Page last updated: 2024-10-17

lactic acid and Intraocular Pressure

lactic acid has been researched along with Intraocular Pressure in 26 studies

Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.

Intraocular Pressure: The pressure of the fluids in the eye.

Research Excerpts

ExcerptRelevanceReference
"To evaluate the effect of a biodegradable microfilm with sustained release of prednisolone acetate (PA) on postoperative wound healing after experimental glaucoma filtration surgery (GFS)."7.77Evaluation of sustained release of PLC-loaded prednisolone acetate microfilm on postoperative inflammation in an experimental model of glaucoma filtration surgery. ( Ang, M; Foo, S; Venkatraman, SS; Wong, TT; Yan, P; Zhen, M, 2011)
"Ethacrynic acid (ECA) is a potential glaucoma drug that can reduce intraocular pressure."7.72Controlled release of ethacrynic acid from poly(lactide-co-glycolide) films for glaucoma treatment. ( Challa, P; Epstein, DL; Wang, Y; Yuan, F, 2004)
"Dorzolamide was ion paired with sodium dodecyl sulfate (SDS) and sodium oleate (SO) with 0."5.43Subconjunctival Delivery of Dorzolamide-Loaded Poly(ether-anhydride) Microparticles Produces Sustained Lowering of Intraocular Pressure in Rabbits. ( Fridley, C; Fu, J; Gedam, M; Hanes, J; Hu, Q; Liu, W; Liu, Y; Pitha, I; Quigley, HA; Sun, F, 2016)
"Poor drug penetration and rapid clearance after topical instillation of a drug formulation into the eyes are the major causes for the lower ocular bioavailability from conventional eye drops."5.40Dorzolamide-loaded PLGA/vitamin E TPGS nanoparticles for glaucoma therapy: Pharmacoscintigraphy study and evaluation of extended ocular hypotensive effect in rabbits. ( Ahmad, FJ; Anwar, M; Garg, V; Jain, GK; Khar, RK; Talegaonkar, S; Warsi, MH, 2014)
"Dorzolamide eye drops are widely prescribed to reduce intraocular pressure (IOP) in the treatment of ocular hypertension and glaucoma."3.85Enhanced ocular efficacy of topically-delivered dorzolamide with nanostructured mucoadhesive microparticles. ( Choy, YB; Huh, BK; Kim, SN; Kim, YK; Lee, SH; Park, CG; Park, KH; Park, MA; Won, H, 2017)
" We designed and developed a novel drug delivery system (DDS) comprising cyclosporine A (CsA) and poly(lactic-co-glycolic acid) (PLGA) based on a glaucoma drainage device (GDD) that can continuously release CsA to prevent postoperative fibrosis following glaucoma surgery."3.83Development of a novel CsA-PLGA drug delivery system based on a glaucoma drainage device for the prevention of postoperative fibrosis. ( Dai, Z; Hong, J; Liu, X; Sun, J; Sun, X; Yu, X, 2016)
"Melatonin, a neurohormone secreted by the pineal gland, is able to modulate intraocular pressure (IOP)."3.79Polymeric nanoparticles augment the ocular hypotensive effect of melatonin in rabbits. ( Bucolo, C; Carbone, C; Drago, F; Musumeci, T; Pignatello, R; Puglisi, G, 2013)
"To evaluate the effect of a biodegradable microfilm with sustained release of prednisolone acetate (PA) on postoperative wound healing after experimental glaucoma filtration surgery (GFS)."3.77Evaluation of sustained release of PLC-loaded prednisolone acetate microfilm on postoperative inflammation in an experimental model of glaucoma filtration surgery. ( Ang, M; Foo, S; Venkatraman, SS; Wong, TT; Yan, P; Zhen, M, 2011)
"Ethacrynic acid (ECA) is a potential glaucoma drug that can reduce intraocular pressure."3.72Controlled release of ethacrynic acid from poly(lactide-co-glycolide) films for glaucoma treatment. ( Challa, P; Epstein, DL; Wang, Y; Yuan, F, 2004)
"Intraocular pressure was measured using applanation tonometry."2.67Correlates of acute exercise-induced ocular hypotension. ( Harris, A; Malinovsky, V; Martin, B, 1994)
"Dorzolamide was ion paired with sodium dodecyl sulfate (SDS) and sodium oleate (SO) with 0."1.43Subconjunctival Delivery of Dorzolamide-Loaded Poly(ether-anhydride) Microparticles Produces Sustained Lowering of Intraocular Pressure in Rabbits. ( Fridley, C; Fu, J; Gedam, M; Hanes, J; Hu, Q; Liu, W; Liu, Y; Pitha, I; Quigley, HA; Sun, F, 2016)
"Poor drug penetration and rapid clearance after topical instillation of a drug formulation into the eyes are the major causes for the lower ocular bioavailability from conventional eye drops."1.40Dorzolamide-loaded PLGA/vitamin E TPGS nanoparticles for glaucoma therapy: Pharmacoscintigraphy study and evaluation of extended ocular hypotensive effect in rabbits. ( Ahmad, FJ; Anwar, M; Garg, V; Jain, GK; Khar, RK; Talegaonkar, S; Warsi, MH, 2014)
" Our work demonstrated that this new platform is capable of enhancing drug bioavailability and sustaining effective IOP reduction over an extended period of time."1.38Hybrid dendrimer hydrogel/PLGA nanoparticle platform sustains drug delivery for one week and antiglaucoma effects for four days following one-time topical administration. ( Holden, CA; Kadam, RS; Kompella, UB; Tyagi, P; Yang, H, 2012)

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (11.54)18.2507
2000's8 (30.77)29.6817
2010's15 (57.69)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Vohra, R1
Dalgaard, LM1
Vibaek, J1
Langbøl, MA1
Bergersen, LH1
Olsen, NV1
Hassel, B1
Chaudhry, FA1
Kolko, M1
Rodríguez-Agirretxe, I1
Vega, SC1
Rezola, R1
Vecino, E1
Mendicute, J1
Suarez-Cortes, T1
Acera, A1
Pattarini, JM1
Blue, RS1
Aikins, LT1
Law, J1
Walshe, AD1
Garbino, A1
Turney, MW1
Clark, JB1
Warsi, MH1
Anwar, M1
Garg, V1
Jain, GK1
Talegaonkar, S1
Ahmad, FJ1
Khar, RK1
Dai, Z1
Yu, X1
Hong, J1
Liu, X1
Sun, J2
Sun, X1
Fu, J1
Sun, F1
Liu, W1
Liu, Y1
Gedam, M1
Hu, Q1
Fridley, C1
Quigley, HA1
Hanes, J1
Pitha, I1
Park, CG1
Kim, YK1
Kim, SN1
Lee, SH1
Huh, BK1
Park, MA1
Won, H1
Park, KH1
Choy, YB1
Salama, HA1
Ghorab, M1
Mahmoud, AA1
Abdel Hady, M1
Cui, LJ1
Sun, NX1
Li, XH1
Huang, J1
Yang, JG1
Paganelli, F1
Cardillo, JA1
Melo, LA1
Lucena, DR1
Silva, AA1
Oliveira, AG1
Höfling-Lima, AL1
Nguyen, QD1
Kuppermann, BD2
Belfort, R1
Grozdanic, SD1
Lazic, T1
Kuehn, MH1
Harper, MM1
Kardon, RH1
Kwon, YH1
Lavik, EB1
Sakaguchi, DS1
Checa-Casalengua, P1
Jiang, C1
Bravo-Osuna, I1
Tucker, BA1
Molina-Martínez, IT1
Young, MJ1
Herrero-Vanrell, R1
Kruschewsky, Lde S1
Novais, T1
Daltro, C1
Castelo Branco, B1
Lessa, M1
Kruschewsky, MB1
de Mello-Filho, FV1
Ang, M1
Yan, P1
Zhen, M1
Foo, S1
Venkatraman, SS1
Wong, TT1
Doganay, S1
Cankaya, C1
Alkan, A1
Yang, H1
Tyagi, P1
Kadam, RS1
Holden, CA1
Kompella, UB1
Musumeci, T1
Bucolo, C1
Carbone, C1
Pignatello, R1
Drago, F1
Puglisi, G1
Xie, L1
Yao, Z1
Wang, Y1
Challa, P1
Epstein, DL1
Yuan, F1
Blumenkranz, MS1
Haller, JA1
Williams, GA1
Weinberg, DV1
Chou, C1
Whitcup, SM1
Yamashita, T1
Sakamoto, T1
Yamakiri, K1
Miura, M1
Enaida, H1
Ueno, A1
Atsumi, I1
Matsuhisa, K1
Sakamoto, Y1
Kida, T1
Ishibashi, T1
Harris, A1
Malinovsky, V1
Martin, B1
Tan, DT2
Chee, SP2
Lim, L2
Lim, AS1
Lu, DW1
Chang, CJ1
Chiang, CH1
Yeh, MK1
Chou, PI1
Theng, J1
Van Ede, M1
Ashkenazi, I1
Melamed, S1
Blumenthal, M1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Phase I/II Comparative Study of a Single Intraoperative Sub-Tenon's Capsule Injection of Triamcinolone and Ciprofloxacin in a Controlled-Release System Versus 1% Prednisolone and 0.3% Ciprofloxacin Eyedrops for Cataract Surgery[NCT00431028]Phase 1/Phase 2140 participants (Actual)Interventional2005-09-30Terminated (stopped due to Terminated)
Research Study in Patients With Persistent Macular Edema Due to Diabetic Retinopathy, Retinal Vein Occlusion, Uveitis, or Irvine-Gass Syndrome[NCT00035906]Phase 2315 participants (Actual)Interventional2001-10-31Completed
Dexamethasone Intravitreal Implant for Treatment of Macular Edema After Plaque Radiotherapy of Uveal Melanoma[NCT01471054]Phase 26 participants (Actual)Interventional2014-04-30Terminated (stopped due to Could not enroll enough patients.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Central Subfield Retinal Thickness

Increase or decrease in central subfield retinal thickness in microns based on spectral-domain optical coherence tomography measurement (NCT01471054)
Timeframe: At 12 months

Interventionmicron (Median)
Ozurdex-120
Bevacizumab-4

Development of Cataract

Development of visually-significant lens opacity based on judgement of examining physician. (NCT01471054)
Timeframe: At 12 months

InterventionParticipants (Count of Participants)
Ozurdex3
Bevacizumab0

Development of Glaucoma

Intraocular pressure more than 21 mm Hg as measured with applanation tonometry. (NCT01471054)
Timeframe: At 12 months

InterventionParticipants (Count of Participants)
Ozurdex3
Bevacizumab0

Development of Retinal Detachment

Development of rhegmatogenous retinal detachment in the study eye. (NCT01471054)
Timeframe: At 12 months

InterventionParticipants (Count of Participants)
Ozurdex0
Bevacizumab0

Development of Vitreous Hemorrhage

Development of hemorrhage in the vitreous cavity detectable with slit lamp examination or dilated funduscopy. (NCT01471054)
Timeframe: At 12 months

InterventionParticipants (Count of Participants)
Ozurdex0
Bevacizumab0

Number of Participants for Whom Study Eye Showed >=2 Lines of Improvement in Best-corrected Visual Acuity

The number of participants that developed 2 or more lines of visual acuity improvement in the study eye. Visual acuity was measured with Snellen eye chart placed 10 feet away from the patient. (NCT01471054)
Timeframe: At 12 months

Interventionparticipants (Number)
Ozurdex2
Bevacizumab0

Reviews

1 review available for lactic acid and Intraocular Pressure

ArticleYear
Flat spin and negative Gz in high-altitude free fall: pathophysiology, prevention, and treatment.
    Aviation, space, and environmental medicine, 2013, Volume: 84, Issue:9

    Topics: Altitude; Arrhythmias, Cardiac; Blood Glucose; Brain Edema; Cerebrovascular Circulation; Confusion;

2013

Trials

6 trials available for lactic acid and Intraocular Pressure

ArticleYear
A single intraoperative sub-tenon's capsule injection of triamcinolone and ciprofloxacin in a controlled-release system for cataract surgery.
    Investigative ophthalmology & visual science, 2009, Volume: 50, Issue:7

    Topics: Aged; Anterior Chamber; Anti-Infective Agents; Anti-Inflammatory Agents; Ciprofloxacin; Connective T

2009
Fractured orbital wall reconstruction with an auricular cartilage graft or absorbable polyacid copolymer.
    The Journal of craniofacial surgery, 2011, Volume: 22, Issue:4

    Topics: Absorbable Implants; Adult; Biocompatible Materials; Diplopia; Ear Cartilage; Ectropion; Enophthalmo

2011
Randomized controlled study of an intravitreous dexamethasone drug delivery system in patients with persistent macular edema.
    Archives of ophthalmology (Chicago, Ill. : 1960), 2007, Volume: 125, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Biocompatible Materials; Dexamethasone; Double-Blind Met

2007
Randomized controlled study of an intravitreous dexamethasone drug delivery system in patients with persistent macular edema.
    Archives of ophthalmology (Chicago, Ill. : 1960), 2007, Volume: 125, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Biocompatible Materials; Dexamethasone; Double-Blind Met

2007
Randomized controlled study of an intravitreous dexamethasone drug delivery system in patients with persistent macular edema.
    Archives of ophthalmology (Chicago, Ill. : 1960), 2007, Volume: 125, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Biocompatible Materials; Dexamethasone; Double-Blind Met

2007
Randomized controlled study of an intravitreous dexamethasone drug delivery system in patients with persistent macular edema.
    Archives of ophthalmology (Chicago, Ill. : 1960), 2007, Volume: 125, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Biocompatible Materials; Dexamethasone; Double-Blind Met

2007
Correlates of acute exercise-induced ocular hypotension.
    Investigative ophthalmology & visual science, 1994, Volume: 35, Issue:11

    Topics: Betaxolol; Blood Pressure; Exercise; Female; Heart Rate; Humans; Intraocular Pressure; Lactates; Lac

1994
Randomized clinical trial of a new dexamethasone delivery system (Surodex) for treatment of post-cataract surgery inflammation.
    Ophthalmology, 1999, Volume: 106, Issue:2

    Topics: Aged; Anterior Chamber; Anti-Inflammatory Agents; Biocompatible Materials; Cataract Extraction; Cell

1999
Randomized clinical trial of Surodex steroid drug delivery system for cataract surgery: anterior versus posterior placement of two Surodex in the eye.
    Ophthalmology, 2001, Volume: 108, Issue:12

    Topics: Aged; Anterior Chamber; Biocompatible Materials; Cataract Extraction; Dexamethasone; Double-Blind Me

2001

Other Studies

19 other studies available for lactic acid and Intraocular Pressure

ArticleYear
Potential metabolic markers in glaucoma and their regulation in response to hypoxia.
    Acta ophthalmologica, 2019, Volume: 97, Issue:6

    Topics: Aged; Amino Acids; Biomarkers; Blood Glucose; Chromatography, High Pressure Liquid; Female; Glaucoma

2019
The PLGA implant as an antimitotic delivery system after experimental trabeculectomy.
    Investigative ophthalmology & visual science, 2013, Aug-05, Volume: 54, Issue:8

    Topics: Animals; Antimitotic Agents; Coated Materials, Biocompatible; Conjunctiva; Disease Models, Animal; D

2013
Dorzolamide-loaded PLGA/vitamin E TPGS nanoparticles for glaucoma therapy: Pharmacoscintigraphy study and evaluation of extended ocular hypotensive effect in rabbits.
    Colloids and surfaces. B, Biointerfaces, 2014, Oct-01, Volume: 122

    Topics: Animals; Carbonic Anhydrase Inhibitors; Glaucoma; Intraocular Pressure; Lactic Acid; Microscopy, Ele

2014
Development of a novel CsA-PLGA drug delivery system based on a glaucoma drainage device for the prevention of postoperative fibrosis.
    Materials science & engineering. C, Materials for biological applications, 2016, Sep-01, Volume: 66

    Topics: Animals; Cell Survival; Cells, Cultured; Chromatography, High Pressure Liquid; Cyclosporine; Drainag

2016
Subconjunctival Delivery of Dorzolamide-Loaded Poly(ether-anhydride) Microparticles Produces Sustained Lowering of Intraocular Pressure in Rabbits.
    Molecular pharmaceutics, 2016, 09-06, Volume: 13, Issue:9

    Topics: Animals; Antihypertensive Agents; Carbonic Anhydrase Inhibitors; Ethylamines; Female; Glaucoma; Intr

2016
Enhanced ocular efficacy of topically-delivered dorzolamide with nanostructured mucoadhesive microparticles.
    International journal of pharmaceutics, 2017, Apr-30, Volume: 522, Issue:1-2

    Topics: Adhesives; Administration, Ophthalmic; Administration, Topical; Animals; Carbonic Anhydrase Inhibito

2017
PLGA Nanoparticles as Subconjunctival Injection for Management of Glaucoma.
    AAPS PharmSciTech, 2017, Volume: 18, Issue:7

    Topics: Animals; Conjunctiva; Drug Carriers; Drug Delivery Systems; Drug Liberation; Glaucoma; Intraocular P

2017
Subconjunctival sustained release 5-fluorouracil for glaucoma filtration surgery.
    Acta pharmacologica Sinica, 2008, Volume: 29, Issue:9

    Topics: Animals; Antimetabolites; Aqueous Humor; Chromatography, High Pressure Liquid; Conjunctiva; Delayed-

2008
Exogenous modulation of intrinsic optic nerve neuroprotective activity.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2010, Volume: 248, Issue:8

    Topics: Animals; Brain-Derived Neurotrophic Factor; Cell Survival; Ciliary Neurotrophic Factor; Disease Mode

2010
Retinal ganglion cells survival in a glaucoma model by GDNF/Vit E PLGA microspheres prepared according to a novel microencapsulation procedure.
    Journal of controlled release : official journal of the Controlled Release Society, 2011, Nov-30, Volume: 156, Issue:1

    Topics: Animals; Cell Survival; Cells, Cultured; Disease Models, Animal; Drug Carriers; Drug Combinations; D

2011
Evaluation of sustained release of PLC-loaded prednisolone acetate microfilm on postoperative inflammation in an experimental model of glaucoma filtration surgery.
    Current eye research, 2011, Volume: 36, Issue:12

    Topics: Animals; Delayed-Action Preparations; Disease Models, Animal; Drug Carriers; Endophthalmitis; Female

2011
Evaluation of corpus geniculatum laterale and vitreous fluid by magnetic resonance spectroscopy in patients with glaucoma; a preliminary study.
    Eye (London, England), 2012, Volume: 26, Issue:8

    Topics: Aged; Apoptosis; Aspartic Acid; Choline; Creatine; Female; Geniculate Bodies; Glaucoma, Open-Angle;

2012
Hybrid dendrimer hydrogel/PLGA nanoparticle platform sustains drug delivery for one week and antiglaucoma effects for four days following one-time topical administration.
    ACS nano, 2012, Sep-25, Volume: 6, Issue:9

    Topics: Administration, Topical; Animals; Antihypertensive Agents; Delayed-Action Preparations; Dendrimers;

2012
Polymeric nanoparticles augment the ocular hypotensive effect of melatonin in rabbits.
    International journal of pharmaceutics, 2013, Jan-20, Volume: 440, Issue:2

    Topics: Administration, Ophthalmic; Animals; Delayed-Action Preparations; Drug Carriers; Drug Compounding; D

2013
Heparin drug delivery system for prevention of posterior capsular opacification in rabbit eyes.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2003, Volume: 241, Issue:4

    Topics: Animals; Aqueous Humor; Biocompatible Materials; Cataract; Drug Delivery Systems; Drug Implants; Fib

2003
Controlled release of ethacrynic acid from poly(lactide-co-glycolide) films for glaucoma treatment.
    Biomaterials, 2004, Volume: 25, Issue:18

    Topics: Absorption; Animals; Delayed-Action Preparations; Diffusion; Drug Evaluation, Preclinical; Ethacryni

2004
Polylactic acid for visualizing the vitreous body during vitrectomy.
    Investigative ophthalmology & visual science, 2007, Volume: 48, Issue:7

    Topics: Animals; Anterior Eye Segment; Contrast Media; Electroretinography; Injections; Intraocular Pressure

2007
Wound modulation after trabeculectomy by different formulations of antimetabolites in rabbits.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2000, Volume: 16, Issue:6

    Topics: Animals; Antimetabolites; Biocompatible Materials; Conjunctiva; Dose-Response Relationship, Drug; Dr

2000
The effect of continuous strenuous exercise on intraocular pressure.
    Investigative ophthalmology & visual science, 1992, Volume: 33, Issue:10

    Topics: Adult; Blood Physiological Phenomena; Humans; Hydrogen-Ion Concentration; Intraocular Pressure; Lact

1992