antineoplastic; Cadaver; Doxorubicin; Drug Delivery Syst | 2015 |
Monitoring a 'metabolic shift' after surgical resection of oral squamous cell carcinomas by serum lactate dehydrogenase.
Topics: Biomarkers, Tumor; Biopsy; Carcinoma, Squamous Cell; Female; Head and Neck Neoplasms; Humans; Immuno | 2016 |
A cell-targeted chemotherapeutic nanomedicine strategy for oral squamous cell carcinoma therapy.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; Cisplatin; Dr | 2015 |
Equating salivary lactate dehydrogenase (LDH) with LDH-5 expression in patients with oral squamous cell carcinoma: An insight into metabolic reprogramming of cancer cell as a predictor of aggressive phenotype.
Topics: Adult; Aged; Carcinoma, Squamous Cell; Epithelial Cells; Female; Humans; Isoenzymes; L-Lactate Dehyd | 2016 |
EGF induces epithelial-mesenchymal transition and cancer stem-like cell properties in human oral cancer cells via promoting Warburg effect.
Topics: Aldehyde Dehydrogenase 1 Family; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; CD24 Anti | 2017 |
[Preparation of cucurbitacinBE polylactic acid nano-particles for targeting cervical lymph nodes].
Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Delayed-Action Preparations; Drug Delivery Systems; | 2001 |
[Acute toxicity and local stimulate test of cucurbitacinBE polylactic acid nano-particles of targeting cervical lymph nodes].
Topics: Animals; Antineoplastic Agents; Drug Delivery Systems; Female; Injections; Lactic Acid; Lethal Dose | 2001 |
[The study of cucurbitacin BE polylactic acid nanoparticles delivering cucurbitacin BE to metastasized cervical lymph nodes in mice with oral cancer].
Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Squamous Cell; Cucurbitacins; Delayed-Action | 2003 |
[Experimental study of cisplatin loaded polylactic acid-polyethylene glycol nano-particles for targeting oral carcinoma].
Topics: Animals; Cisplatin; Drug Delivery Systems; Lactic Acid; Mice; Mouth Neoplasms; Nanoparticles; Neopla | 2005 |
Microdialysis in clinical practice: monitoring intraoral free flaps.
Topics: Adult; Blood Glucose; Female; Humans; Ischemia; Lactic Acid; Male; Microdialysis; Mouth Neoplasms; P | 2006 |
[Monitoring free flaps with cutaneous microdialysis: preliminary study in oral cavity reconstruction].
Topics: Blood Glucose; Feasibility Studies; Humans; Ischemia; Lactic Acid; Microdialysis; Microsurgery; Moni | 2006 |
Tracheostomy tape: more trouble than it's worth?
Topics: Aged; Female; Humans; Ischemia; Lactic Acid; Microdialysis; Mouth Neoplasms; Pyruvic Acid; Surgical | 2007 |
Sustained angiogenesis enables in vivo transplantation of mucocutaneous derived AIDS-related Kaposi's sarcoma cells in murine hosts.
Topics: Acquired Immunodeficiency Syndrome; Animals; Cattle; Delayed-Action Preparations; Disease Models, An | 2000 |
Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer.
Topics: Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Hypoxia; Follow-Up Studies; Head and Neck Neoplasm | 2001 |
Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer.
Topics: Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Hypoxia; Follow-Up Studies; Head and Neck Neoplasm | 2001 |
Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer.
Topics: Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Hypoxia; Follow-Up Studies; Head and Neck Neoplasm | 2001 |
Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer.
Topics: Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Hypoxia; Follow-Up Studies; Head and Neck Neoplasm | 2001 |
[Oral leukoedema--sequela of an artifact].
Topics: Adult; Diagnosis, Differential; Drug Combinations; Edema; Factitious Disorders; Female; Humans; Lact | 1986 |