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lactic acid and Leukodystrophy, Metachromatic

lactic acid has been researched along with Leukodystrophy, Metachromatic in 2 studies

Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.

Leukodystrophy, Metachromatic: An autosomal recessive metabolic disease caused by a deficiency of CEREBROSIDE-SULFATASE leading to intralysosomal accumulation of cerebroside sulfate (SULFOGLYCOSPHINGOLIPIDS) in the nervous system and other organs. Pathological features include diffuse demyelination, and metachromatically-staining granules in many cell types such as the GLIAL CELLS. There are several allelic and nonallelic forms with a variety of neurological symptoms.

Research Excerpts

ExcerptRelevanceReference
"The lysosomal storage disorder (LSD) metachromatic leukodystrophy (MLD) is caused by a deficiency of the soluble, lysosomal hydrolase arylsulfatase A (ASA)."1.46Potential of surfactant-coated nanoparticles to improve brain delivery of arylsulfatase A. ( Gelperina, S; Gieselmann, V; Kreuter, J; Maksimenko, O; Matzner, U; Mühlstein, A; Schuster, T; Shipulo, E; Yaghootfam, C, 2017)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (50.00)18.2507
2000's0 (0.00)29.6817
2010's1 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Schuster, T1
Mühlstein, A1
Yaghootfam, C1
Maksimenko, O1
Shipulo, E1
Gelperina, S1
Kreuter, J1
Gieselmann, V1
Matzner, U1
Kruse, B1
Hanefeld, F1
Christen, HJ1
Bruhn, H1
Michaelis, T1
Hänicke, W1
Frahm, J1

Other Studies

2 other studies available for lactic acid and Leukodystrophy, Metachromatic

ArticleYear
Potential of surfactant-coated nanoparticles to improve brain delivery of arylsulfatase A.
    Journal of controlled release : official journal of the Controlled Release Society, 2017, 05-10, Volume: 253

    Topics: Animals; Avidin; Biotinylation; Brain; Cerebroside-Sulfatase; Female; Lactic Acid; Leukodystrophy, M

2017
Alterations of brain metabolites in metachromatic leukodystrophy as detected by localized proton magnetic resonance spectroscopy in vivo.
    Journal of neurology, 1993, Volume: 241, Issue:2

    Topics: Adolescent; Aspartic Acid; Bone Marrow Transplantation; Brain; Brain Chemistry; Child; Child, Presch

1993