lactic acid has been researched along with Liver Failure, Acute in 59 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Liver Failure, Acute: A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of HEPATOCYTES. It is characterized by sudden development of liver dysfunction and JAUNDICE. Acute liver failure may progress to exhibit cerebral dysfunction even HEPATIC COMA depending on the etiology that includes hepatic ISCHEMIA, drug toxicity, malignant infiltration, and viral hepatitis such as post-transfusion HEPATITIS B and HEPATITIS C.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Splenic rupture followed by lactic acidosis and hypoglycaemia should lead to suspicion of a cancer-mediated Warburg effect, and prompt urgent chemotherapy." | 8.31 | B-cell hepatosplenic lymphoma presenting in adult patient after spontaneous splenic rupture followed by severe persistent hypoglycaemia: type B lactic acidosis and acute liver failure. ( Gude, MF; Hamilton-Dutoit, S; Moen, M; Steiniche, T, 2023) |
| " Several patients with lactic acidosis and glucose levels below 1." | 7.80 | A patient with acute liver failure and extreme hypoglycaemia with lactic acidosis who was not in a coma: causes and consequences of lactate-protected hypoglycaemia. ( Gladden, LB; Goodwin, ML; McDonald, JR; Nijsten, MW; Oldenbeuving, G; Reijngoud, DJ; Sayilir, R, 2014) |
| "Data were collected early after admission and again at the time of onset of grade 3-4 hepatic encephalopathy from acetaminophen-induced fulminant hepatic failure." | 7.73 | Prognostic implications of hyperlactatemia, multiple organ failure, and systemic inflammatory response syndrome in patients with acetaminophen-induced acute liver failure. ( Larsen, FS; Schmidt, LE, 2006) |
| "Splenic rupture followed by lactic acidosis and hypoglycaemia should lead to suspicion of a cancer-mediated Warburg effect, and prompt urgent chemotherapy." | 4.31 | B-cell hepatosplenic lymphoma presenting in adult patient after spontaneous splenic rupture followed by severe persistent hypoglycaemia: type B lactic acidosis and acute liver failure. ( Gude, MF; Hamilton-Dutoit, S; Moen, M; Steiniche, T, 2023) |
| " Several patients with lactic acidosis and glucose levels below 1." | 3.80 | A patient with acute liver failure and extreme hypoglycaemia with lactic acidosis who was not in a coma: causes and consequences of lactate-protected hypoglycaemia. ( Gladden, LB; Goodwin, ML; McDonald, JR; Nijsten, MW; Oldenbeuving, G; Reijngoud, DJ; Sayilir, R, 2014) |
| "The pathogenesis of brain edema in an experimental model of ALF involves a cytotoxic mechanism: the metabolism of ammonia in astrocytes induces an increase of glutamine and lactate that appears to mediate cellular swelling." | 3.76 | Diffusion tensor imaging supports the cytotoxic origin of brain edema in a rat model of acute liver failure. ( Alonso, J; Chavarria, L; Cordoba, J; Lope-Piedrafita, S; Oria, M; Romero-Gimenez, J, 2010) |
| "Hyperammonemia causes brain edema and high intracranial pressure (ICP) in acute liver failure (ALF) by accumulation of glutamine in brain." | 3.74 | Cerebral glutamine concentration and lactate-pyruvate ratio in patients with acute liver failure. ( Bjerring, PN; Frederiksen, HJ; Hansen, BA; Hauerberg, J; Jorgensen, L; Larsen, FS; Tofteng, F, 2008) |
| "The most common causes of ALF were indeterminate liver failure (21%), acute hepatitis B (18%), acetaminophen ingestion (16%), and Budd-Chiari syndrome (9%)." | 3.74 | Prognostic implications of lactate, bilirubin, and etiology in German patients with acute liver failure. ( Bahr, MJ; Hadem, J; Klempnauer, J; Manns, MP; Rifai, K; Schneider, AS; Stiefel, P; Tillmann, HL; Wedemeyer, H, 2008) |
| "Data were collected early after admission and again at the time of onset of grade 3-4 hepatic encephalopathy from acetaminophen-induced fulminant hepatic failure." | 3.73 | Prognostic implications of hyperlactatemia, multiple organ failure, and systemic inflammatory response syndrome in patients with acetaminophen-induced acute liver failure. ( Larsen, FS; Schmidt, LE, 2006) |
| "Brain alterations such as hepatic encephalopathy or brain edema are usually associated with liver failure." | 2.50 | Magnetic resonance of the brain in chronic and acute liver failure. ( Chavarria, L; Cordoba, J, 2014) |
| "In patients with acute liver failure cerebral microdialysis studies show a linear correlation between the lactate to pyruvate ratio and the glutamine concentration, as well as to some of the adenosine triphosphate degradation products." | 2.49 | Changes in cerebral oxidative metabolism in patients with acute liver failure. ( Bjerring, PN; Larsen, FS, 2013) |
| "2." | 2.43 | Selection for acute liver failure: have we got it right? ( Blei, AT, 2005) |
| "There is increasing evidence that both acute liver failure and sepsis are accompanied by a hypermetabolic state in the hepatosplanchnic area, characterized by enhanced glycolysis and hyperlactatemia." | 2.42 | Splanchnic metabolism in acute liver failure and sepsis. ( Clemmesen, O; Larsen, FS; Ott, P, 2004) |
| "Massive cellular necrosis in acute liver failure (ALF) is dominantly immune mediated and innate immune cells are major pathophysiological determinants in liver damage." | 1.62 | Higher circulating natural killer cells and lower lactate levels at admission predict spontaneous survival in non-acetaminophen induced acute liver failure. ( Agrawal, T; Bajpai, M; Jagdish, RK; Maiwall, R; Rajan, V; Sarin, SK; Trehanpati, N, 2021) |
| " In a separate dose-response experiment cortex from healthy rats was incubated for 120 min in ammonium acetate in concentrations up to 80 mM prior to respirometry." | 1.46 | Accumulation of lactate in the rat brain during hyperammonaemia is not associated with impaired mitochondrial respiratory capacity. ( Bjerring, PN; Larsen, FS; Witt, AM, 2017) |
| "We investigated the association between hepatic encephalopathy (HE) scores, abnormal EEG or neuroimaging, and short-term outcome." | 1.40 | EEG abnormalities are associated with increased risk of transplant or poor outcome in children with acute liver failure. ( Alonso, E; Goldstein, J; Grimason, M; Hussain, E; Smith, CM; Wainwright, MS; Whitington, PF, 2014) |
| "Cerebral edema is a well-recognized and potentially fatal complication of acute liver failure (ALF)." | 1.39 | Cerebral microdialysis reflects the neuroprotective effect of fractionated plasma separation and adsorption in acute liver failure better and earlier than intracranial pressure: a controlled study in pigs. ( Koblihova, E; Laszikova, E; Pantoflicek, T; Prazak, J; Ryska, M; Ryska, O, 2013) |
| "Acetaminophen-induced acute liver failure (ALF) is a complex multiorgan illness." | 1.38 | Comparison of the sequential organ failure assessment score with the King's College Hospital criteria and the model for end-stage liver disease score for the prognosis of acetaminophen-induced acute liver failure. ( Agarwal, B; Betrosian, A; Burroughs, AK; Cholongitas, E; O'Beirne, J; Patch, D; Shaw, S; Theocharidou, E; Vasianopoulou, P, 2012) |
| "Seven patients with acute liver failure and high risk of intracranial hypertension were included for cerebral microdialysis and intracranial pressure monitoring." | 1.38 | The effect of fractionated plasma separation and adsorption on cerebral amino acid metabolism and oxidative metabolism during acute liver failure. ( Bjerring, PN; Clemmesen, JO; Frederiksen, HJ; Hauerberg, J; Larsen, FS; Nielsen, HB, 2012) |
| "Patients with acute liver failure (ALF) often die of intracranial pressure (IP) and cerebral herniation." | 1.37 | Brain region-selective mechanisms contribute to the progression of cerebral alterations in acute liver failure in rats. ( Agusti, A; Boix, J; Cauli, O; Cerdán, S; Felipo, V; López-Larrubia, P; Nieto-Charques, L; Rodrigo, R, 2011) |
| "The pathogenesis of cerebral edema in acute liver failure is suggested, in in vitro and animal studies, to involve a compromised oxidative metabolism with a decrease in cerebral ATP levels and an increase in purine concentrations." | 1.36 | Brain hypoxanthine concentration correlates to lactate/pyruvate ratio but not intracranial pressure in patients with acute liver failure. ( Bjerring, PN; Frederiksen, HJ; Hansen, BA; Hauerberg, J; Jørgensen, L; Larsen, FS; Tofteng, F, 2010) |
| "Acute liver failure is often accompanied by hyperdynamic circulation, which is also a characteristic of septic shock." | 1.35 | Hemodynamics and metabolic studies on septic shock in patients with acute liver failure. ( Chen, PC; Chen, YC; Chu, YY; Fang, JT; Lien, JM; Peng, YS; Tang, JH; Tian, YC; Tsai, MH; Wu, CS; Yang, C, 2008) |
| "We previously demonstrated in pigs with acute liver failure (ALF) that albumin dialysis using the molecular adsorbents recirculating system (MARS) attenuated a rise in intracranial pressure (ICP)." | 1.34 | Association of reduced extracellular brain ammonia, lactate, and intracranial pressure in pigs with acute liver failure. ( Belanger, M; Davies, NA; Jalan, R; Nedredal, GI; Revhaug, A; Rose, C; Sen, S; Ytrebø, LM, 2007) |
| "Fulminant hepatic encephalopathy has a high mortality." | 1.33 | Microdialysis in the management of hepatic encephalopathy. ( Al-Rawi, PG; Czosnyka, M; Gimson, A; Hutchinson, PJ; Menon, DK; O'Connell, MT, 2006) |
| "Hepatocyte regeneration in acute hepatic failure is essential for recovery, but requires a large amount of energy." | 1.29 | Plasma exchange and the arterial blood ketone body ratio in patients with acute hepatic failure. ( Maeda, T; Onishi, S; Saibara, T; Yamamoto, Y, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (1.69) | 18.2507 |
| 2000's | 23 (38.98) | 29.6817 |
| 2010's | 31 (52.54) | 24.3611 |
| 2020's | 4 (6.78) | 2.80 |
| Authors | Studies |
|---|---|
| Alhadab, A | 1 |
| AlShihabi, H | 1 |
| Mohamed, F | 1 |
| AlDuhilib, Z | 1 |
| Arain, Z | 1 |
| Bader, R | 1 |
| Moen, M | 1 |
| Hamilton-Dutoit, S | 1 |
| Steiniche, T | 1 |
| Gude, MF | 1 |
| Figueira, ERR | 1 |
| Rocha-Filho, JA | 1 |
| Lanchotte, C | 1 |
| Nacif, LS | 1 |
| de Paiva Haddad, LB | 1 |
| Assalin, AR | 1 |
| Shinkado, YR | 1 |
| Vintimilla, AM | 1 |
| Galvao, FHF | 1 |
| D'Albuquerque, LAC | 1 |
| Agrawal, T | 1 |
| Maiwall, R | 1 |
| Rajan, V | 1 |
| Bajpai, M | 1 |
| Jagdish, RK | 1 |
| Sarin, SK | 1 |
| Trehanpati, N | 1 |
| Wei, YL | 1 |
| Tian, Q | 1 |
| Zhao, XX | 1 |
| Qiu, GZ | 1 |
| Xu, Y | 1 |
| Sasaki, K | 1 |
| Sakamoto, S | 1 |
| Uchida, H | 1 |
| Narumoto, S | 1 |
| Shigeta, T | 1 |
| Fukuda, A | 1 |
| Ito, R | 1 |
| Irie, R | 1 |
| Yoshioka, T | 1 |
| Murayama, K | 1 |
| Kasahara, M | 1 |
| Michard, B | 1 |
| Artzner, T | 1 |
| Lebas, B | 1 |
| Besch, C | 1 |
| Guillot, M | 1 |
| Faitot, F | 1 |
| Lefebvre, F | 1 |
| Bachellier, P | 1 |
| Castelain, V | 1 |
| Maestraggi, Q | 1 |
| Schneider, F | 1 |
| Prazak, J | 2 |
| Laszikova, E | 2 |
| Pantoflicek, T | 2 |
| Ryska, O | 2 |
| Koblihova, E | 2 |
| Ryska, M | 2 |
| Chavarria, L | 3 |
| Cordoba, J | 3 |
| Hussain, E | 1 |
| Grimason, M | 1 |
| Goldstein, J | 1 |
| Smith, CM | 1 |
| Alonso, E | 1 |
| Whitington, PF | 1 |
| Wainwright, MS | 1 |
| Amathieu, R | 1 |
| Triba, MN | 1 |
| Nahon, P | 1 |
| Bouchemal, N | 1 |
| Kamoun, W | 1 |
| Haouache, H | 1 |
| Trinchet, JC | 1 |
| Savarin, P | 1 |
| Le Moyec, L | 1 |
| Dhonneur, G | 1 |
| Chang, RA | 1 |
| Chen, Z | 1 |
| Li, ZF | 1 |
| Oldenbeuving, G | 1 |
| McDonald, JR | 1 |
| Goodwin, ML | 1 |
| Sayilir, R | 1 |
| Reijngoud, DJ | 1 |
| Gladden, LB | 1 |
| Nijsten, MW | 1 |
| Romero-Giménez, J | 2 |
| Monteagudo, E | 1 |
| Lope-Piedrafita, S | 2 |
| Maharaj, R | 1 |
| Pingitore, A | 1 |
| Menon, K | 1 |
| Kane, P | 1 |
| Wendon, J | 1 |
| Bernal, W | 3 |
| Liu, M | 1 |
| Yang, J | 1 |
| Hu, W | 1 |
| Zhang, S | 1 |
| Wang, Y | 1 |
| Hertz, L | 1 |
| Song, D | 1 |
| Peng, L | 1 |
| Chen, Y | 1 |
| Özçay, F | 1 |
| Karadağ Öncel, E | 1 |
| Barış, Z | 1 |
| Canan, O | 1 |
| Moray, G | 1 |
| Haberal, M | 1 |
| Witt, AM | 1 |
| Larsen, FS | 10 |
| Bjerring, PN | 5 |
| Feldman, AG | 1 |
| Sokol, RJ | 1 |
| Hardison, RM | 1 |
| Alonso, EM | 1 |
| Squires, RH | 1 |
| Narkewicz, MR | 1 |
| Tsai, MH | 1 |
| Chen, YC | 1 |
| Lien, JM | 1 |
| Tian, YC | 1 |
| Peng, YS | 1 |
| Fang, JT | 1 |
| Yang, C | 1 |
| Tang, JH | 1 |
| Chu, YY | 1 |
| Chen, PC | 1 |
| Wu, CS | 1 |
| Novelli, G | 1 |
| Rossi, M | 1 |
| Ferretti, G | 1 |
| Pugliese, F | 1 |
| Ruberto, F | 1 |
| Lai, Q | 1 |
| Novelli, S | 1 |
| Piemonte, V | 1 |
| Turchetti, L | 1 |
| Morabito, V | 1 |
| Annesini, MC | 1 |
| Berloco, PB | 1 |
| Oria, M | 1 |
| Alonso, J | 1 |
| Du, WB | 1 |
| Pan, XP | 1 |
| Li, LJ | 1 |
| Schmidt, LE | 2 |
| Kjelland, CB | 1 |
| Djogovic, D | 1 |
| Hauerberg, J | 4 |
| Jørgensen, L | 1 |
| Frederiksen, HJ | 4 |
| Tofteng, F | 2 |
| Hansen, BA | 3 |
| Westbrook, RH | 1 |
| Yeoman, AD | 1 |
| Joshi, D | 1 |
| Heaton, ND | 2 |
| Quaglia, A | 1 |
| O'Grady, JG | 1 |
| Auzinger, G | 1 |
| Heneghan, MA | 1 |
| Wendon, JA | 2 |
| Cauli, O | 1 |
| López-Larrubia, P | 1 |
| Rodrigo, R | 1 |
| Agusti, A | 1 |
| Boix, J | 1 |
| Nieto-Charques, L | 1 |
| Cerdán, S | 1 |
| Felipo, V | 1 |
| Dabos, KJ | 1 |
| Whalen, HR | 1 |
| Newsome, PN | 1 |
| Parkinson, JA | 1 |
| Henderson, NC | 1 |
| Sadler, IH | 1 |
| Hayes, PC | 1 |
| Plevris, JN | 1 |
| Cholongitas, E | 2 |
| Theocharidou, E | 1 |
| Vasianopoulou, P | 1 |
| Betrosian, A | 1 |
| Shaw, S | 3 |
| Patch, D | 3 |
| O'Beirne, J | 2 |
| Agarwal, B | 1 |
| Burroughs, AK | 3 |
| Nielsen, HB | 1 |
| Clemmesen, JO | 1 |
| Li, GZ | 1 |
| Wang, ZH | 1 |
| Cui, W | 1 |
| Fu, JL | 1 |
| Wang, YR | 1 |
| Liu, P | 1 |
| Roy, P | 1 |
| Das, S | 1 |
| Auddy, RG | 1 |
| Saha, A | 1 |
| Mukherjee, A | 1 |
| Zwingmann, C | 2 |
| Chatauret, N | 4 |
| Leibfritz, D | 2 |
| Butterworth, RF | 4 |
| Rose, C | 4 |
| van de Kerkhove, MP | 1 |
| Di Florio, E | 1 |
| Scuderi, V | 1 |
| Mancini, A | 1 |
| Belli, A | 1 |
| Bracco, A | 1 |
| Scala, D | 1 |
| Scala, S | 1 |
| Zeuli, L | 1 |
| Di Nicuolo, G | 1 |
| Amoroso, P | 1 |
| Calise, F | 1 |
| Chamuleau, RA | 1 |
| Clemmesen, O | 1 |
| Ott, P | 1 |
| Lee, KU | 1 |
| Zheng, LX | 1 |
| Cho, YB | 1 |
| Kim, KH | 1 |
| Ha, J | 1 |
| Suh, KS | 1 |
| Jung, SE | 1 |
| Macquillan, GC | 2 |
| Seyam, MS | 1 |
| Nightingale, P | 1 |
| Neuberger, JM | 1 |
| Murphy, N | 1 |
| Blei, AT | 1 |
| Cholongitas, EB | 1 |
| Betrossian, A | 2 |
| Leandro, G | 1 |
| Hutchinson, PJ | 1 |
| Gimson, A | 1 |
| Al-Rawi, PG | 1 |
| O'Connell, MT | 1 |
| Czosnyka, M | 1 |
| Menon, DK | 1 |
| Eefsen, M | 1 |
| Dethloff, T | 1 |
| Ytrebø, LM | 1 |
| Davies, NA | 1 |
| Sen, S | 1 |
| Nedredal, GI | 1 |
| Belanger, M | 1 |
| Revhaug, A | 1 |
| Jalan, R | 1 |
| Gow, PJ | 1 |
| Warrilow, S | 1 |
| Lontos, S | 1 |
| Lubel, J | 1 |
| Wongseelashote, S | 1 |
| Jones, RM | 1 |
| Bellomo, R | 1 |
| Angus, PW | 1 |
| Senzolo, M | 1 |
| Jorgensen, L | 1 |
| Hadem, J | 1 |
| Stiefel, P | 1 |
| Bahr, MJ | 1 |
| Tillmann, HL | 1 |
| Rifai, K | 1 |
| Klempnauer, J | 1 |
| Wedemeyer, H | 1 |
| Manns, MP | 1 |
| Schneider, AS | 1 |
| Saibara, T | 1 |
| Maeda, T | 1 |
| Onishi, S | 1 |
| Yamamoto, Y | 1 |
| Pere, P | 1 |
| Höckerstedt, K | 1 |
| Isoniemi, H | 1 |
| Lindgren, L | 1 |
| Murphy, ND | 1 |
| Kodakat, SK | 1 |
| Jooste, CA | 1 |
| Muiesan, P | 1 |
| Rela, M | 1 |
| Therrien, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multi-Center Group to Study Acute Liver Failure in Children[NCT00986648] | 158 participants (Actual) | Observational | 2000-01-31 | Completed | |||
| Cerebral Microdialysis in Patients With Fulminant Hepatic Failure[NCT00836420] | 50 participants (Actual) | Observational | 2000-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for lactic acid and Liver Failure, Acute
| Article | Year |
|---|---|
Magnetic resonance of the brain in chronic and acute liver failure.
Topics: Aspartic Acid; Biomarkers; Brain; Brain Chemistry; Brain Edema; Choline; Creatine; Glutamic Acid; Gl | 2014 |
Multifactorial Effects on Different Types of Brain Cells Contribute to Ammonia Toxicity.
Topics: Ammonia; Animals; Astrocytes; Brain; Cyclic GMP; Energy Metabolism; Glutamine; Hepatic Encephalopath | 2017 |
Prognostic models for acute liver failure.
Topics: alpha-Fetoproteins; Ammonia; Humans; Lactic Acid; Liver Failure, Acute; Models, Biological; Phosphat | 2010 |
The role of serum lactate in the acute care setting.
Topics: Acidosis, Lactic; Adult; Aged; Antiretroviral Therapy, Highly Active; Biomarkers; Critical Care; Dru | 2010 |
Changes in cerebral oxidative metabolism in patients with acute liver failure.
Topics: Amino Acids; Ammonia; Animals; Brain; Brain Chemistry; Humans; Hyperammonemia; Lactic Acid; Liver Fa | 2013 |
Splanchnic metabolism in acute liver failure and sepsis.
Topics: Humans; Ketone Bodies; Lactic Acid; Liver Failure, Acute; Oxygen Consumption; Sepsis; Splanchnic Cir | 2004 |
Selection for acute liver failure: have we got it right?
Topics: alpha-Fetoproteins; Biomarkers; Decision Making; Graft Survival; Humans; Lactic Acid; Liver Failure, | 2005 |
1 trial available for lactic acid and Liver Failure, Acute
| Article | Year |
|---|---|
Bridging a patient with acute liver failure to liver transplantation by the AMC-bioartificial liver.
Topics: Adult; Ammonia; Animals; Bilirubin; Female; Hepatitis B; Hepatocytes; Humans; Lactic Acid; Liver Fai | 2003 |
51 other studies available for lactic acid and Liver Failure, Acute
| Article | Year |
|---|---|
Pediatric acute liver failure in Saudi Arabia: prognostic indicators, outcomes and the role of genetic testing.
Topics: Child; Genetic Testing; Humans; Lactic Acid; Liver Failure, Acute; Prognosis; Retrospective Studies; | 2023 |
B-cell hepatosplenic lymphoma presenting in adult patient after spontaneous splenic rupture followed by severe persistent hypoglycaemia: type B lactic acidosis and acute liver failure.
Topics: Acidosis, Lactic; Adult; Humans; Hypoglycemia; Lactic Acid; Liver Failure, Acute; Lymphoma, Non-Hodg | 2023 |
Creatinine-lactate score predicts mortality in non-acetaminophen-induced acute liver failure in patients listed for liver transplantation.
Topics: Adult; Creatinine; Female; Humans; Lactic Acid; Liver Failure, Acute; Liver Transplantation; Male; M | 2021 |
Higher circulating natural killer cells and lower lactate levels at admission predict spontaneous survival in non-acetaminophen induced acute liver failure.
Topics: Adult; Female; Humans; Killer Cells, Natural; Lactic Acid; Liver Failure, Acute; Male; Middle Aged; | 2021 |
Association between MFN2 gene polymorphisms and the risk and prognosis of acute liver failure: a case-control study in a Chinese population.
Topics: Adult; Ammonia; Asian People; Case-Control Studies; China; Female; Gene Frequency; Genetic Predispos | 2017 |
Liver Transplantation for Mitochondrial Respiratory Chain Disorder: A Single-Center Experience and Excellent Marker of Differential Diagnosis.
Topics: Adult; Biomarkers; Diagnosis, Differential; Female; Humans; Lactic Acid; Liver Failure, Acute; Liver | 2017 |
Liver transplantation in critically ill patients: Preoperative predictive factors of post-transplant mortality to avoid futility.
Topics: Adult; Critical Illness; Female; Follow-Up Studies; Graft Rejection; Humans; Lactic Acid; Liver Fail | 2017 |
Cerebral microdialysis reflects the neuroprotective effect of fractionated plasma separation and adsorption in acute liver failure better and earlier than intracranial pressure: a controlled study in pigs.
Topics: Ammonia; Animals; Brain Edema; Cerebrum; Extracorporeal Circulation; Glucose; Glutamic Acid; Glutami | 2013 |
EEG abnormalities are associated with increased risk of transplant or poor outcome in children with acute liver failure.
Topics: Alanine Transaminase; Aspartate Aminotransferases; Child; Child, Preschool; Electroencephalography; | 2014 |
Serum 1H-NMR metabolomic fingerprints of acute-on-chronic liver failure in intensive care unit patients with alcoholic cirrhosis.
Topics: Biomarkers; Creatinine; Glutamine; Humans; Intensive Care Units; Ketone Bodies; Lactic Acid; Liver C | 2014 |
Role of HGF-loaded nanoparticles in treating rat acute hepatic failure.
Topics: Animals; Biomarkers; Cells, Cultured; Chemistry, Pharmaceutical; Chitosan; Delayed-Action Preparatio | 2013 |
A patient with acute liver failure and extreme hypoglycaemia with lactic acidosis who was not in a coma: causes and consequences of lactate-protected hypoglycaemia.
Topics: Acetaminophen; Acidosis, Lactic; Analgesics, Non-Narcotic; Blood Glucose; Follow-Up Studies; Humans; | 2014 |
Real-time assessment of ¹³C metabolism reveals an early lactate increase in the brain of rats with acute liver failure.
Topics: Alanine; Animals; Brain; Carbon; Carbon Isotopes; Computer Systems; Disease Progression; Lactic Acid | 2015 |
Images of the Month: MDMA-Induced Acute Liver Failure and Transient Abdominal Pneumatosis.
Topics: Adult; Female; Heart; Humans; Ileus; Kidney; Lactic Acid; Liver; Liver Failure, Acute; N-Methyl-3,4- | 2015 |
Superior performance of co-cultured mesenchymal stem cells and hepatocytes in poly(lactic acid-glycolic acid) scaffolds for the treatment of acute liver failure.
Topics: Animals; Biocompatible Materials; Cell Differentiation; Cell Survival; Cells, Cultured; Coculture Te | 2016 |
Etiologies, outcomes, and prognostic factors of pediatric acute liver failure: A single center's experience in Turkey.
Topics: Adolescent; Ammonia; Bilirubin; Blood Coagulation Tests; Child; Child, Preschool; Female; Hepatitis | 2016 |
Accumulation of lactate in the rat brain during hyperammonaemia is not associated with impaired mitochondrial respiratory capacity.
Topics: Animals; Biosensing Techniques; Brain Chemistry; Cerebral Cortex; Citric Acid Cycle; Encephalitis; H | 2017 |
Lactate and Lactate: Pyruvate Ratio in the Diagnosis and Outcomes of Pediatric Acute Liver Failure.
Topics: Adolescent; Age Factors; Biomarkers; Child; Child, Preschool; Cohort Studies; Female; Humans; Lactic | 2017 |
Hemodynamics and metabolic studies on septic shock in patients with acute liver failure.
Topics: Aldosterone; APACHE; Blood Gas Analysis; Female; Hemodynamics; Hepatitis B; Hospital Mortality; Huma | 2008 |
Predictive criteria for the outcome of patients with acute liver failure treated with the albumin dialysis molecular adsorbent recirculating system.
Topics: Adult; Albumins; Critical Care; Cytokines; Dialysis; Female; Hemodynamics; Humans; Lactic Acid; Live | 2009 |
Diffusion tensor imaging supports the cytotoxic origin of brain edema in a rat model of acute liver failure.
Topics: Ammonia; Animals; Astrocytes; Blood-Brain Barrier; Brain; Brain Edema; Diffusion Tensor Imaging; Glu | 2010 |
Is lactate concentration of major value in determining the prognosis in patients with acute liver failure? Hardly.
Topics: Acetaminophen; Humans; Lactic Acid; Liver Failure, Acute; Liver Transplantation; Patient Selection; | 2010 |
Lactate is important in determining prognosis in acute liver failure.
Topics: Humans; Lactic Acid; Liver Failure, Acute; Liver Transplantation; Patient Selection; Prognosis | 2010 |
Brain hypoxanthine concentration correlates to lactate/pyruvate ratio but not intracranial pressure in patients with acute liver failure.
Topics: Adolescent; Adult; Brain; Brain Edema; Female; Humans; Hyperammonemia; Hypoxanthine; Inosine; Intrac | 2010 |
Outcomes of severe pregnancy-related liver disease: refining the role of transplantation.
Topics: Adult; Fatty Liver; Female; Humans; Hypertension, Pregnancy-Induced; Lactic Acid; Liver Diseases; Li | 2010 |
Brain region-selective mechanisms contribute to the progression of cerebral alterations in acute liver failure in rats.
Topics: Ammonia; Animals; Blood-Brain Barrier; Brain Edema; Capillary Permeability; Cerebellum; Cerebrum; En | 2011 |
Impaired gluconeogenesis in a porcine model of paracetamol induced acute liver failure.
Topics: Acetaminophen; Amino Acids; Animals; Biomarkers; Citric Acid Cycle; Disease Models, Animal; Gluconeo | 2011 |
Comparison of the sequential organ failure assessment score with the King's College Hospital criteria and the model for end-stage liver disease score for the prognosis of acetaminophen-induced acute liver failure.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; APACHE; Biomarkers; Chemical and Drug Induced Liver | 2012 |
Artificial liver support system reduces intracranial pressure more effectively than bioartificial system: an experimental study.
Topics: Ammonia; Animals; Bilirubin; Biomarkers; Cerebrovascular Circulation; Disease Models, Animal; Equipm | 2012 |
The effect of fractionated plasma separation and adsorption on cerebral amino acid metabolism and oxidative metabolism during acute liver failure.
Topics: Adult; Amino Acids; Cerebrum; Dialysis Solutions; Extracorporeal Circulation; Female; Glutamine; Hep | 2012 |
Tumor necrosis factor alpha increases intestinal permeability in mice with fulminant hepatic failure.
Topics: Animals; Claudin-1; Colon; Intestinal Mucosa; Lactic Acid; Liver Failure, Acute; Male; Mice; Mice, I | 2012 |
Engineered andrographolide nanoparticles mitigate paracetamol hepatotoxicity in mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents; Diterpenes; Heparin; Lac | 2013 |
Selective increase of brain lactate synthesis in experimental acute liver failure: results of a [H-C] nuclear magnetic resonance study.
Topics: Amino Acids; Ammonia; Animals; Blood; Body Water; Brain; Brain Edema; Carbon Isotopes; Glucose; Hepa | 2003 |
Mild hypothermia in the prevention of brain edema in acute liver failure: mechanisms and clinical prospects.
Topics: Ammonia; Brain; Brain Edema; Glutamic Acid; Humans; Hypothermia, Induced; Lactic Acid; Liver Failure | 2002 |
Effects of hypothermia on brain glucose metabolism in acute liver failure: a H/C-nuclear magnetic resonance study.
Topics: Alanine; Amino Acids; Animals; Brain; Citric Acid Cycle; Glucose; Hypothermia, Induced; Lactic Acid; | 2003 |
An experimental animal model of fulminant hepatic failure in pigs.
Topics: Acidosis; Ammonia; Animals; Aspartate Aminotransferases; Bilirubin; Blood Glucose; Blood Urea Nitrog | 2005 |
Blood lactate but not serum phosphate levels can predict patient outcome in fulminant hepatic failure.
Topics: Adult; Biomarkers; Female; Humans; Lactic Acid; Liver Failure, Acute; Liver Transplantation; Male; M | 2005 |
Prognostic implications of hyperlactatemia, multiple organ failure, and systemic inflammatory response syndrome in patients with acetaminophen-induced acute liver failure.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Child; Female; Hepatic Encephalopa | 2006 |
King's criteria, APACHE II, and SOFA scores in acute liver failure.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; APACHE; Female; Humans; Lactic Acid; Liver Failure, | 2006 |
Is it worthwhile to use cerebral microdialysis in patients with acute liver failure?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Blood Glucose; Bra | 2006 |
Microdialysis in the management of hepatic encephalopathy.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Blood Glucose; Brain; Brain Edema; Critical Care; Dextropro | 2006 |
Comparison of terlipressin and noradrenalin on cerebral perfusion, intracranial pressure and cerebral extracellular concentrations of lactate and pyruvate in patients with acute liver failure in need of inotropic support.
Topics: Adolescent; Adult; Brain; Cerebrovascular Circulation; Extracellular Fluid; Female; Humans; Intracra | 2007 |
Association of reduced extracellular brain ammonia, lactate, and intracranial pressure in pigs with acute liver failure.
Topics: Ammonia; Animals; Brain Chemistry; Disease Models, Animal; Extracellular Space; Female; Glutamic Aci | 2007 |
Time to review the selection criteria for transplantation in paracetamol-induced fulminant hepatic failure?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Biomarkers; Humans; Lactic Acid; Liver Failure, Acute; Live | 2007 |
Prognostic impact of lactate in acute liver failure.
Topics: Adult; Biomarkers; Female; Follow-Up Studies; Humans; Lactic Acid; Liver Failure, Acute; Male; Progn | 2008 |
Cerebral glutamine concentration and lactate-pyruvate ratio in patients with acute liver failure.
Topics: Adolescent; Adult; Aged; Astrocytes; Brain; Brain Edema; Critical Care; Female; Glutamine; Humans; H | 2008 |
Prognostic implications of lactate, bilirubin, and etiology in German patients with acute liver failure.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Bilirubin; Biomarkers; Budd-Chiari | 2008 |
Plasma exchange and the arterial blood ketone body ratio in patients with acute hepatic failure.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adult; Aged; Arteries; Child; Citrates; Citric Acid; Female; H | 1994 |
Cerebral blood flow and oxygenation in liver transplantation for acute or chronic hepatic disease without venovenous bypass.
Topics: Adolescent; Adult; Aged; Anesthesia, General; Blood Flow Velocity; Brain; Cerebrovascular Circulatio | 2000 |
Liver and intestinal lactate metabolism in patients with acute hepatic failure undergoing liver transplantation.
Topics: Female; Hepatic Veins; Humans; International Normalized Ratio; Intestinal Mucosa; Lactic Acid; Liver | 2001 |
Mild hypothermia prevents cerebral edema and CSF lactate accumulation in acute liver failure.
Topics: Ammonia; Animals; Brain; Brain Edema; Energy Metabolism; Hepatic Encephalopathy; Hypothermia, Induce | 2001 |