lactic acid has been researched along with MODS in 123 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We describe a rare case of multiple organ failure due to intravascular lymphoma with severe lactic acidosis in a patient who survived." | 7.96 | Successful Intensive Care Treatment of Severe Lactic Acidosis and Tumor Lysis Syndrome Related to Intravascular Lymphoma. ( Genda, Y; Ichiba, S; Mase, H; Ogawa, Y; Sakamoto, A; Takeuchi, J, 2020) |
| "Therapeutic effects of continuous intravenous infusions of solvent-free low doses of resveratrol on organ injury and systemic consequences resulting from severe hemorrhagic shock in rats were studied." | 7.85 | Attenuation of Multiple Organ Damage by Continuous Low-Dose Solvent-Free Infusions of Resveratrol after Severe Hemorrhagic Shock in Rats. ( Kirsch, M; Müller, T; Petrat, F, 2017) |
| "A 16-year-old perioperative paediatric patient presented with refractory lactic acidosis and multiorgan failure due to thiamine-deficient total parenteral nutrition during a recent national multivitamin shortage." | 7.80 | Severe lactic acidosis and multiorgan failure due to thiamine deficiency during total parenteral nutrition. ( Hartman, G; Mowbray, C; Pageler, N; Ramsi, M, 2014) |
| "One hundred and one consecutive patients with acetaminophen-induced fulminant hepatic failure and grade 3-4 hepatic encephalopathy." | 7.73 | Prognostic implications of hyperlactatemia, multiple organ failure, and systemic inflammatory response syndrome in patients with acetaminophen-induced acute liver failure. ( Larsen, FS; Schmidt, LE, 2006) |
| "To explore the effect of total parenteral nutrition (TPN) supplemented with glutamine on the activity of plasma diamine oxidase (DAO) and D-lactate content in blood of patients with multiple organ dysfunction syndrome (MODS)." | 5.12 | [Effect of total parenteral nutrition with supplementation of glutamine on the plasma diamine oxidase activity and D-lactate content in patients with multiple organ dysfunction syndrome]. ( Tian, H; Wang, KF; Wu, TJ, 2006) |
| "To determine the effects on hemodynamics, laboratory parameters, and renal function of terlipressin used in septic-shock patients with hypotension not responsive to high-dose norepinephrine (>2." | 5.11 | Terlipressin in catecholamine-resistant septic shock patients. ( Albanèse, J; Chaabane, W; Delmas, A; Garnier, F; Leone, M; Martin, C, 2004) |
| " As S-adenosylhomocysteine (SAH) was shown to reflect tissue hypoxia, we compared the ability of SAH versus lactate to predict the progression of inflammatory and septic disease to septic organ dysfunction and death." | 4.31 | S-Adenosylhomocysteine Is a Useful Metabolic Factor in the Early Prediction of Septic Disease Progression and Death in Critically Ill Patients: A Prospective Cohort Study. ( Brohm, K; Centner, FS; Fuderer, T; Hahn, B; Jäger, E; Krebs, J; Lindner, HA; Mindt, S; Neumaier, M; Schneider-Lindner, V; Schoettler, JJ; Thiel, M, 2023) |
| " We describe a rare case of multiple organ failure due to intravascular lymphoma with severe lactic acidosis in a patient who survived." | 3.96 | Successful Intensive Care Treatment of Severe Lactic Acidosis and Tumor Lysis Syndrome Related to Intravascular Lymphoma. ( Genda, Y; Ichiba, S; Mase, H; Ogawa, Y; Sakamoto, A; Takeuchi, J, 2020) |
| "Therapeutic effects of continuous intravenous infusions of solvent-free low doses of resveratrol on organ injury and systemic consequences resulting from severe hemorrhagic shock in rats were studied." | 3.85 | Attenuation of Multiple Organ Damage by Continuous Low-Dose Solvent-Free Infusions of Resveratrol after Severe Hemorrhagic Shock in Rats. ( Kirsch, M; Müller, T; Petrat, F, 2017) |
| " High lactic acid levels at 24 hours after ECMO, MODS and gastrointestinal bleeding are predictors of in-hospital mortality in adult patients, and appropriate control of blood sugar was beneficial for the recovery of patients." | 3.81 | [Outcome of extracorporeal membrane oxygenation support for adult patients in Fuwai Hospital during the last 10 years: treatment strategy and risk factors]. ( Bingyan, J; Cun, L; Feilong, H; Guodong, G; Jinxiao, H; Kun, Y; Lin, L; Qiang, H, 2015) |
| "This study examined the effects of polyethylene oxide (PEO) on the survival rate, hemodynamics, blood gas indexes, lactic acid levels, microcirculation, and inflammatory cytokine levels in rats subjected to severe hemorrhagic shock." | 3.81 | Protective effects of polyethylene oxide on the vascular and organ function of rats with severe hemorrhagic shock. ( Dong, Z; Huang, T; Li, Q, 2015) |
| "A 16-year-old perioperative paediatric patient presented with refractory lactic acidosis and multiorgan failure due to thiamine-deficient total parenteral nutrition during a recent national multivitamin shortage." | 3.80 | Severe lactic acidosis and multiorgan failure due to thiamine deficiency during total parenteral nutrition. ( Hartman, G; Mowbray, C; Pageler, N; Ramsi, M, 2014) |
| " DIC patients showed higher Sequential Organ Failure Assessment (SOFA) scores, the prevalence of multiple organ dysfunction syndrome (MODS) and more increased soluble fibrin and lactate levels." | 3.79 | The dynamics of angiogenic factors and their soluble receptors in relation to organ dysfunction in disseminated intravascular coagulation associated with sepsis. ( Gando, S; Jesmin, S; Sultana, SS; Wada, T; Zaedi, S, 2013) |
| "One hundred and one consecutive patients with acetaminophen-induced fulminant hepatic failure and grade 3-4 hepatic encephalopathy." | 3.73 | Prognostic implications of hyperlactatemia, multiple organ failure, and systemic inflammatory response syndrome in patients with acetaminophen-induced acute liver failure. ( Larsen, FS; Schmidt, LE, 2006) |
| "Initial lactic acidosis is associated with lower cardiac performance and higher morbidity and mortality." | 3.70 | The golden hour and the silver day: detection and correction of occult hypoperfusion within 24 hours improves outcome from major trauma. ( Blow, O; Butler, K; Claridge, JA; Magliore, L; Young, JS, 1999) |
| " Hyperlactatemia with L/P ratio elevation and lactic acidosis is likely to be associated with inadequate tissue perfusion." | 3.70 | Time-pattern of lactate and lactate to pyruvate ratio in the first 24 hours of intensive care emergency admissions. ( Kari, A; Ruokonen, E; Suistomaa, M; Takala, J, 2000) |
| " In addition, all tyrphostins and genistein attenuated the liver injury/failure, the pancreatic injury, the hypoglycaemia and the lactic acidosis caused by LPS." | 3.69 | Effects of tyrphostins and genistein on the circulatory failure and organ dysfunction caused by endotoxin in the rat: a possible role for protein tyrosine kinase. ( Ruetten, H; Thiemermann, C, 1997) |
| " Despite this there is still controversy about the most appropriate therapy of lactic acidosis, and the relationship of commonly used acid base measurements to blood lactate levels." | 3.68 | Lactate and acid base changes in the critically ill. ( Grant, IS; Mackenzie, SJ; Nimmo, GR, 1991) |
| "Adult patients with severe sepsis and systolic blood pressure less than 90 mm Hg despite intravascular volume expansion and/or serum lactate greater than or equal to 4." | 2.79 | Randomized controlled trial of inhaled nitric oxide for the treatment of microcirculatory dysfunction in patients with sepsis*. ( Anderson, K; Chansky, ME; Dellinger, RP; Dezfulian, C; Durflinger, P; Glaspey, LJ; Hollenberg, SM; Parrillo, JE; Roberts, BW; Trzeciak, S, 2014) |
| "Eighty-nine patients with refractory septic shock and MODS undergoing HVHF, fluid resuscitation were included in the trial, and they were randomly divided into fluid resuscitation group (group A, 41 cases) and HVHF and fluid resuscitation group (group B, 48 cases)." | 2.74 | [Study the effects of high-volume hemofiltration and fluid resuscitation on removing blood lactic acid and pro-inflammatory cytokines in patients with refractory septic shock]. ( Chu, YF; Ding, M; Jiang, JJ; Meng, M; Ren, HS; Wang, CT; Yu, JB; Zhang, JC, 2009) |
| "Eight patients with multiple organ dysfunction syndrome (MODS) requiring CVVHDF." | 2.71 | Effect of bicarbonate and lactate buffer on glucose and lactate metabolism during hemodiafiltration in patients with multiple organ failure. ( Berger, MM; Bollmann, MD; Cayeux, MC; Chioléro, RL; Martinez, A; Revelly, JP; Schaller, MD; Tappy, L, 2004) |
| "A convenience cohort of patients with severe sepsis or septic shock." | 2.71 | Early lactate clearance is associated with improved outcome in severe sepsis and septic shock. ( Jacobsen, G; Knoblich, BP; Muzzin, A; Nguyen, HB; Ressler, JA; Rivers, EP; Tomlanovich, MC, 2004) |
| "Both causes of septic shock are associated with an extremely high severity of illness (Acute Physiology and Chronic Health Evaluation II: candidemic septic shock, 32 +/- 10; bacteremic septic shock, 30 +/- 8; p =." | 2.70 | Candidemia as a cause of septic shock and multiple organ failure in nonimmunocompromised patients. ( Hadley, S; Lee, WW; Nasraway, SA; Ruthazer, R, 2002) |
| "Sepsis was identified as Gram-positive in 49 patients, Gram-negative in 40, mixed in 37, and unknown in 26." | 2.69 | Phase II multicenter clinical study of the platelet-activating factor receptor antagonist BB-882 in the treatment of sepsis. ( Bakker, J; Curtis, L; Spapen, H; Vincent, JL; Webster, NR, 2000) |
| "Cardiogenic shock is difficult to diagnose due to diverse presentations, overlap with other shock states (i." | 2.66 | Identifying cardiogenic shock in the emergency department. ( Daly, M; Koyfman, A; Lentz, S; Long, B, 2020) |
| "In the developed countries septic shock has a favorable outcome for the majority of previously healthy children but also in children with comorbidities if all available medical resources were used." | 2.49 | Early recognition of septic shock in children. ( Dohna-Schwake, C; Felderhoff-Müser, U, 2013) |
| "After severe multiple injuries (first hit) a two-phase immunological response with early hyperinflammation followed by immunosuppression can be observed." | 2.49 | [Pathophysiology of multiple trauma : intensive care medicine and timing of treatment]. ( Lehnert, M; Lustenberger, T; Marzi, I; Relja, B; Wutzler, S, 2013) |
| "The prognosis of cardiogenic shock is still dismal despite advancements in diagnostic and therapeutic options." | 2.46 | [Evaluation of microcirculation in cardiogenic shock]. ( Ferrari, M; Figulla, HR; Fritzenwanger, M; Jung, C; Lauten, A, 2010) |
| "Patients with sepsis-induced multiple organ failure often experience muscle fatigue in both locomotive and respiratory muscles." | 2.44 | Mitochondrial function in sepsis: respiratory versus leg muscle. ( Fredriksson, K; Rooyackers, O, 2007) |
| "Sepsis and multiple organ failure are characterized by an excessive release of inflammatory mediators and a marked stimulation of stress hormones." | 2.44 | Substrate utilization in sepsis and multiple organ failure. ( Chioléro, R; Tappy, L, 2007) |
| "Moderate to severe neonatal encephalopathy in asphyxiated term infants is associated with a high risk of cerebral palsy (especially quadriplegic or dyskinetic type) and/or cognitive disorders." | 2.44 | [Definition of intrapartum asphyxia and effects on outcome]. ( Zupan Simunek, V, 2008) |
| "LAR measured early in the course of critical illness is significantly associated with mortality and development of MODS when compared with initial lactate or initial albumin alone in critically ill pediatric patients." | 1.91 | The Association of the Lactate-Albumin Ratio With Mortality and Multiple Organ Dysfunction in PICU Patients. ( Gai, J; Patel, AK; Pollack, MM; Ray, CC, 2023) |
| "Validation of the host-mRNA infection severity classifier IMX-SEV-2." | 1.72 | Prospective validation of a transcriptomic severity classifier among patients with suspected acute infection and sepsis in the emergency department. ( Bauer, W; Bergström, WH; Buturovic, L; Diehl-Wiesenecker, E; Galtung, N; Kappert, K; Lehmann, D; Liesenfeld, O; Luethy, R; Markmann, N; Mayhew, M; Somasundaram, R; Sweeney, TE; Tauber, R; Wacker, J, 2022) |
| "Severe Acidosis was present in 35." | 1.72 | Laboratory Markers of Acidosis and Mortality in Cardiogenic Shock: Developing a Definition of Hemometabolic Shock. ( Baran, DA; Barsness, GW; Henry, TD; Jentzer, JC; Kashani, KB; Patel, PC; Van Diepen, S; Wiley, BM, 2022) |
| "Sepsis is a host response with life-threatening organ dysfunction caused by an infection." | 1.72 | Risk stratification and prognostic value of serum neutrophil gelatinase-associated lipocalin (sNGAL) in sepsis patients. ( Fan, J; He, ZM; Sun, Y; Wu, Y; Yu, C; Zhang, W; Zhou, Y, 2022) |
| "The incidence of nonocclusive mesenteric ischemia was particularly high." | 1.51 | Prognostic factors of acute mesenteric ischemia in ICU patients. ( Caluwaerts, M; Castanares-Zapatero, D; Hantson, P; Laterre, PF, 2019) |
| "Early hyperglycemia is associated with multiple organ failure (MOF) after traumatic injury; however, few studies have considered the contribution of depth of clinical shock." | 1.48 | Does Lactate Affect the Association of Early Hyperglycemia and Multiple Organ Failure in Severely Injured Blunt Trauma Patients? ( Galvagno, SM; Mazzeffi, MA; Richards, JE; Rock, P; Scalea, TM, 2018) |
| "Out of 410 severe sepsis admissions, 20 patients experienced early death." | 1.46 | Clinical predictors of early death from sepsis. ( Bowman, J; Guirgis, FW; Javed, A; Jones, AE; Puskarich, MA; Robinson, T; Sterling, SA, 2017) |
| "Two hundred sixty patients with severe sepsis or septic shock were included." | 1.42 | Long-Term β-Blocker Therapy Decreases Blood Lactate Concentration in Severely Septic Patients. ( Contenti, J; Corraze, H; Lemoël, F; Levraut, J; Occelli, C, 2015) |
| "A total of 80 cases of severe sepsis patients with MODS treated at our center from 2011 January to 2013 October were selected and assigned to receive CHVHF (n = 42) and continuous volume hemofiltration (CVHF, n = 38)." | 1.42 | [Efficacies of continuous high volume hemofiltration in severe sepsis patients with multiple organ dysfunction syndrome]. ( Cai, H; Du, C; Shao, S; Yan, Q, 2015) |
| "85 patients with a new septic shock episode were included." | 1.39 | Persistently high venous-to-arterial carbon dioxide differences during early resuscitation are associated with poor outcomes in septic shock. ( Arango-Dávila, C; Bautista-Rincón, DF; Bermúdez, W; García, AF; Granados, M; Gutiérrez, A; Hernández, G; Ospina-Tascón, GA; Tafur, JD; Umaña, M, 2013) |
| "Acetaminophen-induced acute liver failure (ALF) is a complex multiorgan illness." | 1.38 | Comparison of the sequential organ failure assessment score with the King's College Hospital criteria and the model for end-stage liver disease score for the prognosis of acetaminophen-induced acute liver failure. ( Agarwal, B; Betrosian, A; Burroughs, AK; Cholongitas, E; O'Beirne, J; Patch, D; Shaw, S; Theocharidou, E; Vasianopoulou, P, 2012) |
| "The lactic acid was measured at the beginning and at 24 hours of the trauma and associating it with the patient morbidity and mortality." | 1.38 | [Measurement of lactic acid in multiple injury patients and its usefulness as a predictor of multiorgan failure and mortality]. ( Gómez Díaz, C; Llaquet Bayo, H; Luna Aufroy, A; Montmany Vioque, S; Navarro Soto, S; Rebasa Cladera, P, 2012) |
| "Two hundred sixteen patients with severe sepsis arrived by EMS." | 1.36 | Out-of-hospital characteristics and care of patients with severe sepsis: a cohort study. ( Band, RA; Cooke, CR; Gaieski, DF; Goss, CH; Hylton, J; Mikkelsen, ME; Rea, TD; Seymour, CW, 2010) |
| "Sepsis is a major clinical challenge that is associated with encephalopathy and multi-organ dysfunction." | 1.34 | Caecal ligation and puncture in the rat mimics the pathophysiological changes in human sepsis and causes multi-organ dysfunction. ( Andrews, PL; Brooks, HF; Davies, DC; Moss, RF; Osabutey, CK, 2007) |
| "Critically ill patients treated for multiple organ failure often develop muscle dysfunction." | 1.33 | Derangements in mitochondrial metabolism in intercostal and leg muscle of critically ill patients with sepsis-induced multiple organ failure. ( Fredriksson, K; Hammarqvist, F; Hultenby, K; Ljungqvist, O; Rooyackers, O; Strigård, K; Wernerman, J, 2006) |
| "However, the duration of septic shock (median, 42 h [interquartile range, 21 to 97 h] vs median, 93 h [interquartile range, 32 to 241 h], p = 0." | 1.32 | Septic shock of early or late onset: does it matter? ( De Backer, D; Melot, C; Orellana-Jimenez, CE; Roman-Marchant, O; Vincent, JL, 2004) |
| "Fifty-six patients with severe sepsis and blood lactate concentration <3 mmol/L." | 1.32 | Low exogenous lactate clearance as an early predictor of mortality in normolactatemic critically ill septic patients. ( Ciebiera, JP; Grimaud, D; Ichai, C; Levraut, J; Perus, O; Petit, I, 2003) |
| "Ischemic colitis is a severe complication of aortic surgery." | 1.31 | [Utility of sigmoid intramucosal pH in the early diagnosis of ischemic colitis after aorta surgery]. ( Fernández-Quero Bonilla, L; Ferrando Jordá, A; Garutti Martínez, I; López Saña, J; Portas González, M, 2002) |
| "Thyroid storm is a rare disorder characterized by hypertension, hyperthermia, and multiple systems involvement." | 1.31 | Thyroid storm presenting as multiple organ dysfunction syndrome. ( Bartelloni, P; Hutchinson, KA; Jiang, YZ; Manthous, CA, 2000) |
| "The purpose of this study was to determine the physiologic variables that predict major adverse events in children in the intensive care unit after cardiac operations." | 1.30 | Early markers of major adverse events in children after cardiac operations. ( Butt, W; Duke, T; Karl, TR; South, M, 1997) |
| "In trauma patients, hypothermia is a frequent event." | 1.30 | Adenosine-triphosphate in trauma-related and elective hypothermia. ( Hildebrandt, F; Seekamp, A; Tscherne, H; van Griensven, M; Wahlers, T, 1999) |
| "In 87 patients with a first episode of septic shock, we measured initial lactate (at onset of septic shock), final lactate (before recovery or death), "lactime" (time during which blood lactate was > 2." | 1.29 | Serial blood lactate levels can predict the development of multiple organ failure following septic shock. ( Bakker, J; Coffernils, M; Gris, P; Kahn, RJ; Vincent, JL, 1996) |
| "Shock is defined as the summation of cellular dysfunction and resultant impairment of the function in various organs." | 1.28 | [Cellular metabolic consideration in the pathophysiology and the treatment of shock]. ( Hirasawa, H; Oda, S; Otake, Y; Shiga, H; Sugai, T, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.81) | 18.7374 |
| 1990's | 23 (18.70) | 18.2507 |
| 2000's | 40 (32.52) | 29.6817 |
| 2010's | 44 (35.77) | 24.3611 |
| 2020's | 15 (12.20) | 2.80 |
| Authors | Studies |
|---|---|
| Wu, Y | 2 |
| Yu, C | 1 |
| Zhou, Y | 1 |
| He, ZM | 1 |
| Zhang, W | 1 |
| Fan, J | 1 |
| Sun, Y | 1 |
| Mc Dermott, S | 1 |
| Dargan, C | 1 |
| Gonzalez Dominguez, E | 1 |
| Music Aplenc, L | 1 |
| Flatt, T | 1 |
| Iqbal, N | 1 |
| Galtung, N | 1 |
| Diehl-Wiesenecker, E | 1 |
| Lehmann, D | 1 |
| Markmann, N | 1 |
| Bergström, WH | 1 |
| Wacker, J | 1 |
| Liesenfeld, O | 1 |
| Mayhew, M | 1 |
| Buturovic, L | 1 |
| Luethy, R | 1 |
| Sweeney, TE | 1 |
| Tauber, R | 1 |
| Kappert, K | 1 |
| Somasundaram, R | 1 |
| Bauer, W | 1 |
| Ray, CC | 1 |
| Pollack, MM | 1 |
| Gai, J | 1 |
| Patel, AK | 1 |
| Centner, FS | 1 |
| Schoettler, JJ | 1 |
| Brohm, K | 1 |
| Mindt, S | 1 |
| Jäger, E | 1 |
| Hahn, B | 1 |
| Fuderer, T | 1 |
| Lindner, HA | 1 |
| Schneider-Lindner, V | 1 |
| Krebs, J | 1 |
| Neumaier, M | 1 |
| Thiel, M | 1 |
| Butt, W | 2 |
| Ogura, A | 1 |
| Tsurumi, A | 1 |
| Que, YA | 1 |
| Almpani, M | 1 |
| Zheng, H | 1 |
| Tompkins, RG | 1 |
| Ryan, CM | 1 |
| Rahme, LG | 1 |
| Weiss, SL | 1 |
| Peters, MJ | 1 |
| Alhazzani, W | 1 |
| Agus, MSD | 1 |
| Flori, HR | 1 |
| Inwald, DP | 1 |
| Nadel, S | 1 |
| Schlapbach, LJ | 1 |
| Tasker, RC | 1 |
| Argent, AC | 1 |
| Brierley, J | 1 |
| Carcillo, J | 1 |
| Carrol, ED | 1 |
| Carroll, CL | 1 |
| Cheifetz, IM | 1 |
| Choong, K | 1 |
| Cies, JJ | 1 |
| Cruz, AT | 1 |
| De Luca, D | 1 |
| Deep, A | 1 |
| Faust, SN | 1 |
| De Oliveira, CF | 1 |
| Hall, MW | 1 |
| Ishimine, P | 1 |
| Javouhey, E | 1 |
| Joosten, KFM | 1 |
| Joshi, P | 2 |
| Karam, O | 1 |
| Kneyber, MCJ | 1 |
| Lemson, J | 1 |
| MacLaren, G | 1 |
| Mehta, NM | 1 |
| Møller, MH | 1 |
| Newth, CJL | 1 |
| Nguyen, TC | 1 |
| Nishisaki, A | 1 |
| Nunnally, ME | 1 |
| Parker, MM | 1 |
| Paul, RM | 1 |
| Randolph, AG | 1 |
| Ranjit, S | 1 |
| Romer, LH | 1 |
| Scott, HF | 2 |
| Tume, LN | 1 |
| Verger, JT | 1 |
| Williams, EA | 1 |
| Wolf, J | 1 |
| Wong, HR | 1 |
| Zimmerman, JJ | 1 |
| Kissoon, N | 1 |
| Tissieres, P | 1 |
| El-Mekkawy, MS | 1 |
| Ellahony, DM | 1 |
| Khalifa, KAE | 1 |
| Abd Elsattar, ES | 1 |
| Shu, W | 1 |
| Wan, J | 1 |
| Chen, J | 2 |
| He, W | 1 |
| Zhu, Y | 3 |
| Zeng, H | 1 |
| Liu, P | 1 |
| Xia, L | 1 |
| Lu, N | 1 |
| Chen, W | 1 |
| You, J | 1 |
| Daly, M | 1 |
| Long, B | 1 |
| Koyfman, A | 1 |
| Lentz, S | 1 |
| Jentzer, JC | 1 |
| Kashani, KB | 1 |
| Wiley, BM | 1 |
| Patel, PC | 1 |
| Baran, DA | 1 |
| Barsness, GW | 1 |
| Henry, TD | 1 |
| Van Diepen, S | 1 |
| Wang, J | 1 |
| Applefeld, WN | 1 |
| Sun, J | 1 |
| Solomon, SB | 1 |
| Feng, J | 1 |
| Couse, ZG | 1 |
| Risoleo, TF | 1 |
| Danner, RL | 1 |
| Tejero, J | 1 |
| Lertora, J | 1 |
| Alipour, E | 1 |
| Basu, S | 1 |
| Sachdev, V | 1 |
| Kim-Shapiro, DB | 1 |
| Gladwin, MT | 1 |
| Klein, HG | 1 |
| Natanson, C | 1 |
| Javed, A | 1 |
| Guirgis, FW | 1 |
| Sterling, SA | 1 |
| Puskarich, MA | 2 |
| Bowman, J | 1 |
| Robinson, T | 1 |
| Jones, AE | 2 |
| Müller, T | 1 |
| Kirsch, M | 1 |
| Petrat, F | 1 |
| Michard, B | 1 |
| Artzner, T | 1 |
| Lebas, B | 1 |
| Besch, C | 1 |
| Guillot, M | 1 |
| Faitot, F | 1 |
| Lefebvre, F | 1 |
| Bachellier, P | 1 |
| Castelain, V | 1 |
| Maestraggi, Q | 1 |
| Schneider, F | 1 |
| Xu, P | 1 |
| Wang, F | 1 |
| Zhou, XL | 1 |
| Li, L | 2 |
| Xiong, D | 1 |
| Yong, YQ | 1 |
| Zhao, Y | 1 |
| Jiang, WX | 1 |
| Shetty, A | 1 |
| MacDonald, SP | 1 |
| Williams, JM | 1 |
| van Bockxmeer, J | 1 |
| de Groot, B | 1 |
| Esteve Cuevas, LM | 1 |
| Ansems, A | 1 |
| Green, M | 1 |
| Thompson, K | 1 |
| Lander, H | 1 |
| Greenslade, J | 1 |
| Finfer, S | 1 |
| Iredell, J | 1 |
| Richards, JE | 1 |
| Scalea, TM | 2 |
| Mazzeffi, MA | 1 |
| Rock, P | 1 |
| Galvagno, SM | 1 |
| Gómez-Ramos, JJ | 1 |
| Marín-Medina, A | 1 |
| Prieto-Miranda, SE | 1 |
| Dávalos-Rodríguez, IP | 1 |
| Alatorre-Jiménez, MA | 1 |
| Esteban-Zubero, E | 1 |
| Bellomy, ML | 1 |
| Freundlich, RE | 1 |
| Short, JH | 1 |
| Sen, A | 1 |
| Ariza-Solé, A | 1 |
| Sánchez-Salado, JC | 1 |
| Sbraga, F | 1 |
| Ortiz, D | 1 |
| González-Costello, J | 1 |
| Blasco-Lucas, A | 1 |
| Alegre, O | 1 |
| Toral, D | 1 |
| Lorente, V | 1 |
| Santafosta, E | 1 |
| Toscano, J | 1 |
| Izquierdo, A | 1 |
| Miralles, A | 1 |
| Cequier, Á | 1 |
| Caluwaerts, M | 1 |
| Castanares-Zapatero, D | 1 |
| Laterre, PF | 1 |
| Hantson, P | 1 |
| Mase, H | 1 |
| Ogawa, Y | 1 |
| Takeuchi, J | 1 |
| Genda, Y | 1 |
| Ichiba, S | 1 |
| Sakamoto, A | 1 |
| Dohna-Schwake, C | 1 |
| Felderhoff-Müser, U | 1 |
| Wutzler, S | 1 |
| Lustenberger, T | 1 |
| Relja, B | 1 |
| Lehnert, M | 1 |
| Marzi, I | 1 |
| Dabrowski, W | 1 |
| Kocki, T | 1 |
| Pilat, J | 1 |
| Parada-Turska, J | 1 |
| Malbrain, ML | 1 |
| Lorente, L | 1 |
| Martín, MM | 1 |
| Abreu-González, P | 1 |
| Domínguez-Rodriguez, A | 1 |
| Labarta, L | 1 |
| Díaz, C | 1 |
| Solé-Violán, J | 1 |
| Ferreres, J | 1 |
| Cabrera, J | 1 |
| Igeño, JC | 1 |
| Jiménez, A | 1 |
| Ospina-Tascón, GA | 1 |
| Bautista-Rincón, DF | 1 |
| Umaña, M | 1 |
| Tafur, JD | 1 |
| Gutiérrez, A | 1 |
| García, AF | 1 |
| Bermúdez, W | 1 |
| Granados, M | 1 |
| Arango-Dávila, C | 1 |
| Hernández, G | 1 |
| Ramsi, M | 1 |
| Mowbray, C | 1 |
| Hartman, G | 1 |
| Pageler, N | 1 |
| Trzeciak, S | 1 |
| Glaspey, LJ | 1 |
| Dellinger, RP | 1 |
| Durflinger, P | 1 |
| Anderson, K | 1 |
| Dezfulian, C | 1 |
| Roberts, BW | 1 |
| Chansky, ME | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Sepsis Prognosis and Diagnosis in the Emergency Department Using a Host Response Classifier (SPEED) UK - a Multi-Centre Observational Study[NCT05639504] | 0 participants (Actual) | Observational | 2022-12-31 | Withdrawn (stopped due to Study never started, change in company focus on US) | |||
| Septic Shock Management Guided by Ultrasound: A Randomized Control Trial (SEPTICUS Trial)[NCT04728529] | 340 participants (Anticipated) | Interventional | 2021-09-02 | Recruiting | |||
| Randomized Controlled Trial of Dopamine, Adrenaline, and Blood Transfusion for Treatment of Fluid Refractory Shock in Children With Severe Acute Malnutrition or Severe Underweight and Cholera or Other Dehydrating Diarrheas[NCT04750070] | Phase 3 | 135 participants (Anticipated) | Interventional | 2021-08-17 | Recruiting | ||
| Reducing Empiric VAncomycin Use in Pediatric Suspected Sepsis (REVAMP-Sepsis)[NCT05975671] | 52,500 participants (Anticipated) | Interventional | 2023-08-21 | Recruiting | |||
| Oxygen for Category II Intrauterine Fetal Resuscitation: A Randomized, Noninferiority Trial[NCT02741284] | 114 participants (Actual) | Interventional | 2016-06-30 | Completed | |||
| Capillary Refill Time Response to a Rapid Fluid Challenge in Septic Shock Patients: Pathophysiological Determinants, and Relation to Changes in Systemic, Regional and Microcirculatory Blood Flow[NCT04693923] | 42 participants (Anticipated) | Interventional | 2021-02-01 | Not yet recruiting | |||
| Peripheral Perfusion Versus Lactate Targeted Fluid Resuscitation in Septic Shock: ANDROMEDA-SHOCK PHYSIOLOGY STUDY[NCT03762005] | 46 participants (Anticipated) | Interventional | 2018-06-01 | Recruiting | |||
| Early Goal Directed Therapy Using a Physiological Holistic View. A Multicenter Study in Latin America: The ANDROMEDA-SHOCK Study[NCT03078712] | 424 participants (Actual) | Interventional | 2017-03-01 | Completed | |||
| Randomized Double-blind Placebo-controlled Trial of Inhaled Nitric Oxide for the Treatment of Microcirculatory Dysfunction and Organ Failure in Sepsis[NCT00608322] | Phase 3 | 49 participants (Actual) | Interventional | 2009-08-31 | Completed | ||
| Mortality Due to Septic Shock Associated With Thrombocytopenia in the Intensive Care Unit[NCT03617965] | 350 participants (Anticipated) | Observational | 2018-08-15 | Active, not recruiting | |||
| A Phase II Double Blind Randomized Controlled Trial of High Dose Vitamin B12 in Septic Shock[NCT03783091] | Phase 2 | 20 participants (Anticipated) | Interventional | 2019-08-05 | Recruiting | ||
| Characteristics of Patients With Severe Dengue Admitted in Critical Care Units at Villavicencio, Colombia. A Retrospective Observational Trial.[NCT05938647] | 50 participants (Anticipated) | Observational | 2023-07-01 | Recruiting | |||
| Markers of Tissue Perfusion as Predictors of Complicated Evolution in Patients With Left Ventricular Dysfunction Submitted to Coronary Artery Bypass Surgery[NCT01178866] | 87 participants (Actual) | Observational | 2006-01-31 | Completed | |||
| Fluid Resuscitation Optimization in Surgical Trauma Patients (FROST)[NCT02742974] | 196 participants (Anticipated) | Interventional | 2015-12-31 | Recruiting | |||
| The Thiamine Administration After Cardiac Surgery Trial[NCT04641104] | Phase 4 | 200 participants (Actual) | Interventional | 2020-11-20 | Completed | ||
| Emergency Department (ED) Flow-directed Fluid Optimization Resuscitation Trial (EFFORT)[NCT01128413] | 22 participants (Actual) | Interventional | 2010-07-31 | Terminated (stopped due to lack of resources) | |||
| Lactate Clearance and Mortality in Patients With Severe Sepsis and Septic Shock: Comparison by Hepatic Dysfunction[NCT01709565] | 245 participants (Anticipated) | Observational | 2012-07-31 | Recruiting | |||
| Evaluation of Hepatic Mitochondrial Function in Sepsis[NCT00889083] | 0 participants (Actual) | Observational | 2009-04-30 | Withdrawn (stopped due to no patients to include) | |||
| Modulation of Systemic Inflammatory Response in Critically Ill Children After Glutamine Supplementation[NCT01367223] | Phase 4 | 101 participants (Actual) | Interventional | 2010-04-30 | Completed | ||
| Sodium Bicarbonate to Treat Severe Acidosis in the Critically Ill : A Multiple Center Randomized Clinical Trial (BICAR-ICU)[NCT02476253] | Phase 3 | 400 participants (Anticipated) | Interventional | 2015-05-05 | Recruiting | ||
| Analysis of Lactate Monitoring Requirement in Emergent Surgical Interventions in Noncritical Traumatic Long Bone Fractures[NCT05611398] | 164 participants (Actual) | Observational | 2021-01-01 | Completed | |||
| Early Lactate-Directed Therapy on the ICU: A Randomized Controlled Trial[NCT00270673] | Phase 3 | 350 participants (Anticipated) | Interventional | 2006-02-28 | Completed | ||
| Strong Ion Gap as Prognostic Indicator for Adult Patients Admitted With Shock to the Intensive Care Units[NCT02652364] | 112 participants (Actual) | Observational | 2015-10-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Determined by umbilical artery cord gas collected at time of delivery and only in patients with paired (umbilical artery and umbilical vein) cord gases. (NCT02741284)
Timeframe: At delivery
| Intervention | mmol/L (Mean) |
|---|---|
| Room Air | 3.5 |
| Oxygen | 3.4 |
Number of patients with resolution of recurrent variable or recurrent late decelerations within 60 minutes of randomization (NCT02741284)
Timeframe: 60 minutes after randomization
| Intervention | Participants (Count of Participants) |
|---|---|
| No Oxygen | 49 |
| Oxygen | 43 |
As determined by cord gas collection at time of delivery (NCT02741284)
Timeframe: At time of delivery
| Intervention | meq/L (Mean) |
|---|---|
| Room Air | -3.6 |
| Oxygen | -3.6 |
Partial pressure of carbon dioxide as collected on cord gases at time of delivery (NCT02741284)
Timeframe: At time of delivery
| Intervention | mmHg (Mean) |
|---|---|
| Room Air | 55.9 |
| Oxygen | 57.4 |
Determined by umbilical artery cord gas collected at time of delivery and only in patients with paired (umbilical artery and umbilical vein) cord gases. (NCT02741284)
Timeframe: At time of delivery
| Intervention | pH units (Mean) |
|---|---|
| Room Air | 7.26 |
| Oxygen | 7.25 |
Partial pressure of oxygen as collected on cord gases at time of delivery (NCT02741284)
Timeframe: Time of delivery
| Intervention | mm Hg (Mean) |
|---|---|
| Room Air | 19.7 |
| Oxygen | 24.4 |
Delivery via Cesarean section, operative vaginal delivery (forceps or vacuum), or spontaneous vaginal delivery (NCT02741284)
Timeframe: At delivery
| Intervention | Participants (Count of Participants) | |||
|---|---|---|---|---|
| Cesarean delivery | Cesarean delivery for non reassuring fetal status | Operative vaginal delivery | Spontaenous vaginal delivery | |
| Oxygen | 6 | 2 | 1 | 41 |
| Room Air | 2 | 0 | 6 | 43 |
The MFI is a continuous scale from 0-3, with 3.0 being better outcome and 0.0 being worse outcome. (NCT00608322)
Timeframe: 0-2 hours of study drug administration
| Intervention | units on a scale (Median) |
|---|---|
| Inhaled Nitric Oxide | -0.06 |
| Sham (Comparator) | -0.03 |
The median lactate clearance from time zero to within 6 hours of the ED stay. (NCT01128413)
Timeframe: The median lactate clearance within 6 hours of the ED stay.
| Intervention | percent lactate clearance (Median) |
|---|---|
| Fluid Optimization (FO) | 54 |
| Routine Care (RC) | 56 |
11 reviews available for lactic acid and MODS
| Article | Year |
|---|---|
Identifying cardiogenic shock in the emergency department.
Topics: Acidosis, Lactic; Bradycardia; Confusion; Early Diagnosis; Echocardiography; Edema; Electrocardiogra | 2020 |
Early recognition of septic shock in children.
Topics: Biomarkers; Cell Hypoxia; Child; Clinical Laboratory Techniques; Early Diagnosis; Hemodynamics; Huma | 2013 |
[Pathophysiology of multiple trauma : intensive care medicine and timing of treatment].
Topics: Blood Coagulation; Cause of Death; Combined Modality Therapy; Cooperative Behavior; Critical Care; D | 2013 |
Management of sepsis: early resuscitation.
Topics: Calcitonin; Critical Care; Hemodynamics; Humans; Lactic Acid; Multiple Organ Failure; Natriuretic Pe | 2008 |
[Evaluation of microcirculation in cardiogenic shock].
Topics: Blood Flow Velocity; Cardiotonic Agents; Combined Modality Therapy; Echocardiography; Equipment Desi | 2010 |
Sublingual capnometry: an alternative to gastric tonometry for the management of shock resuscitation.
Topics: Blood Volume; Capnography; Critical Care; Forecasting; Humans; Lactic Acid; Monitoring, Physiologic; | 2003 |
Mitochondrial function in sepsis: respiratory versus leg muscle.
Topics: Adenosine Triphosphate; Animals; Energy Metabolism; Humans; Lactic Acid; Leg; Locomotion; Mitochondr | 2007 |
Substrate utilization in sepsis and multiple organ failure.
Topics: Critical Illness; Energy Metabolism; Fatty Acids, Omega-3; Fish Oils; Humans; Inflammation Mediators | 2007 |
[Definition of intrapartum asphyxia and effects on outcome].
Topics: Acidosis; Apgar Score; Biomarkers; Brain Diseases; Cerebral Palsy; Female; Fetal Blood; Fetal Hypoxi | 2008 |
[Lactate versus intramucosal pCO2 or pH?].
Topics: Acid-Base Equilibrium; Carbon Dioxide; Gastric Mucosa; Humans; Hydrogen-Ion Concentration; Intestina | 1995 |
Oxygen transport in adult respiratory distress syndrome and other acute circulatory problems: relationship of oxygen delivery and oxygen consumption.
Topics: Biological Transport; Cardiac Output; Humans; Infections; Lactates; Lactic Acid; Multiple Organ Fail | 1991 |
13 trials available for lactic acid and MODS
| Article | Year |
|---|---|
Randomized controlled trial of inhaled nitric oxide for the treatment of microcirculatory dysfunction in patients with sepsis*.
Topics: Academic Medical Centers; Administration, Inhalation; Adult; Aged; Double-Blind Method; Female; Hosp | 2014 |
[Study the effects of high-volume hemofiltration and fluid resuscitation on removing blood lactic acid and pro-inflammatory cytokines in patients with refractory septic shock].
Topics: Adult; Aged; APACHE; Cytokines; Female; Hemofiltration; Humans; Lactic Acid; Male; Middle Aged; Mult | 2009 |
Candidemia as a cause of septic shock and multiple organ failure in nonimmunocompromised patients.
Topics: Adult; Aged; APACHE; Canada; Candidiasis; Cohort Studies; Double-Blind Method; Female; Humans; Immun | 2002 |
Effect of bicarbonate and lactate buffer on glucose and lactate metabolism during hemodiafiltration in patients with multiple organ failure.
Topics: Acid-Base Equilibrium; Aged; Analysis of Variance; Blood Glucose; Buffers; Cross-Over Studies; Femal | 2004 |
Early lactate clearance is associated with improved outcome in severe sepsis and septic shock.
Topics: Biomarkers; Cohort Studies; Emergency Medical Services; Female; Hospital Mortality; Humans; Lactic A | 2004 |
Early lactate clearance is associated with improved outcome in severe sepsis and septic shock.
Topics: Biomarkers; Cohort Studies; Emergency Medical Services; Female; Hospital Mortality; Humans; Lactic A | 2004 |
Early lactate clearance is associated with improved outcome in severe sepsis and septic shock.
Topics: Biomarkers; Cohort Studies; Emergency Medical Services; Female; Hospital Mortality; Humans; Lactic A | 2004 |
Early lactate clearance is associated with improved outcome in severe sepsis and septic shock.
Topics: Biomarkers; Cohort Studies; Emergency Medical Services; Female; Hospital Mortality; Humans; Lactic A | 2004 |
Early lactate clearance is associated with improved outcome in severe sepsis and septic shock.
Topics: Biomarkers; Cohort Studies; Emergency Medical Services; Female; Hospital Mortality; Humans; Lactic A | 2004 |
Early lactate clearance is associated with improved outcome in severe sepsis and septic shock.
Topics: Biomarkers; Cohort Studies; Emergency Medical Services; Female; Hospital Mortality; Humans; Lactic A | 2004 |
Early lactate clearance is associated with improved outcome in severe sepsis and septic shock.
Topics: Biomarkers; Cohort Studies; Emergency Medical Services; Female; Hospital Mortality; Humans; Lactic A | 2004 |
Early lactate clearance is associated with improved outcome in severe sepsis and septic shock.
Topics: Biomarkers; Cohort Studies; Emergency Medical Services; Female; Hospital Mortality; Humans; Lactic A | 2004 |
Early lactate clearance is associated with improved outcome in severe sepsis and septic shock.
Topics: Biomarkers; Cohort Studies; Emergency Medical Services; Female; Hospital Mortality; Humans; Lactic A | 2004 |
Early lactate clearance is associated with improved outcome in severe sepsis and septic shock.
Topics: Biomarkers; Cohort Studies; Emergency Medical Services; Female; Hospital Mortality; Humans; Lactic A | 2004 |
Early lactate clearance is associated with improved outcome in severe sepsis and septic shock.
Topics: Biomarkers; Cohort Studies; Emergency Medical Services; Female; Hospital Mortality; Humans; Lactic A | 2004 |
Early lactate clearance is associated with improved outcome in severe sepsis and septic shock.
Topics: Biomarkers; Cohort Studies; Emergency Medical Services; Female; Hospital Mortality; Humans; Lactic A | 2004 |
Early lactate clearance is associated with improved outcome in severe sepsis and septic shock.
Topics: Biomarkers; Cohort Studies; Emergency Medical Services; Female; Hospital Mortality; Humans; Lactic A | 2004 |
Early lactate clearance is associated with improved outcome in severe sepsis and septic shock.
Topics: Biomarkers; Cohort Studies; Emergency Medical Services; Female; Hospital Mortality; Humans; Lactic A | 2004 |
Early lactate clearance is associated with improved outcome in severe sepsis and septic shock.
Topics: Biomarkers; Cohort Studies; Emergency Medical Services; Female; Hospital Mortality; Humans; Lactic A | 2004 |
Early lactate clearance is associated with improved outcome in severe sepsis and septic shock.
Topics: Biomarkers; Cohort Studies; Emergency Medical Services; Female; Hospital Mortality; Humans; Lactic A | 2004 |
Terlipressin in catecholamine-resistant septic shock patients.
Topics: Alanine Transaminase; Aspartate Aminotransferases; Bilirubin; Blood Platelets; Drug Resistance; Epin | 2004 |
A comparison among portal lactate, intramucosal sigmoid Ph, and deltaCO2 (PaCO2 - regional Pco2) as indices of complications in patients undergoing abdominal aortic aneurysm surgery.
Topics: Aged; Aortic Aneurysm, Abdominal; Blood Gas Analysis; Carbon Dioxide; Colon, Sigmoid; Female; Hemogl | 2004 |
[Effect of total parenteral nutrition with supplementation of glutamine on the plasma diamine oxidase activity and D-lactate content in patients with multiple organ dysfunction syndrome].
Topics: Adult; Aged; Amine Oxidase (Copper-Containing); Female; Glutamine; Humans; Lactic Acid; Male; Middle | 2006 |
[Early goal-directed therapy lowers the incidence, severity and mortality of multiple organ dysfunction syndrome].
Topics: Adult; Aged; APACHE; Female; Humans; Incidence; Lactic Acid; Male; Middle Aged; Multiple Organ Failu | 2007 |
Immediate metabolic effects of different nutritional regimens in critically ill medical patients.
Topics: Aged; Blood Glucose; Blood Urea Nitrogen; Body Temperature; Critical Illness; Energy Intake; Energy | 1995 |
Enalaprilat improves gut perfusion in critically injured patients.
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Digestive System; Enalaprilat; Female; Gastric Muco | 1998 |
Phase II multicenter clinical study of the platelet-activating factor receptor antagonist BB-882 in the treatment of sepsis.
Topics: Adult; Aged; Aged, 80 and over; APACHE; Cytokines; Double-Blind Method; Europe; Female; Hemodynamics | 2000 |
Lactate or bicarbonate for intermittent hemofiltration?
Topics: Acidosis, Lactic; Acute Kidney Injury; Bicarbonates; Buffers; Female; Hemodialysis Solutions; Hemofi | 1991 |
99 other studies available for lactic acid and MODS
| Article | Year |
|---|---|
Risk stratification and prognostic value of serum neutrophil gelatinase-associated lipocalin (sNGAL) in sepsis patients.
Topics: Acute Kidney Injury; Aged; Aged, 80 and over; Biomarkers; Female; Humans; Lactic Acid; Lipocalin-2; | 2022 |
Therapeutic plasma exchange for multiorgan dysfunction among critically ill pediatric patients with leukemia: A single-institutional experience.
Topics: Adult; Blood Component Removal; Child; Critical Illness; Humans; Lactic Acid; Leukemia; Multiple Org | 2022 |
Prospective validation of a transcriptomic severity classifier among patients with suspected acute infection and sepsis in the emergency department.
Topics: Biomarkers; Emergency Service, Hospital; Hospital Mortality; Humans; Infections; Lactic Acid; Multip | 2022 |
The Association of the Lactate-Albumin Ratio With Mortality and Multiple Organ Dysfunction in PICU Patients.
Topics: Albumins; Child; Critical Illness; Humans; Intensive Care Units, Pediatric; Lactic Acid; Multiple Or | 2023 |
S-Adenosylhomocysteine Is a Useful Metabolic Factor in the Early Prediction of Septic Disease Progression and Death in Critically Ill Patients: A Prospective Cohort Study.
Topics: Critical Illness; Disease Progression; Humans; Hypoxia; Lactic Acid; Multiple Organ Failure; Oxygen; | 2023 |
The Lactate-Albumin Ratio Predicts Multiple Organ Dysfunction Syndrome and Death, But Is It Ready to Use?
Topics: Humans; Lactic Acid; Multiple Organ Failure; Serum Albumin, Human | 2023 |
Associations between clinical characteristics and the development of multiple organ failure after severe burns in adult patients.
Topics: Adult; Age Factors; Area Under Curve; Body Surface Area; Burns; Comorbidity; Debridement; Diabetes M | 2019 |
Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children.
Topics: Adolescent; Anti-Bacterial Agents; Child; Child, Preschool; Evidence-Based Medicine; Fluid Therapy; | 2020 |
Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children.
Topics: Adolescent; Anti-Bacterial Agents; Child; Child, Preschool; Evidence-Based Medicine; Fluid Therapy; | 2020 |
Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children.
Topics: Adolescent; Anti-Bacterial Agents; Child; Child, Preschool; Evidence-Based Medicine; Fluid Therapy; | 2020 |
Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children.
Topics: Adolescent; Anti-Bacterial Agents; Child; Child, Preschool; Evidence-Based Medicine; Fluid Therapy; | 2020 |
Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children.
Topics: Adolescent; Anti-Bacterial Agents; Child; Child, Preschool; Evidence-Based Medicine; Fluid Therapy; | 2020 |
Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children.
Topics: Adolescent; Anti-Bacterial Agents; Child; Child, Preschool; Evidence-Based Medicine; Fluid Therapy; | 2020 |
Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children.
Topics: Adolescent; Anti-Bacterial Agents; Child; Child, Preschool; Evidence-Based Medicine; Fluid Therapy; | 2020 |
Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children.
Topics: Adolescent; Anti-Bacterial Agents; Child; Child, Preschool; Evidence-Based Medicine; Fluid Therapy; | 2020 |
Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children.
Topics: Adolescent; Anti-Bacterial Agents; Child; Child, Preschool; Evidence-Based Medicine; Fluid Therapy; | 2020 |
Plasma lactate can improve the accuracy of the Pediatric Sequential Organ Failure Assessment Score for prediction of mortality in critically ill children: A pilot study.
Topics: Adolescent; Biomarkers; Child; Child, Preschool; Clinical Decision Rules; Critical Illness; Female; | 2020 |
Initially elevated arterial lactate as an independent predictor of poor outcomes in severe acute pancreatitis.
Topics: Adult; Aged; Arteries; Female; Humans; Intra-Abdominal Hypertension; Lactic Acid; Male; Middle Aged; | 2020 |
Combining the serum lactic acid level and the lactate clearance rate into the CLIF-SOFA score for evaluating the short-term prognosis of HBV-related ACLF patients.
Topics: Acute-On-Chronic Liver Failure; Adult; Female; Hepatitis B, Chronic; Humans; Lactic Acid; Male; Midd | 2020 |
Laboratory Markers of Acidosis and Mortality in Cardiogenic Shock: Developing a Definition of Hemometabolic Shock.
Topics: Acid-Base Equilibrium; Acidosis; Aged; Biomarkers; Female; Hospital Mortality; Humans; Intensive Car | 2022 |
Mechanistic insights into cell-free hemoglobin-induced injury during septic shock.
Topics: Acidosis; Acute Lung Injury; Animals; Blood Pressure; Dogs; Heart Ventricles; Hemoglobins; Iron; Lac | 2021 |
Clinical predictors of early death from sepsis.
Topics: Adult; Aged; Disease Progression; Emergency Service, Hospital; Female; Hospitalization; Humans; Lact | 2017 |
Attenuation of Multiple Organ Damage by Continuous Low-Dose Solvent-Free Infusions of Resveratrol after Severe Hemorrhagic Shock in Rats.
Topics: Animals; Blood Glucose; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; He | 2017 |
Liver transplantation in critically ill patients: Preoperative predictive factors of post-transplant mortality to avoid futility.
Topics: Adult; Critical Illness; Female; Follow-Up Studies; Graft Rejection; Humans; Lactic Acid; Liver Fail | 2017 |
Systemic Inflammatory Response and Multiple Organ Dysfunctions Following Crush Injury: a New Experimental Model in Rabbits.
Topics: Animals; Biomarkers; Body Temperature Regulation; Body Weight; Carbon Dioxide; Crush Injuries; Cytok | 2018 |
Lactate ≥2 mmol/L plus qSOFA improves utility over qSOFA alone in emergency department patients presenting with suspected sepsis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Australia; Cohort Studies; Emergency Service, Hospital; | 2017 |
Does Lactate Affect the Association of Early Hyperglycemia and Multiple Organ Failure in Severely Injured Blunt Trauma Patients?
Topics: Adult; Biomarkers; Blood Glucose; Cohort Studies; Female; Humans; Hyperglycemia; Injury Severity Sco | 2018 |
Determination of plasma lactate in the emergency department for the early detection of tissue hypoperfusion in septic patients.
Topics: Adult; Aged; Biomarkers; Early Diagnosis; Emergency Medical Services; Female; Humans; Lactic Acid; L | 2018 |
Hyperglycemia and Elevated Lactate in Trauma: Where Do We Go From Here?
Topics: Humans; Hyperglycemia; Lactic Acid; Multiple Organ Failure; Wounds, Nonpenetrating | 2018 |
62-Year-Old Man With Encephalopathy and Fatigue After Allogeneic Bone Marrow Transplant.
Topics: Bone Marrow Transplantation; Brain Diseases; Consciousness Disorders; Cytomegalovirus Infections; Ep | 2018 |
The role of perioperative cardiorespiratory support in post infarction ventricular septal rupture-related cardiogenic shock.
Topics: Aged; Aged, 80 and over; Alanine Transaminase; Case-Control Studies; Creatinine; Extracorporeal Memb | 2020 |
Prognostic factors of acute mesenteric ischemia in ICU patients.
Topics: Acute Disease; Aged; Aged, 80 and over; Anticoagulants; Comorbidity; Female; Hospital Mortality; Hum | 2019 |
Successful Intensive Care Treatment of Severe Lactic Acidosis and Tumor Lysis Syndrome Related to Intravascular Lymphoma.
Topics: Acidosis; Antineoplastic Combined Chemotherapy Protocols; Critical Care; Cyclophosphamide; Doxorubic | 2020 |
Changes in plasma kynurenic acid concentration in septic shock patients undergoing continuous veno-venous haemofiltration.
Topics: Acute Kidney Injury; Bacterial Infections; Biomarkers; C-Reactive Protein; Calcitonin; Calcitonin Ge | 2014 |
Sustained high serum malondialdehyde levels are associated with severity and mortality in septic patients.
Topics: Aged; APACHE; Female; Hospital Mortality; Humans; Intensive Care Units; Lactic Acid; Male; Malondial | 2013 |
Persistently high venous-to-arterial carbon dioxide differences during early resuscitation are associated with poor outcomes in septic shock.
Topics: Aged; Carbon Dioxide; Cardiac Output; Female; Hemodynamics; Humans; Lactic Acid; Male; Middle Aged; | 2013 |
Persistently high venous-to-arterial carbon dioxide differences during early resuscitation are associated with poor outcomes in septic shock.
Topics: Aged; Carbon Dioxide; Cardiac Output; Female; Hemodynamics; Humans; Lactic Acid; Male; Middle Aged; | 2013 |
Persistently high venous-to-arterial carbon dioxide differences during early resuscitation are associated with poor outcomes in septic shock.
Topics: Aged; Carbon Dioxide; Cardiac Output; Female; Hemodynamics; Humans; Lactic Acid; Male; Middle Aged; | 2013 |
Persistently high venous-to-arterial carbon dioxide differences during early resuscitation are associated with poor outcomes in septic shock.
Topics: Aged; Carbon Dioxide; Cardiac Output; Female; Hemodynamics; Humans; Lactic Acid; Male; Middle Aged; | 2013 |
Persistently high venous-to-arterial carbon dioxide differences during early resuscitation are associated with poor outcomes in septic shock.
Topics: Aged; Carbon Dioxide; Cardiac Output; Female; Hemodynamics; Humans; Lactic Acid; Male; Middle Aged; | 2013 |
Persistently high venous-to-arterial carbon dioxide differences during early resuscitation are associated with poor outcomes in septic shock.
Topics: Aged; Carbon Dioxide; Cardiac Output; Female; Hemodynamics; Humans; Lactic Acid; Male; Middle Aged; | 2013 |
Persistently high venous-to-arterial carbon dioxide differences during early resuscitation are associated with poor outcomes in septic shock.
Topics: Aged; Carbon Dioxide; Cardiac Output; Female; Hemodynamics; Humans; Lactic Acid; Male; Middle Aged; | 2013 |
Persistently high venous-to-arterial carbon dioxide differences during early resuscitation are associated with poor outcomes in septic shock.
Topics: Aged; Carbon Dioxide; Cardiac Output; Female; Hemodynamics; Humans; Lactic Acid; Male; Middle Aged; | 2013 |
Persistently high venous-to-arterial carbon dioxide differences during early resuscitation are associated with poor outcomes in septic shock.
Topics: Aged; Carbon Dioxide; Cardiac Output; Female; Hemodynamics; Humans; Lactic Acid; Male; Middle Aged; | 2013 |
Severe lactic acidosis and multiorgan failure due to thiamine deficiency during total parenteral nutrition.
Topics: Acidosis, Lactic; Adolescent; Diagnosis, Differential; Humans; Hydrogen-Ion Concentration; Lactic Ac | 2014 |
["Bridge to recovery"- implantation of an Impella® CP in infarct-related cardiogenic shock].
Topics: Adult; Angioplasty, Balloon, Coronary; Cardiopulmonary Resuscitation; Coronary Angiography; Critical | 2015 |
Correlation of lactate/albumin ratio level to organ failure and mortality in severe sepsis and septic shock.
Topics: Adult; Aged; APACHE; Female; Humans; Intensive Care Units; Lactic Acid; Logistic Models; Male; Middl | 2015 |
D-dimer as an early marker of severity in patients with acute superior mesenteric venous thrombosis.
Topics: Adult; APACHE; Biomarkers; Early Diagnosis; Fatty Acid-Binding Proteins; Female; Fibrin Fibrinogen D | 2014 |
[Efficacies of continuous high volume hemofiltration in severe sepsis patients with multiple organ dysfunction syndrome].
Topics: Heart Rate; Hemodynamics; Hemofiltration; Humans; Lactic Acid; Multiple Organ Failure; Renal Dialysi | 2015 |
Lactate Testing in Suspected Sepsis: Trends and Predictors of Failure to Measure Levels.
Topics: Aged; Anti-Bacterial Agents; Female; Hospital Mortality; Humans; Lactic Acid; Male; Middle Aged; Mul | 2015 |
Protective effects of polyethylene oxide on the vascular and organ function of rats with severe hemorrhagic shock.
Topics: Animals; Biomarkers; Disease Models, Animal; Fluid Therapy; Hemodynamics; Inflammation Mediators; In | 2015 |
Dengue infection with multiorgan dysfunction: SOFA score, arterial lactate and serum albumin levels are predictors of outcome.
Topics: Adult; Biomarkers; Humans; India; Intensive Care Units; Lactic Acid; Multiple Organ Failure; Organ D | 2015 |
Long-Term β-Blocker Therapy Decreases Blood Lactate Concentration in Severely Septic Patients.
Topics: Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Biomarkers; Emergency Service, Hospital; Femal | 2015 |
Early alterations in platelet mitochondrial function are associated with survival and organ failure in patients with septic shock.
Topics: Adult; Aged; Blood Platelets; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cohort Studies; Fe | 2016 |
Lactate Clearance and Normalization and Prolonged Organ Dysfunction in Pediatric Sepsis.
Topics: Biomarkers; Child; Cohort Studies; Emergency Service, Hospital; Humans; Hypotension; Lactic Acid; Mu | 2016 |
Acute paraquat exposure determines dose-dependent oxidative injury of multiple organs and metabolic dysfunction in rats: impact on exercise tolerance.
Topics: Animals; Antioxidants; Blood Glucose; Dose-Response Relationship, Drug; Exercise Tolerance; Herbicid | 2016 |
[Outcome of extracorporeal membrane oxygenation support for adult patients in Fuwai Hospital during the last 10 years: treatment strategy and risk factors].
Topics: Adult; Cardiopulmonary Resuscitation; Extracorporeal Membrane Oxygenation; Female; Gastrointestinal | 2015 |
Serum Procalcitonin and Peripheral Venous Lactate for Predicting Dengue Shock and/or Organ Failure: A Prospective Observational Study.
Topics: Adolescent; Adult; Aged; Biomarkers; Calcitonin; Dengue Virus; Female; Hospitalization; Humans; Lact | 2016 |
Acute intestinal damage following severe burn correlates with the development of multiple organ dysfunction syndrome: A prospective cohort study.
Topics: Adult; Aged; Alanine Transaminase; Amylases; APACHE; Aspartate Aminotransferases; Biomarkers; Body S | 2017 |
Predictive Factors of Intestinal Necrosis in Acute Mesenteric Ischemia: Prospective Study from an Intestinal Stroke Center.
Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Area Under Curve; Cohort Studies; Digesti | 2017 |
Insulin resistance and beta cell function as prognostic indicator in multi-organ dysfunction syndrome.
Topics: Adolescent; Adult; Aged; APACHE; Bicarbonates; Blood Glucose; Critical Illness; Disease Progression; | 2009 |
Association between blood lactate levels, Sequential Organ Failure Assessment subscores, and 28-day mortality during early and late intensive care unit stay: a retrospective observational study.
Topics: Aged; Biomarkers; Early Diagnosis; Female; Hospital Mortality; Humans; Intensive Care Units; Lactic | 2009 |
Regional occult hypoperfusion detected by lactate and Sequential Organ Failure Assessment subscores: old tools for new tricks?
Topics: Biomarkers; Humans; Ischemia; Lactic Acid; Multiple Organ Failure; Severity of Illness Index | 2009 |
Lactate: an unusually sensitive parameter of ensuing organ failure?
Topics: Biomarkers; Cause of Death; Critical Care; Critical Illness; Female; Hospital Mortality; Humans; Int | 2010 |
Out-of-hospital characteristics and care of patients with severe sepsis: a cohort study.
Topics: Academic Medical Centers; Aged; Emergency Medical Services; Female; Humans; Lactic Acid; Male; Middl | 2010 |
C-reactive protein is not a useful indicator for infection in surgical intensive care units.
Topics: Analysis of Variance; Biomarkers; C-Reactive Protein; Critical Care; Female; Humans; Lactic Acid; Ma | 2009 |
Is early lactate level helpful in guiding treatment?
Topics: Aged, 80 and over; Biomarkers; Critical Care; Critical Illness; Hospital Mortality; Humans; Kaplan-M | 2011 |
Imbalance of arginine and asymmetric dimethylarginine is associated with markers of circulatory failure, organ failure and mortality in shock patients.
Topics: Aged; Area Under Curve; Arginine; Biomarkers; Blood Coagulation; Blood Glucose; Carbonates; Creatine | 2012 |
4G/5G Polymorphism of the plasminogen activator inhibitor-1 gene is associated with multiple organ dysfunction in critically ill patients.
Topics: Adult; Aged; Aged, 80 and over; Critical Illness; Female; Humans; Japan; Lactic Acid; Male; Middle A | 2012 |
[Measurement of lactic acid in multiple injury patients and its usefulness as a predictor of multiorgan failure and mortality].
Topics: Adult; Humans; Lactic Acid; Middle Aged; Multiple Organ Failure; Multiple Trauma; Predictive Value o | 2012 |
Comparison of the sequential organ failure assessment score with the King's College Hospital criteria and the model for end-stage liver disease score for the prognosis of acetaminophen-induced acute liver failure.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; APACHE; Biomarkers; Chemical and Drug Induced Liver | 2012 |
The dynamics of angiogenic factors and their soluble receptors in relation to organ dysfunction in disseminated intravascular coagulation associated with sepsis.
Topics: Angiogenesis Inducing Agents; Angiopoietin-1; Angiopoietin-2; Blood Platelets; Cell Hypoxia; Dissemi | 2013 |
[Diagnostics and treatment of the ischemic and reperfusion disorders by the intraabdominal ischemic syndrome].
Topics: Abdominal Cavity; Adult; Algorithms; Animals; Combined Modality Therapy; Decompression, Surgical; Fe | 2012 |
Determination of glyphosate and AMPA in blood and urine from humans: about 13 cases of acute intoxication.
Topics: Accidents; Acidosis; Adult; Aged; Arrhythmias, Cardiac; Chemical and Drug Induced Liver Injury; Chro | 2013 |
A 24-h pneumoperitoneum leads to multiple organ impairment in a porcine model.
Topics: Alkaline Phosphatase; Animals; Blood Pressure; Cardiac Output; Central Venous Pressure; Compartment | 2002 |
[Utility of sigmoid intramucosal pH in the early diagnosis of ischemic colitis after aorta surgery].
Topics: Aorta, Abdominal; Aortic Aneurysm, Abdominal; Aortic Rupture; Axillary Artery; Carbon Dioxide; Colit | 2002 |
Low exogenous lactate clearance as an early predictor of mortality in normolactatemic critically ill septic patients.
Topics: Age Distribution; Age Factors; Aged; Blood Gas Analysis; Comorbidity; Critical Illness; Female; Hosp | 2003 |
Occult hypoperfusion is associated with increased mortality in hemodynamically stable, high-risk, surgical patients.
Topics: Adult; Aged; Biomarkers; Critical Illness; Female; Hemodynamics; Humans; Hypoxia; Intensive Care Uni | 2004 |
Septic shock of early or late onset: does it matter?
Topics: Aged; APACHE; Comorbidity; Critical Care; Data Collection; Female; Humans; Intensive Care Units; Lac | 2004 |
Early veno-venous haemodiafiltration for sepsis-related multiple organ failure.
Topics: Acid-Base Imbalance; Acute Kidney Injury; Electrolytes; Female; Hemofiltration; Humans; Lactic Acid; | 2005 |
Prognostic implications of hyperlactatemia, multiple organ failure, and systemic inflammatory response syndrome in patients with acetaminophen-induced acute liver failure.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Child; Female; Hepatic Encephalopa | 2006 |
[Influence of glucose-insulin-potassium on the levels of inflammatory cytokines and prognosis of MODS in the scalded rats].
Topics: Animals; Blood Glucose; Burns; Cytokines; Disease Models, Animal; Glucose; Insulin; Lactic Acid; Mul | 2005 |
Derangements in mitochondrial metabolism in intercostal and leg muscle of critically ill patients with sepsis-induced multiple organ failure.
Topics: Adenosine Triphosphate; Adult; Aged; Aged, 80 and over; Biopsy; Citrate (si)-Synthase; Critical Illn | 2006 |
Comparison of three different methods of evaluation of metabolic acid-base disorders.
Topics: Acid-Base Imbalance; Aged; Albumins; Anions; Area Under Curve; Bicarbonates; Female; Humans; Hydroge | 2007 |
Caecal ligation and puncture in the rat mimics the pathophysiological changes in human sepsis and causes multi-organ dysfunction.
Topics: Animals; Blood Glucose; Body Temperature; Body Weight; Cecum; Disease Models, Animal; Eating; Humans | 2007 |
Delayed hypothermia as selective head cooling or whole body cooling does not protect brain or body in newborn pig subjected to hypoxia-ischemia.
Topics: Animals; Animals, Newborn; Anticonvulsants; Calcium; Cardiotonic Agents; Disease Models, Animal; Fem | 2008 |
Increased oxygen affinity contributes to tissue hypoxia in critically ill patients with low oxygen delivery.
Topics: Biological Transport, Active; Critical Illness; Humans; Hypoxia; Lactates; Lactic Acid; Multiple Org | 1994 |
The significance of changes in serum tumour necrosis factor (TNF) activity in severely burned patients.
Topics: Adolescent; Adult; Blood Cell Count; Blood Glucose; Blood Proteins; Burns; Female; Humans; Lactates; | 1994 |
Assessment of splanchnic oxygenation by gastric tonometry in patients with acute circulatory failure.
Topics: Aged; Blood Chemical Analysis; Critical Illness; Digestive System Physiological Phenomena; Female; G | 1993 |
Identification of the critical oxygen delivery for anaerobic metabolism in critically ill septic and nonseptic humans.
Topics: Adult; Aged; Bacterial Infections; Calorimetry, Indirect; Cell Hypoxia; Cohort Studies; Critical Ill | 1993 |
Serial blood lactate levels can predict the development of multiple organ failure following septic shock.
Topics: Adult; Aged; Aged, 80 and over; Female; Humans; Lactates; Lactic Acid; Male; Middle Aged; Multiple O | 1996 |
Initial postoperative serum lactate levels predict survival in children after open heart surgery.
Topics: Adolescent; Cardiac Surgical Procedures; Child; Child, Preschool; Heart Defects, Congenital; Humans; | 1996 |
The regional production of cytokines and lactate in sepsis-related multiple organ failure.
Topics: Aged; Craniocerebral Trauma; Cytokines; Female; Humans; Interleukin-1; Interleukin-6; Lactic Acid; L | 1997 |
Effects of tyrphostins and genistein on the circulatory failure and organ dysfunction caused by endotoxin in the rat: a possible role for protein tyrosine kinase.
Topics: Acidosis, Lactic; Animals; Cells, Cultured; Cyclooxygenase 2; Endotoxemia; Endotoxins; Enzyme Induct | 1997 |
Early markers of major adverse events in children after cardiac operations.
Topics: Blood Pressure; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cohort Studies; Heart Arrest; H | 1997 |
Effects of inhibitors of poly(ADP-ribose) synthetase activity on hypotension and multiple organ dysfunction caused by endotoxin.
Topics: Animals; Benzamides; Endotoxemia; Enzyme Inhibitors; Hemodynamics; Hypotension; Isoquinolines; Kidne | 1998 |
Cellular injury score for multiple organ failure severity scoring system.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adult; Aged; Blood Gas Analysis; Cell Hypoxia; Female; Humans; | 1998 |
Elevated arterial base deficit in trauma patients: a marker of impaired oxygen utilization.
Topics: Acid-Base Imbalance; Adult; Aged; Cell Respiration; Female; Hemodynamics; Humans; Lactic Acid; Linea | 1998 |
Adenosine-triphosphate in trauma-related and elective hypothermia.
Topics: Adenosine Triphosphate; Adolescent; Adult; Body Temperature; Coronary Artery Bypass; Elective Surgic | 1999 |
The golden hour and the silver day: detection and correction of occult hypoperfusion within 24 hours improves outcome from major trauma.
Topics: Acidosis, Lactic; Adult; Critical Care; Female; Hemodynamics; Humans; Injury Severity Score; Ischemi | 1999 |
The golden hour and the silver day: detection and correction of occult hypoperfusion within 24 hours improves outcome from major trauma.
Topics: Acidosis, Lactic; Adult; Critical Care; Female; Hemodynamics; Humans; Injury Severity Score; Ischemi | 1999 |
The golden hour and the silver day: detection and correction of occult hypoperfusion within 24 hours improves outcome from major trauma.
Topics: Acidosis, Lactic; Adult; Critical Care; Female; Hemodynamics; Humans; Injury Severity Score; Ischemi | 1999 |
The golden hour and the silver day: detection and correction of occult hypoperfusion within 24 hours improves outcome from major trauma.
Topics: Acidosis, Lactic; Adult; Critical Care; Female; Hemodynamics; Humans; Injury Severity Score; Ischemi | 1999 |
Polytrauma induces increased expression of pyruvate kinase in neutrophils.
Topics: Adult; Aged; Cells, Cultured; Enzyme Induction; Female; Glycolysis; Humans; Lactic Acid; Male; Middl | 2000 |
Redox pairs, tissue hypoxia, organ dysfunction, and mortality.
Topics: Humans; Hypoxia; Ketone Bodies; Lactic Acid; Multiple Organ Failure; Oxidation-Reduction; Predictive | 2000 |
Time-pattern of lactate and lactate to pyruvate ratio in the first 24 hours of intensive care emergency admissions.
Topics: Acidosis, Lactic; APACHE; Biomarkers; Critical Care; Emergencies; Female; Finland; Glasgow Coma Scal | 2000 |
Thyroid storm presenting as multiple organ dysfunction syndrome.
Topics: Adult; Antithyroid Agents; Diagnosis, Differential; Female; Humans; Iodine Radioisotopes; Lactic Aci | 2000 |
Lactate: may I have your votes please?
Topics: Acidosis; Humans; Intensive Care Units; Lactic Acid; Multiple Organ Failure; Prognosis | 2001 |
Base excess and lactate as prognostic indicators for patients admitted to intensive care.
Topics: Acid-Base Equilibrium; Acidosis; Adult; Aged; Aged, 80 and over; Blood Gas Analysis; Female; Hospita | 2001 |
Base excess and lactate as prognostic indicators for patients admitted to intensive care.
Topics: Acid-Base Equilibrium; Acidosis; Adult; Aged; Aged, 80 and over; Blood Gas Analysis; Female; Hospita | 2001 |
Base excess and lactate as prognostic indicators for patients admitted to intensive care.
Topics: Acid-Base Equilibrium; Acidosis; Adult; Aged; Aged, 80 and over; Blood Gas Analysis; Female; Hospita | 2001 |
Base excess and lactate as prognostic indicators for patients admitted to intensive care.
Topics: Acid-Base Equilibrium; Acidosis; Adult; Aged; Aged, 80 and over; Blood Gas Analysis; Female; Hospita | 2001 |
TNF-alpha increases sensitivity to LPS in chronically catheterized rats.
Topics: Animals; Catheterization; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Infus | 2001 |
Mitochondrial DNA depletion presenting prenatally with skin edema and multisystem disease immediately after birth.
Topics: Consanguinity; DNA; DNA, Mitochondrial; Edema; Female; Fetal Diseases; Fetal Movement; Gestational A | 2002 |
Osmolar gap hyponatremia in critically ill patients: evidence for the sick cell syndrome?
Topics: Amino Acids; Critical Illness; Female; Humans; Hyponatremia; Ketone Bodies; Lactic Acid; Male; Middl | 2002 |
The lethal form of Cushing's in 7B2 null mice is caused by multiple metabolic and hormonal abnormalities.
Topics: Adrenocorticotropic Hormone; Animals; Blood Glucose; Cause of Death; Corticosterone; Cushing Syndrom | 2002 |
A narrow range, medium molecular weight pentastarch reduces structural organ damage in a hyperdynamic porcine model of sepsis.
Topics: Biopsy; Blood Flow Velocity; Blood Gas Analysis; Disease Models, Animal; Drug Evaluation, Preclinica | 1992 |
Changes in ceruloplasmin activity and lactate concentration in patients at high risk of acute organ system failure.
Topics: Adult; Ceruloplasmin; Female; Humans; Lactates; Lactic Acid; Male; Middle Aged; Multiple Organ Failu | 1991 |
[Acute renal failure in patients with multiple organ failure].
Topics: Acute Kidney Injury; Hemofiltration; Humans; Ketone Bodies; Lactates; Lactic Acid; Multiple Organ Fa | 1991 |
Lactate and acid base changes in the critically ill.
Topics: Acidosis, Lactic; Adult; Aged; Aged, 80 and over; Catecholamines; Hemofiltration; Humans; Lactates; | 1991 |
[Cellular metabolic consideration in the pathophysiology and the treatment of shock].
Topics: Humans; Ketone Bodies; Lactates; Lactic Acid; Multiple Organ Failure; Osmolar Concentration; Oxygen; | 1989 |