Page last updated: 2024-10-17

lactic acid and Leukemia, Myeloid, Acute

lactic acid has been researched along with Leukemia, Myeloid, Acute in 14 studies

Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.

Leukemia, Myeloid, Acute: Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.

Research Excerpts

ExcerptRelevanceReference
"In models of brain cancer and AML, tumor growth was potently inhibited in vivo following IACS-010759 treatment at well-tolerated doses."1.48An inhibitor of oxidative phosphorylation exploits cancer vulnerability. ( Ackroyd, J; Agip, AA; Al-Atrash, G; Asara, J; Bandi, M; Bardenhagen, J; Bristow, C; Carrillo, CC; Carroll, C; Chang, E; Ciurea, S; Cross, JB; Czako, B; Daver, N; de Groot, JF; Deem, A; DePinho, RA; Di Francesco, ME; Do, MG; Dong, JW; Draetta, GF; Feng, N; Gao, G; Gay, J; Gera, S; Giuliani, V; Greer, J; Han, J; Han, L; Heffernan, TP; Henry, VK; Hirst, J; Huang, S; Jiang, Y; Jones, P; Kang, Z; Khor, T; Konoplev, S; Konopleva, M; Lin, YH; Liu, G; Lodi, A; Lofton, T; Ma, H; Mahendra, M; Marszalek, JR; Matre, P; McAfoos, T; Molina, JR; Morlacchi, P; Muller, F; Mullinax, R; Peoples, M; Petrocchi, A; Protopopova, M; Rodriguez-Canale, J; Serreli, R; Shi, T; Smith, M; Sun, Y; Tabe, Y; Theroff, J; Tiziani, S; Toniatti, C; Xu, Q; Zhang, Q, 2018)
"Culturing of acute myeloid leukemia (AML) KG1a cells in FN-coated PU/PLLA 60:40 shows increased cell adhesion and cell adhesion-mediated drug resistance to the drugs cytarabine and daunorubicin without changing the original CD34(+)/CD38(-)/CD33(-) phenotype for 168 hours compared to fibronectin tissue culture plate systems."1.42Development and molecular characterization of polymeric micro-nanofibrous scaffold of a defined 3-D niche for in vitro chemosensitivity analysis against acute myeloid leukemia cells. ( Koyakutty, M; Menon, D; Menon, KN; Mony, U; Nair, MS; Nair, SV; Pavithran, K; Sidharthan, N, 2015)
"Neutropenia is a major risk factor for developing a serious infection."1.34Predictive factors of septic shock and mortality in neutropenic patients. ( Balkis, M; Hela, BA; Karima, K; Lamia, A; Mohamed, Z; Raihane, B; Ramzi, J; Yosr, B; Zaher, B, 2007)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19901 (7.14)18.7374
1990's0 (0.00)18.2507
2000's1 (7.14)29.6817
2010's6 (42.86)24.3611
2020's6 (42.86)2.80

Authors

AuthorsStudies
Man, CH1
Mercier, FE1
Liu, N1
Dong, W1
Stephanopoulos, G1
Jiang, L1
Jung, Y1
Lin, CP1
Leung, AYH1
Scadden, DT1
Erdem, A1
Marin, S1
Pereira-Martins, DA1
Geugien, M1
Cunningham, A1
Pruis, MG1
Weinhäuser, I1
Gerding, A1
Bakker, BM1
Wierenga, ATJ1
Rego, EM1
Huls, G1
Cascante, M1
Schuringa, JJ1
Alshamleh, I1
Krause, N1
Richter, C1
Kurrle, N1
Serve, H1
Günther, UL1
Schwalbe, H1
Puente-Moncada, N1
Turos-Cabal, M1
Sánchez-Sánchez, AM1
Antolín, I1
Herrera, F1
Rodriguez-Blanco, J1
Duarte-Olivenza, C1
Rodriguez, C1
Martín, V1
Hampton, T1
Fenu, EM1
O'Neill, SS1
Insuasti-Beltran, G1
Pettenati, MJ1
Giffen, M1
Harrison, WT1
Molina, JR1
Sun, Y1
Protopopova, M1
Gera, S1
Bandi, M1
Bristow, C1
McAfoos, T1
Morlacchi, P1
Ackroyd, J1
Agip, AA1
Al-Atrash, G1
Asara, J1
Bardenhagen, J1
Carrillo, CC1
Carroll, C1
Chang, E1
Ciurea, S1
Cross, JB1
Czako, B1
Deem, A1
Daver, N1
de Groot, JF1
Dong, JW1
Feng, N1
Gao, G1
Gay, J1
Do, MG1
Greer, J1
Giuliani, V1
Han, J1
Han, L1
Henry, VK1
Hirst, J1
Huang, S1
Jiang, Y1
Kang, Z1
Khor, T1
Konoplev, S1
Lin, YH1
Liu, G1
Lodi, A1
Lofton, T1
Ma, H1
Mahendra, M1
Matre, P1
Mullinax, R1
Peoples, M1
Petrocchi, A1
Rodriguez-Canale, J1
Serreli, R1
Shi, T1
Smith, M1
Tabe, Y1
Theroff, J1
Tiziani, S1
Xu, Q1
Zhang, Q1
Muller, F1
DePinho, RA1
Toniatti, C1
Draetta, GF1
Heffernan, TP1
Konopleva, M2
Jones, P1
Di Francesco, ME1
Marszalek, JR1
Zacharias, NM1
Baran, N1
Shanmugavelandy, SS1
Lee, J1
Lujan, JV1
Dutta, P1
Millward, SW1
Cai, T1
Wood, CG1
Piwnica-Worms, D1
Bhattacharya, PK1
Liu, LL1
Long, ZJ1
Wang, LX1
Zheng, FM1
Fang, ZG1
Yan, M1
Xu, DF1
Chen, JJ1
Wang, SW1
Lin, DJ1
Liu, Q1
Nair, MS1
Mony, U1
Menon, D1
Koyakutty, M1
Sidharthan, N1
Pavithran, K1
Nair, SV1
Menon, KN1
Gu, J1
Yang, S1
Ho, EA1
Blanco, TM1
Mantalaris, A1
Bismarck, A1
Panoskaltsis, N1
Ramzi, J1
Mohamed, Z1
Yosr, B1
Karima, K1
Raihane, B1
Lamia, A1
Hela, BA1
Zaher, B1
Balkis, M1
Hooper, NI1
Tisdale, MJ1
Thornalley, PJ1

Other Studies

14 other studies available for lactic acid and Leukemia, Myeloid, Acute

ArticleYear
Proton export alkalinizes intracellular pH and reprograms carbon metabolism to drive normal and malignant cell growth.
    Blood, 2022, 01-27, Volume: 139, Issue:4

    Topics: Animals; Carbon; Cell Proliferation; Cell Transformation, Neoplastic; Humans; Hydrogen-Ion Concentra

2022
Inhibition of the succinyl dehydrogenase complex in acute myeloid leukemia leads to a lactate-fuelled respiratory metabolic vulnerability.
    Nature communications, 2022, 04-19, Volume: 13, Issue:1

    Topics: Apoptosis; Cell Line, Tumor; fms-Like Tyrosine Kinase 3; Humans; Lactic Acid; Leukemia, Myeloid, Acu

2022
Real-Time NMR Spectroscopy for Studying Metabolism.
    Angewandte Chemie (International ed. in English), 2020, 02-03, Volume: 59, Issue:6

    Topics: Cell Line, Tumor; fms-Like Tyrosine Kinase 3; Glucose; Humans; Lactic Acid; Leukemia, Myeloid, Acute

2020
Role of glucose metabolism in the differential antileukemic effect of melatonin on wild‑type and FLT3‑ITD mutant cells.
    Oncology reports, 2020, Volume: 44, Issue:1

    Topics: Animals; Cell Line, Tumor; Cell Survival; Female; fms-Like Tyrosine Kinase 3; Gene Expression Regula

2020
Could Baking Soda Fight Leukemia Relapse After Stem Cell Transplant?
    JAMA, 2021, Jan-05, Volume: 325, Issue:1

    Topics: Animals; Hematopoietic Stem Cell Transplantation; Humans; Hydrogen-Ion Concentration; Lactic Acid; L

2021
Sudden Unexpected Death in a Child From Acute Myeloid Leukemia.
    The American journal of forensic medicine and pathology, 2021, Jun-01, Volume: 42, Issue:2

    Topics: Acidosis; Anemia; Child, Preschool; Death, Sudden; Female; Gene Rearrangement; Histone-Lysine N-Meth

2021
An inhibitor of oxidative phosphorylation exploits cancer vulnerability.
    Nature medicine, 2018, Volume: 24, Issue:7

    Topics: Animals; Biomarkers, Tumor; Cell Line, Tumor; Energy Metabolism; Glycolysis; HEK293 Cells; Humans; L

2018
Assessing Metabolic Intervention with a Glutaminase Inhibitor in Real-Time by Hyperpolarized Magnetic Resonance in Acute Myeloid Leukemia.
    Molecular cancer therapeutics, 2019, Volume: 18, Issue:11

    Topics: Animals; Benzeneacetamides; Cell Line, Tumor; Cell Proliferation; Cell Survival; HL-60 Cells; Humans

2019
Inhibition of mTOR pathway sensitizes acute myeloid leukemia cells to aurora inhibitors by suppression of glycolytic metabolism.
    Molecular cancer research : MCR, 2013, Volume: 11, Issue:11

    Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Agents; Aurora Kinases; Benzamides; Cell Line,

2013
Development and molecular characterization of polymeric micro-nanofibrous scaffold of a defined 3-D niche for in vitro chemosensitivity analysis against acute myeloid leukemia cells.
    International journal of nanomedicine, 2015, Volume: 10

    Topics: Biphenyl Compounds; Cell Adhesion; Cell Proliferation; Cytarabine; Daunorubicin; Drug Resistance, Ne

2015
Biodegradable Film for the Targeted Delivery of siRNA-Loaded Nanoparticles to Vaginal Immune Cells.
    Molecular pharmaceutics, 2015, Aug-03, Volume: 12, Issue:8

    Topics: Carrageenan; Cell Differentiation; Cell Survival; Cells, Cultured; Dendritic Cells; Female; Genetic

2015
The development of a three-dimensional scaffold for ex vivo biomimicry of human acute myeloid leukaemia.
    Biomaterials, 2010, Volume: 31, Issue:8

    Topics: Animals; Biocompatible Materials; Biomimetic Materials; Bone Marrow Cells; Cell Culture Techniques;

2010
Predictive factors of septic shock and mortality in neutropenic patients.
    Hematology (Amsterdam, Netherlands), 2007, Volume: 12, Issue:6

    Topics: Adult; Bacteremia; Bacteria; Bicarbonates; Female; Fever; Humans; Lactic Acid; Leukemia, Myeloid, Ac

2007
Modification of the glyoxalase system in human HL60 promyelocytic leukaemia cells during differentiation to neutrophils in vitro.
    Biochimica et biophysica acta, 1988, Sep-08, Volume: 966, Issue:3

    Topics: Cell Differentiation; Cell Line; Formamides; Glutathione; Humans; Lactates; Lactic Acid; Lactoylglut

1988