lactic acid has been researched along with Meningitis, Pneumococcal in 23 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Meningitis, Pneumococcal: An acute purulent infection of the meninges and subarachnoid space caused by Streptococcus pneumoniae, most prevalent in children and adults over the age of 60. This illness may be associated with OTITIS MEDIA; MASTOIDITIS; SINUSITIS; RESPIRATORY TRACT INFECTIONS; sickle cell disease (ANEMIA, SICKLE CELL); skull fractures; and other disorders. Clinical manifestations include FEVER; HEADACHE; neck stiffness; and somnolence followed by SEIZURES; focal neurologic deficits (notably DEAFNESS); and COMA. (From Miller et al., Merritt's Textbook of Neurology, 9th ed, p111)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Lactic acidosis is an integral index of metabolic disturbances and severity of inflammation processes." | 7.74 | [Clinical implications of lactic acidosis in purulent meningitis]. ( Chentsov, VB; Menushenkova, SA; Migmanov, TE; Molotilova, TN; Nagibina, MV; Vengerov, IuIa, 2008) |
| "Our results gives support to the antiinflammatory effect of dexamethasone in experimental pneumococcal meningitis, and suggest that phenytoin may have also a protective effect on brain ischemia." | 7.69 | [Protective effect of dexamethasone and phenytoin in the treatment of experimental pneumococcal meningitis]. ( Cabellos, C; Gudiol, F; Martínez-Lacasa, J; Martos, A; Viladrich, PF, 1995) |
| "Analysis of cerebrospinal fluid lactic acid levels in 62 patients suspected of having meningitis was performed." | 7.66 | Diagnostic use of cerebrospinal fluid lactic acid levels in meningitis. ( Dwivedi, C; Reddy, CM, 1983) |
| "Lactic acidosis is an integral index of metabolic disturbances and severity of inflammation processes." | 3.74 | [Clinical implications of lactic acidosis in purulent meningitis]. ( Chentsov, VB; Menushenkova, SA; Migmanov, TE; Molotilova, TN; Nagibina, MV; Vengerov, IuIa, 2008) |
| "Our results gives support to the antiinflammatory effect of dexamethasone in experimental pneumococcal meningitis, and suggest that phenytoin may have also a protective effect on brain ischemia." | 3.69 | [Protective effect of dexamethasone and phenytoin in the treatment of experimental pneumococcal meningitis]. ( Cabellos, C; Gudiol, F; Martínez-Lacasa, J; Martos, A; Viladrich, PF, 1995) |
| " We suggest that activated leukocytes consume CSF glucose and produce lactic acid and secrete protons, which causes the CSF and interstitial acidosis." | 3.67 | Brain acidosis in experimental pneumococcal meningitis. ( Andersen, NE; Gyring, J; Hansen, AJ; Laursen, H; Siesjö, BK, 1989) |
| "Analysis of cerebrospinal fluid lactic acid levels in 62 patients suspected of having meningitis was performed." | 3.66 | Diagnostic use of cerebrospinal fluid lactic acid levels in meningitis. ( Dwivedi, C; Reddy, CM, 1983) |
| "The prognostic value of initial and sequential determinations of quantitative bacterial concentrations, leukocytes, glucose, lactate, lactic acid dehydrogenase, and creatine phosphokinase in CSF was examined in rabbits with experimental pneumococcal meningitis while they were receiving equivalent, rapidly bactericidal antibiotic therapy." | 3.66 | Cerebrospinal fluid prognostic indices in experimental pneumococcal meningitis. ( Boyd, J; Giampaolo, C; Sande, MA; Savory, J; Scheld, WM; Wills, MR, 1982) |
| "Neuronal injury in pneumococcal meningitis is a consequence of microglial activation and direct toxicity by bacterial products and systemic inflammation." | 1.38 | Intrathecal treatment with the anti-phosphorylcholine monoclonal antibody TEPC-15 decreases neuronal damage in experimental pneumococcal meningitis. ( Gerber, J; Nau, R; Redlich, S; Ribes, S; Schmidt, H; Tauber, SC, 2012) |
| "In animal models of Streptococcus pneumoniae meningitis, rifampin is neuroprotective in comparison to ceftriaxone." | 1.32 | Clindamycin is neuroprotective in experimental Streptococcus pneumoniae meningitis compared with ceftriaxone. ( Böttcher, T; Bunkowski, S; Christen, S; Gerber, J; Goiny, M; Kuhnt, U; Lotz, M; Lykkesfeldt, J; Nau, R; Ren, H; Schau, I; Spreer, A; Werner, C, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (43.48) | 18.7374 |
| 1990's | 7 (30.43) | 18.2507 |
| 2000's | 5 (21.74) | 29.6817 |
| 2010's | 1 (4.35) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vengerov, IuIa | 1 |
| Nagibina, MV | 1 |
| Chentsov, VB | 1 |
| Menushenkova, SA | 1 |
| Molotilova, TN | 1 |
| Migmanov, TE | 1 |
| Gerber, J | 4 |
| Redlich, S | 1 |
| Ribes, S | 2 |
| Tauber, SC | 1 |
| Schmidt, H | 3 |
| Nau, R | 7 |
| Cabellos, C | 4 |
| Fernàndez, A | 1 |
| Maiques, JM | 1 |
| Tubau, F | 2 |
| Ardanuy, C | 2 |
| Viladrich, PF | 2 |
| Liñares, J | 2 |
| Gudiol, F | 3 |
| Böttcher, T | 1 |
| Ren, H | 1 |
| Goiny, M | 1 |
| Lykkesfeldt, J | 1 |
| Kuhnt, U | 1 |
| Lotz, M | 1 |
| Bunkowski, S | 1 |
| Werner, C | 1 |
| Schau, I | 1 |
| Spreer, A | 1 |
| Christen, S | 1 |
| Taberner, F | 1 |
| Dwivedi, C | 1 |
| Reddy, CM | 1 |
| Vanprapar, N | 1 |
| Chavalittamrong, B | 1 |
| Limsathayurat, N | 1 |
| Ruf, B | 1 |
| Ernst, JD | 1 |
| Decazes, JM | 1 |
| Sande, MA | 4 |
| Brook, I | 1 |
| Scheld, WM | 1 |
| Giampaolo, C | 1 |
| Boyd, J | 1 |
| Savory, J | 1 |
| Wills, MR | 1 |
| Knight, JA | 1 |
| Dudek, SM | 1 |
| Haymond, RE | 1 |
| Martos, A | 1 |
| Martínez-Lacasa, J | 1 |
| Bhatt, SM | 1 |
| Lauretano, A | 1 |
| Halpin, C | 1 |
| Levine, RA | 1 |
| Xu, WZ | 1 |
| Nadol, JB | 1 |
| Tuomanen, E | 1 |
| Martynov, VA | 1 |
| Roslyĭ, IM | 1 |
| Kolobaeva, OV | 1 |
| Zysk, G | 2 |
| Fischer, FR | 1 |
| Stringaris, AK | 1 |
| Stuertz, K | 3 |
| Brück, W | 3 |
| Granert, C | 1 |
| Raud, J | 1 |
| Lindquist, L | 1 |
| Trostdorf, F | 2 |
| Reinert, RR | 1 |
| Nichterlein, T | 1 |
| Schmitz-Salue, M | 2 |
| Sadowski, I | 1 |
| Hopkins, SJ | 1 |
| van Rooijen, N | 1 |
| Huitinga, I | 1 |
| Wellmer, A | 1 |
| Prange, J | 1 |
| Lange, P | 1 |
| Michel, U | 1 |
| Eiffert, H | 1 |
| Andersen, NE | 1 |
| Gyring, J | 1 |
| Hansen, AJ | 1 |
| Laursen, H | 1 |
| Siesjö, BK | 1 |
| Täuber, MG | 2 |
| Borschberg, U | 1 |
| Khayam-Bashi, H | 1 |
23 other studies available for lactic acid and Meningitis, Pneumococcal
| Article | Year |
|---|---|
[Clinical implications of lactic acidosis in purulent meningitis].
Topics: Acidosis, Lactic; Adolescent; Adult; Aged; Female; Humans; Lactic Acid; Male; Meningitis, Meningococ | 2008 |
Intrathecal treatment with the anti-phosphorylcholine monoclonal antibody TEPC-15 decreases neuronal damage in experimental pneumococcal meningitis.
Topics: Animals; Anti-Bacterial Agents; Antibodies, Monoclonal; Ceftriaxone; Cells, Cultured; Dentate Gyrus; | 2012 |
Experimental study of LY333328 (oritavancin), alone and in combination, in therapy of cephalosporin-resistant pneumococcal meningitis.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Ceftriaxone; Cephalosporin | 2003 |
Clindamycin is neuroprotective in experimental Streptococcus pneumoniae meningitis compared with ceftriaxone.
Topics: Animals; Anti-Bacterial Agents; Body Temperature; Brain; Ceftriaxone; Cell Line, Tumor; Cerebrospina | 2004 |
Contribution of capsular and clonal types and beta-lactam resistance to the severity of experimental pneumococcal meningitis.
Topics: Adult; Animals; Bacteremia; Bacterial Capsules; beta-Lactam Resistance; Blood; Cerebrospinal Fluid; | 2008 |
Diagnostic use of cerebrospinal fluid lactic acid levels in meningitis.
Topics: Adolescent; Child; Child, Preschool; Humans; Infant; Infant, Newborn; Lactates; Lactic Acid; Meningi | 1983 |
Cerebrospinal fluid lactate level in childhood purulent meningitis.
Topics: Child, Preschool; Female; Humans; Infant; Lactates; Lactic Acid; Male; Meningitis; Meningitis, Haemo | 1983 |
[Lactate determination in the cerebrospinal fluid. Differential diagnostic significance].
Topics: Diagnosis, Differential; Escherichia coli Infections; Female; Humans; Klebsiella Infections; Lactate | 1981 |
Experimental pneumococcal meningitis: role of leukocytes in pathogenesis.
Topics: Animals; Cerebrospinal Fluid; Cerebrospinal Fluid Proteins; Glucose; Kinetics; Lactates; Lactic Acid | 1983 |
Stability of lactic acid in cerebrospinal fluid specimens.
Topics: Child; Child, Preschool; Female; Humans; Infant; Lactates; Lactic Acid; Male; Meningitis; Meningitis | 1982 |
Cerebrospinal fluid prognostic indices in experimental pneumococcal meningitis.
Topics: Animals; Creatine Kinase; Glucose; L-Lactate Dehydrogenase; Lactates; Lactic Acid; Leukocyte Count; | 1982 |
Early (chemical) diagnosis of bacterial meningitis--cerebrospinal fluid glucose, lactate, and lactate dehydrogenase compared.
Topics: Child; Clinical Enzyme Tests; Clinical Laboratory Techniques; Glucose; Humans; L-Lactate Dehydrogena | 1981 |
[Protective effect of dexamethasone and phenytoin in the treatment of experimental pneumococcal meningitis].
Topics: Animals; Brain Edema; Cerebrospinal Fluid Proteins; Dexamethasone; Lactates; Lactic Acid; Leukocyte | 1995 |
Progression of hearing loss in experimental pneumococcal meningitis: correlation with cerebrospinal fluid cytochemistry.
Topics: Animals; Cerebrospinal Fluid; Cerebrospinal Fluid Proteins; Cochlea; Disease Models, Animal; Ear, In | 1993 |
[The enzyme activity and pyruvate, lactate and 2,3-DPG levels in the erythrocytes of patients with severe forms of meningococcal infection and suppurative meningitis].
Topics: 2,3-Diphosphoglycerate; Adolescent; Adult; Aged; Diphosphoglyceric Acids; Erythrocytes; Female; Huma | 1996 |
Trovafloxacin delays the antibiotic-induced inflammatory response in experimental pneumococcal meningitis.
Topics: Adult; Animals; Anti-Infective Agents; Ceftriaxone; Cephalosporins; Disease Models, Animal; Fluoroqu | 1997 |
The polysaccharide fucoidin inhibits the antibiotic-induced inflammatory cascade in experimental pneumococcal meningitis.
Topics: Ampicillin; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cerebrospinal Fluid; Cerebrospinal Flu | 1998 |
Quinupristin/dalfopristin attenuates the inflammatory response and reduces the concentration of neuron-specific enolase in the cerebrospinal fluid of rabbits with experimental Streptococcus pneumoniae meningitis.
Topics: Animals; Anti-Bacterial Agents; Ceftriaxone; Cerebrospinal Fluid Proteins; Disease Models, Animal; I | 1999 |
Reduction of meningeal macrophages does not decrease migration of granulocytes into the CSF and brain parenchyma in experimental pneumococcal meningitis.
Topics: Analgesics, Non-Narcotic; Animals; Carboxylic Ester Hydrolases; Cell Count; Cell Movement; Cerebrosp | 1999 |
D- and L-lactate in rabbit and human bacterial meningitis.
Topics: Animals; Bacteria; Ceftriaxone; Humans; Lactic Acid; Meningitis, Bacterial; Meningitis, Pneumococcal | 2001 |
Brain acidosis in experimental pneumococcal meningitis.
Topics: Acidosis; Animals; Blood Glucose; Brain Diseases; Carbon Dioxide; Glucose; Humans; Hydrogen-Ion Conc | 1989 |
Influence of granulocytes on brain edema, intracranial pressure, and cerebrospinal fluid concentrations of lactate and protein in experimental meningitis.
Topics: Animals; Brain Edema; Cerebrospinal Fluid; Cerebrospinal Fluid Proteins; Granulocytes; Intracranial | 1988 |
Effects of ampicillin and corticosteroids on brain water content, cerebrospinal fluid pressure, and cerebrospinal fluid lactate levels in experimental pneumococcal meningitis.
Topics: Adrenal Cortex Hormones; Ampicillin; Animals; Body Water; Brain Chemistry; Brain Edema; Dexamethason | 1985 |