Page last updated: 2024-10-17

lactic acid and Lung Neoplasms

lactic acid has been researched along with Lung Neoplasms in 163 studies

Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.

Lung Neoplasms: Tumors or cancer of the LUNG.

Research Excerpts

ExcerptRelevanceReference
" l-lactic acidosis, a common condition comprising high l-lactate concentration and acidic pH in the tumor microenvironment, has been known to induce tumor metastasis and drug resistance."8.12l-lactic acidosis confers insensitivity to PKC inhibitors by competing for uptake via monocarboxylate transporters. ( Chen, CH; Chen, CJ; Cheng, FJ; Chiou, JY; Huang, WC; Liu, YC; Nguyen, KTL; Shen, YC; Tang, CH; Tu, CY, 2022)
" Mutations in the tyrosine kinase epidermal growth factor receptor (EGFR) induce oncogenic addiction in lung adenocarcinoma (LAD)."7.80Epidermal growth factor receptor (EGFR) signaling regulates global metabolic pathways in EGFR-mutated lung adenocarcinoma. ( Esumi, H; Makinoshima, H; Matsumoto, S; Owada, S; Takita, M; Tsuchihara, K; Yagishita, A, 2014)
"Urethane is a recognized genotoxic carcinogen in fermented foods and beverages."5.43Lasting glycolytic stress governs susceptibility to urethane-induced lung carcinogenesis in vivo and in vitro. ( Cao, N; Deng, J; Du, G; Duan, Y; Geng, S; Guo, Z; Lin, H; Ma, X; Meng, M; Zheng, Y, 2016)
"Although pulmonary dosing of large porous particles has been shown to sustain drug delivery for a few days, there are no reports on safety or long term delivery."5.39Supercritical fluid technology based large porous celecoxib-PLGA microparticles do not induce pulmonary fibrosis and sustain drug delivery and efficacy for several weeks following a single dose. ( Dhanda, DS; Kompella, UB; Mirvish, SS; Tyagi, P, 2013)
"The melanoma cell metastasis to lungs was prevented by intravenous co-injection of B16BL6 melanoma cells with 1."5.33The effect of poly (aspartic acid-co-lactic acid) nanospheres on the lung metastasis of B16BL6 melanoma cells by intravenous administration. ( Hara, K; Huang, CC; Kawashima, Y; Mimura, H; Miwa, N; Tsujimoto, H, 2006)
" l-lactic acidosis, a common condition comprising high l-lactate concentration and acidic pH in the tumor microenvironment, has been known to induce tumor metastasis and drug resistance."4.12l-lactic acidosis confers insensitivity to PKC inhibitors by competing for uptake via monocarboxylate transporters. ( Chen, CH; Chen, CJ; Cheng, FJ; Chiou, JY; Huang, WC; Liu, YC; Nguyen, KTL; Shen, YC; Tang, CH; Tu, CY, 2022)
" Mutations in the tyrosine kinase epidermal growth factor receptor (EGFR) induce oncogenic addiction in lung adenocarcinoma (LAD)."3.80Epidermal growth factor receptor (EGFR) signaling regulates global metabolic pathways in EGFR-mutated lung adenocarcinoma. ( Esumi, H; Makinoshima, H; Matsumoto, S; Owada, S; Takita, M; Tsuchihara, K; Yagishita, A, 2014)
" The present study demonstrates that chitosan (CS)-modified PLGA NSs (CS-PLGA NSs) are preferentially taken up by human lung adenocarcinoma cells (A549)."3.75Improved cellular uptake of chitosan-modified PLGA nanospheres by A549 cells. ( Hirashima, N; Kawashima, Y; Sakai, T; Tahara, K; Takeuchi, H; Yamamoto, H, 2009)
"The aim of this study was to examine the effect of increased content of 45S5 Bioglass (0-40 wt%) in poly(dl-lactic acid) (PDLLA) porous foams on the behaviour of MG-63 (human osteosarcoma cell line) and A549 cells (human lung carcinoma cell line)."3.72PDLLA/Bioglass composites for soft-tissue and hard-tissue engineering: an in vitro cell biology assessment. ( Blaker, JJ; Boccaccini, AR; Hench, LL; Maquet, V; Verrier, S, 2004)
"Targeted-therapy failure in treating nonsmall cell lung cancer (NSCLC) frequently occurs because of the emergence of drug resistance and genetic mutations."2.72Potential therapeutics using tumor-secreted lactate in nonsmall cell lung cancer. ( Hsieh, CC; Kempson, IM; Liao, ZX; Tseng, SJ; Yang, PC, 2021)
"Radiation-induced lung injury (RILI) is a consequence of therapeutic thoracic irradiation (TR) for many cancers, and there are no FDA-approved curative strategies."1.91Exhaled breath condensate identifies metabolic dysregulation in patients with radiation-induced lung injury. ( Allegood, JC; Camus, SV; Cowart, LA; Freeberg, MAT; Jackson, PD; Liu, J; Pierre-Louis Odoom, J; Sanchez Rosado, RM; Silvey, S; Sime, PJ; Szomju, BB; Thatcher, TH; Toft, R; Weiss, E, 2023)
"Aspirin has been reported to promote apoptosis, inhibit proliferation, stemness, angiogenesis, cancer-associated inflammation and migration in NSCLC."1.72Aspirin blocks AMPK/SIRT3-mediated glycolysis to inhibit NSCLC cell proliferation. ( Li, G; Ma, Y; Ren, G; Wang, X; Zheng, Z, 2022)
"Patients with high-risk non-metastatic renal cell carcinoma (RCC) are at risk of metastatic relapse following nephrectomy."1.72Cabozantinib-Loaded PLGA Nanoparticles: A Potential Adjuvant Strategy for Surgically Resected High-Risk Non-Metastatic Renal Cell Carcinoma. ( Choy, YB; Kim, CR; Kim, SN; Lee, HW; Park, CG; Park, DH; Park, W; Seo, HS; Seo, SI; Yeom, SY, 2022)
"However, its role in breast cancer cell glucose metabolism was unclear."1.62Anti-Warburg effect by targeting HRD1-PFKP pathway may inhibit breast cancer progression. ( Fan, Y; Jin, F; Liang, X; Song, T; Su, D; Wang, J; Wang, Y; Xu, Y, 2021)
"Isovitexin (IVT) is a well-known flavone C-glycoside found in many plants and has attracted wide attention due to its obvious antitumor and antioxidant effects."1.62Isovitexin potentiated the antitumor activity of cisplatin by inhibiting the glucose metabolism of lung cancer cells and reduced cisplatin-induced immunotoxicity in mice. ( Chen, RL; He, JQ; Huang, P; Sun, CH; Wang, Z; Yu, CH; Yu, WY; Zhang, HH, 2021)
"Lung cancer is the leading cause of cancer death worldwide, and the carcinogens in tobacco smoke play a role in its progression and metastasis."1.62Cigarette smoke extract reduces FOXO3a promoting tumor progression and cell migration in lung cancer. ( Buscetta, M; Cipollina, C; Di Vincenzo, S; Ferraro, M; Pace, E; Sangiorgi, C, 2021)
"In the treatment of lung adenocarcinoma, targeting PFKFB3 would be a promising therapeutic strategy."1.48Expression of PFKFB3 and Ki67 in lung adenocarcinomas and targeting PFKFB3 as a therapeutic strategy. ( Ke, H; Li, X; Liu, J; Liu, Y; Qian, L; Tian, W; Yao, C; Zhang, J, 2018)
"Salinomycin sodium (SS) is an antibacterial therapeutic agent that exerts potent activity against CICs in various types of cancer, including lung cancer."1.48Promoted delivery of salinomycin sodium to lung cancer cells by dual targeting PLGA hybrid nanoparticles. ( Chen, H; Peng, Q; Sun, J; Zhou, J, 2018)
"Curcumin and Fe3O4 were encapsulated inside the PLGA-PEG co-polymer."1.46The Effects of Nanoencapsulated Curcumin-Fe3O4 on Proliferation and hTERT Gene Expression in Lung Cancer Cells. ( Akbarzadeh, A; Dariushnejad, H; Pilehvar-Soltanahmadi, Y; Sadeghzadeh, H; Sanjarian, F; Zarghami, N, 2017)
"Curcumin is a safe and efficient anticancer agent in this context, but its applications in cancer therapy are limited because of its hydrophobic structure and low solubility in water."1.43A comparison between PLGA-PEG and NIPAAm-MAA nanocarriers in curcumin delivery for hTERT silencing in lung cancer cell line. ( Badrzadeh, F; Roointan, A; Sharifi-Rad, J; Sharifi-Rad, M, 2016)
"Urethane is a recognized genotoxic carcinogen in fermented foods and beverages."1.43Lasting glycolytic stress governs susceptibility to urethane-induced lung carcinogenesis in vivo and in vitro. ( Cao, N; Deng, J; Du, G; Duan, Y; Geng, S; Guo, Z; Lin, H; Ma, X; Meng, M; Zheng, Y, 2016)
"Lung cancer is the major cause of cancer related lethality worldwide, and metastasis to distant organs is the pivotal cause of death for the vast majority of lung cancer patients."1.42Active targeting docetaxel-PLA nanoparticles eradicate circulating lung cancer stem-like cells and inhibit liver metastasis. ( Hou, C; Jiang, Y; Liu, Y; Sun, B; Yang, N; Zhang, H; Zheng, J; Zuo, P, 2015)
"Biphasic malignant pleural mesothelioma (MPM) is the second most common histotype of MPM."1.42Intracellular lactate-mediated induction of estrogen receptor beta (ERβ) in biphasic malignant pleural mesothelioma cells. ( Cilli, M; Daga, A; Manente, AG; Moro, L; Nilsson, S; Pinton, G; Rinaldi, M; Zonca, S, 2015)
"Radiotherapy is a key component of cancer treatment."1.42Improving DNA double-strand repair inhibitor KU55933 therapeutic index in cancer radiotherapy using nanoparticle drug delivery. ( Caster, JM; Foote, M; Hyder, SN; Lara, H; Saripalli, S; Sethi, M; Tian, X; Wagner, KT; Wang, AZ; Wang, E; Zhang, L, 2015)
"Cisplatin-resistant lung and ovarian cancer cell lines were used to evaluate the efficacy of metabolic inhibitors for selectively targeting cisplatin-resistant cells under varying oxygen conditions."1.40Targeting cisplatin-resistant human tumor cells with metabolic inhibitors. ( Brenneman, R; Kurtoglu, M; Lampidis, TJ; Liu, H; Sullivan, EJ, 2014)
"Although pulmonary dosing of large porous particles has been shown to sustain drug delivery for a few days, there are no reports on safety or long term delivery."1.39Supercritical fluid technology based large porous celecoxib-PLGA microparticles do not induce pulmonary fibrosis and sustain drug delivery and efficacy for several weeks following a single dose. ( Dhanda, DS; Kompella, UB; Mirvish, SS; Tyagi, P, 2013)
"As in ovarian cancer cells, increased metabolic activity and glucose concentration has been linked to aggressiveness of cancer."1.39Therapeutic role of EF24 targeting glucose transporter 1-mediated metabolism and metastasis in ovarian cancer cells. ( Ben, W; Dong, L; Guan, Y; Huang, Y; Lu, M; Ning, N; Wang, Y; Yang, Y; Yuan, J; Zhang, D, 2013)
" Furthermore, the synergism observed between TRAIL and doxorubicin suggests that the doxorubicin dosage could be substantially reduced and its side effects minimized."1.39Doxorubicin-loaded porous PLGA microparticles with surface attached TRAIL for the inhalation treatment of metastatic lung cancer. ( Byeon, HJ; Kim, I; Kim, TH; Lee, ES; Lee, KC; Oh, KT; Shin, BS; Youn, YS, 2013)
") Thus, overall results suggest that nano-encapsulation of PD (NPD) increases drug bioavailability and thereby has a better chemo-preventive action against lung cancer in vivo and on A549 cells in vitro than that of PD."1.38Poly (lactide-co-glycolide) encapsulated extract of Phytolacca decandra demonstrates better intervention against induced lung adenocarcinoma in mice and on A549 cells. ( Bhadra, K; Das, J; Das, S; Khuda-Bukhsh, AR; Samadder, A, 2012)
"As a means of treating lymphatic metastasis from lung cancer, the pharmacokinetics and therapeutic effects of an intrapleural (ipl) implantable drug delivery system consisting of a gelatin sponge impregnated with polylactide-co-glycolide paclitaxel (PLGA-PTX) microspheres were studied."1.35Translymphatic chemotherapy by intrapleural placement of gelatin sponge containing biodegradable Paclitaxel colloids controls lymphatic metastasis in lung cancer. ( Johnston, MR; Kwong, E; Liu, J; Meisner, D; Wu, XY, 2009)
"In mice injected with B16 melanoma cells, the sustained IL-1Ra delivery from biodegradable microspheres inhibited tumor growth and significantly prolonged mice survival."1.34Sustained delivery of IL-1 Ra from biodegradable microspheres reduces the number of murine B16 melanoma lung metastases. ( Apte, RN; Cohen, S; Dinarello, CA; Lavi, G; Voronov, E, 2007)
"The melanoma cell metastasis to lungs was prevented by intravenous co-injection of B16BL6 melanoma cells with 1."1.33The effect of poly (aspartic acid-co-lactic acid) nanospheres on the lung metastasis of B16BL6 melanoma cells by intravenous administration. ( Hara, K; Huang, CC; Kawashima, Y; Mimura, H; Miwa, N; Tsujimoto, H, 2006)
"Clofazimine was shown to have a direct cytotoxic effect in vitro with an ID50 of 10."1.29Clofazimine alters the energy metabolism and inhibits the growth rate of a human lung-cancer cell line in vitro and in vivo. ( Fearon, KC; Plumb, JA; Sri-Pathmanathan, RM, 1994)
" Pharmacokinetic analysis showed that the initial tumor uptake of dFdC was flow limited, and a significant inverse correlation between the geometric FR and initial drug uptake was found."1.29Intratumor pharmacokinetics, flow resistance, and metabolism during gemcitabine infusion in ex vivo perfused human small cell lung cancer. ( Brown, TJ; Jain, RK; Kristjansen, PE; Shipley, LA, 1996)
"For the treatment of malignant pleural effusions, we prepared doxorubicin hydrochloride (Adriamycin)-containing poly(L-lactic acid) microspheres (ADR-MS)."1.28Treatment of malignant pleural effusions with doxorubicin hydrochloride-containing poly(L-lactic acid) microspheres. ( Hitomi, S; Ikada, Y; Ike, O; Shimizu, Y; Wada, R, 1991)
"A new dosage form of cisplatinum (CDDP), lactic acid oligomer microspheres incorporating cisplatinum (CDDP-ms), is designed to slowly release 70% of contained CDDP."1.28[Intracavitary microspheres incorporating cisplatinum in the treatment of malignant effusions--clinical trials]. ( Hagiwara, A; Ito, M; Iwamoto, A; Lee, M; Sasabe, T; Takahashi, T; Taniguchi, H; Wada, R; Yamaguchi, T; Yoneyama, C, 1990)

Research

Studies (163)

TimeframeStudies, this research(%)All Research%
pre-19907 (4.29)18.7374
1990's7 (4.29)18.2507
2000's20 (12.27)29.6817
2010's92 (56.44)24.3611
2020's37 (22.70)2.80

Authors

AuthorsStudies
Nguyen, KTL1
Chiou, JY1
Liu, YC1
Cheng, FJ1
Shen, YC1
Chen, CJ1
Tang, CH1
Huang, WC1
Chen, CH1
Tu, CY1
Xie, M1
Fu, XG1
Jiang, K2
Chen, W1
Li, Q5
Hou, R1
Liang, H2
Zhang, Y8
Yang, Y3
Gencer, A1
Baysal, I1
Nemutlu, E1
Yabanoglu-Ciftci, S1
Arica, B1
Ren, G2
Ma, Y1
Wang, X3
Zheng, Z1
Li, G1
Zhao, F1
Wang, Z5
Li, Z2
Liu, S1
Li, S4
Lee, HW1
Seo, HS1
Yeom, SY1
Kim, SN1
Kim, CR1
Park, DH1
Park, W1
Choy, YB1
Park, CG1
Seo, SI1
Shang, S2
Wang, MZ2
Xing, Z2
He, N2
Li, J3
Wu, Z5
Chen, G1
Zhu, X1
Zhang, R2
Wu, W1
Zhu, Y2
Ma, L1
Yu, H1
Hao, D1
Li, Y1
Shi, J2
Jiang, J2
Liu, B1
Zhang, J9
Meng, X1
Xie, SM1
Liu, F2
Chen, H2
Yao, D1
Li, M2
Guo, M1
Shen, H2
Zhang, X2
Xing, L1
Liu, X2
Qin, H1
Zhang, L8
Jia, C1
Chao, Z1
Qin, X1
Zhang, H2
Chen, C3
Guo, Z2
Hu, L1
Wang, Q1
Wang, Y7
Liu, XP1
Hu, W1
Silva, A1
Cerqueira, MC1
Rosa, B1
Sobral, C1
Pinto-Ribeiro, F1
Costa, MF1
Baltazar, F2
Afonso, J1
Chen, WJ1
Huang, SY1
Chen, YW1
Liu, YF1
Huang, RS1
Pierre-Louis Odoom, J1
Freeberg, MAT1
Camus, SV1
Toft, R1
Szomju, BB1
Sanchez Rosado, RM1
Jackson, PD1
Allegood, JC1
Silvey, S1
Liu, J3
Cowart, LA1
Weiss, E1
Thatcher, TH1
Sime, PJ1
Chen, Z2
Song, Y1
Li, P1
Gao, W1
Seelbinder, B1
Lohinai, Z1
Vazquez-Uribe, R1
Brunke, S1
Chen, X5
Mirhakkak, M1
Lopez-Escalera, S1
Dome, B1
Megyesfalvi, Z1
Berta, J1
Galffy, G1
Dulka, E1
Wellejus, A1
Weiss, GJ1
Bauer, M1
Hube, B1
Sommer, MOA1
Panagiotou, G1
Tong, Z1
Tong, C1
Wu, L1
Xu, L1
Li, K1
Xu, F1
Liang, S1
Kong, Y1
Chen, B1
Wang, M2
He, T1
Meng, D1
Lv, W1
Ye, J1
Cheng, L1
Hu, J2
Li, W2
Huang, X1
Feng, D1
Zou, X1
Zhou, Y1
Xie, Q1
Zhu, Z2
He, Y2
Zhang, Z4
Luo, J2
Peng, T1
Cheng, F1
Gao, J1
Cao, Y4
Wei, H4
Singh, S1
Pandey, S1
Chawla, AS1
Bhatt, AN1
Roy, BG1
Saluja, D1
Dwarakanath, BS1
Huang, T1
Zhou, X3
Mao, X1
Yu, C1
Yang, J4
Su, T1
Malviya, N1
Sonkar, C1
Ganguly, R1
Bhattacherjee, D1
Bhabak, KP1
Mukhopadhyay, S1
Yuan, Y2
Sun, L1
Chen, J2
Jia, M1
Zou, Y1
Sa, H1
Cai, Y2
Xu, Y2
Sun, C1
Guo, Y2
Li, H4
Ma, K1
Murray, PJ1
Hu, M1
Zhao, Y2
Tang, Q1
Feng, Z1
Ni, J1
Flint, LE1
Hamm, G1
Ready, JD1
Ling, S1
Duckett, CJ1
Cross, NA1
Cole, LM1
Smith, DP1
Goodwin, RJA1
Clench, MR1
Chen, S2
Yang, X2
Xie, B1
Guo, J4
Wang, C4
Wang, K1
Huang, W1
Chen, R1
Lin, P1
Zhang, T1
Ni, YF1
Wu, J3
Sun, XX1
Geng, JJ1
Zhu, YM1
Nan, G1
Zhang, W2
Zhu, P1
Bian, H1
Chen, ZN1
Fan, Y1
Wang, J3
Song, T1
Liang, X1
Jin, F2
Su, D1
Chen, RL1
Huang, P2
Sun, CH1
Yu, WY1
Zhang, HH1
Yu, CH1
He, JQ1
Di Vincenzo, S1
Sangiorgi, C1
Ferraro, M1
Buscetta, M1
Cipollina, C1
Pace, E1
Yuan, Q2
Cao, X2
Cao, J2
Xia, L1
Xiong, B1
Chen, Y3
Liu, Y5
Hu, X1
Han, H4
Ghergurovich, JM1
Lang, JD1
Levin, MK1
Briones, N1
Facista, SJ1
Mueller, C1
Cowan, AJ1
McBride, MJ1
Rodriguez, ESR1
Killian, A1
Dao, T1
Lamont, J1
Barron, A1
Su, X1
Hendricks, WPD1
Espina, V1
Von Hoff, DD1
O'Shaughnessy, J1
Rabinowitz, JD1
Chang, H1
Xu, Q1
Ma, H1
Liao, ZX2
Kempson, IM2
Hsieh, CC1
Tseng, SJ2
Yang, PC2
Ziaei, E1
Emami, J1
Rezazadeh, M1
Kazemi, M1
Feng, J1
Yang, H1
Zhu, B2
Yang, M2
Cao, W1
Wang, L1
Faubert, B1
Li, KY1
Cai, L1
Hensley, CT1
Kim, J1
Zacharias, LG1
Yang, C2
Do, QN1
Doucette, S1
Burguete, D1
Huet, G1
Wigal, T1
Butt, Y1
Ni, M1
Torrealba, J1
Oliver, D1
Lenkinski, RE1
Malloy, CR1
Wachsmann, JW1
Young, JD1
Kernstine, K1
DeBerardinis, RJ2
Khan, MN1
Haggag, YA1
Lane, ME1
McCarron, PA1
Tambuwala, MM1
Li, X2
Qian, L1
Ke, H1
Yao, C1
Tian, W1
Caronni, N1
Simoncello, F1
Stafetta, F1
Guarnaccia, C1
Ruiz-Moreno, JS1
Opitz, B1
Galli, T1
Proux-Gillardeaux, V1
Benvenuti, F1
Patel, J1
Amrutiya, J1
Bhatt, P1
Javia, A1
Jain, M1
Misra, A1
Jiang, W1
Wang, H3
Cui, Y1
Lei, Y1
Xu, D1
Jiang, N1
Sun, Y1
Ke, Z1
Ignjatović, NL1
Penov-Gaši, KM1
Ajduković, JJ1
Kojić, VV1
Marković, SB1
Uskoković, DP1
Wang, W4
Pan, G1
Yi, Q1
Zhong, W1
Yan, D1
Zhou, J1
Sun, J1
Peng, Q1
Apicella, M1
Giannoni, E1
Fiore, S1
Ferrari, KJ1
Fernández-Pérez, D1
Isella, C1
Granchi, C1
Minutolo, F1
Sottile, A1
Comoglio, PM1
Medico, E1
Pietrantonio, F1
Volante, M1
Pasini, D1
Chiarugi, P1
Giordano, S1
Corso, S1
Huang, KY1
Li, HJ1
Fa, YC1
Ho, YC1
Liu, N1
Kuang, D1
Xu, S1
Duan, Y2
Xia, Y1
Wei, Z1
Xie, X1
Yin, B1
Chen, F1
Luo, S1
Liu, H3
Gong, F1
Tang, ZH1
Cheng, X2
Laurence, A1
Wang, G2
Yang, XP1
Updegraff, BL1
Padanad, MS1
Chen, PH1
Sudderth, J1
Rodriguez-Tirado, C1
Girard, L1
Minna, JD1
Mishra, P1
O'Donnell, KA1
Yu, B1
Wu, Y1
Huang, B1
Liu, CS1
Dhanda, DS1
Tyagi, P1
Mirvish, SS1
Kompella, UB1
Elsaid Ali, AA1
Taher, M1
Mohamed, F1
Webster, TJ3
Kim, I2
Byeon, HJ2
Kim, TH2
Lee, ES2
Oh, KT2
Shin, BS2
Lee, KC2
Youn, YS2
Rizwan, A1
Serganova, I1
Khanin, R1
Karabeber, H1
Ni, X1
Thakur, S1
Zakian, KL1
Blasberg, R1
Koutcher, JA1
Karra, N1
Nassar, T1
Ripin, AN1
Schwob, O1
Borlak, J1
Benita, S1
Guo, FC1
Wang, LQ1
Wang, YS1
Zhang, D1
Dong, L1
Huang, Y1
Yuan, J1
Ben, W1
Ning, N1
Lu, M1
Guan, Y1
Polański, R1
Hodgkinson, CL1
Fusi, A1
Nonaka, D1
Priest, L1
Kelly, P1
Trapani, F1
Bishop, PW1
White, A1
Critchlow, SE1
Smith, PD1
Blackhall, F1
Dive, C1
Morrow, CJ1
Rodrigues, TB1
Serrao, EM1
Kennedy, BW1
Hu, DE1
Kettunen, MI1
Brindle, KM1
Sullivan, EJ1
Kurtoglu, M1
Brenneman, R1
Lampidis, TJ1
Zhao, T1
Morinibu, A1
Kobayashi, M1
Shinomiya, K1
Itasaka, S1
Yoshimura, M1
Guo, G1
Hiraoka, M1
Harada, H1
El Sayed, SM1
Mohamed, WG1
Seddik, MA1
Ahmed, AS1
Mahmoud, AG1
Amer, WH1
Helmy Nabo, MM1
Hamed, AR1
Ahmed, NS1
Abd-Allah, AA1
Yang, Z2
Sun, R1
Mo, Z1
Jin, G1
Wei, F1
Guan, W1
Zhong, N1
An, YJ1
Cho, HR1
Kim, TM1
Keam, B1
Kim, JW1
Wen, H1
Park, CK1
Lee, SH1
Im, SA1
Kim, JE1
Choi, SH1
Park, S1
Makinoshima, H2
Takita, M2
Matsumoto, S2
Yagishita, A1
Owada, S1
Esumi, H2
Tsuchihara, K2
Shi, X1
Li, C1
Gao, S1
Shi, W1
Yizhak, K1
Le Dévédec, SE1
Rogkoti, VM1
Baenke, F1
de Boer, VC1
Frezza, C1
Schulze, A1
van de Water, B1
Ruppin, E1
Nejati-Koshki, K1
Mesgari, M1
Ebrahimi, E1
Abbasalizadeh, F1
Fekri Aval, S1
Khandaghi, AA1
Abasi, M1
Akbarzadeh, A2
Chittasupho, C1
Lirdprapamongkol, K1
Kewsuwan, P1
Sarisuta, N1
Gross, BP1
Wongrakpanich, A1
Francis, MB1
Salem, AK1
Norian, LA1
Feng, T1
Tian, H1
Xu, C1
Lin, L1
Xie, Z1
Lam, MH1
Yang, N2
Jiang, Y2
Sun, B1
Hou, C2
Zheng, J2
Zuo, P2
Büll, C1
Boltje, TJ1
van Dinther, EA1
Peters, T1
de Graaf, AM1
Leusen, JH1
Kreutz, M1
Figdor, CG1
den Brok, MH1
Adema, GJ1
Lamichhane, SP1
Arya, N2
Ojha, N1
Kohler, E1
Shastri, VP1
Kaur, J1
Tikoo, K1
Tao, W1
Chang, D1
Wang, T1
Mei, L1
Zeng, X1
Huang, L1
Sankar, R1
Karthik, S1
Subramanian, N1
Krishnaswami, V1
Sonnemann, J1
Ravikumar, V1
Maiolino, S1
Russo, A1
Pagliara, V1
Conte, C1
Ungaro, F1
Russo, G1
Quaglia, F1
Granja, S1
Marchiq, I1
Le Floch, R1
Moura, CS1
Pouysségur, J1
Jung, J1
Song, SY1
Yoon, SM1
Kwak, J1
Yoon, K1
Choi, W1
Jeong, SY1
Choi, EK1
Cho, B1
Katti, DS1
Saruwatari, K1
Umemura, S1
Obata, Y1
Ishii, G1
Sugiyama, E1
Ochiai, A1
Abe, R1
Goto, K1
Manente, AG1
Pinton, G1
Zonca, S1
Cilli, M1
Rinaldi, M1
Daga, A1
Nilsson, S1
Moro, L1
Liang, Z1
Li, D1
Qiu, N1
Wen, J1
Chen, L1
Vlachostergios, PJ1
Oikonomou, KG1
Gibilaro, E1
Apergis, G1
Ma, X1
Deng, J1
Cao, N1
Zheng, Y1
Geng, S1
Meng, M1
Lin, H1
Du, G1
Tian, X1
Lara, H1
Wagner, KT1
Saripalli, S1
Hyder, SN1
Foote, M1
Sethi, M1
Wang, E1
Caster, JM1
Wang, AZ1
Mi, Y1
Mu, C1
Wolfram, J1
Deng, Z1
Hu, TY1
Blanco, E1
Ferrari, M1
Said-Elbahr, R1
Nasr, M1
Alhnan, MA1
Taha, I1
Sammour, O1
Gao, C1
Shen, Y2
Miao, Y1
Qiu, X1
Yuan, X1
Ji, W1
Bao, Y1
Tan, S1
Lu, S1
Wu, K1
Chu, Q2
Sambade, M1
Deal, A1
Schorzman, A1
Luft, JC1
Bowerman, C1
Chu, K1
Karginova, O1
Swearingen, AV1
Zamboni, W1
DeSimone, J1
Anders, CK1
Das, J2
Samadder, A2
Mondal, J1
Abraham, SK1
Khuda-Bukhsh, AR2
Roointan, A1
Sharifi-Rad, M1
Badrzadeh, F1
Sharifi-Rad, J1
Wu, D1
Zhang, A1
Zhang, G1
Sui, H1
Park, K1
Najlah, M1
Ahmed, Z1
Iqbal, M1
Tawari, P1
McConville, C1
Deng, C1
Meng, F1
Sun, H1
Zhong, Z1
Chen, P1
Zuo, H1
Xiong, H1
Kolar, MJ1
Saghatelian, A1
Siegwart, DJ1
Wan, Y1
Amirsaadat, S1
Pilehvar-Soltanahmadi, Y2
Zarghami, F1
Alipour, S1
Ebrahimnezhad, Z1
Zarghami, N2
Sadeghzadeh, H1
Dariushnejad, H1
Sanjarian, F1
Tang, S1
Alahdal, M1
Cao, S1
Zhang, F1
Sun, M1
Mo, R1
Zong, L1
Jin, L1
Yang, R2
Yang, SG1
Shim, WS2
Cui, F1
Cheng, G2
Kim, IW1
Kim, DD2
Chung, SJ2
Shim, CK2
Taetz, S2
Nafee, N3
Beisner, J1
Piotrowska, K1
Baldes, C1
Mürdter, TE2
Huwer, H1
Schneider, M2
Schaefer, UF3
Klotz, U2
Lehr, CM3
Zou, W1
Liu, C1
Zhang, N1
Ding, D1
Xu, X1
Yin, X1
Hu, Y1
Cui, FD1
Han, X1
Jin, QR1
Meisner, D1
Kwong, E1
Wu, XY1
Johnston, MR1
Tomoda, K1
Ohkoshi, T1
Hirota, K1
Sonavane, GS1
Nakajima, T1
Terada, H1
Komuro, M1
Kitazato, K1
Makino, K1
Fan, TW2
Lane, AN1
Higashi, RM2
Farag, MA1
Gao, H1
Bousamra, M1
Miller, DM1
Tahara, K2
Sakai, T1
Yamamoto, H2
Takeuchi, H1
Hirashima, N1
Kawashima, Y5
Sabel, MS1
Su, G1
Griffith, KA1
Chang, AE1
Chun, YW1
Bonuccelli, G1
Tsirigos, A1
Whitaker-Menezes, D1
Pavlides, S1
Pestell, RG1
Chiavarina, B1
Frank, PG1
Flomenberg, N1
Howell, A1
Martinez-Outschoorn, UE1
Sotgia, F1
Lisanti, MP1
Su, MY1
Hsieh, SY1
Lee, YR1
Chang, MC1
Yuan, TT1
Chang, JM1
Broggini-Tenzer, A1
Vuong, V1
Pruschy, M1
Rocha, CM1
Carrola, J1
Barros, AS1
Gil, AM1
Goodfellow, BJ1
Carreira, IM1
Bernardo, J1
Gomes, A1
Sousa, V1
Carvalho, L1
Duarte, IF1
Dong, M1
Philippi, C1
Loretz, B1
Friedel, G1
Ammon-Treiber, S1
Griese, EU1
Devrim, B1
Bozkir, A1
Canefe, K1
Xu, Yp1
Pan, Dh1
Wang, Lz1
Liu, L1
Shao, G1
Yuneva, MO1
Allen, TD1
Ferraris, DV1
Tsukamoto, T1
Matés, JM1
Alonso, FJ1
Seo, Y1
Bishop, JM1
Kowalski, W1
Nocon, D1
Gamian, A1
Kołodziej, J1
Rakus, D1
Das, S1
Bhadra, K1
Su, WP1
Cheng, FY1
Shieh, DB1
Yeh, CS1
Su, WC1
Zhang, GZ1
Huang, GJ1
Li, WL1
Wu, GM1
Qian, GS1
HONMA, H1
YOSHIBA, A1
YOSHIDA, M1
OTRZONSEK, N1
KOSTRZEWSKA, K1
RAMKISSOON, RA1
CHAMBERLAIN, NO1
BAKER, EL1
JENNINGS, ER1
Verrier, S1
Blaker, JJ1
Maquet, V1
Hench, LL1
Boccaccini, AR1
Takenaga, M1
Tamamura, H1
Hiramatsu, K1
Nakamura, N1
Yamaguchi, Y1
Kitagawa, A1
Kawai, S1
Nakashima, H1
Fujii, N1
Igarashi, R1
Higashi, K2
Yokota, H2
Nagao, Y2
Ueda, Y1
Kodama, Y1
Oguchi, M1
Taki, S1
Tonami, H2
Yamamoto, I1
Koukourakis, MI1
Giatromanolaki, A1
Sivridis, E1
Gatter, KC1
Harris, AL1
Matoba, M1
Hara, K1
Tsujimoto, H1
Huang, CC1
Mimura, H1
Miwa, N1
Lavi, G1
Voronov, E1
Dinarello, CA1
Apte, RN1
Cohen, S1
Wang, P1
Jia, L1
Sanders, BG1
Kline, K1
Christofk, HR1
Vander Heiden, MG1
Harris, MH1
Ramanathan, A1
Gerszten, RE1
Wei, R1
Fleming, MD1
Schreiber, SL1
Cantley, LC1
Simonsen, L1
Bülow, J1
Tuxen, C1
Christensen, NJ1
Sri-Pathmanathan, RM1
Plumb, JA1
Fearon, KC1
Egilmez, NK1
Jong, YS1
Iwanuma, Y1
Jacob, JS1
Santos, CA1
Chen, FA1
Mathiowitz, E1
Bankert, RB1
Kristjansen, PE1
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Ikada, Y1
Hagiwara, A1
Takahashi, T1
Yamaguchi, T1
Taniguchi, H1
Iwamoto, A1
Yoneyama, C1
Ito, M1
Sasabe, T1
Lee, M1
Gorozhanskaia, EG1
Gromova, EG1
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Gästrin, B1
Lövestad, A1
Miyoshi, S2
Nakahara, K2
Monden, Y2
Ohno, K1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Pilot Study To Investigate Targetable Metabolic Pathways Sustaining Triple Negative (TN) Breast Cancer and Associated Genomic Alterations[NCT03457779]16 participants (Actual)Interventional2018-02-08Completed
18F-FDG Metabolism Imaging Monitoring Non-small Cell Lung Cancer Curative Effect of Chemotherapy Multicenter Clinical Study[NCT02938546]Phase 3200 participants (Anticipated)Interventional2016-11-30Not yet recruiting
The Role of Pyruvate Kinase M2 in Growth, Invasion and Drug Resistance in Human Urothelial Carcinoma[NCT01968928]25 participants (Anticipated)Observational [Patient Registry]2014-01-31Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

4 reviews available for lactic acid and Lung Neoplasms

ArticleYear
Prognostic Value of Monocarboxylate Transporter 1 Overexpression in Cancer: A Systematic Review.
    International journal of molecular sciences, 2023, Mar-07, Volume: 24, Issue:6

    Topics: Carcinoma, Non-Small-Cell Lung; Humans; Lactic Acid; Lung Neoplasms; Monocarboxylic Acid Transporter

2023
On macrophage diversity and inflammatory metabolic timers.
    Nature reviews. Immunology, 2020, Volume: 20, Issue:2

    Topics: Animals; Gene Expression; Gene Expression Profiling; Humans; Inflammation; Lactic Acid; Lung Neoplas

2020
Potential therapeutics using tumor-secreted lactate in nonsmall cell lung cancer.
    Drug discovery today, 2021, Volume: 26, Issue:11

    Topics: Anaplastic Lymphoma Kinase; Animals; Carcinoma, Non-Small-Cell Lung; Citric Acid Cycle; Drug Resista

2021
Safety and outcome of treatment of metastatic melanoma using 3-bromopyruvate: a concise literature review and case study.
    Chinese journal of cancer, 2014, Volume: 33, Issue:7

    Topics: Acetaminophen; Adult; Carcinoma, Hepatocellular; Disease Progression; Drug Therapy, Combination; Enz

2014

Trials

3 trials available for lactic acid and Lung Neoplasms

ArticleYear
Local production of lactate, ribose phosphate, and amino acids within human triple-negative breast cancer.
    Med (New York, N.Y.), 2021, 06-11, Volume: 2, Issue:6

    Topics: Amino Acids; Carcinoma, Non-Small-Cell Lung; Glucose; Humans; Lactic Acid; Lung Neoplasms; Proteomic

2021
Elevated lactic acid is a negative prognostic factor in metastatic lung cancer.
    Cancer biomarkers : section A of Disease markers, 2015, Volume: 15, Issue:6

    Topics: Adenocarcinoma; Aged; Aged, 80 and over; Biomarkers, Tumor; Carcinoma, Large Cell; Carcinoma, Non-Sm

2015
Glucose-induced thermogenesis in patients with small cell lung carcinoma. The effect of acute beta-adrenergic inhibition.
    Clinical physiology (Oxford, England), 1994, Volume: 14, Issue:5

    Topics: Aged; Blood Flow Velocity; Blood Glucose; Blood Pressure; Carcinoma, Small Cell; Catecholamines; Ene

1994

Other Studies

156 other studies available for lactic acid and Lung Neoplasms

ArticleYear
l-lactic acidosis confers insensitivity to PKC inhibitors by competing for uptake via monocarboxylate transporters.
    Journal of cellular physiology, 2022, Volume: 237, Issue:1

    Topics: Acidosis, Lactic; Carcinoma, Non-Small-Cell Lung; ErbB Receptors; Humans; Lactic Acid; Lung Neoplasm

2022
Notch1/TAZ axis promotes aerobic glycolysis and immune escape in lung cancer.
    Cell death & disease, 2021, 09-04, Volume: 12, Issue:9

    Topics: Aerobiosis; Animals; Cell Line, Tumor; Feedback, Physiological; Gene Expression Regulation, Neoplast

2021
An integrated metabonomics study to reveal the inhibitory effect and metabolism regulation of taurine on breast cancer.
    Journal of pharmaceutical and biomedical analysis, 2022, May-30, Volume: 214

    Topics: Animals; Arginine; Breast Neoplasms; Choline; Female; Glutamic Acid; Histidine; Humans; Isoleucine;

2022
Efficacy of siRNA-loaded nanoparticles in the treatment of K-RAS mutant lung cancer
    Journal of microencapsulation, 2022, Volume: 39, Issue:3

    Topics: Humans; Lactic Acid; Lung Neoplasms; Nanoparticles; Particle Size; Polylactic Acid-Polyglycolic Acid

2022
Aspirin blocks AMPK/SIRT3-mediated glycolysis to inhibit NSCLC cell proliferation.
    European journal of pharmacology, 2022, Oct-15, Volume: 932

    Topics: AMP-Activated Protein Kinases; Aspirin; Carcinoma, Non-Small-Cell Lung; Cell Proliferation; Glycolys

2022
Identifying a lactic acid metabolism-related gene signature contributes to predicting prognosis, immunotherapy efficacy, and tumor microenvironment of lung adenocarcinoma.
    Frontiers in immunology, 2022, Volume: 13

    Topics: Adenocarcinoma of Lung; Erlotinib Hydrochloride; Etoposide; Gefitinib; Humans; Immunologic Factors;

2022
Cabozantinib-Loaded PLGA Nanoparticles: A Potential Adjuvant Strategy for Surgically Resected High-Risk Non-Metastatic Renal Cell Carcinoma.
    International journal of molecular sciences, 2022, Oct-20, Volume: 23, Issue:20

    Topics: Animals; Carcinoma, Renal Cell; Drug Carriers; Emulsions; Humans; Kidney Neoplasms; Lactic Acid; Lun

2022
Lactate regulators contribute to tumor microenvironment and predict prognosis in lung adenocarcinoma.
    Frontiers in immunology, 2022, Volume: 13

    Topics: Adenocarcinoma of Lung; Humans; Lactic Acid; Lung Neoplasms; Programmed Cell Death 1 Receptor; Tumor

2022
Lactate regulators contribute to tumor microenvironment and predict prognosis in lung adenocarcinoma.
    Frontiers in immunology, 2022, Volume: 13

    Topics: Adenocarcinoma of Lung; Humans; Lactic Acid; Lung Neoplasms; Programmed Cell Death 1 Receptor; Tumor

2022
Lactate regulators contribute to tumor microenvironment and predict prognosis in lung adenocarcinoma.
    Frontiers in immunology, 2022, Volume: 13

    Topics: Adenocarcinoma of Lung; Humans; Lactic Acid; Lung Neoplasms; Programmed Cell Death 1 Receptor; Tumor

2022
Lactate regulators contribute to tumor microenvironment and predict prognosis in lung adenocarcinoma.
    Frontiers in immunology, 2022, Volume: 13

    Topics: Adenocarcinoma of Lung; Humans; Lactic Acid; Lung Neoplasms; Programmed Cell Death 1 Receptor; Tumor

2022
Formosanin C inhibits non-small-cell lung cancer progression by blocking MCT4/CD147-mediated lactate export.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2023, Volume: 109

    Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Diosgenin; Humans; Lactic Acid

2023
Circ_0110498 facilitates the cisplatin resistance of non-small cell lung cancer by mediating the miR-1287-5p/RBBP4 axis.
    Thoracic cancer, 2023, Volume: 14, Issue:7

    Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cisplatin; Drug Resistance, Ne

2023
HDAC6-G3BP2 promotes lysosomal-TSC2 and suppresses mTORC1 under ETV4 targeting-induced low-lactate stress in non-small cell lung cancer.
    Oncogene, 2023, Volume: 42, Issue:15

    Topics: Adaptor Proteins, Signal Transducing; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Histone Deac

2023
Hyperoxia induces glucose metabolism reprogramming and intracellular acidification by suppressing MYC/MCT1 axis in lung cancer.
    Redox biology, 2023, Volume: 61

    Topics: Cell Line, Tumor; Glucose; Humans; Hydrogen-Ion Concentration; Hyperoxia; Lactic Acid; Lung Neoplasm

2023
Molecular Characterization and Prognosis of Lactate-Related Genes in Lung Adenocarcinoma.
    Current oncology (Toronto, Ont.), 2023, 02-27, Volume: 30, Issue:3

    Topics: Adenocarcinoma of Lung; DNA Copy Number Variations; Humans; Lactic Acid; Lung Neoplasms; Prognosis;

2023
Dietary Folate Deficiency Promotes Lactate Metabolic Disorders to Sensitize Lung Cancer Metastasis through MTOR-Signaling-Mediated Druggable Oncotargets.
    Nutrients, 2023, Mar-21, Volume: 15, Issue:6

    Topics: Animals; Diet; Folic Acid; Folic Acid Deficiency; L-Lactate Dehydrogenase; Lactic Acid; Lung Neoplas

2023
Exhaled breath condensate identifies metabolic dysregulation in patients with radiation-induced lung injury.
    American journal of physiology. Lung cellular and molecular physiology, 2023, 06-01, Volume: 324, Issue:6

    Topics: Biomarkers; Breath Tests; Humans; Idiopathic Pulmonary Fibrosis; Lactic Acid; Lung; Lung Injury; Lun

2023
GRIN2D knockdown suppresses the progression of lung adenocarcinoma by regulating the E2F signalling pathway.
    Cellular signalling, 2023, Volume: 107

    Topics: Adenocarcinoma; Adenocarcinoma of Lung; Cell Proliferation; Gene Expression Regulation, Neoplastic;

2023
Candida expansion in the gut of lung cancer patients associates with an ecological signature that supports growth under dysbiotic conditions.
    Nature communications, 2023, 05-09, Volume: 14, Issue:1

    Topics: Candida; Cross-Sectional Studies; Dysbiosis; Female; Humans; Lactic Acid; Lung Neoplasms; Male

2023
A novel molecular mechanism mediated by circCCDC134 regulates non-small cell lung cancer progression.
    Thoracic cancer, 2023, Volume: 14, Issue:20

    Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cell Proliferation; Exosomes; Humans; Lactic Acid; Lung Neo

2023
M2 macrophage exosomal LINC01001 promotes non-small cell lung cancer development by affecting METTL3 and glycolysis pathway.
    Cancer gene therapy, 2023, Volume: 30, Issue:11

    Topics: Animals; Carcinoma, Non-Small-Cell Lung; Glycolysis; Lactic Acid; Lung Neoplasms; Macrophages; Mice

2023
BZW2 Modulates Lung Adenocarcinoma Progression through Glycolysis-Mediated IDH3G Lactylation Modification.
    Journal of proteome research, 2023, 12-01, Volume: 22, Issue:12

    Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Cell Line, Tumor; Cell Proliferation; Gene Expressi

2023
A Case of Lung Involvement in Peripheral T Cell Lymphoma.
    Clinical laboratory, 2019, Oct-01, Volume: 65, Issue:10

    Topics: Acidosis, Lactic; Adult; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Cyclophosphamide; D

2019
A lactate-induced Snail/STAT3 pathway drives GPR81 expression in lung cancer cells.
    Biochimica et biophysica acta. Molecular basis of disease, 2020, 01-01, Volume: 1866, Issue:1

    Topics: A549 Cells; Cell Line, Tumor; Disease Progression; Humans; Lactic Acid; Lung Neoplasms; Receptors, G

2020
Dietary 2-deoxy-D-glucose impairs tumour growth and metastasis by inhibiting angiogenesis.
    European journal of cancer (Oxford, England : 1990), 2019, Volume: 123

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Angiogenesis Inhibitors; Animals; Antimetabolites; Ca

2019
Lactate-fueled oxidative metabolism drives DNA methyltransferase 1-mediated transcriptional co-activator with PDZ binding domain protein activation.
    Cancer science, 2020, Volume: 111, Issue:1

    Topics: Cell Line, Tumor; DNA (Cytosine-5-)-Methyltransferase 1; Glycogen Synthase Kinase 3 beta; Humans; In

2020
Novel Approach to Generate a Self-Deliverable Ru(II)-Based Anticancer Agent in the Self-Reacting Confined Gel Space.
    ACS applied materials & interfaces, 2019, Dec-18, Volume: 11, Issue:50

    Topics: A549 Cells; Antineoplastic Agents; Apoptosis; Cell Proliferation; Coordination Complexes; Dimethyl S

2019
Identification of a new
    Future oncology (London, England), 2019, Volume: 15, Issue:36

    Topics: Alternative Splicing; Animals; Base Sequence; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferat

2019
DRP1 promotes lactate utilization in KRAS-mutant non-small-cell lung cancer cells.
    Cancer science, 2020, Volume: 111, Issue:10

    Topics: A549 Cells; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Death; Cell Line, Tumor; Cell Proliferat

2020
Characterization of an Aggregated Three-Dimensional Cell Culture Model by Multimodal Mass Spectrometry Imaging.
    Analytical chemistry, 2020, 09-15, Volume: 92, Issue:18

    Topics: Adenocarcinoma of Lung; Citric Acid; Glutamine; Humans; Lactic Acid; Lung Neoplasms; Multimodal Imag

2020
Inhalable functional mixed-polymer microspheres to enhance doxorubicin release behavior for lung cancer treatment.
    Colloids and surfaces. B, Biointerfaces, 2020, Volume: 196

    Topics: Animals; Doxorubicin; Lactic Acid; Lung; Lung Neoplasms; Mice; Mice, Inbred BALB C; Microspheres; Pa

2020
Di-methylation of CD147-K234 Promotes the Progression of NSCLC by Enhancing Lactate Export.
    Cell metabolism, 2021, 01-05, Volume: 33, Issue:1

    Topics: Animals; Basigin; Carcinoma, Non-Small-Cell Lung; Cell Line; Humans; Lactic Acid; Lung Neoplasms; Ma

2021
Anti-Warburg effect by targeting HRD1-PFKP pathway may inhibit breast cancer progression.
    Cell communication and signaling : CCS, 2021, 02-15, Volume: 19, Issue:1

    Topics: Adenosine Triphosphate; Animals; Breast Neoplasms; Cell Line; Cell Movement; Cell Proliferation; Dis

2021
Isovitexin potentiated the antitumor activity of cisplatin by inhibiting the glucose metabolism of lung cancer cells and reduced cisplatin-induced immunotoxicity in mice.
    International immunopharmacology, 2021, Volume: 94

    Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Apigenin; Carcinoma, Non-Small-Cell Lung; Ca

2021
Cigarette smoke extract reduces FOXO3a promoting tumor progression and cell migration in lung cancer.
    Toxicology, 2021, 04-30, Volume: 454

    Topics: A549 Cells; Cell Line, Tumor; Cell Movement; Disease Progression; Down-Regulation; Forkhead Box Prot

2021
Isovitexin Suppresses Stemness of Lung Cancer Stem-Like Cells through Blockage of MnSOD/CaMKII/AMPK Signaling and Glycolysis Inhibition.
    BioMed research international, 2021, Volume: 2021

    Topics: A549 Cells; Adenylate Kinase; Animals; Apigenin; Calcium-Calmodulin-Dependent Protein Kinase Type 2;

2021
Artesunate-loaded porous PLGA microsphere as a pulmonary delivery system for the treatment of non-small cell lung cancer.
    Colloids and surfaces. B, Biointerfaces, 2021, Volume: 206

    Topics: Artesunate; Carcinoma, Non-Small-Cell Lung; Humans; Lactic Acid; Lung Neoplasms; Microspheres; Parti

2021
Lactate secreted by PKM2 upregulation promotes Galectin-9-mediated immunosuppression via inhibiting NF-κB pathway in HNSCC.
    Cell death & disease, 2021, 07-21, Volume: 12, Issue:8

    Topics: Base Sequence; Carrier Proteins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Galectins; Gen

2021
Pulmonary Delivery of Docetaxel and Celecoxib by PLGA Porous Microparticles for Their Synergistic Effects Against Lung Cancer.
    Anti-cancer agents in medicinal chemistry, 2022, Volume: 22, Issue:5

    Topics: Celecoxib; Docetaxel; Drug Carriers; Humans; Lactic Acid; Lung Neoplasms; Particle Size; Porosity

2022
Tumor cell-derived lactate induces TAZ-dependent upregulation of PD-L1 through GPR81 in human lung cancer cells.
    Oncogene, 2017, 10-19, Volume: 36, Issue:42

    Topics: Apoptosis; B7-H1 Antigen; Cell Line, Tumor; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Gene E

2017
Lactate Metabolism in Human Lung Tumors.
    Cell, 2017, Oct-05, Volume: 171, Issue:2

    Topics: Animals; Blood Chemical Analysis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Citric Acid Cycl

2017
Polymeric Nano-Encapsulation of Curcumin Enhances its Anti-Cancer Activity in Breast (MDA-MB231) and Lung (A549) Cancer Cells Through Reduction in Expression of HIF-1α and Nuclear p65 (Rel A).
    Current drug delivery, 2018, Feb-14, Volume: 15, Issue:2

    Topics: A549 Cells; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Curcumin; Drug Carriers; Huma

2018
Expression of PFKFB3 and Ki67 in lung adenocarcinomas and targeting PFKFB3 as a therapeutic strategy.
    Molecular and cellular biochemistry, 2018, Volume: 445, Issue:1-2

    Topics: A549 Cells; Adenocarcinoma; Adenocarcinoma of Lung; Adult; Aged; Aged, 80 and over; Apoptosis; Bioma

2018
Downregulation of Membrane Trafficking Proteins and Lactate Conditioning Determine Loss of Dendritic Cell Function in Lung Cancer.
    Cancer research, 2018, 04-01, Volume: 78, Issue:7

    Topics: Animals; Antigen Presentation; Antigens, Neoplasm; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Cul

2018
Upregulation of lactate-inducible snail protein suppresses oncogene-mediated senescence through p16
    Journal of experimental & clinical cancer research : CR, 2018, Feb-26, Volume: 37, Issue:1

    Topics: Alveolar Epithelial Cells; Animals; Cell Line, Tumor; Cellular Senescence; Cyclin-Dependent Kinase I

2018
Targeted delivery of monoclonal antibody conjugated docetaxel loaded PLGA nanoparticles into EGFR overexpressed lung tumour cells.
    Journal of microencapsulation, 2018, Volume: 35, Issue:2

    Topics: A549 Cells; Animals; Antineoplastic Agents; Apoptosis; Cetuximab; Docetaxel; Drug Carriers; Drug Del

2018
Polymer nanofiber-based microchips for EGFR mutation analysis of circulating tumor cells in lung adenocarcinoma.
    International journal of nanomedicine, 2018, Volume: 13

    Topics: Adenocarcinoma; Adenocarcinoma of Lung; Base Sequence; Carcinoma, Non-Small-Cell Lung; Cell Count; C

2018
The effect of the androstane lung cancer inhibitor content on the cell-selective toxicity of hydroxyapatite-chitosan-PLGA nanocomposites.
    Materials science & engineering. C, Materials for biological applications, 2018, Aug-01, Volume: 89

    Topics: A549 Cells; Androstanes; Calorimetry, Differential Scanning; Cell Line; Cell Survival; Chitosan; Dru

2018
MiR-182 promotes glucose metabolism by upregulating hypoxia-inducible factor 1α in NSCLC cells.
    Biochemical and biophysical research communications, 2018, 10-02, Volume: 504, Issue:2

    Topics: 3' Untranslated Regions; Carcinoma, Non-Small-Cell Lung; Cell Hypoxia; Cell Line, Tumor; Cell Prolif

2018
MicroRNA-31-5p enhances the Warburg effect via targeting FIH.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019, Volume: 33, Issue:1

    Topics: Animals; Apoptosis; Cell Proliferation; Gene Expression Regulation, Neoplastic; Glycolysis; Humans;

2019
Promoted delivery of salinomycin sodium to lung cancer cells by dual targeting PLGA hybrid nanoparticles.
    International journal of oncology, 2018, Volume: 53, Issue:3

    Topics: AC133 Antigen; Animals; Antibiotics, Antineoplastic; Cell Line, Tumor; Drug Delivery Systems; ErbB R

2018
Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies.
    Cell metabolism, 2018, 12-04, Volume: 28, Issue:6

    Topics: Animals; Antineoplastic Agents; Cancer-Associated Fibroblasts; Cell Line, Tumor; Cell Transformation

2018
Targeting Tumor Microenvironment by Bioreduction-Activated Nanoparticles for Light-Triggered Virotherapy.
    ACS nano, 2018, 10-23, Volume: 12, Issue:10

    Topics: Animals; Antineoplastic Agents; Cell Proliferation; Cells, Cultured; Dependovirus; HEK293 Cells; Hum

2018
Lactate inhibits ATP6V0d2 expression in tumor-associated macrophages to promote HIF-2α-mediated tumor progression.
    The Journal of clinical investigation, 2019, 02-01, Volume: 129, Issue:2

    Topics: Adenocarcinoma of Lung; Animals; Basic Helix-Loop-Helix Transcription Factors; Female; Gene Expressi

2019
Transmembrane Protease TMPRSS11B Promotes Lung Cancer Growth by Enhancing Lactate Export and Glycolytic Metabolism.
    Cell reports, 2018, 11-20, Volume: 25, Issue:8

    Topics: Basigin; Biological Transport; Carcinogenesis; Cell Line, Tumor; Cell Membrane; Cell Proliferation;

2018
Controlled preparation and antitumor efficacy of vitamin E TPGS-functionalized PLGA nanoparticles for delivery of paclitaxel.
    International journal of pharmaceutics, 2013, Mar-25, Volume: 446, Issue:1-2

    Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Chemical Precipitation; Delayed-Action

2013
Supercritical fluid technology based large porous celecoxib-PLGA microparticles do not induce pulmonary fibrosis and sustain drug delivery and efficacy for several weeks following a single dose.
    Journal of controlled release : official journal of the Controlled Release Society, 2013, Jun-28, Volume: 168, Issue:3

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzo(a)pyrene; Bron

2013
Microencapsulation of alpha-mangostin into PLGA microspheres and optimization using response surface methodology intended for pulmonary delivery.
    Journal of microencapsulation, 2013, Volume: 30, Issue:8

    Topics: Administration, Inhalation; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Drug Carriers; Drug Co

2013
Effects of chemically modified nanostructured PLGA on functioning of lung and breast cancer cells.
    International journal of nanomedicine, 2013, Volume: 8

    Topics: Alginates; Analysis of Variance; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Pro

2013
Doxorubicin-loaded porous PLGA microparticles with surface attached TRAIL for the inhalation treatment of metastatic lung cancer.
    Biomaterials, 2013, Volume: 34, Issue:27

    Topics: Administration, Inhalation; Animals; Antibiotics, Antineoplastic; Cell Line, Tumor; Delayed-Action P

2013
Relationships between LDH-A, lactate, and metastases in 4T1 breast tumors.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2013, Sep-15, Volume: 19, Issue:18

    Topics: Adenosine Triphosphate; Animals; Breast Neoplasms; Cell Adhesion; Cell Movement; Cell Proliferation;

2013
Antibody conjugated PLGA nanoparticles for targeted delivery of paclitaxel palmitate: efficacy and biofate in a lung cancer mouse model.
    Small (Weinheim an der Bergstrasse, Germany), 2013, Dec-20, Volume: 9, Issue:24

    Topics: Amides; Animals; Antibodies; Antibodies, Monoclonal, Humanized; Area Under Curve; Cell Line, Tumor;

2013
[Study on the anti-Lewis lung carcinoma effect of metformin combined with MCT1 inhibitor CHC].
    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2013, Volume: 44, Issue:3

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Lewis Lung; Coumaric

2013
Therapeutic role of EF24 targeting glucose transporter 1-mediated metabolism and metastasis in ovarian cancer cells.
    Cancer science, 2013, Volume: 104, Issue:12

    Topics: Animals; Benzylidene Compounds; Biological Transport; Cell Line, Tumor; Cell Movement; Cell Prolifer

2013
Activity of the monocarboxylate transporter 1 inhibitor AZD3965 in small cell lung cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2014, Feb-15, Volume: 20, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Animals; Antineoplastic Agents; Cell Death; Cell Line, Tumor; Drug R

2014
Magnetic resonance imaging of tumor glycolysis using hyperpolarized 13C-labeled glucose.
    Nature medicine, 2014, Volume: 20, Issue:1

    Topics: Animals; Carbon Isotopes; Glucose; Glycolysis; Lactic Acid; Lung Neoplasms; Lymphoma; Magnetic Reson

2014
Targeting cisplatin-resistant human tumor cells with metabolic inhibitors.
    Cancer chemotherapy and pharmacology, 2014, Volume: 73, Issue:2

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cisplatin; Deoxyglucose; Drug Resistance, Neoplasm; Female;

2014
HIF-1-mediated metabolic reprogramming reduces ROS levels and facilitates the metastatic colonization of cancers in lungs.
    Scientific reports, 2014, Jan-23, Volume: 4

    Topics: Anaerobiosis; Animals; Female; Glucose; Glycolysis; Hypoxia-Inducible Factor 1; Immunoenzyme Techniq

2014
Preparation of lung-targeting, emodin-loaded polylactic acid microspheres and their properties.
    International journal of molecular sciences, 2014, Apr-11, Volume: 15, Issue:4

    Topics: Animals; Drug Carriers; Emodin; Gelatin; Injections, Intravenous; Lactic Acid; Lung Diseases; Lung N

2014
An NMR metabolomics approach for the diagnosis of leptomeningeal carcinomatosis in lung adenocarcinoma cancer patients.
    International journal of cancer, 2015, Jan-01, Volume: 136, Issue:1

    Topics: Adenocarcinoma; Alanine; Area Under Curve; Biomarkers, Tumor; Case-Control Studies; Citric Acid; Cre

2015
Epidermal growth factor receptor (EGFR) signaling regulates global metabolic pathways in EGFR-mutated lung adenocarcinoma.
    The Journal of biological chemistry, 2014, Jul-25, Volume: 289, Issue:30

    Topics: Adenocarcinoma; Aspartate Carbamoyltransferase; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing)

2014
Combination of doxorubicin-based chemotherapy and polyethylenimine/p53 gene therapy for the treatment of lung cancer using porous PLGA microparticles.
    Colloids and surfaces. B, Biointerfaces, 2014, Oct-01, Volume: 122

    Topics: Antibiotics, Antineoplastic; Cell Line, Tumor; Doxorubicin; Flow Cytometry; Genes, p53; Genetic Ther

2014
A computational study of the Warburg effect identifies metabolic targets inhibiting cancer migration.
    Molecular systems biology, 2014, Aug-01, Volume: 10

    Topics: Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Computational Biology; Gene S

2014
Synthesis and in vitro study of cisplatin-loaded Fe3O4 nanoparticles modified with PLGA-PEG6000 copolymers in treatment of lung cancer.
    Journal of microencapsulation, 2014, Volume: 31, Issue:8

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cisplatin; Drug Screening Assays, Antitumor; Ferric Compoun

2014
Targeted delivery of doxorubicin to A549 lung cancer cells by CXCR4 antagonist conjugated PLGA nanoparticles.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2014, Volume: 88, Issue:2

    Topics: Antibiotics, Antineoplastic; Cell Line, Tumor; Doxorubicin; Humans; Lactic Acid; Lung Neoplasms; Mic

2014
A therapeutic microparticle-based tumor lysate vaccine reduces spontaneous metastases in murine breast cancer.
    The AAPS journal, 2014, Volume: 16, Issue:6

    Topics: Animals; Antigens, Neoplasm; Autoimmunity; Biocompatible Materials; Cancer Vaccines; CD8-Positive T-

2014
Synergistic co-delivery of doxorubicin and paclitaxel by porous PLGA microspheres for pulmonary inhalation treatment.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2014, Volume: 88, Issue:3

    Topics: Administration, Inhalation; Animals; Antineoplastic Agents; Doxorubicin; Drug Carriers; Drug Deliver

2014
Active targeting docetaxel-PLA nanoparticles eradicate circulating lung cancer stem-like cells and inhibit liver metastasis.
    Molecular pharmaceutics, 2015, Jan-05, Volume: 12, Issue:1

    Topics: AC133 Antigen; Animals; Antigens, CD; Antineoplastic Agents; Body Weight; Cell Line, Tumor; Docetaxe

2015
Targeted delivery of a sialic acid-blocking glycomimetic to cancer cells inhibits metastatic spread.
    ACS nano, 2015, Jan-27, Volume: 9, Issue:1

    Topics: Animals; Antibodies; Biomimetic Materials; Drug Carriers; Female; Lactic Acid; Lung Neoplasms; Melan

2015
Glycosaminoglycan-functionalized poly-lactide-co-glycolide nanoparticles: synthesis, characterization, cytocompatibility, and cellular uptake.
    International journal of nanomedicine, 2015, Volume: 10

    Topics: Cell Proliferation; Cells, Cultured; Endothelium, Vascular; Glycosaminoglycans; Humans; Kidney Tubul

2015
Ets1 identified as a novel molecular target of RNA aptamer selected against metastatic cells for targeted delivery of nano-formulation.
    Oncogene, 2015, Oct-08, Volume: 34, Issue:41

    Topics: Animals; Antineoplastic Agents; Aptamers, Nucleotide; Cell Line, Tumor; Cell Membrane Permeability;

2015
Doxorubicin-loaded star-shaped copolymer PLGA-vitamin E TPGS nanoparticles for lung cancer therapy.
    Journal of materials science. Materials in medicine, 2015, Volume: 26, Issue:4

    Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; Cell Line, Tumor; Cell Survival; Delayed-Action Pre

2015
Nanostructured delivery system for Suberoylanilide hydroxamic acid against lung cancer cells.
    Materials science & engineering. C, Materials for biological applications, 2015, Volume: 51

    Topics: Apoptosis; Cell Line, Tumor; Cell Survival; Diffusion; Drug Synergism; Humans; Hydroxamic Acids; Lac

2015
Biodegradable nanoparticles sequentially decorated with Polyethyleneimine and Hyaluronan for the targeted delivery of docetaxel to airway cancer cells.
    Journal of nanobiotechnology, 2015, Apr-03, Volume: 13

    Topics: Antineoplastic Agents; Biocompatible Materials; Cell Line; Docetaxel; Drug Delivery Systems; Drug St

2015
Disruption of BASIGIN decreases lactic acid export and sensitizes non-small cell lung cancer to biguanides independently of the LKB1 status.
    Oncotarget, 2015, Mar-30, Volume: 6, Issue:9

    Topics: AMP-Activated Protein Kinase Kinases; Animals; Antineoplastic Agents; Basigin; Biological Transport;

2015
Verification of Accuracy of CyberKnife Tumor-tracking Radiation Therapy Using Patient-specific Lung Phantoms.
    International journal of radiation oncology, biology, physics, 2015, Jul-15, Volume: 92, Issue:4

    Topics: Carcinoma, Non-Small-Cell Lung; Fiducial Markers; Humans; Lactic Acid; Lung; Lung Neoplasms; Medical

2015
Poly(d,l-lactide-co-glycolide)-chitosan composite particles for the treatment of lung cancer.
    International journal of nanomedicine, 2015, Volume: 10

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Chitosan; Drug Carriers; Drug Synergism; Hum

2015
Signaling through the Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Axis Is Responsible for Aerobic Glycolysis mediated by Glucose Transporter in Epidermal Growth Factor Receptor (EGFR)-mutated Lung Adenocarcinoma.
    The Journal of biological chemistry, 2015, Jul-10, Volume: 290, Issue:28

    Topics: Adenocarcinoma; Adenocarcinoma of Lung; Aerobiosis; Cell Line, Tumor; Cell Proliferation; ErbB Recep

2015
Intracellular lactate-mediated induction of estrogen receptor beta (ERβ) in biphasic malignant pleural mesothelioma cells.
    Oncotarget, 2015, Sep-22, Volume: 6, Issue:28

    Topics: Animals; Antineoplastic Agents, Hormonal; Basigin; Cell Line, Tumor; Cell Proliferation; Estrogen Re

2015
Targeting docetaxel-PLA nanoparticles simultaneously inhibit tumor growth and liver metastases of small cell lung cancer.
    International journal of pharmaceutics, 2015, Oct-15, Volume: 494, Issue:1

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Docetaxel; Drug Carriers; Drug

2015
Preparation, Characterization, and In Vivo Study of 7-Ethyl-14-Aminocamptothecin-Loaded Poly(Ethylene Glycol)2000 -Poly(Lactic Acid)2000 Polymeric Micelles Against H460 Human Nonsmall Cell Lung Carcinoma.
    Journal of pharmaceutical sciences, 2015, Volume: 104, Issue:11

    Topics: Animals; Antineoplastic Agents; Camptothecin; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell

2015
Lasting glycolytic stress governs susceptibility to urethane-induced lung carcinogenesis in vivo and in vitro.
    Toxicology letters, 2016, Jan-05, Volume: 240, Issue:1

    Topics: Animals; Carcinogenesis; Carcinogens; Cell Line, Tumor; Deoxyglucose; Disease Models, Animal; Diseas

2016
Improving DNA double-strand repair inhibitor KU55933 therapeutic index in cancer radiotherapy using nanoparticle drug delivery.
    Nanoscale, 2015, Dec-21, Volume: 7, Issue:47

    Topics: Animals; Carcinoma, Non-Small-Cell Lung; DNA Breaks, Double-Stranded; Drug Carriers; Drug Delivery S

2015
A Micro/Nano Composite for Combination Treatment of Melanoma Lung Metastasis.
    Advanced healthcare materials, 2016, Apr-20, Volume: 5, Issue:8

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Combined Modality Therapy; Docetaxel; Drug Synergi

2016
Nebulizable colloidal nanoparticles co-encapsulating a COX-2 inhibitor and a herbal compound for treatment of lung cancer.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2016, Volume: 103

    Topics: Animals; Cell Line, Tumor; Colloids; Cyclooxygenase 2 Inhibitors; Herbal Medicine; Humans; Lactic Ac

2016
Cancer Stem Cells in Small Cell Lung Cancer Cell Line H446: Higher Dependency on Oxidative Phosphorylation and Mitochondrial Substrate-Level Phosphorylation than Non-Stem Cancer Cells.
    PloS one, 2016, Volume: 11, Issue:5

    Topics: Adenosine Triphosphate; Animals; Cell Line, Tumor; Cell Proliferation; Energy Metabolism; Extracellu

2016
A novel paclitaxel-loaded poly(d,l-lactide-co-glycolide)-Tween 80 copolymer nanoparticle overcoming multidrug resistance for lung cancer treatment.
    International journal of nanomedicine, 2016, Volume: 11

    Topics: A549 Cells; Animals; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Survival;

2016
Efficacy and pharmacokinetics of a modified acid-labile docetaxel-PRINT(®) nanoparticle formulation against non-small-cell lung cancer brain metastases.
    Nanomedicine (London, England), 2016, Volume: 11, Issue:15

    Topics: Animals; Blood-Brain Barrier; Brain; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Cell Line, Tum

2016
Nano-encapsulated chlorophyllin significantly delays progression of lung cancer both in in vitro and in vivo models through activation of mitochondrial signaling cascades and drug-DNA interaction.
    Environmental toxicology and pharmacology, 2016, Volume: 46

    Topics: Animals; Antineoplastic Agents; Antioxidants; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Chlo

2016
A comparison between PLGA-PEG and NIPAAm-MAA nanocarriers in curcumin delivery for hTERT silencing in lung cancer cell line.
    Cellular and molecular biology (Noisy-le-Grand, France), 2016, Aug-29, Volume: 62, Issue:9

    Topics: Acrylamides; Cell Line, Tumor; Curcumin; Drug Carriers; Gene Expression; Humans; Lactic Acid; Lung N

2016
Improving the Intracellular Drug Concentration in Lung Cancer Treatment through the Codelivery of Doxorubicin and miR-519c Mediated by Porous PLGA Microparticle.
    Molecular pharmaceutics, 2016, 11-07, Volume: 13, Issue:11

    Topics: A549 Cells; Apoptosis; Blotting, Western; Caspase 3; Caspase 8; Caspase 9; Cell Cycle; Cell Survival

2016
Sophoridine-loaded PLGA microspheres for lung targeting: preparation, in vitro, and in vivo evaluation.
    Drug delivery, 2016, Volume: 23, Issue:9

    Topics: Alkaloids; Animals; Chemistry, Pharmaceutical; Delayed-Action Preparations; Drug Carriers; Emulsions

2016
Development and characterisation of disulfiram-loaded PLGA nanoparticles for the treatment of non-small cell lung cancer.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2017, Volume: 112

    Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Disulfiram; Humans; Lactic Acid; Lung Neoplasms; M

2017
Hyaluronic acid coated PLGA nanoparticulate docetaxel effectively targets and suppresses orthotopic human lung cancer.
    Journal of controlled release : official journal of the Controlled Release Society, 2017, 08-10, Volume: 259

    Topics: A549 Cells; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Docetaxel; Drug Carrier

2017
Gpr132 sensing of lactate mediates tumor-macrophage interplay to promote breast cancer metastasis.
    Proceedings of the National Academy of Sciences of the United States of America, 2017, 01-17, Volume: 114, Issue:3

    Topics: Animals; Breast Neoplasms; Cell Adhesion; Cell Cycle Proteins; Cell Line, Tumor; Cell Movement; Fema

2017
Silibinin-loaded magnetic nanoparticles inhibit hTERT gene expression and proliferation of lung cancer cells.
    Artificial cells, nanomedicine, and biotechnology, 2017, Volume: 45, Issue:8

    Topics: A549 Cells; Cell Proliferation; Drug Carriers; Drug Liberation; Gene Expression Regulation, Neoplast

2017
Disulfiram-loaded porous PLGA microparticle for inhibiting the proliferation and migration of non-small-cell lung cancer.
    International journal of nanomedicine, 2017, Volume: 12

    Topics: Administration, Inhalation; Alcohol Deterrents; Blotting, Western; Carcinoma, Non-Small-Cell Lung; C

2017
The Effects of Nanoencapsulated Curcumin-Fe3O4 on Proliferation and hTERT Gene Expression in Lung Cancer Cells.
    Anti-cancer agents in medicinal chemistry, 2017, Volume: 17, Issue:10

    Topics: Antineoplastic Agents; Cell Proliferation; Cell Survival; Curcumin; Dose-Response Relationship, Drug

2017
Targeted delivery of doxorubicin by nano-loaded mesenchymal stem cells for lung melanoma metastases therapy.
    Scientific reports, 2017, 03-17, Volume: 7

    Topics: Animals; Antineoplastic Agents; Cell Death; Cell Survival; Doxorubicin; Drug Delivery Systems; Lacti

2017
Lung-specific delivery of paclitaxel by chitosan-modified PLGA nanoparticles via transient formation of microaggregates.
    Journal of pharmaceutical sciences, 2009, Volume: 98, Issue:3

    Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Survival; Chitosan; Coumarins; La

2009
The influence of chitosan content in cationic chitosan/PLGA nanoparticles on the delivery efficiency of antisense 2'-O-methyl-RNA directed against telomerase in lung cancer cells.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2009, Volume: 72, Issue:2

    Topics: Base Sequence; Cations; Cell Line, Tumor; Chitosan; Chromatography, Gel; Chromatography, High Pressu

2009
Studies on bioadhesive PLGA nanoparticles: A promising gene delivery system for efficient gene therapy to lung cancer.
    International journal of pharmaceutics, 2009, Mar-31, Volume: 370, Issue:1-2

    Topics: Acrylic Resins; Adhesiveness; Cell Line, Tumor; Cell Survival; DNA; Drug Carriers; Gene Transfer Tec

2009
Sustained delivery of endostatin improves the efficacy of therapy in Lewis lung cancer model.
    Journal of controlled release : official journal of the Controlled Release Society, 2009, Mar-04, Volume: 134, Issue:2

    Topics: Angiogenesis Inhibitors; Animals; Delayed-Action Preparations; Disease Models, Animal; Endostatins;

2009
Enhanced electrostatic interaction between chitosan-modified PLGA nanoparticle and tumor.
    International journal of pharmaceutics, 2009, Apr-17, Volume: 371, Issue:1-2

    Topics: Animals; Cell Line, Tumor; Cell Survival; Chitosan; Coumarins; Drug Carriers; Humans; Hydrogen-Ion C

2009
Translymphatic chemotherapy by intrapleural placement of gelatin sponge containing biodegradable Paclitaxel colloids controls lymphatic metastasis in lung cancer.
    Cancer research, 2009, Feb-01, Volume: 69, Issue:3

    Topics: Absorption; Animals; Antineoplastic Agents, Phytogenic; Colloids; Delayed-Action Preparations; Femal

2009
Preparation and properties of inhalable nanocomposite particles for treatment of lung cancer.
    Colloids and surfaces. B, Biointerfaces, 2009, Jul-01, Volume: 71, Issue:2

    Topics: Administration, Inhalation; Aminoquinolines; Animals; Cell Death; Cell Line, Tumor; Epithelial Cells

2009
Altered regulation of metabolic pathways in human lung cancer discerned by (13)C stable isotope-resolved metabolomics (SIRM).
    Molecular cancer, 2009, Jun-26, Volume: 8

    Topics: Aged; Carbon Isotopes; Female; Gas Chromatography-Mass Spectrometry; Gene Expression Profiling; Gluc

2009
Improved cellular uptake of chitosan-modified PLGA nanospheres by A549 cells.
    International journal of pharmaceutics, 2009, Dec-01, Volume: 382, Issue:1-2

    Topics: Adenocarcinoma; Biological Transport, Active; Cell Line, Tumor; Cell Survival; Chemistry, Pharmaceut

2009
Intratumoral delivery of encapsulated IL-12, IL-18 and TNF-alpha in a model of metastatic breast cancer.
    Breast cancer research and treatment, 2010, Volume: 122, Issue:2

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; CD4-Positive T-Lymphocytes; CD8-

2010
Cellular uptake mechanisms and intracellular distributions of polysorbate 80-modified poly (D,L-lactide-co-glycolide) nanospheres for gene delivery.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2010, Volume: 75, Issue:2

    Topics: Adenocarcinoma; Cell Line, Tumor; Clathrin; DNA; Endocytosis; Gene Transfer Techniques; Genetic Vect

2010
Decreased lung carcinoma cell density on select polymer nanometer surface features for lung replacement therapies.
    International journal of nanomedicine, 2010, May-13, Volume: 5

    Topics: Biocompatible Materials; Cell Adhesion; Cell Count; Cell Line, Tumor; Cell Survival; Crystallization

2010
Ketones and lactate "fuel" tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism.
    Cell cycle (Georgetown, Tex.), 2010, Sep-01, Volume: 9, Issue:17

    Topics: 3-Hydroxybutyric Acid; Animals; Autophagy; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Female

2010
The relationship between energy status and AMP-activated protein kinase in human H460 lung cancer cells.
    Cell biochemistry and function, 2010, Volume: 28, Issue:7

    Topics: Adenosine Triphosphate; AMP-Activated Protein Kinases; Cell Line, Tumor; Culture Media, Serum-Free;

2010
Metabolism of tumors under treatment: mapping of metabolites with quantitative bioluminescence.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2011, Volume: 99, Issue:3

    Topics: Adenosine Triphosphate; Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Epothilones; Glyc

2011
Metabolic signatures of lung cancer in biofluids: NMR-based metabonomics of blood plasma.
    Journal of proteome research, 2011, Sep-02, Volume: 10, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Blood Glucose; Female; Humans; Lactic Acid; Lipoproteins; Lung Neopl

2011
Tissue slice model of human lung cancer to investigate telomerase inhibition by nanoparticle delivery of antisense 2'-O-methyl-RNA.
    International journal of pharmaceutics, 2011, Oct-31, Volume: 419, Issue:1-2

    Topics: Carcinoma, Non-Small-Cell Lung; Chitosan; Humans; Lactic Acid; Lung Neoplasms; Nanoparticles; Polygl

2011
Preparation and evaluation of PLGA microparticles as carrier for the pulmonary delivery of rhIL-2 : I. Effects of some formulation parameters on microparticle characteristics.
    Journal of microencapsulation, 2011, Volume: 28, Issue:6

    Topics: Antineoplastic Agents; Cell Survival; Drug Carriers; Drug Compounding; Drug Delivery Systems; Humans

2011
Decreased lung carcinoma cell functions on select polymer nanometer surface features.
    Journal of biomedical materials research. Part A, 2012, Volume: 100, Issue:1

    Topics: Apoptosis; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Cell Shape; Cell Survival; Epithelia

2012
Bioevaluation study of 32P-CP-PLLA particle brachytherapy in a rabbit VX2 lung tumor model.
    Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 2012, Volume: 70, Issue:4

    Topics: Animals; Brachytherapy; Disease Models, Animal; Fluorodeoxyglucose F18; Lactic Acid; Lung Neoplasms;

2012
The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type.
    Cell metabolism, 2012, Feb-08, Volume: 15, Issue:2

    Topics: Animals; Blotting, Western; Cell Line, Tumor; Cell Transformation, Neoplastic; Citric Acid Cycle; DN

2012
Association of C-terminal region of phosphoglycerate mutase with glycolytic complex regulates energy production in cancer cells.
    Journal of cellular physiology, 2012, Volume: 227, Issue:6

    Topics: Active Transport, Cell Nucleus; Adenosine Triphosphate; Animals; Antineoplastic Agents; Carcinoma, N

2012
Doxorubicin-loaded highly porous large PLGA microparticles as a sustained- release inhalation system for the treatment of metastatic lung cancer.
    Biomaterials, 2012, Volume: 33, Issue:22

    Topics: Administration, Inhalation; Animals; Antibiotics, Antineoplastic; Capsules; Delayed-Action Preparati

2012
Poly (lactide-co-glycolide) encapsulated extract of Phytolacca decandra demonstrates better intervention against induced lung adenocarcinoma in mice and on A549 cells.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2012, Sep-29, Volume: 47, Issue:2

    Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Antineoplastic Agents; Arsenites; bcl-2-Associated

2012
PLGA nanoparticles codeliver paclitaxel and Stat3 siRNA to overcome cellular resistance in lung cancer cells.
    International journal of nanomedicine, 2012, Volume: 7

    Topics: Cell Line, Tumor; Drug Resistance, Neoplasm; Humans; Lactic Acid; Lung Neoplasms; Nanoparticles; Pac

2012
[Effect of co-inhibition of MCT1 gene and NHE1 gene on proliferation and growth of human lung adenocarcinoma cells].
    Ai zheng = Aizheng = Chinese journal of cancer, 2002, Volume: 21, Issue:7

    Topics: Adenocarcinoma; Animals; Cell Cycle; Cell Division; Disease Models, Animal; DNA, Antisense; Humans;

2002
[Enzymological observations on lung cancer. An evaluation of changes in lactic acid dehydrogenase activity in patients with primary lung cancer].
    Kyobu geka. The Japanese journal of thoracic surgery, 1962, Volume: 15

    Topics: Clinical Enzyme Tests; Humans; L-Lactate Dehydrogenase; Lactic Acid; Lung Neoplasms

1962
[ACTIVITY OF LACTIC ACID DEHYDROGENASE (SLDH) AND OF AMINOTRANSFERASES (SGOT AND SGPT) IN THE BLOOD SERUM IN PRIMARY PULMONARY CANCER AND TUBERCULOSIS].
    Gruzlica (Warsaw, Poland : 1926), 1963, Volume: 31

    Topics: Alanine Transaminase; Aspartate Aminotransferases; Blood Chemical Analysis; Clinical Enzyme Tests; D

1963
DIAGNOSTIC SIGNIFICANCE OF URINARY LACTIC ACID DEHYDROGENASE.
    The Journal of urology, 1964, Volume: 91

    Topics: Adenocarcinoma; Albuminuria; Carcinoma, Papillary; Carcinoma, Transitional Cell; Clinical Enzyme Tes

1964
PDLLA/Bioglass composites for soft-tissue and hard-tissue engineering: an in vitro cell biology assessment.
    Biomaterials, 2004, Volume: 25, Issue:15

    Topics: Biocompatible Materials; Cell Adhesion; Cell Division; Cell Line, Tumor; Cell Survival; Ceramics; Gl

2004
A single treatment with microcapsules containing a CXCR4 antagonist suppresses pulmonary metastasis of murine melanoma.
    Biochemical and biophysical research communications, 2004, Jul-16, Volume: 320, Issue:1

    Topics: Animals; Antineoplastic Agents; Cell Division; Cell Line, Tumor; Delayed-Action Preparations; Dose-R

2004
In vitro proton magnetic resonance spectroscopic lactate and choline measurements, 18F-FDG uptake, and prognosis in patients with lung adenocarcinoma.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2004, Volume: 45, Issue:8

    Topics: Adenocarcinoma; Aged; Choline; Disease-Free Survival; Female; Fluorodeoxyglucose F18; Humans; Japan;

2004
Pyruvate dehydrogenase and pyruvate dehydrogenase kinase expression in non small cell lung cancer and tumor-associated stroma.
    Neoplasia (New York, N.Y.), 2005, Volume: 7, Issue:1

    Topics: Autopsy; Carcinoma, Non-Small-Cell Lung; Cell Hypoxia; Fibroblasts; Humans; Hypoxia-Inducible Factor

2005
In-vitro 1H-MRS of excised rabbit lung: evaluation of preservation method of the lung using 10% DMSO solution.
    Radiation medicine, 2005, Volume: 23, Issue:8

    Topics: Animals; Choline; Creatine; Dimethyl Sulfoxide; Lactic Acid; Lung; Lung Neoplasms; Magnetic Resonanc

2005
The effect of poly (aspartic acid-co-lactic acid) nanospheres on the lung metastasis of B16BL6 melanoma cells by intravenous administration.
    Oncology reports, 2006, Volume: 16, Issue:6

    Topics: Animals; Biocompatible Materials; Cell Line, Tumor; Delayed-Action Preparations; Injections, Intrave

2006
Chitosan-coated PLGA nanoparticles for DNA/RNA delivery: effect of the formulation parameters on complexation and transfection of antisense oligonucleotides.
    Nanomedicine : nanotechnology, biology, and medicine, 2007, Volume: 3, Issue:3

    Topics: Cell Line, Tumor; Chitosan; Coated Materials, Biocompatible; Crystallization; DNA; Drug Carriers; Dr

2007
Sustained delivery of IL-1 Ra from biodegradable microspheres reduces the number of murine B16 melanoma lung metastases.
    Journal of controlled release : official journal of the Controlled Release Society, 2007, Nov-06, Volume: 123, Issue:2

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Chemistry, Pharmaceutical; Del

2007
Liposomal or nanoparticle alpha-TEA reduced 66cl-4 murine mammary cancer burden and metastasis.
    Drug delivery, 2007, Volume: 14, Issue:8

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Apoptosis; Body Weight; Cell Line, Tumor; Fema

2007
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth.
    Nature, 2008, Mar-13, Volume: 452, Issue:7184

    Topics: Alternative Splicing; Animals; Cell Line, Tumor; Cell Proliferation; Fructosediphosphates; Gene Expr

2008
Clofazimine alters the energy metabolism and inhibits the growth rate of a human lung-cancer cell line in vitro and in vivo.
    International journal of cancer, 1994, Mar-15, Volume: 56, Issue:6

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Carcinoma, Non-Small-Cell Lung; Cell Divisio

1994
Cytokine immunotherapy of cancer with controlled release biodegradable microspheres in a human tumor xenograft/SCID mouse model.
    Cancer immunology, immunotherapy : CII, 1998, Volume: 46, Issue:1

    Topics: Animals; Carcinoma, Squamous Cell; Delayed-Action Preparations; Drug Delivery Systems; Humans; Inter

1998
Intratumor pharmacokinetics, flow resistance, and metabolism during gemcitabine infusion in ex vivo perfused human small cell lung cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1996, Volume: 2, Issue:2

    Topics: Animals; Antimetabolites, Antineoplastic; Carcinoma, Small Cell; Deoxycytidine; Female; Gemcitabine;

1996
T4+ cell numbers are correlated with plasma glutamate and cystine levels: association of hyperglutamataemia with immunodeficiency in diseases with different aetiologies.
    International immunology, 1992, Volume: 4, Issue:1

    Topics: CD4-Positive T-Lymphocytes; Cystine; Glutamates; Glutamic Acid; HIV Seropositivity; HIV-1; Humans; I

1992
Treatment of malignant pleural effusions with doxorubicin hydrochloride-containing poly(L-lactic acid) microspheres.
    Chest, 1991, Volume: 99, Issue:4

    Topics: Aged; Breast Neoplasms; Chest Tubes; Delayed-Action Preparations; Doxorubicin; Drainage; Drug Carrie

1991
[Intracavitary microspheres incorporating cisplatinum in the treatment of malignant effusions--clinical trials].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1990, Volume: 17, Issue:8 Pt 2

    Topics: Animals; Ascitic Fluid; Cisplatin; Delayed-Action Preparations; Female; Humans; Infusions, Intraveno

1990
[The role of ascorbic acid in the combined preoperative preparation of cancer patients].
    Voprosy onkologii, 1989, Volume: 35, Issue:4

    Topics: Administration, Oral; Ascorbic Acid; Ascorbic Acid Deficiency; Combined Modality Therapy; Esophageal

1989
Diagnostic significance of pleural fluid lactate concentration in pleural and pulmonary diseases.
    Scandinavian journal of infectious diseases, 1988, Volume: 20, Issue:1

    Topics: Adolescent; Adult; Aged; Bacterial Infections; Child; Child, Preschool; Diagnosis, Differential; Hum

1988
Effect of lung resection on blood lactate threshold in lung cancer patients.
    European journal of applied physiology and occupational physiology, 1988, Volume: 57, Issue:4

    Topics: Anaerobiosis; Anthropometry; Body Surface Area; Differential Threshold; Humans; Lactates; Lactic Aci

1988
Exercise tolerance test in lung cancer patients: the relationship between exercise capacity and postthoracotomy hospital mortality.
    The Annals of thoracic surgery, 1987, Volume: 44, Issue:5

    Topics: Aged; Body Surface Area; Exercise Test; Humans; Lactates; Lactic Acid; Lung Neoplasms; Middle Aged;

1987