lactic acid has been researched along with Malignant Melanoma in 72 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A375 melanoma cancer cells were used for testing cellular entry and anticancer potentials of HMC and nano-7-hydroxy-6-methoxy coumarin (NHMC) through several standard protocols." | 7.76 | Polymeric nanoparticle encapsulation of a naturally occurring plant scopoletin and its effects on human melanoma cell A375. ( Bhattacharyya, SS; Boujedaini, N; Khuda-Bukhsh, AR; Paul, S, 2010) |
| " Measurement of pH in cerebrospinal fluid (CSF) yielded central lactic acidosis despite alkalosis in peripheral blood." | 7.74 | Central lactic acidosis, hyperventilation, and respiratory alkalosis: leading clinical features in a 3-year-old boy with malignant meningeal melanoma. ( Bierbach, U; Blüher, S; Hirsch, W; Kiess, W; Meixensberger, J; Schober, R; Schulz, M; Siekmeyer, W; Tröbs, RB, 2008) |
| "The melanoma cell metastasis to lungs was prevented by intravenous co-injection of B16BL6 melanoma cells with 1." | 5.33 | The effect of poly (aspartic acid-co-lactic acid) nanospheres on the lung metastasis of B16BL6 melanoma cells by intravenous administration. ( Hara, K; Huang, CC; Kawashima, Y; Mimura, H; Miwa, N; Tsujimoto, H, 2006) |
| " Here we show that LDHA-associated lactic acid accumulation in melanomas inhibits tumor surveillance by T and NK cells." | 3.83 | LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells. ( Berneburg, M; Blank, C; Bogdan, C; Brand, A; Bruss, C; Dettmer, K; Fichtner-Feigl, S; Geissler, EK; Haferkamp, S; Herr, W; Hoffmann, P; Karrer, S; Kastenberger, M; Kesselring, R; Klobuch, S; Koehl, GE; Kohl, E; Kolitzus, M; Kreutz, M; Mack, M; Mackensen, A; Matos, C; Mueller-Klieser, W; Oefner, PJ; Peter, K; Pouyssegur, J; Renner, K; Ritter, U; Schleicher, U; Schmid, M; Schoenhammer, G; Schreml, S; Seliger, B; Singer, K; Steven, A; Thiel, A; Ullrich, E; Villunger, A; Walenta, S, 2016) |
| "The bioactive polymer poly(L-glutamic acid)n-b-poly(D, L-lactic acid)m was synthesized and used to form doxorubicin-loaded hybrid polymeric micelles to treat melanoma." | 3.80 | Hybrid polymeric micelles based on bioactive polypeptides as pH-responsive delivery systems against melanoma. ( Fan, B; Gao, Z; Huang, W; Jin, M; Kang, L; Liu, S; Wang, QM, 2014) |
| "A375 melanoma cancer cells were used for testing cellular entry and anticancer potentials of HMC and nano-7-hydroxy-6-methoxy coumarin (NHMC) through several standard protocols." | 3.76 | Polymeric nanoparticle encapsulation of a naturally occurring plant scopoletin and its effects on human melanoma cell A375. ( Bhattacharyya, SS; Boujedaini, N; Khuda-Bukhsh, AR; Paul, S, 2010) |
| " Measurement of pH in cerebrospinal fluid (CSF) yielded central lactic acidosis despite alkalosis in peripheral blood." | 3.74 | Central lactic acidosis, hyperventilation, and respiratory alkalosis: leading clinical features in a 3-year-old boy with malignant meningeal melanoma. ( Bierbach, U; Blüher, S; Hirsch, W; Kiess, W; Meixensberger, J; Schober, R; Schulz, M; Siekmeyer, W; Tröbs, RB, 2008) |
| "The authors performed this study to evaluate the selective acidification of a human melanoma xenograft in mice with severe combined immunodeficiency with the induction of hyperglycemia (mean blood glucose level +/- standard error of the mean, 26 mmol/L +/- 1) and the intraperitoneal administration of metaiodobenzylguanidine (MIBG, 30 mg/kg), alpha-cyano-4-hydroxycinnamate (CNCn, 300 mg/kg), lonidamine (100 mg/kg), cariporide (HOE642, 160 mg/kg), or 4." | 3.71 | Enhancement of hyperglycemia-induced acidification of human melanoma xenografts with inhibitors of respiration and ion transport. ( Bansal, N; Glickson, JD; Leeper, DB; Pickup, S; Zhou, R, 2001) |
| " Thirty-three patients underwent ILP with rhTNF alpha and melphalan for melanoma or soft-tissue sarcoma." | 3.69 | [O2 utilization during hyperthermic extremity perfusion with rhTNF alpha and melphalan]. ( Beck, K; Haier, J; Hohenberger, P; Schlag, PM, 1997) |
| "Melanoma is a malignant tumor in which UVA (320-400 nm) radiation is considered to be an important risk factor." | 2.53 | UVA-Irradiation Induces Melanoma Invasion via the Enhanced Warburg Effect. ( Baban, TSA; Bauer, J; Berneburg, M; Garbe, C; Kamenisch, Y; Metzler, G; Rocken, M; Schittek, B; Schuller, W; Sinnberg, T; von Thaler, AK, 2016) |
| " Moreover, encapsulation protects the drug from deactivation by biological reactions and interactions with biomolecules, ensuring successful delivery and bioavailability for effective treatment." | 2.53 | PLGA-loaded nanomedicines in melanoma treatment: Future prospect for efficient drug delivery. ( Das, S; Khuda-Bukhsh, AR, 2016) |
| "Cutaneous melanoma is an aggressive and deadly cancer resulting from malignant transformation of cells involved in skin pigmentation." | 1.91 | Glycolysis regulator PFKP induces human melanoma cell proliferation and tumor growth. ( Chen, C; Zhang, X, 2023) |
| "Melanoma is the most lethal of all skin-related cancers with incidences continuously rising." | 1.62 | In Vitro Evaluation of CD276-CAR NK-92 Functionality, Migration and Invasion Potential in the Presence of Immune Inhibitory Factors of the Tumor Microenvironment. ( Baden, C; Chan, KC; Grote, S; Handgretinger, R; Mezger, M; Schleicher, S; Ureña-Bailén, G, 2021) |
| "Melanoma is an incurable disease for which alternative treatments to chemotherapy alone are sought." | 1.48 | Combining ultrasound and intratumoral administration of doxorubicin-loaded microspheres to enhance tumor cell killing. ( Carlsen, D; Do, AV; Geary, SM; Leelakanok, N; Martin, JA; Salem, AK; Seol, D; Tobias, P, 2018) |
| " These results meant that the removal of macrophages would decrease the nanoparticles accumulation in the liver and better the biodistribution and bioavailability of nanoparticles delivery systems." | 1.48 | Temporary suppression the sequestrated function of host macrophages for better nanoparticles tumor delivery. ( Han, T; Hao, J; Liu, J; Tang, H; Wang, M; Wang, X; Wang, Y; Zhuang, Q, 2018) |
| "Melanoma is a largely incurable skin malignancy owing to the underlying molecular and metabolic heterogeneity confounded by the development of resistance." | 1.42 | Targeting metabolic flexibility by simultaneously inhibiting respiratory complex I and lactate generation retards melanoma progression. ( Bhat, MK; Chaube, B; Malvi, P; Meena, AS; Mohammad, N; Singh, SV, 2015) |
| "The melanoma cell metastasis to lungs was prevented by intravenous co-injection of B16BL6 melanoma cells with 1." | 1.33 | The effect of poly (aspartic acid-co-lactic acid) nanospheres on the lung metastasis of B16BL6 melanoma cells by intravenous administration. ( Hara, K; Huang, CC; Kawashima, Y; Mimura, H; Miwa, N; Tsujimoto, H, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.39) | 18.7374 |
| 1990's | 8 (11.11) | 18.2507 |
| 2000's | 9 (12.50) | 29.6817 |
| 2010's | 41 (56.94) | 24.3611 |
| 2020's | 13 (18.06) | 2.80 |
| Authors | Studies |
|---|---|
| Lei, J | 1 |
| Yang, Y | 1 |
| Lu, Z | 1 |
| Pan, H | 1 |
| Fang, J | 1 |
| Jing, B | 1 |
| Chen, Y | 2 |
| Yin, L | 1 |
| Ren, Y | 1 |
| Kumar, A | 1 |
| Das, JK | 1 |
| Peng, HY | 1 |
| Wang, L | 1 |
| Balllard, D | 1 |
| Xiong, X | 1 |
| Ren, X | 1 |
| Zhang, Y | 2 |
| Yang, JM | 1 |
| Song, J | 1 |
| Longhitano, L | 1 |
| Giallongo, S | 1 |
| Orlando, L | 1 |
| Broggi, G | 1 |
| Longo, A | 1 |
| Russo, A | 1 |
| Caltabiano, R | 1 |
| Giallongo, C | 1 |
| Barbagallo, I | 1 |
| Di Rosa, M | 1 |
| Giuffrida, R | 1 |
| Parenti, R | 1 |
| Li Volti, G | 1 |
| Vicario, N | 1 |
| Tibullo, D | 1 |
| Farah, C | 1 |
| Neveu, MA | 1 |
| Bouzin, C | 1 |
| Knezevic, Z | 1 |
| Gallez, B | 1 |
| Leucci, E | 1 |
| Baurain, JF | 1 |
| Mignion, L | 1 |
| Jordan, BF | 1 |
| Chen, C | 1 |
| Zhang, X | 2 |
| Lee, WD | 1 |
| Leitner, BP | 1 |
| Zhu, W | 1 |
| Fosam, A | 1 |
| Li, Z | 2 |
| Gaspar, RC | 1 |
| Halberstam, AA | 1 |
| Robles, B | 1 |
| Rabinowitz, JD | 1 |
| Perry, RJ | 1 |
| Feng, H | 1 |
| Chen, W | 1 |
| Zhang, C | 1 |
| Jin, C | 1 |
| Dong, D | 1 |
| Yang, Z | 1 |
| Xia, R | 1 |
| Tao, S | 1 |
| Piao, M | 1 |
| Biagioni, A | 1 |
| Laurenzana, A | 1 |
| Chillà, A | 1 |
| Del Rosso, M | 1 |
| Andreucci, E | 1 |
| Poteti, M | 1 |
| Bani, D | 1 |
| Guasti, D | 1 |
| Fibbi, G | 1 |
| Margheri, F | 1 |
| Lees, H | 1 |
| Millan, M | 1 |
| Ahamed, F | 1 |
| Eskandari, R | 1 |
| Granlund, KL | 1 |
| Jeong, S | 1 |
| Keshari, KR | 1 |
| Suwabe, Y | 1 |
| Nakano, R | 1 |
| Namba, S | 1 |
| Yachiku, N | 1 |
| Kuji, M | 1 |
| Sugimura, M | 1 |
| Kitanaka, N | 1 |
| Kitanaka, T | 1 |
| Konno, T | 1 |
| Sugiya, H | 1 |
| Nakayama, T | 1 |
| Huang, WQ | 1 |
| Zhuang, QR | 1 |
| He, ZJ | 1 |
| Grote, S | 1 |
| Ureña-Bailén, G | 1 |
| Chan, KC | 1 |
| Baden, C | 1 |
| Mezger, M | 1 |
| Handgretinger, R | 1 |
| Schleicher, S | 1 |
| Weidmann, C | 1 |
| Pomerleau, J | 1 |
| Trudel-Vandal, L | 1 |
| Landreville, S | 1 |
| Chen, XY | 1 |
| Li, DF | 1 |
| Han, JC | 1 |
| Wang, B | 1 |
| Dong, ZP | 1 |
| Yu, LN | 1 |
| Pan, ZH | 1 |
| Qu, CJ | 1 |
| Sun, SG | 1 |
| Zheng, QS | 1 |
| Do, AV | 1 |
| Geary, SM | 2 |
| Seol, D | 1 |
| Tobias, P | 1 |
| Carlsen, D | 1 |
| Leelakanok, N | 1 |
| Martin, JA | 1 |
| Salem, AK | 3 |
| Matsuo, T | 1 |
| Sadzuka, Y | 1 |
| Kamenisch, Y | 2 |
| Ivanova, I | 1 |
| Drexler, K | 1 |
| Berneburg, M | 3 |
| Hao, J | 1 |
| Han, T | 1 |
| Wang, M | 1 |
| Zhuang, Q | 1 |
| Wang, X | 1 |
| Liu, J | 1 |
| Wang, Y | 2 |
| Tang, H | 1 |
| Yang, X | 2 |
| Zhao, H | 1 |
| Yang, J | 1 |
| Ma, Y | 1 |
| Liu, Z | 1 |
| Li, C | 1 |
| Wang, T | 1 |
| Yan, Z | 1 |
| Du, N | 1 |
| Lu, J | 1 |
| Liang, X | 1 |
| Gao, Y | 1 |
| Fu, G | 1 |
| Shen, Q | 2 |
| Hou, S | 1 |
| Zhao, L | 1 |
| Yu, J | 1 |
| Ng, C | 1 |
| Kong, X | 1 |
| Wu, D | 1 |
| Song, M | 1 |
| Shi, X | 1 |
| Xu, X | 1 |
| OuYang, WH | 1 |
| He, R | 1 |
| Zhao, XZ | 1 |
| Lee, T | 1 |
| Brunicardi, FC | 1 |
| Garcia, MA | 1 |
| Ribas, A | 1 |
| Lo, RS | 1 |
| Tseng, HR | 1 |
| Rosalia, RA | 1 |
| Silva, AL | 1 |
| Camps, M | 1 |
| Allam, A | 1 |
| Jiskoot, W | 1 |
| van der Burg, SH | 1 |
| Ossendorp, F | 1 |
| Oostendorp, J | 1 |
| Falck Miniotis, M | 1 |
| Arunan, V | 1 |
| Eykyn, TR | 1 |
| Marais, R | 1 |
| Workman, P | 1 |
| Leach, MO | 1 |
| Beloueche-Babari, M | 1 |
| Jianbo, G | 1 |
| Xue, L | 1 |
| Hongdan, Y | 1 |
| Zhaohui, T | 1 |
| Xing, T | 1 |
| Chenchen, C | 1 |
| Jinghua, X | 1 |
| Hui, X | 1 |
| Gottfried, E | 2 |
| Lang, SA | 1 |
| Renner, K | 3 |
| Bosserhoff, A | 1 |
| Gronwald, W | 1 |
| Rehli, M | 1 |
| Einhell, S | 1 |
| Gedig, I | 1 |
| Singer, K | 2 |
| Seilbeck, A | 1 |
| Mackensen, A | 2 |
| Grauer, O | 1 |
| Hau, P | 1 |
| Dettmer, K | 3 |
| Andreesen, R | 2 |
| Oefner, PJ | 3 |
| Kreutz, M | 2 |
| Tan, S | 2 |
| Sasada, T | 1 |
| Bershteyn, A | 1 |
| Yang, K | 1 |
| Ioji, T | 1 |
| Zhang, Z | 2 |
| Das, S | 2 |
| Das, J | 1 |
| Samadder, A | 1 |
| Paul, A | 1 |
| Khuda-Bukhsh, AR | 3 |
| Liang, R | 1 |
| Wang, J | 1 |
| Wu, X | 1 |
| Dong, L | 1 |
| Deng, R | 1 |
| Wang, K | 1 |
| Sullivan, M | 1 |
| Liu, S | 2 |
| Wu, M | 1 |
| Tao, J | 1 |
| Zhu, J | 1 |
| El Sayed, SM | 1 |
| Mohamed, WG | 1 |
| Seddik, MA | 1 |
| Ahmed, AS | 1 |
| Mahmoud, AG | 1 |
| Amer, WH | 1 |
| Helmy Nabo, MM | 1 |
| Hamed, AR | 1 |
| Ahmed, NS | 1 |
| Abd-Allah, AA | 1 |
| Guo, S | 1 |
| Lin, CM | 1 |
| Xu, Z | 1 |
| Miao, L | 1 |
| Huang, L | 1 |
| Wang, QM | 1 |
| Gao, Z | 1 |
| Fan, B | 1 |
| Kang, L | 1 |
| Huang, W | 2 |
| Jin, M | 1 |
| Zhao, Y | 1 |
| Lin, D | 1 |
| Wu, F | 1 |
| Guo, L | 1 |
| He, G | 1 |
| Ouyang, L | 1 |
| Song, X | 1 |
| Li, X | 1 |
| Makkouk, A | 1 |
| Joshi, VB | 1 |
| Wongrakpanich, A | 1 |
| Lemke, CD | 1 |
| Gross, BP | 1 |
| Weiner, GJ | 1 |
| Saluja, SS | 1 |
| Hanlon, DJ | 1 |
| Sharp, FA | 1 |
| Hong, E | 1 |
| Khalil, D | 1 |
| Robinson, E | 1 |
| Tigelaar, R | 1 |
| Fahmy, TM | 1 |
| Edelson, RL | 1 |
| Porcelli, L | 1 |
| Guida, G | 1 |
| Quatrale, AE | 1 |
| Cocco, T | 1 |
| Sidella, L | 1 |
| Maida, I | 1 |
| Iacobazzi, RM | 1 |
| Ferretta, A | 1 |
| Stolfa, DA | 1 |
| Strippoli, S | 1 |
| Guida, S | 1 |
| Tommasi, S | 1 |
| Guida, M | 1 |
| Azzariti, A | 1 |
| Zhang, FL | 1 |
| Pan, LL | 1 |
| Zhu, XL | 1 |
| Zhang, ZZ | 1 |
| Guo, Y | 1 |
| Wang, D | 1 |
| Song, Q | 1 |
| Wu, T | 1 |
| Zhuang, X | 1 |
| Bao, Y | 1 |
| Kong, M | 1 |
| Qi, Y | 1 |
| Chaube, B | 1 |
| Malvi, P | 1 |
| Singh, SV | 1 |
| Mohammad, N | 1 |
| Meena, AS | 1 |
| Bhat, MK | 1 |
| Wang, JW | 1 |
| Xu, JH | 1 |
| Li, J | 1 |
| Zhao, MH | 1 |
| Zhang, HF | 1 |
| Liu, DC | 1 |
| Zhou, X | 1 |
| Xu, H | 1 |
| Mi, Y | 1 |
| Mu, C | 1 |
| Wolfram, J | 1 |
| Deng, Z | 1 |
| Hu, TY | 1 |
| Liu, X | 1 |
| Blanco, E | 1 |
| Shen, H | 1 |
| Ferrari, M | 1 |
| Baban, TSA | 1 |
| Schuller, W | 1 |
| von Thaler, AK | 1 |
| Sinnberg, T | 1 |
| Metzler, G | 1 |
| Bauer, J | 1 |
| Schittek, B | 1 |
| Garbe, C | 1 |
| Rocken, M | 1 |
| Brand, A | 1 |
| Koehl, GE | 1 |
| Kolitzus, M | 1 |
| Schoenhammer, G | 1 |
| Thiel, A | 1 |
| Matos, C | 1 |
| Bruss, C | 1 |
| Klobuch, S | 1 |
| Peter, K | 1 |
| Kastenberger, M | 2 |
| Bogdan, C | 1 |
| Schleicher, U | 1 |
| Ullrich, E | 1 |
| Fichtner-Feigl, S | 1 |
| Kesselring, R | 1 |
| Mack, M | 1 |
| Ritter, U | 1 |
| Schmid, M | 1 |
| Blank, C | 1 |
| Hoffmann, P | 1 |
| Walenta, S | 2 |
| Geissler, EK | 1 |
| Pouyssegur, J | 1 |
| Villunger, A | 1 |
| Steven, A | 1 |
| Seliger, B | 1 |
| Schreml, S | 1 |
| Haferkamp, S | 1 |
| Kohl, E | 1 |
| Karrer, S | 1 |
| Herr, W | 1 |
| Mueller-Klieser, W | 2 |
| Kosmides, AK | 1 |
| Meyer, RA | 1 |
| Hickey, JW | 1 |
| Aje, K | 1 |
| Cheung, KN | 1 |
| Green, JJ | 1 |
| Schneck, JP | 1 |
| Ahmed, KK | 1 |
| Su, J | 1 |
| Chen, X | 1 |
| Kanekura, T | 1 |
| Hersey, P | 1 |
| Watts, RN | 1 |
| Zhang, XD | 1 |
| Hackett, J | 1 |
| Dietl, K | 1 |
| Timischl, B | 1 |
| Eberhart, K | 1 |
| Dorn, C | 1 |
| Hellerbrand, C | 1 |
| Kunz-Schughart, LA | 1 |
| Kreutz, MP | 1 |
| Cai, X | 1 |
| Choi, SW | 1 |
| Kim, C | 1 |
| Wang, LV | 1 |
| Xia, Y | 1 |
| Bhattacharyya, SS | 1 |
| Paul, S | 1 |
| Boujedaini, N | 1 |
| Mueller, M | 1 |
| Schlosser, E | 1 |
| Gander, B | 1 |
| Groettrup, M | 1 |
| Scott, DA | 1 |
| Richardson, AD | 1 |
| Filipp, FV | 1 |
| Knutzen, CA | 1 |
| Chiang, GG | 1 |
| Ronai, ZA | 1 |
| Osterman, AL | 1 |
| Smith, JW | 1 |
| Wheatley, MA | 1 |
| Cochran, MC | 1 |
| Eisenbrey, JR | 1 |
| Oum, KL | 1 |
| Wadajkar, AS | 1 |
| Bhavsar, Z | 1 |
| Ko, CY | 1 |
| Koppolu, B | 1 |
| Cui, W | 1 |
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| Nguyen, KT | 1 |
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| Kawashima, Y | 1 |
| Mimura, H | 1 |
| Miwa, N | 1 |
| Blüher, S | 1 |
| Schulz, M | 1 |
| Bierbach, U | 1 |
| Meixensberger, J | 1 |
| Tröbs, RB | 1 |
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| Hohenberger, P | 1 |
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| Schlag, PM | 1 |
| Dwarkanath, BS | 1 |
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| Bauch, T | 1 |
| Adhikari, JS | 1 |
| Muller, WU | 1 |
| Jain, V | 1 |
| Zhou, R | 1 |
| Bansal, N | 1 |
| Leeper, DB | 2 |
| Pickup, S | 1 |
| Glickson, JD | 1 |
| Burd, R | 1 |
| Wachsberger, PR | 1 |
| Biaglow, JE | 1 |
| Wahl, ML | 1 |
| Lee, I | 1 |
5 reviews available for lactic acid and Malignant Melanoma
| Article | Year |
|---|---|
UVA, metabolism and melanoma: UVA makes melanoma hungry for metastasis.
Topics: Animals; Cell Survival; DNA Damage; Glucose; Glycolysis; Humans; Lactic Acid; Melanoma; Mitogen-Acti | 2018 |
Safety and outcome of treatment of metastatic melanoma using 3-bromopyruvate: a concise literature review and case study.
Topics: Acetaminophen; Adult; Carcinoma, Hepatocellular; Disease Progression; Drug Therapy, Combination; Enz | 2014 |
UVA-Irradiation Induces Melanoma Invasion via the Enhanced Warburg Effect.
Topics: Blood Glucose; Cell Line, Tumor; Follow-Up Studies; Humans; Lactic Acid; Melanoma; Melanoma, Cutaneo | 2016 |
PLGA-loaded nanomedicines in melanoma treatment: Future prospect for efficient drug delivery.
Topics: Drug Delivery Systems; Humans; Lactic Acid; Melanoma; Nanomedicine; Nanoparticles; Polyglycolic Acid | 2016 |
Metabolic approaches to treatment of melanoma.
Topics: Adenosine Triphosphate; Glycolysis; Humans; L-Lactate Dehydrogenase; Lactic Acid; Melanoma; Metaboli | 2009 |
67 other studies available for lactic acid and Malignant Melanoma
| Article | Year |
|---|---|
Taming metabolic competition via glycolysis inhibition for safe and potent tumor immunotherapy.
Topics: CD8-Positive T-Lymphocytes; Dimethyl Fumarate; Glycolysis; Humans; Immunotherapy; Interleukin-2; Lac | 2022 |
Tumorous expression of NAC1 restrains antitumor immunity through the LDHA-mediated immune evasion.
Topics: Animals; Antigens, Neoplasm; Cytokines; Humans; Immune Evasion; Lactate Dehydrogenase 5; Lactic Acid | 2022 |
Lactate Rewrites the Metabolic Reprogramming of Uveal Melanoma Cells and Induces Quiescence Phenotype.
Topics: Cell Line, Tumor; Humans; Lactic Acid; Melanoma; Receptors, G-Protein-Coupled; Signal Transduction; | 2022 |
Hyperpolarized
Topics: Carbon Isotopes; Glucose; Heterografts; Humans; Immune Checkpoint Inhibitors; Lactic Acid; Melanoma; | 2023 |
Glycolysis regulator PFKP induces human melanoma cell proliferation and tumor growth.
Topics: Adenosine Triphosphate; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Glycolysis; Humans; La | 2023 |
Dichloroacetate as a novel pharmaceutical treatment for cancer-related fatigue in melanoma.
Topics: Animals; Dichloroacetic Acid; Fatigue; Lactic Acid; Melanoma; Mice; Quality of Life | 2023 |
Identification of lactylation gene CALML5 and its correlated lncRNAs in cutaneous melanoma by machine learning.
Topics: Calcium-Binding Proteins; Humans; Lactic Acid; Machine Learning; Melanoma; Melanoma, Cutaneous Malig | 2023 |
CircMYC Regulates Glycolysis and Cell Proliferation in Melanoma.
Topics: 3' Untranslated Regions; Antagomirs; Base Sequence; Cell Line, Tumor; Cell Proliferation; Glycolysis | 2020 |
uPAR Knockout Results in a Deep Glycolytic and OXPHOS Reprogramming in Melanoma and Colon Carcinoma Cell Lines.
Topics: Base Sequence; Cell Line, Tumor; Cell Respiration; Colonic Neoplasms; CRISPR-Associated Protein 9; D | 2020 |
Multi-sample measurement of hyperpolarized pyruvate-to-lactate flux in melanoma cells.
Topics: Cell Line, Tumor; Humans; Lactic Acid; Melanoma; Metabolic Flux Analysis; Mutation; Proto-Oncogene P | 2021 |
Involvement of GLUT1 and GLUT3 in the growth of canine melanoma cells.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Dogs; Glucose; Glucose Transporter Type 1; Glucose Tr | 2021 |
ILF3-AS1 promotes the aerobic glycolysis and proliferation of melanoma cells by regulating miR-493-5p/PDK1 pathway.
Topics: Cell Proliferation; Glucose; Glycolysis; Humans; Lactic Acid; Melanoma; MicroRNAs; Nuclear Factor 90 | 2022 |
In Vitro Evaluation of CD276-CAR NK-92 Functionality, Migration and Invasion Potential in the Presence of Immune Inhibitory Factors of the Tumor Microenvironment.
Topics: Antigens, Neoplasm; B7 Antigens; Cell Line, Tumor; Cell Movement; CRISPR-Cas Systems; Cytotoxicity, | 2021 |
Differential responses of choroidal melanocytes and uveal melanoma cells to low oxygen conditions.
Topics: Aged, 80 and over; Cell Count; Cell Nucleus Size; Cell Proliferation; Cell Survival; Cells, Cultured | 2017 |
Reprogramming induced by isoliquiritigenin diminishes melanoma cachexia through mTORC2-AKT-GSK3β signaling.
Topics: Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chalcones; Drug Synergism; Enzyme Inhibitors; Gene | 2017 |
Combining ultrasound and intratumoral administration of doxorubicin-loaded microspheres to enhance tumor cell killing.
Topics: Animals; Cell Line, Tumor; Combined Modality Therapy; Doxorubicin; Drug Liberation; Injections, Intr | 2018 |
Extracellular acidification by lactic acid suppresses glucose deprivation-induced cell death and autophagy in B16 melanoma cells.
Topics: Animals; Apoptosis; Autophagy; Cell Line, Tumor; Extracellular Fluid; Glucose; Hydrogen-Ion Concentr | 2018 |
Temporary suppression the sequestrated function of host macrophages for better nanoparticles tumor delivery.
Topics: Animals; Antineoplastic Agents; Biological Availability; Clodronic Acid; Drug Carriers; Lactic Acid; | 2018 |
MiR-150-5p regulates melanoma proliferation, invasion and metastasis via SIX1-mediated Warburg Effect.
Topics: 3' Untranslated Regions; Adenosine Triphosphate; Base Sequence; Cell Line, Tumor; Cell Proliferation | 2019 |
Hexokinase2 controls angiogenesis in melanoma by promoting aerobic glycolysis and activating the p38-MAPK signaling.
Topics: Apoptosis; Caspase 3; Caspase 9; Endostatins; Endothelial Cells; Glycolysis; Hexokinase; Human Umbil | 2019 |
Polymer nanofiber-embedded microchips for detection, isolation, and molecular analysis of single circulating melanoma cells.
Topics: Cell Line, Tumor; Cell Separation; Erythrocytes; Humans; Lactic Acid; Melanoma; Microfluidic Analyti | 2013 |
Efficient ex vivo induction of T cells with potent anti-tumor activity by protein antigen encapsulated in nanoparticles.
Topics: Animals; Antigen Presentation; Antigens; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; CD4- | 2013 |
MEK1/2 inhibition decreases lactate in BRAF-driven human cancer cells.
Topics: Animals; Antineoplastic Agents; Benzamides; Benzimidazoles; Cell Cycle Checkpoints; Cell Line, Tumor | 2013 |
The anti-melanoma efficiency of the intratumoral injection of cucurbitacin-loaded sustained-release carriers: a PLGA particle system.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cucurbitaceae; Delayed-Action Preparat | 2013 |
New aspects of an old drug--diclofenac targets MYC and glucose metabolism in tumor cells.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Transport; Carcinoma; Cell Line, Tumor; | 2013 |
Combinational delivery of lipid-enveloped polymeric nanoparticles carrying different peptides for anti-tumor immunotherapy.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cancer Vaccines; Cell Line, Tumor; Lactic A | 2014 |
Strategic formulation of apigenin-loaded PLGA nanoparticles for intracellular trafficking, DNA targeting and improved therapeutic effects in skin melanoma in vitro.
Topics: Apigenin; Apoptosis; Apoptotic Protease-Activating Factor 1; bcl-2-Associated X Protein; Caspase 3; | 2013 |
Multifunctional biodegradable polymer nanoparticles with uniform sizes: generation and in vitro anti-melanoma activity.
Topics: Biocompatible Materials; Biodegradation, Environmental; Cell Death; Cell Line, Tumor; Cell Survival; | 2013 |
Co-delivery of cisplatin and rapamycin for enhanced anticancer therapy through synergistic effects and microenvironment modulation.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Chromatography, High Pressure Liquid; C | 2014 |
Hybrid polymeric micelles based on bioactive polypeptides as pH-responsive delivery systems against melanoma.
Topics: Animals; Apoptosis; Cell Line, Tumor; Doxorubicin; Drug Delivery Systems; Female; Hydrogen-Ion Conce | 2014 |
Discovery and in vivo evaluation of novel RGD-modified lipid-polymer hybrid nanoparticles for targeted drug delivery.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cholesterol; Curcumin; Drug Carriers; D | 2014 |
Biodegradable microparticles loaded with doxorubicin and CpG ODN for in situ immunization against cancer.
Topics: Adjuvants, Immunologic; Animals; Antibiotics, Antineoplastic; Delayed-Action Preparations; Dendritic | 2015 |
Targeting human dendritic cells via DEC-205 using PLGA nanoparticles leads to enhanced cross-presentation of a melanoma-associated antigen.
Topics: Antigen Presentation; Antigens, CD; Cancer Vaccines; Dendritic Cells; Humans; Lactic Acid; Lectins, | 2014 |
Aurora kinase B inhibition reduces the proliferation of metastatic melanoma cells and enhances the response to chemotherapy.
Topics: Albumins; Apoptosis; Aurora Kinase B; Cell Line, Tumor; Cell Movement; Cell Nucleus Shape; Cell Prol | 2015 |
Preparation and characterization of injectable Mitoxantrone poly (lactic acid)/fullerene implants for in vivo chemo-photodynamic therapy.
Topics: Animals; Antineoplastic Agents; Chemistry, Pharmaceutical; Combined Modality Therapy; Drug Carriers; | 2015 |
Erythrocyte Membrane-Enveloped Polymeric Nanoparticles as Nanovaccine for Induction of Antitumor Immunity against Melanoma.
Topics: Animals; Antigen-Presenting Cells; Cancer Vaccines; Cell Line, Tumor; Cell Membrane; Dendritic Cells | 2015 |
Targeting metabolic flexibility by simultaneously inhibiting respiratory complex I and lactate generation retards melanoma progression.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Lin | 2015 |
Improvement of the Antitumor Efficacy of Intratumoral Administration of Cucurbitacin Poly(Lactic-co-Glycolic Acid) Microspheres Incorporated in In Situ-Forming Sucrose Acetate Isobutyrate Depots.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cucurbitacins; Delayed-Action Preparations; Drug Implant | 2016 |
A Micro/Nano Composite for Combination Treatment of Melanoma Lung Metastasis.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Combined Modality Therapy; Docetaxel; Drug Synergi | 2016 |
LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells.
Topics: Animals; Apoptosis; CD8-Positive T-Lymphocytes; Cell Count; Cell Line, Tumor; Cell Proliferation; Ce | 2016 |
Biomimetic biodegradable artificial antigen presenting cells synergize with PD-1 blockade to treat melanoma.
Topics: Absorbable Implants; Animals; Antibodies, Monoclonal; Antigen-Presenting Cells; Artificial Cells; Bi | 2017 |
Surface engineering tumor cells with adjuvant-loaded particles for use as cancer vaccines.
Topics: Adjuvants, Immunologic; Animals; Cancer Vaccines; Cell Line, Tumor; Cross-Linking Reagents; Drug Car | 2017 |
A CD147-targeting siRNA inhibits the proliferation, invasiveness, and VEGF production of human malignant melanoma cells by down-regulating glycolysis.
Topics: Basigin; Blotting, Western; Cell Line; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Enzyme | 2009 |
Lactic acid and acidification inhibit TNF secretion and glycolysis of human monocytes.
Topics: Acidosis, Lactic; Cell Line, Tumor; Cell Survival; Cells, Cultured; Coculture Techniques; Energy Met | 2010 |
Chronic label-free volumetric photoacoustic microscopy of melanoma cells in three-dimensional porous scaffolds.
Topics: Acoustics; Cell Proliferation; Diagnostic Imaging; Humans; Lactic Acid; Light; Melanoma; Microscopy; | 2010 |
Polymeric nanoparticle encapsulation of a naturally occurring plant scopoletin and its effects on human melanoma cell A375.
Topics: Apoptosis; Caspase 3; Coumarins; Down-Regulation; Humans; Imidazoles; Lactic Acid; Melanoma; Nanopar | 2010 |
Tumor eradication by immunotherapy with biodegradable PLGA microspheres--an alternative to incomplete Freund's adjuvant.
Topics: Animals; CD8-Positive T-Lymphocytes; Disease Models, Animal; Freund's Adjuvant; Immunotherapy; Lacti | 2011 |
Comparative metabolic flux profiling of melanoma cell lines: beyond the Warburg effect.
Topics: Cell Line, Tumor; Citric Acid Cycle; Fermentation; Gas Chromatography-Mass Spectrometry; Glucose; Gl | 2011 |
Cellular signal transduction can be induced by TRAIL conjugated to microcapsules.
Topics: Annexin A5; Apoptosis; Boronic Acids; Bortezomib; Capsules; Cell Line, Tumor; Contrast Media; Doxoru | 2012 |
Multifunctional particles for melanoma-targeted drug delivery.
Topics: Acrylic Resins; Animals; Cell Death; Drug Delivery Systems; Fibroblasts; Humans; Hydrodynamics; Lact | 2012 |
Doxorubicin-loaded highly porous large PLGA microparticles as a sustained- release inhalation system for the treatment of metastatic lung cancer.
Topics: Administration, Inhalation; Animals; Antibiotics, Antineoplastic; Capsules; Delayed-Action Preparati | 2012 |
Selective inhibition of respiration of pigmented S91 mouse melanomas by phenyl lactate, and the possibly related effects on growth.
Topics: Animals; Antimetabolites; Lactates; Lactic Acid; Melanoma; Mice; Skin Neoplasms | 1963 |
The inhibitory effect of glycolic acid and lactic acid on melanin synthesis in melanoma cells.
Topics: Animals; Blotting, Northern; Blotting, Western; Cell Division; Cell Line, Tumor; Dose-Response Relat | 2003 |
In vitro echogenicity characterization of poly[lactide-coglycolide] (plga) microparticles and preliminary in vivo ultrasound enhancement study for ultrasound contrast agent application.
Topics: Animals; Contrast Media; In Vitro Techniques; Lactic Acid; Melanoma; Mice; Microspheres; Particle Si | 2005 |
The effect of poly (aspartic acid-co-lactic acid) nanospheres on the lung metastasis of B16BL6 melanoma cells by intravenous administration.
Topics: Animals; Biocompatible Materials; Cell Line, Tumor; Delayed-Action Preparations; Injections, Intrave | 2006 |
Central lactic acidosis, hyperventilation, and respiratory alkalosis: leading clinical features in a 3-year-old boy with malignant meningeal melanoma.
Topics: Acidosis, Lactic; Alkalosis, Respiratory; Child, Preschool; Diagnosis, Differential; Fatal Outcome; | 2008 |
Metabolic imaging in tumours by means of bioluminescence.
Topics: Adenocarcinoma; Adenosine Triphosphate; Animals; Carcinoma, Squamous Cell; Cell Death; Colorectal Ne | 1995 |
Geographical mapping of metabolites in biological tissue with quantitative bioluminescence and single photon imaging.
Topics: Adenosine Triphosphate; Animals; Cell Survival; Cells, Cultured; Female; Frozen Sections; Glucose; H | 1993 |
Tyrosinase gene transcription and its control by melanogenic inhibitors.
Topics: Animals; Ascorbic Acid; Cell Line; Cricetinae; Glutathione; Humans; Lactates; Lactic Acid; Melanins; | 1993 |
Slow induction of gelatinase B mRNA by acidic culture conditions in mouse metastatic melanoma cells.
Topics: Animals; Base Sequence; Collagenases; Culture Media; Lactates; Lactic Acid; Matrix Metalloproteinase | 1996 |
Physiological implications of hyperbaric oxygen tensions in isolated limb perfusion using melphalan: a pilot study.
Topics: Adult; Aged; Chemotherapy, Cancer, Regional Perfusion; Extremities; Female; Gases; Humans; Hyperbari | 1996 |
TNF-alpha has no direct in vivo metabolic effect on human muscle.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amino Acids; Ammonia; Antineoplastic Agents, Alkylating; | 1997 |
Energy metabolism in human melanoma cells under hypoxic and acidic conditions in vitro.
Topics: Cell Hypoxia; Energy Metabolism; Glucose; Humans; Hydrogen-Ion Concentration; Lactic Acid; Melanoma; | 1997 |
[O2 utilization during hyperthermic extremity perfusion with rhTNF alpha and melphalan].
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Carbon Dioxide; Chemotherapy, Cancer, Re | 1997 |
Heterogeneity in 2-deoxy-D-glucose-induced modifications in energetics and radiation responses of human tumor cell lines.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Carcinoma, Squamous Cell; Deoxyglucose; DNA Damage; D | 2001 |
Enhancement of hyperglycemia-induced acidification of human melanoma xenografts with inhibitors of respiration and ion transport.
Topics: 3-Iodobenzylguanidine; Animals; Cell Respiration; Coumaric Acids; Glycolysis; Humans; Hydrogen-Ion C | 2001 |
Absence of Crabtree effect in human melanoma cells adapted to growth at low pH: reversal by respiratory inhibitors.
Topics: 3-Iodobenzylguanidine; Cell Cycle; Cell Division; Dose-Response Relationship, Drug; Glucose; Humans; | 2001 |