lactic acid has been researched along with Intellectual Disability in 13 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Intellectual Disability: Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual has an intellectual disability. IQ scores between 70 and 79 are in the borderline range. Scores below 67 are in the disabled range. (from Joynt, Clinical Neurology, 1992, Ch55, p28)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Biochemically, beta-ketothiolase deficiency is characterized by intermittent ketoacidosis and urinary excretion of 2-methyl-acetoacetate (MAA), 2-methyl-3-hydroxybutyrate (MHB) and tiglylglycine (TG), whereas in MHBD deficiency only MHB and tiglylglycine accumulate." | 3.73 | Inhibition of energy metabolism by 2-methylacetoacetate and 2-methyl-3-hydroxybutyrate in cerebral cortex of developing rats. ( da C Ferreira, G; Dalcin, KB; de Assis, DR; Filho, CS; Latini, A; Leipnitz, G; Maria, RC; Perry, ML; Ribeiro, CA; Rosa, RB; Schuck, PF; Wajner, M; Wannmacher, CM; Wyse, AT, 2005) |
| "Propionic acidemia is the result of a deficiency in propionyl-CoA carboxylase activity." | 1.48 | Autism spectrum disorders in propionic acidemia patients. ( Arnoux, JB; Barbier, V; Bonnefont, JP; Brassier, A; Canouï, P; de la Bâtie, CD; De Lonlay, P; Gobin, S; Guemann, AS; Habarou, F; Lacaille, F; Ottolenghi, C; Ouss, L; Pontoizeau, C; Roda, C; Valayannopoulos, V, 2018) |
| "Epilepsy was present in 19 patients." | 1.33 | Mitochondrial dysfunction in autism spectrum disorders: a population-based study. ( Ataíde, A; Borges, L; Diogo, L; Garcia, P; Grazina, M; Marques, C; Miguel, T; Oliveira, CR; Oliveira, G; Vicente, AM, 2005) |
| "At age 3(1/2) years she has profound mental retardation, spasticity, and grand mal and myoclonic seizures only partially controlled by anticonvulsants." | 1.30 | Treatment of pyruvate carboxylase deficiency with high doses of citrate and aspartate. ( Ahmad, A; Artigas-Lopez, M; Kahler, SG; Kishnani, PS; Millington, DS; Pappu, AS; Steiner, R; Van Hove, JL, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (38.46) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 4 (30.77) | 29.6817 |
| 2010's | 3 (23.08) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| de la Bâtie, CD | 1 |
| Barbier, V | 1 |
| Roda, C | 1 |
| Brassier, A | 1 |
| Arnoux, JB | 1 |
| Valayannopoulos, V | 1 |
| Guemann, AS | 1 |
| Pontoizeau, C | 1 |
| Gobin, S | 1 |
| Habarou, F | 1 |
| Lacaille, F | 1 |
| Bonnefont, JP | 1 |
| Canouï, P | 1 |
| Ottolenghi, C | 1 |
| De Lonlay, P | 1 |
| Ouss, L | 1 |
| Vissing, J | 1 |
| Akman, HO | 1 |
| Aasly, J | 1 |
| Kahler, SG | 2 |
| Bacino, CA | 1 |
| DiMauro, S | 1 |
| Haller, RG | 1 |
| Cassandrini, D | 1 |
| Cilio, MR | 1 |
| Bianchi, M | 1 |
| Doimo, M | 1 |
| Balestri, M | 1 |
| Tessa, A | 1 |
| Rizza, T | 1 |
| Sartori, G | 1 |
| Meschini, MC | 1 |
| Nesti, C | 1 |
| Tozzi, G | 1 |
| Petruzzella, V | 1 |
| Piemonte, F | 1 |
| Bisceglia, L | 1 |
| Bruno, C | 1 |
| Dionisi-Vici, C | 1 |
| D'Amico, A | 1 |
| Fattori, F | 1 |
| Carrozzo, R | 1 |
| Salviati, L | 1 |
| Santorelli, FM | 1 |
| Bertini, E | 1 |
| ISRAELS, S | 1 |
| HAWORTH, JC | 1 |
| GOURLEY, B | 1 |
| FORD, JD | 1 |
| Overweg-Plandsoen, WC | 1 |
| Groener, JE | 1 |
| Wang, D | 1 |
| Onkenhout, W | 1 |
| Brouwer, OF | 1 |
| Bakker, HD | 1 |
| De Vivo, DC | 1 |
| PRESCOTT, BA | 1 |
| BOREK, E | 1 |
| Oliveira, G | 1 |
| Diogo, L | 1 |
| Grazina, M | 1 |
| Garcia, P | 1 |
| Ataíde, A | 1 |
| Marques, C | 1 |
| Miguel, T | 1 |
| Borges, L | 1 |
| Vicente, AM | 1 |
| Oliveira, CR | 1 |
| Rosa, RB | 1 |
| Schuck, PF | 1 |
| de Assis, DR | 1 |
| Latini, A | 1 |
| Dalcin, KB | 1 |
| Ribeiro, CA | 1 |
| da C Ferreira, G | 1 |
| Maria, RC | 1 |
| Leipnitz, G | 1 |
| Perry, ML | 1 |
| Filho, CS | 1 |
| Wyse, AT | 1 |
| Wannmacher, CM | 1 |
| Wajner, M | 1 |
| Cheung, PY | 1 |
| Chui, N | 1 |
| Joffe, AR | 1 |
| Rebeyka, IM | 1 |
| Robertson, CM | 1 |
| Tsuchiyama, A | 1 |
| Oyanagi, K | 1 |
| Sogawa, H | 1 |
| Nakao, T | 1 |
| Ogawa, K | 1 |
| Fujita, S | 1 |
| Ahmad, A | 1 |
| Kishnani, PS | 1 |
| Artigas-Lopez, M | 1 |
| Pappu, AS | 1 |
| Steiner, R | 1 |
| Millington, DS | 1 |
| Van Hove, JL | 1 |
| Haas, RH | 1 |
| Rice, MA | 1 |
| Trauner, DA | 1 |
| Merritt, TA | 1 |
| Kobayashi, M | 1 |
| Morishita, H | 1 |
| Sugiyama, N | 1 |
| Yokochi, K | 1 |
| Nakano, M | 1 |
| Wada, Y | 1 |
| Hotta, Y | 1 |
| Terauchi, A | 1 |
| Nonaka, I | 1 |
13 other studies available for lactic acid and Intellectual Disability
| Article | Year |
|---|---|
Autism spectrum disorders in propionic acidemia patients.
Topics: Adolescent; Adult; Autism Spectrum Disorder; Child; Child, Preschool; Female; Humans; Intellectual D | 2018 |
Level of residual enzyme activity modulates the phenotype in phosphoglycerate kinase deficiency.
Topics: Ergometry; Exercise Test; Exercise Tolerance; Genetic Diseases, X-Linked; Humans; Intellectual Disab | 2018 |
Pontocerebellar hypoplasia type 6 caused by mutations in RARS2: definition of the clinical spectrum and molecular findings in five patients.
Topics: Arginine-tRNA Ligase; Cerebellum; Child, Preschool; Female; Follow-Up Studies; Humans; Infant; Infan | 2013 |
CHRONIC ACIDOSIS DUE TO AN ERROR IN LACTATE AND PYRUVATE METABOLISM. REPORT OF TWO CASES.
Topics: Acetoacetates; Acidosis; Blood; Blood Gas Analysis; Carbohydrate Metabolism; Carbohydrate Metabolism | 1964 |
GLUT-1 deficiency without epilepsy--an exceptional case.
Topics: Ataxia; Blood Glucose; Carbohydrate Metabolism, Inborn Errors; Child; DNA; DNA Mutational Analysis; | 2003 |
Studies on oligophrenia phenylpyruvica; microbiological determination of L- and D-phenylalanine and of phenyl lactic acid.
Topics: Acids; Body Fluids; Intellectual Disability; Lactic Acid; Phenylalanine; Phenylketonurias; Urine | 1949 |
Mitochondrial dysfunction in autism spectrum disorders: a population-based study.
Topics: Adolescent; Autistic Disorder; Child; Comorbidity; Cross-Sectional Studies; Epilepsy; Female; Humans | 2005 |
Inhibition of energy metabolism by 2-methylacetoacetate and 2-methyl-3-hydroxybutyrate in cerebral cortex of developing rats.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Acetates; Acetoacetates; Acetyl-CoA C-Acyltransferase; Acidosis; A | 2005 |
Postoperative lactate concentrations predict the outcome of infants aged 6 weeks or less after intracardiac surgery: a cohort follow-up to 18 months.
Topics: Biomarkers; Blindness; Cardiac Surgical Procedures; Cerebral Palsy; Child Development; Cohort Studie | 2005 |
Normal activities of hepatic pyruvate dehydrogenase and pyruvate carboxylase in Leigh's syndrome.
Topics: Brain; Brain Stem; Central Nervous System Diseases; Encephalomalacia; Humans; Infant; Intellectual D | 1983 |
Treatment of pyruvate carboxylase deficiency with high doses of citrate and aspartate.
Topics: Amino Acids; Aspartic Acid; Child, Preschool; Citric Acid; Dose-Response Relationship, Drug; Female; | 1999 |
Therapeutic effects of a ketogenic diet in Rett syndrome.
Topics: Ammonia; Blood Glucose; Child; Child, Preschool; Dietary Fats; Electroencephalography; Energy Intake | 1986 |
Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes syndrome and NADH-CoQ reductase deficiency.
Topics: Acidosis; Adolescent; Cerebrovascular Disorders; Child, Preschool; Humans; Intellectual Disability; | 1986 |