lactic acid has been researched along with Leukomalacia, Periventricular in 4 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Leukomalacia, Periventricular: Degeneration of white matter adjacent to the CEREBRAL VENTRICLES following cerebral hypoxia or BRAIN ISCHEMIA in neonates. The condition primarily affects white matter in the perfusion zone between superficial and deep branches of the MIDDLE CEREBRAL ARTERY. Clinical manifestations include VISION DISORDERS; CEREBRAL PALSY; PARAPLEGIA; SEIZURES; and cognitive disorders. (From Adams et al., Principles of Neurology, 6th ed, p1021; Joynt, Clinical Neurology, 1997, Ch4, pp30-1)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pyruvate dehydrogenase (PDH) deficiency is a major cause of primary lactic acidosis and neurological dysfunction in infancy and early childhood." | 3.78 | Unilateral periventricular leukomalacia in association with pyruvate dehydrogenase deficiency. ( Connolly, DJ; Mordekar, SR; Sharma, R; Sharrard, MJ, 2012) |
| "Preoperative MRI examinations showed periventricular leukomalacia (PVL) in 4 patients (16%) and infarct in 2 subjects (8%)." | 2.70 | An MRI study of neurological injury before and after congenital heart surgery. ( Chiavacci, RM; Clancy, RR; Galli, KK; Gaynor, JW; Kurth, CD; Mahle, WT; Montenegro, LM; Nicolson, SC; Spray, TL; Tavani, F; Wernovsky, G; Zimmerman, RA, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nadeem, M | 1 |
| Clarke, A | 1 |
| Dempsey, EM | 1 |
| Sharma, R | 1 |
| Sharrard, MJ | 1 |
| Connolly, DJ | 1 |
| Mordekar, SR | 1 |
| Mahle, WT | 1 |
| Tavani, F | 1 |
| Zimmerman, RA | 1 |
| Nicolson, SC | 1 |
| Galli, KK | 1 |
| Gaynor, JW | 1 |
| Clancy, RR | 1 |
| Montenegro, LM | 1 |
| Spray, TL | 1 |
| Chiavacci, RM | 1 |
| Wernovsky, G | 1 |
| Kurth, CD | 1 |
| Kidokoro, H | 1 |
| Shimizu, M | 1 |
| Kimoto, H | 1 |
| Okumura, A | 1 |
| Hayakawa, M | 1 |
| Watanabe, K | 1 |
| Ohno, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Cerebral Anatomy, Hemodynamics and Metabolism In Single Ventricles: Relationship to Neurodevelopment[NCT02919956] | 119 participants (Actual) | Observational | 2016-04-30 | Active, not recruiting | |||
| International Study of Cerebral Oxygenation and Electrical Activity During Major Neonatal Surgery[NCT05673499] | 900 participants (Anticipated) | Observational | 2022-08-12 | Recruiting | |||
| Autologous Cord Blood Cells for Patients With HLHS: Phase I Study of Feasibility and Safety[NCT01445041] | Phase 1 | 7 participants (Actual) | Interventional | 2011-09-01 | Terminated (stopped due to Funding Period Ended) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for lactic acid and Leukomalacia, Periventricular
| Article | Year |
|---|---|
An MRI study of neurological injury before and after congenital heart surgery.
Topics: Brain; Brain Chemistry; Cardiopulmonary Bypass; Cerebral Infarction; Cerebrovascular Disorders; Coho | 2002 |
An MRI study of neurological injury before and after congenital heart surgery.
Topics: Brain; Brain Chemistry; Cardiopulmonary Bypass; Cerebral Infarction; Cerebrovascular Disorders; Coho | 2002 |
An MRI study of neurological injury before and after congenital heart surgery.
Topics: Brain; Brain Chemistry; Cardiopulmonary Bypass; Cerebral Infarction; Cerebrovascular Disorders; Coho | 2002 |
An MRI study of neurological injury before and after congenital heart surgery.
Topics: Brain; Brain Chemistry; Cardiopulmonary Bypass; Cerebral Infarction; Cerebrovascular Disorders; Coho | 2002 |
An MRI study of neurological injury before and after congenital heart surgery.
Topics: Brain; Brain Chemistry; Cardiopulmonary Bypass; Cerebral Infarction; Cerebrovascular Disorders; Coho | 2002 |
An MRI study of neurological injury before and after congenital heart surgery.
Topics: Brain; Brain Chemistry; Cardiopulmonary Bypass; Cerebral Infarction; Cerebrovascular Disorders; Coho | 2002 |
An MRI study of neurological injury before and after congenital heart surgery.
Topics: Brain; Brain Chemistry; Cardiopulmonary Bypass; Cerebral Infarction; Cerebrovascular Disorders; Coho | 2002 |
An MRI study of neurological injury before and after congenital heart surgery.
Topics: Brain; Brain Chemistry; Cardiopulmonary Bypass; Cerebral Infarction; Cerebrovascular Disorders; Coho | 2002 |
An MRI study of neurological injury before and after congenital heart surgery.
Topics: Brain; Brain Chemistry; Cardiopulmonary Bypass; Cerebral Infarction; Cerebrovascular Disorders; Coho | 2002 |
3 other studies available for lactic acid and Leukomalacia, Periventricular
| Article | Year |
|---|---|
Day 1 serum lactate values in preterm infants less than 32 weeks gestation.
Topics: Acid-Base Imbalance; Biomarkers; Humans; Infant, Newborn; Infant, Premature; Infant, Very Low Birth | 2010 |
Unilateral periventricular leukomalacia in association with pyruvate dehydrogenase deficiency.
Topics: Acidosis, Lactic; Alleles; Cerebral Ventricles; Developmental Disabilities; Diagnosis, Differential; | 2012 |
Relationship between serum lactate level and periventricular leukomalacia.
Topics: Case-Control Studies; Female; Gestational Age; Humans; Infant, Newborn; Infant, Premature; Infant, P | 2007 |