lactic acid has been researched along with Lung Diseases, Obstructive in 34 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Lung Diseases, Obstructive: Any disorder marked by obstruction of conducting airways of the lung. AIRWAY OBSTRUCTION may be acute, chronic, intermittent, or persistent.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Lactic acidosis induced by exercise increases the stress on the ventilatory system due to CO2 generated by bicarbonate buffering and hydrogen ion stimulation." | 7.69 | Contribution of the respiratory muscles to the lactic acidosis of heavy exercise in COPD. ( Carithers, E; Casaburi, R; Engelen, MP; Rucker, R, 1995) |
| "During an incremental exercise test, three consequences of the onset of anaerobic metabolism can be observed: rise in blood lactate (lactate threshold, LT); fall in standard bicarbonate (lactic acidosis threshold, LAT); nonlinear increase in CO2 output (V-slope gas exchange threshold, GET)." | 7.68 | Comparison of gas exchange, lactate, and lactic acidosis thresholds in patients with chronic obstructive pulmonary disease. ( Appendini, L; Carone, M; Casaburi, R; Donner, CF; Patessio, A; Wasserman, K, 1993) |
| " Further, we sought to determine whether exercise training at a work rate associated with lactic acidosis is more effective in inducing a training effect in patients with COPD than a work rate not associated with lactic acidosis." | 5.07 | Ventilatory and metabolic changes as a result of exercise training in COPD patients. ( Carone, M; Donner, CF; Ioli, F; Patessio, A, 1992) |
| "Premature lactic acidosis during exercise in patients with chronic obstructive pulmonary disease (COPD) may play a role in exercise intolerance." | 3.70 | Metabolic and hemodynamic responses of lower limb during exercise in patients with COPD. ( Bélanger, M; Bernard, S; Desmeules, M; Jobin, J; Killian, KJ; LeBlanc, P; Maltais, F; Sullivan, MJ; Whittom, F, 1998) |
| "64) l x min(-1)] and mean VO2 at lactic acidosis threshold [LAT, 0." | 3.70 | Gas exchange responses to continuous incremental cycle ergometry exercise in primary pulmonary hypertension in humans. ( Brundage, BH; Engelen, MP; Pórszász, J; Riley, MS; Wasserman, K, 2000) |
| " Lactic acidosis induced by exercise increases the stress on the ventilatory system due to CO2 generated by bicarbonate buffering and hydrogen ion stimulation." | 3.69 | Contribution of the respiratory muscles to the lactic acidosis of heavy exercise in COPD. ( Carithers, E; Casaburi, R; Engelen, MP; Rucker, R, 1995) |
| "During an incremental exercise test, three consequences of the onset of anaerobic metabolism can be observed: rise in blood lactate (lactate threshold, LT); fall in standard bicarbonate (lactic acidosis threshold, LAT); nonlinear increase in CO2 output (V-slope gas exchange threshold, GET)." | 3.68 | Comparison of gas exchange, lactate, and lactic acidosis thresholds in patients with chronic obstructive pulmonary disease. ( Appendini, L; Carone, M; Casaburi, R; Donner, CF; Patessio, A; Wasserman, K, 1993) |
| " Reduced ATP and phosphocreatine content, intracellular acidosis related to hypercapnia, increased muscle lactate without alterations of the muscle lactate concentration gradient were observed in the skeletal muscle of the hypercapnic-hypoxemic COPD patients studied, in which group no correlation was found between hypoxia and energy or lactate metabolism parameters." | 3.67 | Skeletal muscle energetics, acid-base equilibrium and lactate metabolism in patients with severe hypercapnia and hypoxemia. ( Coffrini, E; Del Canale, S; Fiaccadori, E; Guariglia, A; Ronda, N; Vitali, P, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (26.47) | 18.7374 |
| 1990's | 17 (50.00) | 18.2507 |
| 2000's | 7 (20.59) | 29.6817 |
| 2010's | 1 (2.94) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vij, N | 1 |
| Servera, E | 2 |
| Gimenez, M | 1 |
| Belman, MJ | 1 |
| King, RR | 1 |
| Kurihara, N | 2 |
| Funjimoto, S | 1 |
| Ohta, K | 1 |
| Terakawa, K | 1 |
| Hirata, K | 1 |
| Hikiishi, F | 1 |
| Shirai, S | 1 |
| Yamamoto, M | 1 |
| Takeda, T | 1 |
| Kawakami, Y | 1 |
| Cooke, NT | 1 |
| Wilson, SH | 1 |
| Freedman, S | 1 |
| Engelen, MP | 3 |
| Casaburi, R | 4 |
| Rucker, R | 1 |
| Carithers, E | 1 |
| Schönhofer, B | 1 |
| Geibel, M | 1 |
| Wenzel, M | 1 |
| Rosenblüh, J | 1 |
| Köhler, D | 1 |
| Patessio, A | 3 |
| Donner, CF | 3 |
| Carone, M | 2 |
| Appendini, L | 1 |
| Wasserman, K | 2 |
| Maltais, F | 2 |
| Simard, AA | 1 |
| Simard, C | 1 |
| Jobin, J | 2 |
| Desgagnés, P | 1 |
| LeBlanc, P | 2 |
| Viña, J | 1 |
| Asensi, M | 1 |
| Sastre, J | 1 |
| Pallardó, FV | 1 |
| Ferrero, JA | 1 |
| García-De-La-Asunción, J | 1 |
| Antón, V | 1 |
| Marín, J | 1 |
| Porszasz, J | 2 |
| Burns, MR | 1 |
| Carithers, ER | 1 |
| Chang, RS | 1 |
| Cooper, CB | 1 |
| Otsuka, T | 1 |
| Fujii, T | 1 |
| Fujimoto, S | 1 |
| Yoshikawa, J | 1 |
| Sullivan, MJ | 1 |
| Bernard, S | 1 |
| Whittom, F | 1 |
| Killian, KJ | 1 |
| Desmeules, M | 1 |
| Bélanger, M | 1 |
| Mador, MJ | 1 |
| Kufel, TJ | 1 |
| Pineda, LA | 1 |
| Sharma, GK | 1 |
| Art, T | 1 |
| Kirschvink, N | 1 |
| Smith, N | 1 |
| Votion, D | 1 |
| Lekeux, P | 1 |
| Palange, P | 1 |
| Forte, S | 1 |
| Onorati, P | 1 |
| Manfredi, F | 1 |
| Serra, P | 1 |
| Carlone, S | 1 |
| Polkey, MI | 1 |
| Hawkins, P | 1 |
| Kyroussis, D | 1 |
| Ellum, SG | 1 |
| Sherwood, R | 1 |
| Moxham, J | 1 |
| Puente-Maestu, L | 1 |
| Sánz, ML | 1 |
| Sánz, P | 1 |
| Ruíz de Oña, JM | 1 |
| Rodríguez-Hermosa, JL | 1 |
| Whipp, BJ | 1 |
| Schols, AM | 1 |
| Does, JD | 1 |
| Gosker, HR | 1 |
| Deutz, NE | 1 |
| Wouters, EF | 1 |
| Riley, MS | 1 |
| Brundage, BH | 1 |
| Huang, WL | 1 |
| King, SL | 1 |
| Wang, KL | 1 |
| Chiang, CD | 1 |
| Goodnight-White, SJ | 1 |
| Miller, CC | 1 |
| Haber, SE | 1 |
| Klein, PD | 1 |
| Fletcher, EC | 1 |
| Ioli, F | 1 |
| Dekhuijzen, PN | 1 |
| Hopman, MT | 1 |
| Binkhorst, RA | 1 |
| Folgering, HT | 1 |
| Jakobsson, EJ | 1 |
| Jorfeldt, L | 2 |
| Jakobsson, P | 1 |
| Brundin, A | 1 |
| Chida, M | 1 |
| Ichioka, M | 1 |
| Makiguchi, K | 1 |
| Miyazato, I | 1 |
| Suda, Y | 1 |
| Yoshida, T | 1 |
| Fiaccadori, E | 1 |
| Del Canale, S | 1 |
| Vitali, P | 1 |
| Coffrini, E | 1 |
| Ronda, N | 1 |
| Guariglia, A | 1 |
| Volovoĭ, VL | 1 |
| Setrakian, SA | 1 |
| Gu, YW | 1 |
| Huang, DJ | 1 |
| Hu, BX | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Impact of Aerobic Physical Training Associated With Noninvasive Ventilation on COPD Patient Functionality - A Controlled Randomized Study[NCT01464736] | 23 participants (Actual) | Interventional | 2006-01-31 | Completed | |||
| Value of Incentive Spirometry in Routine Management of COPD Patients and Its Effect on Diaphragmatic Function[NCT05679609] | 40 participants (Actual) | Interventional | 2021-03-01 | Completed | |||
| Effect of the Combined (Aerobic/Resisted) and Interval Physical Training on Oxygen Uptake and Heart Rate On-kinetics Responses in Patients With Moderate to Very Severe COPD: Double-blind, Randomized, Controlled Trial[NCT01529489] | 40 participants (Actual) | Interventional | 2008-01-31 | Completed | |||
| Cardiovascular Risk and Chronic Obstructive Pulmonary Disease (COPD)[NCT03014609] | 150 participants (Anticipated) | Observational [Patient Registry] | 2017-01-09 | Recruiting | |||
| Regulation of Nitric Oxide Bioavailability in Chronic Obstructive Pulmonary Disease: A Mechanistic Approach[NCT01398943] | 60 participants (Actual) | Interventional | 2010-09-30 | Completed | |||
| Comparing Exercise Capacity in Patients With COPD Using High Flow Nasal Cannula Oxygen vs The Venturi Mask[NCT02858960] | 28 participants (Actual) | Interventional | 2016-04-30 | Completed | |||
| Exercise Capacity Testing in COPD Patients With High Flow Nasal Cannula[NCT02860273] | 28 participants (Actual) | Interventional | 2016-04-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Brachial artery FMD induced by reactive hyperemia will be used to assess vascular endothelial function at baseline and several hours after each experimental intervention. (NCT01398943)
Timeframe: Post FMD was taken approximately 110 min after baseline
| Intervention | percentage of change in FMD (Mean) | |
|---|---|---|
| Placebo | AOC Treatment | |
| All Controls | 6.7 | 6.9 |
| All COPD Patients | 3.1 | 4.7 |
A measure of vascular stiffness at baseline and several hours after each experimental intervention. (NCT01398943)
Timeframe: Post PWV was taken approximately 90 min after baseline
| Intervention | m/sec (Mean) | |
|---|---|---|
| Placebo | AOC Treatment | |
| All Controls | 11 | 10 |
| All COPD Patients | 14 | 11 |
2 reviews available for lactic acid and Lung Diseases, Obstructive
| Article | Year |
|---|---|
[Pathologic physiology of respiratory failure--respiratory chemosensitivity and tissue oxygenation (author's transl)].
Topics: Adolescent; Adult; Carbon Dioxide; Chemoreceptor Cells; Erythrocytes; Female; Humans; Lactates; Lact | 1982 |
Skeletal muscle function in COPD.
Topics: Anabolic Agents; Biomechanical Phenomena; Dyspnea; Exercise Therapy; Humans; Lactic Acid; Lung Disea | 2000 |
5 trials available for lactic acid and Lung Diseases, Obstructive
| Article | Year |
|---|---|
Selection criteria for exercise training in patients with COPD.
Topics: Acid-Base Equilibrium; Anaerobic Threshold; Carbon Dioxide; Exercise Test; Exercise Therapy; Humans; | 1994 |
Exercise causes blood glutathione oxidation in chronic obstructive pulmonary disease: prevention by O2 therapy.
Topics: Carbon Dioxide; Exercise; Glutathione; Humans; Lactic Acid; Lung Diseases, Obstructive; Male; Middle | 1996 |
Inspiratory pressure support prolongs exercise induced lactataemia in severe COPD.
Topics: Acidosis, Respiratory; Aged; Dyspnea; Exercise Therapy; Forced Expiratory Volume; Humans; Hydrogen-I | 2000 |
Effects of two types of training on pulmonary and cardiac responses to moderate exercise in patients with COPD.
Topics: Aged; Carbon Dioxide; Exercise Test; Exercise Therapy; Forced Expiratory Volume; Heart Rate; Humans; | 2000 |
Ventilatory and metabolic changes as a result of exercise training in COPD patients.
Topics: Acidosis, Lactic; Adult; Anaerobic Threshold; Exercise Test; Exercise Therapy; Humans; Lactates; Lac | 1992 |
Ventilatory and metabolic changes as a result of exercise training in COPD patients.
Topics: Acidosis, Lactic; Adult; Anaerobic Threshold; Exercise Test; Exercise Therapy; Humans; Lactates; Lac | 1992 |
Ventilatory and metabolic changes as a result of exercise training in COPD patients.
Topics: Acidosis, Lactic; Adult; Anaerobic Threshold; Exercise Test; Exercise Therapy; Humans; Lactates; Lac | 1992 |
Ventilatory and metabolic changes as a result of exercise training in COPD patients.
Topics: Acidosis, Lactic; Adult; Anaerobic Threshold; Exercise Test; Exercise Therapy; Humans; Lactates; Lac | 1992 |
27 other studies available for lactic acid and Lung Diseases, Obstructive
| Article | Year |
|---|---|
Synthesis and evaluation of airway targeted PLGA nanoparticles for drug delivery in obstructive lung diseases.
Topics: Aminopyridines; Benzodioxoles; Drug Delivery Systems; Epithelial Cells; Humans; Lactic Acid; Lung Di | 2012 |
VO2 max during progressive and constant bicycle exercise in patients with chronic obstructive lung disease.
Topics: Adult; Aged; Bronchitis; Exercise Test; Forced Expiratory Volume; Heart Rate; Humans; Lactates; Lact | 1984 |
Pulmonary profiling in exercise.
Topics: Asthma, Exercise-Induced; Breathing Exercises; Exercise Test; Humans; Lactates; Lactic Acid; Lung; L | 1984 |
[Changes of blood lactic acid contents during exercises in patients with chronic obstructive lung diseases--with special reference to the anaerobic threshold].
Topics: Female; Humans; Lactates; Lactic Acid; Lung Diseases, Obstructive; Male; Middle Aged; Physical Exert | 1983 |
Blood lactate and respiratory muscle fatigue in patients with chronic airways obstruction.
Topics: Aged; Humans; Lactates; Lactic Acid; Lung Diseases, Obstructive; Male; Maximal Voluntary Ventilation | 1983 |
Contribution of the respiratory muscles to the lactic acidosis of heavy exercise in COPD.
Topics: Acidosis, Lactic; Adult; Exercise; Exercise Tolerance; Female; Forced Expiratory Volume; Humans; Lac | 1995 |
[Increase in hypercapnia in exercise--an unloading strategy?].
Topics: Adult; Carbon Dioxide; Exercise Test; Female; Home Care Services; Humans; Hypercapnia; Intermittent | 1995 |
Comparison of gas exchange, lactate, and lactic acidosis thresholds in patients with chronic obstructive pulmonary disease.
Topics: Acidosis, Lactic; Anaerobic Threshold; Bicarbonates; Carbon Dioxide; Exercise Test; Humans; Lactates | 1993 |
Oxidative capacity of the skeletal muscle and lactic acid kinetics during exercise in normal subjects and in patients with COPD.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Aged; Biopsy; Citrate (si)-Synthase; Exercise Test; Female; Hexoki | 1996 |
Physiologic benefits of exercise training in rehabilitation of patients with severe chronic obstructive pulmonary disease.
Topics: Aged; Capnography; Exercise Test; Exercise Therapy; Female; Heart Rate; Humans; Lactic Acid; Lung Di | 1997 |
Physiologic benefits of exercise training in rehabilitation of patients with severe chronic obstructive pulmonary disease.
Topics: Aged; Capnography; Exercise Test; Exercise Therapy; Female; Heart Rate; Humans; Lactic Acid; Lung Di | 1997 |
Physiologic benefits of exercise training in rehabilitation of patients with severe chronic obstructive pulmonary disease.
Topics: Aged; Capnography; Exercise Test; Exercise Therapy; Female; Heart Rate; Humans; Lactic Acid; Lung Di | 1997 |
Physiologic benefits of exercise training in rehabilitation of patients with severe chronic obstructive pulmonary disease.
Topics: Aged; Capnography; Exercise Test; Exercise Therapy; Female; Heart Rate; Humans; Lactic Acid; Lung Di | 1997 |
Physiologic benefits of exercise training in rehabilitation of patients with severe chronic obstructive pulmonary disease.
Topics: Aged; Capnography; Exercise Test; Exercise Therapy; Female; Heart Rate; Humans; Lactic Acid; Lung Di | 1997 |
Physiologic benefits of exercise training in rehabilitation of patients with severe chronic obstructive pulmonary disease.
Topics: Aged; Capnography; Exercise Test; Exercise Therapy; Female; Heart Rate; Humans; Lactic Acid; Lung Di | 1997 |
Physiologic benefits of exercise training in rehabilitation of patients with severe chronic obstructive pulmonary disease.
Topics: Aged; Capnography; Exercise Test; Exercise Therapy; Female; Heart Rate; Humans; Lactic Acid; Lung Di | 1997 |
Physiologic benefits of exercise training in rehabilitation of patients with severe chronic obstructive pulmonary disease.
Topics: Aged; Capnography; Exercise Test; Exercise Therapy; Female; Heart Rate; Humans; Lactic Acid; Lung Di | 1997 |
Physiologic benefits of exercise training in rehabilitation of patients with severe chronic obstructive pulmonary disease.
Topics: Aged; Capnography; Exercise Test; Exercise Therapy; Female; Heart Rate; Humans; Lactic Acid; Lung Di | 1997 |
Effect of exercise training and detraining on gas exchange kinetics in patients with chronic obstructive pulmonary disease.
Topics: Aged; Exercise Test; Exercise Therapy; Humans; Kinetics; Lactic Acid; Lung Diseases, Obstructive; Ma | 1997 |
Peripheral muscle function in COPD.
Topics: Exercise; Exercise Tolerance; Female; Humans; Lactic Acid; Lung Diseases, Obstructive; Male; Middle | 1997 |
Metabolic and hemodynamic responses of lower limb during exercise in patients with COPD.
Topics: Acidosis, Lactic; Aged; Carbon Dioxide; Exercise; Hemodynamics; Humans; Hydrogen-Ion Concentration; | 1998 |
Diaphragmatic fatigue and high-intensity exercise in patients with chronic obstructive pulmonary disease.
Topics: Diaphragm; Exercise; Exercise Test; Exercise Tolerance; Humans; Lactic Acid; Lung Diseases, Obstruct | 2000 |
Cardiorespiratory measurements and indices of oxidative stress in exercising COPD horses.
Topics: Animals; Blood Gas Analysis; Exercise Test; Glutathione; Heart Rate; Horse Diseases; Horses; Lactic | 1999 |
Ventilatory and metabolic adaptations to walking and cycling in patients with COPD.
Topics: Adaptation, Physiological; Aged; Arteries; Bicycling; Gases; Humans; Lactic Acid; Lung Diseases, Obs | 2000 |
Exercise-induced lactate increase in relation to muscle substrates in patients with chronic obstructive pulmonary disease.
Topics: Aged; Exercise Tolerance; Female; Glucose; Glutamic Acid; Glycogen; Humans; Lactic Acid; Leg; Lung D | 2000 |
Gas exchange responses to continuous incremental cycle ergometry exercise in primary pulmonary hypertension in humans.
Topics: Acidosis, Lactic; Adult; Case-Control Studies; Exercise; Exercise Test; Female; Heart Failure; Human | 2000 |
[Blood lactate changes during incremental exercise in chronic obstructive pulmonary disease].
Topics: Aged; Carbon Dioxide; Exercise; Exercise Test; Humans; Lactates; Lactic Acid; Lung Diseases, Obstruc | 1992 |
Lactate kinetics in severe COPD. Implications of an abnormal aminopyrine breath test.
Topics: Aminopyrine; Anaerobic Threshold; Breath Tests; Exercise; Exercise Test; Humans; Lactates; Lactic Ac | 1992 |
Target-flow inspiratory muscle training: breathing patterns and metabolic costs.
Topics: Adult; Blood Gas Analysis; Breathing Exercises; Energy Metabolism; Evaluation Studies as Topic; Fema | 1991 |
Blood fuel metabolites at rest and during exercise in patients with advanced chronic obstructive pulmonary disease with and without chronic respiratory failure.
Topics: 3-Hydroxybutyric Acid; Alanine; Blood Glucose; Carbon Dioxide; Energy Metabolism; Fatty Acids, Nones | 1990 |
Skeletal muscle metabolites and fibre types in patients with advanced chronic obstructive pulmonary disease (COPD), with and without chronic respiratory failure.
Topics: Adenosine Triphosphate; Biopsy; Creatine; Female; Glycogen; Humans; Lactates; Lactic Acid; Lung Dise | 1990 |
Anaerobic threshold in chronic obstructive pulmonary disease.
Topics: Aged; Anaerobiosis; Energy Metabolism; Exercise Test; Humans; Lactates; Lactic Acid; Lung Diseases, | 1987 |
Skeletal muscle energetics, acid-base equilibrium and lactate metabolism in patients with severe hypercapnia and hypoxemia.
Topics: Acid-Base Equilibrium; Acute Disease; Adenosine Triphosphate; Aged; Energy Metabolism; Female; Human | 1987 |
[Concept of the anaerobic threshold and its clinical significance].
Topics: Acidosis; Cardiac Rehabilitation; Cardiovascular Diseases; Diagnosis, Differential; Dyspnea; Exercis | 1986 |
[Blood lactate in chronic obstructive pulmonary disease with chronic cor pulmonale].
Topics: Aged; Female; Humans; Hypoxia; Lactates; Lactic Acid; Lung Diseases, Obstructive; Male; Middle Aged; | 1985 |