lactic acid has been researched along with Melanoma in 72 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| "A375 melanoma cancer cells were used for testing cellular entry and anticancer potentials of HMC and nano-7-hydroxy-6-methoxy coumarin (NHMC) through several standard protocols." | 7.76 | Polymeric nanoparticle encapsulation of a naturally occurring plant scopoletin and its effects on human melanoma cell A375. ( Bhattacharyya, SS; Boujedaini, N; Khuda-Bukhsh, AR; Paul, S, 2010) |
| " Measurement of pH in cerebrospinal fluid (CSF) yielded central lactic acidosis despite alkalosis in peripheral blood." | 7.74 | Central lactic acidosis, hyperventilation, and respiratory alkalosis: leading clinical features in a 3-year-old boy with malignant meningeal melanoma. ( Bierbach, U; Blüher, S; Hirsch, W; Kiess, W; Meixensberger, J; Schober, R; Schulz, M; Siekmeyer, W; Tröbs, RB, 2008) |
| "The melanoma cell metastasis to lungs was prevented by intravenous co-injection of B16BL6 melanoma cells with 1." | 5.33 | The effect of poly (aspartic acid-co-lactic acid) nanospheres on the lung metastasis of B16BL6 melanoma cells by intravenous administration. ( Hara, K; Huang, CC; Kawashima, Y; Mimura, H; Miwa, N; Tsujimoto, H, 2006) |
| " Here we show that LDHA-associated lactic acid accumulation in melanomas inhibits tumor surveillance by T and NK cells." | 3.83 | LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells. ( Berneburg, M; Blank, C; Bogdan, C; Brand, A; Bruss, C; Dettmer, K; Fichtner-Feigl, S; Geissler, EK; Haferkamp, S; Herr, W; Hoffmann, P; Karrer, S; Kastenberger, M; Kesselring, R; Klobuch, S; Koehl, GE; Kohl, E; Kolitzus, M; Kreutz, M; Mack, M; Mackensen, A; Matos, C; Mueller-Klieser, W; Oefner, PJ; Peter, K; Pouyssegur, J; Renner, K; Ritter, U; Schleicher, U; Schmid, M; Schoenhammer, G; Schreml, S; Seliger, B; Singer, K; Steven, A; Thiel, A; Ullrich, E; Villunger, A; Walenta, S, 2016) |
| "The bioactive polymer poly(L-glutamic acid)n-b-poly(D, L-lactic acid)m was synthesized and used to form doxorubicin-loaded hybrid polymeric micelles to treat melanoma." | 3.80 | Hybrid polymeric micelles based on bioactive polypeptides as pH-responsive delivery systems against melanoma. ( Fan, B; Gao, Z; Huang, W; Jin, M; Kang, L; Liu, S; Wang, QM, 2014) |
| "A375 melanoma cancer cells were used for testing cellular entry and anticancer potentials of HMC and nano-7-hydroxy-6-methoxy coumarin (NHMC) through several standard protocols." | 3.76 | Polymeric nanoparticle encapsulation of a naturally occurring plant scopoletin and its effects on human melanoma cell A375. ( Bhattacharyya, SS; Boujedaini, N; Khuda-Bukhsh, AR; Paul, S, 2010) |
| " Measurement of pH in cerebrospinal fluid (CSF) yielded central lactic acidosis despite alkalosis in peripheral blood." | 3.74 | Central lactic acidosis, hyperventilation, and respiratory alkalosis: leading clinical features in a 3-year-old boy with malignant meningeal melanoma. ( Bierbach, U; Blüher, S; Hirsch, W; Kiess, W; Meixensberger, J; Schober, R; Schulz, M; Siekmeyer, W; Tröbs, RB, 2008) |
| "The authors performed this study to evaluate the selective acidification of a human melanoma xenograft in mice with severe combined immunodeficiency with the induction of hyperglycemia (mean blood glucose level +/- standard error of the mean, 26 mmol/L +/- 1) and the intraperitoneal administration of metaiodobenzylguanidine (MIBG, 30 mg/kg), alpha-cyano-4-hydroxycinnamate (CNCn, 300 mg/kg), lonidamine (100 mg/kg), cariporide (HOE642, 160 mg/kg), or 4." | 3.71 | Enhancement of hyperglycemia-induced acidification of human melanoma xenografts with inhibitors of respiration and ion transport. ( Bansal, N; Glickson, JD; Leeper, DB; Pickup, S; Zhou, R, 2001) |
| " Thirty-three patients underwent ILP with rhTNF alpha and melphalan for melanoma or soft-tissue sarcoma." | 3.69 | [O2 utilization during hyperthermic extremity perfusion with rhTNF alpha and melphalan]. ( Beck, K; Haier, J; Hohenberger, P; Schlag, PM, 1997) |
| "Melanoma is a malignant tumor in which UVA (320-400 nm) radiation is considered to be an important risk factor." | 2.53 | UVA-Irradiation Induces Melanoma Invasion via the Enhanced Warburg Effect. ( Baban, TSA; Bauer, J; Berneburg, M; Garbe, C; Kamenisch, Y; Metzler, G; Rocken, M; Schittek, B; Schuller, W; Sinnberg, T; von Thaler, AK, 2016) |
| " Moreover, encapsulation protects the drug from deactivation by biological reactions and interactions with biomolecules, ensuring successful delivery and bioavailability for effective treatment." | 2.53 | PLGA-loaded nanomedicines in melanoma treatment: Future prospect for efficient drug delivery. ( Das, S; Khuda-Bukhsh, AR, 2016) |
| "Cutaneous melanoma is an aggressive and deadly cancer resulting from malignant transformation of cells involved in skin pigmentation." | 1.91 | Glycolysis regulator PFKP induces human melanoma cell proliferation and tumor growth. ( Chen, C; Zhang, X, 2023) |
| "Melanoma is the most lethal of all skin-related cancers with incidences continuously rising." | 1.62 | In Vitro Evaluation of CD276-CAR NK-92 Functionality, Migration and Invasion Potential in the Presence of Immune Inhibitory Factors of the Tumor Microenvironment. ( Baden, C; Chan, KC; Grote, S; Handgretinger, R; Mezger, M; Schleicher, S; Ureña-Bailén, G, 2021) |
| "Melanoma is an incurable disease for which alternative treatments to chemotherapy alone are sought." | 1.48 | Combining ultrasound and intratumoral administration of doxorubicin-loaded microspheres to enhance tumor cell killing. ( Carlsen, D; Do, AV; Geary, SM; Leelakanok, N; Martin, JA; Salem, AK; Seol, D; Tobias, P, 2018) |
| " These results meant that the removal of macrophages would decrease the nanoparticles accumulation in the liver and better the biodistribution and bioavailability of nanoparticles delivery systems." | 1.48 | Temporary suppression the sequestrated function of host macrophages for better nanoparticles tumor delivery. ( Han, T; Hao, J; Liu, J; Tang, H; Wang, M; Wang, X; Wang, Y; Zhuang, Q, 2018) |
| "Melanoma is a largely incurable skin malignancy owing to the underlying molecular and metabolic heterogeneity confounded by the development of resistance." | 1.42 | Targeting metabolic flexibility by simultaneously inhibiting respiratory complex I and lactate generation retards melanoma progression. ( Bhat, MK; Chaube, B; Malvi, P; Meena, AS; Mohammad, N; Singh, SV, 2015) |
| "The melanoma cell metastasis to lungs was prevented by intravenous co-injection of B16BL6 melanoma cells with 1." | 1.33 | The effect of poly (aspartic acid-co-lactic acid) nanospheres on the lung metastasis of B16BL6 melanoma cells by intravenous administration. ( Hara, K; Huang, CC; Kawashima, Y; Mimura, H; Miwa, N; Tsujimoto, H, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.39) | 18.7374 |
| 1990's | 8 (11.11) | 18.2507 |
| 2000's | 9 (12.50) | 29.6817 |
| 2010's | 41 (56.94) | 24.3611 |
| 2020's | 13 (18.06) | 2.80 |
| Authors | Studies |
|---|---|
| Lei, J | 1 |
| Yang, Y | 1 |
| Lu, Z | 1 |
| Pan, H | 1 |
| Fang, J | 1 |
| Jing, B | 1 |
| Chen, Y | 2 |
| Yin, L | 1 |
| Ren, Y | 1 |
| Kumar, A | 1 |
| Das, JK | 1 |
| Peng, HY | 1 |
| Wang, L | 1 |
| Balllard, D | 1 |
| Xiong, X | 1 |
| Ren, X | 1 |
| Zhang, Y | 2 |
| Yang, JM | 1 |
| Song, J | 1 |
| Longhitano, L | 1 |
| Giallongo, S | 1 |
| Orlando, L | 1 |
| Broggi, G | 1 |
| Longo, A | 1 |
| Russo, A | 1 |
| Caltabiano, R | 1 |
| Giallongo, C | 1 |
| Barbagallo, I | 1 |
| Di Rosa, M | 1 |
| Giuffrida, R | 1 |
| Parenti, R | 1 |
| Li Volti, G | 1 |
| Vicario, N | 1 |
| Tibullo, D | 1 |
| Farah, C | 1 |
| Neveu, MA | 1 |
| Bouzin, C | 1 |
| Knezevic, Z | 1 |
| Gallez, B | 1 |
| Leucci, E | 1 |
| Baurain, JF | 1 |
| Mignion, L | 1 |
| Jordan, BF | 1 |
| Chen, C | 1 |
| Zhang, X | 2 |
| Lee, WD | 1 |
| Leitner, BP | 1 |
| Zhu, W | 1 |
| Fosam, A | 1 |
| Li, Z | 2 |
| Gaspar, RC | 1 |
| Halberstam, AA | 1 |
| Robles, B | 1 |
| Rabinowitz, JD | 1 |
| Perry, RJ | 1 |
| Feng, H | 1 |
| Chen, W | 1 |
| Zhang, C | 1 |
| Jin, C | 1 |
| Dong, D | 1 |
| Yang, Z | 1 |
| Xia, R | 1 |
| Tao, S | 1 |
| Piao, M | 1 |
| Biagioni, A | 1 |
| Laurenzana, A | 1 |
| Chillà, A | 1 |
| Del Rosso, M | 1 |
| Andreucci, E | 1 |
| Poteti, M | 1 |
| Bani, D | 1 |
| Guasti, D | 1 |
| Fibbi, G | 1 |
| Margheri, F | 1 |
| Lees, H | 1 |
| Millan, M | 1 |
| Ahamed, F | 1 |
| Eskandari, R | 1 |
| Granlund, KL | 1 |
| Jeong, S | 1 |
| Keshari, KR | 1 |
| Suwabe, Y | 1 |
| Nakano, R | 1 |
| Namba, S | 1 |
| Yachiku, N | 1 |
| Kuji, M | 1 |
| Sugimura, M | 1 |
| Kitanaka, N | 1 |
| Kitanaka, T | 1 |
| Konno, T | 1 |
| Sugiya, H | 1 |
| Nakayama, T | 1 |
| Huang, WQ | 1 |
| Zhuang, QR | 1 |
| He, ZJ | 1 |
| Grote, S | 1 |
| Ureña-Bailén, G | 1 |
| Chan, KC | 1 |
| Baden, C | 1 |
| Mezger, M | 1 |
| Handgretinger, R | 1 |
| Schleicher, S | 1 |
| Weidmann, C | 1 |
| Pomerleau, J | 1 |
| Trudel-Vandal, L | 1 |
| Landreville, S | 1 |
| Chen, XY | 1 |
| Li, DF | 1 |
| Han, JC | 1 |
| Wang, B | 1 |
| Dong, ZP | 1 |
| Yu, LN | 1 |
| Pan, ZH | 1 |
| Qu, CJ | 1 |
| Sun, SG | 1 |
| Zheng, QS | 1 |
| Do, AV | 1 |
| Geary, SM | 2 |
| Seol, D | 1 |
| Tobias, P | 1 |
| Carlsen, D | 1 |
| Leelakanok, N | 1 |
| Martin, JA | 1 |
| Salem, AK | 3 |
| Matsuo, T | 1 |
| Sadzuka, Y | 1 |
| Kamenisch, Y | 2 |
| Ivanova, I | 1 |
| Drexler, K | 1 |
| Berneburg, M | 3 |
| Hao, J | 1 |
| Han, T | 1 |
| Wang, M | 1 |
| Zhuang, Q | 1 |
| Wang, X | 1 |
| Liu, J | 1 |
| Wang, Y | 2 |
| Tang, H | 1 |
| Yang, X | 2 |
| Zhao, H | 1 |
| Yang, J | 1 |
| Ma, Y | 1 |
| Liu, Z | 1 |
| Li, C | 1 |
| Wang, T | 1 |
| Yan, Z | 1 |
| Du, N | 1 |
| Lu, J | 1 |
| Liang, X | 1 |
| Gao, Y | 1 |
| Fu, G | 1 |
| Shen, Q | 2 |
| Hou, S | 1 |
| Zhao, L | 1 |
| Yu, J | 1 |
| Ng, C | 1 |
| Kong, X | 1 |
| Wu, D | 1 |
| Song, M | 1 |
| Shi, X | 1 |
| Xu, X | 1 |
| OuYang, WH | 1 |
| He, R | 1 |
| Zhao, XZ | 1 |
| Lee, T | 1 |
| Brunicardi, FC | 1 |
| Garcia, MA | 1 |
| Ribas, A | 1 |
| Lo, RS | 1 |
| Tseng, HR | 1 |
| Rosalia, RA | 1 |
| Silva, AL | 1 |
| Camps, M | 1 |
| Allam, A | 1 |
| Jiskoot, W | 1 |
| van der Burg, SH | 1 |
| Ossendorp, F | 1 |
| Oostendorp, J | 1 |
| Falck Miniotis, M | 1 |
| Arunan, V | 1 |
| Eykyn, TR | 1 |
| Marais, R | 1 |
| Workman, P | 1 |
| Leach, MO | 1 |
| Beloueche-Babari, M | 1 |
| Jianbo, G | 1 |
| Xue, L | 1 |
| Hongdan, Y | 1 |
| Zhaohui, T | 1 |
| Xing, T | 1 |
| Chenchen, C | 1 |
| Jinghua, X | 1 |
| Hui, X | 1 |
| Gottfried, E | 2 |
| Lang, SA | 1 |
| Renner, K | 3 |
| Bosserhoff, A | 1 |
| Gronwald, W | 1 |
| Rehli, M | 1 |
| Einhell, S | 1 |
| Gedig, I | 1 |
| Singer, K | 2 |
| Seilbeck, A | 1 |
| Mackensen, A | 2 |
| Grauer, O | 1 |
| Hau, P | 1 |
| Dettmer, K | 3 |
| Andreesen, R | 2 |
| Oefner, PJ | 3 |
| Kreutz, M | 2 |
| Tan, S | 2 |
| Sasada, T | 1 |
| Bershteyn, A | 1 |
| Yang, K | 1 |
| Ioji, T | 1 |
| Zhang, Z | 2 |
| Das, S | 2 |
| Das, J | 1 |
| Samadder, A | 1 |
| Paul, A | 1 |
| Khuda-Bukhsh, AR | 3 |
| Liang, R | 1 |
| Wang, J | 1 |
| Wu, X | 1 |
| Dong, L | 1 |
| Deng, R | 1 |
| Wang, K | 1 |
| Sullivan, M | 1 |
| Liu, S | 2 |
| Wu, M | 1 |
| Tao, J | 1 |
| Zhu, J | 1 |
| El Sayed, SM | 1 |
| Mohamed, WG | 1 |
| Seddik, MA | 1 |
| Ahmed, AS | 1 |
| Mahmoud, AG | 1 |
| Amer, WH | 1 |
| Helmy Nabo, MM | 1 |
| Hamed, AR | 1 |
| Ahmed, NS | 1 |
| Abd-Allah, AA | 1 |
| Guo, S | 1 |
| Lin, CM | 1 |
| Xu, Z | 1 |
| Miao, L | 1 |
| Huang, L | 1 |
| Wang, QM | 1 |
| Gao, Z | 1 |
| Fan, B | 1 |
| Kang, L | 1 |
| Huang, W | 2 |
| Jin, M | 1 |
| Zhao, Y | 1 |
| Lin, D | 1 |
| Wu, F | 1 |
| Guo, L | 1 |
| He, G | 1 |
| Ouyang, L | 1 |
| Song, X | 1 |
| Li, X | 1 |
| Makkouk, A | 1 |
| Joshi, VB | 1 |
| Wongrakpanich, A | 1 |
| Lemke, CD | 1 |
| Gross, BP | 1 |
| Weiner, GJ | 1 |
| Saluja, SS | 1 |
| Hanlon, DJ | 1 |
| Sharp, FA | 1 |
| Hong, E | 1 |
| Khalil, D | 1 |
| Robinson, E | 1 |
| Tigelaar, R | 1 |
| Fahmy, TM | 1 |
| Edelson, RL | 1 |
| Porcelli, L | 1 |
| Guida, G | 1 |
| Quatrale, AE | 1 |
| Cocco, T | 1 |
| Sidella, L | 1 |
| Maida, I | 1 |
| Iacobazzi, RM | 1 |
| Ferretta, A | 1 |
| Stolfa, DA | 1 |
| Strippoli, S | 1 |
| Guida, S | 1 |
| Tommasi, S | 1 |
| Guida, M | 1 |
| Azzariti, A | 1 |
| Zhang, FL | 1 |
| Pan, LL | 1 |
| Zhu, XL | 1 |
| Zhang, ZZ | 1 |
| Guo, Y | 1 |
| Wang, D | 1 |
| Song, Q | 1 |
| Wu, T | 1 |
| Zhuang, X | 1 |
| Bao, Y | 1 |
| Kong, M | 1 |
| Qi, Y | 1 |
| Chaube, B | 1 |
| Malvi, P | 1 |
| Singh, SV | 1 |
| Mohammad, N | 1 |
| Meena, AS | 1 |
| Bhat, MK | 1 |
| Wang, JW | 1 |
| Xu, JH | 1 |
| Li, J | 1 |
| Zhao, MH | 1 |
| Zhang, HF | 1 |
| Liu, DC | 1 |
| Zhou, X | 1 |
| Xu, H | 1 |
| Mi, Y | 1 |
| Mu, C | 1 |
| Wolfram, J | 1 |
| Deng, Z | 1 |
| Hu, TY | 1 |
| Liu, X | 1 |
| Blanco, E | 1 |
| Shen, H | 1 |
| Ferrari, M | 1 |
| Baban, TSA | 1 |
| Schuller, W | 1 |
| von Thaler, AK | 1 |
| Sinnberg, T | 1 |
| Metzler, G | 1 |
| Bauer, J | 1 |
| Schittek, B | 1 |
| Garbe, C | 1 |
| Rocken, M | 1 |
| Brand, A | 1 |
| Koehl, GE | 1 |
| Kolitzus, M | 1 |
| Schoenhammer, G | 1 |
| Thiel, A | 1 |
| Matos, C | 1 |
| Bruss, C | 1 |
| Klobuch, S | 1 |
| Peter, K | 1 |
| Kastenberger, M | 2 |
| Bogdan, C | 1 |
| Schleicher, U | 1 |
| Ullrich, E | 1 |
| Fichtner-Feigl, S | 1 |
| Kesselring, R | 1 |
| Mack, M | 1 |
| Ritter, U | 1 |
| Schmid, M | 1 |
| Blank, C | 1 |
| Hoffmann, P | 1 |
| Walenta, S | 2 |
| Geissler, EK | 1 |
| Pouyssegur, J | 1 |
| Villunger, A | 1 |
| Steven, A | 1 |
| Seliger, B | 1 |
| Schreml, S | 1 |
| Haferkamp, S | 1 |
| Kohl, E | 1 |
| Karrer, S | 1 |
| Herr, W | 1 |
| Mueller-Klieser, W | 2 |
| Kosmides, AK | 1 |
| Meyer, RA | 1 |
| Hickey, JW | 1 |
| Aje, K | 1 |
| Cheung, KN | 1 |
| Green, JJ | 1 |
| Schneck, JP | 1 |
| Ahmed, KK | 1 |
| Su, J | 1 |
| Chen, X | 1 |
| Kanekura, T | 1 |
| Hersey, P | 1 |
| Watts, RN | 1 |
| Zhang, XD | 1 |
| Hackett, J | 1 |
| Dietl, K | 1 |
| Timischl, B | 1 |
| Eberhart, K | 1 |
| Dorn, C | 1 |
| Hellerbrand, C | 1 |
| Kunz-Schughart, LA | 1 |
| Kreutz, MP | 1 |
| Cai, X | 1 |
| Choi, SW | 1 |
| Kim, C | 1 |
| Wang, LV | 1 |
| Xia, Y | 1 |
| Bhattacharyya, SS | 1 |
| Paul, S | 1 |
| Boujedaini, N | 1 |
| Mueller, M | 1 |
| Schlosser, E | 1 |
| Gander, B | 1 |
| Groettrup, M | 1 |
| Scott, DA | 1 |
| Richardson, AD | 1 |
| Filipp, FV | 1 |
| Knutzen, CA | 1 |
| Chiang, GG | 1 |
| Ronai, ZA | 1 |
| Osterman, AL | 1 |
| Smith, JW | 1 |
| Wheatley, MA | 1 |
| Cochran, MC | 1 |
| Eisenbrey, JR | 1 |
| Oum, KL | 1 |
| Wadajkar, AS | 1 |
| Bhavsar, Z | 1 |
| Ko, CY | 1 |
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| Lassau, N | 1 |
| Hara, K | 1 |
| Tsujimoto, H | 1 |
| Huang, CC | 1 |
| Kawashima, Y | 1 |
| Mimura, H | 1 |
| Miwa, N | 1 |
| Blüher, S | 1 |
| Schulz, M | 1 |
| Bierbach, U | 1 |
| Meixensberger, J | 1 |
| Tröbs, RB | 1 |
| Hirsch, W | 1 |
| Schober, R | 1 |
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| Siekmeyer, W | 1 |
| Tamulevicius, P | 1 |
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| Kroon, BB | 1 |
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| van Slooten, GW | 1 |
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| van Dongen, JA | 1 |
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| Eggermont, AM | 1 |
| Deutz, NE | 1 |
| de Vries, M | 1 |
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| Rofstad, EK | 1 |
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| Hohenberger, P | 1 |
| Beck, K | 1 |
| Schlag, PM | 1 |
| Dwarkanath, BS | 1 |
| Zolzer, F | 1 |
| Chandana, S | 1 |
| Bauch, T | 1 |
| Adhikari, JS | 1 |
| Muller, WU | 1 |
| Jain, V | 1 |
| Zhou, R | 1 |
| Bansal, N | 1 |
| Leeper, DB | 2 |
| Pickup, S | 1 |
| Glickson, JD | 1 |
| Burd, R | 1 |
| Wachsberger, PR | 1 |
| Biaglow, JE | 1 |
| Wahl, ML | 1 |
| Lee, I | 1 |
5 reviews available for lactic acid and Melanoma
| Article | Year |
|---|---|
UVA, metabolism and melanoma: UVA makes melanoma hungry for metastasis.
Topics: Animals; Cell Survival; DNA Damage; Glucose; Glycolysis; Humans; Lactic Acid; Melanoma; Mitogen-Acti | 2018 |
Safety and outcome of treatment of metastatic melanoma using 3-bromopyruvate: a concise literature review and case study.
Topics: Acetaminophen; Adult; Carcinoma, Hepatocellular; Disease Progression; Drug Therapy, Combination; Enz | 2014 |
UVA-Irradiation Induces Melanoma Invasion via the Enhanced Warburg Effect.
Topics: Blood Glucose; Cell Line, Tumor; Follow-Up Studies; Humans; Lactic Acid; Melanoma; Melanoma, Cutaneo | 2016 |
PLGA-loaded nanomedicines in melanoma treatment: Future prospect for efficient drug delivery.
Topics: Drug Delivery Systems; Humans; Lactic Acid; Melanoma; Nanomedicine; Nanoparticles; Polyglycolic Acid | 2016 |
Metabolic approaches to treatment of melanoma.
Topics: Adenosine Triphosphate; Glycolysis; Humans; L-Lactate Dehydrogenase; Lactic Acid; Melanoma; Metaboli | 2009 |
67 other studies available for lactic acid and Melanoma
| Article | Year |
|---|---|
Taming metabolic competition via glycolysis inhibition for safe and potent tumor immunotherapy.
Topics: CD8-Positive T-Lymphocytes; Dimethyl Fumarate; Glycolysis; Humans; Immunotherapy; Interleukin-2; Lac | 2022 |
Tumorous expression of NAC1 restrains antitumor immunity through the LDHA-mediated immune evasion.
Topics: Animals; Antigens, Neoplasm; Cytokines; Humans; Immune Evasion; Lactate Dehydrogenase 5; Lactic Acid | 2022 |
Lactate Rewrites the Metabolic Reprogramming of Uveal Melanoma Cells and Induces Quiescence Phenotype.
Topics: Cell Line, Tumor; Humans; Lactic Acid; Melanoma; Receptors, G-Protein-Coupled; Signal Transduction; | 2022 |
Hyperpolarized
Topics: Carbon Isotopes; Glucose; Heterografts; Humans; Immune Checkpoint Inhibitors; Lactic Acid; Melanoma; | 2023 |
Glycolysis regulator PFKP induces human melanoma cell proliferation and tumor growth.
Topics: Adenosine Triphosphate; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Glycolysis; Humans; La | 2023 |
Dichloroacetate as a novel pharmaceutical treatment for cancer-related fatigue in melanoma.
Topics: Animals; Dichloroacetic Acid; Fatigue; Lactic Acid; Melanoma; Mice; Quality of Life | 2023 |
Identification of lactylation gene CALML5 and its correlated lncRNAs in cutaneous melanoma by machine learning.
Topics: Calcium-Binding Proteins; Humans; Lactic Acid; Machine Learning; Melanoma; Melanoma, Cutaneous Malig | 2023 |
CircMYC Regulates Glycolysis and Cell Proliferation in Melanoma.
Topics: 3' Untranslated Regions; Antagomirs; Base Sequence; Cell Line, Tumor; Cell Proliferation; Glycolysis | 2020 |
uPAR Knockout Results in a Deep Glycolytic and OXPHOS Reprogramming in Melanoma and Colon Carcinoma Cell Lines.
Topics: Base Sequence; Cell Line, Tumor; Cell Respiration; Colonic Neoplasms; CRISPR-Associated Protein 9; D | 2020 |
Multi-sample measurement of hyperpolarized pyruvate-to-lactate flux in melanoma cells.
Topics: Cell Line, Tumor; Humans; Lactic Acid; Melanoma; Metabolic Flux Analysis; Mutation; Proto-Oncogene P | 2021 |
Involvement of GLUT1 and GLUT3 in the growth of canine melanoma cells.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Dogs; Glucose; Glucose Transporter Type 1; Glucose Tr | 2021 |
ILF3-AS1 promotes the aerobic glycolysis and proliferation of melanoma cells by regulating miR-493-5p/PDK1 pathway.
Topics: Cell Proliferation; Glucose; Glycolysis; Humans; Lactic Acid; Melanoma; MicroRNAs; Nuclear Factor 90 | 2022 |
In Vitro Evaluation of CD276-CAR NK-92 Functionality, Migration and Invasion Potential in the Presence of Immune Inhibitory Factors of the Tumor Microenvironment.
Topics: Antigens, Neoplasm; B7 Antigens; Cell Line, Tumor; Cell Movement; CRISPR-Cas Systems; Cytotoxicity, | 2021 |
Differential responses of choroidal melanocytes and uveal melanoma cells to low oxygen conditions.
Topics: Aged, 80 and over; Cell Count; Cell Nucleus Size; Cell Proliferation; Cell Survival; Cells, Cultured | 2017 |
Reprogramming induced by isoliquiritigenin diminishes melanoma cachexia through mTORC2-AKT-GSK3β signaling.
Topics: Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chalcones; Drug Synergism; Enzyme Inhibitors; Gene | 2017 |
Combining ultrasound and intratumoral administration of doxorubicin-loaded microspheres to enhance tumor cell killing.
Topics: Animals; Cell Line, Tumor; Combined Modality Therapy; Doxorubicin; Drug Liberation; Injections, Intr | 2018 |
Extracellular acidification by lactic acid suppresses glucose deprivation-induced cell death and autophagy in B16 melanoma cells.
Topics: Animals; Apoptosis; Autophagy; Cell Line, Tumor; Extracellular Fluid; Glucose; Hydrogen-Ion Concentr | 2018 |
Temporary suppression the sequestrated function of host macrophages for better nanoparticles tumor delivery.
Topics: Animals; Antineoplastic Agents; Biological Availability; Clodronic Acid; Drug Carriers; Lactic Acid; | 2018 |
MiR-150-5p regulates melanoma proliferation, invasion and metastasis via SIX1-mediated Warburg Effect.
Topics: 3' Untranslated Regions; Adenosine Triphosphate; Base Sequence; Cell Line, Tumor; Cell Proliferation | 2019 |
Hexokinase2 controls angiogenesis in melanoma by promoting aerobic glycolysis and activating the p38-MAPK signaling.
Topics: Apoptosis; Caspase 3; Caspase 9; Endostatins; Endothelial Cells; Glycolysis; Hexokinase; Human Umbil | 2019 |
Polymer nanofiber-embedded microchips for detection, isolation, and molecular analysis of single circulating melanoma cells.
Topics: Cell Line, Tumor; Cell Separation; Erythrocytes; Humans; Lactic Acid; Melanoma; Microfluidic Analyti | 2013 |
Efficient ex vivo induction of T cells with potent anti-tumor activity by protein antigen encapsulated in nanoparticles.
Topics: Animals; Antigen Presentation; Antigens; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; CD4- | 2013 |
MEK1/2 inhibition decreases lactate in BRAF-driven human cancer cells.
Topics: Animals; Antineoplastic Agents; Benzamides; Benzimidazoles; Cell Cycle Checkpoints; Cell Line, Tumor | 2013 |
The anti-melanoma efficiency of the intratumoral injection of cucurbitacin-loaded sustained-release carriers: a PLGA particle system.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cucurbitaceae; Delayed-Action Preparat | 2013 |
New aspects of an old drug--diclofenac targets MYC and glucose metabolism in tumor cells.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Transport; Carcinoma; Cell Line, Tumor; | 2013 |
Combinational delivery of lipid-enveloped polymeric nanoparticles carrying different peptides for anti-tumor immunotherapy.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cancer Vaccines; Cell Line, Tumor; Lactic A | 2014 |
Strategic formulation of apigenin-loaded PLGA nanoparticles for intracellular trafficking, DNA targeting and improved therapeutic effects in skin melanoma in vitro.
Topics: Apigenin; Apoptosis; Apoptotic Protease-Activating Factor 1; bcl-2-Associated X Protein; Caspase 3; | 2013 |
Multifunctional biodegradable polymer nanoparticles with uniform sizes: generation and in vitro anti-melanoma activity.
Topics: Biocompatible Materials; Biodegradation, Environmental; Cell Death; Cell Line, Tumor; Cell Survival; | 2013 |
Co-delivery of cisplatin and rapamycin for enhanced anticancer therapy through synergistic effects and microenvironment modulation.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Chromatography, High Pressure Liquid; C | 2014 |
Hybrid polymeric micelles based on bioactive polypeptides as pH-responsive delivery systems against melanoma.
Topics: Animals; Apoptosis; Cell Line, Tumor; Doxorubicin; Drug Delivery Systems; Female; Hydrogen-Ion Conce | 2014 |
Discovery and in vivo evaluation of novel RGD-modified lipid-polymer hybrid nanoparticles for targeted drug delivery.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cholesterol; Curcumin; Drug Carriers; D | 2014 |
Biodegradable microparticles loaded with doxorubicin and CpG ODN for in situ immunization against cancer.
Topics: Adjuvants, Immunologic; Animals; Antibiotics, Antineoplastic; Delayed-Action Preparations; Dendritic | 2015 |
Targeting human dendritic cells via DEC-205 using PLGA nanoparticles leads to enhanced cross-presentation of a melanoma-associated antigen.
Topics: Antigen Presentation; Antigens, CD; Cancer Vaccines; Dendritic Cells; Humans; Lactic Acid; Lectins, | 2014 |
Aurora kinase B inhibition reduces the proliferation of metastatic melanoma cells and enhances the response to chemotherapy.
Topics: Albumins; Apoptosis; Aurora Kinase B; Cell Line, Tumor; Cell Movement; Cell Nucleus Shape; Cell Prol | 2015 |
Preparation and characterization of injectable Mitoxantrone poly (lactic acid)/fullerene implants for in vivo chemo-photodynamic therapy.
Topics: Animals; Antineoplastic Agents; Chemistry, Pharmaceutical; Combined Modality Therapy; Drug Carriers; | 2015 |
Erythrocyte Membrane-Enveloped Polymeric Nanoparticles as Nanovaccine for Induction of Antitumor Immunity against Melanoma.
Topics: Animals; Antigen-Presenting Cells; Cancer Vaccines; Cell Line, Tumor; Cell Membrane; Dendritic Cells | 2015 |
Targeting metabolic flexibility by simultaneously inhibiting respiratory complex I and lactate generation retards melanoma progression.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Lin | 2015 |
Improvement of the Antitumor Efficacy of Intratumoral Administration of Cucurbitacin Poly(Lactic-co-Glycolic Acid) Microspheres Incorporated in In Situ-Forming Sucrose Acetate Isobutyrate Depots.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cucurbitacins; Delayed-Action Preparations; Drug Implant | 2016 |
A Micro/Nano Composite for Combination Treatment of Melanoma Lung Metastasis.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Combined Modality Therapy; Docetaxel; Drug Synergi | 2016 |
LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells.
Topics: Animals; Apoptosis; CD8-Positive T-Lymphocytes; Cell Count; Cell Line, Tumor; Cell Proliferation; Ce | 2016 |
Biomimetic biodegradable artificial antigen presenting cells synergize with PD-1 blockade to treat melanoma.
Topics: Absorbable Implants; Animals; Antibodies, Monoclonal; Antigen-Presenting Cells; Artificial Cells; Bi | 2017 |
Surface engineering tumor cells with adjuvant-loaded particles for use as cancer vaccines.
Topics: Adjuvants, Immunologic; Animals; Cancer Vaccines; Cell Line, Tumor; Cross-Linking Reagents; Drug Car | 2017 |
A CD147-targeting siRNA inhibits the proliferation, invasiveness, and VEGF production of human malignant melanoma cells by down-regulating glycolysis.
Topics: Basigin; Blotting, Western; Cell Line; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Enzyme | 2009 |
Lactic acid and acidification inhibit TNF secretion and glycolysis of human monocytes.
Topics: Acidosis, Lactic; Cell Line, Tumor; Cell Survival; Cells, Cultured; Coculture Techniques; Energy Met | 2010 |
Chronic label-free volumetric photoacoustic microscopy of melanoma cells in three-dimensional porous scaffolds.
Topics: Acoustics; Cell Proliferation; Diagnostic Imaging; Humans; Lactic Acid; Light; Melanoma; Microscopy; | 2010 |
Polymeric nanoparticle encapsulation of a naturally occurring plant scopoletin and its effects on human melanoma cell A375.
Topics: Apoptosis; Caspase 3; Coumarins; Down-Regulation; Humans; Imidazoles; Lactic Acid; Melanoma; Nanopar | 2010 |
Tumor eradication by immunotherapy with biodegradable PLGA microspheres--an alternative to incomplete Freund's adjuvant.
Topics: Animals; CD8-Positive T-Lymphocytes; Disease Models, Animal; Freund's Adjuvant; Immunotherapy; Lacti | 2011 |
Comparative metabolic flux profiling of melanoma cell lines: beyond the Warburg effect.
Topics: Cell Line, Tumor; Citric Acid Cycle; Fermentation; Gas Chromatography-Mass Spectrometry; Glucose; Gl | 2011 |
Cellular signal transduction can be induced by TRAIL conjugated to microcapsules.
Topics: Annexin A5; Apoptosis; Boronic Acids; Bortezomib; Capsules; Cell Line, Tumor; Contrast Media; Doxoru | 2012 |
Multifunctional particles for melanoma-targeted drug delivery.
Topics: Acrylic Resins; Animals; Cell Death; Drug Delivery Systems; Fibroblasts; Humans; Hydrodynamics; Lact | 2012 |
Doxorubicin-loaded highly porous large PLGA microparticles as a sustained- release inhalation system for the treatment of metastatic lung cancer.
Topics: Administration, Inhalation; Animals; Antibiotics, Antineoplastic; Capsules; Delayed-Action Preparati | 2012 |
Selective inhibition of respiration of pigmented S91 mouse melanomas by phenyl lactate, and the possibly related effects on growth.
Topics: Animals; Antimetabolites; Lactates; Lactic Acid; Melanoma; Mice; Skin Neoplasms | 1963 |
The inhibitory effect of glycolic acid and lactic acid on melanin synthesis in melanoma cells.
Topics: Animals; Blotting, Northern; Blotting, Western; Cell Division; Cell Line, Tumor; Dose-Response Relat | 2003 |
In vitro echogenicity characterization of poly[lactide-coglycolide] (plga) microparticles and preliminary in vivo ultrasound enhancement study for ultrasound contrast agent application.
Topics: Animals; Contrast Media; In Vitro Techniques; Lactic Acid; Melanoma; Mice; Microspheres; Particle Si | 2005 |
The effect of poly (aspartic acid-co-lactic acid) nanospheres on the lung metastasis of B16BL6 melanoma cells by intravenous administration.
Topics: Animals; Biocompatible Materials; Cell Line, Tumor; Delayed-Action Preparations; Injections, Intrave | 2006 |
Central lactic acidosis, hyperventilation, and respiratory alkalosis: leading clinical features in a 3-year-old boy with malignant meningeal melanoma.
Topics: Acidosis, Lactic; Alkalosis, Respiratory; Child, Preschool; Diagnosis, Differential; Fatal Outcome; | 2008 |
Metabolic imaging in tumours by means of bioluminescence.
Topics: Adenocarcinoma; Adenosine Triphosphate; Animals; Carcinoma, Squamous Cell; Cell Death; Colorectal Ne | 1995 |
Geographical mapping of metabolites in biological tissue with quantitative bioluminescence and single photon imaging.
Topics: Adenosine Triphosphate; Animals; Cell Survival; Cells, Cultured; Female; Frozen Sections; Glucose; H | 1993 |
Tyrosinase gene transcription and its control by melanogenic inhibitors.
Topics: Animals; Ascorbic Acid; Cell Line; Cricetinae; Glutathione; Humans; Lactates; Lactic Acid; Melanins; | 1993 |
Slow induction of gelatinase B mRNA by acidic culture conditions in mouse metastatic melanoma cells.
Topics: Animals; Base Sequence; Collagenases; Culture Media; Lactates; Lactic Acid; Matrix Metalloproteinase | 1996 |
Physiological implications of hyperbaric oxygen tensions in isolated limb perfusion using melphalan: a pilot study.
Topics: Adult; Aged; Chemotherapy, Cancer, Regional Perfusion; Extremities; Female; Gases; Humans; Hyperbari | 1996 |
TNF-alpha has no direct in vivo metabolic effect on human muscle.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amino Acids; Ammonia; Antineoplastic Agents, Alkylating; | 1997 |
Energy metabolism in human melanoma cells under hypoxic and acidic conditions in vitro.
Topics: Cell Hypoxia; Energy Metabolism; Glucose; Humans; Hydrogen-Ion Concentration; Lactic Acid; Melanoma; | 1997 |
[O2 utilization during hyperthermic extremity perfusion with rhTNF alpha and melphalan].
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Carbon Dioxide; Chemotherapy, Cancer, Re | 1997 |
Heterogeneity in 2-deoxy-D-glucose-induced modifications in energetics and radiation responses of human tumor cell lines.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Carcinoma, Squamous Cell; Deoxyglucose; DNA Damage; D | 2001 |
Enhancement of hyperglycemia-induced acidification of human melanoma xenografts with inhibitors of respiration and ion transport.
Topics: 3-Iodobenzylguanidine; Animals; Cell Respiration; Coumaric Acids; Glycolysis; Humans; Hydrogen-Ion C | 2001 |
Absence of Crabtree effect in human melanoma cells adapted to growth at low pH: reversal by respiratory inhibitors.
Topics: 3-Iodobenzylguanidine; Cell Cycle; Cell Division; Dose-Response Relationship, Drug; Glucose; Humans; | 2001 |