lactic acid has been researched along with MELAS Syndrome in 45 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
MELAS Syndrome: A mitochondrial disorder characterized by focal or generalized seizures, episodes of transient or persistent neurologic dysfunction resembling strokes, and ragged-red fibers on muscle biopsy. Affected individuals tend to be normal at birth through early childhood, then experience growth failure, episodic vomiting, and recurrent cerebral insults resulting in visual loss and hemiparesis. The cortical lesions tend to occur in the parietal and occipital lobes and are not associated with vascular occlusion. VASCULAR HEADACHE is frequently associated and the disorder tends to be familial. (From Joynt, Clinical Neurology, 1992, Ch56, p117)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the role of chronic cerebral lactic acidosis in mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS)." | 9.11 | Cerebral lactic acidosis correlates with neurological impairment in MELAS. ( De Vivo, DC; DiMauro, S; Engelstad, K; Hirano, M; Jhung, S; Kaufmann, P; Mao, X; Mitsis, E; Sano, MC; Shanske, S; Shungu, DC, 2004) |
| "Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is a genetically heterogeneous disorder caused by mitochondrial DNA (mtDNA) mutations in the MT-TL1 gene." | 8.12 | Elevated glutamate and decreased glutamine levels in the cerebrospinal fluid of patients with MELAS syndrome. ( Arenas, J; Arranz-Canales, E; Delmiro, A; Domínguez-González, C; González de la Aleja, J; Guerrero-Molina, MP; Martín, MA; Morales-Conejo, M; Morán, M; Ramos-González, A, 2022) |
| "A 53-year-old man with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) underwent a gastrectomy." | 7.74 | Anesthetic management of a patient with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) during laparotomy. ( Fujita, Y; Katsuya, H; Sasano, H; Sasano, N; So, M; Sobue, K, 2007) |
| " The patient was diagnosed with mitochondrial encephalomyopathy with lactic acidosis and strokelike episodes (MELAS)." | 7.72 | Mitochondrial encephalomyopathy with lactic acidosis and strokelike episodes (MELAS): a mitochondrial disorder presents as fibromyalgia. ( Cardenas, RJ; De la Fuente, FA; DeSouza, RA; Lindler, TU; Mayorquin, FJ; Trochtenberg, DS, 2004) |
| "We here reported the clinical course and therapeutic details of a 16-year-old girl with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) who had had five stroke-like episodes (two episodes were clinically mild, while the three subsequent episodes were severe)." | 7.72 | Beneficial effect of L-arginine for stroke-like episode in MELAS. ( Kubota, M; Momoi-Yoshida, M; Mori, M; Sakakihara, Y; Yamagata, T, 2004) |
| " Other mitochondrial diseases are characterized by focal brain lesions, which is a core feature of MELAS syndrome (mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes)." | 5.41 | Neuroimaging in mitochondrial disease. ( Distelmaier, F; Klopstock, T, 2023) |
| "3243A>G variant is the most common heteroplasmic mitochondrial DNA mutation and underlies a spectrum of diseases, notably mitochondrial encephalomyopathy lactic acidosis and stroke-like episodes (MELAS)." | 5.41 | Circulating markers of NADH-reductive stress correlate with mitochondrial disease severity. ( Clish, CB; De Vivo, DC; Engelstad, K; Fryer, R; Haller, RG; Hirano, M; Khatri, A; Mao, X; Mootha, VK; Oglesbee, D; Pierce, K; Reinstadler, B; Sharma, R; Shungu, DC; Skinner, OS; Stackowitz, E; Walker, MA, 2021) |
| "Increasing evidence from pathological and biochemical investigations suggests that mitochondrial metabolic impairment and oxidative stress play a crucial role in the pathogenesis of mitochondrial diseases, such as mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome, and various neurodegenerative disorders." | 5.12 | Molecular imaging for mitochondrial metabolism and oxidative stress in mitochondrial diseases and neurodegenerative disorders. ( Ikawa, M; Okazawa, H; Yoneda, M, 2021) |
| "The long-term effects of the sodium salt of dichloroacetic acid (DCA) were evaluated in four patients with mitochondrial encephalomyelopathy with lactic acidosis and stroke-like episodes (MELAS) carrying A3243G mutation." | 5.11 | Dichloroacetate treatment for mitochondrial cytopathy: long-term effects in MELAS. ( Goto, T; Momoi, MY; Mori, M; Saito, S; Yamagata, T, 2004) |
| "To evaluate the role of chronic cerebral lactic acidosis in mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS)." | 5.11 | Cerebral lactic acidosis correlates with neurological impairment in MELAS. ( De Vivo, DC; DiMauro, S; Engelstad, K; Hirano, M; Jhung, S; Kaufmann, P; Mao, X; Mitsis, E; Sano, MC; Shanske, S; Shungu, DC, 2004) |
| "To examine the correlation between verbal and visual memory function and correlation with brain metabolites (lactate and N-Acetylaspartate, NAA) in individuals with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS)." | 4.12 | Visual memory failure presages conversion to MELAS phenotype. ( De Vivo, DC; DiMauro, S; Engelstad, K; Fryer, RH; Gu, Y; Hinton, VJ; Hirano, M; Leaffer, EB; Shungu, DC, 2022) |
| "Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is a genetically heterogeneous disorder caused by mitochondrial DNA (mtDNA) mutations in the MT-TL1 gene." | 4.12 | Elevated glutamate and decreased glutamine levels in the cerebrospinal fluid of patients with MELAS syndrome. ( Arenas, J; Arranz-Canales, E; Delmiro, A; Domínguez-González, C; González de la Aleja, J; Guerrero-Molina, MP; Martín, MA; Morales-Conejo, M; Morán, M; Ramos-González, A, 2022) |
| " A 48-week, prospective, single-centre, exploratory, clinical study enrolled 11 Japanese adult patients with genetically, biochemically, and clinically confirmed mitochondrial disease; they had intractable lactic acidosis and received SP (0." | 3.91 | Biomarkers and clinical rating scales for sodium pyruvate therapy in patients with mitochondrial disease. ( Inoue, E; Koga, Y; Nashiki, K; Povalko, N; Tanaka, M, 2019) |
| " Mutation carriers included 45 patients with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS); 11 participants who would develop the MELAS syndrome during follow-up (converters); and 79 participants who would not develop the MELAS syndrome during follow-up (nonconverters)." | 3.80 | Cerebral metabolic abnormalities in A3243G mitochondrial DNA mutation carriers. ( De Vivo, D; DiMauro, S; Engelstad, KM; Hinton, V; Kaufmann, P; Mao, X; Shungu, D; Weiduschat, N, 2014) |
| "Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) is a mitochondrial disease caused by mutations in the mitochondrial genome." | 3.80 | β-Lapachone attenuates mitochondrial dysfunction in MELAS cybrid cells. ( Jeong, MH; Kim, JH; Kwak, TH; Park, WJ; Seo, KS, 2014) |
| "A stroke-like episode is a core symptom in mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS)." | 3.79 | Transient ischemic attack-like episodes without stroke-like lesions in MELAS. ( Aida, N; Mitani, T; Osaka, H; Tomiyasu, M; Wada, T, 2013) |
| "To clarify the roles of serial MR spectroscopy (MRS) and continuous arterial spin labeling (CASL) perfusion images for evaluating cerebral lesions in patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS)." | 3.76 | Pathophysiologic evaluation of MELAS strokes by serially quantified MRS and CASL perfusion images. ( Ikawa, M; Kimura, H; Kudo, T; Kuriyama, M; Okazawa, H; Shimizu, Y; Toyooka, M; Tsujikawa, T; Uematsu, H; Yoneda, M, 2010) |
| "Maternally inherited diabetes and deafness (MIDD) and myoencephalopathy, lactic acidosis, stroke-like episodes (MELAS) syndromes are characterized by the same A3243G mutation of mitochondrial DNA (mtDNA)." | 3.75 | Brain anomalies in maternally inherited diabetes and deafness syndrome. ( Cozzone, PJ; Felician, O; Fromont, I; Lebail, B; Lefur, Y; Mancini, J; Nicoli, F; Paquis-Flucklinger, V; Valéro, R; Vialettes, B, 2009) |
| "A 53-year-old man with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) underwent a gastrectomy." | 3.74 | Anesthetic management of a patient with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) during laparotomy. ( Fujita, Y; Katsuya, H; Sasano, H; Sasano, N; So, M; Sobue, K, 2007) |
| " Among them, there were 19 cases of mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS), 2 cases of encephalopathies which could not be classified into any specific type, 2 cases of floppy infants, one case of Kearns-Sayer syndrome (KSS) and one case of mitochondrial entero-myopathy." | 3.73 | [Phenotype heterogeneity associated with mitochondrial DNA A3243G mutation]. ( Niu, SL; Pei, P; Qi, Y; Wang, ZX; Xu, YF; Yang, YL; Yuan, Y; Zhang, Y, 2005) |
| "To study the characteristics of spectra on proton magnetic resonance spectroscopy (1H-MRS) and its value in patients with mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS)." | 3.73 | Evaluation of mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes with magnetic resonance imaging and proton magnetic resonance spectroscopy. ( Feng, F; Gao, J; Guo, YP; Jin, ZY; Li, XZ; Meng, CL; Sun, HY; You, H, 2006) |
| "The mechanism of neurological disturbances in patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) is controversial." | 3.72 | Comparison of conventional and diffusion-weighted MRI and proton MR spectroscopy in patients with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like events. ( Abe, K; Fujita, N; Hikita, T; Sakoda, S; Tanaka, H; Yoshimura, H, 2004) |
| " The patient was diagnosed with mitochondrial encephalomyopathy with lactic acidosis and strokelike episodes (MELAS)." | 3.72 | Mitochondrial encephalomyopathy with lactic acidosis and strokelike episodes (MELAS): a mitochondrial disorder presents as fibromyalgia. ( Cardenas, RJ; De la Fuente, FA; DeSouza, RA; Lindler, TU; Mayorquin, FJ; Trochtenberg, DS, 2004) |
| "Mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) are usually associated with the common 3243A-->G mutation of mtDNA." | 3.72 | Late onset of stroke-like episode associated with a 3256C-->T point mutation of mitochondrial DNA. ( Danielsen, ER; Hansen, K; Jeppesen, TD; Schwartz, M; Vissing, J; Wibrand, F, 2003) |
| "We here reported the clinical course and therapeutic details of a 16-year-old girl with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) who had had five stroke-like episodes (two episodes were clinically mild, while the three subsequent episodes were severe)." | 3.72 | Beneficial effect of L-arginine for stroke-like episode in MELAS. ( Kubota, M; Momoi-Yoshida, M; Mori, M; Sakakihara, Y; Yamagata, T, 2004) |
| " Needle muscle biopsy specimens for biochemical measurement were obtained before and immediately after maximal short-term bicycle exercise test from 12 patients suffering from autosomal dominant and recessive forms of progressive external ophthalmoplegia and multiple deletions of mitochondrial DNA (adPEO, arPEO, respectively), five patients with mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) 3243 A-->G point mutation, and four patients with McArdle's disease." | 3.71 | ATP, phosphocreatine and lactate in exercising muscle in mitochondrial disease and McArdle's disease. ( Härkönen, M; Lindholm, H; Löfberg, M; Majander, A; Näveri, H; Paetau, A; Somer, H; Sovijärvi, A; Suomalainen, A, 2001) |
| "1H magnetic resonance spectroscopy (MRS) of the brain and (31)P MRS and saturation transfer of resting skeletal muscle were used to investigate intracellular metabolites and fluxes through the creatine kinase (CK) reaction in a patient with the syndrome of mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes (MELAS)." | 3.71 | Application of NMR spectroscopy to monitoring MELAS treatment: a case report. ( Hilbich, T; Kurlemann, G; Möller, HE; Schuierer, G; Wiedermann, D, 2002) |
| "Sodium dichloroacetate has been used to treat patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes (MELAS)." | 3.70 | Magnetic resonance spectroscopy: use in monitoring MELAS treatment. ( Kaplan, GP; Kingsley, PB; Lustbader, D; O'Shea, M; Pavlakis, SG; Stacpoole, PW, 1998) |
| "Clinical features of mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) resemble those of cerebral infarcts, but the pathogenesis of infarct-like lesions is not fully understood." | 3.70 | Serial diffusion-weighted imaging in MELAS. ( Imon, Y; Kajima, T; Katayama, S; Mimori, Y; Nakamura, S; Ohshita, T; Oka, M; Watanabe, C; Yamaguchi, S, 2000) |
| "To evaluate imaging findings in MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis, strokes) syndrome for the presence and location of infarctions and the presence of lactate." | 3.69 | MELAS syndrome: imaging and proton MR spectroscopic findings. ( Castillo, M; Green, C; Kwock, L, 1995) |
| "MELAS is a mitochondrial cytopathy characterized by encephalopathy with stroke-like episodes and lactic acidosis." | 3.69 | [MELAS syndrome. Clinical aspects, MRI, biochemistry and molecular genetics]. ( Bachmann, G; Damian, MS; Dorndorf, W; Reichmann, H; Schachenmayr, W; Seibel, P, 1994) |
| "Localized brain proton MR spectra were acquired from patients with different mitochondrial encephalomyopathies (myoclonus epilepsy with ragged-red fibers [MERRF], Kearns-Sayre syndrome [KSS], and mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes [MELAS])." | 3.68 | Proton MR spectroscopic characterization of differences in regional brain metabolic abnormalities in mitochondrial encephalomyopathies. ( Andermann, F; Arnold, DL; Karpati, G; Mathews, PM; Silver, K, 1993) |
| "The diagnosis of mitochondrial disorders (MDs) is occasionally difficult because patients often present with solitary, or a combination of, symptoms caused by each organ insufficiency, which may be the result of respiratory chain enzyme deficiency." | 1.42 | Growth differentiation factor 15 as a useful biomarker for mitochondrial disorders. ( Arahata, H; Fujita, Y; Fukumoto, Y; Ishii, A; Ito, M; Kakuma, T; Koga, Y; Kojima, T; Saiki, R; Tanaka, M; Yatsuga, S, 2015) |
| "High output cardiac failure is rare in MD patients and is related to myocardial abnormalities and hyperlactacidemia." | 1.40 | Refractory high output heart failure in a patient with primary mitochondrial respiratory chain disease. ( Horii, M; Kamon, D; Kawakami, R; Nakagawa, H; Nakano, T; Okayama, S; Onoue, K; Saito, Y; Sakaguchi, Y; Takemura, G; Uemura, S, 2014) |
| "Mitochondrial disorders are characterized by an accumulation of lactate and an insufficient oxygen extraction from blood during exercise." | 1.33 | Lactate increase and oxygen desaturation in mitochondrial disorders--evaluation of two diagnostic screening protocols. ( Deschauer, M; Hanisch, F; Müller, T; Muser, A; Zierz, S, 2006) |
| "The mitochondrial encephalomyopathies are chronic progressive disorders affecting predominantly the neuromuscular system." | 1.32 | Effectiveness of creatine monohydrate in mitochondrial encephalomyopathies. ( Hanefeld, FA; Hobbiebrunken, E; Komura, K; Wilichowski, EK, 2003) |
| "MELAS is a mitochondrial encephalomyopathy characterized clinically by recurrent stroke-like episodes, seizures, sensorineural deafness, dementia, hypertrophic cardiomyopathy, and short stature." | 1.31 | Oxidative phosphorylation defect in the brains of carriers of the tRNAleu(UUR) A3243G mutation in a MELAS pedigree. ( Arnold, DL; De Stefano, N; Dubeau, F; Shoubridge, EA; Zifkin, BG, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (11.11) | 18.2507 |
| 2000's | 24 (53.33) | 29.6817 |
| 2010's | 9 (20.00) | 24.3611 |
| 2020's | 7 (15.56) | 2.80 |
| Authors | Studies |
|---|---|
| Guerrero-Molina, MP | 1 |
| Morales-Conejo, M | 1 |
| Delmiro, A | 1 |
| Morán, M | 1 |
| Domínguez-González, C | 1 |
| Arranz-Canales, E | 1 |
| Ramos-González, A | 1 |
| Arenas, J | 2 |
| Martín, MA | 2 |
| González de la Aleja, J | 1 |
| Leaffer, EB | 1 |
| De Vivo, DC | 3 |
| Engelstad, K | 3 |
| Fryer, RH | 1 |
| Gu, Y | 1 |
| Shungu, DC | 3 |
| Hirano, M | 3 |
| DiMauro, S | 3 |
| Hinton, VJ | 1 |
| Kobayashi, Y | 1 |
| Karasawa, S | 1 |
| Ohashi, N | 1 |
| Yamamoto, K | 1 |
| Distelmaier, F | 1 |
| Klopstock, T | 1 |
| Kee, CK | 1 |
| Ngam, PI | 1 |
| Tan, AP | 1 |
| Ikawa, M | 2 |
| Okazawa, H | 2 |
| Yoneda, M | 2 |
| Sharma, R | 1 |
| Reinstadler, B | 1 |
| Skinner, OS | 1 |
| Stackowitz, E | 1 |
| Haller, RG | 1 |
| Clish, CB | 1 |
| Pierce, K | 1 |
| Walker, MA | 1 |
| Fryer, R | 1 |
| Oglesbee, D | 1 |
| Mao, X | 3 |
| Khatri, A | 1 |
| Mootha, VK | 1 |
| Wang, R | 1 |
| Hu, B | 1 |
| Sun, C | 1 |
| Geng, D | 1 |
| Lin, J | 1 |
| Li, Y | 1 |
| Koga, Y | 2 |
| Povalko, N | 1 |
| Inoue, E | 1 |
| Nashiki, K | 1 |
| Tanaka, M | 2 |
| Mitani, T | 1 |
| Aida, N | 1 |
| Tomiyasu, M | 1 |
| Wada, T | 1 |
| Osaka, H | 1 |
| Weiduschat, N | 1 |
| Kaufmann, P | 2 |
| Engelstad, KM | 1 |
| Hinton, V | 1 |
| De Vivo, D | 1 |
| Shungu, D | 1 |
| Nakagawa, H | 1 |
| Okayama, S | 1 |
| Kamon, D | 1 |
| Nakano, T | 1 |
| Onoue, K | 1 |
| Kawakami, R | 1 |
| Horii, M | 1 |
| Sakaguchi, Y | 1 |
| Uemura, S | 1 |
| Takemura, G | 1 |
| Saito, Y | 1 |
| Jeong, MH | 1 |
| Kim, JH | 1 |
| Seo, KS | 1 |
| Kwak, TH | 1 |
| Park, WJ | 1 |
| Yatsuga, S | 1 |
| Fujita, Y | 2 |
| Ishii, A | 1 |
| Fukumoto, Y | 1 |
| Arahata, H | 1 |
| Kakuma, T | 1 |
| Kojima, T | 1 |
| Ito, M | 1 |
| Saiki, R | 1 |
| Navajas, EV | 1 |
| Xu, K | 1 |
| Tsujikawa, T | 1 |
| Shimizu, Y | 1 |
| Uematsu, H | 1 |
| Toyooka, M | 1 |
| Kudo, T | 1 |
| Kuriyama, M | 1 |
| Kimura, H | 1 |
| Fromont, I | 1 |
| Nicoli, F | 1 |
| Valéro, R | 1 |
| Felician, O | 1 |
| Lebail, B | 1 |
| Lefur, Y | 1 |
| Mancini, J | 1 |
| Paquis-Flucklinger, V | 1 |
| Cozzone, PJ | 1 |
| Vialettes, B | 1 |
| Komura, K | 1 |
| Hobbiebrunken, E | 1 |
| Wilichowski, EK | 1 |
| Hanefeld, FA | 1 |
| Jeppesen, TD | 1 |
| Schwartz, M | 1 |
| Hansen, K | 1 |
| Danielsen, ER | 1 |
| Wibrand, F | 1 |
| Vissing, J | 1 |
| Arpa, J | 1 |
| Cruz-Martínez, A | 1 |
| Campos, Y | 1 |
| Gutiérrez-Molina, M | 1 |
| García-Rio, F | 1 |
| Pérez-Conde, C | 1 |
| Rubio, JC | 1 |
| Del Hoyo, P | 1 |
| Arpa-Fernández, A | 1 |
| Abe, K | 2 |
| Yoshimura, H | 1 |
| Tanaka, H | 1 |
| Fujita, N | 1 |
| Hikita, T | 1 |
| Sakoda, S | 1 |
| Lindholm, H | 2 |
| Löfberg, M | 2 |
| Somer, H | 2 |
| Näveri, H | 2 |
| Sovijärvi, A | 2 |
| Sano, MC | 1 |
| Jhung, S | 1 |
| Mitsis, E | 1 |
| Shanske, S | 1 |
| DeSouza, RA | 1 |
| Cardenas, RJ | 1 |
| Lindler, TU | 1 |
| De la Fuente, FA | 1 |
| Mayorquin, FJ | 1 |
| Trochtenberg, DS | 1 |
| Mori, M | 2 |
| Yamagata, T | 2 |
| Goto, T | 1 |
| Saito, S | 1 |
| Momoi, MY | 1 |
| Kubota, M | 1 |
| Sakakihara, Y | 1 |
| Momoi-Yoshida, M | 1 |
| Zhang, Y | 1 |
| Wang, ZX | 1 |
| Niu, SL | 1 |
| Xu, YF | 1 |
| Pei, P | 1 |
| Yuan, Y | 1 |
| Yang, YL | 1 |
| Qi, Y | 1 |
| Dickerson, BC | 1 |
| Holtzman, D | 1 |
| Grant, PE | 1 |
| Tian, D | 1 |
| Curtò, N | 1 |
| Tremolizzo, L | 1 |
| Mattavelli, L | 1 |
| Piatti, ML | 1 |
| Marzorati, L | 1 |
| Guerra, L | 1 |
| Grassi, MG | 1 |
| Ferrarese, C | 1 |
| Hanisch, F | 1 |
| Müller, T | 1 |
| Muser, A | 1 |
| Deschauer, M | 1 |
| Zierz, S | 1 |
| Savolainen, H | 1 |
| Feng, F | 1 |
| You, H | 1 |
| Gao, J | 1 |
| Li, XZ | 1 |
| Meng, CL | 1 |
| Sun, HY | 1 |
| Jin, ZY | 1 |
| Guo, YP | 1 |
| Sasano, N | 1 |
| So, M | 1 |
| Sobue, K | 1 |
| Sasano, H | 1 |
| Katsuya, H | 1 |
| Castillo, M | 1 |
| Kwock, L | 1 |
| Green, C | 1 |
| Damian, MS | 1 |
| Reichmann, H | 1 |
| Seibel, P | 1 |
| Bachmann, G | 1 |
| Schachenmayr, W | 1 |
| Dorndorf, W | 1 |
| Mathews, PM | 1 |
| Andermann, F | 1 |
| Silver, K | 1 |
| Karpati, G | 1 |
| Arnold, DL | 2 |
| Dunbar, DR | 1 |
| Moonie, PA | 1 |
| Zeviani, M | 1 |
| Holt, IJ | 1 |
| Pavlakis, SG | 1 |
| Kingsley, PB | 1 |
| Kaplan, GP | 1 |
| Stacpoole, PW | 1 |
| O'Shea, M | 1 |
| Lustbader, D | 1 |
| Dubeau, F | 1 |
| De Stefano, N | 1 |
| Zifkin, BG | 1 |
| Shoubridge, EA | 1 |
| Rubio-Gozalbo, ME | 1 |
| Sengers, RC | 1 |
| Trijbels, JM | 1 |
| Doesburg, WH | 1 |
| Janssen, AJ | 1 |
| Verbeek, AL | 1 |
| Smeitink, JA | 1 |
| Ohshita, T | 1 |
| Oka, M | 1 |
| Imon, Y | 1 |
| Watanabe, C | 1 |
| Katayama, S | 1 |
| Yamaguchi, S | 1 |
| Kajima, T | 1 |
| Mimori, Y | 1 |
| Nakamura, S | 1 |
| Majander, A | 1 |
| Suomalainen, A | 1 |
| Paetau, A | 1 |
| Härkönen, M | 1 |
| Strachan, J | 1 |
| McLellan, A | 1 |
| Kirkpatrick, M | 1 |
| Hume, R | 1 |
| Mechan, D | 1 |
| Möller, HE | 1 |
| Wiedermann, D | 1 |
| Kurlemann, G | 1 |
| Hilbich, T | 1 |
| Schuierer, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Mitochondrial Encephalomyopathies and Mental Retardation: Investigations of Clinical Syndromes Associated With MtDNA Point Mutations[NCT01532791] | 300 participants (Anticipated) | Observational | 2004-07-31 | Recruiting | |||
| GDF-15 as a Biomarker for Mitochondrial Disease[NCT02745938] | 97 participants (Actual) | Observational | 2016-06-30 | Completed | |||
| Nutritional Assessment in Patients Affected by Mitochondrial Cytopathy[NCT02375438] | 26 participants (Actual) | Observational | 2014-12-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for lactic acid and MELAS Syndrome
| Article | Year |
|---|---|
Neuroimaging in mitochondrial disease.
Topics: Brain; Humans; Lactic Acid; Leigh Disease; Magnetic Resonance Imaging; MELAS Syndrome; Mitochondrial | 2023 |
Molecular imaging for mitochondrial metabolism and oxidative stress in mitochondrial diseases and neurodegenerative disorders.
Topics: Acidosis, Lactic; Brain Diseases; Electron Transport; Fatty Acids; Glucose; Humans; Lactic Acid; Mag | 2021 |
4 trials available for lactic acid and MELAS Syndrome
| Article | Year |
|---|---|
Circulating markers of NADH-reductive stress correlate with mitochondrial disease severity.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alanine; Biomarkers; Child; Child, Preschool; Female; Gr | 2021 |
Cerebral lactic acidosis correlates with neurological impairment in MELAS.
Topics: Acidosis, Lactic; Adult; Blood Glucose; Cerebral Ventricles; Chronic Disease; DNA Mutational Analysi | 2004 |
Dichloroacetate treatment for mitochondrial cytopathy: long-term effects in MELAS.
Topics: Abdominal Pain; Administration, Oral; Adolescent; Chemical and Drug Induced Liver Injury; Child; Dic | 2004 |
Dichloroacetate causes toxic neuropathy in MELAS: a randomized, controlled clinical trial.
Topics: Acidosis; Adolescent; Adult; Child; Cross-Over Studies; Dichloroacetic Acid; Double-Blind Method; Hu | 2006 |
39 other studies available for lactic acid and MELAS Syndrome
| Article | Year |
|---|---|
Elevated glutamate and decreased glutamine levels in the cerebrospinal fluid of patients with MELAS syndrome.
Topics: Adult; Alanine; Case-Control Studies; DNA, Mitochondrial; Female; Glutamic Acid; Glutamine; Humans; | 2022 |
Visual memory failure presages conversion to MELAS phenotype.
Topics: Brain; Humans; Lactic Acid; MELAS Syndrome; Phenotype; Stroke | 2022 |
Disseminated stroke-like episodes lesions in MELAS are partially reversible with lactate disappearance.
Topics: Humans; Lactic Acid; Magnetic Resonance Spectroscopy; MELAS Syndrome; Stroke | 2023 |
An Unusual Cause of Stroke-Like Symptoms in an Elderly Patient.
Topics: Aphasia; Cerebral Angiography; Diagnosis, Differential; Electroencephalography; Humans; Lactic Acid; | 2019 |
Metabolic abnormality in acute stroke-like lesion and its relationship with focal cerebral blood flow in patients with MELAS: Evidence from proton MR spectroscopy and arterial spin labeling.
Topics: Adolescent; Adult; Aspartic Acid; Brain; Case-Control Studies; Choline; Creatine; Female; Glutamic A | 2021 |
Biomarkers and clinical rating scales for sodium pyruvate therapy in patients with mitochondrial disease.
Topics: Acidosis, Lactic; Adolescent; Adult; Biomarkers; Female; Fibroblast Growth Factors; Growth Different | 2019 |
Transient ischemic attack-like episodes without stroke-like lesions in MELAS.
Topics: Biomarkers; Brain; Child; Diagnosis, Differential; Female; Humans; Ischemic Attack, Transient; Lacti | 2013 |
Cerebral metabolic abnormalities in A3243G mitochondrial DNA mutation carriers.
Topics: Acidosis, Lactic; Adult; Aged; Aspartic Acid; Cerebral Cortex; Choline; Creatine; DNA, Mitochondrial | 2014 |
Refractory high output heart failure in a patient with primary mitochondrial respiratory chain disease.
Topics: Adult; Cardiac Output, High; Cardiomyopathies; Heart Failure; Hemodiafiltration; Humans; Lactic Acid | 2014 |
β-Lapachone attenuates mitochondrial dysfunction in MELAS cybrid cells.
Topics: DNA, Mitochondrial; Energy Metabolism; Gene Expression Regulation; HeLa Cells; Humans; Lactic Acid; | 2014 |
Growth differentiation factor 15 as a useful biomarker for mitochondrial disorders.
Topics: Adolescent; Adult; Biomarkers; Child; Creatine Kinase; Female; Fibroblast Growth Factors; Growth Dif | 2015 |
Spectral-domain optical coherence tomography in mitochondrial encephalopathy, lactic acidosis, and strokelike episodes.
Topics: Adult; Atrophy; DNA, Mitochondrial; Electrooculography; Electroretinography; Female; Humans; Lactic | 2015 |
Pathophysiologic evaluation of MELAS strokes by serially quantified MRS and CASL perfusion images.
Topics: Adult; Aspartic Acid; Brain; Cerebrovascular Circulation; Child; Diagnostic Imaging; Female; Humans; | 2010 |
Brain anomalies in maternally inherited diabetes and deafness syndrome.
Topics: Adult; Aged; Brain; Cerebellar Ataxia; Cognition Disorders; Deafness; Diabetes Mellitus; Diabetes Me | 2009 |
Effectiveness of creatine monohydrate in mitochondrial encephalomyopathies.
Topics: Adolescent; Adult; Child; Creatine; Exercise Test; Female; Humans; Lactic Acid; Male; MELAS Syndrome | 2003 |
Late onset of stroke-like episode associated with a 3256C-->T point mutation of mitochondrial DNA.
Topics: Adult; Age of Onset; Cerebral Cortex; DNA, Mitochondrial; Exercise Tolerance; Female; Humans; Lactic | 2003 |
Prevalence and progression of mitochondrial diseases: a study of 50 patients.
Topics: Adolescent; Adult; Age of Onset; Aged; Disease Progression; DNA, Mitochondrial; Electromyography; Ep | 2003 |
Comparison of conventional and diffusion-weighted MRI and proton MR spectroscopy in patients with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like events.
Topics: Adolescent; Adult; Cerebral Cortex; Diagnosis, Differential; Diffusion Magnetic Resonance Imaging; D | 2004 |
Abnormal blood lactate accumulation after exercise in patients with multiple mitochondrial DNA deletions and minor muscular symptoms.
Topics: Adult; Case-Control Studies; DNA, Mitochondrial; Exercise; Female; Gene Deletion; Glycogen Storage D | 2004 |
Mitochondrial encephalomyopathy with lactic acidosis and strokelike episodes (MELAS): a mitochondrial disorder presents as fibromyalgia.
Topics: Aged; Diagnosis, Differential; Female; Fibromyalgia; Humans; Lactic Acid; MELAS Syndrome; Muscle, Sk | 2004 |
Beneficial effect of L-arginine for stroke-like episode in MELAS.
Topics: Adolescent; Arginine; Brain; Brain Ischemia; Drug Therapy, Combination; Energy Metabolism; Female; G | 2004 |
Cerebral lactic acidosis correlates with neurological impairment in MELAS.
Topics: Acidosis, Lactic; Astrocytes; Biological Transport; Brain Damage, Chronic; Cerebral Ventricles; Huma | 2004 |
[Phenotype heterogeneity associated with mitochondrial DNA A3243G mutation].
Topics: Adolescent; Adult; Child; Child, Preschool; DNA, Mitochondrial; Female; Humans; Infant; Kearns-Sayre | 2005 |
Case records of the Massachusetts General Hospital. Case 36-2005. A 61-year-old woman with seizure, disturbed gait, and altered mental status.
Topics: Aphasia; Biopsy; Brain; Confusion; Diagnosis, Differential; Fatal Outcome; Female; Gait Disorders, N | 2005 |
A case of Melas (A3243G) on chronic dichloroacetate treatment.
Topics: Adolescent; Brain Ischemia; Dichloroacetic Acid; Disease Progression; DNA Mutational Analysis; Domin | 2006 |
Lactate increase and oxygen desaturation in mitochondrial disorders--evaluation of two diagnostic screening protocols.
Topics: Adolescent; Adult; Aged; Exercise; Exercise Test; Female; Forearm; Gene Deletion; Hand Strength; Hum | 2006 |
Evaluation of mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes with magnetic resonance imaging and proton magnetic resonance spectroscopy.
Topics: Adolescent; Adult; Basal Ganglia; Cerebral Cortex; Child; Female; Humans; Lactic Acid; Magnetic Reso | 2006 |
Anesthetic management of a patient with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) during laparotomy.
Topics: Amides; Anesthesia; Anesthesia, Epidural; Anesthetics, Intravenous; Anesthetics, Local; Blood Gas An | 2007 |
MELAS syndrome: imaging and proton MR spectroscopic findings.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Brain; Brain Chemistry; Child, Preschool; Female; Humans | 1995 |
[MELAS syndrome. Clinical aspects, MRI, biochemistry and molecular genetics].
Topics: Adolescent; Adult; Atrophy; Biopsy; Brain; Female; Follow-Up Studies; Humans; Lactates; Lactic Acid; | 1994 |
Proton MR spectroscopic characterization of differences in regional brain metabolic abnormalities in mitochondrial encephalomyopathies.
Topics: Aspartic Acid; Brain; Choline; Creatine; Humans; Kearns-Sayre Syndrome; Lactates; Lactic Acid; Magne | 1993 |
Complex I deficiency is associated with 3243G:C mitochondrial DNA in osteosarcoma cell cybrids.
Topics: Cell Fusion; DNA, Mitochondrial; Electron Transport Complex IV; Humans; Hybrid Cells; Lactates; Lact | 1996 |
Magnetic resonance spectroscopy: use in monitoring MELAS treatment.
Topics: Adult; Brain; Cerebrovascular Disorders; Creatine; Dichloroacetic Acid; Female; Humans; Lactic Acid; | 1998 |
Oxidative phosphorylation defect in the brains of carriers of the tRNAleu(UUR) A3243G mutation in a MELAS pedigree.
Topics: Adult; Aged; Brain; DNA, Mitochondrial; Female; Heterozygote; Humans; Lactic Acid; Magnetic Resonanc | 2000 |
A prognostic index as diagnostic strategy in children suspected of mitochondriocytopathy.
Topics: Adolescent; Adult; Biopsy; Child; Child, Preschool; DNA, Mitochondrial; Electron Transport; Female; | 2000 |
Serial diffusion-weighted imaging in MELAS.
Topics: Adult; Atrophy; Brain; DNA, Mitochondrial; Echo-Planar Imaging; Female; Humans; Lactic Acid; Magneti | 2000 |
ATP, phosphocreatine and lactate in exercising muscle in mitochondrial disease and McArdle's disease.
Topics: Adenosine Triphosphate; Adult; Aged; DNA, Mitochondrial; Electron Transport; Enzymes; Exercise; Exer | 2001 |
Ketoacidosis: an unusual presentation of MELAS.
Topics: Blood Glucose; C-Reactive Protein; Cerebral Infarction; Child; Creatinine; Humans; Ketosis; Lactic A | 2001 |
Application of NMR spectroscopy to monitoring MELAS treatment: a case report.
Topics: Adolescent; Aspartic Acid; Brain; Creatine; Female; Glutamic Acid; Humans; Inositol; Lactic Acid; Ma | 2002 |