lactic acid and Liver Neoplasms studies

Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.

Research Excerpts

Excerpt	Relevance	Reference
" An immunometabolic strategy for treating colorectal cancer liver metastases using the shikonin-loaded, hyaluronic acid-modified mesoporous polydopamine nanoparticles (SHK@HA-MPDA) via glycolysis inhibition, anticancer immunity activation, and EMT reversal."	8.31	Regulating lactate-related immunometabolism and EMT reversal for colorectal cancer liver metastases using shikonin targeted delivery. ( Chen, G; He, Y; Hou, J; Huang, Y; Lin, F; Long, L; Peng, T; Wang, R; Xiong, W; Xu, Q, 2023)
"This study aimed to investigate the effects of Ginsenoside Rh4 (Rh4) on inflammation-related hepatocellular carcinoma (HCC) progression and the underlying mechanism."	8.31	Ginsenoside Rh4 inhibits inflammation-related hepatocellular carcinoma progression by targeting HDAC4/IL-6/STAT3 signaling. ( Jiang, R; Jiang, X; Luo, S; Qiu, Q; Wang, W; Wu, Y; Yuan, Y; Zhang, M; Zhuo, S, 2023)
"Histone lysine lactylation (Kla) plays a vital role in the tumorigenesis of hepatocellular carcinoma (HCC)."	8.31	Integrated analysis of histone lysine lactylation (Kla)-specific genes suggests that NR6A1, OSBP2 and UNC119B are novel therapeutic targets for hepatocellular carcinoma. ( Li, X; Liu, Q; Long, M; Wu, Q; Xie, X, 2023)
"To explore effects of paclitaxel-loaded poly lactic-co-glycolic acid (PLGA) particles on the viability of human hepatocellular carcinoma (HCC) HepG2 cells."	7.81	Effect of paclitaxel-loaded nanoparticles on the viability of human hepatocellular carcinoma HepG2 cells. ( Hou, ZH; Zhang, Q; Zhao, WC; Zheng, W, 2015)
"To develop salinomycin-loaded poly(lactic-co-glycolic acid) nanoparticles conjugated with both CD133 aptamers A15 and EGFR aptamers CL4 (CESN), to target hepatocellular carcinoma (HCC) cells simultaneously expressing EGFR and CD133."	7.81	The promotion of salinomycin delivery to hepatocellular carcinoma cells through EGFR and CD133 aptamers conjugation by PLGA nanoparticles. ( Chen, H; Chen, M; Jiang, J; Sun, C; Tian, S; Yu, C; Zhang, Y, 2015)
"Transcatheter arterial chemoembolization therapy using polylactic acid microspheres containing aclarubicin hydrochloride (ACR) was performed in 62 patients with primary hepatocellular carcinoma."	7.67	Transcatheter arterial chemoembolization therapy for hepatocellular carcinoma using polylactic acid microspheres containing aclarubicin hydrochloride. ( Akagi, M; Ichihara, T; Mori, K; Sakamoto, K, 1989)
"Targeted hepatocellular carcinoma (HCC) therapy was carried out to improve the efficacy of liver cancers."	5.43	Targeted hepatocellular carcinoma therapy: transferrin modified, self-assembled polymeric nanomedicine for co-delivery of cisplatin and doxorubicin. ( Li, J; Yan, M; Zhang, X, 2016)
"Fialuridine (FIAU) is a nucleoside analog with potent activity against hepatitis B virus in vitro and in vivo."	5.29	Effect of fialuridine on replication of mitochondrial DNA in CEM cells and in human hepatoblastoma cells in culture. ( Colacino, JM; Jaskunas, SR; Malcolm, SK, 1994)
"This study aimed to investigate the effects of Ginsenoside Rh4 (Rh4) on inflammation-related hepatocellular carcinoma (HCC) progression and the underlying mechanism."	4.31	Ginsenoside Rh4 inhibits inflammation-related hepatocellular carcinoma progression by targeting HDAC4/IL-6/STAT3 signaling. ( Jiang, R; Jiang, X; Luo, S; Qiu, Q; Wang, W; Wu, Y; Yuan, Y; Zhang, M; Zhuo, S, 2023)
" An immunometabolic strategy for treating colorectal cancer liver metastases using the shikonin-loaded, hyaluronic acid-modified mesoporous polydopamine nanoparticles (SHK@HA-MPDA) via glycolysis inhibition, anticancer immunity activation, and EMT reversal."	4.31	Regulating lactate-related immunometabolism and EMT reversal for colorectal cancer liver metastases using shikonin targeted delivery. ( Chen, G; He, Y; Hou, J; Huang, Y; Lin, F; Long, L; Peng, T; Wang, R; Xiong, W; Xu, Q, 2023)
"Histone lysine lactylation (Kla) plays a vital role in the tumorigenesis of hepatocellular carcinoma (HCC)."	4.31	Integrated analysis of histone lysine lactylation (Kla)-specific genes suggests that NR6A1, OSBP2 and UNC119B are novel therapeutic targets for hepatocellular carcinoma. ( Li, X; Liu, Q; Long, M; Wu, Q; Xie, X, 2023)
" Correlation of findings with duration of hepatic pedicle clamping, postoperative markers of hepatocellular necrosis and function (aminotransferases, arterial lactate, international normalized ratio, bilirubin), and morbidity."	3.83	Mitochondrial bioenergetics and posthepatectomy liver dysfunction. ( Alexandrino, H; Castro E Sousa, F; Martins, MA; Palmeira, CM; Rolo, AP; Teodoro, JS; Tralhão, JG; Varela, AT, 2016)
"Stepwise pH-responsive nanoparticle system containing charge reversible pullulan-based (CAPL) shell and poly(β-amino ester) (PBAE)/poly(lactic-co-glycolic acid) (PLAG) core is designed to be used as carriers of paclitaxel (PTX) and combretastatin A4 (CA4) for combining antiangiogenesis and chemotherapy to treat hepatocellular carcinoma (HCC)."	3.83	Stepwise pH-responsive nanoparticles containing charge-reversible pullulan-based shells and poly(β-amino ester)/poly(lactic-co-glycolic acid) cores as carriers of anticancer drugs for combination therapy on hepatocellular carcinoma. ( An, T; Li, R; Wan, G; Wang, D; Wang, H; Wang, Y; Yang, X; Zhang, C; Zhang, M; Zhang, S, 2016)
"To develop salinomycin-loaded poly(lactic-co-glycolic acid) nanoparticles conjugated with both CD133 aptamers A15 and EGFR aptamers CL4 (CESN), to target hepatocellular carcinoma (HCC) cells simultaneously expressing EGFR and CD133."	3.81	The promotion of salinomycin delivery to hepatocellular carcinoma cells through EGFR and CD133 aptamers conjugation by PLGA nanoparticles. ( Chen, H; Chen, M; Jiang, J; Sun, C; Tian, S; Yu, C; Zhang, Y, 2015)
"To explore effects of paclitaxel-loaded poly lactic-co-glycolic acid (PLGA) particles on the viability of human hepatocellular carcinoma (HCC) HepG2 cells."	3.81	Effect of paclitaxel-loaded nanoparticles on the viability of human hepatocellular carcinoma HepG2 cells. ( Hou, ZH; Zhang, Q; Zhao, WC; Zheng, W, 2015)
"Sorafenib, a multikinase inhibitor, has been used as an anti-angiogenic agent against highly vascular hepatocellular carcinoma (HCC) - yet associated with only moderate therapeutic effect and the high incidence of HCC recurrence."	3.81	CXCR4-targeted lipid-coated PLGA nanoparticles deliver sorafenib and overcome acquired drug resistance in liver cancer. ( Chang, CC; Chen, Y; Chiang, WH; Gao, DY; Lin, TsT; Liu, JY; Liu, YC; Sung, YC, 2015)
"In present work, lactobionic acid conjugated PLGA nanoparticles (LDNPs) bearing 5-Fluorouracil (5-FU) were developed for targeted delivery to hepatocellular carcinoma."	3.80	Targeting liver cancer via ASGP receptor using 5-FU-loaded surface-modified PLGA nanoparticles. ( Dangi, R; Gulbake, A; Hurkat, P; Jain, A; Jain, SK; Shilpi, S, 2014)
"3-BrPA (3-bromopyruvate) is an alkylating agent with anti-tumoral activity on hepatocellular carcinoma."	3.75	Inhibition of energy-producing pathways of HepG2 cells by 3-bromopyruvate. ( Almeida, FC; Da Poian, AT; da-Silva, WS; dos Santos, RS; El-Bacha, T; Galina, A; Kyaw, N; Pereira da Silva, AP, 2009)
" However, we experienced a patient with liver cirrhosis (LC, Child-Pugh class B) in whom severe lactic acidosis developed during RFA conducted for the treatment of a HCC (-4."	3.71	[Changes in acid-base balance and blood lactate levels during radio frequency ablation conducted for the treatment of hepatocellular carcinomata in patients with liver cirrhosis]. ( Akata, T; Kandabashi, T; Kanna, T; Shiokawa, H; Takahashi, S; Yoshino, J, 2002)
"Transcatheter arterial chemoembolization therapy using polylactic acid microspheres containing aclarubicin hydrochloride (ACR) was performed in 62 patients with primary hepatocellular carcinoma."	3.67	Transcatheter arterial chemoembolization therapy for hepatocellular carcinoma using polylactic acid microspheres containing aclarubicin hydrochloride. ( Akagi, M; Ichihara, T; Mori, K; Sakamoto, K, 1989)
"Of the 20 patients, 17 patients had carcinoid tumors and three had islet cell tumors."	2.69	Two-phase study of hepatic artery vascular occlusion with microencapsulated cisplatin in patients with liver metastases from neuroendocrine tumors. ( Ajani, JA; Brown, CA; Carrasco, HC; Chuang, VP; Diamandidou, E; Lawrence, DD; Wallace, S; Yang, DJ, 1998)
"Osthole can increase the radiosensitivity of hepatoma cells, and its radiosensitization mechanisms may be related to glycolytic inhibition by attenuating the GSK-3β/AMPK/mTOR pathway."	1.91	Osthole increases the radiosensitivity of hepatoma cells by inhibiting GSK-3β/AMPK/mTOR pathway-controlled glycolysis. ( Huang, H; Xie, ML; Xie, T; Xue, J, 2023)
"Human hepatocellular carcinoma (HCC) features include enhanced glycolysis and elevated lactate concentrations."	1.91	Royal jelly acid suppresses hepatocellular carcinoma tumorigenicity by inhibiting H3 histone lactylation at H3K9la and H3K14la sites. ( Li, L; Qu, L; Wang, C; Wang, S; Wang, Z; Xu, H; Xu, K, 2023)
"Currently, conventional treatments of hepatocellular carcinoma (HCC) are not selective enough for tumor tissue and lead to multidrug resistance and drug toxicity."	1.91	Sorafenib-Loaded PLGA Carriers for Enhanced Drug Delivery and Cellular Uptake in Liver Cancer Cells. ( Aliberti, A; Buonaguro, L; Caputo, TM; Carriero, MV; Celetti, G; Cicatiello, P; Cusano, A; Cusano, AM; Micco, A; Minopoli, M; Principe, S; Ragone, C; Ruvo, M; Tagliamonte, M, 2023)
"Lactic acid has been proved to be an important metabolite involved in cancer development, metastasis, and the tumor microenvironment, affecting the prognosis of patients."	1.91	Characteristics of lactate metabolism phenotype in hepatocellular carcinoma. ( Dong, K; Li, C; Wang, W; Yu, J; Zhang, J; Zhang, X, 2023)
"Individuals with hepatocellular carcinoma who responded to anti-PD-1 treatment have lower levels of MOESIN lactylation in Treg cells than nonresponding individuals."	1.72	Tumor metabolite lactate promotes tumorigenesis by modulating MOESIN lactylation and enhancing TGF-β signaling in regulatory T cells. ( Chen, Q; Gao, J; Gu, J; Li, X; Liang, Y; Lu, L; Shao, Q; Wang, Q; Wei, S; Xu, X; Zhou, B; Zhou, H; Zhou, J, 2022)
"Forced miR-342-3p expression in hepatoma cells showed significantly decreased cell proliferation, migration, and colony formation."	1.62	MicroRNA-342-3p is a potent tumour suppressor in hepatocellular carcinoma. ( Balakrishnan, A; Daon, J; Goga, A; Hu, Q; Komoll, RM; Manns, MP; Olarewaju, O; Ott, M; Qin, R; Sharma, AD; Tsay, HC; von Döhlen, L; Xie, Y; Yuan, Q, 2021)
"Curcumin has been demonstrated to affect the chemoresistance in cancer cells of various origins."	1.56	Curcumin circumvent lactate-induced chemoresistance in hepatic cancer cells through modulation of hydroxycarboxylic acid receptor-1. ( Kumar, A; Shukla, D; Soni, VK; Vishvakarma, NK, 2020)
"Among these, hepatocellular carcinoma required lactate dehydrogenase (LDH) for growth more than the 29 other cancer types in this database."	1.56	Functional Genetic Screening Enables Theranostic Molecular Imaging in Cancer. ( Ackerman, D; Gade, TPF; Johnson, O; Mercadante, M; Perkons, NR; Pilla, G; Profka, E, 2020)
"With high morbidity and death rates, liver cancer has become one of the most common cancers in the world."	1.51	Multifunctional nanoplatform based on star-shaped copolymer for liver cancer targeting therapy. ( Chen, K; Chen, Z; Gong, X; He, G; Zeng, X; Zheng, Y, 2019)
"Twenty-nine patients with chronic hepatitis B (CHB), 28 with compensated LC, 33 with decompensated LC, 24 with spontaneous bacterial peritonitis (SBP), 26 with acute-on-chronic liver failure (ACLF), and 24 with decompensated LC complicated by hepatocellular carcinoma (HCC) were recruited."	1.51	Plasma claudin-3 is associated with tumor necrosis factor-alpha-induced intestinal endotoxemia in liver disease. ( Biviano, I; Gong, Z; Hu, J; Liu, H; Wang, A; Wang, Z, 2019)
"HepaRG is a proliferative human hepatoma-derived cell line that can be differentiated into hepatocyte-like and biliary-like cells."	1.51	Comparison of HepaRG cells following growth in proliferative and differentiated culture conditions reveals distinct bioenergetic profiles. ( Young, CKJ; Young, MJ, 2019)
"Colorectal cancer is the third most common malignancy worldwide, with 1."	1.51	Lactate-Mediated Acidification of Tumor Microenvironment Induces Apoptosis of Liver-Resident NK Cells in Colorectal Liver Metastasis. ( Almuaili, D; Geoghegan, J; Hand, F; Harmon, C; Hoti, E; Houlihan, DD; Lynch, L; Mentor, K; O'Farrelly, C; Robinson, MW, 2019)
"Liver cancer is one of the major diseases affecting human health."	1.46	Promising galactose-decorated biodegradable poloxamer 188-PLGA diblock copolymer nanoparticles of resibufogenin for enhancing liver cancer therapy. ( Dong, H; Gao, M; Lv, L; Ma, X; Tian, L; Tian, Y; Wang, C; Xu, H; Zhang, C; Zhang, J, 2017)
"Emodin (EMO) has multi-targets and multi-way antitumor effect, which was limited by the instability and poor solubility of EMO."	1.43	A Promising Emodin-Loaded Poly (Lactic-Co-Glycolic Acid)-d-α-Tocopheryl Polyethylene Glycol 1000 Succinate Nanoparticles for Liver Cancer Therapy. ( Deng, S; Gao, M; Guan, X; Liu, H; Lv, L; Tian, Y; Xu, H; Zhang, C, 2016)
" The liver-targeting RPTN, which displayed enhanced pharmacological effects and decreased toxicity for the loaded drug RBG, is therefore a promising intravenous dosage form that may be useful in the treatment of liver cancer."	1.43	Liver-targeting Resibufogenin-loaded poly(lactic-co-glycolic acid)-D-α-tocopheryl polyethylene glycol 1000 succinate nanoparticles for liver cancer therapy. ( Chu, Q; Deng, S; Gao, M; Guan, X; Huo, X; Liu, H; Liu, K; Ma, X; Tian, Y; Xu, H, 2016)
"Targeted hepatocellular carcinoma (HCC) therapy was carried out to improve the efficacy of liver cancers."	1.43	Targeted hepatocellular carcinoma therapy: transferrin modified, self-assembled polymeric nanomedicine for co-delivery of cisplatin and doxorubicin. ( Li, J; Yan, M; Zhang, X, 2016)
"Hepatocellular carcinomas are frequently nonresponsive to systemically delivered drugs."	1.43	Ultrasound-guided intratumoral delivery of doxorubicin from in situ forming implants in a hepatocellular carcinoma model. ( Exner, AA; Gangolli, M; Hernandez, C; Solorio, L; Wu, H, 2016)
" In conclusion, QPTN could be used as a potential intravenous dosage form for the treatment of liver cancer owing to the enhanced pharmacological effects of QT with increased liver targeting."	1.43	Quercetin-loaded poly (lactic-co-glycolic acid)-d-α-tocopheryl polyethylene glycol 1000 succinate nanoparticles for the targeted treatment of liver cancer. ( Deng, S; Gao, D; Gao, M; Guan, X; Liu, H; Lv, L; Tian, Y; Xu, H; Zhang, C, 2016)
"Treatment options for patients with hepatocellular carcinoma (HCC) are limited, in particular in advanced and drug resistant HCC."	1.43	Ultrasound-guided therapeutic modulation of hepatocellular carcinoma using complementary microRNAs. ( Abou Elkacem, L; Bachawal, S; Choe, JW; Devulapally, R; Mullick Chowdhury, S; Paulmurugan, R; Tian, L; Wang, DS; Wang, TY; Willmann, JK; Yakub, BK, 2016)
"Heparin sodium (HS)-loaded polylactic-co-glycolic acid-D-α-tocopheryl polyethylene glycol 1000 succinate (PLGA-TPGS) nanoparticles (HPTNs) were prepared as sustained and targeted delivery carriers and combined with oleanolic acid (OA)-loaded PLGA-TPGS nanoparticles (OPTNs) that had been investigated in our previous work to form a combination therapy system for the treatment of liver cancer."	1.43	Oleanolic acid-loaded PLGA-TPGS nanoparticles combined with heparin sodium-loaded PLGA-TPGS nanoparticles for enhancing chemotherapy to liver cancer. ( Bao, X; Deng, S; Gao, D; Gao, M; Guan, X; Liu, H; Lv, L; Tian, Y; Wang, C; Xu, H; Zhang, C, 2016)
"Lung cancer is the major cause of cancer related lethality worldwide, and metastasis to distant organs is the pivotal cause of death for the vast majority of lung cancer patients."	1.42	Active targeting docetaxel-PLA nanoparticles eradicate circulating lung cancer stem-like cells and inhibit liver metastasis. ( Hou, C; Jiang, Y; Liu, Y; Sun, B; Yang, N; Zhang, H; Zheng, J; Zuo, P, 2015)
"Oleanolic acid (OA) is a natural triterpenoid, has many important biological actions, including antitumor effect, but its poor solubility often leads to poor pharmacodynamics."	1.42	A novel oleanolic acid-loaded PLGA-TPGS nanoparticle for liver cancer treatment. ( Bao, X; Chu, QC; Gao, M; Guan, X; Jiang, N; Liu, KX; Tian, Y; Xu, H; Zhang, CH, 2015)
" To improve the anti-cancer effect and bioavailability of TAN, we developed a mixed micelle system constituted with D-α-tocopheryl polyethylene glycol succinate-graft-poly(D,L-lactide-co-glycolide) (TPGS-g-PLGA) copolymer and Pluronic F68."	1.40	TPGS-g-PLGA/Pluronic F68 mixed micelles for tanshinone IIA delivery in cancer therapy. ( Chen, M; Fang, X; Li, Y; Wang, Y; Zhang, J; Zhou, D, 2014)
"Ursolic acid (UA) is a naturally bioactive product that exhibits potential anticancer effects."	1.40	Synergism of ursolic acid derivative US597 with 2-deoxy-D-glucose to preferentially induce tumor cell death by dual-targeting of apoptosis and glycolysis. ( Chen, J; Dai, Y; Jia, L; Jiang, Z; Li, Y; Lin, L; Lu, Y; Ou, M; Shao, J; Wang, J; Xiang, L; Yang, X, 2014)
"Glycogen storage disease type I is associated with menorrhagia."	1.39	Menorrhagia in patients with type I glycogen storage disease. ( Austin, SL; El-Gharbawy, AH; James, A; Kasturi, VG; Kishnani, PS, 2013)
"In our experiments, liver cancer cell lines exhibited a range of sensitivity to PKM2 knockdown-mediated growth inhibition."	1.39	Metabolic signature genes associated with susceptibility to pyruvate kinase, muscle type 2 gene ablation in cancer cells. ( Jang, YJ; Jung, Y; Kang, MH; Lee, DC; Oh, SJ; Park, KC; Park, YS; Xie, Z; Yeom, YI; Yoo, HS, 2013)
"First, we found that all the SNU human hepatoma cells with increased glycolytic lactate production have the defective mitochondrial respiratory activity and the Cln-1-mediated high invasive activity."	1.37	Decreased lactate dehydrogenase B expression enhances claudin 1-mediated hepatoma cell invasiveness via mitochondrial defects. ( Kim, BW; Kim, EL; Kim, JH; Lee, SJ; Lee, YK; Park, CB; Wang, HJ; Yoon, CH; Yoon, G, 2011)
"We used highly proliferative human hepatoma Hep G2 cells to assess the growth-related limitation of such direct oxygen supply."	1.36	Spontaneous formation of highly functional three-dimensional multilayer from human hepatoma Hep G2 cells cultured on an oxygen-permeable polydimethylsiloxane membrane. ( Evenou, F; Fujii, T; Sakai, Y, 2010)
" At the dosage of 500 microg/mL, the viability of hepatoma Hep3B cells was approximately 2."	1.36	Antihepatocarcinoma activity of lactic acid bacteria fermented Panax notoginseng. ( Chiang, BH; Lin, YW; Mou, YC; Su, CC, 2010)
"Hepatocellular carcinoma is one of the most common cancers in the world."	1.35	Glucocorticoid protects hepatoma cells against metabolic stress-induced cell death. ( Chi, CW; Ko, PH; Liu, TY; Lui, WY; Uen, YH; Yin, PH, 2008)
"The Wistar rat implantation hepatocellular carcinoma model was set up by inserting the W256 tumor solid piece into Wistar rat's liver."	1.35	[Experimental investigation of hepatic arterial embolism treatment with microsphere encapsulation of adenovirus with HSV-TK gene]. ( Li, XX; Liu, ZM; Yan, LN, 2009)
"The growth of transplantable syngeneic hepatoma 22a was associated with the absence of correlation between nitrite synthesis by peritoneal macrophages and serum lactate concentration."	1.33	Effect of lactate on functional activity of macrophages under normal conditions and during tumor growth. ( Kiseleva, EP; Ogurtsov, RP; Puzyreva, VP, 2006)
"For the potential of targeting liver cancer cells, galactosamine was further conjugated on the prepared nanoparticles as a targeting moiety."	1.33	Preparation of nanoparticles composed of poly(gamma-glutamic acid)-poly(lactide) block copolymers and evaluation of their uptake by HepG2 cells. ( Chen, MC; Huang, CT; Liang, HF; Sung, HW; Yang, TF, 2005)
"Fialuridine (FIAU) is a nucleoside analog with potent activity against hepatitis B virus in vitro and in vivo."	1.29	Effect of fialuridine on replication of mitochondrial DNA in CEM cells and in human hepatoblastoma cells in culture. ( Colacino, JM; Jaskunas, SR; Malcolm, SK, 1994)
"In contrast to the hepatoma cells, rat and human hepatocytes exhibited higher rates of anaerobic glycolysis in the presence of fructose and thus were able to maintain their viability under these conditions."	1.28	Differences in glycolytic capacity and hypoxia tolerance between hepatoma cells and hepatocytes. ( Anundi, I; de Groot, H; Hugo-Wissemann, D; Lauchart, W; Viebahn, R, 1991)

Timeframe	Studies, this research(%)	All Research%
pre-1990	3 (1.84)	18.7374
1990's	9 (5.52)	18.2507
2000's	30 (18.40)	29.6817
2010's	89 (54.60)	24.3611
2020's	32 (19.63)	2.80

Trial	Phase	Enrollment	Study Type	Start Date	Status
Radioactive Holmium Microspheres for the Treatment of Patients With Non-resectable Liver Metastases of Mixed Origin; a Single Center, Interventional, Non-randomized, Open Label, Safety Study.[NCT01031784]	Phase 1	15 participants (Actual)	Interventional	2009-12-31	Completed
A Humanitarian Device Exemption Use Protocol of Therasphere® for Treatment of Unresectable Hepatocellular and Metastatic Liver Tumors - HDE #980006[NCT00701168]		0 participants	Expanded Access		No longer available
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
In vivo dosimetry based on SPECT and MR imaging of 166Ho-microspheres for treatment of liver malignancies. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2013, Volume: 54, Issue:12 Topics: Adult; Aged; Aged, 80 and over; Embolization, Therapeutic; Female; Holmium; Humans; Lactic Acid; Liv	2013
Safety and efficacy of early postoperative hyperbaric oxygen therapy with restriction of transfusions in patients with HCC who have undergone partial hepatectomy. Langenbeck's archives of surgery, 2011, Volume: 396, Issue:1 Topics: Aged; Blood Loss, Surgical; Carcinoma, Hepatocellular; Disease-Free Survival; Erythrocyte Transfusio	2011
Two-phase study of hepatic artery vascular occlusion with microencapsulated cisplatin in patients with liver metastases from neuroendocrine tumors. AJR. American journal of roentgenology, 1998, Volume: 170, Issue:2 Topics: Adenoma, Islet Cell; Antineoplastic Agents; Capsules; Carcinoid Tumor; Chemoembolization, Therapeuti	1998
Anesthesiological management during isolated liver perfusion. Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1998, Volume: 147 Topics: Adult; Aged; Anesthetics; Blood Gas Analysis; Blood Glucose; Chemotherapy, Cancer, Regional Perfusio	1998
The serum interleukin 8 level reflects hepatic mitochondrial redox state in hyperthermochemohypoxic isolated liver perfusion with use of a venovenous bypass. Surgery, 1999, Volume: 125, Issue:3 Topics: Aged; Antineoplastic Agents; Chemotherapy, Cancer, Regional Perfusion; Combined Modality Therapy; Fe	1999

Article	Year
Biodegradable poly(lactide-co-glycolide) microspheres encapsulating hydrophobic contrast agents for transarterial chemoembolization. Journal of biomaterials science. Polymer edition, 2022, Volume: 33, Issue:4 Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Contrast	2022
Monocarboxylate transporter 4 inhibition potentiates hepatocellular carcinoma immunotherapy through enhancing T cell infiltration and immune attack. Hepatology (Baltimore, Md.), 2023, 01-01, Volume: 77, Issue:1 Topics: Animals; Carcinoma, Hepatocellular; Humans; Immunotherapy; Lactic Acid; Liver Neoplasms; Mice; Monoc	2023
Sorafenib-Loaded PLGA-TPGS Nanosystems Enhance Hepatocellular Carcinoma Therapy Through Reversing P-Glycoprotein-Mediated Multidrug Resistance. AAPS PharmSciTech, 2022, Apr-29, Volume: 23, Issue:5 Topics: alpha-Tocopherol; Animals; ATP Binding Cassette Transporter, Subfamily B; Carcinoma, Hepatocellular;	2022
Demethylzeylasteral targets lactate by inhibiting histone lactylation to suppress the tumorigenicity of liver cancer stem cells. Pharmacological research, 2022, Volume: 181 Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cell Trans	2022
Nano co-delivery of Plumbagin and Dihydrotanshinone I reverses immunosuppressive TME of liver cancer. Journal of controlled release : official journal of the Controlled Release Society, 2022, Volume: 348 Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Furans; Lactic Acid; Li	2022
Differential response of hepatocellular carcinoma glycolytic metabolism and oxidative stress markers after exposure to human amniotic membrane proteins. Molecular biology reports, 2022, Volume: 49, Issue:8 Topics: Amnion; Biomarkers; Carcinoma, Hepatocellular; Cell Line, Tumor; Glucose; Glycolysis; Humans; Lactic	2022
Tumor metabolite lactate promotes tumorigenesis by modulating MOESIN lactylation and enhancing TGF-β signaling in regulatory T cells. Cell reports, 2022, 06-21, Volume: 39, Issue:12 Topics: Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Lactic Acid; Liver Neoplasms; M	2022
Inhibition of LPAR6 overcomes sorafenib resistance by switching glycolysis into oxidative phosphorylation in hepatocellular carcinoma. Biochimie, 2022, Volume: 202 Topics: Carcinoma, Hepatocellular; Glycolysis; Humans; Lactic Acid; Liver Neoplasms; Oxidative Phosphorylati	2022
Circ_0031242 regulates the functional properties of hepatocellular carcinoma cells through the miR-944/MAD2L1 axis. Histology and histopathology, 2023, Volume: 38, Issue:3 Topics: Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Humans; Lactic	2023
PFKFB3-mediated Pro-glycolytic Shift in Hepatocellular Carcinoma Proliferation. Cellular and molecular gastroenterology and hepatology, 2023, Volume: 15, Issue:1 Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Glycolysis; Lactic Acid; Liver Neoplasms; Ph	2023
Osthole increases the radiosensitivity of hepatoma cells by inhibiting GSK-3β/AMPK/mTOR pathway-controlled glycolysis. Naunyn-Schmiedeberg's archives of pharmacology, 2023, Volume: 396, Issue:4 Topics: AMP-Activated Protein Kinases; Carcinoma, Hepatocellular; Cell Line, Tumor; Coumarins; Glycogen Synt	2023
Osthole increases the radiosensitivity of hepatoma cells by inhibiting GSK-3β/AMPK/mTOR pathway-controlled glycolysis. Naunyn-Schmiedeberg's archives of pharmacology, 2023, Volume: 396, Issue:4 Topics: AMP-Activated Protein Kinases; Carcinoma, Hepatocellular; Cell Line, Tumor; Coumarins; Glycogen Synt	2023
Osthole increases the radiosensitivity of hepatoma cells by inhibiting GSK-3β/AMPK/mTOR pathway-controlled glycolysis. Naunyn-Schmiedeberg's archives of pharmacology, 2023, Volume: 396, Issue:4 Topics: AMP-Activated Protein Kinases; Carcinoma, Hepatocellular; Cell Line, Tumor; Coumarins; Glycogen Synt	2023
Osthole increases the radiosensitivity of hepatoma cells by inhibiting GSK-3β/AMPK/mTOR pathway-controlled glycolysis. Naunyn-Schmiedeberg's archives of pharmacology, 2023, Volume: 396, Issue:4 Topics: AMP-Activated Protein Kinases; Carcinoma, Hepatocellular; Cell Line, Tumor; Coumarins; Glycogen Synt	2023
Silencing RPL8 inhibits the progression of hepatocellular carcinoma by down-regulating the mTORC1 signalling pathway. Human cell, 2023, Volume: 36, Issue:2 Topics: Carcinoma, Hepatocellular; Humans; Lactic Acid; Liver Neoplasms; Mechanistic Target of Rapamycin Com	2023
Monodisperse CaCO International journal of biological macromolecules, 2023, Mar-15, Volume: 231 Topics: Animals; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Doxorubicin; Drug Carriers; Gela	2023
Regulating lactate-related immunometabolism and EMT reversal for colorectal cancer liver metastases using shikonin targeted delivery. Journal of experimental & clinical cancer research : CR, 2023, May-10, Volume: 42, Issue:1 Topics: Animals; CD8-Positive T-Lymphocytes; Colorectal Neoplasms; Epithelial-Mesenchymal Transition; Humans	2023
Poly lactic-co-glycolic acid-alginate nanocarrier for efficient drug delivery to liver cancer cells. IET nanobiotechnology, 2023, Volume: 17, Issue:5 Topics: Alginates; Doxorubicin; Drug Carriers; Drug Delivery Systems; Drug Liberation; Glycols; Humans; Lact	2023
Royal jelly acid suppresses hepatocellular carcinoma tumorigenicity by inhibiting H3 histone lactylation at H3K9la and H3K14la sites. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2023, Volume: 118 Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Histones; Humans; Lactic Acid; Liver Neoplasms	2023
d-lactate modulates M2 tumor-associated macrophages and remodels immunosuppressive tumor microenvironment for hepatocellular carcinoma. Science advances, 2023, 07-21, Volume: 9, Issue:29 Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Immunosuppressive Agents; Lactic Acid; Liver N	2023
Sorafenib-Loaded PLGA Carriers for Enhanced Drug Delivery and Cellular Uptake in Liver Cancer Cells. International journal of nanomedicine, 2023, Volume: 18 Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Carriers; Humans; Lactic Acid; Liver Neoplasms; Na	2023
Ginsenoside Rh4 inhibits inflammation-related hepatocellular carcinoma progression by targeting HDAC4/IL-6/STAT3 signaling. Molecular genetics and genomics : MGG, 2023, Volume: 298, Issue:6 Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferation; Glucose; Hi	2023
Integrated analysis of histone lysine lactylation (Kla)-specific genes suggests that NR6A1, OSBP2 and UNC119B are novel therapeutic targets for hepatocellular carcinoma. Scientific reports, 2023, 10-30, Volume: 13, Issue:1 Topics: Carcinoma, Hepatocellular; Histones; Humans; Lactic Acid; Liver Neoplasms; Lysine; Nuclear Receptor	2023
Characteristics of lactate metabolism phenotype in hepatocellular carcinoma. Scientific reports, 2023, 11-11, Volume: 13, Issue:1 Topics: Carcinoma, Hepatocellular; Cluster Analysis; Humans; Lactic Acid; Liver Neoplasms; Phenotype; Progno	2023
Inhibition of GSK-3β activity suppresses HCC malignant phenotype by inhibiting glycolysis via activating AMPK/mTOR signaling. Cancer letters, 2019, Oct-28, Volume: 463 Topics: Adenosine Triphosphate; AMP-Activated Protein Kinases; Antibodies, Monoclonal, Humanized; Carcinoma,	2019
Metformin Induces Oxidative Stress-Mediated Apoptosis without the Blockade of Glycolysis in H4IIE Hepatocellular Carcinoma Cells. Biological & pharmaceutical bulletin, 2019, Volume: 42, Issue:12 Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Glucos	2019
Curcumin circumvent lactate-induced chemoresistance in hepatic cancer cells through modulation of hydroxycarboxylic acid receptor-1. The international journal of biochemistry & cell biology, 2020, Volume: 123 Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Survival; Chromatin; Cisplatin; Curcumin; Doxorubici	2020
[Effect of ultrasound contrast agent targeting gelatin on uptake of mouse ascites hepatocellular carcinoma cell lines with high lymphatic metastasis]. Zhonghua zhong liu za zhi [Chinese journal of oncology], 2020, Apr-23, Volume: 42, Issue:4 Topics: Animals; Ascites; Carcinoma, Hepatocellular; Cell Line; Contrast Media; Diagnostic Imaging; Gelatin;	2020
Functional Genetic Screening Enables Theranostic Molecular Imaging in Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research, 2020, 09-01, Volume: 26, Issue:17 Topics: Animals; Carbon-13 Magnetic Resonance Spectroscopy; Carcinoma, Hepatocellular; CRISPR-Cas Systems; D	2020
MicroRNA-342-3p is a potent tumour suppressor in hepatocellular carcinoma. Journal of hepatology, 2021, Volume: 74, Issue:1 Topics: Animals; Biological Transport; Carcinoma, Hepatocellular; Cell Movement; Cell Proliferation; Disease	2021
QSOX1 promotes mitochondrial apoptosis of hepatocellular carcinoma cells during anchorage-independent growth by inhibiting lipid synthesis. Biochemical and biophysical research communications, 2020, 11-05, Volume: 532, Issue:2 Topics: Anoikis; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cholesterol; En	2020
HCAR1/MCT1 Regulates Tumor Ferroptosis through the Lactate-Mediated AMPK-SCD1 Activity and Its Therapeutic Implications. Cell reports, 2020, 12-08, Volume: 33, Issue:10 Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Coen	2020
Serum lactate level predicts 6-months mortality in patients with hepatitis B virus-related decompensated cirrhosis: a retrospective study. Epidemiology and infection, 2021, 01-05, Volume: 149 Topics: Aged; Ascites; Carcinoma, Hepatocellular; Female; gamma-Glutamyltransferase; Hepatitis B; Hepatitis	2021
Fat Induces Glucose Metabolism in Nontransformed Liver Cells and Promotes Liver Tumorigenesis. Cancer research, 2021, 04-15, Volume: 81, Issue:8 Topics: Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Citric Acid Cycle; Diet, High-F	2021
Bioactivity Profiles of Cytoprotective Short-Chain Quinones. Molecules (Basel, Switzerland), 2021, Mar-04, Volume: 26, Issue:5 Topics: 3-Hydroxybutyric Acid; Adenosine Triphosphate; Apoptosis; Carcinoma, Hepatocellular; Cell Proliferat	2021
Loss-of-Function Genetic Screening Identifies Aldolase A as an Essential Driver for Liver Cancer Cell Growth Under Hypoxia. Hepatology (Baltimore, Md.), 2021, Volume: 74, Issue:3 Topics: Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Animals; Carcinoma, Hepatocellular; Cell Line, Tumor;	2021
PLGA-based dual targeted nanoparticles enhance miRNA transfection efficiency in hepatic carcinoma. Scientific reports, 2017, 04-07, Volume: 7 Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Disease Models, Animal; Dynamic Light Scatteri	2017
Imaging-guided synergetic therapy of orthotopic transplantation tumor by superselectively arterial administration of microwave-induced microcapsules. Biomaterials, 2017, Volume: 133 Topics: Animals; Capsules; Carcinoma, Hepatocellular; Doxorubicin; Lactates; Lactic Acid; Liver Neoplasms; M	2017
PLGA-PEG-RA-based polymeric micelles for tumor targeted delivery of irinotecan. Pharmaceutical development and technology, 2018, Volume: 23, Issue:1 Topics: Camptothecin; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Carriers; Drug Delivery Systems; Hep	2018
Orexin A affects HepG2 human hepatocellular carcinoma cells glucose metabolism via HIF-1α-dependent and -independent mechanism. PloS one, 2017, Volume: 12, Issue:9 Topics: Adenosine Triphosphate; Carcinoma, Hepatocellular; Citric Acid Cycle; Gene Expression; Gene Expressi	2017
Promising galactose-decorated biodegradable poloxamer 188-PLGA diblock copolymer nanoparticles of resibufogenin for enhancing liver cancer therapy. Drug delivery, 2017, Volume: 24, Issue:1 Topics: Animals; Bufanolides; Galactose; Humans; Lactic Acid; Liver Neoplasms; Mice; Nanoparticles; Poloxame	2017
Fabrication, optimization, and characterization of umbelliferone β-D-galactopyranoside-loaded PLGA nanoparticles in treatment of hepatocellular carcinoma: in vitro and in vivo studies. International journal of nanomedicine, 2017, Volume: 12 Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor;	2017
High-Performance Poly(lactic-co-glycolic acid)-Magnetic Microspheres Prepared by Rotating Membrane Emulsification for Transcatheter Arterial Embolization and Magnetic Ablation in VX ACS applied materials & interfaces, 2017, Dec-20, Volume: 9, Issue:50 Topics: Animals; Carcinoma, Hepatocellular; Glycols; Lactic Acid; Liver Neoplasms; Magnetics; Microspheres;	2017
Response to: Post-hepatectomy Lactate: Should We Add More? And Assessing Predictive Value of Post-operative Elevated Lactate for Adverse Outcomes Following Hepatectomy. World journal of surgery, 2018, Volume: 42, Issue:5 Topics: Hepatectomy; Humans; Lactic Acid; Liver Neoplasms; Postoperative Period	2018
Poly(lactic- International journal of nanomedicine, 2018, Volume: 13 Topics: Administration, Oral; Animals; Antineoplastic Agents; Apoptosis; Betulinic Acid; Carcinoma, Hepatoce	2018
miR-221 suppression through nanoparticle-based miRNA delivery system for hepatocellular carcinoma therapy and its diagnosis as a potential biomarker. International journal of nanomedicine, 2018, Volume: 13 Topics: Aged; Animals; Biomarkers, Tumor; Carcinoma, Hepatocellular; Case-Control Studies; Cell Line, Tumor;	2018
Lactate-Mediated Acidification of Tumor Microenvironment Induces Apoptosis of Liver-Resident NK Cells in Colorectal Liver Metastasis. Cancer immunology research, 2019, Volume: 7, Issue:2 Topics: Adult; Aged; Apoptosis; Biological Transport; Biomarkers; Biopsy; Cell Line, Tumor; Colorectal Neopl	2019
Comparison of HepaRG cells following growth in proliferative and differentiated culture conditions reveals distinct bioenergetic profiles. Cell cycle (Georgetown, Tex.), 2019, Volume: 18, Issue:4 Topics: Acetaminophen; Adenosine Triphosphate; Carcinoma, Hepatocellular; Cell Culture Techniques; Cell Diff	2019
Plasma claudin-3 is associated with tumor necrosis factor-alpha-induced intestinal endotoxemia in liver disease. Clinics and research in hepatology and gastroenterology, 2019, Volume: 43, Issue:4 Topics: Acute-On-Chronic Liver Failure; Adult; Aged; Analysis of Variance; Biomarkers; Carcinoma, Hepatocell	2019
Blood and urine analyses after radioembolization of liver malignancies with [ Nuclear medicine and biology, 2019, Volume: 71 Topics: Drug Stability; Embolization, Therapeutic; Humans; Hydroxybutyrates; Lactates; Lactic Acid; Liver Ne	2019
Multifunctional nanoplatform based on star-shaped copolymer for liver cancer targeting therapy. Drug delivery, 2019, Volume: 26, Issue:1 Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cholic Acid; Drug Delivery Systems; Drug Liberatio	2019
Quantitative measurement of cancer metabolism using stimulated echo hyperpolarized carbon-13 MRS. Magnetic resonance in medicine, 2014, Volume: 71, Issue:1 Topics: Alanine; Algorithms; Animals; Biomarkers, Tumor; Carbon Isotopes; Computer Simulation; Lactic Acid;	2014
Ultrasound exposure improves the targeted therapy effects of galactosylated docetaxel nanoparticles on hepatocellular carcinoma xenografts. PloS one, 2013, Volume: 8, Issue:3 Topics: Animals; Antineoplastic Agents; Biomarkers; Carcinoma, Hepatocellular; Docetaxel; Drug Carriers; Fem	2013
Metabolic signature genes associated with susceptibility to pyruvate kinase, muscle type 2 gene ablation in cancer cells. Molecules and cells, 2013, Volume: 35, Issue:4 Topics: Carcinoma, Hepatocellular; Carrier Proteins; Cell Line, Tumor; Cell Survival; Gene Expression; Gene	2013
Two p53-related metabolic regulators, TIGAR and SCO2, contribute to oroxylin A-mediated glucose metabolism in human hepatoma HepG2 cells. The international journal of biochemistry & cell biology, 2013, Volume: 45, Issue:7 Topics: Apoptosis; Apoptosis Regulatory Proteins; Biological Transport; Carcinoma, Hepatocellular; Carrier P	2013
Bio-responsive chitin-poly(L-lactic acid) composite nanogels for liver cancer. Colloids and surfaces. B, Biointerfaces, 2014, Jan-01, Volume: 113 Topics: Cell Survival; Chitin; Doxorubicin; Hemolysis; Hep G2 Cells; Humans; Lactic Acid; Liver Neoplasms; N	2014
Menorrhagia in patients with type I glycogen storage disease. Obstetrics and gynecology, 2013, Volume: 122, Issue:6 Topics: Adenoma; Adult; Anemia; Blood Glucose; Female; Glycogen Storage Disease Type I; Hemoglobins; Hormone	2013
In-vitro anticancer and antimicrobial activities of PLGA/silver nanofiber composites prepared by electrospinning. Journal of materials science. Materials in medicine, 2014, Volume: 25, Issue:4 Topics: Anti-Infective Agents; Antineoplastic Agents; Biocompatible Materials; Cell Line; Drug Delivery Syst	2014
SM5-1-conjugated PLA nanoparticles loaded with 5-fluorouracil for targeted hepatocellular carcinoma imaging and therapy. Biomaterials, 2014, Volume: 35, Issue:9 Topics: Animals; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellu	2014
miR-122 targets pyruvate kinase M2 and affects metabolism of hepatocellular carcinoma. PloS one, 2014, Volume: 9, Issue:1 Topics: Apoptosis; Biomarkers, Tumor; Blotting, Western; Carcinoma, Hepatocellular; Carrier Proteins; Cell P	2014
The aspartate metabolism pathway is differentiable in human hepatocellular carcinoma: transcriptomics and (13) C-isotope based metabolomics. NMR in biomedicine, 2014, Volume: 27, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Alanine; Aspartic Acid; Carbon Isotopes; Carcinoma, Hepatocellular;	2014
Targeting liver cancer via ASGP receptor using 5-FU-loaded surface-modified PLGA nanoparticles. Journal of microencapsulation, 2014, Volume: 31, Issue:5 Topics: Antimetabolites, Antineoplastic; Carcinoma, Hepatocellular; Drug Delivery Systems; Fluorouracil; Hep	2014
[Effect of PLGA nanoparticles conjugated with anti-OX40/anti-AFP mAbs on cytotoxicity of CTL cells against hepatocellular carcinoma]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2014, Volume: 30, Issue:4 Topics: alpha-Fetoproteins; Antibodies, Monoclonal; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Prolif	2014
Improved antitumor activity and reduced cardiotoxicity of epirubicin using hepatocyte-targeted nanoparticles combined with tocotrienols against hepatocellular carcinoma in mice. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2014, Volume: 88, Issue:1 Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; C	2014
A novel oleanolic acid-loaded PLGA-TPGS nanoparticle for liver cancer treatment. Drug development and industrial pharmacy, 2015, Volume: 41, Issue:7 Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Coumarins; Delayed-Action Preparations; Drug Carri	2015
TPGS-g-PLGA/Pluronic F68 mixed micelles for tanshinone IIA delivery in cancer therapy. International journal of pharmaceutics, 2014, Dec-10, Volume: 476, Issue:1-2 Topics: Abietanes; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Biological Availability; Carcinoma	2014
Low-intensity focused ultrasound mediated localized drug delivery for liver tumors in rabbits. Drug delivery, 2016, Volume: 23, Issue:7 Topics: Animals; Apoptosis; Doxorubicin; Drug Delivery Systems; Lactic Acid; Liver; Liver Neoplasms; Liver N	2016
Active targeting docetaxel-PLA nanoparticles eradicate circulating lung cancer stem-like cells and inhibit liver metastasis. Molecular pharmaceutics, 2015, Jan-05, Volume: 12, Issue:1 Topics: AC133 Antigen; Animals; Antigens, CD; Antineoplastic Agents; Body Weight; Cell Line, Tumor; Docetaxe	2015
Composition-property relationships for radiopaque composite materials: pre-loaded drug-eluting beads for transarterial chemoembolization. Journal of biomaterials applications, 2015, Volume: 30, Issue:1 Topics: Antibiotics, Antineoplastic; Carcinoma, Hepatocellular; Cell Survival; Chemoembolization, Therapeuti	2015
The unreliability of continuous postoperative lactate monitoring after extended hepatectomies: single center experience. Updates in surgery, 2015, Volume: 67, Issue:1 Topics: Adult; Aged; Female; Follow-Up Studies; Hepatectomy; Hospital Records; Humans; Incidence; Italy; Lac	2015
Effect of paclitaxel-loaded nanoparticles on the viability of human hepatocellular carcinoma HepG2 cells. Asian Pacific journal of cancer prevention : APJCP, 2015, Volume: 16, Issue:5 Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Prol	2015
Synergism of ursolic acid derivative US597 with 2-deoxy-D-glucose to preferentially induce tumor cell death by dual-targeting of apoptosis and glycolysis. Scientific reports, 2014, May-21, Volume: 4 Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocell	2014
PLGA-Loaded Gold-Nanoparticles Precipitated with Quercetin Downregulate HDAC-Akt Activities Controlling Proliferation and Activate p53-ROS Crosstalk to Induce Apoptosis in Hepatocarcinoma Cells. Molecules and cells, 2015, Volume: 38, Issue:6 Topics: Apoptosis; Cell Proliferation; Down-Regulation; Gold; HeLa Cells; Hep G2 Cells; Histone Deacetylase	2015
MiR-199a-5p is negatively associated with malignancies and regulates glycolysis and lactate production by targeting hexokinase 2 in liver cancer. Hepatology (Baltimore, Md.), 2015, Volume: 62, Issue:4 Topics: Female; Glycolysis; Hexokinase; Humans; Lactic Acid; Liver Neoplasms; Male; MicroRNAs; Middle Aged;	2015
The promotion of salinomycin delivery to hepatocellular carcinoma cells through EGFR and CD133 aptamers conjugation by PLGA nanoparticles. Nanomedicine (London, England), 2015, Volume: 10, Issue:12 Topics: AC133 Antigen; Antigens, CD; Antineoplastic Agents; Aptamers, Nucleotide; Carcinoma, Hepatocellular;	2015
Glycyrrhetinic Acid-Mediated Polymeric Drug Delivery Targeting the Acidic Microenvironment of Hepatocellular Carcinoma. Pharmaceutical research, 2015, Volume: 32, Issue:10 Topics: Acids; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Carriers; D	2015
CXCR4-targeted lipid-coated PLGA nanoparticles deliver sorafenib and overcome acquired drug resistance in liver cancer. Biomaterials, 2015, Volume: 67 Topics: Animals; Carcinoma, Hepatocellular; Cell Death; Cell Line, Tumor; Cell Proliferation; Drug Delivery	2015
Oroxylin A regulates glucose metabolism in response to hypoxic stress with the involvement of Hypoxia-inducible factor-1 in human hepatoma HepG2 cells. Molecular carcinogenesis, 2016, Volume: 55, Issue:8 Topics: Carcinoma, Hepatocellular; Cell Hypoxia; Energy Metabolism; Flavonoids; Gene Expression Regulation,	2016
Targeting docetaxel-PLA nanoparticles simultaneously inhibit tumor growth and liver metastases of small cell lung cancer. International journal of pharmaceutics, 2015, Oct-15, Volume: 494, Issue:1 Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Docetaxel; Drug Carriers; Drug	2015
A Promising Emodin-Loaded Poly (Lactic-Co-Glycolic Acid)-d-α-Tocopheryl Polyethylene Glycol 1000 Succinate Nanoparticles for Liver Cancer Therapy. Pharmaceutical research, 2016, Volume: 33, Issue:1 Topics: alpha-Tocopherol; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Delayed-Action Prepar	2016
Glycyrrhetinic acid-decorated and reduction-sensitive micelles to enhance the bioavailability and anti-hepatocellular carcinoma efficacy of tanshinone IIA. Biomaterials science, 2016, Volume: 4, Issue:1 Topics: Abietanes; Animals; Biological Availability; Carcinoma, Hepatocellular; Cell Line, Tumor; Delayed-Ac	2016
Active glycolytic metabolism in CD133(+) hepatocellular cancer stem cells: regulation by MIR-122. Oncotarget, 2015, Dec-01, Volume: 6, Issue:38 Topics: AC133 Antigen; Adenosine Triphosphate; Antigens, CD; Blotting, Western; Carcinoma, Hepatocellular; C	2015
Study of levan productivity from Bacillus subtilis Natto by surface response methodology and its antitumor activity against HepG2 cells using metabolomic approach. Pakistan journal of pharmaceutical sciences, 2015, Volume: 28, Issue:6 Topics: Acetic Acid; Alanine; Antineoplastic Agents; Bacillus subtilis; Energy Metabolism; Fermentation; Fru	2015
Genistein-loaded nanoparticles of star-shaped diblock copolymer mannitol-core PLGA-TPGS for the treatment of liver cancer. Materials science & engineering. C, Materials for biological applications, 2016, Volume: 59 Topics: Animals; Drug Carriers; Genistein; Hep G2 Cells; Humans; Lactic Acid; Liver Neoplasms; Mannitol; Mic	2016
Silver nanoparticles affect glucose metabolism in hepatoma cells through production of reactive oxygen species. International journal of nanomedicine, 2016, Volume: 11 Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Glucose; Hep G2 C	2016
Improved antitumor activity of epirubicin-loaded CXCR4-targeted polymeric nanoparticles in liver cancers. International journal of pharmaceutics, 2016, Mar-16, Volume: 500, Issue:1-2 Topics: Animals; Antibiotics, Antineoplastic; Cell Survival; Drug Liberation; Epirubicin; Hep G2 Cells; Huma	2016
Microtubule targeted therapeutics loaded polymeric assembled nanospheres for potentiation of antineoplastic activity. Faraday discussions, 2016, Volume: 186 Topics: Antineoplastic Agents; Cell Death; Cell Line, Tumor; Cell Proliferation; Drug Carriers; Drug Deliver	2016
Nanoparticle-enhanced synergistic HIFU ablation and transarterial chemoembolization for efficient cancer therapy. Nanoscale, 2016, Feb-21, Volume: 8, Issue:7 Topics: Angiography; Animals; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Contrast Media; Dru	2016
Liver-targeting Resibufogenin-loaded poly(lactic-co-glycolic acid)-D-α-tocopheryl polyethylene glycol 1000 succinate nanoparticles for liver cancer therapy. International journal of nanomedicine, 2016, Volume: 11 Topics: Animals; Antineoplastic Agents; Apoptosis; Bufanolides; Coumarins; Drug Carriers; Hep G2 Cells; Huma	2016
Stepwise pH-responsive nanoparticles containing charge-reversible pullulan-based shells and poly(β-amino ester)/poly(lactic-co-glycolic acid) cores as carriers of anticancer drugs for combination therapy on hepatocellular carcinoma. Journal of controlled release : official journal of the Controlled Release Society, 2016, Mar-28, Volume: 226 Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Proliferation; Delayed-Action Prepar	2016
Targeted hepatocellular carcinoma therapy: transferrin modified, self-assembled polymeric nanomedicine for co-delivery of cisplatin and doxorubicin. Drug development and industrial pharmacy, 2016, Volume: 42, Issue:10 Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Cisplatin; Doxorubicin;	2016
Ultrasound-guided intratumoral delivery of doxorubicin from in situ forming implants in a hepatocellular carcinoma model. Therapeutic delivery, 2016, Volume: 7, Issue:4 Topics: Administration, Intravenous; Animals; Antibiotics, Antineoplastic; Carcinoma, Hepatocellular; Cell L	2016
Quercetin-loaded poly (lactic-co-glycolic acid)-d-α-tocopheryl polyethylene glycol 1000 succinate nanoparticles for the targeted treatment of liver cancer. Drug delivery, 2016, Volume: 23, Issue:9 Topics: Animals; Antineoplastic Agents; Apoptosis; Drug Carriers; Drug Delivery Systems; Hep G2 Cells; Human	2016
Mitochondrial bioenergetics and posthepatectomy liver dysfunction. European journal of clinical investigation, 2016, Volume: 46, Issue:7 Topics: Adenoma; Adenosine Triphosphate; Adult; Aged; Aged, 80 and over; Alanine Transaminase; Aspartate Ami	2016
Dual-drug loaded nanoformulation with a galactosamine homing moiety for liver-targeted anticancer therapy. Dalton transactions (Cambridge, England : 2003), 2016, Aug-16, Volume: 45, Issue:33 Topics: alpha-Tocopherol; Antineoplastic Agents; Caspase 3; Cell Line, Tumor; Cell Survival; Drug Carriers;	2016
Impairment of oxidative phosphorylation increases the toxicity of SYD-1 on hepatocarcinoma cells (HepG2). Chemico-biological interactions, 2016, Aug-25, Volume: 256 Topics: Adenosine Triphosphate; Antineoplastic Agents; Carcinoma, Hepatocellular; Hep G2 Cells; Hepatocytes;	2016
Significance of glycolytic metabolism-related protein expression in colorectal cancer, lymph node and hepatic metastasis. BMC cancer, 2016, 07-26, Volume: 16 Topics: Basigin; Biomarkers, Tumor; Colorectal Neoplasms; Glucose Transporter Type 1; Glycolysis; Humans; Im	2016
Ultrasound-guided therapeutic modulation of hepatocellular carcinoma using complementary microRNAs. Journal of controlled release : official journal of the Controlled Release Society, 2016, 09-28, Volume: 238 Topics: Animals; Antagomirs; Antibiotics, Antineoplastic; Carcinoma, Hepatocellular; Doxorubicin; Drug Deliv	2016
Poly lactic-co-glycolic acid controlled delivery of disulfiram to target liver cancer stem-like cells. Nanomedicine : nanotechnology, biology, and medicine, 2017, Volume: 13, Issue:2 Topics: Acetaldehyde Dehydrogenase Inhibitors; Animals; Disulfiram; Drug Carriers; Glycols; Humans; Lactic A	2017
Oleanolic acid-loaded PLGA-TPGS nanoparticles combined with heparin sodium-loaded PLGA-TPGS nanoparticles for enhancing chemotherapy to liver cancer. Life sciences, 2016, Nov-15, Volume: 165 Topics: Animals; Antineoplastic Agents; Hep G2 Cells; Heparin; Humans; Lactic Acid; Liver Neoplasms; Mice; N	2016
A Redox-Sensitive and RAGE-Targeting Nanocarrier for Hepatocellular Carcinoma Therapy. Molecular pharmaceutics, 2016, 11-07, Volume: 13, Issue:11 Topics: Apoptosis; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Diterpenes	2016
Multifunctional SPIO/DOX-loaded A54 Homing Peptide Functionalized Dextran-g-PLGA Micelles for Tumor Therapy and MR Imaging. Scientific reports, 2016, 10-24, Volume: 6 Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Contrast Media; Disease	2016
Cinnamic Acid Derivatives Enhance the Efficacy of Transarterial Embolization in a Rat Model of Hepatocellular Carcinoma. Cardiovascular and interventional radiology, 2017, Volume: 40, Issue:3 Topics: Acrylates; Animals; Caffeic Acids; Cell Line, Tumor; Coumaric Acids; Disease Models, Animal; Emboliz	2017
Gemcitabine and Antisense-microRNA Co-encapsulated PLGA-PEG Polymer Nanoparticles for Hepatocellular Carcinoma Therapy. ACS applied materials & interfaces, 2016, Dec-14, Volume: 8, Issue:49 Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Deoxycytidine; Drug Carriers; Drug Delivery Systems; Ge	2016
MT1-MMP Responsive Doxorubicin Conjugated Poly(lactic-co-glycolic Acid)/Poly(styrene-alt-maleic Anhydride) Core/Shell Microparticles for Intrahepatic Arterial Chemotherapy of Hepatic Cancer. ACS applied materials & interfaces, 2017, 01-11, Volume: 9, Issue:1 Topics: Animals; Doxorubicin; Glycols; Lactic Acid; Liver Neoplasms; Maleic Anhydrides; Matrix Metalloprotei	2017
[Clinical effect of ultrasound-guided injection of biodegradable poly(lactic-co-glycolic acid)-Fe Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2016, Dec-20, Volume: 24, Issue:12 Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cattle; Ferrosoferric Oxide; Glycolates;	2016
Therapeutic efficacy of novel microwave-sensitized mPEG-PLGA@ZrO Nanoscale, 2017, Mar-09, Volume: 9, Issue:10 Topics: Animals; Doxorubicin; Drug Carriers; Lactic Acid; Liver Neoplasms; Microspheres; Microwaves; Neoplas	2017
[Metabonomic study of blood plasma in the assessment of liver graft function]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 2007, Volume: 29, Issue:6 Topics: Acetone; Alanine; Biomarkers; Blood Glucose; Carcinoma; Choline; Glutamine; Humans; Lactic Acid; Liv	2007
Treatment of hepatocellular carcinoma in mice with PE38KDEL type I mutant-loaded poly(lactic-co-glycolic acid) nanoparticles conjugated with humanized SM5-1 F(ab') fragments. Molecular cancer therapeutics, 2008, Volume: 7, Issue:10 Topics: Animals; Antibodies; Antibodies, Monoclonal; Binding, Competitive; Carcinoma, Hepatocellular; Cell P	2008
Inhibition of energy-producing pathways of HepG2 cells by 3-bromopyruvate. The Biochemical journal, 2009, Feb-01, Volume: 417, Issue:3 Topics: Adenosine Triphosphate; Carcinoma, Hepatocellular; Energy Metabolism; Enzyme Inhibitors; Glyceraldeh	2009
Glucocorticoid protects hepatoma cells against metabolic stress-induced cell death. International journal of oncology, 2008, Volume: 33, Issue:6 Topics: 2-Methoxyestradiol; Animals; Apoptosis; bcl-X Protein; Carcinoma, Hepatocellular; Caspases; Cell Cyc	2008
In vivo targeted gene delivery by cationic nanoparticles for treatment of hepatocellular carcinoma. The journal of gene medicine, 2009, Volume: 11, Issue:1 Topics: alpha-Fetoproteins; Animals; Asialoglycoproteins; Carcinoma, Hepatocellular; Fatty Acids, Monounsatu	2009
Neutron activation of holmium poly(L-lactic acid) microspheres for hepatic arterial radio-embolization: a validation study. Biomedical microdevices, 2009, Volume: 11, Issue:4 Topics: Animals; Calorimetry, Differential Scanning; Embolization, Therapeutic; Hepatic Artery; Holmium; Hum	2009
Glutathione and amino acid concentrations in human liver during short warm ischaemia and reperfusion: a pilot study. Clinical science (London, England : 1979), 2009, Sep-01, Volume: 117, Issue:9 Topics: Adult; Aged; Amino Acids; Female; Glutathione; Hepatectomy; Humans; Intraoperative Care; Lactic Acid	2009
Spontaneous formation of highly functional three-dimensional multilayer from human hepatoma Hep G2 cells cultured on an oxygen-permeable polydimethylsiloxane membrane. Tissue engineering. Part C, Methods, 2010, Volume: 16, Issue:2 Topics: Carcinoma, Hepatocellular; Cell Culture Techniques; Cell Proliferation; Dimethylpolysiloxanes; Dose-	2010
Liver transplantation for glycogen storage disease type Ia. Journal of hepatology, 2009, Volume: 51, Issue:3 Topics: Adult; Blood Glucose; Carcinoma, Hepatocellular; Cholesterol; Follow-Up Studies; Glycogen Storage Di	2009
[Experimental investigation of hepatic arterial embolism treatment with microsphere encapsulation of adenovirus with HSV-TK gene]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2009, Volume: 40, Issue:3 Topics: Adenoviridae; Animals; Carcinoma, Hepatocellular; Embolization, Therapeutic; Genes, Transgenic, Suic	2009
Targeting of tumor endothelium by RGD-grafted PLGA-nanoparticles loaded with paclitaxel. Journal of controlled release : official journal of the Controlled Release Society, 2009, Dec-03, Volume: 140, Issue:2 Topics: Animals; Antineoplastic Agents, Phytogenic; Biological Transport; Cells, Cultured; Chemistry, Pharma	2009
Alginate-encapsulated human hepatoma C3A cells for use in a bioartificial liver device - the hybrid-MDS. The International journal of artificial organs, 2009, Volume: 32, Issue:11 Topics: Albumins; Alginates; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Chromatography	2009
Interleukin 6 enhances glycolysis through expression of the glycolytic enzymes hexokinase 2 and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3. Journal of Nippon Medical School = Nippon Ika Daigaku zasshi, 2010, Volume: 77, Issue:2 Topics: Animals; Fibroblasts; Glucose; Glycolysis; Hep G2 Cells; Hexokinase; Humans; Inflammation Mediators;	2010
Antihepatocarcinoma activity of lactic acid bacteria fermented Panax notoginseng. Journal of agricultural and food chemistry, 2010, Aug-11, Volume: 58, Issue:15 Topics: Animals; Antineoplastic Agents, Phytogenic; Bacteria; Cell Line, Tumor; Disease Models, Animal; Drug	2010
Partial liver ischemia is followed by metabolic changes in the normally perfused part of the liver during reperfusion. European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 2010, Volume: 45, Issue:2 Topics: Animals; Colorectal Neoplasms; Disease Models, Animal; Female; Glucose; Glycerol; Humans; Ischemia;	2010
Development of PLGA nanoparticles simultaneously loaded with vincristine and verapamil for treatment of hepatocellular carcinoma. Journal of pharmaceutical sciences, 2010, Volume: 99, Issue:12 Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Chemistry, Pharmaceutical; Drug	2010
Improved therapeutic effect of DOX-PLGA-PEG micelles decorated with bivalent fragment HAb18 F(ab')(2) for hepatocellular carcinoma. Biomacromolecules, 2010, Sep-13, Volume: 11, Issue:9 Topics: Animals; Antibiotics, Antineoplastic; Antibodies, Monoclonal; Carcinoma, Hepatocellular; Cell Line,	2010
Decreased lactate dehydrogenase B expression enhances claudin 1-mediated hepatoma cell invasiveness via mitochondrial defects. Experimental cell research, 2011, May-01, Volume: 317, Issue:8 Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Respiration; Claudin-1; Glycolysis; Humans; Isoenz	2011
In vivo MRSI of hyperpolarized [1-(13)C]pyruvate metabolism in rat hepatocellular carcinoma. NMR in biomedicine, 2011, Volume: 24, Issue:5 Topics: Alanine; Animals; Carbon Isotopes; Carcinoma, Hepatocellular; Gene Expression Regulation, Neoplastic	2011
cNGR conjugated poly(lactic acid)-poly(ethylene glycol) nanoparticles for targeted gene delivery. Journal of controlled release : official journal of the Controlled Release Society, 2011, Nov-30, Volume: 152 Suppl 1 Topics: Caveolae; CD13 Antigens; DNA; Endocytosis; Flow Cytometry; Hep G2 Cells; Human Umbilical Vein Endoth	2011
Hematoporphyrin encapsulated PLGA microbubble for contrast enhanced ultrasound imaging and sonodynamic therapy. Journal of microencapsulation, 2012, Volume: 29, Issue:5 Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Contrast Media; Equipment Design; Hematoporphy	2012
Magnetic resonance imaging-based radiation-absorbed dose estimation of 166Ho microspheres in liver radioembolization. International journal of radiation oncology, biology, physics, 2012, Jul-01, Volume: 83, Issue:3 Topics: Algorithms; Autoradiography; Embolization, Therapeutic; Holmium; Humans; Lactic Acid; Liver; Liver N	2012
Analysis of urinary metabolic signatures of early hepatocellular carcinoma recurrence after surgical removal using gas chromatography-mass spectrometry. Journal of proteome research, 2012, Aug-03, Volume: 11, Issue:8 Topics: Aconitic Acid; Adult; Aged; Biomarkers, Tumor; Carcinoma, Hepatocellular; Energy Metabolism; Ethanol	2012
Paracrine Hedgehog signaling drives metabolic changes in hepatocellular carcinoma. Cancer research, 2012, Dec-15, Volume: 72, Issue:24 Topics: Animals; Carcinoma, Hepatocellular; Cells, Cultured; Fatty Liver; Glycolysis; Hedgehog Proteins; Hep	2012
Acidic milieu augments the expression of hepcidin, the central regulator of iron homeostasis. International journal of hematology, 2012, Volume: 96, Issue:6 Topics: Acids; Antimicrobial Cationic Peptides; Carbon Dioxide; Carcinoma, Hepatocellular; Cell Line, Tumor;	2012
[Changes in acid-base balance and blood lactate levels during radio frequency ablation conducted for the treatment of hepatocellular carcinomata in patients with liver cirrhosis]. Masui. The Japanese journal of anesthesiology, 2002, Volume: 51, Issue:11 Topics: Acid-Base Equilibrium; Aged; Carcinoma, Hepatocellular; Catheter Ablation; Female; Hepatectomy; Huma	2002
Prevention of heterocyclic amine-induced DNA damage in colon and liver of rats by different lactobacillus strains. Carcinogenesis, 2003, Volume: 24, Issue:12 Topics: Amines; Animals; Colon; Colonic Neoplasms; Comet Assay; DNA; DNA Damage; Lactic Acid; Lactobacillus;	2003
Ischaemic change of the human intestine after total portal occlusion during liver resection. South African journal of surgery. Suid-Afrikaanse tydskrif vir chirurgie, 2001, Volume: 39, Issue:2 Topics: Adult; Aged; Female; Gallstones; Hepatectomy; Humans; Intestines; Lactic Acid; Liver Neoplasms; Male	2001
Preparation and characteristics of DNA-nanoparticles targeting to hepatocarcinoma cells. World journal of gastroenterology, 2004, Mar-01, Volume: 10, Issue:5 Topics: Animals; Biocompatible Materials; Carcinoma, Hepatocellular; Cell Line, Tumor; Deoxyribonuclease I;	2004
[Study on the preparation of TK-gene nanoparticles and its expression]. Yao xue xue bao = Acta pharmaceutica Sinica, 2004, Volume: 39, Issue:4 Topics: alpha-Fetoproteins; Biocompatible Materials; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Deliv	2004
Surface characteristics of holmium-loaded poly(L-lactic acid) microspheres. Biomaterials, 2005, Volume: 26, Issue:8 Topics: Holmium; Lactic Acid; Liver Neoplasms; Microscopy, Electron, Scanning; Microspheres; Polyesters; Pol	2005
Preparation of nanoparticles composed of poly(gamma-glutamic acid)-poly(lactide) block copolymers and evaluation of their uptake by HepG2 cells. Journal of controlled release : official journal of the Controlled Release Society, 2005, Jul-20, Volume: 105, Issue:3 Topics: Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Fluorescent Dyes; Galactosamine; Humans;	2005
Local release of dexamethasone from polymer millirods effectively prevents fibrosis after radiofrequency ablation. Journal of biomedical materials research. Part A, 2006, Volume: 76, Issue:1 Topics: 2-Hydroxypropyl-beta-cyclodextrin; Animals; Anti-Inflammatory Agents; beta-Cyclodextrins; Biocompati	2006
Differentiation effects by the combination of spheroid formation and sodium butyrate treatment in human hepatoblastoma cell line (Hep G2): a possible cell source for hybrid artificial liver. Cell transplantation, 2005, Volume: 14, Issue:10 Topics: Albumins; Ammonia; Animals; Butyrates; Cell Line, Tumor; Cell Proliferation; Enzyme Activation; Fema	2005
[Cytotoxicity of cytotoxic T lymphocytes induced by the dendritic cells phagocytosing PLA-AFP218-226 micospheres Against hepatocellular carcinoma cell lines]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2006, Volume: 37, Issue:3 Topics: alpha-Fetoproteins; Carcinoma, Hepatocellular; Cell Line, Tumor; Dendritic Cells; HLA-A2 Antigen; Hu	2006
Effect of lactate on functional activity of macrophages under normal conditions and during tumor growth. Bulletin of experimental biology and medicine, 2006, Volume: 141, Issue:1 Topics: Animals; Carcinoma, Hepatocellular; Lactic Acid; Liver Neoplasms; Macrophages, Peritoneal; Male; Mic	2006
Antitumor efficacy and local distribution of doxorubicin via intratumoral delivery from polymer millirods. Journal of biomedical materials research. Part A, 2007, Volume: 81, Issue:1 Topics: Absorbable Implants; Animals; Antibiotics, Antineoplastic; Delayed-Action Preparations; Doxorubicin;	2007
Hypoxia-inducible factor-1 confers resistance to the glycolytic inhibitor 2-deoxy-D-glucose. Molecular cancer therapeutics, 2007, Volume: 6, Issue:2 Topics: Adenosine Triphosphate; Antimetabolites; Apoptosis; Carcinoma, Hepatocellular; Cell Hypoxia; Deoxygl	2007
Hepatocellular adenoma and metabolic balance in patients with type Ia glycogen storage disease. Molecular genetics and metabolism, 2008, Volume: 93, Issue:4 Topics: Adenoma, Liver Cell; Adolescent; Adult; Body Mass Index; Case-Control Studies; Child; Child, Prescho	2008
Clinical effects of transcatheter hepatic arterial embolization with holmium-166 poly(L-lactic acid) microspheres in healthy pigs. European journal of nuclear medicine and molecular imaging, 2008, Volume: 35, Issue:7 Topics: Animals; Catheterization; Embolization, Therapeutic; Female; Hepatic Artery; Holmium; Humans; Lactic	2008
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Effect of fialuridine on replication of mitochondrial DNA in CEM cells and in human hepatoblastoma cells in culture. Antimicrobial agents and chemotherapy, 1994, Volume: 38, Issue:9 Topics: Antiviral Agents; Arabinofuranosyluracil; Cells, Cultured; DNA Replication; DNA, Mitochondrial; Hepa	1994
Biotinidase activity in patients with liver disease. Scandinavian journal of gastroenterology, 1993, Volume: 28, Issue:10 Topics: 3-Hydroxybutyric Acid; Acute Disease; Adult; Aged; Amidohydrolases; Biotin; Biotinidase; Carcinoma,	1993
Measurement of lactate levels in serum and bile using proton nuclear magnetic resonance in patients with hepatobiliary diseases: its utility in detection of malignancies. Japanese journal of clinical oncology, 1997, Volume: 27, Issue:1 Topics: Adult; Aged; alpha-Fetoproteins; Bile; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Biomarkers; Bi	1997
Holmium-166 poly lactic acid microspheres applicable for intra-arterial radionuclide therapy of hepatic malignancies: effects of preparation and neutron activation techniques. European journal of nuclear medicine, 1999, Volume: 26, Issue:7 Topics: Brachytherapy; Drug Delivery Systems; Holmium; Humans; Lactic Acid; Liver Neoplasms; Microspheres; N	1999
Differential effects of antiretroviral nucleoside analogs on mitochondrial function in HepG2 cells. Antimicrobial agents and chemotherapy, 2000, Volume: 44, Issue:3 Topics: Anti-HIV Agents; Carcinoma, Hepatocellular; Citrate (si)-Synthase; DNA, Mitochondrial; Electron Tran	2000
Targeting of liver tumour in rats by selective delivery of holmium-166 loaded microspheres: a biodistribution study. European journal of nuclear medicine, 2001, Volume: 28, Issue:6 Topics: Animals; Autoradiography; Excipients; Holmium; Lactic Acid; Liver; Liver Neoplasms; Male; Microspher	2001
Characterization of poly(L-lactic acid) microspheres loaded with holmium acetylacetonate. Biomaterials, 2001, Volume: 22, Issue:22 Topics: Biocompatible Materials; Calorimetry, Differential Scanning; Embolization, Therapeutic; Holmium; Hum	2001
Influence of neutron irradiation on holmium acetylacetonate loaded poly(L-lactic acid) microspheres. Biomaterials, 2002, Volume: 23, Issue:8 Topics: Calorimetry, Differential Scanning; Embolization, Therapeutic; Gamma Rays; Holmium; Humans; Hydroxyb	2002
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Transcatheter arterial chemoembolization therapy for hepatocellular carcinoma using polylactic acid microspheres containing aclarubicin hydrochloride. Cancer research, 1989, Aug-01, Volume: 49, Issue:15 Topics: Aclarubicin; Adult; Aged; alpha-Fetoproteins; Animals; Carcinoma, Hepatocellular; Dogs; Embolization	1989
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lactic acid and Liver Neoplasms

Research Excerpts

Research

Studies (163)

Authors

Clinical Trials (2)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Jeon, SI	1
Kim, MS	1
Kim, HJ	1
Kim, YI	1
Jae, HJ	1
Ahn, CH	1
Fang, Y	1
Liu, W	4
Tang, Z	1
Ji, X	1
Zhou, Y	4
Song, S	1
Tian, M	1
Tao, C	1
Huang, R	1
Zhu, G	1
Jiang, X	3
Gao, J	6
Qu, W	1
Wang, H	4
Zhou, P	1
Wu, X	1
Jin, L	1
Sun, H	1
Ding, Z	1
Peng, Y	1
Zhao, S	1
Zhou, J	2
Fan, J	1
Xu, W	1
Shi, Y	1
Tang, M	1
Huang, Y	2
Liang, X	2
Tao, Y	1
He, N	1
Li, Z	3
Guo, J	3
Gui, S	1
Pan, L	1
Feng, F	1
Wu, J	1
Fan, S	1
Han, J	1
Wang, S	3
Yang, L	5
Wang, C	4
Xu, K	2
Han, S	2
Bi, S	1
Guo, T	1
Sun, D	1
Zou, Y	2
Wang, L	2
Song, L	1
Chu, D	1
Liao, A	2
Song, X	1
Yu, Z	2
Alves, AP	1
Rocha, SM	1
Mamede, AC	1
Braga, PC	1
Alves, MG	1
Oliveira, PF	1
Botelho, FM	1
Maia, CJ	1
Gu, J	2
Chen, Q	1
Xu, X	1
Li, X	2
Shao, Q	1
Zhou, B	2
Zhou, H	2
Wei, S	1
Wang, Q	2
Liang, Y	2
Lu, L	1
Zhang, Y	5
Zhai, Z	1
Duan, J	1
Wang, X	4
Zhong, J	2
Wu, L	2
Li, A	1
Cao, M	1
Wu, Y	2
Shi, H	1
Guo, Z	2
Gnocchi, D	1
Kurzyk, A	1
Mintrone, A	1
Lentini, G	1
Sabbà, C	1
Mazzocca, A	1
Lin, J	1
Lin, Z	3
Hua, Y	1
Chen, Y	4
Dou, Q	1
Grant, AK	1
Callahan, C	1
Coutinho de Souza, P	1
Mwin, D	1
Booth, AL	1
Nasser, I	1
Moussa, M	1
Ahmed, M	1
Tsai, LL	1
Huang, H	3
Xue, J	3
Xie, T	3
Xie, ML	3
Sun, T	1
Zhu, W	1
Ru, Q	1
Zheng, Y	5
Chen, M	6
Guo, X	1
Shen, L	1
Ding, J	2
Yu, J	2
Chen, X	3
Wu, F	1
Tu, J	1
Zhao, Z	1
Nakajima, M	1
Song, J	1
Shu, G	1
Ji, J	2
Long, L	1
Xiong, W	1
Lin, F	1
Hou, J	1
Chen, G	1
Peng, T	1
He, Y	3
Wang, R	1
Xu, Q	1
Hoseinzadeh, M	1
Mokhtari, MJ	1
Kafilzadeh, F	1
Mohammadnejad, J	1
Taheri, Y	1
Xu, H	7
Li, L	2
Wang, Z	8
Qu, L	1
Bao, X	3
Li, Y	3
Zhang, X	5
Liang, D	1
Dai, Y	2
Zheng, QC	1
Caputo, TM	1
Cusano, AM	1
Principe, S	1
Cicatiello, P	1
Celetti, G	1
Aliberti, A	1
Micco, A	1
Ruvo, M	1
Tagliamonte, M	1
Ragone, C	1
Minopoli, M	1
Carriero, MV	1
Buonaguro, L	1
Cusano, A	1
Jiang, R	1
Luo, S	1
Zhang, M	4
Wang, W	3
Zhuo, S	1
Qiu, Q	1
Yuan, Y	1
Wu, Q	1
Long, M	1
Xie, X	1
Liu, Q	1
Zhang, J	8
Dong, K	1
Li, C	1
Fang, G	1
Zhang, P	2
Liu, J	3
Zhu, X	2
Li, R	2
Park, D	1
Soni, VK	1
Shukla, D	1
Kumar, A	1
Vishvakarma, NK	1
Yuan, JJ	1
Zhu, HH	1
Shao, LY	1
Perkons, NR	1
Johnson, O	1
Pilla, G	1
Profka, E	1
Mercadante, M	1
Ackerman, D	1
Gade, TPF	1
Komoll, RM	1
Hu, Q	1
Olarewaju, O	1
von Döhlen, L	1
Yuan, Q	1
Xie, Y	2
Tsay, HC	1
Daon, J	1
Qin, R	1
Manns, MP	1
Sharma, AD	1
Goga, A	2
Ott, M	1
Balakrishnan, A	1
Ma, Q	1
Yu, M	1
Zhao, Y	5
Li, M	2
Yao, X	1
Fei, Y	1
Cai, K	1
Luo, Z	1
Nie, Y	1
Liu, LX	1
Chen, T	2
Broadfield, LA	1
Duarte, JAG	1
Schmieder, R	1
Broekaert, D	1
Veys, K	1
Planque, M	1
Vriens, K	1
Karasawa, Y	1
Napolitano, F	1
Fujita, S	1
Fujii, M	1
Eto, M	1
Holvoet, B	1
Vangoitsenhoven, R	1
Fernandez-Garcia, J	1
Van Elsen, J	1
Dehairs, J	1
Zeng, J	1
Dooley, J	1
Rubio, RA	1
van Pelt, J	1
Grünewald, TGP	1
Liston, A	1
Mathieu, C	1
Deroose, CM	1
Swinnen, JV	1
Lambrechts, D	1
di Bernardo, D	1
Kuroda, S	1
De Bock, K	1
Fendt, SM	1
Feng, Z	1
Nadikudi, M	1
Woolley, KL	1
Hemasa, AL	1
Chear, S	1
Smith, JA	1
Gueven, N	1
Niu, Y	1
Wan, A	1
Sun, L	1
Yan, S	1
Liang, H	1
Zhan, S	1
Chen, D	1
Bu, X	1
Liu, P	2
Chen, C	1
He, W	1
Lu, X	2
Wan, G	2
Cai, C	1
Liu, H	6
Zou, H	1
Liu, D	1
Kong, X	1
Tang, S	2
Fu, C	2
Tan, L	1
Liu, T	1
Mao, J	2
Ren, X	1
Su, H	2
Long, D	2
Chai, Q	1
Huang, Z	1
Wang, J	2
Ren, J	1
Meng, X	2
Emami, J	1
Maghzi, P	1
Hasanzadeh, F	1
Sadeghi, H	1
Mirian, M	1
Rostami, M	1
Wan, X	1
Liu, Y	4
Sun, X	2
Fan, D	1
Guo, L	1
Dong, H	1
Tian, L	2
Gao, M	6
Zhang, C	6
Lv, L	4
Tian, Y	6
Ma, X	3
Kumar, V	1
Bhatt, PC	1
Rahman, M	1
Kaithwas, G	1
Choudhry, H	1
Al-Abbasi, FA	1
Anwar, F	1
Verma, A	1
Liang, YJ	1
Yu, H	1
Feng, G	1
Zhuang, L	1
Xi, W	1
Ma, M	1
Chen, J	3
Gu, N	1
Lemke, M	1
Hallet, J	1
Kumar, P	1
Singh, AK	1
Raj, V	1
Rai, A	1
Keshari, AK	1
Kumar, D	1
Maity, B	1
Prakash, A	1
Maiti, S	1
Saha, S	1
Li, F	1
Wang, F	1
Zhu, C	2
Wei, Q	1
Zhang, T	1
Zhou, YL	1
Harmon, C	1
Robinson, MW	1
Hand, F	1
Almuaili, D	1
Mentor, K	1
Houlihan, DD	1
Hoti, E	1
Lynch, L	1
Geoghegan, J	1
O'Farrelly, C	1
Young, CKJ	1
Young, MJ	1
Wang, A	1
Gong, Z	1
Biviano, I	1
Hu, J	1
Bakker, RC	1
de Roos, R	2
Ververs, FFT	1
Lam, MGEH	1
van der Lee, MK	1
Zonnenberg, BA	4
Krijger, GC	3
Gong, X	1
He, G	2
Chen, K	2
Zeng, X	1
Chen, Z	4
Swisher, CL	1
Larson, PE	1
Kruttwig, K	1
Kerr, AB	1
Hu, S	1
Bok, RA	1
Pauly, JM	1
Nelson, SJ	1
Kurhanewicz, J	1
Vigneron, DB	1
Wei, H	1
Huang, J	1
Yang, J	1
Lin, L	2
Xue, E	1
Jung, Y	1
Jang, YJ	1
Kang, MH	1
Park, YS	1
Oh, SJ	1
Lee, DC	1
Xie, Z	1
Yoo, HS	1
Park, KC	1
Yeom, YI	1
Dai, Q	2
Yin, Y	1
Wei, L	2
You, Q	1
Lu, N	2
Guo, Q	1
Arunraj, TR	1
Sanoj Rejinold, N	1
Ashwin Kumar, N	1
Jayakumar, R	1
Smits, ML	1
Elschot, M	1
van den Bosch, MA	1
van de Maat, GH	2
van het Schip, AD	6
Seevinck, PR	3
Verkooijen, HM	1
Bakker, CJ	2
de Jong, HW	1
Lam, MG	1
Nijsen, JF	8
Austin, SL	2
El-Gharbawy, AH	1
Kasturi, VG	1
James, A	1
Kishnani, PS	2
Almajhdi, FN	1
Fouad, H	1
Khalil, KA	1
Awad, HM	1
Mohamed, SH	1
Elsarnagawy, T	1
Albarrag, AM	1
Al-Jassir, FF	1
Abdo, HS	1
Cheng, Z	1
Jin, Y	1
Yang, X	3
Dai, Z	1
Tian, J	1
Liu, AM	1
Xu, Z	1
Shek, FH	1
Wong, KF	1
Lee, NP	1
Poon, RT	1
Luk, JM	1
Darpolor, MM	2
Basu, SS	1
Worth, A	1
Nelson, DS	1
Clarke-Katzenberg, RH	2
Glickson, JD	1
Kaplan, DE	1
Blair, IA	1
Dangi, R	1
Hurkat, P	1
Jain, A	2
Shilpi, S	1
Gulbake, A	1
Jain, SK	1
Ouyang, H	1
Zhou, S	1
Li, J	3
Ye, Y	1
Nasr, M	1
Nafee, N	1
Saad, H	1
Kazem, A	1
Liu, KX	1
Zhang, CH	1
Jiang, N	1
Chu, QC	1
Guan, X	5
Fang, X	3
Zhou, D	1
Wang, Y	4
Gong, Y	1
Dong, G	1
Sun, Y	1
Rong, Y	1
Wang, D	3
Ran, H	3
Yang, N	2
Jiang, Y	3
Zhang, H	2
Sun, B	1
Hou, C	2
Zheng, J	2
Zuo, P	2
Kilcup, N	1
Tonkopi, E	1
Abraham, RJ	1
Boyd, D	1
Kehoe, S	1
Pagano, D	1
Tropea, A	1
Cintorino, D	1
Biondi, A	1
Spada, M	1
Gruttadauria, S	1
Hou, ZH	1
Zhao, WC	1
Zhang, Q	2
Zheng, W	1
Jiang, Z	1
Xiang, L	1
Ou, M	1
Shao, J	1
Lu, Y	2
Jia, L	1
Bishayee, K	1
Khuda-Bukhsh, AR	1
Huh, SO	1
Guo, W	1
Qiu, Z	1
Tan, N	1
Huang, S	1
Yao, M	1
He, X	1
Jiang, J	1
Chen, H	2
Yu, C	1
Tian, S	1
Sun, C	1
Pan, X	1
Wu, C	1
Gao, DY	1
Lin, TsT	1
Sung, YC	1
Liu, YC	1
Chiang, WH	1
Chang, CC	1
Liu, JY	1
Yin, Q	1
Qiao, C	1
Guo, Y	2
Ma, S	1
Liang, Z	1
Shi, J	1
Zhang, R	2
Li, D	1
Deng, S	4
Chen, F	1
Song, K	1
Kwon, H	1
Han, C	1
Dash, S	1
Lim, K	1
Wu, T	1
Cabral de Melo, FC	1
Borsato, D	1
de Macedo Júnior, FC	1
Mantovani, MS	1
Luiz, RC	1
Colabone-Celligoi, MA	1
Wu, B	1
Tan, Y	2
Xie, C	1
Shen, J	1
Liu, X	1
Zhang, F	1
Liu, L	1
Cai, S	1
Zheng, D	1
Tang, X	1
Sui, X	1
Lee, MJ	1
Lee, SJ	2
Yun, SJ	1
Jang, JY	1
Kang, H	1
Kim, K	1
Choi, IH	1
Park, S	1
Di-Wen, S	1
Pan, GZ	1
Hao, L	1
Xue, QZ	1
Wang, P	1
Yuan, QZ	1
Poojari, R	1
Srivastava, R	1
Panda, D	1
You, Y	1
Xu, J	1
Li, P	2
Chu, Q	1
Huo, X	1
Liu, K	1
An, T	1
Zhang, S	1
Yan, M	1
Solorio, L	1
Wu, H	3
Hernandez, C	1
Gangolli, M	1
Exner, AA	1
Gao, D	2
Alexandrino, H	1
Varela, AT	1
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