lactic acid has been researched along with Malaria, Falciparum in 30 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Malaria, Falciparum: Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fifty-six adult patients with severe malaria and high parasitemia admitted to a referral hospital in Bangladesh were randomized to receive a single dose of levamisole hydrochloride (150 mg) or no adjuvant to antimalarial treatment with intravenous artesunate." | 9.19 | Randomized controlled trial of levamisole hydrochloride as adjunctive therapy in severe falciparum malaria with high parasitemia. ( Abul Faiz, M; Bin Yunus, E; Charunwatthana, P; Chotivanich, K; Day, NP; Dondorp, AM; Eastaugh, A; Ghose, A; Hanson, J; Hassan, MU; Ho, M; Hoque, G; Hossain, MA; Islam, F; Lacey, R; Lee, SJ; Maude, RJ; Plewes, K; Rahman, R; Schlatter, J; Silamut, K; Tarning, J; White, NJ, 2014) |
| " Plasmodium falciparum infection can cause severe malaria anaemia (SMA) with insufficient tissue oxygenation, lactic acidosis and death." | 7.88 | Mitochondrial gene sequence variants in children with severe malaria anaemia with or without lactic acidosis: a case control study. ( Amr, SS; Cserti-Gazdewich, C; Dhabangi, A; Dzik, W; Fowler, C; Musoke, C; Sharma, H, 2018) |
| "Fifty-six adult patients with severe malaria and high parasitemia admitted to a referral hospital in Bangladesh were randomized to receive a single dose of levamisole hydrochloride (150 mg) or no adjuvant to antimalarial treatment with intravenous artesunate." | 5.19 | Randomized controlled trial of levamisole hydrochloride as adjunctive therapy in severe falciparum malaria with high parasitemia. ( Abul Faiz, M; Bin Yunus, E; Charunwatthana, P; Chotivanich, K; Day, NP; Dondorp, AM; Eastaugh, A; Ghose, A; Hanson, J; Hassan, MU; Ho, M; Hoque, G; Hossain, MA; Islam, F; Lacey, R; Lee, SJ; Maude, RJ; Plewes, K; Rahman, R; Schlatter, J; Silamut, K; Tarning, J; White, NJ, 2014) |
| "Children with severe malaria often present with lactic acidosis and hypoglycemia." | 5.09 | Glucose and lactate kinetics in children with severe malaria. ( Agbenyega, T; Angus, BJ; Baffoe-Bonnie, B; Bedu-Addo, G; Guyton, T; Krishna, S; Stacpoole, PW, 2000) |
| "Amino acid derangements are common in severe falciparum malaria and have been associated with endothelial dysfunction (L-arginine), metabolic acidosis (alanine and lactate), and disease severity (phenylalanine and tryptophan metabolites)." | 3.91 | Amino acid derangements in adults with severe falciparum malaria. ( Apinan, S; Barua, A; Day, NPJ; Dondorp, AM; Dutta, AK; Ghose, A; Hossain, A; Kingston, HW; Leopold, SJ; Paul, S; Plewes, KA; Sattar, A; Tarning, J; White, NJ; Winterberg, M, 2019) |
| " Plasmodium falciparum infection can cause severe malaria anaemia (SMA) with insufficient tissue oxygenation, lactic acidosis and death." | 3.88 | Mitochondrial gene sequence variants in children with severe malaria anaemia with or without lactic acidosis: a case control study. ( Amr, SS; Cserti-Gazdewich, C; Dhabangi, A; Dzik, W; Fowler, C; Musoke, C; Sharma, H, 2018) |
| "Recovery of endothelial function in severe malaria is associated with recovery from hypoargininemia and lactic acidosis." | 3.74 | Recovery of endothelial function in severe falciparum malaria: relationship with improvement in plasma L-arginine and blood lactate concentrations. ( Anstey, NM; Celermajer, DS; Darcy, CJ; Duffull, SB; Gitawati, R; Granger, DL; Kenangalem, E; Lampah, DA; Lopansri, BK; McNeil, YR; Price, RN; Tjitra, E; Weinberg, JB; Yeo, TW, 2008) |
| "Development of hypotensive shock or pulmonary edema within 24 hours after enrollment were not related to the volume of fluid administration." | 1.56 | Associations Between Restrictive Fluid Management and Renal Function and Tissue Perfusion in Adults With Severe Falciparum Malaria: A Prospective Observational Study. ( Alam, S; Charunwatthana, P; Day, NPJ; Dey, C; Dondorp, AM; Faiz, MA; Ghose, A; Herdman, MT; Hossain, MA; Ishioka, H; Kingston, HWF; Leopold, SJ; Mahanta, K; Maude, RJ; Mohanty, A; Mohanty, S; Pattnaik, R; Plewes, K; Srinamon, K; White, NJ, 2020) |
| "Severe falciparum malaria is commonly complicated by metabolic acidosis." | 1.42 | The role of previously unmeasured organic acids in the pathogenesis of severe malaria. ( Charunwatthana, P; Chotinavich, K; Day, NP; Dondorp, AM; Douthwaite, S; Faiz, MA; Ghose, A; Hassan, MM; Herdman, MT; Hossain, MA; Kingston, HW; Leepipatpiboon, N; Leopold, SJ; Maude, RJ; Mishra, S; Mohanty, S; Plewes, K; Silamut, K; Sriboonvorakul, N; Tarning, J; White, NJ; Woodrow, CJ, 2015) |
| "Lactic acidosis is a consistent predictor of mortality owing to severe infectious disease, but its detection in low-income settings is limited to the clinical sign of "deep breathing" because of the lack of accessible technology for its measurement." | 1.37 | Point-of-care measurement of blood lactate in children admitted with febrile illness to an African District Hospital. ( Amos, B; Hendriksen, IC; Mtove, G; Muro, F; Nadjm, B; Reyburn, H; Todd, J, 2011) |
| "Children with coma and respiratory distress (CM + RD) had greater evidence of renal dysfunction, lower mean pH and higher mean plasma osmolality than those with respiratory distress (RD) or coma (CM) as isolated findings (mean urea 10." | 1.30 | Acidosis in severe childhood malaria. ( English, M; Lowe, B; Marsh, K; Mosobo, M; Obiero, J; Sauerwein, R; Waruiru, C, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (20.00) | 18.2507 |
| 2000's | 10 (33.33) | 29.6817 |
| 2010's | 10 (33.33) | 24.3611 |
| 2020's | 4 (13.33) | 2.80 |
| Authors | Studies |
|---|---|
| Peng, X | 1 |
| Wang, N | 1 |
| Zhu, A | 1 |
| Xu, H | 1 |
| Li, J | 1 |
| Zhou, Y | 1 |
| Wang, C | 1 |
| Xiao, Q | 1 |
| Guo, L | 1 |
| Liu, F | 1 |
| Jia, ZJ | 1 |
| Duan, H | 1 |
| Hu, J | 1 |
| Yuan, W | 1 |
| Geng, J | 1 |
| Yan, C | 1 |
| Jiang, X | 1 |
| Deng, D | 1 |
| Anagu, LO | 1 |
| Hulse, DR | 1 |
| Horrocks, PD | 1 |
| Chakravorty, SJ | 1 |
| Ishioka, H | 1 |
| Plewes, K | 3 |
| Pattnaik, R | 1 |
| Kingston, HWF | 1 |
| Leopold, SJ | 3 |
| Herdman, MT | 2 |
| Mahanta, K | 1 |
| Mohanty, A | 2 |
| Dey, C | 1 |
| Alam, S | 1 |
| Srinamon, K | 1 |
| Maude, RJ | 3 |
| White, NJ | 8 |
| Day, NPJ | 2 |
| Hossain, MA | 3 |
| Faiz, MA | 2 |
| Charunwatthana, P | 3 |
| Mohanty, S | 2 |
| Ghose, A | 4 |
| Dondorp, AM | 5 |
| West, R | 1 |
| Sullivan, DJ | 1 |
| Fowler, C | 1 |
| Cserti-Gazdewich, C | 1 |
| Dhabangi, A | 1 |
| Musoke, C | 1 |
| Sharma, H | 1 |
| Amr, SS | 1 |
| Dzik, W | 1 |
| Apinan, S | 1 |
| Kingston, HW | 2 |
| Plewes, KA | 1 |
| Hossain, A | 1 |
| Dutta, AK | 1 |
| Paul, S | 1 |
| Barua, A | 1 |
| Sattar, A | 1 |
| Tarning, J | 3 |
| Winterberg, M | 1 |
| Cunnington, AJ | 1 |
| Bretscher, MT | 1 |
| Nogaro, SI | 1 |
| Riley, EM | 1 |
| Walther, M | 2 |
| Silamut, K | 2 |
| Ho, M | 1 |
| Abul Faiz, M | 1 |
| Rahman, R | 1 |
| Hassan, MU | 1 |
| Bin Yunus, E | 1 |
| Hoque, G | 1 |
| Islam, F | 1 |
| Hanson, J | 1 |
| Schlatter, J | 1 |
| Lacey, R | 1 |
| Eastaugh, A | 1 |
| Lee, SJ | 1 |
| Chotivanich, K | 1 |
| Day, NP | 4 |
| Wu, B | 1 |
| Rambow, J | 1 |
| Bock, S | 1 |
| Holm-Bertelsen, J | 1 |
| Wiechert, M | 1 |
| Soares, AB | 1 |
| Spielmann, T | 1 |
| Beitz, E | 1 |
| Kumar, R | 1 |
| Ledet, G | 1 |
| Graves, R | 1 |
| Datta, D | 1 |
| Robinson, S | 1 |
| Bansal, GP | 1 |
| Mandal, T | 1 |
| Kumar, N | 1 |
| Sriboonvorakul, N | 1 |
| Douthwaite, S | 1 |
| Hassan, MM | 1 |
| Woodrow, CJ | 1 |
| Chotinavich, K | 1 |
| Mishra, S | 1 |
| Leepipatpiboon, N | 1 |
| Yeo, TW | 1 |
| Lampah, DA | 1 |
| Gitawati, R | 1 |
| Tjitra, E | 1 |
| Kenangalem, E | 1 |
| McNeil, YR | 1 |
| Darcy, CJ | 1 |
| Granger, DL | 1 |
| Weinberg, JB | 1 |
| Lopansri, BK | 1 |
| Price, RN | 1 |
| Duffull, SB | 1 |
| Celermajer, DS | 1 |
| Anstey, NM | 1 |
| te Witt, R | 1 |
| van Wolfswinkel, ME | 1 |
| Petit, PL | 1 |
| van Hellemond, JJ | 1 |
| Koelewijn, R | 1 |
| van Belkum, A | 1 |
| van Genderen, PJ | 1 |
| Mtove, G | 1 |
| Nadjm, B | 1 |
| Hendriksen, IC | 1 |
| Amos, B | 1 |
| Muro, F | 1 |
| Todd, J | 1 |
| Reyburn, H | 1 |
| Merrick, CJ | 1 |
| Huttenhower, C | 1 |
| Buckee, C | 1 |
| Amambua-Ngwa, A | 1 |
| Gomez-Escobar, N | 1 |
| Conway, DJ | 1 |
| Duraisingh, MT | 1 |
| Duranton, C | 1 |
| Huber, SM | 1 |
| Tanneur, V | 1 |
| Brand, VB | 1 |
| Akkaya, C | 1 |
| Shumilina, EV | 1 |
| Sandu, CD | 1 |
| Lang, F | 1 |
| van Thien, H | 1 |
| Weverling, GJ | 1 |
| Ackermans, MT | 1 |
| canh Hung, N | 1 |
| Endert, E | 2 |
| Kager, PA | 1 |
| Sauerwein, HP | 2 |
| Chau, TT | 2 |
| Phu, NH | 2 |
| Mai, NT | 2 |
| Loc, PP | 2 |
| Chuong, LV | 2 |
| Sinh, DX | 2 |
| Taylor, A | 1 |
| Hien, TT | 2 |
| Newton, CR | 2 |
| Valim, C | 1 |
| Krishna, S | 2 |
| Wypij, D | 1 |
| Olola, C | 1 |
| Agbenyega, T | 2 |
| Taylor, TE | 1 |
| Casals-Pascual, C | 1 |
| Kai, O | 1 |
| Lowe, B | 2 |
| English, M | 2 |
| Williams, TN | 1 |
| Maitland, K | 1 |
| Peshu, N | 2 |
| Roberts, DJ | 1 |
| Pukrittayakamee, S | 2 |
| Davis, TM | 2 |
| Supanaranond, W | 2 |
| Crawley, J | 1 |
| Nagachinta, B | 1 |
| Williamson, DH | 2 |
| Lando, G | 1 |
| Djiogue, R | 1 |
| Djoumessi, S | 1 |
| Joynt, G | 1 |
| Doedens, L | 1 |
| Lipman, J | 1 |
| Bothma, P | 1 |
| Dekker, E | 1 |
| Hellerstein, MK | 1 |
| Romijn, JA | 1 |
| Neese, RA | 1 |
| Marsh, K | 2 |
| Sauerwein, R | 1 |
| Waruiru, C | 1 |
| Mosobo, M | 1 |
| Obiero, J | 1 |
| Angus, BJ | 1 |
| Bedu-Addo, G | 1 |
| Baffoe-Bonnie, B | 1 |
| Guyton, T | 1 |
| Stacpoole, PW | 1 |
| Holloway, P | 1 |
| Elliott, JL | 1 |
| Saliba, KJ | 1 |
| Kirk, K | 1 |
| Rosas, JE | 1 |
| Pedraz, JL | 1 |
| Hernández, RM | 1 |
| Gascón, AR | 1 |
| Igartua, M | 1 |
| Guzmán, F | 1 |
| Rodríguez, R | 1 |
| Cortés, J | 1 |
| Patarroyo, ME | 1 |
| Looareesuwan, S | 1 |
| Desakorn, V | 1 |
| Chaivisuth, B | 1 |
4 trials available for lactic acid and Malaria, Falciparum
| Article | Year |
|---|---|
Randomized controlled trial of levamisole hydrochloride as adjunctive therapy in severe falciparum malaria with high parasitemia.
Topics: Adult; Antimalarials; Female; Humans; Kaplan-Meier Estimate; Lactic Acid; Levamisole; Malaria, Falci | 2014 |
FFAs are not involved in regulation of gluconeogenesis and glycogenolysis in adults with uncomplicated P. falciparum malaria.
Topics: Adult; Alanine; Fatty Acids, Nonesterified; Female; Gluconeogenesis; Glucose; Glycogen; Humans; Hypo | 2004 |
Unidentified acids of strong prognostic significance in severe malaria.
Topics: Acid-Base Equilibrium; Acidosis; Adolescent; Adult; Aged; Cohort Studies; Creatinine; Critical Care; | 2004 |
Glucose and lactate kinetics in children with severe malaria.
Topics: Acidosis, Lactic; Antimalarials; Artemisinins; Artesunate; Blood Glucose; Child; Child, Preschool; D | 2000 |
26 other studies available for lactic acid and Malaria, Falciparum
| Article | Year |
|---|---|
Structural characterization of the Plasmodium falciparum lactate transporter PfFNT alone and in complex with antimalarial compound MMV007839 reveals its inhibition mechanism.
Topics: Antimalarials; Cryoelectron Microscopy; Formates; Lactic Acid; Malaria, Falciparum; Monocarboxylic A | 2021 |
Alteration of the expression of sirtuins and var genes by heat shock in the malaria parasite Plasmodium falciparum.
Topics: Animals; Heat-Shock Response; Humans; Kenya; Lactic Acid; Malaria, Falciparum; Parasites; Plasmodium | 2022 |
Associations Between Restrictive Fluid Management and Renal Function and Tissue Perfusion in Adults With Severe Falciparum Malaria: A Prospective Observational Study.
Topics: Acute Kidney Injury; Adult; Female; Fluid Therapy; Humans; Kidney Function Tests; Lactic Acid; Malar | 2020 |
Lactic Acid Supplementation Increases Quantity and Quality of Gametocytes in Plasmodium falciparum Culture.
Topics: Animals; Anopheles; Dietary Supplements; Gene Expression; Genes, Reporter; Humans; Lactic Acid; Mala | 2020 |
Mitochondrial gene sequence variants in children with severe malaria anaemia with or without lactic acidosis: a case control study.
Topics: Acidosis, Lactic; Anemia; Case-Control Studies; Child, Preschool; DNA, Mitochondrial; Female; Humans | 2018 |
Amino acid derangements in adults with severe falciparum malaria.
Topics: Acidosis; Adult; Amino Acids; Arginine; Bangladesh; Female; Humans; Lactic Acid; Malaria, Falciparum | 2019 |
Comparison of parasite sequestration in uncomplicated and severe childhood Plasmodium falciparum malaria.
Topics: Antigens, Protozoan; Case-Control Studies; Child; Child, Preschool; Erythrocytes; Female; Humans; La | 2013 |
Identity of a Plasmodium lactate/H(+) symporter structurally unrelated to human transporters.
Topics: Animals; Biological Transport; Cell Membrane; Erythrocytes; Fluorescence; Glycolysis; Green Fluoresc | 2015 |
Potent Functional Immunogenicity of Plasmodium falciparum Transmission-Blocking Antigen (Pfs25) Delivered with Nanoemulsion and Porous Polymeric Nanoparticles.
Topics: Animals; Antibody Formation; Emulsions; Female; Immunization; Lactic Acid; Malaria Vaccines; Malaria | 2015 |
The role of previously unmeasured organic acids in the pathogenesis of severe malaria.
Topics: 3-Hydroxybutyric Acid; Acidosis; Adolescent; Adult; Aged; Chromatography, Liquid; Female; Humans; Hy | 2015 |
Recovery of endothelial function in severe falciparum malaria: relationship with improvement in plasma L-arginine and blood lactate concentrations.
Topics: Acidosis; Adult; Arginine; Biological Availability; Endothelium, Vascular; Humans; Lactic Acid; Mala | 2008 |
Neopterin and procalcitonin are suitable biomarkers for exclusion of severe Plasmodium falciparum disease at the initial clinical assessment of travellers with imported malaria.
Topics: Adolescent; Adult; Aged; Biomarkers; Calcitonin; Calcitonin Gene-Related Peptide; Child; Female; Hum | 2010 |
Point-of-care measurement of blood lactate in children admitted with febrile illness to an African District Hospital.
Topics: Adolescent; Anemia; Bacterial Infections; Child; Child, Preschool; Cohort Studies; Female; Fever; Ho | 2011 |
Epigenetic dysregulation of virulence gene expression in severe Plasmodium falciparum malaria.
Topics: Epigenomics; Gene Expression; Gene Knockout Techniques; Host-Parasite Interactions; Humans; Lactic A | 2012 |
Organic osmolyte permeabilities of the malaria-induced anion conductances in human erythrocytes.
Topics: Animals; Anions; Erythrocytes; Humans; Hypertonic Solutions; Hypotonic Solutions; Isotonic Solutions | 2004 |
The prognostic value of measures of acid/base balance in pediatric falciparum malaria, compared with other clinical and laboratory parameters.
Topics: Acid-Base Equilibrium; Acidosis; Adolescent; Child; Child, Preschool; Female; Ghana; Humans; Infant; | 2005 |
Lactate levels in severe malarial anaemia are associated with haemozoin-containing neutrophils and low levels of IL-12.
Topics: Anemia; Child, Preschool; Female; Hemeproteins; Humans; Infant; Interleukin-12; Kenya; Lactic Acid; | 2006 |
Glycerol metabolism in severe falciparum malaria.
Topics: Adolescent; Adult; Blood Glucose; Female; Galactose; Glycerol; Humans; Indocyanine Green; Kinetics; | 1994 |
[Prognostic value of lactate determination in cerebral malaria in the Cameroonian child].
Topics: Adolescent; Cameroon; Child; Child, Preschool; Female; Humans; Infant; Insulin; Lactates; Lactic Aci | 1995 |
High-dose adrenaline with low systemic vascular resistance and symmetrical peripheral gangrene.
Topics: Adult; Cardiac Output; Epinephrine; Gangrene; Humans; Hypotension; Lactic Acid; Malaria, Falciparum; | 1996 |
Glucose homeostasis in children with falciparum malaria: precursor supply limits gluconeogenesis and glucose production.
Topics: Alanine; Blood Glucose; Child; Child, Preschool; Cytokines; Deuterium; Female; Gluconeogenesis; Gluc | 1997 |
Acidosis in severe childhood malaria.
Topics: Acidosis; Age Factors; Child, Preschool; Coma; Female; Hemoglobins; Humans; Infant; Lactic Acid; Mal | 1997 |
The pathophysiologic and prognostic significance of acidosis in severe adult malaria.
Topics: Acidosis; Adolescent; Adult; Aged; Cohort Studies; Female; Hepatic Veins; Humans; Lactic Acid; Malar | 2000 |
Transport of lactate and pyruvate in the intraerythrocytic malaria parasite, Plasmodium falciparum.
Topics: Animals; Anion Transport Proteins; Biological Transport; Carrier Proteins; Erythrocytes; Glycolysis; | 2001 |
Remarkably high antibody levels and protection against P. falciparum malaria in Aotus monkeys after a single immunisation of SPf66 encapsulated in PLGA microspheres.
Topics: Alum Compounds; Animals; Antibodies, Protozoan; Antigens, Protozoan; Aotus trivirgatus; Biocompatibl | 2002 |
Hepatic blood flow and metabolism in severe falciparum malaria: clearance of intravenously administered galactose.
Topics: Acute Disease; Adolescent; Adult; Animals; Blood Glucose; Female; Galactose; Humans; Lactates; Lacti | 1992 |