lactic acid has been researched along with Liver Failure in 22 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Liver Failure: Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum levels of AMMONIA; BILIRUBIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; LACTATE DEHYDROGENASES; and albumin/globulin ratio. (Blakiston's Gould Medical Dictionary, 4th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Critically ill patients who suffer from hepatic failure have elevated plasma arginine concentrations." | 7.72 | High plasma arginine concentrations in critically ill patients suffering from hepatic failure. ( Girbes, AR; Nijveldt, RJ; Prins, HA; Siroen, MP; Teerlink, T; van der Hoven, B; van Leeuwen, PA, 2004) |
| "We evaluated the ability of four biomarkers (C-Reactive protein (CRP), lactate, mid-regional proadrenomedullin (MR-proADM) and procalcitonin (PCT)) to detect each kind of organ failure considered in the SOFA in 213 patients with infection, sepsis or septic shock, by using multivariate regression analysis and calculation of the area under the receiver operating curve (AUROC)." | 3.96 | MR- proADM to detect specific types of organ failure in infection. ( Aldecoa, C; Almansa, R; Andaluz-Ojeda, D; Andrés, C; Bermejo-Martin, JF; Calvo, D; Cicuendez, R; Esteban-Velasco, MC; Martín, S; Martin-Fernandez, M; Muñoz-Bellvís, L; Nogales, L; Ríos-Llorente, A; Sanchez-Barrado, E; Vaquero-Roncero, LM, 2020) |
| "This study examined the effects of polyethylene oxide (PEO) on the survival rate, hemodynamics, blood gas indexes, lactic acid levels, microcirculation, and inflammatory cytokine levels in rats subjected to severe hemorrhagic shock." | 3.81 | Protective effects of polyethylene oxide on the vascular and organ function of rats with severe hemorrhagic shock. ( Dong, Z; Huang, T; Li, Q, 2015) |
| "The proposed discrimination methodology was applied to plasma and tissue (liver) metabolic profiling data describing the time progression of liver dysfunction in a rat model of acute hepatic failure generated by d-galactosamine (GalN) injection." | 3.72 | Identification of optimal classification functions for biological sample and state discrimination from metabolic profiling data. ( Hwang, D; Lee, K; Stephanopoulos, G; Stephanopoulos, GN; Yarmush, ML; Yokoyama, T, 2004) |
| "Critically ill patients who suffer from hepatic failure have elevated plasma arginine concentrations." | 3.72 | High plasma arginine concentrations in critically ill patients suffering from hepatic failure. ( Girbes, AR; Nijveldt, RJ; Prins, HA; Siroen, MP; Teerlink, T; van der Hoven, B; van Leeuwen, PA, 2004) |
| "Brain alterations such as hepatic encephalopathy or brain edema are usually associated with liver failure." | 2.50 | Magnetic resonance of the brain in chronic and acute liver failure. ( Chavarria, L; Cordoba, J, 2014) |
| "Here, we report on cytochrome c oxidase deficiency in the liver but not in the skeletal muscle of a 5-month-old girl who presented hepatic failure in early infancy." | 1.29 | Liver cytochrome c oxidase deficiency in a case of neonatal-onset hepatic failure. ( Cerrone, R; Chretien, D; Edery, P; Fabre, M; Gérard, B; Munnich, A; Rabier, D; Rambaud, C; Rötig, A; Saudubray, JM, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (18.18) | 18.2507 |
| 2000's | 10 (45.45) | 29.6817 |
| 2010's | 4 (18.18) | 24.3611 |
| 2020's | 4 (18.18) | 2.80 |
| Authors | Studies |
|---|---|
| Niederwieser, T | 1 |
| Braunwarth, E | 1 |
| Dasari, BVM | 1 |
| Pufal, K | 1 |
| Szatmary, P | 1 |
| Hackl, H | 1 |
| Haselmann, C | 1 |
| Connolly, CE | 1 |
| Cardini, B | 1 |
| Öfner, D | 1 |
| Roberts, K | 1 |
| Malik, H | 1 |
| Stättner, S | 1 |
| Primavesi, F | 1 |
| Shen, Q | 1 |
| Li, T | 1 |
| Zhou, J | 1 |
| Andrés, C | 1 |
| Andaluz-Ojeda, D | 1 |
| Cicuendez, R | 1 |
| Nogales, L | 1 |
| Martín, S | 1 |
| Martin-Fernandez, M | 1 |
| Almansa, R | 1 |
| Calvo, D | 1 |
| Esteban-Velasco, MC | 1 |
| Vaquero-Roncero, LM | 1 |
| Ríos-Llorente, A | 1 |
| Sanchez-Barrado, E | 1 |
| Muñoz-Bellvís, L | 1 |
| Aldecoa, C | 1 |
| Bermejo-Martin, JF | 1 |
| Popescu, M | 1 |
| Dima, S | 1 |
| Brasoveanu, V | 1 |
| Tudor, A | 1 |
| Simionescu, M | 1 |
| Tomescu, D | 1 |
| Freire Jorge, P | 1 |
| Wieringa, N | 1 |
| de Felice, E | 1 |
| van der Horst, ICC | 1 |
| Oude Lansink, A | 1 |
| Nijsten, MW | 1 |
| Chavarria, L | 1 |
| Cordoba, J | 1 |
| ffrench-O'Carroll, R | 1 |
| Frohlich, S | 1 |
| Murphy, N | 1 |
| Conlon, N | 1 |
| Li, Q | 1 |
| Huang, T | 1 |
| Dong, Z | 1 |
| Tofteng, F | 3 |
| Jorgensen, L | 1 |
| Hansen, BA | 1 |
| Ott, P | 1 |
| Kondrup, J | 2 |
| Larsen, FS | 4 |
| Herraiz, M | 1 |
| Beraza, N | 1 |
| Solano, A | 1 |
| Sangro, B | 1 |
| Montoya, J | 1 |
| Qian, C | 1 |
| Prieto, J | 1 |
| Bustos, M | 1 |
| Yamashita, Y | 1 |
| Shimada, M | 1 |
| Tsujita, E | 1 |
| Shirabe, K | 1 |
| Ijima, H | 1 |
| Nakazawa, K | 1 |
| Sakiyama, R | 1 |
| Fukuda, J | 1 |
| Funatsu, K | 1 |
| Sugimachi, K | 1 |
| Strauss, GI | 1 |
| Møller, K | 1 |
| Knudsen, GM | 1 |
| Lee, K | 1 |
| Hwang, D | 1 |
| Yokoyama, T | 1 |
| Stephanopoulos, G | 1 |
| Stephanopoulos, GN | 1 |
| Yarmush, ML | 1 |
| Nijveldt, RJ | 1 |
| Siroen, MP | 1 |
| van der Hoven, B | 1 |
| Teerlink, T | 1 |
| Prins, HA | 1 |
| Girbes, AR | 1 |
| van Leeuwen, PA | 1 |
| Dejong, CH | 1 |
| Deutz, NE | 1 |
| Soeters, PB | 1 |
| Edery, P | 1 |
| Gérard, B | 1 |
| Chretien, D | 1 |
| Rötig, A | 1 |
| Cerrone, R | 1 |
| Rabier, D | 1 |
| Rambaud, C | 1 |
| Fabre, M | 1 |
| Saudubray, JM | 2 |
| Munnich, A | 1 |
| Koebe, HG | 1 |
| Thasler, W | 1 |
| Schildberg, FW | 1 |
| Sokal, EM | 1 |
| Sokol, R | 1 |
| Cormier, V | 1 |
| Lacaille, F | 1 |
| McKiernan, P | 1 |
| Van Spronsen, FJ | 1 |
| Bernard, O | 1 |
| Feng, J | 1 |
| Li, X | 1 |
| Pei, F | 1 |
| Chen, X | 1 |
| Li, S | 1 |
| Nie, Y | 1 |
| Mora, N | 1 |
| Kaptanoglu, L | 1 |
| Zhang, Z | 1 |
| Niekrasz, M | 1 |
| Black, S | 1 |
| Ver Steeg, K | 1 |
| Wade, R | 1 |
| Siddall, V | 1 |
| Pao, W | 1 |
| Walsh, W | 1 |
| Ivancic, D | 1 |
| Kaufman, D | 1 |
| Abecassis, M | 1 |
| Stuart, F | 1 |
| Blei, A | 1 |
| Leventhal, J | 1 |
| Fryer, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Cerebral Microdialysis in Patients With Fulminant Hepatic Failure[NCT00836420] | 50 participants (Actual) | Observational | 2000-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for lactic acid and Liver Failure
| Article | Year |
|---|---|
Magnetic resonance of the brain in chronic and acute liver failure.
Topics: Aspartic Acid; Biomarkers; Brain; Brain Chemistry; Brain Edema; Choline; Creatine; Glutamic Acid; Gl | 2014 |
[Bio-artificial organ replacement of the liver].
Topics: Ammonia; Animals; Artificial Organs; Bioprosthesis; Cells, Cultured; Dogs; Extracorporeal Circulatio | 1993 |
20 other studies available for lactic acid and Liver Failure
| Article | Year |
|---|---|
Early postoperative arterial lactate concentrations to stratify risk of post-hepatectomy liver failure.
Topics: Aged; Austria; Biomarkers; Female; Hepatectomy; Humans; Incidence; Lactic Acid; Liver Failure; Male; | 2021 |
Comment on: Early postoperative arterial lactate concentrations to stratify risk of post-hepatectomy liver failure.
Topics: Hepatectomy; Humans; Lactic Acid; Liver Failure; Liver Function Tests; Postoperative Period | 2022 |
MR- proADM to detect specific types of organ failure in infection.
Topics: Adrenomedullin; Aged; Aged, 80 and over; Area Under Curve; Blood Coagulation Disorders; C-Reactive P | 2020 |
High perioperative lactate levels and decreased lactate clearance are associated with increased incidence of posthepatectomy liver failure.
Topics: Hepatectomy; Humans; Incidence; Lactic Acid; Liver Failure; Retrospective Studies | 2021 |
The association of early combined lactate and glucose levels with subsequent renal and liver dysfunction and hospital mortality in critically ill patients.
Topics: Adult; Aged; APACHE; Critical Illness; Female; Glucose; Hospital Mortality; Hospitalization; Humans; | 2017 |
Predictors of outcome in decompensated liver disease: validation of the SOFA-L score.
Topics: Critical Care; Hospital Mortality; Humans; Lactic Acid; Liver Failure; Organ Dysfunction Scores; Pro | 2015 |
Protective effects of polyethylene oxide on the vascular and organ function of rats with severe hemorrhagic shock.
Topics: Animals; Biomarkers; Disease Models, Animal; Fluid Therapy; Hemodynamics; Inflammation Mediators; In | 2015 |
Cerebral microdialysis in patients with fulminant hepatic failure.
Topics: Adult; Female; Glutamic Acid; Humans; Hyperventilation; Hypnotics and Sedatives; Hypothermia, Induce | 2002 |
Liver failure caused by herpes simplex virus thymidine kinase plus ganciclovir therapy is associated with mitochondrial dysfunction and mitochondrial DNA depletion.
Topics: Adenoviridae; Alanine Transaminase; Animals; Antigens, Tumor-Associated, Carbohydrate; Aspartate Ami | 2003 |
Efficacy of a larger version of the hybrid artificial liver support system using a polyurethane foam/spheroid packed-bed module in a warm ischemic liver failure pig model for preclinical experiments.
Topics: Amino Acids; Ammonia; Animals; Bile Acids and Salts; Culture Techniques; Extracorporeal Circulation; | 2003 |
Cerebral glucose and oxygen metabolism in patients with fulminant hepatic failure.
Topics: Acetoacetates; Brain; Humans; Lactic Acid; Liver Cirrhosis; Liver Failure; Oxygen; Oxygen Consumptio | 2003 |
Identification of optimal classification functions for biological sample and state discrimination from metabolic profiling data.
Topics: Algorithms; Amino Acids; Ammonia; Animals; Biomarkers; Diagnosis, Computer-Assisted; Galactosamine; | 2004 |
High plasma arginine concentrations in critically ill patients suffering from hepatic failure.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arginine; Critical Illness; Cross-Sectional Studies; Fem | 2004 |
The effect of indomethacin on intracranial pressure, cerebral perfusion and extracellular lactate and glutamate concentrations in patients with fulminant hepatic failure.
Topics: Adult; Blood Pressure; Brain; Brain Chemistry; Extracellular Space; Female; Glutamic Acid; Homeostas | 2004 |
Cerebral cortex ammonia and glutamine metabolism in two rat models of chronic liver insufficiency-induced hyperammonemia: influence of pair-feeding.
Topics: Amino Acids; Ammonia; Animals; Behavior, Animal; Bile Ducts; Cerebral Cortex; Chronic Disease; Eatin | 1993 |
Liver cytochrome c oxidase deficiency in a case of neonatal-onset hepatic failure.
Topics: Cytochrome-c Oxidase Deficiency; Female; Humans; Infant; Lactates; Lactic Acid; Liver; Liver Failure | 1994 |
Liver transplantation in mitochondrial respiratory chain disorders.
Topics: Electron Transport; Female; Humans; Hypoglycemia; Infant; Infant, Newborn; Lactic Acid; Liver Failur | 1999 |
1H NMR analysis for metabolites in serum and urine from rats administrated chronically with La(NO3)3.
Topics: Amino Acids; Animals; Citric Acid; Ethylamines; Ketone Bodies; Lactic Acid; Lanthanum; Liver Failure | 2002 |
Monitoring extracellular concentrations of lactate, glutamate, and glycerol by in vivo microdialysis in the brain during liver transplantation in acute liver failure.
Topics: Acute Disease; Adult; Brain; Extracellular Space; Glutamic Acid; Glycerol; Humans; Lactic Acid; Live | 2002 |
Single vs. dual vessel porcine extracorporeal liver perfusion.
Topics: Ammonia; Animals; Bile; Blood Pressure; Diuresis; Extracorporeal Circulation; Factor V; Female; Hear | 2002 |