lactic acid has been researched along with Lung Neoplasms in 163 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Lung Neoplasms: Tumors or cancer of the LUNG.
| Excerpt | Relevance | Reference |
|---|---|---|
| " l-lactic acidosis, a common condition comprising high l-lactate concentration and acidic pH in the tumor microenvironment, has been known to induce tumor metastasis and drug resistance." | 8.12 | l-lactic acidosis confers insensitivity to PKC inhibitors by competing for uptake via monocarboxylate transporters. ( Chen, CH; Chen, CJ; Cheng, FJ; Chiou, JY; Huang, WC; Liu, YC; Nguyen, KTL; Shen, YC; Tang, CH; Tu, CY, 2022) |
| " Mutations in the tyrosine kinase epidermal growth factor receptor (EGFR) induce oncogenic addiction in lung adenocarcinoma (LAD)." | 7.80 | Epidermal growth factor receptor (EGFR) signaling regulates global metabolic pathways in EGFR-mutated lung adenocarcinoma. ( Esumi, H; Makinoshima, H; Matsumoto, S; Owada, S; Takita, M; Tsuchihara, K; Yagishita, A, 2014) |
| "Urethane is a recognized genotoxic carcinogen in fermented foods and beverages." | 5.43 | Lasting glycolytic stress governs susceptibility to urethane-induced lung carcinogenesis in vivo and in vitro. ( Cao, N; Deng, J; Du, G; Duan, Y; Geng, S; Guo, Z; Lin, H; Ma, X; Meng, M; Zheng, Y, 2016) |
| "Although pulmonary dosing of large porous particles has been shown to sustain drug delivery for a few days, there are no reports on safety or long term delivery." | 5.39 | Supercritical fluid technology based large porous celecoxib-PLGA microparticles do not induce pulmonary fibrosis and sustain drug delivery and efficacy for several weeks following a single dose. ( Dhanda, DS; Kompella, UB; Mirvish, SS; Tyagi, P, 2013) |
| "The melanoma cell metastasis to lungs was prevented by intravenous co-injection of B16BL6 melanoma cells with 1." | 5.33 | The effect of poly (aspartic acid-co-lactic acid) nanospheres on the lung metastasis of B16BL6 melanoma cells by intravenous administration. ( Hara, K; Huang, CC; Kawashima, Y; Mimura, H; Miwa, N; Tsujimoto, H, 2006) |
| " l-lactic acidosis, a common condition comprising high l-lactate concentration and acidic pH in the tumor microenvironment, has been known to induce tumor metastasis and drug resistance." | 4.12 | l-lactic acidosis confers insensitivity to PKC inhibitors by competing for uptake via monocarboxylate transporters. ( Chen, CH; Chen, CJ; Cheng, FJ; Chiou, JY; Huang, WC; Liu, YC; Nguyen, KTL; Shen, YC; Tang, CH; Tu, CY, 2022) |
| " Mutations in the tyrosine kinase epidermal growth factor receptor (EGFR) induce oncogenic addiction in lung adenocarcinoma (LAD)." | 3.80 | Epidermal growth factor receptor (EGFR) signaling regulates global metabolic pathways in EGFR-mutated lung adenocarcinoma. ( Esumi, H; Makinoshima, H; Matsumoto, S; Owada, S; Takita, M; Tsuchihara, K; Yagishita, A, 2014) |
| " The present study demonstrates that chitosan (CS)-modified PLGA NSs (CS-PLGA NSs) are preferentially taken up by human lung adenocarcinoma cells (A549)." | 3.75 | Improved cellular uptake of chitosan-modified PLGA nanospheres by A549 cells. ( Hirashima, N; Kawashima, Y; Sakai, T; Tahara, K; Takeuchi, H; Yamamoto, H, 2009) |
| "The aim of this study was to examine the effect of increased content of 45S5 Bioglass (0-40 wt%) in poly(dl-lactic acid) (PDLLA) porous foams on the behaviour of MG-63 (human osteosarcoma cell line) and A549 cells (human lung carcinoma cell line)." | 3.72 | PDLLA/Bioglass composites for soft-tissue and hard-tissue engineering: an in vitro cell biology assessment. ( Blaker, JJ; Boccaccini, AR; Hench, LL; Maquet, V; Verrier, S, 2004) |
| "Targeted-therapy failure in treating nonsmall cell lung cancer (NSCLC) frequently occurs because of the emergence of drug resistance and genetic mutations." | 2.72 | Potential therapeutics using tumor-secreted lactate in nonsmall cell lung cancer. ( Hsieh, CC; Kempson, IM; Liao, ZX; Tseng, SJ; Yang, PC, 2021) |
| "Radiation-induced lung injury (RILI) is a consequence of therapeutic thoracic irradiation (TR) for many cancers, and there are no FDA-approved curative strategies." | 1.91 | Exhaled breath condensate identifies metabolic dysregulation in patients with radiation-induced lung injury. ( Allegood, JC; Camus, SV; Cowart, LA; Freeberg, MAT; Jackson, PD; Liu, J; Pierre-Louis Odoom, J; Sanchez Rosado, RM; Silvey, S; Sime, PJ; Szomju, BB; Thatcher, TH; Toft, R; Weiss, E, 2023) |
| "Aspirin has been reported to promote apoptosis, inhibit proliferation, stemness, angiogenesis, cancer-associated inflammation and migration in NSCLC." | 1.72 | Aspirin blocks AMPK/SIRT3-mediated glycolysis to inhibit NSCLC cell proliferation. ( Li, G; Ma, Y; Ren, G; Wang, X; Zheng, Z, 2022) |
| "Patients with high-risk non-metastatic renal cell carcinoma (RCC) are at risk of metastatic relapse following nephrectomy." | 1.72 | Cabozantinib-Loaded PLGA Nanoparticles: A Potential Adjuvant Strategy for Surgically Resected High-Risk Non-Metastatic Renal Cell Carcinoma. ( Choy, YB; Kim, CR; Kim, SN; Lee, HW; Park, CG; Park, DH; Park, W; Seo, HS; Seo, SI; Yeom, SY, 2022) |
| "However, its role in breast cancer cell glucose metabolism was unclear." | 1.62 | Anti-Warburg effect by targeting HRD1-PFKP pathway may inhibit breast cancer progression. ( Fan, Y; Jin, F; Liang, X; Song, T; Su, D; Wang, J; Wang, Y; Xu, Y, 2021) |
| "Isovitexin (IVT) is a well-known flavone C-glycoside found in many plants and has attracted wide attention due to its obvious antitumor and antioxidant effects." | 1.62 | Isovitexin potentiated the antitumor activity of cisplatin by inhibiting the glucose metabolism of lung cancer cells and reduced cisplatin-induced immunotoxicity in mice. ( Chen, RL; He, JQ; Huang, P; Sun, CH; Wang, Z; Yu, CH; Yu, WY; Zhang, HH, 2021) |
| "Lung cancer is the leading cause of cancer death worldwide, and the carcinogens in tobacco smoke play a role in its progression and metastasis." | 1.62 | Cigarette smoke extract reduces FOXO3a promoting tumor progression and cell migration in lung cancer. ( Buscetta, M; Cipollina, C; Di Vincenzo, S; Ferraro, M; Pace, E; Sangiorgi, C, 2021) |
| "In the treatment of lung adenocarcinoma, targeting PFKFB3 would be a promising therapeutic strategy." | 1.48 | Expression of PFKFB3 and Ki67 in lung adenocarcinomas and targeting PFKFB3 as a therapeutic strategy. ( Ke, H; Li, X; Liu, J; Liu, Y; Qian, L; Tian, W; Yao, C; Zhang, J, 2018) |
| "Salinomycin sodium (SS) is an antibacterial therapeutic agent that exerts potent activity against CICs in various types of cancer, including lung cancer." | 1.48 | Promoted delivery of salinomycin sodium to lung cancer cells by dual targeting PLGA hybrid nanoparticles. ( Chen, H; Peng, Q; Sun, J; Zhou, J, 2018) |
| "Curcumin and Fe3O4 were encapsulated inside the PLGA-PEG co-polymer." | 1.46 | The Effects of Nanoencapsulated Curcumin-Fe3O4 on Proliferation and hTERT Gene Expression in Lung Cancer Cells. ( Akbarzadeh, A; Dariushnejad, H; Pilehvar-Soltanahmadi, Y; Sadeghzadeh, H; Sanjarian, F; Zarghami, N, 2017) |
| "Curcumin is a safe and efficient anticancer agent in this context, but its applications in cancer therapy are limited because of its hydrophobic structure and low solubility in water." | 1.43 | A comparison between PLGA-PEG and NIPAAm-MAA nanocarriers in curcumin delivery for hTERT silencing in lung cancer cell line. ( Badrzadeh, F; Roointan, A; Sharifi-Rad, J; Sharifi-Rad, M, 2016) |
| "Urethane is a recognized genotoxic carcinogen in fermented foods and beverages." | 1.43 | Lasting glycolytic stress governs susceptibility to urethane-induced lung carcinogenesis in vivo and in vitro. ( Cao, N; Deng, J; Du, G; Duan, Y; Geng, S; Guo, Z; Lin, H; Ma, X; Meng, M; Zheng, Y, 2016) |
| "Lung cancer is the major cause of cancer related lethality worldwide, and metastasis to distant organs is the pivotal cause of death for the vast majority of lung cancer patients." | 1.42 | Active targeting docetaxel-PLA nanoparticles eradicate circulating lung cancer stem-like cells and inhibit liver metastasis. ( Hou, C; Jiang, Y; Liu, Y; Sun, B; Yang, N; Zhang, H; Zheng, J; Zuo, P, 2015) |
| "Biphasic malignant pleural mesothelioma (MPM) is the second most common histotype of MPM." | 1.42 | Intracellular lactate-mediated induction of estrogen receptor beta (ERβ) in biphasic malignant pleural mesothelioma cells. ( Cilli, M; Daga, A; Manente, AG; Moro, L; Nilsson, S; Pinton, G; Rinaldi, M; Zonca, S, 2015) |
| "Radiotherapy is a key component of cancer treatment." | 1.42 | Improving DNA double-strand repair inhibitor KU55933 therapeutic index in cancer radiotherapy using nanoparticle drug delivery. ( Caster, JM; Foote, M; Hyder, SN; Lara, H; Saripalli, S; Sethi, M; Tian, X; Wagner, KT; Wang, AZ; Wang, E; Zhang, L, 2015) |
| "Cisplatin-resistant lung and ovarian cancer cell lines were used to evaluate the efficacy of metabolic inhibitors for selectively targeting cisplatin-resistant cells under varying oxygen conditions." | 1.40 | Targeting cisplatin-resistant human tumor cells with metabolic inhibitors. ( Brenneman, R; Kurtoglu, M; Lampidis, TJ; Liu, H; Sullivan, EJ, 2014) |
| "Although pulmonary dosing of large porous particles has been shown to sustain drug delivery for a few days, there are no reports on safety or long term delivery." | 1.39 | Supercritical fluid technology based large porous celecoxib-PLGA microparticles do not induce pulmonary fibrosis and sustain drug delivery and efficacy for several weeks following a single dose. ( Dhanda, DS; Kompella, UB; Mirvish, SS; Tyagi, P, 2013) |
| "As in ovarian cancer cells, increased metabolic activity and glucose concentration has been linked to aggressiveness of cancer." | 1.39 | Therapeutic role of EF24 targeting glucose transporter 1-mediated metabolism and metastasis in ovarian cancer cells. ( Ben, W; Dong, L; Guan, Y; Huang, Y; Lu, M; Ning, N; Wang, Y; Yang, Y; Yuan, J; Zhang, D, 2013) |
| " Furthermore, the synergism observed between TRAIL and doxorubicin suggests that the doxorubicin dosage could be substantially reduced and its side effects minimized." | 1.39 | Doxorubicin-loaded porous PLGA microparticles with surface attached TRAIL for the inhalation treatment of metastatic lung cancer. ( Byeon, HJ; Kim, I; Kim, TH; Lee, ES; Lee, KC; Oh, KT; Shin, BS; Youn, YS, 2013) |
| ") Thus, overall results suggest that nano-encapsulation of PD (NPD) increases drug bioavailability and thereby has a better chemo-preventive action against lung cancer in vivo and on A549 cells in vitro than that of PD." | 1.38 | Poly (lactide-co-glycolide) encapsulated extract of Phytolacca decandra demonstrates better intervention against induced lung adenocarcinoma in mice and on A549 cells. ( Bhadra, K; Das, J; Das, S; Khuda-Bukhsh, AR; Samadder, A, 2012) |
| "As a means of treating lymphatic metastasis from lung cancer, the pharmacokinetics and therapeutic effects of an intrapleural (ipl) implantable drug delivery system consisting of a gelatin sponge impregnated with polylactide-co-glycolide paclitaxel (PLGA-PTX) microspheres were studied." | 1.35 | Translymphatic chemotherapy by intrapleural placement of gelatin sponge containing biodegradable Paclitaxel colloids controls lymphatic metastasis in lung cancer. ( Johnston, MR; Kwong, E; Liu, J; Meisner, D; Wu, XY, 2009) |
| "In mice injected with B16 melanoma cells, the sustained IL-1Ra delivery from biodegradable microspheres inhibited tumor growth and significantly prolonged mice survival." | 1.34 | Sustained delivery of IL-1 Ra from biodegradable microspheres reduces the number of murine B16 melanoma lung metastases. ( Apte, RN; Cohen, S; Dinarello, CA; Lavi, G; Voronov, E, 2007) |
| "The melanoma cell metastasis to lungs was prevented by intravenous co-injection of B16BL6 melanoma cells with 1." | 1.33 | The effect of poly (aspartic acid-co-lactic acid) nanospheres on the lung metastasis of B16BL6 melanoma cells by intravenous administration. ( Hara, K; Huang, CC; Kawashima, Y; Mimura, H; Miwa, N; Tsujimoto, H, 2006) |
| "Clofazimine was shown to have a direct cytotoxic effect in vitro with an ID50 of 10." | 1.29 | Clofazimine alters the energy metabolism and inhibits the growth rate of a human lung-cancer cell line in vitro and in vivo. ( Fearon, KC; Plumb, JA; Sri-Pathmanathan, RM, 1994) |
| " Pharmacokinetic analysis showed that the initial tumor uptake of dFdC was flow limited, and a significant inverse correlation between the geometric FR and initial drug uptake was found." | 1.29 | Intratumor pharmacokinetics, flow resistance, and metabolism during gemcitabine infusion in ex vivo perfused human small cell lung cancer. ( Brown, TJ; Jain, RK; Kristjansen, PE; Shipley, LA, 1996) |
| "For the treatment of malignant pleural effusions, we prepared doxorubicin hydrochloride (Adriamycin)-containing poly(L-lactic acid) microspheres (ADR-MS)." | 1.28 | Treatment of malignant pleural effusions with doxorubicin hydrochloride-containing poly(L-lactic acid) microspheres. ( Hitomi, S; Ikada, Y; Ike, O; Shimizu, Y; Wada, R, 1991) |
| "A new dosage form of cisplatinum (CDDP), lactic acid oligomer microspheres incorporating cisplatinum (CDDP-ms), is designed to slowly release 70% of contained CDDP." | 1.28 | [Intracavitary microspheres incorporating cisplatinum in the treatment of malignant effusions--clinical trials]. ( Hagiwara, A; Ito, M; Iwamoto, A; Lee, M; Sasabe, T; Takahashi, T; Taniguchi, H; Wada, R; Yamaguchi, T; Yoneyama, C, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (4.29) | 18.7374 |
| 1990's | 7 (4.29) | 18.2507 |
| 2000's | 20 (12.27) | 29.6817 |
| 2010's | 92 (56.44) | 24.3611 |
| 2020's | 37 (22.70) | 2.80 |
| Authors | Studies |
|---|---|
| Nguyen, KTL | 1 |
| Chiou, JY | 1 |
| Liu, YC | 1 |
| Cheng, FJ | 1 |
| Shen, YC | 1 |
| Chen, CJ | 1 |
| Tang, CH | 1 |
| Huang, WC | 1 |
| Chen, CH | 1 |
| Tu, CY | 1 |
| Xie, M | 1 |
| Fu, XG | 1 |
| Jiang, K | 2 |
| Chen, W | 1 |
| Li, Q | 5 |
| Hou, R | 1 |
| Liang, H | 2 |
| Zhang, Y | 8 |
| Yang, Y | 3 |
| Gencer, A | 1 |
| Baysal, I | 1 |
| Nemutlu, E | 1 |
| Yabanoglu-Ciftci, S | 1 |
| Arica, B | 1 |
| Ren, G | 2 |
| Ma, Y | 1 |
| Wang, X | 3 |
| Zheng, Z | 1 |
| Li, G | 1 |
| Zhao, F | 1 |
| Wang, Z | 5 |
| Li, Z | 2 |
| Liu, S | 1 |
| Li, S | 4 |
| Lee, HW | 1 |
| Seo, HS | 1 |
| Yeom, SY | 1 |
| Kim, SN | 1 |
| Kim, CR | 1 |
| Park, DH | 1 |
| Park, W | 1 |
| Choy, YB | 1 |
| Park, CG | 1 |
| Seo, SI | 1 |
| Shang, S | 2 |
| Wang, MZ | 2 |
| Xing, Z | 2 |
| He, N | 2 |
| Li, J | 3 |
| Wu, Z | 5 |
| Chen, G | 1 |
| Zhu, X | 1 |
| Zhang, R | 2 |
| Wu, W | 1 |
| Zhu, Y | 2 |
| Ma, L | 1 |
| Yu, H | 1 |
| Hao, D | 1 |
| Li, Y | 1 |
| Shi, J | 2 |
| Jiang, J | 2 |
| Liu, B | 1 |
| Zhang, J | 9 |
| Meng, X | 1 |
| Xie, SM | 1 |
| Liu, F | 2 |
| Chen, H | 2 |
| Yao, D | 1 |
| Li, M | 2 |
| Guo, M | 1 |
| Shen, H | 2 |
| Zhang, X | 2 |
| Xing, L | 1 |
| Liu, X | 2 |
| Qin, H | 1 |
| Zhang, L | 8 |
| Jia, C | 1 |
| Chao, Z | 1 |
| Qin, X | 1 |
| Zhang, H | 2 |
| Chen, C | 3 |
| Guo, Z | 2 |
| Hu, L | 1 |
| Wang, Q | 1 |
| Wang, Y | 7 |
| Liu, XP | 1 |
| Hu, W | 1 |
| Silva, A | 1 |
| Cerqueira, MC | 1 |
| Rosa, B | 1 |
| Sobral, C | 1 |
| Pinto-Ribeiro, F | 1 |
| Costa, MF | 1 |
| Baltazar, F | 2 |
| Afonso, J | 1 |
| Chen, WJ | 1 |
| Huang, SY | 1 |
| Chen, YW | 1 |
| Liu, YF | 1 |
| Huang, RS | 1 |
| Pierre-Louis Odoom, J | 1 |
| Freeberg, MAT | 1 |
| Camus, SV | 1 |
| Toft, R | 1 |
| Szomju, BB | 1 |
| Sanchez Rosado, RM | 1 |
| Jackson, PD | 1 |
| Allegood, JC | 1 |
| Silvey, S | 1 |
| Liu, J | 3 |
| Cowart, LA | 1 |
| Weiss, E | 1 |
| Thatcher, TH | 1 |
| Sime, PJ | 1 |
| Chen, Z | 2 |
| Song, Y | 1 |
| Li, P | 1 |
| Gao, W | 1 |
| Seelbinder, B | 1 |
| Lohinai, Z | 1 |
| Vazquez-Uribe, R | 1 |
| Brunke, S | 1 |
| Chen, X | 5 |
| Mirhakkak, M | 1 |
| Lopez-Escalera, S | 1 |
| Dome, B | 1 |
| Megyesfalvi, Z | 1 |
| Berta, J | 1 |
| Galffy, G | 1 |
| Dulka, E | 1 |
| Wellejus, A | 1 |
| Weiss, GJ | 1 |
| Bauer, M | 1 |
| Hube, B | 1 |
| Sommer, MOA | 1 |
| Panagiotou, G | 1 |
| Tong, Z | 1 |
| Tong, C | 1 |
| Wu, L | 1 |
| Xu, L | 1 |
| Li, K | 1 |
| Xu, F | 1 |
| Liang, S | 1 |
| Kong, Y | 1 |
| Chen, B | 1 |
| Wang, M | 2 |
| He, T | 1 |
| Meng, D | 1 |
| Lv, W | 1 |
| Ye, J | 1 |
| Cheng, L | 1 |
| Hu, J | 2 |
| Li, W | 2 |
| Huang, X | 1 |
| Feng, D | 1 |
| Zou, X | 1 |
| Zhou, Y | 1 |
| Xie, Q | 1 |
| Zhu, Z | 2 |
| He, Y | 2 |
| Zhang, Z | 4 |
| Luo, J | 2 |
| Peng, T | 1 |
| Cheng, F | 1 |
| Gao, J | 1 |
| Cao, Y | 4 |
| Wei, H | 4 |
| Singh, S | 1 |
| Pandey, S | 1 |
| Chawla, AS | 1 |
| Bhatt, AN | 1 |
| Roy, BG | 1 |
| Saluja, D | 1 |
| Dwarakanath, BS | 1 |
| Huang, T | 1 |
| Zhou, X | 3 |
| Mao, X | 1 |
| Yu, C | 1 |
| Yang, J | 4 |
| Su, T | 1 |
| Malviya, N | 1 |
| Sonkar, C | 1 |
| Ganguly, R | 1 |
| Bhattacherjee, D | 1 |
| Bhabak, KP | 1 |
| Mukhopadhyay, S | 1 |
| Yuan, Y | 2 |
| Sun, L | 1 |
| Chen, J | 2 |
| Jia, M | 1 |
| Zou, Y | 1 |
| Sa, H | 1 |
| Cai, Y | 2 |
| Xu, Y | 2 |
| Sun, C | 1 |
| Guo, Y | 2 |
| Li, H | 4 |
| Ma, K | 1 |
| Murray, PJ | 1 |
| Hu, M | 1 |
| Zhao, Y | 2 |
| Tang, Q | 1 |
| Feng, Z | 1 |
| Ni, J | 1 |
| Flint, LE | 1 |
| Hamm, G | 1 |
| Ready, JD | 1 |
| Ling, S | 1 |
| Duckett, CJ | 1 |
| Cross, NA | 1 |
| Cole, LM | 1 |
| Smith, DP | 1 |
| Goodwin, RJA | 1 |
| Clench, MR | 1 |
| Chen, S | 2 |
| Yang, X | 2 |
| Xie, B | 1 |
| Guo, J | 4 |
| Wang, C | 4 |
| Wang, K | 1 |
| Huang, W | 1 |
| Chen, R | 1 |
| Lin, P | 1 |
| Zhang, T | 1 |
| Ni, YF | 1 |
| Wu, J | 3 |
| Sun, XX | 1 |
| Geng, JJ | 1 |
| Zhu, YM | 1 |
| Nan, G | 1 |
| Zhang, W | 2 |
| Zhu, P | 1 |
| Bian, H | 1 |
| Chen, ZN | 1 |
| Fan, Y | 1 |
| Wang, J | 3 |
| Song, T | 1 |
| Liang, X | 1 |
| Jin, F | 2 |
| Su, D | 1 |
| Chen, RL | 1 |
| Huang, P | 2 |
| Sun, CH | 1 |
| Yu, WY | 1 |
| Zhang, HH | 1 |
| Yu, CH | 1 |
| He, JQ | 1 |
| Di Vincenzo, S | 1 |
| Sangiorgi, C | 1 |
| Ferraro, M | 1 |
| Buscetta, M | 1 |
| Cipollina, C | 1 |
| Pace, E | 1 |
| Yuan, Q | 2 |
| Cao, X | 2 |
| Cao, J | 2 |
| Xia, L | 1 |
| Xiong, B | 1 |
| Chen, Y | 3 |
| Liu, Y | 5 |
| Hu, X | 1 |
| Han, H | 4 |
| Ghergurovich, JM | 1 |
| Lang, JD | 1 |
| Levin, MK | 1 |
| Briones, N | 1 |
| Facista, SJ | 1 |
| Mueller, C | 1 |
| Cowan, AJ | 1 |
| McBride, MJ | 1 |
| Rodriguez, ESR | 1 |
| Killian, A | 1 |
| Dao, T | 1 |
| Lamont, J | 1 |
| Barron, A | 1 |
| Su, X | 1 |
| Hendricks, WPD | 1 |
| Espina, V | 1 |
| Von Hoff, DD | 1 |
| O'Shaughnessy, J | 1 |
| Rabinowitz, JD | 1 |
| Chang, H | 1 |
| Xu, Q | 1 |
| Ma, H | 1 |
| Liao, ZX | 2 |
| Kempson, IM | 2 |
| Hsieh, CC | 1 |
| Tseng, SJ | 2 |
| Yang, PC | 2 |
| Ziaei, E | 1 |
| Emami, J | 1 |
| Rezazadeh, M | 1 |
| Kazemi, M | 1 |
| Feng, J | 1 |
| Yang, H | 1 |
| Zhu, B | 2 |
| Yang, M | 2 |
| Cao, W | 1 |
| Wang, L | 1 |
| Faubert, B | 1 |
| Li, KY | 1 |
| Cai, L | 1 |
| Hensley, CT | 1 |
| Kim, J | 1 |
| Zacharias, LG | 1 |
| Yang, C | 2 |
| Do, QN | 1 |
| Doucette, S | 1 |
| Burguete, D | 1 |
| Huet, G | 1 |
| Wigal, T | 1 |
| Butt, Y | 1 |
| Ni, M | 1 |
| Torrealba, J | 1 |
| Oliver, D | 1 |
| Lenkinski, RE | 1 |
| Malloy, CR | 1 |
| Wachsmann, JW | 1 |
| Young, JD | 1 |
| Kernstine, K | 1 |
| DeBerardinis, RJ | 2 |
| Khan, MN | 1 |
| Haggag, YA | 1 |
| Lane, ME | 1 |
| McCarron, PA | 1 |
| Tambuwala, MM | 1 |
| Li, X | 2 |
| Qian, L | 1 |
| Ke, H | 1 |
| Yao, C | 1 |
| Tian, W | 1 |
| Caronni, N | 1 |
| Simoncello, F | 1 |
| Stafetta, F | 1 |
| Guarnaccia, C | 1 |
| Ruiz-Moreno, JS | 1 |
| Opitz, B | 1 |
| Galli, T | 1 |
| Proux-Gillardeaux, V | 1 |
| Benvenuti, F | 1 |
| Patel, J | 1 |
| Amrutiya, J | 1 |
| Bhatt, P | 1 |
| Javia, A | 1 |
| Jain, M | 1 |
| Misra, A | 1 |
| Jiang, W | 1 |
| Wang, H | 3 |
| Cui, Y | 1 |
| Lei, Y | 1 |
| Xu, D | 1 |
| Jiang, N | 1 |
| Sun, Y | 1 |
| Ke, Z | 1 |
| Ignjatović, NL | 1 |
| Penov-Gaši, KM | 1 |
| Ajduković, JJ | 1 |
| Kojić, VV | 1 |
| Marković, SB | 1 |
| Uskoković, DP | 1 |
| Wang, W | 4 |
| Pan, G | 1 |
| Yi, Q | 1 |
| Zhong, W | 1 |
| Yan, D | 1 |
| Zhou, J | 1 |
| Sun, J | 1 |
| Peng, Q | 1 |
| Apicella, M | 1 |
| Giannoni, E | 1 |
| Fiore, S | 1 |
| Ferrari, KJ | 1 |
| Fernández-Pérez, D | 1 |
| Isella, C | 1 |
| Granchi, C | 1 |
| Minutolo, F | 1 |
| Sottile, A | 1 |
| Comoglio, PM | 1 |
| Medico, E | 1 |
| Pietrantonio, F | 1 |
| Volante, M | 1 |
| Pasini, D | 1 |
| Chiarugi, P | 1 |
| Giordano, S | 1 |
| Corso, S | 1 |
| Huang, KY | 1 |
| Li, HJ | 1 |
| Fa, YC | 1 |
| Ho, YC | 1 |
| Liu, N | 1 |
| Kuang, D | 1 |
| Xu, S | 1 |
| Duan, Y | 2 |
| Xia, Y | 1 |
| Wei, Z | 1 |
| Xie, X | 1 |
| Yin, B | 1 |
| Chen, F | 1 |
| Luo, S | 1 |
| Liu, H | 3 |
| Gong, F | 1 |
| Tang, ZH | 1 |
| Cheng, X | 2 |
| Laurence, A | 1 |
| Wang, G | 2 |
| Yang, XP | 1 |
| Updegraff, BL | 1 |
| Padanad, MS | 1 |
| Chen, PH | 1 |
| Sudderth, J | 1 |
| Rodriguez-Tirado, C | 1 |
| Girard, L | 1 |
| Minna, JD | 1 |
| Mishra, P | 1 |
| O'Donnell, KA | 1 |
| Yu, B | 1 |
| Wu, Y | 1 |
| Huang, B | 1 |
| Liu, CS | 1 |
| Dhanda, DS | 1 |
| Tyagi, P | 1 |
| Mirvish, SS | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pilot Study To Investigate Targetable Metabolic Pathways Sustaining Triple Negative (TN) Breast Cancer and Associated Genomic Alterations[NCT03457779] | 16 participants (Actual) | Interventional | 2018-02-08 | Completed | |||
| 18F-FDG Metabolism Imaging Monitoring Non-small Cell Lung Cancer Curative Effect of Chemotherapy Multicenter Clinical Study[NCT02938546] | Phase 3 | 200 participants (Anticipated) | Interventional | 2016-11-30 | Not yet recruiting | ||
| The Role of Pyruvate Kinase M2 in Growth, Invasion and Drug Resistance in Human Urothelial Carcinoma[NCT01968928] | 25 participants (Anticipated) | Observational [Patient Registry] | 2014-01-31 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for lactic acid and Lung Neoplasms
| Article | Year |
|---|---|
Prognostic Value of Monocarboxylate Transporter 1 Overexpression in Cancer: A Systematic Review.
Topics: Carcinoma, Non-Small-Cell Lung; Humans; Lactic Acid; Lung Neoplasms; Monocarboxylic Acid Transporter | 2023 |
On macrophage diversity and inflammatory metabolic timers.
Topics: Animals; Gene Expression; Gene Expression Profiling; Humans; Inflammation; Lactic Acid; Lung Neoplas | 2020 |
Potential therapeutics using tumor-secreted lactate in nonsmall cell lung cancer.
Topics: Anaplastic Lymphoma Kinase; Animals; Carcinoma, Non-Small-Cell Lung; Citric Acid Cycle; Drug Resista | 2021 |
Safety and outcome of treatment of metastatic melanoma using 3-bromopyruvate: a concise literature review and case study.
Topics: Acetaminophen; Adult; Carcinoma, Hepatocellular; Disease Progression; Drug Therapy, Combination; Enz | 2014 |
3 trials available for lactic acid and Lung Neoplasms
| Article | Year |
|---|---|
Local production of lactate, ribose phosphate, and amino acids within human triple-negative breast cancer.
Topics: Amino Acids; Carcinoma, Non-Small-Cell Lung; Glucose; Humans; Lactic Acid; Lung Neoplasms; Proteomic | 2021 |
Elevated lactic acid is a negative prognostic factor in metastatic lung cancer.
Topics: Adenocarcinoma; Aged; Aged, 80 and over; Biomarkers, Tumor; Carcinoma, Large Cell; Carcinoma, Non-Sm | 2015 |
Glucose-induced thermogenesis in patients with small cell lung carcinoma. The effect of acute beta-adrenergic inhibition.
Topics: Aged; Blood Flow Velocity; Blood Glucose; Blood Pressure; Carcinoma, Small Cell; Catecholamines; Ene | 1994 |
156 other studies available for lactic acid and Lung Neoplasms
| Article | Year |
|---|---|
l-lactic acidosis confers insensitivity to PKC inhibitors by competing for uptake via monocarboxylate transporters.
Topics: Acidosis, Lactic; Carcinoma, Non-Small-Cell Lung; ErbB Receptors; Humans; Lactic Acid; Lung Neoplasm | 2022 |
Notch1/TAZ axis promotes aerobic glycolysis and immune escape in lung cancer.
Topics: Aerobiosis; Animals; Cell Line, Tumor; Feedback, Physiological; Gene Expression Regulation, Neoplast | 2021 |
An integrated metabonomics study to reveal the inhibitory effect and metabolism regulation of taurine on breast cancer.
Topics: Animals; Arginine; Breast Neoplasms; Choline; Female; Glutamic Acid; Histidine; Humans; Isoleucine; | 2022 |
Efficacy of siRNA-loaded nanoparticles in the treatment of K-RAS mutant lung cancer
Topics: Humans; Lactic Acid; Lung Neoplasms; Nanoparticles; Particle Size; Polylactic Acid-Polyglycolic Acid | 2022 |
Aspirin blocks AMPK/SIRT3-mediated glycolysis to inhibit NSCLC cell proliferation.
Topics: AMP-Activated Protein Kinases; Aspirin; Carcinoma, Non-Small-Cell Lung; Cell Proliferation; Glycolys | 2022 |
Identifying a lactic acid metabolism-related gene signature contributes to predicting prognosis, immunotherapy efficacy, and tumor microenvironment of lung adenocarcinoma.
Topics: Adenocarcinoma of Lung; Erlotinib Hydrochloride; Etoposide; Gefitinib; Humans; Immunologic Factors; | 2022 |
Cabozantinib-Loaded PLGA Nanoparticles: A Potential Adjuvant Strategy for Surgically Resected High-Risk Non-Metastatic Renal Cell Carcinoma.
Topics: Animals; Carcinoma, Renal Cell; Drug Carriers; Emulsions; Humans; Kidney Neoplasms; Lactic Acid; Lun | 2022 |
Lactate regulators contribute to tumor microenvironment and predict prognosis in lung adenocarcinoma.
Topics: Adenocarcinoma of Lung; Humans; Lactic Acid; Lung Neoplasms; Programmed Cell Death 1 Receptor; Tumor | 2022 |
Lactate regulators contribute to tumor microenvironment and predict prognosis in lung adenocarcinoma.
Topics: Adenocarcinoma of Lung; Humans; Lactic Acid; Lung Neoplasms; Programmed Cell Death 1 Receptor; Tumor | 2022 |
Lactate regulators contribute to tumor microenvironment and predict prognosis in lung adenocarcinoma.
Topics: Adenocarcinoma of Lung; Humans; Lactic Acid; Lung Neoplasms; Programmed Cell Death 1 Receptor; Tumor | 2022 |
Lactate regulators contribute to tumor microenvironment and predict prognosis in lung adenocarcinoma.
Topics: Adenocarcinoma of Lung; Humans; Lactic Acid; Lung Neoplasms; Programmed Cell Death 1 Receptor; Tumor | 2022 |
Formosanin C inhibits non-small-cell lung cancer progression by blocking MCT4/CD147-mediated lactate export.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Diosgenin; Humans; Lactic Acid | 2023 |
Circ_0110498 facilitates the cisplatin resistance of non-small cell lung cancer by mediating the miR-1287-5p/RBBP4 axis.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cisplatin; Drug Resistance, Ne | 2023 |
HDAC6-G3BP2 promotes lysosomal-TSC2 and suppresses mTORC1 under ETV4 targeting-induced low-lactate stress in non-small cell lung cancer.
Topics: Adaptor Proteins, Signal Transducing; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Histone Deac | 2023 |
Hyperoxia induces glucose metabolism reprogramming and intracellular acidification by suppressing MYC/MCT1 axis in lung cancer.
Topics: Cell Line, Tumor; Glucose; Humans; Hydrogen-Ion Concentration; Hyperoxia; Lactic Acid; Lung Neoplasm | 2023 |
Molecular Characterization and Prognosis of Lactate-Related Genes in Lung Adenocarcinoma.
Topics: Adenocarcinoma of Lung; DNA Copy Number Variations; Humans; Lactic Acid; Lung Neoplasms; Prognosis; | 2023 |
Dietary Folate Deficiency Promotes Lactate Metabolic Disorders to Sensitize Lung Cancer Metastasis through MTOR-Signaling-Mediated Druggable Oncotargets.
Topics: Animals; Diet; Folic Acid; Folic Acid Deficiency; L-Lactate Dehydrogenase; Lactic Acid; Lung Neoplas | 2023 |
Exhaled breath condensate identifies metabolic dysregulation in patients with radiation-induced lung injury.
Topics: Biomarkers; Breath Tests; Humans; Idiopathic Pulmonary Fibrosis; Lactic Acid; Lung; Lung Injury; Lun | 2023 |
GRIN2D knockdown suppresses the progression of lung adenocarcinoma by regulating the E2F signalling pathway.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Cell Proliferation; Gene Expression Regulation, Neoplastic; | 2023 |
Candida expansion in the gut of lung cancer patients associates with an ecological signature that supports growth under dysbiotic conditions.
Topics: Candida; Cross-Sectional Studies; Dysbiosis; Female; Humans; Lactic Acid; Lung Neoplasms; Male | 2023 |
A novel molecular mechanism mediated by circCCDC134 regulates non-small cell lung cancer progression.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cell Proliferation; Exosomes; Humans; Lactic Acid; Lung Neo | 2023 |
M2 macrophage exosomal LINC01001 promotes non-small cell lung cancer development by affecting METTL3 and glycolysis pathway.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Glycolysis; Lactic Acid; Lung Neoplasms; Macrophages; Mice | 2023 |
BZW2 Modulates Lung Adenocarcinoma Progression through Glycolysis-Mediated IDH3G Lactylation Modification.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Cell Line, Tumor; Cell Proliferation; Gene Expressi | 2023 |
A Case of Lung Involvement in Peripheral T Cell Lymphoma.
Topics: Acidosis, Lactic; Adult; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Cyclophosphamide; D | 2019 |
A lactate-induced Snail/STAT3 pathway drives GPR81 expression in lung cancer cells.
Topics: A549 Cells; Cell Line, Tumor; Disease Progression; Humans; Lactic Acid; Lung Neoplasms; Receptors, G | 2020 |
Dietary 2-deoxy-D-glucose impairs tumour growth and metastasis by inhibiting angiogenesis.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Angiogenesis Inhibitors; Animals; Antimetabolites; Ca | 2019 |
Lactate-fueled oxidative metabolism drives DNA methyltransferase 1-mediated transcriptional co-activator with PDZ binding domain protein activation.
Topics: Cell Line, Tumor; DNA (Cytosine-5-)-Methyltransferase 1; Glycogen Synthase Kinase 3 beta; Humans; In | 2020 |
Novel Approach to Generate a Self-Deliverable Ru(II)-Based Anticancer Agent in the Self-Reacting Confined Gel Space.
Topics: A549 Cells; Antineoplastic Agents; Apoptosis; Cell Proliferation; Coordination Complexes; Dimethyl S | 2019 |
Identification of a new
Topics: Alternative Splicing; Animals; Base Sequence; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferat | 2019 |
DRP1 promotes lactate utilization in KRAS-mutant non-small-cell lung cancer cells.
Topics: A549 Cells; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Death; Cell Line, Tumor; Cell Proliferat | 2020 |
Characterization of an Aggregated Three-Dimensional Cell Culture Model by Multimodal Mass Spectrometry Imaging.
Topics: Adenocarcinoma of Lung; Citric Acid; Glutamine; Humans; Lactic Acid; Lung Neoplasms; Multimodal Imag | 2020 |
Inhalable functional mixed-polymer microspheres to enhance doxorubicin release behavior for lung cancer treatment.
Topics: Animals; Doxorubicin; Lactic Acid; Lung; Lung Neoplasms; Mice; Mice, Inbred BALB C; Microspheres; Pa | 2020 |
Di-methylation of CD147-K234 Promotes the Progression of NSCLC by Enhancing Lactate Export.
Topics: Animals; Basigin; Carcinoma, Non-Small-Cell Lung; Cell Line; Humans; Lactic Acid; Lung Neoplasms; Ma | 2021 |
Anti-Warburg effect by targeting HRD1-PFKP pathway may inhibit breast cancer progression.
Topics: Adenosine Triphosphate; Animals; Breast Neoplasms; Cell Line; Cell Movement; Cell Proliferation; Dis | 2021 |
Isovitexin potentiated the antitumor activity of cisplatin by inhibiting the glucose metabolism of lung cancer cells and reduced cisplatin-induced immunotoxicity in mice.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Apigenin; Carcinoma, Non-Small-Cell Lung; Ca | 2021 |
Cigarette smoke extract reduces FOXO3a promoting tumor progression and cell migration in lung cancer.
Topics: A549 Cells; Cell Line, Tumor; Cell Movement; Disease Progression; Down-Regulation; Forkhead Box Prot | 2021 |
Isovitexin Suppresses Stemness of Lung Cancer Stem-Like Cells through Blockage of MnSOD/CaMKII/AMPK Signaling and Glycolysis Inhibition.
Topics: A549 Cells; Adenylate Kinase; Animals; Apigenin; Calcium-Calmodulin-Dependent Protein Kinase Type 2; | 2021 |
Artesunate-loaded porous PLGA microsphere as a pulmonary delivery system for the treatment of non-small cell lung cancer.
Topics: Artesunate; Carcinoma, Non-Small-Cell Lung; Humans; Lactic Acid; Lung Neoplasms; Microspheres; Parti | 2021 |
Lactate secreted by PKM2 upregulation promotes Galectin-9-mediated immunosuppression via inhibiting NF-κB pathway in HNSCC.
Topics: Base Sequence; Carrier Proteins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Galectins; Gen | 2021 |
Pulmonary Delivery of Docetaxel and Celecoxib by PLGA Porous Microparticles for Their Synergistic Effects Against Lung Cancer.
Topics: Celecoxib; Docetaxel; Drug Carriers; Humans; Lactic Acid; Lung Neoplasms; Particle Size; Porosity | 2022 |
Tumor cell-derived lactate induces TAZ-dependent upregulation of PD-L1 through GPR81 in human lung cancer cells.
Topics: Apoptosis; B7-H1 Antigen; Cell Line, Tumor; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Gene E | 2017 |
Lactate Metabolism in Human Lung Tumors.
Topics: Animals; Blood Chemical Analysis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Citric Acid Cycl | 2017 |
Polymeric Nano-Encapsulation of Curcumin Enhances its Anti-Cancer Activity in Breast (MDA-MB231) and Lung (A549) Cancer Cells Through Reduction in Expression of HIF-1α and Nuclear p65 (Rel A).
Topics: A549 Cells; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Curcumin; Drug Carriers; Huma | 2018 |
Expression of PFKFB3 and Ki67 in lung adenocarcinomas and targeting PFKFB3 as a therapeutic strategy.
Topics: A549 Cells; Adenocarcinoma; Adenocarcinoma of Lung; Adult; Aged; Aged, 80 and over; Apoptosis; Bioma | 2018 |
Downregulation of Membrane Trafficking Proteins and Lactate Conditioning Determine Loss of Dendritic Cell Function in Lung Cancer.
Topics: Animals; Antigen Presentation; Antigens, Neoplasm; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Cul | 2018 |
Upregulation of lactate-inducible snail protein suppresses oncogene-mediated senescence through p16
Topics: Alveolar Epithelial Cells; Animals; Cell Line, Tumor; Cellular Senescence; Cyclin-Dependent Kinase I | 2018 |
Targeted delivery of monoclonal antibody conjugated docetaxel loaded PLGA nanoparticles into EGFR overexpressed lung tumour cells.
Topics: A549 Cells; Animals; Antineoplastic Agents; Apoptosis; Cetuximab; Docetaxel; Drug Carriers; Drug Del | 2018 |
Polymer nanofiber-based microchips for EGFR mutation analysis of circulating tumor cells in lung adenocarcinoma.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Base Sequence; Carcinoma, Non-Small-Cell Lung; Cell Count; C | 2018 |
The effect of the androstane lung cancer inhibitor content on the cell-selective toxicity of hydroxyapatite-chitosan-PLGA nanocomposites.
Topics: A549 Cells; Androstanes; Calorimetry, Differential Scanning; Cell Line; Cell Survival; Chitosan; Dru | 2018 |
MiR-182 promotes glucose metabolism by upregulating hypoxia-inducible factor 1α in NSCLC cells.
Topics: 3' Untranslated Regions; Carcinoma, Non-Small-Cell Lung; Cell Hypoxia; Cell Line, Tumor; Cell Prolif | 2018 |
MicroRNA-31-5p enhances the Warburg effect via targeting FIH.
Topics: Animals; Apoptosis; Cell Proliferation; Gene Expression Regulation, Neoplastic; Glycolysis; Humans; | 2019 |
Promoted delivery of salinomycin sodium to lung cancer cells by dual targeting PLGA hybrid nanoparticles.
Topics: AC133 Antigen; Animals; Antibiotics, Antineoplastic; Cell Line, Tumor; Drug Delivery Systems; ErbB R | 2018 |
Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies.
Topics: Animals; Antineoplastic Agents; Cancer-Associated Fibroblasts; Cell Line, Tumor; Cell Transformation | 2018 |
Targeting Tumor Microenvironment by Bioreduction-Activated Nanoparticles for Light-Triggered Virotherapy.
Topics: Animals; Antineoplastic Agents; Cell Proliferation; Cells, Cultured; Dependovirus; HEK293 Cells; Hum | 2018 |
Lactate inhibits ATP6V0d2 expression in tumor-associated macrophages to promote HIF-2α-mediated tumor progression.
Topics: Adenocarcinoma of Lung; Animals; Basic Helix-Loop-Helix Transcription Factors; Female; Gene Expressi | 2019 |
Transmembrane Protease TMPRSS11B Promotes Lung Cancer Growth by Enhancing Lactate Export and Glycolytic Metabolism.
Topics: Basigin; Biological Transport; Carcinogenesis; Cell Line, Tumor; Cell Membrane; Cell Proliferation; | 2018 |
Controlled preparation and antitumor efficacy of vitamin E TPGS-functionalized PLGA nanoparticles for delivery of paclitaxel.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Chemical Precipitation; Delayed-Action | 2013 |
Supercritical fluid technology based large porous celecoxib-PLGA microparticles do not induce pulmonary fibrosis and sustain drug delivery and efficacy for several weeks following a single dose.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzo(a)pyrene; Bron | 2013 |
Microencapsulation of alpha-mangostin into PLGA microspheres and optimization using response surface methodology intended for pulmonary delivery.
Topics: Administration, Inhalation; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Drug Carriers; Drug Co | 2013 |
Effects of chemically modified nanostructured PLGA on functioning of lung and breast cancer cells.
Topics: Alginates; Analysis of Variance; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Pro | 2013 |
Doxorubicin-loaded porous PLGA microparticles with surface attached TRAIL for the inhalation treatment of metastatic lung cancer.
Topics: Administration, Inhalation; Animals; Antibiotics, Antineoplastic; Cell Line, Tumor; Delayed-Action P | 2013 |
Relationships between LDH-A, lactate, and metastases in 4T1 breast tumors.
Topics: Adenosine Triphosphate; Animals; Breast Neoplasms; Cell Adhesion; Cell Movement; Cell Proliferation; | 2013 |
Antibody conjugated PLGA nanoparticles for targeted delivery of paclitaxel palmitate: efficacy and biofate in a lung cancer mouse model.
Topics: Amides; Animals; Antibodies; Antibodies, Monoclonal, Humanized; Area Under Curve; Cell Line, Tumor; | 2013 |
[Study on the anti-Lewis lung carcinoma effect of metformin combined with MCT1 inhibitor CHC].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Lewis Lung; Coumaric | 2013 |
Therapeutic role of EF24 targeting glucose transporter 1-mediated metabolism and metastasis in ovarian cancer cells.
Topics: Animals; Benzylidene Compounds; Biological Transport; Cell Line, Tumor; Cell Movement; Cell Prolifer | 2013 |
Activity of the monocarboxylate transporter 1 inhibitor AZD3965 in small cell lung cancer.
Topics: Adult; Aged; Aged, 80 and over; Animals; Antineoplastic Agents; Cell Death; Cell Line, Tumor; Drug R | 2014 |
Magnetic resonance imaging of tumor glycolysis using hyperpolarized 13C-labeled glucose.
Topics: Animals; Carbon Isotopes; Glucose; Glycolysis; Lactic Acid; Lung Neoplasms; Lymphoma; Magnetic Reson | 2014 |
Targeting cisplatin-resistant human tumor cells with metabolic inhibitors.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cisplatin; Deoxyglucose; Drug Resistance, Neoplasm; Female; | 2014 |
HIF-1-mediated metabolic reprogramming reduces ROS levels and facilitates the metastatic colonization of cancers in lungs.
Topics: Anaerobiosis; Animals; Female; Glucose; Glycolysis; Hypoxia-Inducible Factor 1; Immunoenzyme Techniq | 2014 |
Preparation of lung-targeting, emodin-loaded polylactic acid microspheres and their properties.
Topics: Animals; Drug Carriers; Emodin; Gelatin; Injections, Intravenous; Lactic Acid; Lung Diseases; Lung N | 2014 |
An NMR metabolomics approach for the diagnosis of leptomeningeal carcinomatosis in lung adenocarcinoma cancer patients.
Topics: Adenocarcinoma; Alanine; Area Under Curve; Biomarkers, Tumor; Case-Control Studies; Citric Acid; Cre | 2015 |
Epidermal growth factor receptor (EGFR) signaling regulates global metabolic pathways in EGFR-mutated lung adenocarcinoma.
Topics: Adenocarcinoma; Aspartate Carbamoyltransferase; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing) | 2014 |
Combination of doxorubicin-based chemotherapy and polyethylenimine/p53 gene therapy for the treatment of lung cancer using porous PLGA microparticles.
Topics: Antibiotics, Antineoplastic; Cell Line, Tumor; Doxorubicin; Flow Cytometry; Genes, p53; Genetic Ther | 2014 |
A computational study of the Warburg effect identifies metabolic targets inhibiting cancer migration.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Computational Biology; Gene S | 2014 |
Synthesis and in vitro study of cisplatin-loaded Fe3O4 nanoparticles modified with PLGA-PEG6000 copolymers in treatment of lung cancer.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cisplatin; Drug Screening Assays, Antitumor; Ferric Compoun | 2014 |
Targeted delivery of doxorubicin to A549 lung cancer cells by CXCR4 antagonist conjugated PLGA nanoparticles.
Topics: Antibiotics, Antineoplastic; Cell Line, Tumor; Doxorubicin; Humans; Lactic Acid; Lung Neoplasms; Mic | 2014 |
A therapeutic microparticle-based tumor lysate vaccine reduces spontaneous metastases in murine breast cancer.
Topics: Animals; Antigens, Neoplasm; Autoimmunity; Biocompatible Materials; Cancer Vaccines; CD8-Positive T- | 2014 |
Synergistic co-delivery of doxorubicin and paclitaxel by porous PLGA microspheres for pulmonary inhalation treatment.
Topics: Administration, Inhalation; Animals; Antineoplastic Agents; Doxorubicin; Drug Carriers; Drug Deliver | 2014 |
Active targeting docetaxel-PLA nanoparticles eradicate circulating lung cancer stem-like cells and inhibit liver metastasis.
Topics: AC133 Antigen; Animals; Antigens, CD; Antineoplastic Agents; Body Weight; Cell Line, Tumor; Docetaxe | 2015 |
Targeted delivery of a sialic acid-blocking glycomimetic to cancer cells inhibits metastatic spread.
Topics: Animals; Antibodies; Biomimetic Materials; Drug Carriers; Female; Lactic Acid; Lung Neoplasms; Melan | 2015 |
Glycosaminoglycan-functionalized poly-lactide-co-glycolide nanoparticles: synthesis, characterization, cytocompatibility, and cellular uptake.
Topics: Cell Proliferation; Cells, Cultured; Endothelium, Vascular; Glycosaminoglycans; Humans; Kidney Tubul | 2015 |
Ets1 identified as a novel molecular target of RNA aptamer selected against metastatic cells for targeted delivery of nano-formulation.
Topics: Animals; Antineoplastic Agents; Aptamers, Nucleotide; Cell Line, Tumor; Cell Membrane Permeability; | 2015 |
Doxorubicin-loaded star-shaped copolymer PLGA-vitamin E TPGS nanoparticles for lung cancer therapy.
Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; Cell Line, Tumor; Cell Survival; Delayed-Action Pre | 2015 |
Nanostructured delivery system for Suberoylanilide hydroxamic acid against lung cancer cells.
Topics: Apoptosis; Cell Line, Tumor; Cell Survival; Diffusion; Drug Synergism; Humans; Hydroxamic Acids; Lac | 2015 |
Biodegradable nanoparticles sequentially decorated with Polyethyleneimine and Hyaluronan for the targeted delivery of docetaxel to airway cancer cells.
Topics: Antineoplastic Agents; Biocompatible Materials; Cell Line; Docetaxel; Drug Delivery Systems; Drug St | 2015 |
Disruption of BASIGIN decreases lactic acid export and sensitizes non-small cell lung cancer to biguanides independently of the LKB1 status.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Antineoplastic Agents; Basigin; Biological Transport; | 2015 |
Verification of Accuracy of CyberKnife Tumor-tracking Radiation Therapy Using Patient-specific Lung Phantoms.
Topics: Carcinoma, Non-Small-Cell Lung; Fiducial Markers; Humans; Lactic Acid; Lung; Lung Neoplasms; Medical | 2015 |
Poly(d,l-lactide-co-glycolide)-chitosan composite particles for the treatment of lung cancer.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Chitosan; Drug Carriers; Drug Synergism; Hum | 2015 |
Signaling through the Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Axis Is Responsible for Aerobic Glycolysis mediated by Glucose Transporter in Epidermal Growth Factor Receptor (EGFR)-mutated Lung Adenocarcinoma.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Aerobiosis; Cell Line, Tumor; Cell Proliferation; ErbB Recep | 2015 |
Intracellular lactate-mediated induction of estrogen receptor beta (ERβ) in biphasic malignant pleural mesothelioma cells.
Topics: Animals; Antineoplastic Agents, Hormonal; Basigin; Cell Line, Tumor; Cell Proliferation; Estrogen Re | 2015 |
Targeting docetaxel-PLA nanoparticles simultaneously inhibit tumor growth and liver metastases of small cell lung cancer.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Docetaxel; Drug Carriers; Drug | 2015 |
Preparation, Characterization, and In Vivo Study of 7-Ethyl-14-Aminocamptothecin-Loaded Poly(Ethylene Glycol)2000 -Poly(Lactic Acid)2000 Polymeric Micelles Against H460 Human Nonsmall Cell Lung Carcinoma.
Topics: Animals; Antineoplastic Agents; Camptothecin; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell | 2015 |
Lasting glycolytic stress governs susceptibility to urethane-induced lung carcinogenesis in vivo and in vitro.
Topics: Animals; Carcinogenesis; Carcinogens; Cell Line, Tumor; Deoxyglucose; Disease Models, Animal; Diseas | 2016 |
Improving DNA double-strand repair inhibitor KU55933 therapeutic index in cancer radiotherapy using nanoparticle drug delivery.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; DNA Breaks, Double-Stranded; Drug Carriers; Drug Delivery S | 2015 |
A Micro/Nano Composite for Combination Treatment of Melanoma Lung Metastasis.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Combined Modality Therapy; Docetaxel; Drug Synergi | 2016 |
Nebulizable colloidal nanoparticles co-encapsulating a COX-2 inhibitor and a herbal compound for treatment of lung cancer.
Topics: Animals; Cell Line, Tumor; Colloids; Cyclooxygenase 2 Inhibitors; Herbal Medicine; Humans; Lactic Ac | 2016 |
Cancer Stem Cells in Small Cell Lung Cancer Cell Line H446: Higher Dependency on Oxidative Phosphorylation and Mitochondrial Substrate-Level Phosphorylation than Non-Stem Cancer Cells.
Topics: Adenosine Triphosphate; Animals; Cell Line, Tumor; Cell Proliferation; Energy Metabolism; Extracellu | 2016 |
A novel paclitaxel-loaded poly(d,l-lactide-co-glycolide)-Tween 80 copolymer nanoparticle overcoming multidrug resistance for lung cancer treatment.
Topics: A549 Cells; Animals; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Survival; | 2016 |
Efficacy and pharmacokinetics of a modified acid-labile docetaxel-PRINT(®) nanoparticle formulation against non-small-cell lung cancer brain metastases.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Cell Line, Tum | 2016 |
Nano-encapsulated chlorophyllin significantly delays progression of lung cancer both in in vitro and in vivo models through activation of mitochondrial signaling cascades and drug-DNA interaction.
Topics: Animals; Antineoplastic Agents; Antioxidants; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Chlo | 2016 |
A comparison between PLGA-PEG and NIPAAm-MAA nanocarriers in curcumin delivery for hTERT silencing in lung cancer cell line.
Topics: Acrylamides; Cell Line, Tumor; Curcumin; Drug Carriers; Gene Expression; Humans; Lactic Acid; Lung N | 2016 |
Improving the Intracellular Drug Concentration in Lung Cancer Treatment through the Codelivery of Doxorubicin and miR-519c Mediated by Porous PLGA Microparticle.
Topics: A549 Cells; Apoptosis; Blotting, Western; Caspase 3; Caspase 8; Caspase 9; Cell Cycle; Cell Survival | 2016 |
Sophoridine-loaded PLGA microspheres for lung targeting: preparation, in vitro, and in vivo evaluation.
Topics: Alkaloids; Animals; Chemistry, Pharmaceutical; Delayed-Action Preparations; Drug Carriers; Emulsions | 2016 |
Development and characterisation of disulfiram-loaded PLGA nanoparticles for the treatment of non-small cell lung cancer.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Disulfiram; Humans; Lactic Acid; Lung Neoplasms; M | 2017 |
Hyaluronic acid coated PLGA nanoparticulate docetaxel effectively targets and suppresses orthotopic human lung cancer.
Topics: A549 Cells; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Docetaxel; Drug Carrier | 2017 |
Gpr132 sensing of lactate mediates tumor-macrophage interplay to promote breast cancer metastasis.
Topics: Animals; Breast Neoplasms; Cell Adhesion; Cell Cycle Proteins; Cell Line, Tumor; Cell Movement; Fema | 2017 |
Silibinin-loaded magnetic nanoparticles inhibit hTERT gene expression and proliferation of lung cancer cells.
Topics: A549 Cells; Cell Proliferation; Drug Carriers; Drug Liberation; Gene Expression Regulation, Neoplast | 2017 |
Disulfiram-loaded porous PLGA microparticle for inhibiting the proliferation and migration of non-small-cell lung cancer.
Topics: Administration, Inhalation; Alcohol Deterrents; Blotting, Western; Carcinoma, Non-Small-Cell Lung; C | 2017 |
The Effects of Nanoencapsulated Curcumin-Fe3O4 on Proliferation and hTERT Gene Expression in Lung Cancer Cells.
Topics: Antineoplastic Agents; Cell Proliferation; Cell Survival; Curcumin; Dose-Response Relationship, Drug | 2017 |
Targeted delivery of doxorubicin by nano-loaded mesenchymal stem cells for lung melanoma metastases therapy.
Topics: Animals; Antineoplastic Agents; Cell Death; Cell Survival; Doxorubicin; Drug Delivery Systems; Lacti | 2017 |
Lung-specific delivery of paclitaxel by chitosan-modified PLGA nanoparticles via transient formation of microaggregates.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Survival; Chitosan; Coumarins; La | 2009 |
The influence of chitosan content in cationic chitosan/PLGA nanoparticles on the delivery efficiency of antisense 2'-O-methyl-RNA directed against telomerase in lung cancer cells.
Topics: Base Sequence; Cations; Cell Line, Tumor; Chitosan; Chromatography, Gel; Chromatography, High Pressu | 2009 |
Studies on bioadhesive PLGA nanoparticles: A promising gene delivery system for efficient gene therapy to lung cancer.
Topics: Acrylic Resins; Adhesiveness; Cell Line, Tumor; Cell Survival; DNA; Drug Carriers; Gene Transfer Tec | 2009 |
Sustained delivery of endostatin improves the efficacy of therapy in Lewis lung cancer model.
Topics: Angiogenesis Inhibitors; Animals; Delayed-Action Preparations; Disease Models, Animal; Endostatins; | 2009 |
Enhanced electrostatic interaction between chitosan-modified PLGA nanoparticle and tumor.
Topics: Animals; Cell Line, Tumor; Cell Survival; Chitosan; Coumarins; Drug Carriers; Humans; Hydrogen-Ion C | 2009 |
Translymphatic chemotherapy by intrapleural placement of gelatin sponge containing biodegradable Paclitaxel colloids controls lymphatic metastasis in lung cancer.
Topics: Absorption; Animals; Antineoplastic Agents, Phytogenic; Colloids; Delayed-Action Preparations; Femal | 2009 |
Preparation and properties of inhalable nanocomposite particles for treatment of lung cancer.
Topics: Administration, Inhalation; Aminoquinolines; Animals; Cell Death; Cell Line, Tumor; Epithelial Cells | 2009 |
Altered regulation of metabolic pathways in human lung cancer discerned by (13)C stable isotope-resolved metabolomics (SIRM).
Topics: Aged; Carbon Isotopes; Female; Gas Chromatography-Mass Spectrometry; Gene Expression Profiling; Gluc | 2009 |
Improved cellular uptake of chitosan-modified PLGA nanospheres by A549 cells.
Topics: Adenocarcinoma; Biological Transport, Active; Cell Line, Tumor; Cell Survival; Chemistry, Pharmaceut | 2009 |
Intratumoral delivery of encapsulated IL-12, IL-18 and TNF-alpha in a model of metastatic breast cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; CD4-Positive T-Lymphocytes; CD8- | 2010 |
Cellular uptake mechanisms and intracellular distributions of polysorbate 80-modified poly (D,L-lactide-co-glycolide) nanospheres for gene delivery.
Topics: Adenocarcinoma; Cell Line, Tumor; Clathrin; DNA; Endocytosis; Gene Transfer Techniques; Genetic Vect | 2010 |
Decreased lung carcinoma cell density on select polymer nanometer surface features for lung replacement therapies.
Topics: Biocompatible Materials; Cell Adhesion; Cell Count; Cell Line, Tumor; Cell Survival; Crystallization | 2010 |
Ketones and lactate "fuel" tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism.
Topics: 3-Hydroxybutyric Acid; Animals; Autophagy; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Female | 2010 |
The relationship between energy status and AMP-activated protein kinase in human H460 lung cancer cells.
Topics: Adenosine Triphosphate; AMP-Activated Protein Kinases; Cell Line, Tumor; Culture Media, Serum-Free; | 2010 |
Metabolism of tumors under treatment: mapping of metabolites with quantitative bioluminescence.
Topics: Adenosine Triphosphate; Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Epothilones; Glyc | 2011 |
Metabolic signatures of lung cancer in biofluids: NMR-based metabonomics of blood plasma.
Topics: Adult; Aged; Aged, 80 and over; Blood Glucose; Female; Humans; Lactic Acid; Lipoproteins; Lung Neopl | 2011 |
Tissue slice model of human lung cancer to investigate telomerase inhibition by nanoparticle delivery of antisense 2'-O-methyl-RNA.
Topics: Carcinoma, Non-Small-Cell Lung; Chitosan; Humans; Lactic Acid; Lung Neoplasms; Nanoparticles; Polygl | 2011 |
Preparation and evaluation of PLGA microparticles as carrier for the pulmonary delivery of rhIL-2 : I. Effects of some formulation parameters on microparticle characteristics.
Topics: Antineoplastic Agents; Cell Survival; Drug Carriers; Drug Compounding; Drug Delivery Systems; Humans | 2011 |
Decreased lung carcinoma cell functions on select polymer nanometer surface features.
Topics: Apoptosis; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Cell Shape; Cell Survival; Epithelia | 2012 |
Bioevaluation study of 32P-CP-PLLA particle brachytherapy in a rabbit VX2 lung tumor model.
Topics: Animals; Brachytherapy; Disease Models, Animal; Fluorodeoxyglucose F18; Lactic Acid; Lung Neoplasms; | 2012 |
The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type.
Topics: Animals; Blotting, Western; Cell Line, Tumor; Cell Transformation, Neoplastic; Citric Acid Cycle; DN | 2012 |
Association of C-terminal region of phosphoglycerate mutase with glycolytic complex regulates energy production in cancer cells.
Topics: Active Transport, Cell Nucleus; Adenosine Triphosphate; Animals; Antineoplastic Agents; Carcinoma, N | 2012 |
Doxorubicin-loaded highly porous large PLGA microparticles as a sustained- release inhalation system for the treatment of metastatic lung cancer.
Topics: Administration, Inhalation; Animals; Antibiotics, Antineoplastic; Capsules; Delayed-Action Preparati | 2012 |
Poly (lactide-co-glycolide) encapsulated extract of Phytolacca decandra demonstrates better intervention against induced lung adenocarcinoma in mice and on A549 cells.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Antineoplastic Agents; Arsenites; bcl-2-Associated | 2012 |
PLGA nanoparticles codeliver paclitaxel and Stat3 siRNA to overcome cellular resistance in lung cancer cells.
Topics: Cell Line, Tumor; Drug Resistance, Neoplasm; Humans; Lactic Acid; Lung Neoplasms; Nanoparticles; Pac | 2012 |
[Effect of co-inhibition of MCT1 gene and NHE1 gene on proliferation and growth of human lung adenocarcinoma cells].
Topics: Adenocarcinoma; Animals; Cell Cycle; Cell Division; Disease Models, Animal; DNA, Antisense; Humans; | 2002 |
[Enzymological observations on lung cancer. An evaluation of changes in lactic acid dehydrogenase activity in patients with primary lung cancer].
Topics: Clinical Enzyme Tests; Humans; L-Lactate Dehydrogenase; Lactic Acid; Lung Neoplasms | 1962 |
[ACTIVITY OF LACTIC ACID DEHYDROGENASE (SLDH) AND OF AMINOTRANSFERASES (SGOT AND SGPT) IN THE BLOOD SERUM IN PRIMARY PULMONARY CANCER AND TUBERCULOSIS].
Topics: Alanine Transaminase; Aspartate Aminotransferases; Blood Chemical Analysis; Clinical Enzyme Tests; D | 1963 |
DIAGNOSTIC SIGNIFICANCE OF URINARY LACTIC ACID DEHYDROGENASE.
Topics: Adenocarcinoma; Albuminuria; Carcinoma, Papillary; Carcinoma, Transitional Cell; Clinical Enzyme Tes | 1964 |
PDLLA/Bioglass composites for soft-tissue and hard-tissue engineering: an in vitro cell biology assessment.
Topics: Biocompatible Materials; Cell Adhesion; Cell Division; Cell Line, Tumor; Cell Survival; Ceramics; Gl | 2004 |
A single treatment with microcapsules containing a CXCR4 antagonist suppresses pulmonary metastasis of murine melanoma.
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Line, Tumor; Delayed-Action Preparations; Dose-R | 2004 |
In vitro proton magnetic resonance spectroscopic lactate and choline measurements, 18F-FDG uptake, and prognosis in patients with lung adenocarcinoma.
Topics: Adenocarcinoma; Aged; Choline; Disease-Free Survival; Female; Fluorodeoxyglucose F18; Humans; Japan; | 2004 |
Pyruvate dehydrogenase and pyruvate dehydrogenase kinase expression in non small cell lung cancer and tumor-associated stroma.
Topics: Autopsy; Carcinoma, Non-Small-Cell Lung; Cell Hypoxia; Fibroblasts; Humans; Hypoxia-Inducible Factor | 2005 |
In-vitro 1H-MRS of excised rabbit lung: evaluation of preservation method of the lung using 10% DMSO solution.
Topics: Animals; Choline; Creatine; Dimethyl Sulfoxide; Lactic Acid; Lung; Lung Neoplasms; Magnetic Resonanc | 2005 |
The effect of poly (aspartic acid-co-lactic acid) nanospheres on the lung metastasis of B16BL6 melanoma cells by intravenous administration.
Topics: Animals; Biocompatible Materials; Cell Line, Tumor; Delayed-Action Preparations; Injections, Intrave | 2006 |
Chitosan-coated PLGA nanoparticles for DNA/RNA delivery: effect of the formulation parameters on complexation and transfection of antisense oligonucleotides.
Topics: Cell Line, Tumor; Chitosan; Coated Materials, Biocompatible; Crystallization; DNA; Drug Carriers; Dr | 2007 |
Sustained delivery of IL-1 Ra from biodegradable microspheres reduces the number of murine B16 melanoma lung metastases.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Chemistry, Pharmaceutical; Del | 2007 |
Liposomal or nanoparticle alpha-TEA reduced 66cl-4 murine mammary cancer burden and metastasis.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Apoptosis; Body Weight; Cell Line, Tumor; Fema | 2007 |
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth.
Topics: Alternative Splicing; Animals; Cell Line, Tumor; Cell Proliferation; Fructosediphosphates; Gene Expr | 2008 |
Clofazimine alters the energy metabolism and inhibits the growth rate of a human lung-cancer cell line in vitro and in vivo.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Carcinoma, Non-Small-Cell Lung; Cell Divisio | 1994 |
Cytokine immunotherapy of cancer with controlled release biodegradable microspheres in a human tumor xenograft/SCID mouse model.
Topics: Animals; Carcinoma, Squamous Cell; Delayed-Action Preparations; Drug Delivery Systems; Humans; Inter | 1998 |
Intratumor pharmacokinetics, flow resistance, and metabolism during gemcitabine infusion in ex vivo perfused human small cell lung cancer.
Topics: Animals; Antimetabolites, Antineoplastic; Carcinoma, Small Cell; Deoxycytidine; Female; Gemcitabine; | 1996 |
T4+ cell numbers are correlated with plasma glutamate and cystine levels: association of hyperglutamataemia with immunodeficiency in diseases with different aetiologies.
Topics: CD4-Positive T-Lymphocytes; Cystine; Glutamates; Glutamic Acid; HIV Seropositivity; HIV-1; Humans; I | 1992 |
Treatment of malignant pleural effusions with doxorubicin hydrochloride-containing poly(L-lactic acid) microspheres.
Topics: Aged; Breast Neoplasms; Chest Tubes; Delayed-Action Preparations; Doxorubicin; Drainage; Drug Carrie | 1991 |
[Intracavitary microspheres incorporating cisplatinum in the treatment of malignant effusions--clinical trials].
Topics: Animals; Ascitic Fluid; Cisplatin; Delayed-Action Preparations; Female; Humans; Infusions, Intraveno | 1990 |
[The role of ascorbic acid in the combined preoperative preparation of cancer patients].
Topics: Administration, Oral; Ascorbic Acid; Ascorbic Acid Deficiency; Combined Modality Therapy; Esophageal | 1989 |
Diagnostic significance of pleural fluid lactate concentration in pleural and pulmonary diseases.
Topics: Adolescent; Adult; Aged; Bacterial Infections; Child; Child, Preschool; Diagnosis, Differential; Hum | 1988 |
Effect of lung resection on blood lactate threshold in lung cancer patients.
Topics: Anaerobiosis; Anthropometry; Body Surface Area; Differential Threshold; Humans; Lactates; Lactic Aci | 1988 |
Exercise tolerance test in lung cancer patients: the relationship between exercise capacity and postthoracotomy hospital mortality.
Topics: Aged; Body Surface Area; Exercise Test; Humans; Lactates; Lactic Acid; Lung Neoplasms; Middle Aged; | 1987 |