lactic acid has been researched along with Liver Cirrhosis in 70 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Liver Cirrhosis: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of amrinone, a selective phosphodiesterase III inhibitor, on liver ischaemia reperfusion injury have not yet been clarified." | 9.09 | Effects of amrinone on ischaemia-reperfusion injury in cirrhotic patients undergoing hepatectomy: a comparative study with prostaglandin E1. ( Chang, K; Hanaoka, K; Hayashida, M; Makuuchi, M; Orii, R; Sugawara, Y; Takayama, T; Yamada, Y, 2000) |
| "Methylene blue (MB) has been used as a vasopressor in sepsis and acute liver failure." | 6.70 | The effect of methylene blue on the hemodynamic changes during ischemia reperfusion injury in orthotopic liver transplantation. ( Baumann, J; Bellamy, MC; Gedney, JA; Koelzow, H; Snook, NJ, 2002) |
| "The effects of amrinone, a selective phosphodiesterase III inhibitor, on liver ischaemia reperfusion injury have not yet been clarified." | 5.09 | Effects of amrinone on ischaemia-reperfusion injury in cirrhotic patients undergoing hepatectomy: a comparative study with prostaglandin E1. ( Chang, K; Hanaoka, K; Hayashida, M; Makuuchi, M; Orii, R; Sugawara, Y; Takayama, T; Yamada, Y, 2000) |
| "None of the patients developed lactic acidosis during follow-up [median: 58 (6-155) months]." | 3.85 | Lactate serum concentrations during treatment with nucleos(t)ide analogues in hepatitis B with or without cirrhosis. ( Aggeletopoulou, I; Anastassiou, ED; Assimakopoulos, S; Gogos, C; Kalafateli, M; Labropoulou-Karatza, C; Mandellou, M; Taprantzi, D; Thomopoulos, K; Triantos, C; Tselekouni, P; Tsiaoussis, G; Vourli, G, 2017) |
| "Patients had net metabolic acidosis owing to unmeasured anions and owing to hyperchloraemic, dilutional and lactic acidosis." | 3.74 | Acid-base disturbances in critically ill patients with cirrhosis. ( Doberer, D; Funk, GC; Holzinger, U; Kneidinger, N; Lindner, G; Schneeweiss, B, 2007) |
| " However, we experienced a patient with liver cirrhosis (LC, Child-Pugh class B) in whom severe lactic acidosis developed during RFA conducted for the treatment of a HCC (-4." | 3.71 | [Changes in acid-base balance and blood lactate levels during radio frequency ablation conducted for the treatment of hepatocellular carcinomata in patients with liver cirrhosis]. ( Akata, T; Kandabashi, T; Kanna, T; Shiokawa, H; Takahashi, S; Yoshino, J, 2002) |
| " Hyperglycemia-induced increases of plasma C-peptide concentrations were comparable to those in controls (p = NS)." | 3.69 | Pathogenesis of glucose intolerance and diabetes mellitus in cirrhosis. ( Matthews, D; Petrides, AS; Schulze-Berge, D; Strohmeyer, G; Vogt, C, 1994) |
| "By central venous catheterization, 6 control persons, 7 patients with liver cirrhosis and 6 patients with diabetes mellitus were infused for 48 h with a 20% (w/v) mixture of glucose/xylitol (1:1)." | 3.66 | [Carbohydrate infusion in internal diseases. A comparative study in metabolically healthy, liver diseased and diabetic patients. VI. Infusions of a glucose/xylitol mixture (1:1 ratio) over a 48-hour period]. ( Egberts, EH; Horbach, L; Malchow, H; Müller, PH; Prestele, H; Rittershofer, H; Schmülling, R, 1982) |
| "Cirrhotics with septic shock underwent open label randomization to receive either terlipressin (n=42) or noradrenaline (n=42) infusion at a titrated dose." | 2.84 | A randomized trial comparing terlipressin and noradrenaline in patients with cirrhosis and septic shock. ( Bhadoria, AS; Choudhury, A; Joshi, YK; Kedarisetty, CK; Kumar, G; Kumar, S; Maiwall, R; Saini, D; Sarin, SK; Sharma, MK; Vashishtha, C, 2017) |
| "Methylene blue (MB) has been used as a vasopressor in sepsis and acute liver failure." | 2.70 | The effect of methylene blue on the hemodynamic changes during ischemia reperfusion injury in orthotopic liver transplantation. ( Baumann, J; Bellamy, MC; Gedney, JA; Koelzow, H; Snook, NJ, 2002) |
| "0 g/dL, serum lactate concentration greater than or equal to 2 mmol/L, MAP less than 60 mmHg, or vasopressor dosage between 0." | 1.91 | Identification of indications for albumin administration in septic patients with liver cirrhosis. ( Chen, H; Hu, W; Huang, W; Huang, Y; Ma, C; Peng, Q; Sun, Q; Wang, H; Wang, J; Xie, J; Yang, M; Zhang, C, 2023) |
| "All patients with a diagnosis of liver cirrhosis and septic shock were enrolled." | 1.62 | Effectiveness of sepsis bundle application and outcomes predictors to cirrhotic patients with septic shock. ( Hsu, YC; Yang, YY, 2021) |
| "Twenty-nine patients with chronic hepatitis B (CHB), 28 with compensated LC, 33 with decompensated LC, 24 with spontaneous bacterial peritonitis (SBP), 26 with acute-on-chronic liver failure (ACLF), and 24 with decompensated LC complicated by hepatocellular carcinoma (HCC) were recruited." | 1.51 | Plasma claudin-3 is associated with tumor necrosis factor-alpha-induced intestinal endotoxemia in liver disease. ( Biviano, I; Gong, Z; Hu, J; Liu, H; Wang, A; Wang, Z, 2019) |
| "Sorafenib is a tyrosine kinase inhibitor that has recently been shown to be a potential antifibrotic agent." | 1.43 | Development and characterization of sorafenib-loaded PLGA nanoparticles for the systemic treatment of liver fibrosis. ( Chen, Y; Chiang, T; Gao, DY; Lin, TsT; Liu, JY; Liu, YC; Sung, YC; Wan, D; Wang, L, 2016) |
| "Acute mesenteric ischemia is a rare but often fatal complication following cardiovascular surgery." | 1.43 | Acute mesenteric ischemia following cardiovascular surgery--A nested case-control study. ( Bayer, O; Doenst, T; Hein, HA; Kabisch, B; Koeppen, J; Mothes, H; Richter, M; Schwarzkopf, D; Settmacher, U; Zanow, J, 2016) |
| "Fifty liver cirrhosis patients were enrolled into experimental group and 30 healthy people into control group." | 1.32 | Changes of plasma D(-)-lactate, diamine oxidase and endotoxin in patients with liver cirrhosis. ( Gong, ZJ; Ruan, P; Zhang, QR, 2004) |
| "The optimal dichloroacetate pharmacokinetic model for both subjects with cirrhosis and control subjects had two compartments, with all parameters weight normalized." | 1.30 | Pharmacokinetics and pharmacodynamics of dichloroacetate in patients with cirrhosis. ( Fisher, DM; Shangraw, RE, 1999) |
| "In patients with cirrhosis, septic shock was characterized by severe liver dysfunction, low blood temperature, marked increases in cardiac index and lactic acidemia, and a 100% ICU mortality rate." | 1.28 | Septic shock in patients with cirrhosis: hemodynamic and metabolic characteristics and intensive care unit outcome. ( Assous, M; Hadengue, A; Kirstetter, P; Mamzer, MF; Moreau, R; Sicot, C; Soupison, T; Vanjak, D; Vauquelin, P, 1992) |
| "In inactive liver cirrhosis of alcoholic etiology, the concentrations of lactic and uric acids tended toward reduction, however, they were significantly higher than in the group of patients with virus liver lesions." | 1.27 | [Diagnostic significance of determining the blood content of lactic and uric acids in chronic liver lesions of alcoholic and viral etiologies]. ( Blok, IuE; Dzhalalov, KD; Loginov, AS, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (15.71) | 18.7374 |
| 1990's | 13 (18.57) | 18.2507 |
| 2000's | 11 (15.71) | 29.6817 |
| 2010's | 17 (24.29) | 24.3611 |
| 2020's | 18 (25.71) | 2.80 |
| Authors | Studies |
|---|---|
| Mani, I | 1 |
| Alexopoulos, T | 1 |
| Hadziyannis, E | 1 |
| Tsiriga, A | 1 |
| Vourli, G | 2 |
| Alexopoulou, A | 1 |
| Chen, XF | 1 |
| Maiwall, R | 3 |
| Kumar, A | 3 |
| Pasupuleti, SSR | 1 |
| Hidam, AK | 1 |
| Tevethia, H | 1 |
| Kumar, G | 2 |
| Sahney, A | 1 |
| Mitra, LG | 1 |
| Sarin, SK | 2 |
| Li, X | 1 |
| Gong, M | 1 |
| Fu, S | 1 |
| Zhang, J | 1 |
| Wu, S | 1 |
| Chen, J | 1 |
| Huang, X | 1 |
| Huang, Z | 1 |
| Cao, Y | 1 |
| Calmet, FH | 1 |
| Martin, P | 1 |
| Horvatits, T | 2 |
| Mahmud, N | 2 |
| Serper, M | 2 |
| Seiz, O | 1 |
| Reher, D | 1 |
| Drolz, A | 2 |
| Sarnast, N | 1 |
| Gu, W | 1 |
| Erasmus, HP | 1 |
| Allo, G | 1 |
| Ferstl, P | 1 |
| Wittmann, S | 1 |
| Piecha, F | 1 |
| Groth, S | 1 |
| Zeuzem, S | 1 |
| Schramm, C | 1 |
| Huber, S | 1 |
| Rösch, T | 1 |
| Lohse, AW | 2 |
| Trebicka, J | 1 |
| Ogola, G | 1 |
| Asrani, SK | 4 |
| Kluwe, J | 2 |
| Zheng, L | 1 |
| Lu, Y | 1 |
| Wu, J | 1 |
| Zheng, M | 1 |
| Hu, W | 1 |
| Chen, H | 1 |
| Ma, C | 1 |
| Sun, Q | 1 |
| Yang, M | 1 |
| Wang, H | 1 |
| Peng, Q | 1 |
| Wang, J | 1 |
| Zhang, C | 1 |
| Huang, W | 1 |
| Xie, J | 1 |
| Huang, Y | 2 |
| Zhao, Y | 1 |
| Zhao, M | 1 |
| Zhang, Y | 2 |
| Fu, Z | 1 |
| Jin, T | 1 |
| Song, J | 1 |
| Zhao, C | 1 |
| Wang, M | 1 |
| Chandnani, S | 1 |
| Rathi, P | 1 |
| Udgirkar, SS | 1 |
| Sonthalia, N | 1 |
| Contractor, Q | 1 |
| Jain, S | 1 |
| Sarmast, N | 2 |
| Ogola, GO | 2 |
| Kouznetsova, M | 1 |
| Leise, MD | 1 |
| Bahirwani, R | 1 |
| Tapper, E | 1 |
| Trotter, J | 1 |
| Bajaj, JS | 2 |
| Thacker, LR | 1 |
| Tandon, P | 1 |
| Wong, F | 1 |
| Reddy, KR | 1 |
| O'Leary, JG | 1 |
| Masica, A | 1 |
| Modrykamien, AM | 1 |
| Kamath, PS | 2 |
| Cheng, CY | 1 |
| Kung, CT | 1 |
| Wu, KH | 1 |
| Chen, FC | 1 |
| Cheng, HH | 1 |
| Cheng, FJ | 1 |
| Huang, JB | 1 |
| Su, CM | 1 |
| Kaplan, DE | 1 |
| Taddei, TH | 1 |
| Santos, AA | 1 |
| Afonso, MB | 1 |
| Ramiro, RS | 1 |
| Pires, D | 1 |
| Pimentel, M | 1 |
| Castro, RE | 1 |
| Rodrigues, CMP | 1 |
| Nie, Y | 1 |
| Liu, LX | 1 |
| Chen, T | 1 |
| Zhu, X | 1 |
| Bhakta, D | 1 |
| Patel, M | 1 |
| Ma, TW | 1 |
| Boutté, J | 1 |
| Walter, A | 1 |
| Rudler, M | 1 |
| Olivas, P | 1 |
| Moga, L | 1 |
| Trépo, E | 1 |
| Robic, MA | 1 |
| Ollivier-Hourmand, I | 1 |
| Baiges, A | 1 |
| Sutter, O | 1 |
| Bouzbib, C | 1 |
| Peron, JM | 1 |
| Le Pennec, V | 1 |
| Ganne-Carrié, N | 1 |
| Garcia-Pagán, JC | 1 |
| Mallet, M | 1 |
| Larrue, H | 1 |
| Dao, T | 1 |
| Thabut, D | 1 |
| Hernández-Gea, V | 1 |
| Nault, JC | 1 |
| Bureau, C | 1 |
| Allaire, M | 1 |
| Yang, YY | 1 |
| Hsu, YC | 1 |
| Triantos, C | 1 |
| Kalafateli, M | 1 |
| Aggeletopoulou, I | 1 |
| Mandellou, M | 1 |
| Assimakopoulos, S | 1 |
| Tselekouni, P | 1 |
| Taprantzi, D | 1 |
| Tsiaoussis, G | 1 |
| Anastassiou, ED | 1 |
| Gogos, C | 1 |
| Labropoulou-Karatza, C | 1 |
| Thomopoulos, K | 1 |
| Kok, B | 1 |
| Karvellas, CJ | 2 |
| Abraldes, JG | 2 |
| Jalan, R | 1 |
| Sundaram, V | 1 |
| Gurka, D | 1 |
| Keenan, S | 1 |
| Martinka, G | 1 |
| Bookatz, B | 1 |
| Wood, G | 1 |
| Sun, DQ | 1 |
| Zheng, CF | 1 |
| Lu, FB | 1 |
| Van Poucke, S | 1 |
| Chen, XM | 1 |
| Chen, YP | 1 |
| Zhang, L | 1 |
| Zheng, MH | 1 |
| Rutter, K | 1 |
| Landahl, F | 1 |
| Roedl, K | 1 |
| Meersseman, P | 1 |
| Wilmer, A | 1 |
| Kluge, S | 1 |
| Trauner, M | 1 |
| Fuhrmann, V | 1 |
| Cardoso, FS | 1 |
| Sy, E | 1 |
| Ronco, JJ | 1 |
| Bagulho, L | 1 |
| Mcphail, MJ | 1 |
| Wang, Z | 1 |
| Wang, A | 1 |
| Gong, Z | 1 |
| Biviano, I | 1 |
| Liu, H | 1 |
| Hu, J | 1 |
| Gao, F | 1 |
| Huang, XL | 1 |
| Cai, MX | 1 |
| Lin, MT | 1 |
| Wang, BF | 1 |
| Wu, W | 1 |
| Huang, ZM | 1 |
| Emerson, P | 1 |
| McPeake, J | 1 |
| O'Neill, A | 1 |
| Gilmour, H | 1 |
| Forrest, E | 1 |
| Puxty, A | 1 |
| Kinsella, J | 1 |
| Shaw, M | 1 |
| Cox, IJ | 1 |
| Betrapally, NS | 1 |
| Heuman, DM | 1 |
| Schubert, ML | 1 |
| Ratneswaran, M | 1 |
| Hylemon, PB | 1 |
| White, MB | 1 |
| Daita, K | 1 |
| Noble, NA | 1 |
| Sikaroodi, M | 1 |
| Williams, R | 1 |
| Crossey, MM | 1 |
| Taylor-Robinson, SD | 1 |
| Gillevet, PM | 1 |
| Okubo, H | 1 |
| Nakatsu, Y | 1 |
| Sakoda, H | 1 |
| Kushiyama, A | 1 |
| Fujishiro, M | 1 |
| Fukushima, T | 1 |
| Matsunaga, Y | 1 |
| Ohno, H | 1 |
| Yoneda, M | 1 |
| Kamata, H | 1 |
| Shinjo, T | 1 |
| Iwashita, M | 1 |
| Nishimura, F | 1 |
| Asano, T | 1 |
| Lin, TsT | 1 |
| Gao, DY | 1 |
| Liu, YC | 1 |
| Sung, YC | 1 |
| Wan, D | 1 |
| Liu, JY | 1 |
| Chiang, T | 1 |
| Wang, L | 1 |
| Chen, Y | 2 |
| Mothes, H | 1 |
| Koeppen, J | 1 |
| Bayer, O | 1 |
| Richter, M | 1 |
| Kabisch, B | 1 |
| Schwarzkopf, D | 1 |
| Hein, HA | 1 |
| Zanow, J | 1 |
| Doenst, T | 1 |
| Settmacher, U | 1 |
| Choudhury, A | 1 |
| Kedarisetty, CK | 1 |
| Vashishtha, C | 1 |
| Saini, D | 1 |
| Kumar, S | 1 |
| Sharma, MK | 1 |
| Bhadoria, AS | 1 |
| Joshi, YK | 1 |
| Schreiter, T | 1 |
| Marquitan, G | 1 |
| Darnell, M | 1 |
| Sowa, JP | 1 |
| Bröcker-Preuss, M | 1 |
| Andersson, TB | 1 |
| Baba, HA | 1 |
| Furch, M | 1 |
| Arteel, GE | 1 |
| Mathé, Z | 1 |
| Treckmann, J | 1 |
| Gerken, G | 1 |
| Gieseler, RK | 1 |
| Canbay, A | 1 |
| Choi, SS | 1 |
| Michelotti, GA | 1 |
| Chan, IS | 1 |
| Swiderska-Syn, M | 1 |
| Karaca, GF | 1 |
| Xie, G | 1 |
| Moylan, CA | 1 |
| Garibaldi, F | 1 |
| Premont, R | 1 |
| Suliman, HB | 1 |
| Piantadosi, CA | 1 |
| Diehl, AM | 1 |
| Hong, SH | 1 |
| Park, CS | 1 |
| Jung, HS | 1 |
| Choi, H | 1 |
| Lee, SR | 1 |
| Lee, J | 1 |
| Choi, JH | 1 |
| Shiokawa, H | 1 |
| Akata, T | 1 |
| Yoshino, J | 1 |
| Kandabashi, T | 1 |
| Kanna, T | 1 |
| Takahashi, S | 1 |
| Strauss, GI | 1 |
| Møller, K | 1 |
| Larsen, FS | 1 |
| Kondrup, J | 2 |
| Knudsen, GM | 1 |
| Ruan, P | 1 |
| Gong, ZJ | 1 |
| Zhang, QR | 1 |
| Shiraishi, K | 1 |
| Motegi, S | 1 |
| Nagaoka, R | 1 |
| Ogasawara, F | 1 |
| Saito, T | 1 |
| Watanabe, M | 1 |
| Matsuzaki, S | 1 |
| Shangraw, RE | 2 |
| Funk, GC | 1 |
| Doberer, D | 1 |
| Kneidinger, N | 1 |
| Lindner, G | 1 |
| Holzinger, U | 1 |
| Schneeweiss, B | 1 |
| Rojkind, M | 1 |
| Kershenobich, D | 1 |
| Salerno, F | 2 |
| Abbiati, R | 2 |
| Fici, F | 3 |
| Lorenzini, MC | 1 |
| Conti, M | 1 |
| Katsuta, Y | 1 |
| Alberti, KG | 1 |
| Johnston, DG | 1 |
| Piniewska-Hulas, M | 1 |
| Whittaker, J | 1 |
| Egberts, EH | 1 |
| Rittershofer, H | 1 |
| Müller, PH | 1 |
| Schmülling, R | 1 |
| Prestele, H | 1 |
| Horbach, L | 1 |
| Malchow, H | 1 |
| Belvisi, A | 1 |
| Matergi, M | 1 |
| Petrides, AS | 3 |
| Vogt, C | 2 |
| Schulze-Berge, D | 2 |
| Matthews, D | 1 |
| Strohmeyer, G | 2 |
| Nagamine, T | 1 |
| Saito, S | 1 |
| Yamada, S | 1 |
| Arai, T | 1 |
| Takehara, K | 1 |
| Fukui, T | 1 |
| Matthews, DE | 2 |
| Sewell, AC | 2 |
| Sperl, W | 2 |
| Herwig, J | 2 |
| Böhles, HJ | 2 |
| Esser, U | 1 |
| Iida, T | 1 |
| Shijo, H | 1 |
| Yokoyama, M | 1 |
| Ota, K | 1 |
| Kakumitsu, S | 1 |
| Kim, T | 1 |
| Akiyoshi, N | 1 |
| Okumura, M | 1 |
| Fisher, DM | 1 |
| Orii, R | 2 |
| Sugawara, Y | 2 |
| Hayashida, M | 2 |
| Yamada, Y | 2 |
| Chang, K | 1 |
| Takayama, T | 2 |
| Makuuchi, M | 2 |
| Hanaoka, K | 2 |
| Clemmesen, JO | 1 |
| Høy, CE | 1 |
| Ott, P | 1 |
| Uchida, K | 1 |
| Kiwanuka, E | 1 |
| Barazzoni, R | 1 |
| Tessari, P | 1 |
| Koelzow, H | 1 |
| Gedney, JA | 1 |
| Baumann, J | 1 |
| Snook, NJ | 1 |
| Bellamy, MC | 1 |
| Moreau, R | 1 |
| Hadengue, A | 1 |
| Soupison, T | 1 |
| Kirstetter, P | 1 |
| Mamzer, MF | 1 |
| Vanjak, D | 1 |
| Vauquelin, P | 1 |
| Assous, M | 1 |
| Sicot, C | 1 |
| Green, JH | 1 |
| Bramley, PN | 1 |
| Losowsky, MS | 1 |
| Mizobuchi, N | 1 |
| Kuwao, F | 1 |
| Takeda, I | 1 |
| Takemura, T | 1 |
| Morita, S | 1 |
| Horimi, T | 1 |
| Takahashi, I | 1 |
| Vicens, J | 1 |
| Obrador, A | 1 |
| Gayá, J | 1 |
| Cortés, R | 1 |
| Höring, E | 1 |
| Kubin, S | 1 |
| von Gaisberg, U | 1 |
| Hattori, T | 1 |
| Hotta, N | 1 |
| Ohara, K | 1 |
| Shinoda, H | 1 |
| Kunieda, T | 1 |
| Nomura, T | 1 |
| Kakuta, H | 1 |
| Tamagawa, T | 1 |
| Sakamoto, N | 1 |
| Almenoff, PL | 1 |
| Leavy, J | 1 |
| Weil, MH | 1 |
| Goldberg, NB | 1 |
| Vega, D | 1 |
| Rackow, EC | 1 |
| Lao, B | 1 |
| Szczepanik, Z | 1 |
| Bartosiewicz, W | 1 |
| Czyzyk, A | 1 |
| Loginov, AS | 1 |
| Dzhalalov, KD | 1 |
| Blok, IuE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of Colloid (20% Albumin) Versus Crystalloid (Plasmalyte) for Fluid Resuscitation in Cirrhotics With Sepsis Induced Hypotension.[NCT02721238] | 100 participants (Actual) | Interventional | 2016-12-01 | Completed | |||
| Role of Blood Lactate Level in Prediction of Outcome of Cirrhotic Patients at The Intensive Care Unit[NCT06121908] | 50 participants (Anticipated) | Observational | 2023-11-15 | Not yet recruiting | |||
| [NCT01458990] | 60 participants (Actual) | Interventional | 2011-10-31 | Completed | |||
| A Prospective Open Label Randomized Non Inferiority Trial to Compare the Efficacy and Safety of Monotherapy With Noradrenaline and Terlipressin in Patients of Cirrhosis With Septic Shock Admitted to Intensive Care Unit.[NCT01836224] | 84 participants (Actual) | Interventional | 2012-10-31 | Completed | |||
| To Compare 20% Albumin vs. Balanced Salt Solution as Resuscitation Fluid and Identify Fluid Responsiveness Criteria in Critically Ill Patients With Cirrhosis With Sepsis Induced Hypotension; a Prospective Randomized Controlled Trial.[NCT05441878] | Phase 4 | 150 participants (Anticipated) | Interventional | 2020-08-15 | Recruiting | ||
| To Compare the Effectiveness of Various Methods of Estimating Volume Resuscitation in Patients With Cirrhosis With Sepsis Induced Hypotension[NCT05059795] | 75 participants (Anticipated) | Observational | 2020-02-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Analysis at baseline will be compared to that at 2 weeks. This will be specifically, changes in those with PPI withdrawal compared to those with PPI initiation (NCT01458990)
Timeframe: 2 weeks
| Intervention | Participants (Count of Participants) |
|---|---|
| PPI Initiation | 0 |
| PPI Withdrawal | 0 |
Analysis at baseline will be compared to that at 2 weeks using Multitagged sequencing. Number of patients with overgrowth of oral microbiota in their stool after PPI therapy withdrawal or initiation were specifically analyzed. (NCT01458990)
Timeframe: 2 weeks
| Intervention | Participants (Count of Participants) |
|---|---|
| PPI Inititation | 45 |
| PPI Withdrawal | 15 |
3 reviews available for lactic acid and Liver Cirrhosis
| Article | Year |
|---|---|
Metabolic issues in liver transplantation.
Topics: Acid-Base Equilibrium; Calcium; Citric Acid; Electrolytes; Glucose; Hormones; Humans; Lactic Acid; L | 2006 |
Diagnostic procedures for liver fibrosis.
Topics: Animals; Glucosyltransferases; Humans; Lactates; Lactic Acid; Liver; Liver Cirrhosis; Liver Cirrhosi | 1983 |
Disturbances of metabolic homeostasis is liver disease.
Topics: Fasting; Glucagon; Gluconeogenesis; Glucose Tolerance Test; Growth Hormone; Homeostasis; Humans; Hyd | 1981 |
8 trials available for lactic acid and Liver Cirrhosis
| Article | Year |
|---|---|
A randomized-controlled trial comparing 20% albumin to plasmalyte in patients with cirrhosis and sepsis-induced hypotension [ALPS trial].
Topics: Albumins; Critical Illness; Electrolytes; Fluid Therapy; Humans; Hypotension, Controlled; Lactic Aci | 2022 |
Systems biology analysis of omeprazole therapy in cirrhosis demonstrates significant shifts in gut microbiota composition and function.
Topics: Arginine; Biomarkers; Case-Control Studies; Feces; Female; Gastrins; Hippurates; Humans; Intestines; | 2014 |
A randomized trial comparing terlipressin and noradrenaline in patients with cirrhosis and septic shock.
Topics: Adult; Female; Hemodynamics; Humans; India; Kaplan-Meier Estimate; Lactic Acid; Liver Cirrhosis; Log | 2017 |
A comparison of intra-operative blood loss and acid-base balance between vasopressor and inotrope strategy during living donor liver transplantation: a randomised, controlled study.
Topics: Acid-Base Equilibrium; Anesthesia; Blood Loss, Surgical; Cardiotonic Agents; Dobutamine; Dopamine; F | 2012 |
Effect of pyridoxine-2-oxoglutarate administration in patients with advanced cirrhosis: control of ammonia pyruvate and lactate high plasma concentrations.
Topics: Amino Acids; Ammonia; Blood Glucose; Clinical Trials as Topic; Double-Blind Method; Humans; Lactates | 1982 |
Effects of amrinone on ischaemia-reperfusion injury in cirrhotic patients undergoing hepatectomy: a comparative study with prostaglandin E1.
Topics: Aged; Alprostadil; Amrinone; Analysis of Variance; Female; Hepatectomy; Humans; Indocyanine Green; L | 2000 |
Lactate is correlated with the indocyanine green elimination rate in liver resection for cirrhotic patients.
Topics: Adult; Aged; Aged, 80 and over; Carbon Dioxide; Coloring Agents; Female; Hemodynamics; Humans; Indoc | 2001 |
The effect of methylene blue on the hemodynamic changes during ischemia reperfusion injury in orthotopic liver transplantation.
Topics: Blood Pressure; Cardiac Output; Central Venous Pressure; Cyclic GMP; Enzyme Inhibitors; Female; Guan | 2002 |
59 other studies available for lactic acid and Liver Cirrhosis
| Article | Year |
|---|---|
An exploratory study of ascitic fluid lactate as prognostic factor of mortality in cirrhotic patients with spontaneous bacterial peritonitis.
Topics: Acute-On-Chronic Liver Failure; Ascitic Fluid; End Stage Liver Disease; Humans; Lactic Acid; Liver C | 2021 |
Prognostic Role of MELD-Lactate in Cirrhotic Patients' Short- and Long-Term Prognosis, Stratified by Causes of Cirrhosis.
Topics: Critical Illness; End Stage Liver Disease; Humans; Lactic Acid; Liver Cirrhosis; Prognosis; Retrospe | 2022 |
Establishment of MELD-lactate clearance scoring system in predicting death risk of critically ill cirrhotic patients.
Topics: Critical Illness; End Stage Liver Disease; Humans; Lactic Acid; Liver Cirrhosis; Prognosis; Retrospe | 2022 |
Activated Hepatic Stellate Cells Promote the M1 to M2 Macrophage Transformation and Liver Fibrosis by Elevating the Histone Acetylation Level.
Topics: Acetylation; Animals; Hepatic Stellate Cells; Histones; Humans; Lactic Acid; Liver; Liver Cirrhosis; | 2022 |
Acid Test: MELD-Lactate Enhances Prediction in Patients with Variceal Hemorrhage.
Topics: Esophageal and Gastric Varices; Gastrointestinal Hemorrhage; Humans; Lactic Acid; Liver Cirrhosis; P | 2023 |
MELD-Lactate Predicts Poor Outcome in Variceal Bleeding in Cirrhosis.
Topics: End Stage Liver Disease; Esophageal and Gastric Varices; Gastrointestinal Hemorrhage; Humans; Lactic | 2023 |
Development and validation of a prognostic nomogram model for ICU patients with alcohol-associated cirrhosis.
Topics: Critical Care; Humans; Intensive Care Units; Lactic Acid; Liver Cirrhosis; Liver Cirrhosis, Alcoholi | 2023 |
Identification of indications for albumin administration in septic patients with liver cirrhosis.
Topics: Humans; Lactic Acid; Liver Cirrhosis; Serum Albumin; Shock, Septic; Vasoconstrictor Agents | 2023 |
Bile acids metabolism involved in the beneficial effects of Danggui Shaoyao San via gut microbiota in the treatment of CCl
Topics: Animals; Bile Acids and Salts; Gastrointestinal Microbiome; Lactic Acid; Liver Cirrhosis; Rats; RNA, | 2024 |
CLINICAL UTILITY OF RISK SCORES IN VARICEAL BLEEDING.
Topics: Adult; Blood Transfusion; End Stage Liver Disease; Endoscopy; Esophageal and Gastric Varices; Female | 2019 |
Model for End-Stage Liver Disease-Lactate and Prediction of Inpatient Mortality in Patients With Chronic Liver Disease.
Topics: Aged; Clinical Decision-Making; Decision Support Techniques; End Stage Liver Disease; Female; Hospit | 2020 |
Liver cirrhosis affects serum lactate level measurement while assessing disease severity in patients with sepsis.
Topics: Humans; Lactic Acid; Liver Cirrhosis; Prognosis; Retrospective Studies; ROC Curve; Sepsis; Severity | 2021 |
The Predictive Role of Model for End-Stage Liver Disease-Lactate and Lactate Clearance for In-Hospital Mortality Among a National Cirrhosis Cohort.
Topics: Cohort Studies; End Stage Liver Disease; Hospital Mortality; Humans; Lactic Acid; Liver Cirrhosis; L | 2021 |
Host miRNA-21 promotes liver dysfunction by targeting small intestinal
Topics: Animals; Cholestasis; Dysbiosis; Female; Gastrointestinal Microbiome; Lactic Acid; Lactobacillus; Li | 2020 |
Serum lactate level predicts 6-months mortality in patients with hepatitis B virus-related decompensated cirrhosis: a retrospective study.
Topics: Aged; Ascites; Carcinoma, Hepatocellular; Female; gamma-Glutamyltransferase; Hepatitis B; Hepatitis | 2021 |
Model for End-Stage Liver Disease Lactate Score and Prediction of Inpatient Mortality in Critically Ill Patients With Cirrhosis.
Topics: Critical Illness; End Stage Liver Disease; Humans; Inpatients; Intensive Care Units; Lactic Acid; Li | 2021 |
Combination of Model for End-Stage Liver Disease and Lactate Predicts Death in Patients Treated With Salvage Transjugular Intrahepatic Portosystemic Shunt for Refractory Variceal Bleeding.
Topics: Biomarkers; End Stage Liver Disease; Esophageal and Gastric Varices; Female; France; Gastrointestina | 2021 |
Effectiveness of sepsis bundle application and outcomes predictors to cirrhotic patients with septic shock.
Topics: Adult; Area Under Curve; Case-Control Studies; Emergency Service, Hospital; Humans; Lactic Acid; Liv | 2021 |
Lactate serum concentrations during treatment with nucleos(t)ide analogues in hepatitis B with or without cirrhosis.
Topics: Acidosis, Lactic; Adenine; Adult; Aged; Aged, 80 and over; Antiviral Agents; Biomarkers; Drug Therap | 2017 |
The impact of obesity in cirrhotic patients with septic shock: A retrospective cohort study.
Topics: Aged; Body Mass Index; Canada; Comorbidity; Critical Illness; Databases, Factual; Female; Hospital M | 2018 |
Serum lactate level accurately predicts mortality in critically ill patients with cirrhosis with acute kidney injury.
Topics: Acute Kidney Injury; Aged; Biomarkers; Critical Illness; Databases, Factual; Female; Hospital Mortal | 2018 |
Lactate Improves Prediction of Short-Term Mortality in Critically Ill Patients With Cirrhosis: A Multinational Study.
Topics: Acute-On-Chronic Liver Failure; Aged; Critical Illness; Female; Humans; Internationality; Lactic Aci | 2019 |
Lactate and number of organ failures predict intensive care unit mortality in patients with acute-on-chronic liver failure.
Topics: Acute-On-Chronic Liver Failure; Calibration; Canada; Decision Support Techniques; Female; Hospital M | 2019 |
Plasma claudin-3 is associated with tumor necrosis factor-alpha-induced intestinal endotoxemia in liver disease.
Topics: Acute-On-Chronic Liver Failure; Adult; Aged; Analysis of Variance; Biomarkers; Carcinoma, Hepatocell | 2019 |
Prognostic value of serum lactate kinetics in critically ill patients with cirrhosis and acute-on-chronic liver failure: a multicenter study.
Topics: Acute-On-Chronic Liver Failure; Aged; Area Under Curve; Cohort Studies; Critical Illness; Female; Hu | 2019 |
The utility of scoring systems in critically ill cirrhotic patients admitted to a general intensive care unit.
Topics: Acute Kidney Injury; Adult; Aged; Analysis of Variance; Area Under Curve; Critical Illness; Female; | 2014 |
Mosapride citrate improves nonalcoholic steatohepatitis with increased fecal lactic acid bacteria and plasma glucagon-like peptide-1 level in a rodent model.
Topics: Animals; Benzamides; Choline Deficiency; Feces; Gastrointestinal Tract; Glucagon-Like Peptide 1; Inf | 2015 |
Development and characterization of sorafenib-loaded PLGA nanoparticles for the systemic treatment of liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Drug Carriers; Human Umbilical Vein Endothelial Cells; Lactic Acid; L | 2016 |
Acute mesenteric ischemia following cardiovascular surgery--A nested case-control study.
Topics: Aged; Cardiac Surgical Procedures; Case-Control Studies; Emergencies; Epinephrine; Female; Hospital | 2016 |
An ex vivo perfusion system emulating in vivo conditions in noncirrhotic and cirrhotic human liver.
Topics: Adult; Aged; Albumins; Apoptosis; Bile Acids and Salts; Biomarkers; Cytochrome P-450 Enzyme System; | 2012 |
Hedgehog controls hepatic stellate cell fate by regulating metabolism.
Topics: Actins; Animals; Bile Ducts; Carbon Tetrachloride; Cell Transdifferentiation; Cells, Cultured; Gene | 2012 |
[Changes in acid-base balance and blood lactate levels during radio frequency ablation conducted for the treatment of hepatocellular carcinomata in patients with liver cirrhosis].
Topics: Acid-Base Equilibrium; Aged; Carcinoma, Hepatocellular; Catheter Ablation; Female; Hepatectomy; Huma | 2002 |
Cerebral glucose and oxygen metabolism in patients with fulminant hepatic failure.
Topics: Acetoacetates; Brain; Humans; Lactic Acid; Liver Cirrhosis; Liver Failure; Oxygen; Oxygen Consumptio | 2003 |
Changes of plasma D(-)-lactate, diamine oxidase and endotoxin in patients with liver cirrhosis.
Topics: Adolescent; Adult; Amine Oxidase (Copper-Containing); Analysis of Variance; Biomarkers; Case-Control | 2004 |
Study of energy metabolism of skeletal muscles in alcoholic liver disease--expired gas analysis during exercise.
Topics: Adult; Aerobiosis; Anaerobic Threshold; Diabetes Complications; Diabetes Mellitus; Energy Metabolism | 2005 |
Acid-base disturbances in critically ill patients with cirrhosis.
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Adult; APACHE; Critical Illness; Female; Hospital Mortality | 2007 |
Effect of pyridoxine alpha-ketoglutarate (PAK) on ammonia and pyruvic and lactic acid blood levels in patients with cirrhosis.
Topics: Aged; Amino Acids; Ammonia; Blood Glucose; Double-Blind Method; Drug Evaluation; Female; Humans; Lac | 1983 |
[Acid-base disturbance in patients with compensated liver cirrhosis and chronic hepatitis (author's transl)].
Topics: Acid-Base Imbalance; Adult; Carbon Dioxide; Chronic Disease; Female; Hepatitis; Humans; Lactates; La | 1981 |
[Carbohydrate infusion in internal diseases. A comparative study in metabolically healthy, liver diseased and diabetic patients. VI. Infusions of a glucose/xylitol mixture (1:1 ratio) over a 48-hour period].
Topics: Blood Glucose; Diabetes Mellitus; Fatty Acids, Nonesterified; Glucose; Glucose Solution, Hypertonic; | 1982 |
Treatment of hyperlactacidemia in cirrhotic patients with pyridoxine-alpha-ketoglutarate (PAK).
Topics: Acidosis; Adult; Aged; Ammonia; Double-Blind Method; Female; Humans; Lactates; Lactic Acid; Liver Ci | 1982 |
Pathogenesis of glucose intolerance and diabetes mellitus in cirrhosis.
Topics: Adult; Aged; Blood Glucose; C-Peptide; Diabetes Mellitus; Female; Glucose; Glucose Clamp Technique; | 1994 |
Biotinidase activity in patients with liver disease.
Topics: 3-Hydroxybutyric Acid; Acute Disease; Adult; Aged; Amidohydrolases; Biotin; Biotinidase; Carcinoma, | 1993 |
Glucose resistance contributes to diabetes mellitus in cirrhosis.
Topics: Adult; Aged; Blood Glucose; C-Peptide; Diabetes Complications; Diabetes Mellitus; Drug Resistance; F | 1993 |
Cirrhosis in a child with deficiency of mitochondrial respiratory-chain succinate-cytochrome c-oxidoreductase.
Topics: Electron Transport Complex II; Electron Transport Complex III; Epilepsy, Tonic-Clonic; Fatal Outcome | 1997 |
Effect of moderate exercise on insulin sensitivity and substrate metabolism during post-exercise recovery in cirrhosis.
Topics: Adult; Exercise; Female; Glucagon; Glucose; Humans; Insulin; Insulin Resistance; Lactic Acid; Liver | 1997 |
Mitochondrial respiratory chain succinate-cytochrome-c oxidoreductase deficiency and hepatic cirrhosis.
Topics: Electron Transport; Fatal Outcome; Humans; Infant; Lactic Acid; Liver; Liver Cirrhosis; Male; Mitoch | 1997 |
Effects of endoscopic variceal ligation on oxygen transport and the arterial lactate levels in patients with cirrhosis.
Topics: Aged; Analysis of Variance; Arteries; Catheterization, Swan-Ganz; Echocardiography, Doppler; Endosco | 1998 |
Pharmacokinetics and pharmacodynamics of dichloroacetate in patients with cirrhosis.
Topics: Adult; Blood Glucose; Case-Control Studies; Dichloroacetic Acid; Female; Humans; Hypoglycemia; Lacti | 1999 |
Splanchnic metabolism of fuel substrates in acute liver failure.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acute Kidney Injury; Adult; Blood Glucose; Female; Hepatic Enc | 2000 |
Glucose kinetics and splanchnic uptake following mixed meal ingestion in cirrhotic-diabetic subjects.
Topics: Adult; Blood Glucose; Diabetes Complications; Diabetes Mellitus; Dietary Carbohydrates; Fatty Acids, | 2001 |
Septic shock in patients with cirrhosis: hemodynamic and metabolic characteristics and intensive care unit outcome.
Topics: Acid-Base Equilibrium; Chi-Square Distribution; Critical Care; Hemodynamics; Humans; Lactates; Lacti | 1992 |
Septic shock in patients with cirrhosis: hemodynamic and metabolic characteristics and intensive care unit outcome.
Topics: Acid-Base Equilibrium; Chi-Square Distribution; Critical Care; Hemodynamics; Humans; Lactates; Lacti | 1992 |
Septic shock in patients with cirrhosis: hemodynamic and metabolic characteristics and intensive care unit outcome.
Topics: Acid-Base Equilibrium; Chi-Square Distribution; Critical Care; Hemodynamics; Humans; Lactates; Lacti | 1992 |
Septic shock in patients with cirrhosis: hemodynamic and metabolic characteristics and intensive care unit outcome.
Topics: Acid-Base Equilibrium; Chi-Square Distribution; Critical Care; Hemodynamics; Humans; Lactates; Lacti | 1992 |
Are patients with primary biliary cirrhosis hypermetabolic? A comparison between patients before and after liver transplantation and controls.
Topics: Blood Glucose; Dietary Fats; Eating; Energy Metabolism; Fasting; Fatty Acids, Nonesterified; Female; | 1991 |
[Changes in ketone body ratio and levels of pyruvate and lactate in arterial blood of patients with hepatocellular carcinoma after transcatheter arterial embolization].
Topics: Carcinoma, Hepatocellular; Embolization, Therapeutic; Humans; Ketones; Lactates; Lactic Acid; Liver; | 1990 |
[Spontaneous bacterial peritonitis in the cirrhotic patient. A study by discriminant analysis].
Topics: Ascites; Ascitic Fluid; Bacterial Infections; Discriminant Analysis; Glucose; Humans; L-Lactate Dehy | 1990 |
[Spontaneous bacterial peritonitis: studies of the incidence and clinical and laboratory chemical parameters].
Topics: Ascitic Fluid; Bacterial Infections; Bacteriological Techniques; Blood Glucose; Blood Proteins; Chol | 1990 |
Pancreatic alpha- and beta-cell function and metabolic changes during oral L-alanine and glucose administration: comparative studies between normal, diabetic and cirrhotic subjects.
Topics: Administration, Oral; Adult; Alanine; Blood Glucose; Diabetes Mellitus; Female; Glucose; Glucose Tol | 1989 |
Prolongation of the half-life of lactate after maximal exercise in patients with hepatic dysfunction.
Topics: Half-Life; Humans; Lactates; Lactic Acid; Liver Cirrhosis; Male; Middle Aged; Physical Exertion | 1989 |
[Post-fructose increase in the blood level of lactic acid in various pathologic conditions].
Topics: Aged; Bronchitis; Chronic Disease; Diabetes Mellitus; Female; Fructose; Humans; Infusions, Intraveno | 1987 |
[Diagnostic significance of determining the blood content of lactic and uric acids in chronic liver lesions of alcoholic and viral etiologies].
Topics: Adult; Chronic Disease; Female; Hepatitis, Alcoholic; Hepatitis, Chronic; Humans; Lactates; Lactic A | 1985 |