lactic acid has been researched along with Intracranial Hypertension in 32 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Intracranial Hypertension: Increased pressure within the cranial vault. This may result from several conditions, including HYDROCEPHALUS; BRAIN EDEMA; intracranial masses; severe systemic HYPERTENSION; PSEUDOTUMOR CEREBRI; and other disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We assess the effects of ipsapirone (a 5-HT1A receptor agonist), ketanserin (a 5-HT2A receptor antagonist), (-)-pindolol (a 5-HT1A receptor antagonist), and DOI (a 5-HT2A receptor agonist) on heatstroke in a rat model." | 7.73 | Ipsapirone and ketanserin protects against circulatory shock, intracranial hypertension, and cerebral ischemia during heatstroke. ( Chang, CP; Chen, SH; Lin, MT, 2005) |
| "In contrast, all vehicle-treated heatstroke animals had lower levels of MAP, cerebral perfusion pressure, cerebral blood flow, and brain partial pressure of oxygen." | 5.35 | L-arginine causes amelioration of cerebrovascular dysfunction and brain inflammation during experimental heatstroke. ( Chen, YC; Huang, CI; Lee, CH; Lin, MT; Liu, YC; Wang, LM; Yen, DH, 2008) |
| " Despite the use of barbiturate coma in patients with refractory intracranial hypertension, persistent release or impaired uptake of glutamate may be associated with continuous anaerobic metabolism, as shown by increases in cerebrospinal fluid hypoxanthine and lactate levels." | 5.09 | Thiopental attenuates energetic impairment but fails to normalize cerebrospinal fluid glutamate in brain-injured patients. ( Kossmann, T; Morganti-Kossmann, MC; Pleines, UE; Stocker, R; Stover, JF, 1999) |
| "Hyperammonemia causes brain edema and high intracranial pressure (ICP) in acute liver failure (ALF) by accumulation of glutamine in brain." | 3.74 | Cerebral glutamine concentration and lactate-pyruvate ratio in patients with acute liver failure. ( Bjerring, PN; Frederiksen, HJ; Hansen, BA; Hauerberg, J; Jorgensen, L; Larsen, FS; Tofteng, F, 2008) |
| "An LP ratio >25 and glycerol >100 micromol/L, but not glutamate >12 micromol/L, were associated with significantly higher risk of imminent intracranial hypertension (odds ratio: 9." | 3.74 | Metabolic failure precedes intracranial pressure rises in traumatic brain injury: a microdialysis study. ( Belli, A; Kitchen, N; Petzold, A; Russo, S; Sen, J; Smith, M, 2008) |
| "We assess the effects of ipsapirone (a 5-HT1A receptor agonist), ketanserin (a 5-HT2A receptor antagonist), (-)-pindolol (a 5-HT1A receptor antagonist), and DOI (a 5-HT2A receptor agonist) on heatstroke in a rat model." | 3.73 | Ipsapirone and ketanserin protects against circulatory shock, intracranial hypertension, and cerebral ischemia during heatstroke. ( Chang, CP; Chen, SH; Lin, MT, 2005) |
| "SL is an effective therapy for treating brain edema after TBI." | 1.62 | The Antiedematous Effect of Exogenous Lactate Therapy in Traumatic Brain Injury: A Physiological and Mechanistic Approach. ( Duhaut, DE; Gandin, C; Heurteaux, C; Ichai, C; Quintard, H, 2021) |
| " In a separate dose-response experiment cortex from healthy rats was incubated for 120 min in ammonium acetate in concentrations up to 80 mM prior to respirometry." | 1.46 | Accumulation of lactate in the rat brain during hyperammonaemia is not associated with impaired mitochondrial respiratory capacity. ( Bjerring, PN; Larsen, FS; Witt, AM, 2017) |
| "Cerebral edema is a well-recognized and potentially fatal complication of acute liver failure (ALF)." | 1.39 | Cerebral microdialysis reflects the neuroprotective effect of fractionated plasma separation and adsorption in acute liver failure better and earlier than intracranial pressure: a controlled study in pigs. ( Koblihova, E; Laszikova, E; Pantoflicek, T; Prazak, J; Ryska, M; Ryska, O, 2013) |
| "Patients with acute liver failure have a disturbed amino acid metabolism and a compromised oxidative metabolism in the brain." | 1.38 | The effect of fractionated plasma separation and adsorption on cerebral amino acid metabolism and oxidative metabolism during acute liver failure. ( Bjerring, PN; Clemmesen, JO; Frederiksen, HJ; Hauerberg, J; Larsen, FS; Nielsen, HB, 2012) |
| "Patients with acute liver failure (ALF) often die of intracranial pressure (IP) and cerebral herniation." | 1.37 | Brain region-selective mechanisms contribute to the progression of cerebral alterations in acute liver failure in rats. ( Agusti, A; Boix, J; Cauli, O; Cerdán, S; Felipo, V; López-Larrubia, P; Nieto-Charques, L; Rodrigo, R, 2011) |
| "When biochemical signs of cerebral ischemia progressed, i." | 1.37 | Prostacyclin infusion may prevent secondary damage in pericontusional brain tissue. ( Nordström, CH; Reinstrup, P, 2011) |
| "The pathogenesis of cerebral edema in acute liver failure is suggested, in in vitro and animal studies, to involve a compromised oxidative metabolism with a decrease in cerebral ATP levels and an increase in purine concentrations." | 1.36 | Brain hypoxanthine concentration correlates to lactate/pyruvate ratio but not intracranial pressure in patients with acute liver failure. ( Bjerring, PN; Frederiksen, HJ; Hansen, BA; Hauerberg, J; Jørgensen, L; Larsen, FS; Tofteng, F, 2010) |
| "In contrast, all vehicle-treated heatstroke animals had lower levels of MAP, cerebral perfusion pressure, cerebral blood flow, and brain partial pressure of oxygen." | 1.35 | L-arginine causes amelioration of cerebrovascular dysfunction and brain inflammation during experimental heatstroke. ( Chen, YC; Huang, CI; Lee, CH; Lin, MT; Liu, YC; Wang, LM; Yen, DH, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (12.50) | 18.2507 |
| 2000's | 17 (53.13) | 29.6817 |
| 2010's | 10 (31.25) | 24.3611 |
| 2020's | 1 (3.13) | 2.80 |
| Authors | Studies |
|---|---|
| Duhaut, DE | 1 |
| Heurteaux, C | 1 |
| Gandin, C | 1 |
| Ichai, C | 1 |
| Quintard, H | 1 |
| Cesak, T | 1 |
| Adamkov, J | 1 |
| Habalova, J | 1 |
| Poczos, P | 1 |
| Kanta, M | 1 |
| Bartos, M | 1 |
| Hosszu, T | 1 |
| Prazak, J | 2 |
| Laszikova, E | 2 |
| Pantoflicek, T | 2 |
| Ryska, O | 2 |
| Koblihova, E | 2 |
| Ryska, M | 2 |
| Bouzat, P | 1 |
| Oddo, M | 1 |
| Alosh, H | 1 |
| Ramirez, A | 1 |
| Mink, R | 1 |
| Witt, AM | 1 |
| Larsen, FS | 5 |
| Bjerring, PN | 4 |
| Brody, DL | 1 |
| Magnoni, S | 1 |
| Schwetye, KE | 1 |
| Spinner, ML | 1 |
| Esparza, TJ | 1 |
| Stocchetti, N | 1 |
| Zipfel, GJ | 1 |
| Holtzman, DM | 1 |
| Nagel, A | 1 |
| Graetz, D | 1 |
| Schink, T | 1 |
| Frieler, K | 1 |
| Sakowitz, O | 1 |
| Vajkoczy, P | 1 |
| Sarrafzadeh, A | 1 |
| Timofeev, I | 1 |
| Dahyot-Fizelier, C | 1 |
| Keong, N | 1 |
| Nortje, J | 1 |
| Al-Rawi, PG | 1 |
| Czosnyka, M | 1 |
| Menon, DK | 1 |
| Kirkpatrick, PJ | 1 |
| Gupta, AK | 1 |
| Hutchinson, PJ | 1 |
| Adamides, AA | 1 |
| Rosenfeldt, FL | 1 |
| Winter, CD | 1 |
| Pratt, NM | 1 |
| Tippett, NJ | 1 |
| Lewis, PM | 1 |
| Bailey, MJ | 1 |
| Cooper, DJ | 1 |
| Rosenfeld, JV | 1 |
| Hauerberg, J | 3 |
| Jørgensen, L | 1 |
| Frederiksen, HJ | 3 |
| Tofteng, F | 3 |
| Hansen, BA | 3 |
| Cauli, O | 1 |
| López-Larrubia, P | 1 |
| Rodrigo, R | 1 |
| Agusti, A | 1 |
| Boix, J | 1 |
| Nieto-Charques, L | 1 |
| Cerdán, S | 1 |
| Felipo, V | 1 |
| Reinstrup, P | 1 |
| Nordström, CH | 1 |
| Nielsen, HB | 1 |
| Clemmesen, JO | 1 |
| Jorgensen, L | 2 |
| Ott, P | 1 |
| Kondrup, J | 1 |
| Tolias, CM | 1 |
| Reinert, M | 2 |
| Seiler, R | 1 |
| Gilman, C | 2 |
| Scharf, A | 1 |
| Bullock, MR | 1 |
| Chang, CP | 1 |
| Chen, SH | 1 |
| Lin, MT | 2 |
| Soustiel, JF | 1 |
| Mahamid, E | 1 |
| Chistyakov, A | 1 |
| Shik, V | 1 |
| Benenson, R | 1 |
| Zaaroor, M | 1 |
| Salci, K | 1 |
| Nilsson, P | 1 |
| Goiny, M | 1 |
| Contant, C | 1 |
| Piper, I | 1 |
| Enblad, P | 1 |
| Khaldi, A | 1 |
| Zauner, A | 2 |
| Doppenberg, E | 1 |
| Choi, S | 1 |
| Bullock, R | 2 |
| Chen, YC | 1 |
| Liu, YC | 1 |
| Yen, DH | 1 |
| Wang, LM | 1 |
| Huang, CI | 1 |
| Lee, CH | 1 |
| Zoremba, N | 1 |
| Schnoor, J | 1 |
| Berens, M | 1 |
| Kuhlen, R | 1 |
| Rossaint, R | 1 |
| Vespa, PM | 1 |
| Miller, C | 1 |
| McArthur, D | 1 |
| Eliseo, M | 1 |
| Etchepare, M | 1 |
| Hirt, D | 1 |
| Glenn, TC | 1 |
| Martin, N | 1 |
| Hovda, D | 1 |
| Belli, A | 1 |
| Sen, J | 1 |
| Petzold, A | 1 |
| Russo, S | 1 |
| Kitchen, N | 1 |
| Smith, M | 1 |
| Nyberg, SL | 1 |
| Cerra, FB | 1 |
| Gruetter, R | 1 |
| Valadka, AB | 1 |
| Goodman, JC | 1 |
| Gopinath, SP | 1 |
| Uzura, M | 1 |
| Robertson, CS | 1 |
| Stover, JF | 1 |
| Pleines, UE | 1 |
| Morganti-Kossmann, MC | 1 |
| Stocker, R | 1 |
| Kossmann, T | 1 |
| Glass, TF | 1 |
| Fabian, MJ | 1 |
| Schweitzer, JB | 1 |
| Weinberg, JA | 1 |
| Proctor, KG | 1 |
| Schneweis, S | 1 |
| Grond, M | 1 |
| Staub, F | 1 |
| Brinker, G | 1 |
| Neveling, M | 1 |
| Dohmen, C | 1 |
| Graf, R | 1 |
| Heiss, WD | 1 |
| Soukup, J | 1 |
| Doppenberg, EM | 1 |
| Menzel, M | 1 |
| Young, HF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Uncovering the 'ORIGINS' of Diabetes[NCT02226640] | 80 participants (Actual) | Observational | 2010-11-30 | Completed | |||
| Cerebral Microdialysis in Patients With Fulminant Hepatic Failure[NCT00836420] | 50 participants (Actual) | Observational | 2000-01-31 | Completed | |||
| Conservative vs Conventional Oxygen Administration in Critically Ill Patients: Effects on ICU Mortality. A Multicentre Randomized Open Label Clinical Trial[NCT04198077] | Phase 4 | 1,000 participants (Anticipated) | Interventional | 2019-12-04 | Recruiting | ||
| Impact of Intermediate Normal Compared to High Normal Oxygen Levels on Outcomes of Patients Presenting in the Emergency Department With Severe Traumatic Brain Injury (INACHOS): a Pilot Randomized Controlled Trial[NCT05464277] | 50 participants (Anticipated) | Interventional | 2022-08-31 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for lactic acid and Intracranial Hypertension
| Article | Year |
|---|---|
Lactate and the injured brain: friend or foe?
Topics: Brain Injuries; Cerebral Cortex; Cerebrovascular Circulation; Energy Metabolism; Female; Glycolysis; | 2014 |
4 trials available for lactic acid and Intracranial Hypertension
| Article | Year |
|---|---|
Ventriculostomy for control of raised ICP in acute traumatic brain injury.
Topics: Adult; Blood Pressure; Brain Injuries; Cerebrospinal Fluid; Female; Glasgow Coma Scale; Humans; Intr | 2008 |
Comparison of moderate hyperventilation and mannitol for control of intracranial pressure control in patients with severe traumatic brain injury--a study of cerebral blood flow and metabolism.
Topics: Adolescent; Adult; Aged; Brain Edema; Brain Injuries; Brain Ischemia; Cerebral Cortex; Cerebrovascul | 2006 |
Thiopental attenuates energetic impairment but fails to normalize cerebrospinal fluid glutamate in brain-injured patients.
Topics: Adolescent; Adult; Biomarkers; Brain Injuries; Electroencephalography; Female; Glutamic Acid; Humans | 1999 |
Predictive value of neurochemical monitoring in large middle cerebral artery infarction.
Topics: Adult; Aged; Brain Edema; Critical Care; Electrodes, Implanted; Extracellular Space; Female; Frontal | 2001 |
27 other studies available for lactic acid and Intracranial Hypertension
| Article | Year |
|---|---|
The Antiedematous Effect of Exogenous Lactate Therapy in Traumatic Brain Injury: A Physiological and Mechanistic Approach.
Topics: Animals; Brain Edema; Brain Injuries, Traumatic; Intracranial Hypertension; Intracranial Pressure; L | 2021 |
The relationship between intracranial pressure and lactate/pyruvate ratio in patients with subarachnoid haemorrhage.
Topics: Aneurysm, Ruptured; Brain; Humans; Intracranial Aneurysm; Intracranial Hypertension; Intracranial Pr | 2018 |
Cerebral microdialysis reflects the neuroprotective effect of fractionated plasma separation and adsorption in acute liver failure better and earlier than intracranial pressure: a controlled study in pigs.
Topics: Ammonia; Animals; Brain Edema; Cerebrum; Extracorporeal Circulation; Glucose; Glutamic Acid; Glutami | 2013 |
The correlation between brain near-infrared spectroscopy and cerebral blood flow in piglets with intracranial hypertension.
Topics: Animals; Brain; Cerebrovascular Circulation; Female; Glucose; Intracranial Hypertension; Intracrania | 2016 |
Accumulation of lactate in the rat brain during hyperammonaemia is not associated with impaired mitochondrial respiratory capacity.
Topics: Animals; Biosensing Techniques; Brain Chemistry; Cerebral Cortex; Citric Acid Cycle; Encephalitis; H | 2017 |
Amyloid-beta dynamics correlate with neurological status in the injured human brain.
Topics: Amyloid beta-Peptides; Brain; Brain Injuries; Extracellular Fluid; Glasgow Coma Scale; Glucose; Huma | 2008 |
Relevance of intracranial hypertension for cerebral metabolism in aneurysmal subarachnoid hemorrhage. Clinical article.
Topics: Adult; Brain; Brain Diseases; Craniotomy; Decompression, Surgical; Energy Metabolism; Female; Glutam | 2009 |
Brain tissue lactate elevations predict episodes of intracranial hypertension in patients with traumatic brain injury.
Topics: Adolescent; Adult; Aged; Area Under Curve; Australia; Biomarkers; Brain; Brain Injuries; Dermatitis, | 2009 |
Brain hypoxanthine concentration correlates to lactate/pyruvate ratio but not intracranial pressure in patients with acute liver failure.
Topics: Adolescent; Adult; Brain; Brain Edema; Female; Humans; Hyperammonemia; Hypoxanthine; Inosine; Intrac | 2010 |
Brain region-selective mechanisms contribute to the progression of cerebral alterations in acute liver failure in rats.
Topics: Ammonia; Animals; Blood-Brain Barrier; Brain Edema; Capillary Permeability; Cerebellum; Cerebrum; En | 2011 |
Prostacyclin infusion may prevent secondary damage in pericontusional brain tissue.
Topics: Blood Glucose; Brain Concussion; Brain Damage, Chronic; Brain Edema; Brain Ischemia; Epoprostenol; F | 2011 |
Artificial liver support system reduces intracranial pressure more effectively than bioartificial system: an experimental study.
Topics: Ammonia; Animals; Bilirubin; Biomarkers; Cerebrovascular Circulation; Disease Models, Animal; Equipm | 2012 |
The effect of fractionated plasma separation and adsorption on cerebral amino acid metabolism and oxidative metabolism during acute liver failure.
Topics: Adult; Amino Acids; Cerebrum; Dialysis Solutions; Extracorporeal Circulation; Female; Glutamine; Hep | 2012 |
Cerebral microdialysis in patients with fulminant hepatic failure.
Topics: Adult; Female; Glutamic Acid; Humans; Hyperventilation; Hypnotics and Sedatives; Hypothermia, Induce | 2002 |
Normobaric hyperoxia--induced improvement in cerebral metabolism and reduction in intracranial pressure in patients with severe head injury: a prospective historical cohort-matched study.
Topics: Adolescent; Adult; Aged; Blood Glucose; Brain; Brain Injuries; Cohort Studies; Critical Care; Energy | 2004 |
Normobaric hyperoxia--induced improvement in cerebral metabolism and reduction in intracranial pressure in patients with severe head injury: a prospective historical cohort-matched study.
Topics: Adolescent; Adult; Aged; Blood Glucose; Brain; Brain Injuries; Cohort Studies; Critical Care; Energy | 2004 |
Normobaric hyperoxia--induced improvement in cerebral metabolism and reduction in intracranial pressure in patients with severe head injury: a prospective historical cohort-matched study.
Topics: Adolescent; Adult; Aged; Blood Glucose; Brain; Brain Injuries; Cohort Studies; Critical Care; Energy | 2004 |
Normobaric hyperoxia--induced improvement in cerebral metabolism and reduction in intracranial pressure in patients with severe head injury: a prospective historical cohort-matched study.
Topics: Adolescent; Adult; Aged; Blood Glucose; Brain; Brain Injuries; Cohort Studies; Critical Care; Energy | 2004 |
Ipsapirone and ketanserin protects against circulatory shock, intracranial hypertension, and cerebral ischemia during heatstroke.
Topics: Anesthesia; Animals; Brain; Brain Ischemia; Corpus Striatum; Disease Models, Animal; Glutamic Acid; | 2005 |
Low intracranial compliance increases the impact of intracranial volume insults to the traumatized brain: a microdialysis study in a traumatic brain injury rodent model.
Topics: Animals; Biomarkers; Brain; Brain Chemistry; Brain Edema; Brain Injuries; Cell Membrane; Cerebral He | 2006 |
High extracellular potassium and its correlates after severe head injury: relationship to high intracranial pressure.
Topics: Adolescent; Adult; Astrocytes; Brain; Brain Edema; Brain Injuries; Cerebrovascular Circulation; Cran | 2000 |
L-arginine causes amelioration of cerebrovascular dysfunction and brain inflammation during experimental heatstroke.
Topics: Animals; Arginine; Cerebrovascular Circulation; Cerebrovascular Disorders; Cytokines; Encephalitis; | 2008 |
Brain metabolism during a decrease in cerebral perfusion pressure caused by an elevated intracranial pressure in the porcine neocortex.
Topics: Animals; Brain Ischemia; Cerebrovascular Circulation; Disease Models, Animal; Glucose; Glutamic Acid | 2007 |
Nonconvulsive electrographic seizures after traumatic brain injury result in a delayed, prolonged increase in intracranial pressure and metabolic crisis.
Topics: Case-Control Studies; Electroencephalography; Epilepsies, Partial; Epilepsy, Generalized; Epilepsy, | 2007 |
Cerebral glutamine concentration and lactate-pyruvate ratio in patients with acute liver failure.
Topics: Adolescent; Adult; Aged; Astrocytes; Brain; Brain Edema; Critical Care; Female; Glutamine; Humans; H | 2008 |
Metabolic failure precedes intracranial pressure rises in traumatic brain injury: a microdialysis study.
Topics: Biomarkers; Brain; Brain Injuries; Glutamic Acid; Glycerol; Humans; Intracranial Hypertension; Lacti | 2008 |
Brain lactate by magnetic resonance spectroscopy during fulminant hepatic failure in the dog.
Topics: Animals; Biomarkers; Brain; Dogs; Dose-Response Relationship, Drug; Feasibility Studies; Galactosami | 1998 |
Comparison of brain tissue oxygen tension to microdialysis-based measures of cerebral ischemia in fatally head-injured humans.
Topics: Adult; Brain; Brain Death; Brain Injuries; Cations; Chromatography, High Pressure Liquid; Excitatory | 1998 |
Secondary neurologic injury resulting from nonhypotensive hemorrhage combined with mild traumatic brain injury.
Topics: Animals; Blood Glucose; Brain Hemorrhage, Traumatic; Brain Injuries; Female; Hypotension; Intracrani | 1999 |
Relationship between brain temperature, brain chemistry and oxygen delivery after severe human head injury: the effect of mild hypothermia.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Body Temperature; Brain; Brain Chemistry; Brain Injuries; Ca | 2002 |