lactic acid has been researched along with Invasiveness, Neoplasm in 60 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In order to enhance the biological activity of α-mangostin, we formulated mangostin-encapsulated PLGA nanoparticles (Mang-NPs) and examined the molecular mechanisms by which they inhibit human and KC mice (Pdx(Cre);LSL-Kras(G12D)) pancreatic CSC characteristics in vitro, and pancreatic carcinogenesis in KPC (Pdx(Cre);LSLKras(G12D);LSL-Trp53(R172H)) mice." | 7.83 | α-Mangostin-encapsulated PLGA nanoparticles inhibit pancreatic carcinogenesis by targeting cancer stem cells in human, and transgenic (Kras(G12D), and Kras(G12D)/tp53R270H) mice. ( Shankar, S; Shrivastava, A; Srivastava, RK; Verma, RK; Yu, W, 2016) |
| "Chemoresistance in breast cancer is a major obstacle, especially in p53 mutation types." | 5.46 | l-arginine alters the effect of 5-fluorouracil on breast cancer cells in favor of apoptosis. ( Azadbakht, M; Jahani, M; Mansouri, K; Norooznezhad, F, 2017) |
| "An increased risk of colorectal cancer is related to the development of metabolic syndromes including hyperglycemia, and hyperinsulinemia." | 5.43 | 2-Deoxyglucose Reverses the Promoting Effect of Insulin on Colorectal Cancer Cells In Vitro. ( Fei, Q; Li, J; Sun, Y; Wang, F; Zhang, C; Zhang, D; Zhu, C, 2016) |
| " In order to enhance the biological activity of α-mangostin, we formulated mangostin-encapsulated PLGA nanoparticles (Mang-NPs) and examined the molecular mechanisms by which they inhibit human and KC mice (Pdx(Cre);LSL-Kras(G12D)) pancreatic CSC characteristics in vitro, and pancreatic carcinogenesis in KPC (Pdx(Cre);LSLKras(G12D);LSL-Trp53(R172H)) mice." | 3.83 | α-Mangostin-encapsulated PLGA nanoparticles inhibit pancreatic carcinogenesis by targeting cancer stem cells in human, and transgenic (Kras(G12D), and Kras(G12D)/tp53R270H) mice. ( Shankar, S; Shrivastava, A; Srivastava, RK; Verma, RK; Yu, W, 2016) |
| "Lactic acid is a byproduct of glycolysis capable of promoting oncogenic progression, but its role in tumor invasion is unclear." | 2.72 | Lactic acid in tumor invasion. ( Luo, T; Niu, D; Wang, H; Xia, Y; Xie, Z, 2021) |
| "Melanoma is a malignant tumor in which UVA (320-400 nm) radiation is considered to be an important risk factor." | 2.53 | UVA-Irradiation Induces Melanoma Invasion via the Enhanced Warburg Effect. ( Baban, TSA; Bauer, J; Berneburg, M; Garbe, C; Kamenisch, Y; Metzler, G; Rocken, M; Schittek, B; Schuller, W; Sinnberg, T; von Thaler, AK, 2016) |
| "Melanoma is the most lethal of all skin-related cancers with incidences continuously rising." | 1.62 | In Vitro Evaluation of CD276-CAR NK-92 Functionality, Migration and Invasion Potential in the Presence of Immune Inhibitory Factors of the Tumor Microenvironment. ( Baden, C; Chan, KC; Grote, S; Handgretinger, R; Mezger, M; Schleicher, S; Ureña-Bailén, G, 2021) |
| "In solid tumors, hypoxia can trigger aberrant expression of transcription factors and genes, resulting in abnormal biological functions such as altered energetic pathways in cancer cells." | 1.56 | Computational modeling to determine key regulators of hypoxia effects on the lactate production in the glycolysis pathway. ( Hashemzadeh, S; Omidi, Y; Rafii-Tabar, H; Shahmorad, S, 2020) |
| "Glioma is a common type of malignant brain tumour with high mortality and relapse rate." | 1.56 | Lactate induced up-regulation of KLHDC8A (Kelch domain-containing 8A) contributes to the proliferation, migration and apoptosis of human glioma cells. ( Chen, T; Lv, K; Yang, H; Zhu, X, 2020) |
| "Since pancreatic cancer is a hypovascular tumor with comparably insufficient energy supply, we further investigate the relationship between PKM2 and hypoglucose." | 1.48 | The responsively decreased PKM2 facilitates the survival of pancreatic cancer cells in hypoglucose. ( Chen, J; Deng, S; He, C; Jin, Y; Li, X; Liu, M; Qin, Q; Wang, C; Zhao, G; Zhu, S, 2018) |
| " However, low aqueous solubility, poor stability and decreased bioavailability associated with native curcumin holds back its use in clinical settings." | 1.48 | Evaluation of curcumin loaded chitosan/PEG blended PLGA nanoparticles for effective treatment of pancreatic cancer. ( Arya, G; Das, M; Sahoo, SK, 2018) |
| "Previously, we reported that human hepatoma cells that harbor OXPHOS defects exhibit high tumor cell invasiveness via elevated claudin-1 (CLN1)." | 1.46 | Lactate-mediated mitoribosomal defects impair mitochondrial oxidative phosphorylation and promote hepatoma cell invasiveness. ( Jeoun, UW; Kwon, SM; Lee, C; Lee, EB; Lee, YK; Lim, JJ; Min, S; Yoon, G, 2017) |
| "Chemoresistance in breast cancer is a major obstacle, especially in p53 mutation types." | 1.46 | l-arginine alters the effect of 5-fluorouracil on breast cancer cells in favor of apoptosis. ( Azadbakht, M; Jahani, M; Mansouri, K; Norooznezhad, F, 2017) |
| "An increased risk of colorectal cancer is related to the development of metabolic syndromes including hyperglycemia, and hyperinsulinemia." | 1.43 | 2-Deoxyglucose Reverses the Promoting Effect of Insulin on Colorectal Cancer Cells In Vitro. ( Fei, Q; Li, J; Sun, Y; Wang, F; Zhang, C; Zhang, D; Zhu, C, 2016) |
| "Therefore, three bladder cancer cell lines with distinct genetic and molecular backgrounds (T24, 5637 and HT1376) were submitted to hypoxia." | 1.43 | Hypoxia enhances the malignant nature of bladder cancer cells and concomitantly antagonizes protein O-glycosylation extension. ( Amaro, T; Azevedo, R; Cotton, S; Fernandes, E; Ferreira, JA; Gaiteiro, C; Lima, L; Neves, M; Oliveira, MJ; Palmeira, C; Parreira, B; Peixoto, A; Rangel, M; Reis, CA; Santos, LL; Silva, AM; Soares, J; Tavares, A; Teixeira, F, 2016) |
| "In addition, miR-203 promoted the metastasis of ovarian cancer cells in vivo and shorted the survival of the nude mice." | 1.43 | MiR-203 promotes the growth and migration of ovarian cancer cells by enhancing glycolytic pathway. ( Kejian, Z; Lichun, F; Na, X; Shaosheng, W; Xiaohong, Z; Xiaolan, X, 2016) |
| "We hypothesized that the progression of bladder cancer could be accompanied by changes in cells glycolytic profile." | 1.42 | The progression from a lower to a higher invasive stage of bladder cancer is associated with severe alterations in glucose and pyruvate metabolism. ( Alves, MG; Conde, VR; Nunes, AR; Oliveira, PF; Pereira, JA; Ramalhosa, E; Rocha, CS; Silva, BM, 2015) |
| "When wild-type KISS1 metastasis suppressor is expressed, aerobic glycolysis decreases and oxidative phosphorylation predominates." | 1.40 | Metastasis suppressor KISS1 seems to reverse the Warburg effect by enhancing mitochondrial biogenesis. ( Ballinger, SW; Beck, BH; Denning, WL; Dhar, A; Diers, AR; Feeley, KP; Iwakuma, T; Landar, A; Liu, W; Nash, KT; Pounds, KM; Vaidya, KS; Welch, DR, 2014) |
| "In addition, we established a colorectal cancer model, and detected CD147 expression in vivo." | 1.39 | Downregulation of CD147 expression by RNA interference inhibits HT29 cell proliferation, invasion and tumorigenicity in vitro and in vivo. ( Deng, Q; Gao, T; He, B; Li, R; Pan, Y; Song, G; Sun, H; Wang, S; Xu, Y, 2013) |
| "As in ovarian cancer cells, increased metabolic activity and glucose concentration has been linked to aggressiveness of cancer." | 1.39 | Therapeutic role of EF24 targeting glucose transporter 1-mediated metabolism and metastasis in ovarian cancer cells. ( Ben, W; Dong, L; Guan, Y; Huang, Y; Lu, M; Ning, N; Wang, Y; Yang, Y; Yuan, J; Zhang, D, 2013) |
| "First, we found that all the SNU human hepatoma cells with increased glycolytic lactate production have the defective mitochondrial respiratory activity and the Cln-1-mediated high invasive activity." | 1.37 | Decreased lactate dehydrogenase B expression enhances claudin 1-mediated hepatoma cell invasiveness via mitochondrial defects. ( Kim, BW; Kim, EL; Kim, JH; Lee, SJ; Lee, YK; Park, CB; Wang, HJ; Yoon, CH; Yoon, G, 2011) |
| "Interestingly, also patients with multiple meningiomas show different spectra of their tumors." | 1.34 | MR spectroscopy in patients with intracranial meningiomas. ( Alfke, K; Buhl, R; Hugo, HH; Jansen, O; Mehdorn, HM; Nabavi, A; Wolff, S, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.67) | 18.7374 |
| 1990's | 1 (1.67) | 18.2507 |
| 2000's | 7 (11.67) | 29.6817 |
| 2010's | 42 (70.00) | 24.3611 |
| 2020's | 9 (15.00) | 2.80 |
| Authors | Studies |
|---|---|
| El-Kenawi, A | 1 |
| Gatenbee, C | 1 |
| Robertson-Tessi, M | 1 |
| Bravo, R | 1 |
| Dhillon, J | 1 |
| Balagurunathan, Y | 1 |
| Berglund, A | 1 |
| Vishvakarma, N | 1 |
| Ibrahim-Hashim, A | 1 |
| Choi, J | 1 |
| Luddy, K | 1 |
| Gatenby, R | 1 |
| Pilon-Thomas, S | 1 |
| Anderson, A | 1 |
| Ruffell, B | 1 |
| Gillies, R | 1 |
| Bhagat, TD | 1 |
| Von Ahrens, D | 1 |
| Dawlaty, M | 1 |
| Zou, Y | 1 |
| Baddour, J | 1 |
| Achreja, A | 1 |
| Zhao, H | 2 |
| Yang, L | 1 |
| Patel, B | 1 |
| Kwak, C | 1 |
| Choudhary, GS | 1 |
| Gordon-Mitchell, S | 1 |
| Aluri, S | 1 |
| Bhattacharyya, S | 1 |
| Sahu, S | 1 |
| Bhagat, P | 1 |
| Yu, Y | 1 |
| Bartenstein, M | 1 |
| Giricz, O | 1 |
| Suzuki, M | 1 |
| Sohal, D | 1 |
| Gupta, S | 1 |
| Guerrero, PA | 1 |
| Batra, S | 1 |
| Goggins, M | 1 |
| Steidl, U | 1 |
| Greally, J | 1 |
| Agarwal, B | 1 |
| Pradhan, K | 1 |
| Banerjee, D | 1 |
| Nagrath, D | 1 |
| Maitra, A | 1 |
| Verma, A | 1 |
| Miranda-Gonçalves, V | 1 |
| Lameirinhas, A | 1 |
| Macedo-Silva, C | 1 |
| Lobo, J | 1 |
| C Dias, P | 1 |
| Ferreira, V | 1 |
| Henrique, R | 1 |
| Jerónimo, C | 1 |
| Hashemzadeh, S | 1 |
| Shahmorad, S | 1 |
| Rafii-Tabar, H | 1 |
| Omidi, Y | 1 |
| Zhu, X | 1 |
| Chen, T | 1 |
| Yang, H | 1 |
| Lv, K | 1 |
| Kalezic, A | 1 |
| Udicki, M | 1 |
| Srdic Galic, B | 1 |
| Aleksic, M | 1 |
| Korac, A | 1 |
| Jankovic, A | 1 |
| Korac, B | 1 |
| Wan, J | 1 |
| Liu, Y | 1 |
| Long, F | 1 |
| Tian, J | 1 |
| Zhang, C | 2 |
| Mu, C | 1 |
| Korenchan, DE | 1 |
| Wang, S | 2 |
| Wilson, DM | 1 |
| Flavell, RR | 1 |
| Grote, S | 1 |
| Ureña-Bailén, G | 1 |
| Chan, KC | 1 |
| Baden, C | 1 |
| Mezger, M | 1 |
| Handgretinger, R | 1 |
| Schleicher, S | 1 |
| Chang, H | 1 |
| Xu, Q | 1 |
| Li, J | 2 |
| Li, M | 1 |
| Zhang, Z | 1 |
| Ma, H | 1 |
| Yang, X | 2 |
| Niu, D | 1 |
| Luo, T | 1 |
| Wang, H | 1 |
| Xia, Y | 1 |
| Xie, Z | 1 |
| Lee, YK | 2 |
| Lim, JJ | 1 |
| Jeoun, UW | 1 |
| Min, S | 1 |
| Lee, EB | 1 |
| Kwon, SM | 1 |
| Lee, C | 1 |
| Yoon, G | 2 |
| Li, X | 1 |
| Deng, S | 2 |
| Liu, M | 1 |
| Jin, Y | 1 |
| Zhu, S | 1 |
| Chen, J | 1 |
| He, C | 1 |
| Qin, Q | 1 |
| Wang, C | 2 |
| Zhao, G | 1 |
| Arya, G | 1 |
| Das, M | 1 |
| Sahoo, SK | 1 |
| Kamenisch, Y | 2 |
| Ivanova, I | 1 |
| Drexler, K | 1 |
| Berneburg, M | 2 |
| Zacharias, N | 1 |
| Lee, J | 1 |
| Ramachandran, S | 1 |
| Shanmugavelandy, S | 1 |
| McHenry, J | 1 |
| Dutta, P | 1 |
| Millward, S | 1 |
| Gammon, S | 1 |
| Efstathiou, E | 1 |
| Troncoso, P | 1 |
| Frigo, DE | 1 |
| Piwnica-Worms, D | 1 |
| Logothetis, CJ | 1 |
| Maity, SN | 1 |
| Titus, MA | 1 |
| Bhattacharya, P | 1 |
| Bhattacharya, R | 1 |
| Ray Chaudhuri, S | 1 |
| Roy, SS | 1 |
| Lenting, K | 1 |
| Khurshed, M | 1 |
| Peeters, TH | 1 |
| van den Heuvel, CNAM | 1 |
| van Lith, SAM | 1 |
| de Bitter, T | 1 |
| Hendriks, W | 1 |
| Span, PN | 1 |
| Molenaar, RJ | 1 |
| Botman, D | 1 |
| Verrijp, K | 1 |
| Heerschap, A | 2 |
| Ter Laan, M | 1 |
| Kusters, B | 1 |
| van Ewijk, A | 1 |
| Huynen, MA | 1 |
| van Noorden, CJF | 1 |
| Leenders, WPJ | 1 |
| Hoffmann, P | 1 |
| Al-Ani, A | 1 |
| von Lueder, T | 1 |
| Hoffmann, J | 1 |
| Majak, P | 1 |
| Hagen, O | 1 |
| Loose, H | 1 |
| Kløw, NE | 1 |
| Opdahl, A | 1 |
| Muli Jogi, RK | 1 |
| Damodharan, K | 1 |
| Leong, HL | 1 |
| Tan, ACS | 1 |
| Chandramohan, S | 1 |
| Venkatanarasimha, NKK | 1 |
| Irani, FG | 1 |
| Patel, A | 1 |
| Gogna, A | 1 |
| Tay, KH | 1 |
| Urlings, TAJ | 1 |
| Magometschnigg, H | 1 |
| Pinker, K | 1 |
| Helbich, T | 1 |
| Brandstetter, A | 1 |
| Rudas, M | 1 |
| Nakuz, T | 1 |
| Baltzer, P | 1 |
| Wadsak, W | 1 |
| Hacker, M | 1 |
| Weber, M | 1 |
| Dubsky, P | 1 |
| Filipits, M | 1 |
| Rodrigues, R | 1 |
| Betelu, S | 1 |
| Colombano, S | 1 |
| Masselot, G | 1 |
| Tzedakis, T | 1 |
| Ignatiadis, I | 1 |
| Liu, X | 2 |
| Huang, Z | 1 |
| Qian, W | 1 |
| Zhang, Q | 1 |
| Sun, J | 1 |
| Schwartz, DL | 1 |
| Tagge, I | 1 |
| Powers, K | 1 |
| Ahn, S | 1 |
| Bakshi, R | 1 |
| Calabresi, PA | 1 |
| Todd Constable, R | 1 |
| Grinstead, J | 1 |
| Henry, RG | 1 |
| Nair, G | 1 |
| Papinutto, N | 1 |
| Pelletier, D | 1 |
| Shinohara, R | 1 |
| Oh, J | 1 |
| Reich, DS | 1 |
| Sicotte, NL | 1 |
| Rooney, WD | 1 |
| Yang, J | 1 |
| Ma, Y | 1 |
| Liu, Z | 1 |
| Li, C | 1 |
| Wang, T | 1 |
| Yan, Z | 1 |
| Du, N | 1 |
| Yan, H | 1 |
| Zhang, S | 1 |
| He, J | 1 |
| Yin, Y | 1 |
| Wang, X | 1 |
| Chen, X | 2 |
| Cui, F | 1 |
| Li, Y | 1 |
| Nie, Y | 1 |
| Tian, W | 1 |
| Feng, C | 1 |
| Gao, Y | 1 |
| Yu, X | 1 |
| Zhang, W | 1 |
| Guan, H | 1 |
| Shan, Z | 1 |
| Teng, W | 1 |
| Li, R | 1 |
| Pan, Y | 1 |
| He, B | 1 |
| Xu, Y | 1 |
| Gao, T | 1 |
| Song, G | 1 |
| Sun, H | 1 |
| Deng, Q | 1 |
| Zhang, D | 2 |
| Wang, Y | 2 |
| Dong, L | 1 |
| Huang, Y | 1 |
| Yuan, J | 1 |
| Ben, W | 1 |
| Yang, Y | 1 |
| Ning, N | 1 |
| Lu, M | 1 |
| Guan, Y | 1 |
| Fogarty, FM | 1 |
| O'Keeffe, J | 1 |
| Zhadanov, A | 1 |
| Papkovsky, D | 1 |
| Ayllon, V | 1 |
| O'Connor, R | 1 |
| Liu, W | 1 |
| Beck, BH | 1 |
| Vaidya, KS | 1 |
| Nash, KT | 1 |
| Feeley, KP | 1 |
| Ballinger, SW | 1 |
| Pounds, KM | 1 |
| Denning, WL | 1 |
| Diers, AR | 1 |
| Landar, A | 1 |
| Dhar, A | 1 |
| Iwakuma, T | 1 |
| Welch, DR | 1 |
| Gallardo-Pérez, JC | 1 |
| Rivero-Segura, NA | 1 |
| Marín-Hernández, A | 1 |
| Moreno-Sánchez, R | 1 |
| Rodríguez-Enríquez, S | 1 |
| Yang, Z | 1 |
| Chen, Z | 1 |
| Chen, R | 1 |
| Zhao, D | 1 |
| Zhou, Y | 1 |
| Qiao, L | 1 |
| Conde, VR | 1 |
| Oliveira, PF | 1 |
| Nunes, AR | 1 |
| Rocha, CS | 1 |
| Ramalhosa, E | 1 |
| Pereira, JA | 1 |
| Alves, MG | 1 |
| Silva, BM | 1 |
| Shukla, SK | 1 |
| Gunda, V | 1 |
| Abrego, J | 1 |
| Haridas, D | 1 |
| Mishra, A | 1 |
| Souchek, J | 1 |
| Chaika, NV | 1 |
| Yu, F | 1 |
| Sasson, AR | 1 |
| Lazenby, AJ | 1 |
| Batra, SK | 1 |
| Singh, PK | 1 |
| Jiang, Y | 1 |
| Wu, GH | 1 |
| He, GD | 1 |
| Zhuang, QL | 1 |
| Xi, QL | 1 |
| Zhang, B | 1 |
| Han, YS | 1 |
| Fang, J | 1 |
| Tao, Y | 1 |
| Tello, JI | 1 |
| Fei, Q | 1 |
| Sun, Y | 2 |
| Zhu, C | 1 |
| Wang, F | 1 |
| Cordani, M | 1 |
| Pacchiana, R | 1 |
| Butera, G | 1 |
| D'Orazi, G | 1 |
| Scarpa, A | 1 |
| Donadelli, M | 1 |
| Gray, AL | 1 |
| Coleman, DT | 1 |
| Shi, R | 1 |
| Cardelli, JA | 1 |
| Baban, TSA | 1 |
| Schuller, W | 1 |
| von Thaler, AK | 1 |
| Sinnberg, T | 1 |
| Metzler, G | 1 |
| Bauer, J | 1 |
| Schittek, B | 1 |
| Garbe, C | 1 |
| Rocken, M | 1 |
| Guo, H | 1 |
| Nan, Y | 1 |
| Zhen, Y | 1 |
| Zhang, Y | 1 |
| Guo, L | 1 |
| Yu, K | 1 |
| Huang, Q | 1 |
| Zhong, Y | 1 |
| Peixoto, A | 1 |
| Fernandes, E | 1 |
| Gaiteiro, C | 1 |
| Lima, L | 1 |
| Azevedo, R | 1 |
| Soares, J | 1 |
| Cotton, S | 1 |
| Parreira, B | 1 |
| Neves, M | 1 |
| Amaro, T | 1 |
| Tavares, A | 1 |
| Teixeira, F | 1 |
| Palmeira, C | 1 |
| Rangel, M | 1 |
| Silva, AM | 1 |
| Reis, CA | 1 |
| Santos, LL | 1 |
| Oliveira, MJ | 1 |
| Ferreira, JA | 1 |
| Verma, RK | 1 |
| Yu, W | 1 |
| Shrivastava, A | 1 |
| Shankar, S | 1 |
| Srivastava, RK | 1 |
| Xiaohong, Z | 1 |
| Lichun, F | 1 |
| Na, X | 1 |
| Kejian, Z | 1 |
| Xiaolan, X | 1 |
| Shaosheng, W | 1 |
| Phannasil, P | 1 |
| Ansari, IH | 1 |
| El Azzouny, M | 1 |
| Longacre, MJ | 1 |
| Rattanapornsompong, K | 1 |
| Burant, CF | 1 |
| MacDonald, MJ | 1 |
| Jitrapakdee, S | 1 |
| Chen, P | 1 |
| Zuo, H | 1 |
| Xiong, H | 1 |
| Kolar, MJ | 1 |
| Chu, Q | 1 |
| Saghatelian, A | 1 |
| Siegwart, DJ | 1 |
| Wan, Y | 1 |
| Jahani, M | 1 |
| Azadbakht, M | 1 |
| Norooznezhad, F | 1 |
| Mansouri, K | 1 |
| Su, J | 1 |
| Kanekura, T | 1 |
| Kos, J | 1 |
| Obermajer, N | 1 |
| Doljak, B | 1 |
| Kocbek, P | 1 |
| Kristl, J | 1 |
| Chernov, MF | 1 |
| Nakaya, K | 1 |
| Kasuya, H | 1 |
| Kato, K | 1 |
| Ono, Y | 1 |
| Yoshida, S | 1 |
| Nakamura, R | 1 |
| Suzuki, T | 1 |
| Muragaki, Y | 1 |
| Iseki, H | 1 |
| Kubo, O | 1 |
| Hori, T | 1 |
| Takakura, K | 1 |
| Kim, JH | 1 |
| Kim, EL | 1 |
| Park, CB | 1 |
| Kim, BW | 1 |
| Wang, HJ | 1 |
| Yoon, CH | 1 |
| Lee, SJ | 1 |
| Yaligar, J | 1 |
| Thakur, SB | 1 |
| Bokacheva, L | 1 |
| Carlin, S | 1 |
| Thaler, HT | 1 |
| Rizwan, A | 1 |
| Lupu, ME | 1 |
| Matei, CC | 1 |
| Zakian, KL | 1 |
| Koutcher, JA | 1 |
| Colen, CB | 1 |
| Shen, Y | 1 |
| Ghoddoussi, F | 1 |
| Yu, P | 1 |
| Francis, TB | 1 |
| Koch, BJ | 1 |
| Monterey, MD | 1 |
| Galloway, MP | 1 |
| Sloan, AE | 1 |
| Mathupala, SP | 1 |
| Mukerjee, A | 1 |
| Shankardas, J | 1 |
| Ranjan, AP | 1 |
| Vishwanatha, JK | 1 |
| Dhup, S | 1 |
| Dadhich, RK | 1 |
| Porporato, PE | 1 |
| Sonveaux, P | 1 |
| Kunz-Schughart, LA | 1 |
| Mueller-Klieser, W | 1 |
| Vaupel, P | 1 |
| Hur, H | 1 |
| Xuan, Y | 1 |
| Kim, YB | 1 |
| Lee, G | 1 |
| Shim, W | 1 |
| Yun, J | 1 |
| Ham, IH | 1 |
| Han, SU | 1 |
| van Horssen, R | 1 |
| Willemse, M | 1 |
| Haeger, A | 1 |
| Attanasio, F | 1 |
| Güneri, T | 1 |
| Schwab, A | 1 |
| Stock, CM | 1 |
| Buccione, R | 1 |
| Fransen, JA | 1 |
| Wieringa, B | 1 |
| Beckner, ME | 1 |
| Gobbel, GT | 1 |
| Abounader, R | 1 |
| Burovic, F | 1 |
| Agostino, NR | 1 |
| Laterra, J | 1 |
| Pollack, IF | 1 |
| Buhl, R | 1 |
| Nabavi, A | 1 |
| Wolff, S | 1 |
| Hugo, HH | 1 |
| Alfke, K | 1 |
| Jansen, O | 1 |
| Mehdorn, HM | 1 |
| Armstrong, CP | 1 |
| Dent, DM | 1 |
| Berman, P | 1 |
| Aitken, RJ | 1 |
| Reshkin, SJ | 1 |
| Bellizzi, A | 1 |
| Albarani, V | 1 |
| Guerra, L | 1 |
| Tommasino, M | 1 |
| Paradiso, A | 1 |
| Casavola, V | 1 |
| Croteau, D | 1 |
| Scarpace, L | 1 |
| Hearshen, D | 1 |
| Gutierrez, J | 1 |
| Fisher, JL | 1 |
| Rock, JP | 1 |
| Mikkelsen, T | 1 |
| Bernsen, HJ | 1 |
| van der Kogel, AJ | 1 |
| van Vaals, JJ | 1 |
| Prick, MJ | 1 |
| Poels, EF | 1 |
| Meyer, J | 1 |
| Grotenhuis, JA | 1 |
8 reviews available for lactic acid and Invasiveness, Neoplasm
| Article | Year |
|---|---|
Tumor Microenvironment Biosensors for Hyperpolarized Carbon-13 Magnetic Resonance Spectroscopy.
Topics: Animals; Biosensing Techniques; Carbon Isotopes; Carbon-13 Magnetic Resonance Spectroscopy; Cold Tem | 2021 |
Lactic acid in tumor invasion.
Topics: Cell Line, Tumor; Cell Movement; Epithelial-Mesenchymal Transition; Humans; Lactic Acid; Neoplasm In | 2021 |
UVA, metabolism and melanoma: UVA makes melanoma hungry for metastasis.
Topics: Animals; Cell Survival; DNA Damage; Glucose; Glycolysis; Humans; Lactic Acid; Melanoma; Mitogen-Acti | 2018 |
Mutant p53 proteins alter cancer cell secretome and tumour microenvironment: Involvement in cancer invasion and metastasis.
Topics: Animals; Cell Communication; Cell Movement; Cytokines; Extracellular Matrix; Genetic Predisposition | 2016 |
UVA-Irradiation Induces Melanoma Invasion via the Enhanced Warburg Effect.
Topics: Blood Glucose; Cell Line, Tumor; Follow-Up Studies; Humans; Lactic Acid; Melanoma; Melanoma, Cutaneo | 2016 |
Multiple biological activities of lactic acid in cancer: influences on tumor growth, angiogenesis and metastasis.
Topics: Humans; Lactic Acid; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms; Neovascularization, Path | 2012 |
[Tumor pathophysiology].
Topics: Animals; Blood Glucose; Cell Hypoxia; Energy Metabolism; Humans; Lactic Acid; Neoplasm Invasiveness; | 2012 |
Image-guided 1H NMR spectroscopical and histological characterization of a human brain tumor model in the nude rat; a new approach to monitor changes in tumor metabolism.
Topics: Animals; Aspartic Acid; Brain Neoplasms; Choline; Energy Metabolism; Glioblastoma; Humans; Lactates; | 1992 |
52 other studies available for lactic acid and Invasiveness, Neoplasm
| Article | Year |
|---|---|
Acidity promotes tumour progression by altering macrophage phenotype in prostate cancer.
Topics: Animals; Bicarbonates; Cell Line, Tumor; Computer Simulation; Cytokines; Disease Progression; Extrac | 2019 |
Lactate-mediated epigenetic reprogramming regulates formation of human pancreatic cancer-associated fibroblasts.
Topics: 5-Methylcytosine; Animals; Cancer-Associated Fibroblasts; Carcinoma, Pancreatic Ductal; Cell Line, T | 2019 |
Lactate Increases Renal Cell Carcinoma Aggressiveness through Sirtuin 1-Dependent Epithelial Mesenchymal Transition Axis Regulation.
Topics: Acetylation; Animals; Biological Transport; Cadherins; Carcinoma, Renal Cell; Cell Line, Tumor; Cell | 2020 |
Computational modeling to determine key regulators of hypoxia effects on the lactate production in the glycolysis pathway.
Topics: Gene Expression; Glycolysis; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Lactic Acid | 2020 |
Lactate induced up-regulation of KLHDC8A (Kelch domain-containing 8A) contributes to the proliferation, migration and apoptosis of human glioma cells.
Topics: Apoptosis; Brain Neoplasms; Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Line, Tumor; Cell Move | 2020 |
Lactate Metabolism in Breast Cancer Microenvironment: Contribution Focused on Associated Adipose Tissue and Obesity.
Topics: Adipose Tissue; Adult; Breast Neoplasms; Carcinoma, Ductal, Breast; Female; Follow-Up Studies; Human | 2020 |
circPVT1 promotes osteosarcoma glycolysis and metastasis by sponging miR-423-5p to activate Wnt5a/Ror2 signaling.
Topics: 3' Untranslated Regions; A549 Cells; Animals; Bone Neoplasms; Cell Movement; Cell Proliferation; Glu | 2021 |
In Vitro Evaluation of CD276-CAR NK-92 Functionality, Migration and Invasion Potential in the Presence of Immune Inhibitory Factors of the Tumor Microenvironment.
Topics: Antigens, Neoplasm; B7 Antigens; Cell Line, Tumor; Cell Movement; CRISPR-Cas Systems; Cytotoxicity, | 2021 |
Lactate secreted by PKM2 upregulation promotes Galectin-9-mediated immunosuppression via inhibiting NF-κB pathway in HNSCC.
Topics: Base Sequence; Carrier Proteins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Galectins; Gen | 2021 |
Lactate-mediated mitoribosomal defects impair mitochondrial oxidative phosphorylation and promote hepatoma cell invasiveness.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Humans; Lactic Acid; Membrane Proteins; Mitochondrial P | 2017 |
The responsively decreased PKM2 facilitates the survival of pancreatic cancer cells in hypoglucose.
Topics: Adenylate Kinase; Autophagy; Carrier Proteins; Cell Line, Tumor; Cell Proliferation; Cell Survival; | 2018 |
Evaluation of curcumin loaded chitosan/PEG blended PLGA nanoparticles for effective treatment of pancreatic cancer.
Topics: Apoptosis; Cell Death; Cell Line, Tumor; Cell Movement; Cell Survival; Chitosan; Curcumin; Endocytos | 2018 |
Androgen Receptor Signaling in Castration-Resistant Prostate Cancer Alters Hyperpolarized Pyruvate to Lactate Conversion and Lactate Levels In Vivo.
Topics: Animals; Disease Models, Animal; Disease Progression; Heterografts; Humans; Image Enhancement; Lacti | 2019 |
FGF9-induced ovarian cancer cell invasion involves VEGF-A/VEGFR2 augmentation by virtue of ETS1 upregulation and metabolic reprogramming.
Topics: Autocrine Communication; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cellular Reprogramming | 2018 |
Isocitrate dehydrogenase 1-mutated human gliomas depend on lactate and glutamate to alleviate metabolic stress.
Topics: 4-Aminobutyrate Transaminase; Animals; Brain Neoplasms; Gene Expression Profiling; Gene Expression R | 2019 |
Topics: A549 Cells; Aged; Apoptosis; Brain; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Non-Smal | 2018 |
MiR-150-5p regulates melanoma proliferation, invasion and metastasis via SIX1-mediated Warburg Effect.
Topics: 3' Untranslated Regions; Adenosine Triphosphate; Base Sequence; Cell Line, Tumor; Cell Proliferation | 2019 |
Self-assembled monolayers with different chemical group substrates for the study of MCF-7 breast cancer cell line behavior.
Topics: Apoptosis; Biocompatible Materials; Breast Neoplasms; Cell Adhesion; Cell Cycle; Cell Movement; Cell | 2013 |
Aberrant overexpression of pyruvate kinase M2 is associated with aggressive tumor features and the BRAF mutation in papillary thyroid cancer.
Topics: Adenosine Triphosphate; Adolescent; Adult; Aged; Animals; Carcinoma, Papillary; Cell Line, Tumor; Ce | 2013 |
Downregulation of CD147 expression by RNA interference inhibits HT29 cell proliferation, invasion and tumorigenicity in vitro and in vivo.
Topics: Antineoplastic Agents; Basigin; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Cisplatin; Col | 2013 |
Therapeutic role of EF24 targeting glucose transporter 1-mediated metabolism and metastasis in ovarian cancer cells.
Topics: Animals; Benzylidene Compounds; Biological Transport; Cell Line, Tumor; Cell Movement; Cell Prolifer | 2013 |
HRG-1 enhances cancer cell invasive potential and couples glucose metabolism to cytosolic/extracellular pH gradient regulation by the vacuolar-H(+) ATPase.
Topics: Cell Membrane; Cytosol; Extracellular Fluid; Glucose; Glucose Transporter Type 1; Hemeproteins; Huma | 2014 |
Metastasis suppressor KISS1 seems to reverse the Warburg effect by enhancing mitochondrial biogenesis.
Topics: Animals; Cell Line, Tumor; Disease Models, Animal; Extracellular Space; Female; Gene Expression; Glu | 2014 |
GPI/AMF inhibition blocks the development of the metastatic phenotype of mature multi-cellular tumor spheroids.
Topics: 3T3 Cells; Adult; Aged; Aged, 80 and over; Animals; Blotting, Western; Breast Neoplasms; Carcinoma, | 2014 |
Effects of the suppression of lactate dehydrogenase A on the growth and invasion of human gastric cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Drug Screenin | 2015 |
The progression from a lower to a higher invasive stage of bladder cancer is associated with severe alterations in glucose and pyruvate metabolism.
Topics: Alanine; Alanine Transaminase; Cell Line, Tumor; Disease Progression; Glucose; Glucose Transporter T | 2015 |
MUC16-mediated activation of mTOR and c-Myc reprograms pancreatic cancer metabolism.
Topics: CA-125 Antigen; Cell Line, Tumor; Cell Movement; Cell Proliferation; Gene Knockdown Techniques; Gluc | 2015 |
The Effect of Silencing HIF-1α Gene in BxPC-3 Cell Line on Glycolysis-Related Gene Expression, Cell Growth, Invasion, and Apoptosis.
Topics: Animals; Apoptosis; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Female; Gene Expression; Gen | 2015 |
Nonlinear stability of a heterogeneous state in a PDE-ODE model for acid-mediated tumor invasion.
Topics: Animals; Cell Movement; Computer Simulation; Humans; Hydrogen-Ion Concentration; Lactic Acid; Models | 2016 |
2-Deoxyglucose Reverses the Promoting Effect of Insulin on Colorectal Cancer Cells In Vitro.
Topics: Adenosine Triphosphate; Apoptosis; Cell Cycle; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Moveme | 2016 |
Monocarboxylate transporter 1 contributes to growth factor-induced tumor cell migration independent of transporter activity.
Topics: Cell Line, Tumor; Cell Movement; Epidermal Growth Factor; Gene Expression Regulation, Neoplastic; He | 2016 |
miRNA-451 inhibits glioma cell proliferation and invasion by downregulating glucose transporter 1.
Topics: Animals; Apoptosis; Biomarkers, Tumor; Blotting, Western; Cell Movement; Cell Proliferation; Fluores | 2016 |
Hypoxia enhances the malignant nature of bladder cancer cells and concomitantly antagonizes protein O-glycosylation extension.
Topics: Adult; Aged; Aged, 80 and over; Antigens, CD; Antigens, Neoplasm; Carbonic Anhydrase IX; Cell Hypoxi | 2016 |
α-Mangostin-encapsulated PLGA nanoparticles inhibit pancreatic carcinogenesis by targeting cancer stem cells in human, and transgenic (Kras(G12D), and Kras(G12D)/tp53R270H) mice.
Topics: Animals; Antigens, CD; Apoptosis; Cadherins; Carcinogenesis; Cell Line, Tumor; Cell Movement; Cell S | 2016 |
MiR-203 promotes the growth and migration of ovarian cancer cells by enhancing glycolytic pathway.
Topics: 3' Untranslated Regions; Animals; Carcinogenesis; Cell Line, Tumor; Cell Movement; Cell Proliferatio | 2016 |
Mass spectrometry analysis shows the biosynthetic pathways supported by pyruvate carboxylase in highly invasive breast cancer cells.
Topics: Acetyl Coenzyme A; Aspartic Acid; Biosynthetic Pathways; Breast Neoplasms; Cell Line, Tumor; Cell Pr | 2017 |
Gpr132 sensing of lactate mediates tumor-macrophage interplay to promote breast cancer metastasis.
Topics: Animals; Breast Neoplasms; Cell Adhesion; Cell Cycle Proteins; Cell Line, Tumor; Cell Movement; Fema | 2017 |
l-arginine alters the effect of 5-fluorouracil on breast cancer cells in favor of apoptosis.
Topics: Apoptosis; Arginine; Breast Neoplasms; Cell Movement; Cell Survival; Chemokine CXCL12; Female; Fluor | 2017 |
A CD147-targeting siRNA inhibits the proliferation, invasiveness, and VEGF production of human malignant melanoma cells by down-regulating glycolysis.
Topics: Basigin; Blotting, Western; Cell Line; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Enzyme | 2009 |
Inactivation of harmful tumour-associated proteolysis by nanoparticulate system.
Topics: Antibodies, Monoclonal; Antibody Specificity; Breast Neoplasms; Caco-2 Cells; Cathepsin B; Cell Adhe | 2009 |
Metabolic alterations in the peritumoral brain in cases of meningiomas: 1H-MRS study.
Topics: Adult; Aged; Aspartic Acid; Brain; Brain Edema; Choline; Female; Humans; Lactic Acid; Lipids; Magnet | 2009 |
Decreased lactate dehydrogenase B expression enhances claudin 1-mediated hepatoma cell invasiveness via mitochondrial defects.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Respiration; Claudin-1; Glycolysis; Humans; Isoenz | 2011 |
Lactate MRSI and DCE MRI as surrogate markers of prostate tumor aggressiveness.
Topics: Animals; Biomarkers, Tumor; Cell Hypoxia; Contrast Media; Immunohistochemistry; Lactic Acid; Magneti | 2012 |
Metabolic targeting of lactate efflux by malignant glioma inhibits invasiveness and induces necrosis: an in vivo study.
Topics: Animals; Antineoplastic Agents; Biological Transport; Brain Neoplasms; Cell Line, Tumor; Coumaric Ac | 2011 |
Efficient nanoparticle mediated sustained RNA interference in human primary endothelial cells.
Topics: Annexin A2; Blotting, Western; Cell Death; Cell Line, Tumor; Down-Regulation; Endocytosis; Endotheli | 2011 |
Expression of pyruvate dehydrogenase kinase-1 in gastric cancer as a potential therapeutic target.
Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Aged; Antimetabolites, Antineoplastic; Blotting, Western; | 2013 |
Intracellular NAD(H) levels control motility and invasion of glioma cells.
Topics: Blotting, Northern; Blotting, Western; Cell Movement; Gene Expression Regulation, Neoplastic; Glioma | 2013 |
Glycolytic glioma cells with active glycogen synthase are sensitive to PTEN and inhibitors of PI3K and gluconeogenesis.
Topics: Astrocytoma; Cell Adhesion; Cell Line, Tumor; Cell Movement; Collagen; Drug Combinations; Enzyme Inh | 2005 |
MR spectroscopy in patients with intracranial meningiomas.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Diagnosis, Differential; Female; Humans; Lactic A | 2007 |
The relationship between gastric carcinoma and gastric juice lactate (L + D) and lactate dehydrogenase.
Topics: Adult; Aged; Carcinoma; Diagnostic Errors; Female; Gastric Acidity Determination; Gastric Juice; Hum | 1984 |
Phosphoinositide 3-kinase is involved in the tumor-specific activation of human breast cancer cell Na(+)/H(+) exchange, motility, and invasion induced by serum deprivation.
Topics: Adenosine Triphosphate; Amiloride; Ammonium Chloride; Androstadienes; Blood; Blotting, Western; Brea | 2000 |
Correlation between magnetic resonance spectroscopy imaging and image-guided biopsies: semiquantitative and qualitative histopathological analyses of patients with untreated glioma.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Dominance, Cerebr | 2001 |