lactic acid and Innate Inflammatory Response studies

Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.

Research Excerpts

Excerpt	Relevance	Reference
"This study aimed to investigate the effects of Ginsenoside Rh4 (Rh4) on inflammation-related hepatocellular carcinoma (HCC) progression and the underlying mechanism."	8.31	Ginsenoside Rh4 inhibits inflammation-related hepatocellular carcinoma progression by targeting HDAC4/IL-6/STAT3 signaling. ( Jiang, R; Jiang, X; Luo, S; Qiu, Q; Wang, W; Wu, Y; Yuan, Y; Zhang, M; Zhuo, S, 2023)
"We measured concentrations of kynurenine (Kyn) and tryptophan (Trp) in 221 cerebrospinal fluid samples from patients with bacterial and viral (due to herpes simplex, varicella zoster, and enteroviruses) meningitis/encephalitis, neuroborreliosis, autoimmune neuroinflammation (due to anti-N-methyl-D-aspartate receptor [NMDA] encephalitis and multiple sclerosis), and noninflamed controls (ie, individuals with Bell palsy, normal pressure hydrocephalus, or Tourette syndrome)."	7.91	Kynurenine Is a Cerebrospinal Fluid Biomarker for Bacterial and Viral Central Nervous System Infections. ( Kaever, V; Kuhn, M; Müller-Vahl, K; Novoselova, N; Pessler, F; Seegers, L; Skripuletz, T; Stangel, M; Sühs, KW; Trebst, C, 2019)
"Phytic acid (PA) has been demonstrated to have a potent anticarcinogenic activity against colorectal cancer (CRC)."	7.88	Phytic acid improves intestinal mucosal barrier damage and reduces serum levels of proinflammatory cytokines in a 1,2-dimethylhydrazine-induced rat colorectal cancer model. ( Chen, C; Cheng, L; Li, X; Liu, C; Song, Y; Yang, F, 2018)
"To study the effect of novel bioresorbable scaffold composed of poly-L-lactic acid (PLLA) and amorphous calcium phosphate (ACP) nanoparticles on inflammation and calcification of surrounding tissues after implantation."	7.88	Effect of novel bioresorbable scaffold composed of poly-L-lactic acid and amorphous calcium phosphate nanoparticles on inflammation and calcification of surrounding tissues after implantation. ( Chen, J; Chen, T; Chen, X; Feng, G; Jiang, X; Qin, C; Xia, J; Yi, X, 2018)
"To develop thalidomide-loaded poly-lactide-co-glycolide implants and evaluate its in vivo release and biological activity against inflammation and angiogenesis after subcutaneous administration."	7.81	Development of thalidomide-loaded biodegradable devices and evaluation of the effect on inhibition of inflammation and angiogenesis after subcutaneous application. ( Andrade, SP; Batista, LF; da Nova Mussel, W; da Silva, GR; de Souza, PA; Fialho, SL; Pereira, BG; Serakides, R; Silva-Cunha, A, 2015)
" Inflammation and coagulation are closely associated pathological processes, therefore the potential effects of metformin on key steps in activation of the coagulation system were further investigated in endotoxic hepatitis induced by lipopolysaccharide/D‑galactosamine (LPS/D‑Gal)."	7.81	Metformin suppresses intrahepatic coagulation activation in mice with lipopolysaccharide/D‑galactosamine‑induced fulminant hepatitis. ( Ai, Q; Ao, JE; Duan, R; Ge, P; Gong, X; Lin, L; Zhang, L, 2015)
" Pathological metabolic shift and subsequent lactic acid production are thought to play an important role in diverse painful states; however, their contribution to inflammation-driven pain is still to be comprehended."	7.81	Metabolic Connection of Inflammatory Pain: Pivotal Role of a Pyruvate Dehydrogenase Kinase-Pyruvate Dehydrogenase-Lactic Acid Axis. ( Go, Y; Harris, RA; Jeoung, NH; Jha, MK; Kook, H; Lee, IK; Lee, MG; Park, DH; Song, GJ; Suk, K, 2015)
" In this study, we have evaluated anti-asthmatic efficacy of inhalable montelukast-loaded large porous particulate formulations in ovalbumin-induced rat airway inflammation model that mimics asthma."	7.80	Aerosolized montelukast polymeric particles-an alternative to oral montelukast-alleviate symptoms of asthma in a rodent model. ( Ahsan, F; Gupta, N; Patel, B, 2014)
" Celecoxib (CXB), a selective COX-2 inhibitor, is able to control inflammation and pain, to improve the efficacy of radiotherapy, and to inhibit at high doses the growth of cancer cells."	7.80	New celecoxib multiparticulate systems to improve glioblastoma treatment. ( Barcia, E; Fernández-Carballido, A; García-García, L; Marcianes, P; Negro, S; Slowing, K; Vera, M, 2014)
" The aim of the present study was to examine the impact of a novel NHE1 inhibitor, sabiporide, on cardiovascular function, blood oxygen transportation, and inflammatory response in an experimental model of metabolic acidosis produced by hemorrhage-induced hypovolemia followed by an infusion of lactic acid."	7.79	Sabiporide improves cardiovascular function, decreases the inflammatory response and reduces mortality in acute metabolic acidosis in pigs. ( Abraham, WM; Kraut, JA; Wu, D, 2013)
"Polylactic acid (PLA) patch has proper steric configuration, sufficient mechanic strength, and flexibility, to investigate the blocking effect on the intra-discal inflammation after annulus puncture sticked by medical glue so as to seal the pinhole left after annulus puncture."	7.76	[A study on blocking effect of polylactic acid patch on intra-discal inflammation after annulus puncture]. ( Feng, G; Gong, Q; Huang, X; Li, T; Liu, H; Liu, L; Liu, X; Shi, R; Song, Y; Zhang, W; Zhao, X, 2010)
"In this study, we report protective effects of dietary L-arginine (L-Arg) supplementation against oxidative stress and inflammation in aging rats during exhaustive exercise."	7.74	Potential ergogenic effects of L-arginine against oxidative and inflammatory stress induced by acute exercise in aging rats. ( Huang, CC; Lin, WT; Tsai, SC, 2008)
"Sepsis is a complex disorder with very high morbidity and mortality; it can occur when an immune disorder triggers an invasion of pathogens in the host."	5.56	Inflammation-targeting polymeric nanoparticles deliver sparfloxacin and tacrolimus for combating acute lung sepsis. ( Ding, Y; Fan, B; Mao, Z; Wang, W; Wang, Y; Wu, J; Yang, Y, 2020)
"Ischemia was followed by a significant increase in muscle myeloperoxidase activity, as well as interleukin-6 and thiobarbituric acid reactive substances species levels."	5.48	N-acetylcysteine effects on a murine model of chronic critical limb ischemia. ( Constantino, L; da Silva, LA; Dal-Pizzol, F; Dall'Igna, DM; de Medeiros, WA; Dos Santos Cardoso, J; Manfredini, A; Michels, M; Ritter, C; Scaini, G; Streck, EL; Vuolo, F, 2018)
"Lactic acid bacteria treatment reduced CXCL8 and IL1B expression 4."	5.46	A combination of lactic acid bacteria regulates Escherichia coli infection and inflammation of the bovine endometrium. ( Arís, A; Bach, À; Fàbregas, F; Genís, S; Sánchez-Chardi, A, 2017)
" We conclude that NQC with greater bioavailability offers significantly higher potency in downregulating MMP-9 and NOS-2 as well as oxidative stress in blocking ethanol-induced gastric ulcer."	5.38	The use of nano-quercetin to arrest mitochondrial damage and MMP-9 upregulation during prevention of gastric inflammation induced by ethanol in rat. ( Chakraborty, S; Choudhury, ST; Das, N; Ghosh, S; Stalin, S; Swarnakar, S, 2012)
"However, meningitis-induced CSF leukocytosis at 4 h and increased CSF lactate and tumor necrosis factor alpha levels were not significantly attenuated."	5.31	7-Nitroindazole, but not aminoguanidine, attenuates the acute inflammatory responses and brain injury during the early phase of Escherichia coli meningitis in the newborn piglet. ( Chang, YS; Lee, M; Park, WS, 2001)
"We employed the 'delayed onset of muscle soreness' (DOMS) and the 'hypertonic saline' muscle pain models in combination with muscle microdialysis to evaluate the role of potentially algesic substances (lactate, glutamate, prostaglandin E2 (PGE2), nitric oxide (NO) and substance P (SP)) in the development of human muscle pain."	5.10	Release of algesic substances in human experimental muscle pain. ( Geisslinger, G; Meller, ST; Tegeder, L; Zimmermann, J, 2002)
"This study aimed to investigate the effects of Ginsenoside Rh4 (Rh4) on inflammation-related hepatocellular carcinoma (HCC) progression and the underlying mechanism."	4.31	Ginsenoside Rh4 inhibits inflammation-related hepatocellular carcinoma progression by targeting HDAC4/IL-6/STAT3 signaling. ( Jiang, R; Jiang, X; Luo, S; Qiu, Q; Wang, W; Wu, Y; Yuan, Y; Zhang, M; Zhuo, S, 2023)
" The present study is aimed at testing the hypothesis that resistant maltodextrin (RM), a soluble dietary fiber produced by starch debranching, alleviated dextran sulfate sodium- (DSS-) induced colitis in mice."	3.96	Resistant Maltodextrin Alleviates Dextran Sulfate Sodium-Induced Intestinal Inflammatory Injury by Increasing Butyric Acid to Inhibit Proinflammatory Cytokine Levels. ( Han, D; Huang, S; Pang, J; Wang, J; Wang, S; Wu, Y; Wu, Z; Zhang, S, 2020)
"We measured concentrations of kynurenine (Kyn) and tryptophan (Trp) in 221 cerebrospinal fluid samples from patients with bacterial and viral (due to herpes simplex, varicella zoster, and enteroviruses) meningitis/encephalitis, neuroborreliosis, autoimmune neuroinflammation (due to anti-N-methyl-D-aspartate receptor [NMDA] encephalitis and multiple sclerosis), and noninflamed controls (ie, individuals with Bell palsy, normal pressure hydrocephalus, or Tourette syndrome)."	3.91	Kynurenine Is a Cerebrospinal Fluid Biomarker for Bacterial and Viral Central Nervous System Infections. ( Kaever, V; Kuhn, M; Müller-Vahl, K; Novoselova, N; Pessler, F; Seegers, L; Skripuletz, T; Stangel, M; Sühs, KW; Trebst, C, 2019)
" The purpose of this study was to better understand the effect of inflammation on cerebral subcellular energetics in animals exposed to two different anesthetic agents-a GABA agonist (propofol) and a volatile agent (isoflurane)."	3.91	Impact of inflammation on brain subcellular energetics in anesthetized rats. ( Ikeda, K; Osuru, HP; Paila, U; Thiele, RH; Zuo, Z, 2019)
"Phytic acid (PA) has been demonstrated to have a potent anticarcinogenic activity against colorectal cancer (CRC)."	3.88	Phytic acid improves intestinal mucosal barrier damage and reduces serum levels of proinflammatory cytokines in a 1,2-dimethylhydrazine-induced rat colorectal cancer model. ( Chen, C; Cheng, L; Li, X; Liu, C; Song, Y; Yang, F, 2018)
"To study the effect of novel bioresorbable scaffold composed of poly-L-lactic acid (PLLA) and amorphous calcium phosphate (ACP) nanoparticles on inflammation and calcification of surrounding tissues after implantation."	3.88	Effect of novel bioresorbable scaffold composed of poly-L-lactic acid and amorphous calcium phosphate nanoparticles on inflammation and calcification of surrounding tissues after implantation. ( Chen, J; Chen, T; Chen, X; Feng, G; Jiang, X; Qin, C; Xia, J; Yi, X, 2018)
"The PCMN provided a sustained release of capsaicin in vitro and inhibited carrageenan-induced inflammatory pain in mouse model in vivo."	3.85	Preparation and Evaluation of PLGA-Coated Capsaicin Magnetic Nanoparticles. ( Arulsamy, N; Baskaran, M; Baskaran, P; Thyagarajan, B, 2017)
" Noteworthy, oxamate and galloflavin, two inhibitors of LDH activity which reduce lactate production in cells, were found to relieve the inflammation-induced effects."	3.85	Lactate dehydrogenase inhibitors can reverse inflammation induced changes in colon cancer cells. ( Di Ianni, L; Di Stefano, G; Govoni, M; Manerba, M; Recanatini, M; Roberti, M, 2017)
" The goal of this study was to encapsulate Aspirin-Triggered Resolvin D1 (AT-RvD1) into a degradable biomaterial in order to elucidate the effects of sustained, localized delivery in a model of sterile inflammation."	3.85	Aspirin-Triggered Resolvin D1-modified materials promote the accumulation of pro-regenerative immune cell subsets and enhance vascular remodeling. ( Botchwey, EA; Olingy, CE; San Emeterio, CL; Sok, MCP; Tria, MC, 2017)
"To develop thalidomide-loaded poly-lactide-co-glycolide implants and evaluate its in vivo release and biological activity against inflammation and angiogenesis after subcutaneous administration."	3.81	Development of thalidomide-loaded biodegradable devices and evaluation of the effect on inhibition of inflammation and angiogenesis after subcutaneous application. ( Andrade, SP; Batista, LF; da Nova Mussel, W; da Silva, GR; de Souza, PA; Fialho, SL; Pereira, BG; Serakides, R; Silva-Cunha, A, 2015)
" Inflammation and coagulation are closely associated pathological processes, therefore the potential effects of metformin on key steps in activation of the coagulation system were further investigated in endotoxic hepatitis induced by lipopolysaccharide/D‑galactosamine (LPS/D‑Gal)."	3.81	Metformin suppresses intrahepatic coagulation activation in mice with lipopolysaccharide/D‑galactosamine‑induced fulminant hepatitis. ( Ai, Q; Ao, JE; Duan, R; Ge, P; Gong, X; Lin, L; Zhang, L, 2015)
" Pathological metabolic shift and subsequent lactic acid production are thought to play an important role in diverse painful states; however, their contribution to inflammation-driven pain is still to be comprehended."	3.81	Metabolic Connection of Inflammatory Pain: Pivotal Role of a Pyruvate Dehydrogenase Kinase-Pyruvate Dehydrogenase-Lactic Acid Axis. ( Go, Y; Harris, RA; Jeoung, NH; Jha, MK; Kook, H; Lee, IK; Lee, MG; Park, DH; Song, GJ; Suk, K, 2015)
" In this study, we have evaluated anti-asthmatic efficacy of inhalable montelukast-loaded large porous particulate formulations in ovalbumin-induced rat airway inflammation model that mimics asthma."	3.80	Aerosolized montelukast polymeric particles-an alternative to oral montelukast-alleviate symptoms of asthma in a rodent model. ( Ahsan, F; Gupta, N; Patel, B, 2014)
" Celecoxib (CXB), a selective COX-2 inhibitor, is able to control inflammation and pain, to improve the efficacy of radiotherapy, and to inhibit at high doses the growth of cancer cells."	3.80	New celecoxib multiparticulate systems to improve glioblastoma treatment. ( Barcia, E; Fernández-Carballido, A; García-García, L; Marcianes, P; Negro, S; Slowing, K; Vera, M, 2014)
" Compared to normal controls, untreated burned animals showed decreased hemodynamic parameters, increased serum lactic acid, and severe myocardial inflammation."	3.79	Shaking stress aggravates burn-induced cardiovascular and renal disturbances in a rabbit model. ( Chen, YS; Hu, JY; Huang, YS; Lei, ZY; Luo, ZH; Ruan, J; Wang, G; Xiao, R; Zhang, BQ; Zhang, JP, 2013)
" The aim of the present study was to examine the impact of a novel NHE1 inhibitor, sabiporide, on cardiovascular function, blood oxygen transportation, and inflammatory response in an experimental model of metabolic acidosis produced by hemorrhage-induced hypovolemia followed by an infusion of lactic acid."	3.79	Sabiporide improves cardiovascular function, decreases the inflammatory response and reduces mortality in acute metabolic acidosis in pigs. ( Abraham, WM; Kraut, JA; Wu, D, 2013)
" In both groups, blood samples were collected from the right superior pulmonary vein, and inflammation and oxidative stress markers (malondialdehyde, lactic acid, platelet-activating factor, and myeloperoxidase) were studied."	3.77	Does on-pump normothermic beating-heart valve surgery with low tidal volume ventilation protect the lungs? ( Altinay, L; Babaroglu, S; Cicekcioglu, F; Katircioglu, SF; Mungan, U; Parlar, AI; Saydam, GS; Topcu, DI; Tütün, U; Yay, K, 2011)
"Polylactic acid (PLA) patch has proper steric configuration, sufficient mechanic strength, and flexibility, to investigate the blocking effect on the intra-discal inflammation after annulus puncture sticked by medical glue so as to seal the pinhole left after annulus puncture."	3.76	[A study on blocking effect of polylactic acid patch on intra-discal inflammation after annulus puncture]. ( Feng, G; Gong, Q; Huang, X; Li, T; Liu, H; Liu, L; Liu, X; Shi, R; Song, Y; Zhang, W; Zhao, X, 2010)
" But polylactic acid/polyglycolic acid (PLA/PGA) fibers, the frequently used scaffolds for cartilage engineering, often elicit an obvious inflammation response following implantation into immunocompetent animals."	3.75	In vitro precultivation alleviates post-implantation inflammation and enhances development of tissue-engineered tubular cartilage. ( Cao, Y; Cen, L; Cui, L; Liu, W; Luo, X; Zhang, WJ; Zhou, G, 2009)
", samples with HMGB-1 levels >2 SD above the mean level in samples from patients with noninflammatory arthropathy), concentrations of HMGB-1 were significantly correlated with those of lactic acid, a marker of tissue hypoxia."	3.74	Extracellular high mobility group box chromosomal protein 1 is a coupling factor for hypoxia and inflammation in arthritis. ( Abeyama, K; Fukuda, T; Fukuzaki, K; Hamada, T; Hashiguchi, K; Horai, N; Komiya, S; Kuwazuru, A; Maruyama, I; Nagata, R; Nagayama, S; Sunahara, N; Tanaka, M; Torikai, M; Yamada, S, 2008)
"The aim of the present study was to evaluate the efficacy of an absorbable polylactic acid film barrier in preventing postoperative intra-abdominal adhesions, inflammation, and fibrosis in an animal model."	3.74	Effect of polylactic acid film barrier on intra-abdominal adhesion formation. ( Ersoy, E; Gundogdu, H; Ozdogan, M; Ozturk, V; Yazgan, A, 2008)
"In this study, we report protective effects of dietary L-arginine (L-Arg) supplementation against oxidative stress and inflammation in aging rats during exhaustive exercise."	3.74	Potential ergogenic effects of L-arginine against oxidative and inflammatory stress induced by acute exercise in aging rats. ( Huang, CC; Lin, WT; Tsai, SC, 2008)
" In this Review, we describe how the bioavailability of lactate differs in the microenvironments of tumours and inflammatory diseases compared with normal tissues, thus contributing to the establishment of specific immunological states in disease."	2.72	Lactate modulation of immune responses in inflammatory versus tumour microenvironments. ( Certo, M; Ho, PC; Mauro, C; Pucino, V; Tsai, CH, 2021)
"Taurine has become a popular supplement among athletes attempting to improve performance."	2.72	Taurine in sports and exercise. ( Doyle, JA; Kurtz, JA; Otis, JS; VanDusseldorp, TA, 2021)
"Inflammation is associated with the accumulation of lactate at sites of tumor-growth and inflammation."	2.58	Lactate transporters as therapeutic targets in cancer and inflammatory diseases. ( Cucchi, D; Mauro, C; Pucino, V, 2018)
"Inflammation is an important component of normal responses to infection and injury."	2.49	Metabolomics--a novel window into inflammatory disease. ( Fitzpatrick, M; Young, SP, 2013)
"We establish a mouse vascular stenosis model with intravenously injecting of PLGA NPs for 2 weeks."	1.91	Biodegradable polymeric nanoparticles increase risk of cardiovascular diseases by inducing endothelium dysfunction and inflammation. ( Du, R; Fuad, ARM; Huang, J; Li, Y; Shi, W; Wang, G; Wang, Y; Yin, T, 2023)
" In our study, patients were administered a daily dosage of 2 × 600 mg of diosmin for 3 months, and we evaluated several factors associated with oxygen management, angiogenesis, and inflammation using biochemical assays."	1.91	Effect of Diosmin on Selected Parameters of Oxygen Homeostasis. ( Dresler, S; Feldo, M; Płachno, BJ; Samborski, D; Sowa, I; Sowa, P; Wójciak, M, 2023)
"Alveolar inflammation is a hallmark of acute lung injury (ALI), and its clinical correlate is acute respiratory distress syndrome-and it is as a result of interactions between alveolar type II cells (ATII) and alveolar macrophages (AM)."	1.91	Lactate produced by alveolar type II cells suppresses inflammatory alveolar macrophages in acute lung injury. ( Allawzi, A; Burns, N; Graham, J; Nozik, ES; Roy, RM; Rubio, V; Stenmark, K; Sul, C; Tuder, RM; Vohwinkel, CU, 2023)
"Chronic inflammation is a common pathological event that is associated with aging and neurodegenerative diseases."	1.72	Chronic microglial inflammation promotes neuronal lactate supply but impairs its utilization in primary rat astrocyte-neuron co-cultures. ( Li, J; Li, ZQ; Pan, ZY; Wang, MY; Wang, Y; Wang, ZF, 2022)
"This study developed, a novel polypropylene (PP) mesh combined with poly (L-lactic acid) (PLA) electrospun nanofibers loaded sirolimus (SRL)."	1.72	Polypropylene mesh combined with electrospun poly (L-lactic acid) membrane in situ releasing sirolimus and its anti-adhesion efficiency in rat hernia repair. ( Dai, J; Hu, W; Ji, Z; Ren, P; Shao, X; Xiong, B; Zhang, T; Zhang, Z; Zhu, L, 2022)
"Cholangiocarcinoma (CCA), or cancer of bile duct epithelial cells, is a very aggressive malignancy characterized by early lymphangiogenesis in the tumor microenvironment (TME) and lymph node (LN) metastasis which correlate with adverse patient outcome."	1.62	Tumor Lymphatic Interactions Induce CXCR2-CXCL5 Axis and Alter Cellular Metabolism and Lymphangiogenic Pathways to Promote Cholangiocarcinoma. ( Alpini, G; Banerjee, P; Bayless, KJ; Chakraborty, S; Chauhan, R; Ekser, B; Glaser, SS; Kumaravel, S; O'Brien, A; Roy, S; Seelig, C; White, TK, 2021)
"Endotoxemia was induced by systemic injection of lipopolysaccharide (LPS) (1."	1.62	Central Administration of Angiotensin-(1-7) Improves Vasopressin Impairment and Hypotensive Response in Experimental Endotoxemia. ( Antunes-Rodrigues, J; Batalhão, ME; Bendhack, LM; Capellari Carnio, E; de Lima Faim, F; Lacchini, R; Passaglia, P; Stabile, AM, 2021)
"Hypoxia and inflammation are hallmarks of critical illness, related to multiple organ failure."	1.62	Systemic inflammation down-regulates glyoxalase-1 expression: an experimental study in healthy males. ( Bergmans, DCJJ; Driessen, RGH; Gerretsen, J; Kiers, D; Kox, M; Pickkers, P; Schalkwijk, CG; Scheijen, JLJM; van Bussel, BCT; van de Poll, MCG; van der Horst, ICC, 2021)
"Sixteen children and adolescents with type 1 diabetes (T1D) had blood samples obtained, 6-12 hours into treatment, at three weeks and three months post start of treatment."	1.56	Soluble Receptor for Glycation End-products Concentration Increases Following the Treatment of Severe Diabetic Ketoacidosis ( Artlett, CM; Blum, J; Hoffman, WH; Ikeda, T; Ishikawa, T; Tani, N, 2020)
"Sepsis is a complex disorder with very high morbidity and mortality; it can occur when an immune disorder triggers an invasion of pathogens in the host."	1.56	Inflammation-targeting polymeric nanoparticles deliver sparfloxacin and tacrolimus for combating acute lung sepsis. ( Ding, Y; Fan, B; Mao, Z; Wang, W; Wang, Y; Wu, J; Yang, Y, 2020)
"Inflammation is involved in many disease processes."	1.56	Lactate Production Precedes Inflammatory Cell Recruitment in Arthritic Ankles: an Imaging Study. ( Beziere, N; Bouzin, C; Comment, A; Daniels, R; Fuchs, K; Kneilling, M; Neveu, MA; Pichler, BJ; Schmid, AM; Schwenck, J, 2020)
"Sepsis is the leading cause of death in hospitalized patients and beyond the hospital stay and these long-term sequelae are due in part to unresolved inflammation."	1.56	Dichloroacetate-induced metabolic reprogramming improves lifespan in a Drosophila model of surviving sepsis. ( Angus, DC; Bakalov, V; Chang, CH; Deshpande, R; Kaynar, AM; Le Moyec, L; Maloy, AL; Reyes-Uribe, L; Shapiro, SD; Wendell, SG, 2020)
"Lactic acid (LA) is a major organic acid metabolite produced by vaginal lactobacilli that elicits anti-inflammatory effects from cervicovaginal epithelial cells and is dramatically depleted during BV."	1.51	Distinct Immune Responses Elicited From Cervicovaginal Epithelial Cells by Lactic Acid and Short Chain Fatty Acids Associated With Optimal and Non-optimal Vaginal Microbiota. ( Delgado-Diaz, DJ; Gugasyan, R; Hayward, JA; Hearps, AC; Tachedjian, G; Tyssen, D, 2019)
"Chronic inflammation is a major driving factor for the development of colitis-associated cancer (CAC)."	1.51	( Cao, G; Li, J; Li, Z; Shen, H; Xie, P; Yue, Z; Zang, T; Zhang, S; Zhu, Y, 2019)
"Metabolic syndrome is an agglomeration of disorders including obesity, diabetes and cardiovascular diseases and characterized as chronic mild inflammation which elevates the circulatory inflammatory markers."	1.51	High fat diet administration leads to the mitochondrial dysfunction and selectively alters the expression of class 1 GLUT protein in mice. ( Jha, D; Mitra Mazumder, P, 2019)
"Sepsis has a well-studied inflammatory phase, with a less-understood secondary immunosuppressive phase."	1.51	Lactic Acid Inhibits Lipopolysaccharide-Induced Mast Cell Function by Limiting Glycolysis and ATP Availability. ( Abdul Qayum, A; Abebayehu, D; Barnstein, BO; Caslin, HL; Chalfant, CE; Haque, TT; Hoeferlin, LA; Paez, PA; Pondicherry, N; Ryan, JJ; Taruselli, MT, 2019)
"Ischemia was followed by a significant increase in muscle myeloperoxidase activity, as well as interleukin-6 and thiobarbituric acid reactive substances species levels."	1.48	N-acetylcysteine effects on a murine model of chronic critical limb ischemia. ( Constantino, L; da Silva, LA; Dal-Pizzol, F; Dall'Igna, DM; de Medeiros, WA; Dos Santos Cardoso, J; Manfredini, A; Michels, M; Ritter, C; Scaini, G; Streck, EL; Vuolo, F, 2018)
"Conditions include Alzheimer's disease, atherosclerosis, diabetes mellitus, obesity, cancer, autoimmunity and psychosis, amongst others."	1.48	Optimise the microbial flora with milk and yoghurt to prevent disease. ( Morris, JA, 2018)
" The present study takes the advantages of nanocarriers combined with a ligand (galactose) anchoring to orally deliver RES in an attempt to improve its bioavailability and pharmacological activity."	1.48	Galactosylated PLGA nanoparticles for the oral delivery of resveratrol: enhanced bioavailability and in vitro anti-inflammatory activity. ( Li, S; Lin, H; Siu, FY; Ye, S, 2018)
"During the 8th week, two wounds were created in the dorsum and collected 10 days later."	1.46	Exercise prior to, but not concomitant with, stress reverses stress-induced delayed skin wound healing. ( Martins, RL; Monte-Alto-Costa, A; Romana-Souza, B; Saguie, BO, 2017)
"steatosis grade 3 or steatohepatitis with or without beginning fibrosis frequently show altered fecal microbiota composition and elevated bacterial endotoxin levels."	1.46	Markers of intestinal permeability are already altered in early stages of non-alcoholic fatty liver disease: Studies in children. ( Bergheim, I; Engstler, AJ; Maier, IB; Nier, A, 2017)
"Lactic acid bacteria treatment reduced CXCL8 and IL1B expression 4."	1.46	A combination of lactic acid bacteria regulates Escherichia coli infection and inflammation of the bovine endometrium. ( Arís, A; Bach, À; Fàbregas, F; Genís, S; Sánchez-Chardi, A, 2017)
" Impaired bioavailability of endothelial nitric oxide synthase (eNOS) is one of the main reasons of endothelial dysfunction."	1.46	mZD7349 peptide-conjugated PLGA nanoparticles directed against VCAM-1 for targeted delivery of simvastatin to restore dysfunctional HUVECs. ( Amani, A; Deiham, B; Doosti, M; Faramarzi, MA; Imanparast, F; Kobarfard, F; Paknejad, M; Vatannejad, A, 2017)
"Inflammation was evaluated by interleukin-1 beta and tumor necrosis factor alpha quantification and by a hemogram, whereas bone repair was evaluated using densitometry and scanning electron microscopy."	1.43	Analysis of Bone Repair and Inflammatory Process Caused by Simvastatin Combined With PLGA+HA+βTCP Scaffold. ( Aragonez, A; Bobinski, F; Cordeiro, MM; Corrêa, M; de Freitas, SF; dos Santos, AR; Encarnação, IC; Goldfeder, EM; Xavier, CC, 2016)
"Histological chorioamnionitis and adverse neonatal neurological outcomes were observed in nine (33%) and four (15%) cases, respectively."	1.43	Vaginal Fluid Inflammatory Biomarkers and the Risk of Adverse Neonatal Outcomes in Women with PPROM. ( Bujold, E; Demers, S; Dorfeuille, N; Gouin, K; Laforest, G; Morin, V; Piedboeuf, B; Tétu, A, 2016)
"In healthy term newborns with chorioamnionitis, MRS ratios shortly after birth may provide evidence of occult neuroinflammation, which may be associated with worse performance on 1-year neurodevelopmental tests."	1.42	Proton magnetic resonance spectroscopy and outcome in term neonates with chorioamnionitis. ( Bentzley, JP; Brown, T; Hope, K; Jenkins, DD; Johnson, CB; Katikaneni, LD; Lambert, D; Morgan, PS; Mulvihill, DM; Ramakrishnan, V; Rollins, LG, 2015)
"Different animal models of experimental lung injury have been used to investigate mechanisms of lung injury."	1.42	Time- and dose-dependent severity of lung injury in a rat model of sepsis. ( Azamfirei, L; Cioc, AD; Copotoiu, SM; Cotoi, OS; Fodor, P; Fodor, RŞ; Georgescu, AM; Grigorescu, BL, 2015)
" In vivo pharmacokinetic studies in rats by high-performance liquid chromatography confirmed a sustained and sequential release of both the drugs in plasma, indicating prolonged circulation of the nanomedicine and enhanced availability of the drugs when compared to the bare drugs."	1.40	Sequentially releasing dual-drug-loaded PLGA-casein core/shell nanomedicine: design, synthesis, biocompatibility and pharmacokinetics. ( Manzoor, K; Menon, D; Mohan, CC; Narayanan, D; Narayanan, S; Pavithran, M; Viswanath, A, 2014)
"In the conventional treatment of osteomyelitis, the penetration of antibiotics into the infected bone is commonly poor."	1.40	Inflammation-induced drug release by using a pH-responsive gas-generating hollow-microsphere system for the treatment of osteomyelitis. ( Chia, WT; Chung, MF; Hsiao, CW; Hsiao, HC; Liu, HY; Sung, HW; Yang, CM, 2014)
" The aim of this study to assess the bioavailability and safety of SFAs as drug solvents for the topical ocular application of Cyclosporin A (CsA)."	1.40	Semifluorinated alkanes as a liquid drug carrier system for topical ocular drug delivery. ( Dutescu, RM; Merkel, OM; Panfil, C; Schrage, N, 2014)
"In full thickness excisional wounds, the treatment with PLGA-LL37 NP significantly accelerated wound healing compared to PLGA or LL37 administration alone."	1.40	PLGA nanoparticles loaded with host defense peptide LL37 promote wound healing. ( Chereddy, KK; Comune, M; Ferreira, LS; Her, CH; Lam, MC; Lopes, A; Moia, C; Porporato, PE; Préat, V; Sonveaux, P; Steinstraesser, L; Vanacker, J; Vandermeulen, G; Zhu, H, 2014)
" This dosage form permits the prolonged drug release."	1.39	Evaluation of the effects of thalidomide-loaded biodegradable devices in solid Ehrlich tumor. ( Dantas Cassali, G; Ligorio Fialho, S; Maria de Souza, C; Pereira, BG; Silva-Cunha, A, 2013)
"At baseline, COPD patients showed greater muscle oxidative stress and superoxide dismutase activity and circulating inflammatory cytokines than controls."	1.38	Muscle and blood redox status after exercise training in severe COPD patients. ( Barreiro, E; Cascante, M; Falciani, F; Gea, J; Kalko, S; Perez-Olabarría, M; Puig-Vilanova, E; Roca, J; Rodriguez, DA, 2012)
" We conclude that NQC with greater bioavailability offers significantly higher potency in downregulating MMP-9 and NOS-2 as well as oxidative stress in blocking ethanol-induced gastric ulcer."	1.38	The use of nano-quercetin to arrest mitochondrial damage and MMP-9 upregulation during prevention of gastric inflammation induced by ethanol in rat. ( Chakraborty, S; Choudhury, ST; Das, N; Ghosh, S; Stalin, S; Swarnakar, S, 2012)
"Bacterial translocation occurs in ESRD patients and is associated with microinflammation in end stage renal disease."	1.38	Gut bacterial translocation is associated with microinflammation in end-stage renal disease patients. ( Cheng, S; Jiang, H; Ren, Y; Shi, K; Wang, F; Zhang, P, 2012)
"Monofocal acute inflammatory demyelination (MAID), which is observable by CT and MRI as a well-enhanced mass lesion with prominent perifocal edema, is very similar to malignant gliomas radiologically, making differential diagnosis of the two pathologies difficult."	1.37	Metabolic assessment of monofocal acute inflammatory demyelination using MR spectroscopy and (11)C-methionine-, (11)C-choline-, and (18)F-fluorodeoxyglucose-PET. ( Aki, T; Asano, Y; Ito, T; Iwama, T; Miwa, K; Shinoda, J; Takenaka, S; Yokoyama, K, 2011)
"Implant-associated inflammation is a major cause for the reduced performance/lifetime and failure of numerous medical devices."	1.37	Minimally invasive, longitudinal monitoring of biomaterial-associated inflammation by fluorescence imaging. ( García, AJ; Kundu, K; Murthy, N; Selvam, S; Templeman, KL, 2011)
" The results suggest that the chronic intake of caffeine, as well as chronic low-intensity exercise, decreased muscle damage and inflammatory infiltration into skeletal muscle."	1.37	Effects of chronic caffeine intake and low-intensity exercise on skeletal muscle of Wistar rats. ( da Costa Santos, VB; de Paula Ramos, S; Juliani, LC; Nakamura, FY; Polito, MD; Ruiz, RJ; Siqueira, CP; Vettorato, ED, 2011)
"The number of mesh-based therapies of inguinal hernias is increasing compared with the classical suture techniques such as Shouldice and Bassini."	1.36	Influence of a new self-gripping hernia mesh on male fertility in a rat model. ( Hollinsky, C; Joachim, A; Kolbe, T; Rülicke, T; Walter, I, 2010)
"The resuscitation strategy for hemorrhagic shock remains controversial, with the kidney being especially prone to hypoxia."	1.36	Fluid resuscitation does not improve renal oxygenation during hemorrhagic shock in rats. ( Balestra, GM; Ince, C; Legrand, M; Lutter, R; Mik, EG; Payen, D; Pirracchio, R, 2010)
"5-Fluorouracil (5-FU) was used as a model drug, and hydroxyapatite (HA) was incorporated as a release modifier."	1.36	In vitro / in vivo evaluation of NCDS-micro-fabricated biodegradable implant. ( Ahn, SH; Chi, SC; Danh, SD; Park, CW; Park, ES; Park, SH; Rhee, YS, 2010)
"The pathogenic role of disseminated intravascular coagulation (DIC) during septic shock is incompletely understood."	1.36	Relation between coagulation/fibrinolysis and lactate in the course of human septic shock. ( Groeneveld, AB; Hack, CE; Hartemink, KJ, 2010)
"Daily stavudine administration induced mechanical hyperalgesia within three weeks, which was sustained until week six, but the hyperalgesia was not associated with neuronal apoptosis or necrosis, or elevated IL-6 concentrations in the spinal cord."	1.35	Hyperalgesia induced by oral stavudine administration to rats does not depend on spinal neuronal cell death, or on spinal or systemic inflammatory cytokine secretion, or metabolic dysregulation. ( Kamerman, PR; Mitchell, B; Mitchell, D; Veliotes, D; Weber, J, 2009)
"Histoplasmosis is a pulmonary disease characterised by chronic granulomatous and suppurative inflammatory reactions caused by Histoplasma capsulatum."	1.35	Leukotriene B4-loaded microspheres as a new approach to enhance antimicrobial responses in Histoplasma capsulatum-infected mice. ( Faccioli, LH; Nicolete, R; Pereira, PA; Secatto, A; Soares, EG, 2009)
"Alzheimer's disease is characterized by beta-amyloid plaques, tau pathology, cell death of cholinergic neurons, inflammatory processes and cerebrovascular damage."	1.35	[Does acidosis in brain play a role in Alzheimer's disease?]. ( Humpel, C; Pirchl, M, 2009)
"For the glabellar region, severe partly vascular adverse events have been reported after treatment with injectable fillers."	1.35	The spectrum of adverse reactions after treatment with injectable fillers in the glabellar region: results from the Injectable Filler Safety Study. ( Bachmann, F; Erdmann, R; Hartmann, V; Rzany, B; Wiest, L, 2009)
"Inflammation was significantly reduced in the tissue surrounding the dexamethasone microspheres compared to the positive control (empty microspheres) and the number of inflammatory cells was similar to that of normal tissue within one to three days."	1.35	Evaluation of in vivo-in vitro release of dexamethasone from PLGA microspheres. ( Burgess, DJ; Zolnik, BS, 2008)
"To highlight selected adverse effects of continuous renal replacement therapy and to suggest measures for reducing harm."	1.34	Primum non nocere, safety of continuous renal replacement therapy. ( Oudemans-van Straaten, HM, 2007)
"The conditions included seizures, inflammatory changes, and proven metabolic disorders."	1.33	The significance of elevated CSF lactate. ( Chow, SL; Clayton, PT; Cleary, MA; Leonard, JV; Rooney, ZJ, 2005)
"Lactic acid levels were documented at five different time points: 10 min after beginning of cardiopulmonary bypass, 40 min after cardiopulmonary bypass termination, and 30 min, 8h, and 16 h after the surgery."	1.33	IL-10 and TNF-beta gene polymorphisms have no major influence on lactate levels after cardiac surgery. ( Brezina, A; Hubacek, JA; Kellovsky, P; Pirk, J; Poledne, R; Riha, H, 2006)
"Hemorrhagic shock was induced in 48 anesthetized rats by withdrawing 28 mL/kg blood."	1.33	Fluid resuscitation with hemoglobin-vesicle solution does not increase hypoxia or inflammatory responses in moderate hemorrhagic shock. ( Goto, Y; Horinouchi, H; Miyashita, M; Sakai, H; Sakamoto, A; Terajima, K; Tsuchida, E; Tsueshita, T, 2006)
" Their pharmacokinetic and biodistribution profiles were compared in normal rats and rats with carrageenan-induced inflammation after intravenous application of about 5 mg/kg of each copolymer."	1.32	Pharmacokinetics and distribution of 125I-PLA-b-PEO block copolymers in rats. ( Laznicek, M; Machova, L; Novakova, K; Rypacek, F, 2003)
"The treatment of hemorrhagic shock (HeS) with large volumes of fluid does not ensure an adequate peripheral perfusion or prevent inflammatory activation despite hemodynamic recovery."	1.32	Hypertonic saline improves tissue oxygenation and reduces systemic and pulmonary inflammatory response caused by hemorrhagic shock. ( Birolini, D; da Costa Ferreira Novo, F; Fontes, B; Gurfinkel, V; Poggetti, RS, 2003)
"However, meningitis-induced CSF leukocytosis at 4 h and increased CSF lactate and tumor necrosis factor alpha levels were not significantly attenuated."	1.31	7-Nitroindazole, but not aminoguanidine, attenuates the acute inflammatory responses and brain injury during the early phase of Escherichia coli meningitis in the newborn piglet. ( Chang, YS; Lee, M; Park, WS, 2001)
" Two different in vivo studies were performed, the first to find the dosage level of dexamethasone that effectively would suppress the acute inflammatory reaction and the second to show how effective the dexamethasone delivered by PLGA microspheres was in suppressing chronic inflammatory response to an implant."	1.31	In vivo evaluation of a dexamethasone/PLGA microsphere system designed to suppress the inflammatory tissue response to implantable medical devices. ( Burgess, DJ; Hickey, T; Kreutzer, D; Moussy, F, 2002)
"During a healing period of 6 weeks, gingival recession resulting in device exposure occurred at 3 test and 10 control sites."	1.29	The influence of the design of two different bioresorbable barriers on the results of guided tissue regeneration therapy. An intra-individual comparative study in the monkey. ( Gottlow, J; Laurell, L; Lundgren, D; Mathisen, T; Nyman, S; Rask, M; Rylander, H, 1995)
"Inflammation was induced by the placement of a catheter in the carotid artery."	1.29	Potentiation of decreased pyruvate dehydrogenase activity by inflammatory stimuli in sepsis. ( Martin, LF; Vary, TC, 1993)

Research

Studies (371)

Authors

Clinical Trials (15)

Trial Overview

Trial Outcomes

Elasticity

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (0.27)	18.7374
1990's	19 (5.12)	18.2507
2000's	78 (21.02)	29.6817
2010's	191 (51.48)	24.3611
2020's	82 (22.10)	2.80

Authors	Studies
Luo, Y	1
Li, L	2
Chen, X	2
Gou, H	1
Yan, K	1
Xu, Y	5
Popov, IV	1
Mazanko, MS	1
Kulaeva, ED	1
Golovin, SN	1
Malinovkin, AV	1
Aleshukina, IS	1
Aleshukina, AV	1
Prazdnova, EV	1
Tverdokhlebova, TI	1
Chikindas, ML	1
Ermakov, AM	1
Roy, S	1
Kumaravel, S	1
Banerjee, P	1
White, TK	1
O'Brien, A	1
Seelig, C	1
Chauhan, R	1
Ekser, B	1
Bayless, KJ	1
Alpini, G	1
Glaser, SS	1
Chakraborty, S	2
Lindholm, E	1
Bergmann, GB	1
Haugaa, H	1
Labori, KJ	1
Yaqub, S	1
Bjørnbeth, BA	1
Line, PD	1
Grindheim, G	1
Kjøsen, G	1
Pischke, SE	1
Tønnessen, TI	1
Lin, Y	2
Bai, M	1
Wang, S	2
Chen, L	1
Li, Z	2
Li, C	3
Cao, P	1
Chen, Y	2
Manosalva, C	1
Quiroga, J	1
Hidalgo, AI	1
Alarcón, P	1
Anseoleaga, N	1
Hidalgo, MA	1
Burgos, RA	1
Cai, H	1
Wang, X	3
Zhang, Z	6
Chen, J	5
Wang, F	6
Wang, L	3
Liu, J	2
Yi, O	1
Hu, M	1
Hu, S	1
Su, Z	1
Liao, J	1
Liu, B	3
Liu, L	4
Cai, X	1
Kolpen, M	2
Dalby Sørensen, C	1
Faurholt-Jepsen, D	2
Hertz, FB	1
Jensen, PØ	2
Bestle, MH	1
Wang, Y	10
Li, J	8
Wang, MY	1
Pan, ZY	1
Li, ZQ	1
Wang, ZF	1
Agrawal, S	1
Monteiro, C	1
Baca, CF	1
Mohammadi, R	1
Subramanian, V	1
de Melo Bento, CA	1
Agrawal, A	1
Nielsen, BU	1
Pressler, T	1
Mathiesen, IHM	1
Lähteenmäki, EI	1
Koski, M	1
Koskela, I	1
Lehtonen, E	1
Kankaanpää, A	1
Kainulainen, H	1
Walker, S	1
Lehti, M	1
Zhu, L	1
Hu, W	1
Dai, J	1
Ren, P	1
Shao, X	1
Xiong, B	1
Zhang, T	2
Ji, Z	2
Certo, M	3
Llibre, A	1
Lee, W	1
Mauro, C	6
Li, X	5
Yang, Y	2
Zhang, B	1
Lin, X	1
Fu, X	1
An, Y	1
Zou, Y	1
Wang, JX	1
Wang, Z	4
Yu, T	1
Feng, T	2
Zhao, X	3
Gu, P	1
Yang, W	1
Wang, C	1
Guo, Q	2
Long, Q	1
Liu, Q	1
Cheng, Y	1
Cheung, CKY	1
Wu, D	3
Kong, X	1
Ye, D	1
Hua, S	1
Loomes, K	1
Xu, A	1
Hui, X	1
Sun, Y	1
Qiu, C	1
Du, N	1
Lin, H	2
Zhang, A	1
Cao, C	1
Hu, X	2
Zhang, J	3
Pan, X	1
Zhu, Y	3
Qian, F	2
Zhao, D	1
Liu, M	2
Huang, Y	2
Yan, Y	1
Yang, Q	1
Zhang, H	2
Hettinga, K	1
Li, H	4
Chen, W	2
Zhou, HC	2
Yu, WW	2
Yan, XY	1
Liang, XQ	2
Ma, XF	1
Long, JP	2
Du, XY	2
Mao, HY	1
Liu, HB	2
Bhatia, R	3
Singh, S	3
Maurya, R	3
Bhadada, SK	3
Bishnoi, M	3
Chopra, K	3
Joshi, SR	3
Kondepudi, KK	3
Taylor, SJ	3
Winter, MG	3
Gillis, CC	3
Silva, LAD	3
Dobbins, AL	3
Muramatsu, MK	3
Jimenez, AG	3
Chanin, RB	3
Spiga, L	3
Llano, EM	3
Rojas, VK	3
Kim, J	3
Santos, RL	3
Zhu, W	3
Winter, SE	3
Wu, Y	4
Ma, W	2
Liu, W	4
Zhang, S	5
Xu, J	2
Ji, T	1
Li, G	1
Zheng, Y	1
Li, M	1
Ma, J	1
Li, Y	3
Chi, G	1
Yu, W	1
Fang, Y	2
Zhou, H	2
Liang, Y	3
Huang, C	2
Liu, H	3
Zhao, G	1
Schilperoort, M	1
Ngai, D	1
Katerelos, M	1
Power, DA	1
Tabas, I	1
Shin, MJ	1
Lee, CS	1
Kim, SH	1
Shi, W	1
Fuad, ARM	1
Huang, J	1
Du, R	1
Wang, G	2
Yin, T	1
Zhang, D	5
Tu, H	1
Alimi, OA	1
Kong, Y	1
Satyanarayana, R	1
Kuss, M	1
Duan, B	1
Hong, H	1
Su, J	1
Zhang, Y	3
Xu, G	1
Bao, G	1
Cui, Z	2
Wu, S	1
Cui, W	2
Zhou, Q	1
Li, P	1
Gu, Q	1
Pucino, V	5
Nefla, M	1
Gauthier, V	1
Alsaleh, G	1
Clayton, SA	1
Marshall, J	1
Filer, A	1
Clark, AR	1
Raza, K	1
Buckley, CD	1
Altaie, AM	1
Mohammad, MG	1
Madkour, MI	1
AlSaegh, MA	1
Jayakumar, MN	1
K G, AR	1
Samsudin, AR	1
Halwani, R	1
Hamoudi, RA	1
Soliman, SSM	1
Sharma, S	1
Gowda, P	1
Lathoria, K	1
Mitra, MK	1
Sen, E	1
Zhao, H	1
Wen, Z	1
Xiong, S	1
Feldo, M	1
Wójciak, M	1
Dresler, S	1
Sowa, P	1
Płachno, BJ	1
Samborski, D	1
Sowa, I	1
Jiang, R	1
Luo, S	1
Zhang, M	3
Wang, W	2
Zhuo, S	1
Qiu, Q	1
Yuan, Y	1
Jiang, X	3
Sanches, E	1
van de Looij, Y	1
Ho, D	1
Modernell, L	1
da Silva, A	1
Sizonenko, S	1
Roy, RM	1
Allawzi, A	1
Burns, N	1
Sul, C	1
Rubio, V	1
Graham, J	1
Stenmark, K	1
Nozik, ES	1
Tuder, RM	1
Vohwinkel, CU	1
Yamabhai, M	1
Khamphio, M	1
Min, TT	1
Soem, CN	1
Cuong, NC	1
Aprilia, WR	1
Luesukprasert, K	1
Teeranitayatarn, K	1
Maneedaeng, A	1
Tuveng, TR	1
Lorentzen, SB	1
Antonsen, S	1
Jitprasertwong, P	1
Eijsink, VGH	1
Hoffman, WH	1
Ishikawa, T	1
Blum, J	1
Tani, N	1
Ikeda, T	1
Artlett, CM	1
Mariani, CL	1
Nye, CJ	1
Tokarz, DA	1
Green, L	1
Lau, J	1
Zidan, N	1
Early, PJ	1
Guevar, J	1
Muñana, KR	1
Olby, NJ	1
Miles, S	1
Clarke, J	1
Murray, PJ	1
Ivashkiv, LB	1
Marone, G	1
de Paulis, A	1
Chen, SM	1
Lin, CE	1
Chen, HH	1
Cheng, YF	1
Cheng, HW	1
Imai, K	1
Delgado-Diaz, DJ	1
Tyssen, D	2
Hayward, JA	1
Gugasyan, R	2
Hearps, AC	2
Tachedjian, G	2
Liu, P	1
Deng, X	1
Peng, Y	1
Zhou, F	1
Zuo, Z	2
Ding, Y	1
Fan, B	1
Mao, Z	1
Wu, J	2
Ohashi, T	1
Terasawa, K	1
Aoki, M	1
Akazawa, T	1
Shibata, H	1
Kuze, B	1
Asano, T	2
Kato, H	1
Miyazaki, T	1
Matsuo, M	1
Inoue, N	1
Ito, Y	1
Zasłona, Z	1
O'Neill, LAJ	1
Feidantsis, K	1
Georgoulis, I	1
Zachariou, A	1
Campaz, B	1
Christoforou, M	1
Pörtner, HO	1
Michaelidis, B	1
Hu, J	1
Cai, M	1
Liu, Y	6
Xue, X	1
Ji, R	1
Bian, X	1
Lou, S	1
Neveu, MA	1
Beziere, N	1
Daniels, R	1
Bouzin, C	1
Comment, A	1
Schwenck, J	1
Fuchs, K	1
Kneilling, M	1
Pichler, BJ	1
Schmid, AM	1
Liu, S	1
Zhou, D	1
Yang, H	1
Zhang, K	1
Liao, S	1
Tang, S	1
Tan, B	1
Qi, M	1
Zha, A	1
Yin, Y	1
Sun, P	1
Tang, Y	1
Bozdemir-Ozel, C	1
Arikan, H	1
Calik-Kutukcu, E	1
Karadüz, BN	1
Inal-Ince, D	1
Kabakci, G	1
Sumer, E	1
Dagdelen, S	1
He, LX	1
Abdolmaleky, HM	1
Yin, S	1
Zhou, JR	1
Bian, Q	1
Huang, Q	1
Gao, J	2
Ramot, Y	1
Harnof, S	1
Klein, I	1
Amouyal, N	1
Steiner, M	1
Manassa, NN	1
Bahar, A	1
Rousselle, S	1
Nyska, A	1
Salgado, C	1
Guénée, L	1
Černý, R	1
Allémann, E	1
Jordan, O	1
Tsai, CH	1
Ho, PC	1
Kozioł, K	1
Zebrowski, J	1
Betlej, G	1
Bator, E	1
Czarny, W	1
Bajorek, W	1
Czarnota, B	1
Czaja, R	1
Król, P	1
Kwiatkowska, A	1
Wang, J	4
Meng, W	1
Huang, S	1
Wu, Z	1
Pang, J	1
Han, D	1
Yang, K	1
Fan, M	1
Tu, F	1
Ha, T	1
Williams, DL	1
Bakalov, V	1
Reyes-Uribe, L	1
Deshpande, R	1
Maloy, AL	1
Shapiro, SD	1
Angus, DC	1
Chang, CH	1
Le Moyec, L	1
Wendell, SG	1
Kaynar, AM	1
Suleiman, JB	1
Nna, VU	1
Zakaria, Z	1
Othman, ZA	1
Eleazu, CO	1
Abu Bakar, AB	1
Ahmad, A	1
Usman, UZ	1
Abdul Rahman, WFW	1
Mohamed, M	1
Bhusal, A	1
Rahman, MH	1
Lee, WH	1
Lee, IK	2
Suk, K	2
Pla, R	1
Pujos-Guillot, E	1
Durand, S	1
Brandolini-Bunlon, M	1
Centeno, D	1
Pyne, DB	1
Toussaint, JF	1
Hellard, P	1
Ding, H	1
Wang, JJ	2
Zhang, XY	1
Yin, L	1
Tuniyazi, M	1
He, J	1
Guo, J	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Early Detection of Anastomotic Leakage by Microdialysis Catheters: An Observational Study on Pancreaticoduodenectomy[NCT03627559]		35 participants (Actual)	Observational	2013-10-01	Completed
The Early Predictive Roles of NLR and NE% in In-hospital Mortality of Septic Patients: a Single-center 13-year Retrospective Study[NCT05636202]		606 participants (Actual)	Observational	2022-12-01	Completed
Effect of Probiotics on Modulating the Bacterial Translocation and Improving Micro-inflammation in Hemodialysis Patients[NCT02929225]	Early Phase 1	50 participants (Actual)	Interventional	2016-12-31	Completed
Digoxin In Treatment of Alcohol Associated Hepatitis (DIGIT-AlcHep)[NCT05014087]	Phase 2	60 participants (Anticipated)	Interventional	2021-10-08	Recruiting
Anhydrous Enol-Oxaloacetate (AEO) on Improving Fatigue in Post-COVID-19 Survivors[NCT04592354]		40 participants (Anticipated)	Interventional	2020-10-15	Recruiting
Oxaloacetate Supplementation for Emotional PMS; Measuring Improvements in Depression, Anxiety, Perceived Stress, and Aggression[NCT03509714]		48 participants (Actual)	Interventional	2016-10-17	Completed
A Randomized Double Blind Placebo Controlled Trial to Determine the Effects of Oxaloacetate on Improving Fatigue in ME/CFS[NCT05273372]		80 participants (Anticipated)	Interventional	2022-03-15	Enrolling by invitation
Hydrogen-Rich Celsior Solution Improve the Quality of Aging DBD Grafts in Liver/Kidney Transplantation: Prospective, Randomized Clinical Trial[NCT02613195]	Phase 3	20 participants (Anticipated)	Interventional	2016-01-31	Not yet recruiting
Phase I/II Comparative Study of a Single Intraoperative Sub-Tenon's Capsule Injection of Triamcinolone and Ciprofloxacin in a Controlled-Release System Versus 1% Prednisolone and 0.3% Ciprofloxacin Eyedrops for Cataract Surgery[NCT00431028]	Phase 1/Phase 2	140 participants (Actual)	Interventional	2005-09-30	Terminated (stopped due to Terminated)
Split-face Study of Changing in Skin Physiology and Clinical Appearance After Microdroplet Placement of Stabilized Hyaluronic Acid in Aging Faces[NCT02312154]	Phase 4	25 participants (Actual)	Interventional	2014-04-30	Completed
Vitamins C and E Combined With Cryotherapy on the Pain, Oxidative Stress and Inflammatory Response After Resistance Exercise Session in Untrained Volunteers[NCT02902315]		26 participants (Actual)	Interventional	2017-01-04	Completed
Removal of Cytokines in Patients Undergoing Cardiac Surgery With CPB (The REMOTE Study)[NCT03104179]		80 participants (Anticipated)	Interventional	2017-05-31	Not yet recruiting
Does Modified Ultrafiltration Improves Inflammatory Response and Cardiopulmonary Function After CABG Procedures?[NCT01140113]		60 participants (Actual)	Interventional	2007-07-31	Completed
Evaluation of Corticosteroid Therapy in Childhood Severe Sepsis (Steroids in Paediatric Sepsis, StePS) - a Randomised Pilot Study[NCT00732277]	Phase 2	21 participants (Actual)	Interventional	2008-04-30	Completed
Conservative vs Conventional Oxygen Administration in Critically Ill Patients: Effects on ICU Mortality. A Multicentre Randomized Open Label Clinical Trial[NCT04198077]	Phase 4	1,000 participants (Anticipated)	Interventional	2019-12-04	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

"We measured a elasticity by a reviscometer device (Courage & Khazaka, Cologne, Germany).~The range of elasticity was 0 (most elastic possible as) ~400 AU(Arbitrary Unit) (inelastic as possible)" (NCT02312154)
Timeframe: 12 weeks

Erythema Index

Intervention	AU (arbitrary unit) (Mean)
Treated Side (Restylane Vital)	242.33
Untreated Side	271.15

"We measured an erythema index by a mexameter device (Courage & Khazaka, Cologne, Germany).~The range of erythema index is 0~999 AU(Arbitrary Unit). The range of erythema index was 0 (as non-erythematous as possible) ~999 AU (most erythematous possible)" (NCT02312154)
Timeframe: 12 weeks

Global Aesthetic Improvement Scale (Investigator)

Intervention	AU (arbitrary unit) (Mean)
Treated Side (Restylane Vital)	253.66
Untreated Side	243.53

The therapeutic outcome was assessed by investigator using the Global Aesthetic Improvement Scale (GAIS), which rates outcome on the following 5-point scale: 3, very much improved; 2, much improved; 1, improved; 0, no change; and -1, worse. (NCT02312154)
Timeframe: 12 weeks

Global Aesthetic Improvement Scale (Subject)

Intervention	scores on a scale (Mean)
Treated Side (Restylane Vital)	1.38
Untreated Side	0

The therapeutic outcome was assessed by patient self-assessment using the Global Aesthetic Improvement Scale (GAIS), which rates outcome on the following 5-point scale: 3, very much improved; 2, much improved; 1, improved; 0, no change; and -1, worse (NCT02312154)
Timeframe: 12 weeks

Hydration Level

Intervention	scores on a scale (Mean)
Treated Side (Restylane Vital)	1.33
Untreated Side	0

"We measured a hydration level by a corneometer device (Courage & Khazaka, Cologne, Germany).~The range of hydration level was 0 (as dry as possible) ~120 AU (Arbitrary Unit)(most moist possible)" (NCT02312154)
Timeframe: 12 weeks

Melanin Index

Intervention	AU (arbitrary unit) (Mean)
Treated Side (Restylane Vital)	53.19
Untreated Side	46.75

"We measured a melanin index by a mexameter device (Courage & Khazaka, Cologne, Germany).~The range of melanin index was 0 (as bright as possible) ~999 AU (Arbitrary Unit) (most dark possible)." (NCT02312154)
Timeframe: 12 weeks

Article	Year
Effects of lactate in immunosuppression and inflammation: Progress and prospects. International reviews of immunology, 2022, Volume: 41, Issue:1 Topics: Humans; Immunosuppression Therapy; Inflammation; Lactic Acid; Neoplasms; Receptors, G-Protein-Couple	2022
Role of Lactate in Inflammatory Processes: Friend or Foe. Frontiers in immunology, 2021, Volume: 12 Topics: Animals; Biological Transport; Biomarkers; Cytokines; Disease Susceptibility; Energy Metabolism; Hum	2021
Lactate metabolism in rheumatoid arthritis: Pathogenic mechanisms and therapeutic intervention with natural compounds. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2022, Volume: 100 Topics: Arthritis, Rheumatoid; Fibroblasts; Humans; Inflammation; Lactic Acid; Synovial Membrane	2022
Understanding lactate sensing and signalling. Trends in endocrinology and metabolism: TEM, 2022, Volume: 33, Issue:10 Topics: Humans; Inflammation; Lactic Acid; Neoplasms; Signal Transduction	2022
Lactate metabolism in human health and disease. Signal transduction and targeted therapy, 2022, 09-01, Volume: 7, Issue:1 Topics: Glycolysis; Homeostasis; Humans; Inflammation; Lactic Acid; Neoplasms	2022
Lactate: a pearl dropped in the ocean-an overlooked signal molecule in physiology and pathology. Cell biology international, 2023, Volume: 47, Issue:2 Topics: Glycolysis; Humans; Inflammation; Lactic Acid; Oceans and Seas	2023
Lactate: a pearl dropped in the ocean-an overlooked signal molecule in physiology and pathology. Cell biology international, 2023, Volume: 47, Issue:2 Topics: Glycolysis; Humans; Inflammation; Lactic Acid; Oceans and Seas	2023
Lactate: a pearl dropped in the ocean-an overlooked signal molecule in physiology and pathology. Cell biology international, 2023, Volume: 47, Issue:2 Topics: Glycolysis; Humans; Inflammation; Lactic Acid; Oceans and Seas	2023
Lactate: a pearl dropped in the ocean-an overlooked signal molecule in physiology and pathology. Cell biology international, 2023, Volume: 47, Issue:2 Topics: Glycolysis; Humans; Inflammation; Lactic Acid; Oceans and Seas	2023
On macrophage diversity and inflammatory metabolic timers. Nature reviews. Immunology, 2020, Volume: 20, Issue:2 Topics: Animals; Gene Expression; Gene Expression Profiling; Humans; Inflammation; Lactic Acid; Lung Neoplas	2020
Lactate: Fueling the fire starter. Wiley interdisciplinary reviews. Systems biology and medicine, 2020, Volume: 12, Issue:3 Topics: Glucose; Humans; Inflammation; Lactic Acid; Monocarboxylic Acid Transporters; Neoplasms; Signal Tran	2020
Cytokine-like Roles for Metabolites in Immunity. Molecular cell, 2020, 06-04, Volume: 78, Issue:5 Topics: Animals; Carboxylic Acids; Citric Acid Cycle; Cytokines; Energy Metabolism; Humans; Immunity; Inflam	2020
The roles of GRP81 as a metabolic sensor and inflammatory mediator. Journal of cellular physiology, 2020, Volume: 235, Issue:12 Topics: Adipocytes; Adipose Tissue; Animals; Humans; Inflammation; Inflammation Mediators; Lactic Acid; Sign	2020
Lactate modulation of immune responses in inflammatory versus tumour microenvironments. Nature reviews. Immunology, 2021, Volume: 21, Issue:3 Topics: Biological Availability; Carrier Proteins; Humans; Inflammation; L-Lactate Dehydrogenase; Lactic Aci	2021
COVID-19 and diabetes: the contributions of hyperglycemia. Journal of molecular cell biology, 2020, 09-07, Volume: 12, Issue:12 Topics: Angiotensin-Converting Enzyme 2; Blood Glucose; COVID-19; Cytokine Release Syndrome; Diabetes Compli	2020
The potential use of lactate blockers for the prevention of COVID-19 worst outcome, insights from exercise immunology. Medical hypotheses, 2021, Volume: 148 Topics: Anaerobiosis; COVID-19; COVID-19 Drug Treatment; Exercise; Humans; Inflammation; Interleukin-6; Lact	2021
Taurine in sports and exercise. Journal of the International Society of Sports Nutrition, 2021, May-26, Volume: 18, Issue:1 Topics: Athletic Performance; Blood Glucose; Body Temperature Regulation; Calcium; Dietary Supplements; Ener	2021
Lactic acid in macrophage polarization: The significant role in inflammation and cancer. International reviews of immunology, 2022, Volume: 41, Issue:1 Topics: Humans; Inflammation; Lactic Acid; Macrophage Activation; Macrophages; Neoplasms; Signal Transductio	2022
The Metabolic Microenvironment Steers Bone Tissue Regeneration. Trends in endocrinology and metabolism: TEM, 2018, Volume: 29, Issue:2 Topics: Animals; Bone Regeneration; Fractures, Bone; Humans; Inflammation; Lactic Acid; Mesenchymal Stem Cel	2018
Lactate transporters as therapeutic targets in cancer and inflammatory diseases. Expert opinion on therapeutic targets, 2018, Volume: 22, Issue:9 Topics: Animals; Biological Transport; Cell Membrane; Drug Design; Humans; Inflammation; Lactic Acid; Molecu	2018
Exosomes in Inflammation and Inflammatory Disease. Proteomics, 2019, Volume: 19, Issue:8 Topics: Amino Acids; Animals; Cell Proliferation; Exosomes; Fibroblasts; Glycogen; Humans; Inflammation; Lac	2019
Delayed onset muscle soreness: is massage effective? Journal of bodywork and movement therapies, 2013, Volume: 17, Issue:4 Topics: Creatine Kinase; Humans; Inflammation; Lactic Acid; Massage; Muscle, Skeletal; Myalgia; Sports Medic	2013
Biomaterial scaffolds used for the regeneration of spinal cord injury (SCI). Histology and histopathology, 2014, Volume: 29, Issue:11 Topics: Alginates; Animals; Apoptosis; Axons; Biocompatible Materials; Chitosan; Collagen; Disease Models, A	2014
Postinflammatory hyperpigmentation in patients with skin of color. Cutis, 2016, Volume: 97, Issue:1 Topics: Chemexfoliation; Dermatitis; Dermatologic Agents; Dicarboxylic Acids; Drug Combinations; Ethanol; Gl	2016
Lactate at the crossroads of metabolism, inflammation, and autoimmunity. European journal of immunology, 2017, Volume: 47, Issue:1 Topics: Animals; Arthritis, Rheumatoid; Autoimmune Diseases; Autoimmunity; Energy Metabolism; Humans; Immune	2017
Bio-ecological control of chronic liver disease and encephalopathy. Metabolic brain disease, 2009, Volume: 24, Issue:1 Topics: Dietary Proteins; Feeding Behavior; Food, Formulated; Hepatic Encephalopathy; Humans; Inflammation;	2009
PLGA-based nanoparticles: an overview of biomedical applications. Journal of controlled release : official journal of the Controlled Release Society, 2012, Jul-20, Volume: 161, Issue:2 Topics: Animals; Bacterial Infections; Brain Diseases; Cardiovascular Diseases; Drug Delivery Systems; Human	2012
Metabolomics--a novel window into inflammatory disease. Swiss medical weekly, 2013, Volume: 143 Topics: Animals; Biomarkers; Energy Metabolism; Humans; Hypoxia; Inflammation; Lactic Acid; Metabolomics; Me	2013
Patterns of oxygen transport in trauma and their relationship to outcome. The American journal of emergency medicine, 1994, Volume: 12, Issue:1 Topics: Humans; Inflammation; Lactates; Lactic Acid; Oxygen; Prognosis; Shock; Wounds and Injuries	1994
Biocompatibility of new peritoneal dialysis solutions: what can we hope to achieve? Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis, 2000, Volume: 20 Suppl 5 Topics: Amino Acids; Arteriosclerosis; Bicarbonates; Dialysis Solutions; Glucans; Glucose; Humans; Icodextri	2000
Inflammation, glycolytic metabolism, and glycosaminoglycans. Experimental pathology, 1986, Volume: 30, Issue:1 Topics: Aerobiosis; Animals; Cell Division; Cells, Cultured; Glycolysis; Glycosaminoglycans; Hypoxia; Inflam	1986

Article	Year
Cytochrome c in patients undergoing coronary artery bypass grafting: A post hoc analysis of a randomized trial. Journal of critical care, 2017, Volume: 42 Topics: Aged; Biomarkers; Cardiopulmonary Bypass; Coronary Artery Bypass; Cytochromes c; Double-Blind Method	2017
Single-arm study for the characterization of human tissue response to injectable poly-L-lactic acid. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2013, Volume: 39, Issue:6 Topics: Adult; Female; Fibrillar Collagens; Humans; Inflammation; Injections, Intradermal; Lactic Acid; Male	2013
Effect of repeat-sprint training in hypoxia on post-exercise interleukin-6 and F2-isoprostanes. European journal of sport science, 2016, Volume: 16, Issue:8 Topics: Adult; Altitude; F2-Isoprostanes; Heart Rate; Humans; Hypoxia; Inflammation; Interleukin-6; Lactic A	2016
The inflammatory response to colloids and crystalloids used for pump priming during cardiopulmonary bypass. Acta anaesthesiologica Scandinavica, 2008, Volume: 52, Issue:9 Topics: Aged; C-Reactive Protein; Cardiopulmonary Bypass; Cardiovascular Diseases; Colloids; Complement C4;	2008
A single intraoperative sub-tenon's capsule injection of triamcinolone and ciprofloxacin in a controlled-release system for cataract surgery. Investigative ophthalmology & visual science, 2009, Volume: 50, Issue:7 Topics: Aged; Anterior Chamber; Anti-Infective Agents; Anti-Inflammatory Agents; Ciprofloxacin; Connective T	2009
Cycling performance following adaptation to two protocols of acutely intermittent hypoxia. International journal of sports physiology and performance, 2009, Volume: 4, Issue:1 Topics: Adaptation, Physiological; Adult; Bicycling; Confidence Intervals; Exercise Test; Heart Rate; Humans	2009
Intensive versus conventional insulinotherapy after elective and on-pump myocardial revascularization: a prospective and randomized study. La Clinica terapeutica, 2010, Volume: 161, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Elective Surgical Procedures; Hemodynamics; Humans; Hypoglycemic Age	2010
Effects of oral supplementation with plant superoxide dismutase extract on selected redox parameters and an inflammatory marker in a 2,000-m rowing-ergometer test. International journal of sport nutrition and exercise metabolism, 2011, Volume: 21, Issue:2 Topics: Administration, Oral; Antioxidants; Biomarkers; C-Reactive Protein; Creatine Kinase; Exercise; Gluta	2011
Menhaden oil administration to dogs treated with radiation for nasal tumors demonstrates lower levels of tissue eicosanoids. Nutrition research (New York, N.Y.), 2011, Volume: 31, Issue:12 Topics: Animals; Carcinoma; Dietary Fats; Dogs; Double-Blind Method; Eicosanoids; Energy Metabolism; Fish Oi	2011
Leukocyte filtration of blood cardioplegia attenuates myocardial damage and inflammation. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2013, Volume: 43, Issue:1 Topics: Aged; Analysis of Variance; Aortic Valve; Aortic Valve Stenosis; Cytokines; Female; Heart Arrest, In	2013
Use of modified ultrafiltration in adults undergoing coronary artery bypass grafting is associated with inflammatory modulation and less postoperative blood loss: a randomized and controlled study. The Journal of thoracic and cardiovascular surgery, 2012, Volume: 144, Issue:3 Topics: Analysis of Variance; Biomarkers; Brazil; Cardiopulmonary Bypass; Chest Tubes; Coronary Artery Bypas	2012
Effect of supplemental oxygen on post-exercise inflammatory response and oxidative stress. European journal of applied physiology, 2013, Volume: 113, Issue:4 Topics: Administration, Inhalation; Analysis of Variance; Biomarkers; Exercise Test; Heart Rate; Humans; Hyp	2013
Release of algesic substances in human experimental muscle pain. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2002, Volume: 51, Issue:8 Topics: Adult; Arm; Dinoprostone; Exercise; Female; Glutamic Acid; Humans; Hypertonic Solutions; Inflammatio	2002
Modulation of the inflammatory response to cardiopulmonary bypass by dopexamine and epidural anesthesia. Acta anaesthesiologica Scandinavica, 2002, Volume: 46, Issue:10 Topics: Aged; Anesthesia, Epidural; Anti-Inflammatory Agents; C-Reactive Protein; Calcitonin; Calcitonin Gen	2002
Fixation of osteochondritis dissecans lesions using poly(l-lactic acid)/ poly(glycolic acid) copolymer bioabsorbable screws. The American journal of sports medicine, 2005, Volume: 33, Issue:1 Topics: Absorption; Adolescent; Adult; Biocompatible Materials; Biomechanical Phenomena; Bone Screws; Female	2005
Spinal anesthesia with an indwelling catheter reduces the stress response in pediatric open heart surgery. Anesthesiology, 2005, Volume: 103, Issue:6 Topics: Anesthesia, General; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthesia, Spinal; Biomarkers	2005
Pre-treatment with hyperoxia before coronary artery bypass grafting - effects on myocardial injury and inflammatory response. Acta anaesthesiologica Scandinavica, 2007, Volume: 51, Issue:10 Topics: Coronary Artery Bypass; Creatine Kinase; Female; Hemodynamics; Humans; Hyperoxia; Inflammation; Inte	2007

lactic acid and Innate Inflammatory Response