lactic acid has been researched along with Intervertebral Disc Degeneration in 16 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Intervertebral Disc Degeneration: Degenerative changes in the INTERVERTEBRAL DISC due to aging or structural damage, especially to the vertebral end-plates.
| Excerpt | Relevance | Reference |
|---|---|---|
| "During intervertebral disc degeneration (IVDD), due to endplate calcification, diminished oxygen and nutrient concentrations and accumulated lactate are present in the microenvironment of the nucleus pulposus (NP)." | 1.72 | Monocarboxylate transporter 1-mediated lactate accumulation promotes nucleus pulposus degeneration under hypoxia in a 3D multilayered nucleus pulposus degeneration model. ( Bit, A; Hsieh, MK; Hu, YJ; Lai, PL; Wang, CY, 2022) |
| "Intervertebral disc degeneration contributes to low back pain." | 1.62 | Lactate oxidative phosphorylation by annulus fibrosus cells: evidence for lactate-dependent metabolic symbiosis in intervertebral discs. ( Couch, B; Han, C; Hartman, R; Jurczak, MJ; Kang, J; Lee, J; Malkamaki, M; Mullett, SJ; Roginskaya, V; Sowa, G; Van Houten, B; Vo, N; Wang, D; Wendell, SG; Zhou, CM, 2021) |
| "However, disc degeneration was found and gradually worsened in AL group after surgery." | 1.51 | Increased lactic acid content associated with extracellular matrix depletion in a porcine disc degeneration induced by superficial annular lesion. ( Kurra, S; Niu, J; Shi, J; Wang, Z; Yang, H; Zhou, X, 2019) |
| "The rabbit annular defect model of disc degeneration appears suitable to investigate the effects of nerve ingrowth in relation to pain generation." | 1.46 | Effects of annulus defects and implantation of poly(lactic-co-glycolic acid) (PLGA)/fibrin gel scaffolds on nerves ingrowth in a rabbit model of annular injury disc degeneration. ( Fan, S; Wang, W; Wang, Z; Xin, L; Xu, W; Yu, F; Yu, L, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (6.25) | 29.6817 |
| 2010's | 12 (75.00) | 24.3611 |
| 2020's | 3 (18.75) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, CY | 1 |
| Hsieh, MK | 1 |
| Hu, YJ | 1 |
| Bit, A | 1 |
| Lai, PL | 1 |
| Pushpa, BT | 1 |
| Rajasekaran, S | 1 |
| Easwaran, M | 1 |
| Murugan, C | 1 |
| Algeri, R | 1 |
| Sri Vijay Anand, KS | 1 |
| Mugesh Kanna, R | 1 |
| Shetty, AP | 1 |
| Shi, J | 1 |
| Zhou, X | 1 |
| Wang, Z | 3 |
| Kurra, S | 1 |
| Niu, J | 1 |
| Yang, H | 1 |
| Wang, D | 1 |
| Hartman, R | 1 |
| Han, C | 1 |
| Zhou, CM | 1 |
| Couch, B | 1 |
| Malkamaki, M | 1 |
| Roginskaya, V | 1 |
| Van Houten, B | 1 |
| Mullett, SJ | 1 |
| Wendell, SG | 1 |
| Jurczak, MJ | 1 |
| Kang, J | 1 |
| Lee, J | 1 |
| Sowa, G | 1 |
| Vo, N | 1 |
| Xin, L | 2 |
| Xu, W | 1 |
| Yu, L | 1 |
| Fan, S | 2 |
| Wang, W | 2 |
| Yu, F | 1 |
| Wang, YF | 1 |
| Levene, HB | 1 |
| Gu, W | 1 |
| Huang, C-C | 1 |
| Shen, J | 1 |
| Zhuo, N | 1 |
| Xu, S | 1 |
| Song, Z | 1 |
| Hu, Z | 1 |
| Hao, J | 1 |
| Guo, X | 1 |
| Byvaltsev, VA | 1 |
| Kolesnikov, SI | 1 |
| Bardonova, LA | 1 |
| Belykh, EG | 1 |
| Korytov, LI | 1 |
| Giers, MB | 1 |
| Preul, MC | 1 |
| Wu, W | 1 |
| Zhang, X | 1 |
| Hu, X | 1 |
| Wang, X | 1 |
| Sun, L | 1 |
| Zheng, X | 1 |
| Jiang, L | 1 |
| Ni, X | 1 |
| Xu, C | 1 |
| Tian, N | 1 |
| Zhu, S | 1 |
| Xu, H | 1 |
| Yan, J | 1 |
| Yang, S | 1 |
| Sun, H | 1 |
| Guo, D | 1 |
| Wu, B | 1 |
| Ji, F | 1 |
| Zhou, D | 1 |
| Zhang, C | 1 |
| Zhong, F | 1 |
| Zhang, H | 1 |
| Wang, L | 1 |
| Park, JB | 1 |
| Park, P | 1 |
| Yang, VC | 1 |
| Hollister, SJ | 1 |
| La Marca, F | 1 |
| Lin, CY | 1 |
| Malandrino, A | 1 |
| Noailly, J | 1 |
| Lacroix, D | 1 |
| Galbusera, F | 1 |
| Mietsch, A | 1 |
| Schmidt, H | 1 |
| Wilke, HJ | 1 |
| Neidlinger-Wilke, C | 1 |
| Huang, CY | 1 |
| Travascio, F | 1 |
| Gu, WY | 1 |
| Gorth, DJ | 1 |
| Mauck, RL | 1 |
| Chiaro, JA | 1 |
| Mohanraj, B | 1 |
| Hebela, NM | 1 |
| Dodge, GR | 1 |
| Elliott, DM | 1 |
| Smith, LJ | 1 |
16 other studies available for lactic acid and Intervertebral Disc Degeneration
| Article | Year |
|---|---|
Monocarboxylate transporter 1-mediated lactate accumulation promotes nucleus pulposus degeneration under hypoxia in a 3D multilayered nucleus pulposus degeneration model.
Topics: Glycosaminoglycans; Humans; Hypoxia; Intervertebral Disc Degeneration; Lactic Acid; Matrix Metallopr | 2022 |
ISSLS PRIZE in basic science 2023: Lactate in lumbar discs-metabolic waste or energy biofuel? Insights from in vivo MRS and T2r analysis following exercise and nimodipine in healthy volunteers.
Topics: Awards and Prizes; Biofuels; Healthy Volunteers; Humans; Intervertebral Disc; Intervertebral Disc De | 2023 |
Increased lactic acid content associated with extracellular matrix depletion in a porcine disc degeneration induced by superficial annular lesion.
Topics: Animals; Disease Models, Animal; Extracellular Matrix; Female; Intervertebral Disc; Intervertebral D | 2019 |
Lactate oxidative phosphorylation by annulus fibrosus cells: evidence for lactate-dependent metabolic symbiosis in intervertebral discs.
Topics: Animals; Annulus Fibrosus; Intervertebral Disc; Intervertebral Disc Degeneration; Lactic Acid; Oxida | 2021 |
Effects of annulus defects and implantation of poly(lactic-co-glycolic acid) (PLGA)/fibrin gel scaffolds on nerves ingrowth in a rabbit model of annular injury disc degeneration.
Topics: Animals; Disease Models, Animal; Fibrin; Gels; Intervertebral Disc Degeneration; Lactic Acid; Polygl | 2017 |
Enhancement of Energy Production of the Intervertebral Disc by the Implantation of Polyurethane Mass Transfer Devices.
Topics: Animals; Biological Transport, Active; Energy Metabolism; Female; Implants, Experimental; Interverte | 2017 |
Resveratrol delivery by ultrasound-mediated nanobubbles targeting nucleus pulposus cells.
Topics: Animals; Biomarkers; Drug Delivery Systems; Emulsions; Humans; Intervertebral Disc Degeneration; Lac | 2018 |
Assessment of Lactate Production and Proteoglycans Synthesis by the Intact and Degenerated Intervertebral Disc Cells under the Influence of Activated Macrophages: an In Vitro Study.
Topics: Cell Line; Coculture Techniques; Humans; Intervertebral Disc Degeneration; Lactic Acid; Macrophages; | 2018 |
Lactate down-regulates matrix systhesis and promotes apoptosis and autophagy in rat nucleus pulposus cells.
Topics: Animals; Apoptosis; Autophagy; Cell Proliferation; Cell Survival; Down-Regulation; Female; Glycosami | 2014 |
Effects of releasing recombinant human growth and differentiation factor-5 from poly(lactic-co-glycolic acid) microspheres for repair of the rat degenerated intervertebral disc.
Topics: Aggrecans; Animals; Biocompatible Materials; Collagen; Delayed-Action Preparations; Disease Models, | 2014 |
Minimal invasive annulotomy for induction of disc degeneration and implantation of poly (lactic-co-glycolic acid) (PLGA) plugs for annular repair in a rabbit model.
Topics: Aggrecans; Animals; Biocompatible Materials; Collagen Type I; Collagen Type II; Disease Models, Anim | 2016 |
Intradiscal injection of simvastatin retards progression of intervertebral disc degeneration induced by stab injury.
Topics: Animals; Bone Morphogenetic Protein 2; Drug Carriers; Gels; Gene Expression; Hydroxymethylglutaryl-C | 2009 |
The effect of sustained compression on oxygen metabolic transport in the intervertebral disc decreases with degenerative changes.
Topics: Biological Transport; Biomechanical Phenomena; Computer Simulation; Diffusion; Finite Element Analys | 2011 |
Effect of intervertebral disc degeneration on disc cell viability: a numerical investigation.
Topics: Glucose; Humans; Intervertebral Disc Degeneration; Lactic Acid; Models, Anatomic; Oxygen | 2013 |
Quantitative analysis of exogenous IGF-1 administration of intervertebral disc through intradiscal injection.
Topics: Biomechanical Phenomena; Finite Element Analysis; Glucose; Humans; Hydrogen-Ion Concentration; Injec | 2012 |
IL-1ra delivered from poly(lactic-co-glycolic acid) microspheres attenuates IL-1β-mediated degradation of nucleus pulposus in vitro.
Topics: Cells, Cultured; Drug Delivery Systems; Humans; Interleukin 1 Receptor Antagonist Protein; Interleuk | 2012 |