lactic acid and Injuries studies

Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.

Injuries: Used with anatomic headings, animals, and sports for wounds and injuries. Excludes cell damage, for which pathology is used.

Research Excerpts

Excerpt	Relevance	Reference
" Our purposes were to study the efficacy of tranexamic acid (TXA) and prothrombin complex concentrate (PCC) on a traumatic coagulopathy with a severe native metabolic acidosis and compare the efficacy of PCC versus fresh frozen plasma (FFP) to reverse a dilutional coagulopathy."	7.79	The effects of tranexamic acid and prothrombin complex concentrate on the coagulopathy of trauma: an in vitro analysis of the impact of severe acidosis. ( Eckert, M; Izenberg, S; Martin, MJ; McVay, D; Nelson, D; Porta, CR; Salgar, S, 2013)
"Diaspirin cross-linked hemoglobin (DCLHb) has demonstrated a pressor effect that could adversely affect traumatic hemorrhagic shock patients through diminished perfusion to vital organs, causing base deficit (BD) and lactate abnormalities."	7.76	Diaspirin cross-linked hemoglobin infusion did not influence base deficit and lactic acid levels in two clinical trials of traumatic hemorrhagic shock patient resuscitation. ( Gao, W; Koenigsberg, MD; Philbin, NB; Sloan, EP, 2010)
"This study has been performed to characterize the relationship between changes in plasma taurine (TAU) and hemodynamic patterns in sepsis."	7.70	Taurine and pulmonary hemodynamics in sepsis. ( Boldrini, G; Castagneto, M; Chiarla, C; Giovannini, I; Siegel, JH, 2000)
" This review discusses 3 issues that concern homeostasis in the acute care of trauma patients directly related to the stress response: hyperglycemia, lactic acidosis, and hypothermia."	4.89	Trauma and aggressive homeostasis management. ( Baranov, D; Neligan, PJ, 2013)
"Three important issues concerning homeostasis in the acute care of trauma patients that are related directly to the stress response are hyperglycemia, lactic acidosis, and hypothermia."	4.84	Trauma and aggressive homeostasis management. ( Baranov, D; Neligan, P, 2007)
" Sustained lactic acidosis, or changes in lactate in response to inotropic support, are useful predictors of mortality in severe sepsis and trauma, and superior to hemodynamic markers such as DO2 and VO2."	4.80	Lactate in sepsis and trauma--hindrance or help? ( Sladen, RN, 1999)
" Our purposes were to study the efficacy of tranexamic acid (TXA) and prothrombin complex concentrate (PCC) on a traumatic coagulopathy with a severe native metabolic acidosis and compare the efficacy of PCC versus fresh frozen plasma (FFP) to reverse a dilutional coagulopathy."	3.79	The effects of tranexamic acid and prothrombin complex concentrate on the coagulopathy of trauma: an in vitro analysis of the impact of severe acidosis. ( Eckert, M; Izenberg, S; Martin, MJ; McVay, D; Nelson, D; Porta, CR; Salgar, S, 2013)
"Diaspirin cross-linked hemoglobin (DCLHb) has demonstrated a pressor effect that could adversely affect traumatic hemorrhagic shock patients through diminished perfusion to vital organs, causing base deficit (BD) and lactate abnormalities."	3.76	Diaspirin cross-linked hemoglobin infusion did not influence base deficit and lactic acid levels in two clinical trials of traumatic hemorrhagic shock patient resuscitation. ( Gao, W; Koenigsberg, MD; Philbin, NB; Sloan, EP, 2010)
" Forty-two percent of nonsurvivors had normal lactate levels, whereas 33% of survivors had lactic acidosis."	3.74	Comparison of acid-base models for prediction of hospital mortality after trauma. ( Kaplan, LJ; Kellum, JA, 2008)
"This study has been performed to characterize the relationship between changes in plasma taurine (TAU) and hemodynamic patterns in sepsis."	3.70	Taurine and pulmonary hemodynamics in sepsis. ( Boldrini, G; Castagneto, M; Chiarla, C; Giovannini, I; Siegel, JH, 2000)
"A prehospital trauma triage algorithm must reliably identify a patient bleeding or suffering from significant brain injuries."	3.01	The potential of point-of-care diagnostics to optimise prehospital trauma triage: a systematic review of literature. ( Ahnert, T; Bieler, D; Imach, S; Neubert, A; Stojek, L, 2023)
"Prehospital plasma transfusion in trauma reduces mortality."	3.01	Lactate as a mediator of prehospital plasma mortality reduction in hemorrhagic shock. ( Brown, JB; Canton, SP; Claridge, JA; Daley, BJ; Guyette, FX; Harbrecht, BG; Lutfi, W; Miller, RS; Phelan, HA; Sperry, JL, 2021)
"Among 111 non-massively bleeding trauma patients, 40 presented no indication for transfusion."	2.87	Blood Transfusion Indicators Following Trauma in the Non-Massively Bleeding Patient. ( Fontaine, MJ; Hu, PF; Kozar, RA; Li, HC; Mackenzie, CF; Miller, C; Parimi, N; Scalea, TM; Stein, DM; Yang, S, 2018)
"Of the 120 normotensive trauma patients, 30 (25 %) required at least one unit of packed red blood cells (RBC) and 12 (10 %) patients received at least four RBC within the first 48 h."	2.82	Capillary lactate concentration on admission of normotensive trauma patients: a prospective study. ( Bosson, JL; Bouzat, P; Brun, J; Manhes, P; Payen, JF; Schilte, C; Vinclair, M, 2016)
"Shock is a sequelae in trauma and burn patients that substantially increases the risk for morbidity and mortality."	2.82	Utilization and Efficacy of Resuscitation Endpoints in Trauma and Burn Patients: A Review Article. ( Ali, A; Belaunzaran, M; Elkbuli, A; McKenney, M; Newsome, K; Raslan, S, 2022)
"The increasing prevalence of chronic wounds has significant financial implications for nations with advanced healthcare provision."	2.77	The lactate conundrum in wound healing: clinical and experimental findings indicate the requirement for a rapid point-of-care diagnostic. ( Britland, S; Jamil, H; Ross-Smith, O; Smith, AG; Vowden, K; Vowden, P, 2012)
"Because trauma and hemorrhage are the leading causes of noninfectious inflammatory syndromes, the goal of this study was to assess the adrenal reserve of trauma patients and its relation with clinical course."	2.70	Cortisol response to corticotropin stimulation in trauma patients: influence of hemorrhagic shock. ( Asehnoune, K; Benhamou, D; Brailly-Tabard, S; Edouard, AR; Hoen, S; Mazoit, JX; Moine, P, 2002)
"The management of the traumatically injured patient has evolved during the past half century despite continually high morbidity and mortality rates."	2.42	Targeted resuscitation strategies after injury. ( Bilkovski, RN; Horst, HM; Rivers, EP, 2004)
"There were 806 trauma patients recorded in the database."	1.62	Prehospital Blood Pressure and Lactate are Early Predictors of Acute Kidney Injury After Trauma. ( Iwasaki, Y; Kato, S; Kawashima, S; Kunitatsu, K; Nasu, T; Okishio, Y; Ueda, K, 2021)
"In a heterogeneous group of trauma patients, a single copeptin determination at the time of ED admission proved to be an accurate biomarker, statistically superior to lactate for the identification of major trauma, hospital admission, and blood transfusion, while no statistical difference was observed for ICU admission and emergency surgery."	1.56	Serum Copeptin levels in the emergency department predict major clinical outcomes in adult trauma patients. ( Canovi, S; Fasano, T; Ferrari, AM; Franchini, S; Lucchesi, DM; Luppi, F; Polese, A; Salvo, F; Santi, F; Trabucco, L, 2020)
"Development of AKI after blunt trauma is very complex and multifactorial."	1.56	Physiologic risk factors for early acute kidney injury in severely injured patients. ( Bursa, F; Frelich, M; Maca, J; Neiser, J; Petejova, N; Sevcik, P; Sklienka, P; Svagera, Z; Tomaskova, H; Zahorec, R, 2020)
"Among 314 normotensive trauma patients, the area under the receiver operator characteristic curve for PLac predicting need for RC was 0."	1.48	Prehospital Lactate Predicts Need for Resuscitative Care in Non-hypotensive Trauma Patients. ( Bulger, EM; Guyette, FX; McCoy, AM; Moyes, AG; Sayre, MR; St John, AE, 2018)
"In a cohort of trauma patients with a wide spectrum of characteristics triage LAC was statistically able to identify patients at high risk of mortality."	1.48	Clinical value of triage lactate in risk stratifying trauma patients using interval likelihood ratios. ( Baron, BJ; Nguyen, A; Shetty, A; Stefanov, D; Zehtabchi, S, 2018)
"During the 8th week, two wounds were created in the dorsum and collected 10 days later."	1.46	Exercise prior to, but not concomitant with, stress reverses stress-induced delayed skin wound healing. ( Martins, RL; Monte-Alto-Costa, A; Romana-Souza, B; Saguie, BO, 2017)
"The authors evaluated 1,075 trauma patients (mean age, 39 ± 18 yr, with 90% blunt and 10% penetrating injuries and a mortality of 13%)."	1.46	Comparison of the Prognostic Significance of Initial Blood Lactate and Base Deficit in Trauma Patients. ( Baumgarten, R; Duranteau, J; Gauss, T; Hamada, S; Harrois, A; Langeron, O; Le Manach, Y; Mantz, J; Paugam-Burtz, C; Raux, M; Riou, B; Vigue, B, 2017)
"Treatment and management of chronic wounds is a large burden on the health sector and causes substantial suffering for the patients."	1.43	A pilot study investigating lactic acid bacterial symbionts from the honeybee in inhibiting human chronic wound pathogens. ( Butler, É; Lindholm, C; Nilson, B; Oien, RF; Olofsson, TC; Vásquez, A, 2016)
"Twenty-eight percent had trauma center need."	1.43	Prehospital lactate improves accuracy of prehospital criteria for designating trauma activation level. ( Billiar, TR; Brown, JB; Guyette, FX; Lerner, EB; Peitzman, AB; Sperry, JL, 2016)
"In hemodynamically normal trauma patients, the admission lactate of >4 mmol/L is a robust predictor of MT requirement and associated with poor outcomes."	1.43	Lactate predicts massive transfusion in hemodynamically normal patients. ( Brooke, M; Garcia, A; Miraflor, E; Victorino, GP; Yeung, L, 2016)
"Healing of equine wounds, particularly in the limbs, is difficult due to hydrostatic factors and exposure to environmental contaminants, which can lead to heavy bio-burden/biofilm formation and sometimes to infection."	1.43	Fighting Off Wound Pathogens in Horses with Honeybee Lactic Acid Bacteria. ( Butler, É; Lindholm, C; Michanek, P; Nilson, B; Olofsson, TC; Vásquez, A, 2016)
"Rats experiencing trauma did not show major plasma metabolic aberrations."	1.42	Trauma/hemorrhagic shock instigates aberrant metabolic flux through glycolytic pathways, as revealed by preliminary (13)C-glucose labeling metabolomics. ( Bacon, AW; Banerjee, A; D'Alessandro, A; Fragoso, M; Hansen, KC; Moore, EE; Nemkov, T; Peltz, ED; Silliman, CC; Slaughter, AL; Wither, M, 2015)
"In subcutaneous rat wounds, PTK-UR scaffolds supported cellular infiltration and granulation tissue formation, followed first-order degradation kinetics over 7 weeks, and produced significantly greater stenting of subcutaneous wounds compared to PEUR scaffolds."	1.40	A porous tissue engineering scaffold selectively degraded by cell-generated reactive oxygen species. ( Davidson, JM; Duvall, CL; Guelcher, SA; Gupta, MK; Martin, JR; Page, JM; Yu, F, 2014)
"We reviewed all trauma patients between January 2007 and June 2012 in our prospectively maintained database."	1.40	The predictive value of initial serum lactate in trauma patients. ( Bones, K; Joshi, AR; Kaplan, M; Leung, PS; Ortiz, J; Parsikia, A; Strain, J, 2014)
"In full thickness excisional wounds, the treatment with PLGA-LL37 NP significantly accelerated wound healing compared to PLGA or LL37 administration alone."	1.40	PLGA nanoparticles loaded with host defense peptide LL37 promote wound healing. ( Chereddy, KK; Comune, M; Ferreira, LS; Her, CH; Lam, MC; Lopes, A; Moia, C; Porporato, PE; Préat, V; Sonveaux, P; Steinstraesser, L; Vanacker, J; Vandermeulen, G; Zhu, H, 2014)
"We studied a large cohort of trauma patients age ≥ 65 years admitted to a level 1 trauma center from 2009-01-01 - 2011-12-31."	1.39	A retrospective analysis of geriatric trauma patients: venous lactate is a better predictor of mortality than traditional vital signs. ( Bar-Or, D; Bourg, PW; Mains, CW; Offner, PJ; Salottolo, KM, 2013)
"We enrolled 4,742 trauma patients who had an initial lactate measured during a 10-year period."	1.39	Lactate clearance as a predictor of mortality in trauma patients. ( Gupta, A; Howell, MD; Nielsen, VM; Odom, SR; Shapiro, NI; Silva, GS; Talmor, D, 2013)
"The acute coagulopathy of trauma is associated with hypoperfusion, metabolic acidosis and an increased mortality rate."	1.39	Base deficit as an early marker of coagulopathy in trauma. ( Cheddie, S; Hardcastle, TC; Muckart, DJ, 2013)
"Hemorrhagic shock was induced in anesthetized baboons (n = 24) by controlled bleeding (mean arterial pressure, 40 mmHg), base excess (maximum -5 mmol/L), and time (maximum 3 h)."	1.38	Increased circulating D-lactate levels predict risk of mortality after hemorrhage and surgical trauma in baboons. ( Bahrami, S; Hölzenbein, T; Khadem, A; Kröpfl, A; Redl, H; Sobhian, B, 2012)
"The authors evaluated 586 trauma patients (mean age 38±16 yr, 84% blunt and 16% penetrating, mortality 13%)."	1.38	Prognostic significance of blood lactate and lactate clearance in trauma patients. ( Asencio, Y; Devilliers, C; Gaillard, J; Langeron, O; Le Manach, Y; Raux, M; Régnier, MA; Riou, B, 2012)
"Tachycardia is an important early sign of shock in trauma."	1.37	Discrepancy between heart rate and makers of hypoperfusion is a predictor of mortality in trauma patients. ( Ishikawa, K; Matsuoka, T; Mizushima, Y; Ueno, M; Watanabe, H, 2011)
"Elderly trauma patients have worse outcomes than their younger counterparts."	1.37	Mortality risk stratification in elderly trauma patients based on initial arterial lactate and base deficit levels. ( Bricker, SD; Manasrah, R; Nemtsev, D; Neville, AL; Putnam, BA, 2011)
"In blunt trauma patients with positive blood alcohol levels, lactate may be a poor indicator of injury."	1.37	Lactate in trauma: a poor predictor of mortality in the setting of alcohol ingestion. ( Aboutanos, MB; Dechert, TA; Duane, TM; Herbert, HK; Ivatury, RR; Malhotra, AK; Wolfe, L, 2011)
"Non-healing diabetic foot ulcers are characterized by high wound fluid lactate levels."	1.37	Wound fluid lactate concentration: a helpful marker for diagnosing soft-tissue infection in diabetic foot ulcers? Preliminary findings. ( Beckert, S; Bühler, S; Königsrainer, A; Königsrainer, I; Löb, S; Löffler, M; Northoff, H; Symons, S; Weinreich, J; Zieker, D, 2011)
"End points of resuscitation in trauma patients are difficult to define."	1.37	Correlation between IVC dimensions and volume status on CT scan. ( Miraflor, E; Sadjadi, J; Strumwasser, A; Victorino, GP; Yeung, L, 2011)
"We selected trauma patients admitted to a level I trauma center over a 9-year period with SBP between 90 and 110 mmHg."	1.36	Lactate is a better predictor than systolic blood pressure for determining blood requirement and mortality: could prehospital measures improve trauma triage? ( Griffin, RL; Kerby, JD; Rue, LW; Vandromme, MJ; Weinberg, JA, 2010)
"Altogether, 1032 trauma patients (76."	1.35	Early serum procalcitonin, interleukin-6, and 24-hour lactate clearance: useful indicators of septic infections in severely traumatized patients. ( Billeter, A; Keel, M; Mica, L; Seifert, B; Stocker, R; Turina, M, 2009)
"To study this, male rats underwent trauma-hemorrhage (mean blood pressure approximately 40 mmHg for 90 min) followed by fluid resuscitation."	1.35	Mechanism of estrogen-mediated intestinal protection following trauma-hemorrhage: p38 MAPK-dependent upregulation of HO-1. ( Bland, KI; Chaudry, IH; Choudhry, MA; Hsieh, CH; Hsu, JT; Kan, WH; Schwacha, MG, 2008)
"Review of trauma registry data identified 1197 patients between May 2000 and September 2006 who had a trauma-team call out."	1.35	Venous glucose and arterial lactate as biochemical predictors of mortality in clinically severely injured trauma patients--a comparison with ISS and TRISS. ( Caldwell, S; Hill, AG; Kahokehr, A; Sammour, T, 2009)
"In the traumatized area, blood flow, oxygen tension, and pyruvate were similar to the healthy control tissue throughout the experiments, whereas pyruvate was reduced in the ischemic tissue (P < 0."	1.33	The influence of trauma and ischemia on carbohydrate metabolites monitored in hamster flap tissue. ( Banic, A; Contaldo, C; Djonov, V; Erni, D; Leunig, M; Plock, J, 2005)
"Alcohol and drug use are common in trauma, but do not impair the predictive accuracy of admission lactate and BD in trauma outcome."	1.33	Lactate and base deficit in trauma: does alcohol or drug use impair their predictive accuracy? ( Dunne, JR; Napolitano, LM; Scalea, TM; Tracy, JK, 2005)
"Metabolic acidosis is common in patients with cardiac arrest and is conventionally considered to be essentially due to hyperlactatemia."	1.33	A quantitative analysis of the acidosis of cardiac arrest: a prospective observational study. ( Bellomo, R; Makino, J; Morimatsu, H; Uchino, S, 2005)
"When implanted into full-thickness wounds in nude rats, cultured skin equivalents based on PLGA meshes registered a take rate of 100% and showed an extent of wound contraction that was statistically similar to autografts, while wounds grafted with PLGA meshes without cell sheets contracted more than autografts."	1.33	Reduced contraction of skin equivalent engineered using cell sheets cultured in 3D matrices. ( Hutmacher, DW; Ng, KW, 2006)
"Prospective, observational study of trauma patients in a Level 1 trauma center."	1.32	Ethanol and illicit drugs do not affect the diagnostic utility of base deficit and lactate in differentiating minor from major injury in trauma patients. ( Baron, BJ; Lucchesi, M; Sinert, R; Yadav, K; Zehtabchi, S, 2004)
"ISS, Revised Trauma Score, Shock Index, and Trauma and Injury Severity Score were calculated for each subject."	1.32	Relationship between injury severity and lactate levels in severely injured patients. ( Cerović, O; Golubović, V; Kremzar, B; Spec-Marn, A; Vidmar, G, 2003)
"Current pre-hospital trauma triage systems are based mainly on physiological parameters, but in compensated shock injury severity may not be immediately obvious, as the physiological parameters remain normal for some time."	1.31	Early increases in blood lactate following injury. ( Coats, TJ; Lockey, D; Russell, M; Smith, JE, 2002)
"A convenience sample of 47 trauma patients."	1.30	Validation of a hand-held lactate device in determination of blood lactate in critically injured patients. ( Bachl, BL; Ciccone, A; Lavery, RF; Siegel, JH; Slomovitz, BM; Tortella, BJ, 1998)
"In hyperglycemic patients with multiple trauma, hepatic glucose production and gluconeogenesis are increased, suggesting that autoregulation of hepatic glucose production may be defective."	1.29	Effects of lactate on glucose metabolism in healthy subjects and in severely injured hyperglycemic patients. ( Cayeux, MC; Chioléro, R; Jéquier, E; Schindler, C; Schneiter, P; Tappy, L; Temler, E, 1995)

Timeframe	Studies, this research(%)	All Research%
pre-1990	9 (7.09)	18.7374
1990's	12 (9.45)	18.2507
2000's	31 (24.41)	29.6817
2010's	61 (48.03)	24.3611
2020's	14 (11.02)	2.80

Trial	Phase	Enrollment	Study Type	Start Date	Status
Predictive Abilities for Transfusion Needs of Capillary Lactate Measure in Emergency for Injured Normotensive Patients[NCT01793428]		120 participants (Actual)	Observational	2011-08-31	Completed
Evaluation of a Transfusion Therapy Using Whole Blood Versus Fractionated Blood Products in the Management of Coagulopathy in Patients Admitted to Hospital for Acute Traumatic Hemorrhage[NCT04431999]	Phase 3	200 participants (Anticipated)	Interventional	2021-12-04	Recruiting
A Multi-center, Multinational, Randomized, Double-blind, Controlled, Dose Comparison Study to Evaluate Safety and Efficacy of MP4OX Plus Standard Treatment, in Severely Injured Trauma Subjects With Lactic Acidosis Due to Hemorrhagic Shock[NCT01973504]	Phase 2	0 participants (Actual)	Interventional	2013-12-31	Withdrawn (stopped due to Sangart ceased operations)
Fluid Resuscitation Optimization in Surgical Trauma Patients (FROST)[NCT02742974]		196 participants (Anticipated)	Interventional	2015-12-31	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Utilization and Efficacy of Resuscitation Endpoints in Trauma and Burn Patients: A Review Article. The American surgeon, 2022, Volume: 88, Issue:1 Topics: Acid-Base Equilibrium; Bicarbonates; Blood Pressure; Blood Volume; Burns; Heart Rate; Humans; Lactic	2022
The potential of point-of-care diagnostics to optimise prehospital trauma triage: a systematic review of literature. European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2023, Volume: 49, Issue:4 Topics: Brain Injuries, Traumatic; Emergency Medical Services; Humans; Lactic Acid; Point-of-Care Systems; P	2023
Demystifying Lactate in the Emergency Department. Annals of emergency medicine, 2020, Volume: 75, Issue:2 Topics: Acidosis, Lactic; Emergency Service, Hospital; Humans; Hyperlactatemia; Lactic Acid; Prognosis; Seps	2020
Big Tests in Little People. Emergency medicine clinics of North America, 2021, Volume: 39, Issue:3 Topics: Asthma; Biomarkers; Child; Fibrin Fibrinogen Degradation Products; Heart Diseases; Humans; Infection	2021
PLGA based drug delivery systems: Promising carriers for wound healing activity. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 2016, Volume: 24, Issue:2 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Curcumin; Dose-Response Relationship, Drug; Drug C	2016
Is lactate an effective clinical marker of outcome for children with major trauma? - A literature review. International emergency nursing, 2016, Volume: 28 Topics: Adult; Biomarkers; Child; Child, Preschool; Humans; Lactic Acid; Pediatrics; Wounds and Injuries	2016
Tissue Oxygenation Monitoring as a Guide for Trauma Resuscitation. Critical care nurse, 2016, Volume: 36, Issue:3 Topics: Biomarkers; Female; Humans; Injury Severity Score; Lactic Acid; Male; Monitoring, Physiologic; Oxime	2016
Do lactate levels in the emergency department predict outcome in adult trauma patients? A systematic review. The journal of trauma and acute care surgery, 2016, Volume: 81, Issue:3 Topics: Adult; Biomarkers; Emergency Service, Hospital; Hospital Mortality; Humans; Lactic Acid; Outcome Ass	2016
Best Evidence Topic report. BET 2. Serum lactate as a marker for mortality in patients presenting to the emergency department with trauma. Emergency medicine journal : EMJ, 2009, Volume: 26, Issue:2 Topics: Biomarkers; Emergency Service, Hospital; Humans; Lactic Acid; Wounds and Injuries	2009
[Volume replacement in intensive care medicine]. Der Anaesthesist, 2011, Volume: 60, Issue:5 Topics: Blood Pressure; Blood Volume; Cardiomyopathy, Dilated; Cholecystectomy; Colloids; Critical Care; Goa	2011
Trauma and aggressive homeostasis management. Anesthesiology clinics, 2013, Volume: 31, Issue:1 Topics: Acidosis, Lactic; Brain Injuries; Homeostasis; Humans; Hyperglycemia; Hypothermia, Induced; Insulin;	2013
Targeted resuscitation strategies after injury. Current opinion in critical care, 2004, Volume: 10, Issue:6 Topics: Acidosis; Algorithms; Humans; Hydrogen-Ion Concentration; Lactic Acid; Oxygen; Oxygen Consumption; R	2004
Trauma and aggressive homeostasis management. Anesthesiology clinics, 2007, Volume: 25, Issue:1 Topics: Acidosis; Animals; Brain Injuries; Homeostasis; Humans; Hyperglycemia; Hypothermia; Lactic Acid; Sho	2007
Patterns of oxygen transport in trauma and their relationship to outcome. The American journal of emergency medicine, 1994, Volume: 12, Issue:1 Topics: Humans; Inflammation; Lactates; Lactic Acid; Oxygen; Prognosis; Shock; Wounds and Injuries	1994
In search of the optimal end points of resuscitation in trauma patients: a review. The Journal of trauma, 1998, Volume: 44, Issue:5 Topics: Acidosis; Biomarkers; Gastric Mucosa; Humans; Hydrogen-Ion Concentration; Lactic Acid; Oxygen; Resus	1998
Lactate in sepsis and trauma--hindrance or help? Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS, 1999, Volume: 34, Issue:4 Topics: Acidosis, Lactic; Biomarkers; Humans; Lactic Acid; Sepsis; Wounds and Injuries	1999
Lactate is an unreliable indicator of tissue hypoxia in injury or sepsis. Lancet (London, England), 1999, Aug-07, Volume: 354, Issue:9177 Topics: Cell Hypoxia; Humans; Hypoxia; Lactic Acid; Resuscitation; Sensitivity and Specificity; Systemic Inf	1999

Article	Year
Lactate as a mediator of prehospital plasma mortality reduction in hemorrhagic shock. The journal of trauma and acute care surgery, 2021, 07-01, Volume: 91, Issue:1 Topics: Adult; Blood Transfusion; Crystalloid Solutions; Emergency Medical Services; Female; Humans; Injury	2021
Blood Transfusion Indicators Following Trauma in the Non-Massively Bleeding Patient. Annals of clinical and laboratory science, 2018, Volume: 48, Issue:3 Topics: Adolescent; Adult; Aged; Bicarbonates; Biomarkers; Blood Transfusion; Female; Follow-Up Studies; Hem	2018
Trauma induced acute kidney injury. PloS one, 2019, Volume: 14, Issue:1 Topics: Acute Kidney Injury; Adolescent; Adult; Aged; Aged, 80 and over; Blood Pressure; Creatinine; Disease	2019
Utility of admission serum lactate in pediatric trauma. Journal of pediatric surgery, 2015, Volume: 50, Issue:4 Topics: Adolescent; Biomarkers; Child; Child, Preschool; Female; Hospitalization; Humans; Infant; Infant, Ne	2015
Capillary lactate concentration on admission of normotensive trauma patients: a prospective study. Scandinavian journal of trauma, resuscitation and emergency medicine, 2016, Jun-07, Volume: 24 Topics: Adult; Blood Pressure; Erythrocyte Transfusion; Female; Follow-Up Studies; Hemorrhage; Humans; Inpat	2016
The lactate conundrum in wound healing: clinical and experimental findings indicate the requirement for a rapid point-of-care diagnostic. Biotechnology progress, 2012, Volume: 28, Issue:4 Topics: Animals; Colorimetry; Endothelial Cells; Exudates and Transudates; Humans; Lactic Acid; Mice; Wound	2012
Cortisol response to corticotropin stimulation in trauma patients: influence of hemorrhagic shock. Anesthesiology, 2002, Volume: 97, Issue:4 Topics: Adolescent; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Blood Proteins; Female; Hemodynamics	2002
The exchange of blood-borne amino acids in the leg during abdominal surgical trauma: effects of glucose infusion. Clinical science (London, England : 1979), 1986, Volume: 71, Issue:5 Topics: 3-Hydroxybutyric Acid; Adult; Amino Acids; Arteries; Blood Glucose; Cholecystectomy; Female; Glucose	1986

Article	Year
Elevated serum lactate levels and age are associated with an increased risk for severe injury in trauma team activation due to trauma mechanism. European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2022, Volume: 48, Issue:4 Topics: Adult; Humans; Injury Severity Score; Lactic Acid; Retrospective Studies; Trauma Centers; Triage; Wo	2022
Prehospital lactate improves prediction of the need for immediate interventions for hemorrhage after trauma. Scientific reports, 2019, 09-24, Volume: 9, Issue:1 Topics: Adult; Area Under Curve; Blood Transfusion; Emergency Medical Services; Emergency Service, Hospital;	2019
Serum Copeptin levels in the emergency department predict major clinical outcomes in adult trauma patients. BMC emergency medicine, 2020, 02-24, Volume: 20, Issue:1 Topics: Adult; Aged; Biomarkers; Blood Transfusion; Comorbidity; Emergency Service, Hospital; Female; Glycop	2020
Determinants of prehospital lactate in trauma patients: a retrospective cohort study. BMC emergency medicine, 2020, 03-11, Volume: 20, Issue:1 Topics: Aged; Air Ambulances; Blood Pressure; Female; Humans; Lactic Acid; Male; Middle Aged; Oxygen; Retros	2020
Usefulness of the NULL-PLEASE Score to Predict Survival in Out-of-Hospital Cardiac Arrest. The American journal of medicine, 2020, Volume: 133, Issue:11 Topics: Age Factors; Aged; Aged, 80 and over; Cardiopulmonary Resuscitation; Electric Countershock; Female;	2020
Accuracy of prehospital point-of-care lactate in early in-hospital mortality. European journal of clinical investigation, 2020, Volume: 50, Issue:12 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Ambulances; Area Under Curve; Cardiovascular Diseases; E	2020
Admission base deficit is superior to lactate in identifying shock and resuscitative needs in trauma patients. American journal of surgery, 2020, Volume: 220, Issue:6 Topics: Acid-Base Imbalance; Biomarkers; Blood Transfusion; Female; Humans; Injury Severity Score; Lactic Ac	2020
Physiologic risk factors for early acute kidney injury in severely injured patients. Bratislavske lekarske listy, 2020, Volume: 121, Issue:11 Topics: Acute Kidney Injury; Adult; Biomarkers; Humans; Interleukin-6; Lactic Acid; Lipocalin-2; Myoglobin;	2020
Prehospital Blood Pressure and Lactate are Early Predictors of Acute Kidney Injury After Trauma. The Journal of surgical research, 2021, Volume: 265 Topics: Acute Kidney Injury; Adult; Aged; Aged, 80 and over; Blood Pressure; Female; Humans; Japan; Lactic A	2021
Exercise prior to, but not concomitant with, stress reverses stress-induced delayed skin wound healing. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 2017, Volume: 25, Issue:4 Topics: Animals; Behavior, Animal; Cell Differentiation; Collagen; Cytokines; Disease Models, Animal; Granul	2017
Parathyroid hormone as a marker for hypoperfusion in trauma: A prospective observational study. The journal of trauma and acute care surgery, 2017, Volume: 83, Issue:6 Topics: Adult; Aged; Biomarkers; Female; Follow-Up Studies; Humans; Lactic Acid; Male; Middle Aged; Parathyr	2017
Clinical value of triage lactate in risk stratifying trauma patients using interval likelihood ratios. The American journal of emergency medicine, 2018, Volume: 36, Issue:5 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers; Child; Child, Preschool; Female; Hospital Mo	2018
Comparisons of Traditional Metabolic Markers and Compensatory Reserve as Early Predictors of Tolerance to Central Hypovolemia in Humans. Shock (Augusta, Ga.), 2018, Volume: 50, Issue:1 Topics: Adult; Blood Pressure; Female; Heart Rate; Hemodynamics; Hemorrhage; Humans; Hypovolemia; Lactic Aci	2018
All animals are equal but some animals are more equal than others: Plasma lactate and succinate in hemorrhagic shock-A comparison in rodents, swine, nonhuman primates, and injured patients. The journal of trauma and acute care surgery, 2018, Volume: 84, Issue:3 Topics: Animals; Biomarkers; Chromatography, High Pressure Liquid; Disease Models, Animal; Gas Chromatograph	2018
Base deficit is superior to lactate in trauma. American journal of surgery, 2018, Volume: 215, Issue:4 Topics: Acid-Base Imbalance; Biomarkers; Blood Component Transfusion; Blood Gas Analysis; California; Female	2018
Repeat lactate level predicts mortality better than rate of clearance. The American journal of emergency medicine, 2018, Volume: 36, Issue:11 Topics: Adult; Biomarkers; Female; Hospital Mortality; Humans; Lactic Acid; Male; Resuscitation; Retrospecti	2018
Prehospital Lactate Predicts Need for Resuscitative Care in Non-hypotensive Trauma Patients. The western journal of emergency medicine, 2018, Volume: 19, Issue:2 Topics: Adult; Blood Pressure; Emergency Medical Services; Female; Humans; Lactic Acid; Male; Prospective St	2018
Propofol Infusion Syndrome: Efficacy of a Prospective Screening Protocol. The American surgeon, 2018, Aug-01, Volume: 84, Issue:8 Topics: Adult; Clinical Protocols; Creatine Kinase; Critical Care; Female; Humans; Lactic Acid; Length of St	2018
Prognostic value of lactate in prehospital care as a predictor of early mortality. The American journal of emergency medicine, 2019, Volume: 37, Issue:9 Topics: Aged; Aged, 80 and over; Area Under Curve; Cardiovascular Diseases; Critical Illness; Emergency Medi	2019
Activation of Hypoxia-Inducible Factor-1α Via Succinate Dehydrogenase Pathway During Acute Lung Injury Induced by Trauma/Hemorrhagic Shock. Shock (Augusta, Ga.), 2020, Volume: 53, Issue:2 Topics: A549 Cells; Acute Lung Injury; Animals; Blood Gas Analysis; Blotting, Western; Humans; Hypoxia-Induc	2020
A retrospective analysis of geriatric trauma patients: venous lactate is a better predictor of mortality than traditional vital signs. Scandinavian journal of trauma, resuscitation and emergency medicine, 2013, Feb-14, Volume: 21 Topics: Aged; Aged, 80 and over; Biomarkers; Female; Geriatric Nursing; Hospital Mortality; Humans; Lactic A	2013
Lactate clearance as a predictor of mortality in trauma patients. The journal of trauma and acute care surgery, 2013, Volume: 74, Issue:4 Topics: Aged; Biomarkers; Female; Follow-Up Studies; Glasgow Coma Scale; Humans; Lactic Acid; Male; Massachu	2013
Base deficit as an early marker of coagulopathy in trauma. South African journal of surgery. Suid-Afrikaanse tydskrif vir chirurgie, 2013, Jul-31, Volume: 51, Issue:3 Topics: Acidosis; Adolescent; Adult; Aged; Biomarkers; Blood Coagulation Disorders; Child; Child, Preschool;	2013
The effects of tranexamic acid and prothrombin complex concentrate on the coagulopathy of trauma: an in vitro analysis of the impact of severe acidosis. The journal of trauma and acute care surgery, 2013, Volume: 75, Issue:6 Topics: Acidosis; Animals; Antifibrinolytic Agents; Blood Coagulation Disorders; Blood Coagulation Factors;	2013
A proposed novel algorithmic approach to the evaluation of the acutely injured trauma patient: should advanced trauma life support incorporate biomarkers? The American journal of emergency medicine, 2014, Volume: 32, Issue:3 Topics: Advanced Trauma Life Support Care; Algorithms; Biomarkers; Carbon Dioxide; Decision Support Techniqu	2014
A porous tissue engineering scaffold selectively degraded by cell-generated reactive oxygen species. Biomaterials, 2014, Volume: 35, Issue:12 Topics: Animals; Biocompatible Materials; Catalysis; Lactic Acid; Microscopy, Electron, Scanning; Polyglycol	2014
Lactate metabolism in trauma. The journal of trauma and acute care surgery, 2014, Volume: 77, Issue:1 Topics: Female; Humans; Lactic Acid; Male; Registries; Trauma Centers; Wounds and Injuries	2014
Lactate clearance as a predictor of mortality. The journal of trauma and acute care surgery, 2014, Volume: 77, Issue:1 Topics: Female; Humans; Lactic Acid; Male; Registries; Trauma Centers; Wounds and Injuries	2014
Re: lactate clearance as a predictor of mortality. The journal of trauma and acute care surgery, 2014, Volume: 77, Issue:1 Topics: Female; Humans; Lactic Acid; Male; Registries; Trauma Centers; Wounds and Injuries	2014
The predictive value of initial serum lactate in trauma patients. Shock (Augusta, Ga.), 2014, Volume: 42, Issue:3 Topics: Adult; Aged; Area Under Curve; Biomarkers; Chi-Square Distribution; Databases, Factual; Female; Hosp	2014
PLGA nanoparticles loaded with host defense peptide LL37 promote wound healing. Journal of controlled release : official journal of the Controlled Release Society, 2014, Nov-28, Volume: 194 Topics: Animals; Anti-Bacterial Agents; Antimicrobial Cationic Peptides; Cathelicidins; Cell Movement; Colla	2014
A pilot study investigating lactic acid bacterial symbionts from the honeybee in inhibiting human chronic wound pathogens. International wound journal, 2016, Volume: 13, Issue:5 Topics: Adult; Aged; Aged, 80 and over; Animals; Anti-Infective Agents; Antibiosis; Bacteria; Bees; Biologic	2016
The effect of ethanol on lactate and base deficit as predictors of morbidity and mortality in trauma. The American journal of emergency medicine, 2015, Volume: 33, Issue:5 Topics: Acid-Base Imbalance; Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers; Ethanol; Female; Hospit	2015
Prehospital point-of-care monitoring and goal-directed therapy: Does it make a difference? The journal of trauma and acute care surgery, 2015, Volume: 78, Issue:6 Suppl 1 Topics: Emergency Medical Services; Fibrinogen; Humans; Lactic Acid; Monitoring, Ambulatory; Point-of-Care S	2015
Trauma/hemorrhagic shock instigates aberrant metabolic flux through glycolytic pathways, as revealed by preliminary (13)C-glucose labeling metabolomics. Journal of translational medicine, 2015, Aug-05, Volume: 13 Topics: Animals; Carbon; Glycolysis; Isotope Labeling; Lactic Acid; Metabolic Flux Analysis; Metabolomics; R	2015
Twenty-four-hour packed red blood cell requirement is the strongest independent prognostic marker of mortality in ED trauma patients. The American journal of emergency medicine, 2016, Volume: 34, Issue:6 Topics: Adult; Erythrocyte Transfusion; Female; Humans; Injury Severity Score; Lactic Acid; Male; Prognosis;	2016
Prehospital lactate improves accuracy of prehospital criteria for designating trauma activation level. The journal of trauma and acute care surgery, 2016, Volume: 81, Issue:3 Topics: Adult; Air Ambulances; Algorithms; Biomarkers; Emergency Medical Services; Female; Health Services N	2016
Fighting Off Wound Pathogens in Horses with Honeybee Lactic Acid Bacteria. Current microbiology, 2016, Volume: 73, Issue:4 Topics: Animals; Bees; Bifidobacterium; Biological Therapy; Honey; Horse Diseases; Horses; Lactic Acid; Lact	2016
Lactate predicts massive transfusion in hemodynamically normal patients. The Journal of surgical research, 2016, Volume: 204, Issue:1 Topics: Adult; Biomarkers; Blood Transfusion; Female; Hemodynamics; Hemorrhage; Humans; Lactic Acid; Logisti	2016
Comparison of the Prognostic Significance of Initial Blood Lactate and Base Deficit in Trauma Patients. Anesthesiology, 2017, Volume: 126, Issue:3 Topics: Academic Medical Centers; Acid-Base Imbalance; Adult; Biomarkers; Cohort Studies; Female; France; Ho	2017
Venous glucose and arterial lactate as biochemical predictors of mortality in clinically severely injured trauma patients--a comparison with ISS and TRISS. Injury, 2009, Volume: 40, Issue:1 Topics: Adult; Biomarkers; Blood Glucose; Female; Humans; Injury Severity Score; Lactic Acid; Male; Prognosi	2009
Early serum procalcitonin, interleukin-6, and 24-hour lactate clearance: useful indicators of septic infections in severely traumatized patients. World journal of surgery, 2009, Volume: 33, Issue:3 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers; C-Reactive Protein; Calcitonin; Calcitonin G	2009
Tissue healing during degradation of a long-lasting bioresorbable gamma-ray-sterilised poly(lactic acid) mesh in the rat: a 12-month study. European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 2010, Volume: 44, Issue:2 Topics: Animals; Disinfection; Gamma Rays; Hernia, Abdominal; Inflammation; Lactic Acid; Membranes, Artifici	2010
Diaspirin cross-linked hemoglobin infusion did not influence base deficit and lactic acid levels in two clinical trials of traumatic hemorrhagic shock patient resuscitation. The Journal of trauma, 2010, Volume: 68, Issue:5 Topics: Acidosis, Lactic; Adult; Aspirin; Emergency Medical Services; Emergency Treatment; Europe; Fluid The	2010
Lactate is a better predictor than systolic blood pressure for determining blood requirement and mortality: could prehospital measures improve trauma triage? Journal of the American College of Surgeons, 2010, Volume: 210, Issue:5 Topics: Adult; Blood Pressure; Cohort Studies; Erythrocyte Transfusion; Female; Humans; Lactic Acid; Male; P	2010
Tracheal defect repair using a PLGA-collagen hybrid scaffold reinforced by a copolymer stent with bFGF-impregnated gelatin hydrogel. Pediatric surgery international, 2010, Volume: 26, Issue:6 Topics: Animals; Biocompatible Materials; Biomechanical Phenomena; Cartilage; Collagen; Disease Models, Anim	2010
Comparison of lactate, base excess, bicarbonate, and pH as predictors of mortality after severe trauma in rhesus macaques (Macaca mulatta). Comparative medicine, 2010, Volume: 60, Issue:3 Topics: Acid-Base Equilibrium; Acidosis; Animals; Bicarbonates; Biomarkers; Female; Housing, Animal; Hydroge	2010
1H-NMR-based metabolic signatures of clinical outcomes in trauma patients--beyond lactate and base deficit. The Journal of trauma, 2010, Volume: 69, Issue:1 Topics: Adult; Biomarkers; Blood Glucose; Fatty Acids, Monounsaturated; Female; Glutamic Acid; Humans; Hydro	2010
An implantable biochip to influence patient outcomes following trauma-induced hemorrhage. Analytical and bioanalytical chemistry, 2011, Volume: 399, Issue:1 Topics: Animals; Biosensing Techniques; Disease Models, Animal; Enzymes, Immobilized; Glucose; Glucose Oxida	2011
A G-CSF functionalized PLLA scaffold for wound repair: An in vitro preliminary study. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2010, Volume: 2010 Topics: Animals; Drug Implants; Equipment Design; Equipment Failure Analysis; Granulocyte Colony-Stimulating	2010
Wound fluid lactate concentration: a helpful marker for diagnosing soft-tissue infection in diabetic foot ulcers? Preliminary findings. Diabetic medicine : a journal of the British Diabetic Association, 2011, Volume: 28, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Amputation, Surgical; Biomarkers; Body Fluids; Diabetes Mellitus, Ty	2011
Prospective identification of patients at risk for massive transfusion: an imprecise endeavor. The American surgeon, 2011, Volume: 77, Issue:2 Topics: Adult; Blood Pressure; Blood Transfusion; Emergency Service, Hospital; Erythrocyte Transfusion; Hear	2011
Correlation between IVC dimensions and volume status on CT scan. The Journal of surgical research, 2011, Volume: 170, Issue:2 Topics: Adult; Aged; Blood Volume; Blood Volume Determination; Databases, Factual; Female; Humans; Lactic Ac	2011
Prehospital serum lactate as a predictor of outcomes in trauma patients: a retrospective observational study. The Journal of trauma, 2011, Volume: 70, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Emergency Medical Services; Female; Follow-Up Studies; H	2011
Discrepancy between heart rate and makers of hypoperfusion is a predictor of mortality in trauma patients. The Journal of trauma, 2011, Volume: 71, Issue:4 Topics: Acidosis, Lactic; Adult; Blood Pressure; Heart Rate; Humans; Injury Severity Score; Lactic Acid; Log	2011
Mortality risk stratification in elderly trauma patients based on initial arterial lactate and base deficit levels. The American surgeon, 2011, Volume: 77, Issue:10 Topics: Acid-Base Imbalance; Aged; Aged, 80 and over; Area Under Curve; Biomarkers; California; Female; Hosp	2011
Increased circulating D-lactate levels predict risk of mortality after hemorrhage and surgical trauma in baboons. Shock (Augusta, Ga.), 2012, Volume: 37, Issue:5 Topics: Animals; Colon; Disease Models, Animal; Humans; Ischemia; Lactic Acid; Male; Papio ursinus; Risk Fac	2012
Lactate in trauma: a poor predictor of mortality in the setting of alcohol ingestion. The American surgeon, 2011, Volume: 77, Issue:12 Topics: Acid-Base Equilibrium; Adult; Alcohol Drinking; Biomarkers; Female; Follow-Up Studies; Humans; Lacti	2011
The effect of osteochondral regeneration using polymer constructs and continuous passive motion therapy in the lower weight-bearing zone of femoral trocheal groove in rabbits. Annals of biomedical engineering, 2013, Volume: 41, Issue:2 Topics: Animals; Bone Regeneration; Femur; Knee Injuries; Lactic Acid; Male; Movement; Polyglycolic Acid; Po	2013
Lactate clearance in the acutely traumatized patient. Anesthesiology, 2012, Volume: 117, Issue:6 Topics: Female; Humans; Injury Severity Score; Lactic Acid; Male; Wounds and Injuries	2012
Prognostic significance of blood lactate and lactate clearance in trauma patients. Anesthesiology, 2012, Volume: 117, Issue:6 Topics: Adult; Aged; Biomarkers; Cohort Studies; Female; Humans; Injury Severity Score; Lactic Acid; Male; M	2012
Prognostic significance of blood lactate and lactate clearance in trauma patients. Anesthesiology, 2012, Volume: 117, Issue:6 Topics: Adult; Aged; Biomarkers; Cohort Studies; Female; Humans; Injury Severity Score; Lactic Acid; Male; M	2012
Prognostic significance of blood lactate and lactate clearance in trauma patients. Anesthesiology, 2012, Volume: 117, Issue:6 Topics: Adult; Aged; Biomarkers; Cohort Studies; Female; Humans; Injury Severity Score; Lactic Acid; Male; M	2012
Prognostic significance of blood lactate and lactate clearance in trauma patients. Anesthesiology, 2012, Volume: 117, Issue:6 Topics: Adult; Aged; Biomarkers; Cohort Studies; Female; Humans; Injury Severity Score; Lactic Acid; Male; M	2012
Early increases in blood lactate following injury. Journal of the Royal Army Medical Corps, 2002, Volume: 148, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Blood Chemical Analysis; Emergency Medical Services; Humans; Injury	2002
Preliminary biocompatibility experiment of polymer films for laser-assisted tissue welding. Lasers in surgery and medicine, 2003, Volume: 32, Issue:3 Topics: Animals; Biocompatible Materials; Disease Models, Animal; Female; Lactic Acid; Laser Coagulation; Ma	2003
Relationship between injury severity and lactate levels in severely injured patients. Intensive care medicine, 2003, Volume: 29, Issue:8 Topics: Adult; Aged; Critical Care; Humans; Injury Severity Score; Lactic Acid; Middle Aged; Prospective Stu	2003
[Antagonistic value of living lactic acid bacteria in therapy of infected wounds]. Arztliche Wochenschrift, 1953, Jan-30, Volume: 8, Issue:5 Topics: Humans; Lactic Acid; Lactobacillus; Life; Psychotherapy; Wound Infection; Wounds and Injuries	1953
[Surgical experiences with a preparation of pure cultures of lactic acid bacteria]. Medizinische Klinik, 1953, Sep-18, Volume: 48, Issue:38 Topics: Humans; Lactic Acid; Lactobacillus; Wounds and Injuries	1953
[Modifications of lactic and pyruvic acids in the blood and cerebrospinal fluid in cranial trauma]. Rivista di medicina aeronautica, 1952, Volume: 15, Issue:4 Topics: Blood; Cerebrospinal Fluid; Craniocerebral Trauma; Humans; Lactic Acid; Pyruvates; Pyruvic Acid; Wou	1952
Neuromuscular rehabilitation by treadmill running or electrical stimulation after peripheral nerve injury and repair. Journal of applied physiology (Bethesda, Md. : 1985), 2004, Volume: 96, Issue:5 Topics: Action Potentials; Animals; Axons; Electric Stimulation; Female; Injections; Lactic Acid; Motor Acti	2004
Patients with impending abdominal compartment syndrome do not respond to early volume loading. American journal of surgery, 2003, Volume: 186, Issue:6 Topics: Abdomen; Acid-Base Imbalance; Adult; Blood Transfusion; Compartment Syndromes; Crystalloid Solutions	2003
Oxygen 2002: wounds. Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc, 2004,Spring, Volume: 31, Issue:1 Topics: Bacterial Infections; Biomedical Research; Cell Hypoxia; Growth Substances; Humans; Hyperbaric Oxyge	2004
Ethanol and illicit drugs do not affect the diagnostic utility of base deficit and lactate in differentiating minor from major injury in trauma patients. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2004, Volume: 11, Issue:10 Topics: Acid-Base Imbalance; Adolescent; Adult; Age Distribution; Aged; Aged, 80 and over; Emergency Medicin	2004
Cerebral vascular and metabolic response to sustained systemic inflammation in ovine traumatic brain injury. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2004, Volume: 24, Issue:12 Topics: Animals; Blood Glucose; Body Temperature; Brain; Brain Injuries; Carbon Dioxide; Cerebrovascular Cir	2004
Strong ion gap. Critical care medicine, 2005, Volume: 33, Issue:1 Topics: Acid-Base Equilibrium; Acute Kidney Injury; Adult; Blood Vessels; Critical Care; Hospital Mortality;	2005
The influence of trauma and ischemia on carbohydrate metabolites monitored in hamster flap tissue. Anesthesia and analgesia, 2005, Volume: 100, Issue:3 Topics: Animals; Carbohydrate Metabolism; Cricetinae; Ischemia; Lactic Acid; Male; Mesocricetus; Oxygen; Pyr	2005
Lactate and base deficit in trauma: does alcohol or drug use impair their predictive accuracy? The Journal of trauma, 2005, Volume: 58, Issue:5 Topics: Acid-Base Imbalance; Adult; Age Distribution; Alcohol Drinking; Biomarkers; Cocaine-Related Disorder	2005
A quantitative analysis of the acidosis of cardiac arrest: a prospective observational study. Critical care (London, England), 2005, Volume: 9, Issue:4 Topics: Acidosis; Adult; Chlorides; Comorbidity; Female; Heart Arrest; Humans; Lactic Acid; Male; Middle Age	2005
Diagnostic performance of serial haematocrit measurements in identifying major injury in adult trauma patients. Injury, 2006, Volume: 37, Issue:1 Topics: Adult; Female; Hematocrit; Hemorrhage; Humans; Infusions, Intravenous; Injury Severity Score; Lactic	2006
Admission serum lactate levels do not predict mortality in the acutely injured patient. The Journal of trauma, 2006, Volume: 60, Issue:3 Topics: Adult; California; Data Interpretation, Statistical; Female; Hospital Mortality; Humans; Injury Seve	2006
Reduced contraction of skin equivalent engineered using cell sheets cultured in 3D matrices. Biomaterials, 2006, Volume: 27, Issue:26 Topics: Animals; Cell Culture Techniques; Collagen; Dermatologic Surgical Procedures; Fibroblasts; Glycolate	2006
Broken or dislodged poly-L-lactic acid bioabsorbable tacks in patients after SLAP lesion surgery. Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association, 2006, Volume: 22, Issue:6 Topics: Absorbable Implants; Adult; Arthroscopy; Bone Nails; Device Removal; Equipment Failure; Humans; Lact	2006
Is blood sugar the next lactate? The American surgeon, 2006, Volume: 72, Issue:7 Topics: Adult; Age Factors; Bacterial Infections; Blood Glucose; Cause of Death; Craniocerebral Trauma; Crit	2006
Utility of Stewart's strong ion difference as a predictor of major injury after trauma in the ED. The American journal of emergency medicine, 2007, Volume: 25, Issue:8 Topics: Acid-Base Imbalance; Acidosis; Adolescent; Adult; Aged; Aged, 80 and over; Bicarbonates; Emergency S	2007
Comparison of acid-base models for prediction of hospital mortality after trauma. Shock (Augusta, Ga.), 2008, Volume: 29, Issue:6 Topics: Acidosis, Lactic; Adult; Bicarbonates; Biomarkers; Female; Hospital Mortality; Humans; Hydrogen-Ion	2008
Mechanism of estrogen-mediated intestinal protection following trauma-hemorrhage: p38 MAPK-dependent upregulation of HO-1. American journal of physiology. Regulatory, integrative and comparative physiology, 2008, Volume: 294, Issue:6 Topics: Animals; Chemokine CXCL1; Chemokine CXCL2; Estrogens; Heme Oxygenase-1; Hemorrhage; Intercellular Ad	2008
[Effect of stress and nutrition on metabolism]. Zhonghua yi xue za zhi, 1983, Volume: 63, Issue:11 Topics: Animals; Fatty Acids, Nonesterified; Ketone Bodies; Lactates; Lactic Acid; Nutritional Physiological	1983
Effects of lactate on glucose metabolism in healthy subjects and in severely injured hyperglycemic patients. The American journal of physiology, 1995, Volume: 268, Issue:4 Pt 1 Topics: Adolescent; Adult; Aged; Blood Glucose; Critical Illness; Energy Metabolism; Female; Glucose; Homeos	1995
Changes in regulators of circulation in patients undergoing continuous pump-driven veno-venous hemofiltration. Shock (Augusta, Ga.), 1994, Volume: 2, Issue:3 Topics: Acute Kidney Injury; Atrial Natriuretic Factor; Blood Circulation; Blood Pressure; Creatinine; Dopam	1994
Early hormonal changes affect the catabolic response to trauma. Annals of surgery, 1993, Volume: 218, Issue:4 Topics: Adult; Amino Acids; Blood Glucose; Calorimetry; Epinephrine; Female; Glucagon; Humans; Hydrocortison	1993
Validation of a hand-held lactate device in determination of blood lactate in critically injured patients. Critical care medicine, 1998, Volume: 26, Issue:9 Topics: Adolescent; Adult; Aged; Critical Care; Female; Humans; Lactic Acid; Linear Models; Male; Middle Age	1998
Elevated arterial base deficit in trauma patients: a marker of impaired oxygen utilization. Journal of the American College of Surgeons, 1998, Volume: 187, Issue:4 Topics: Acid-Base Imbalance; Adult; Aged; Cell Respiration; Female; Hemodynamics; Humans; Lactic Acid; Linea	1998
Elevated arterial base deficit. Journal of the American College of Surgeons, 1999, Volume: 188, Issue:3 Topics: Acid-Base Imbalance; Arteries; Humans; Lactic Acid; Oxygen Consumption; Time Factors; Wounds and Inj	1999
Novel living skin replacement biotherapy approach for wounded skin tissues. Tissue engineering, 1999, Volume: 5, Issue:2 Topics: Animals; Biocompatible Materials; Cell Movement; Cell Survival; Cell Transplantation; Cells, Culture	1999
Biodegradable polymer film reinforcement of an indocyanine green-doped liquid albumin solder for laser-assisted incision closure. Lasers in surgery and medicine, 2000, Volume: 27, Issue:1 Topics: Animals; Aorta, Thoracic; Biocompatible Materials; Biodegradation, Environmental; Cattle; Indocyanin	2000
Taurine and pulmonary hemodynamics in sepsis. Amino acids, 2000, Volume: 18, Issue:4 Topics: Adolescent; Adult; Amino Acids; Atrial Function, Right; Blood Pressure; Female; Hemodynamics; Humans	2000
Novel solid protein solder designs for laser-assisted tissue repair. Lasers in surgery and medicine, 2000, Volume: 27, Issue:2 Topics: Animals; Aorta, Thoracic; Biocompatible Materials; Cattle; Coloring Agents; Feasibility Studies; In	2000
Preventive effect of glutamine on intestinal barrier dysfunction induced by severe trauma. World journal of gastroenterology, 2002, Volume: 8, Issue:1 Topics: Amine Oxidase (Copper-Containing); Animals; Endotoxemia; Endotoxins; Glutamine; Intestinal Absorptio	2002
Complications in the first 1,043 operations where self-reinforced poly-L-lactide implants were used solely for tissue fixation in orthopaedics and traumatology. International orthopaedics, 2002, Volume: 26, Issue:2 Topics: Absorbable Implants; Adult; Female; Fracture Fixation; Humans; Lactic Acid; Male; Middle Aged; Ortho	2002
Effect of catabolic hormone infusion on protein turnover and amino acid uptake in skeletal muscle. American journal of surgery, 1990, Volume: 159, Issue:3 Topics: Amino Acids; Aminobutyrates; Animals; Blood Glucose; Epinephrine; Glucagon; Hormones; Hydrocortisone	1990
Serum osmolar and electrolyte changes associated with hypertonic resuscitation. Progress in clinical and biological research, 1989, Volume: 299 Topics: Aorta; Burns; Electrolytes; Fluid Therapy; Humans; Hypertonic Solutions; Isotonic Solutions; Lactate	1989
[Biochemical measurements of glucose metabolism in relation to cause of death and postmortem effects]. Zeitschrift fur Rechtsmedizin. Journal of legal medicine, 1986, Volume: 96, Issue:3 Topics: Acetone; Blood Glucose; Diabetes Mellitus; Diabetic Coma; Glycated Hemoglobin; Hemorrhage; Humans; L	1986
The relationship of plasma catecholamines to acute metabolic and hormonal responses to injury in man. Circulatory shock, 1985, Volume: 16, Issue:3 Topics: Adolescent; Adult; Aged; Blood Glucose; Dopamine; Epinephrine; Ethanol; Fatty Acids, Nonesterified;	1985
[Multiple injury and severe multiple injury (remarks on definition and pathophysiology]. Zeitschrift fur arztliche Fortbildung, 1985, Volume: 79, Issue:22 Topics: Abdominal Injuries; Adolescent; Adult; Aged; Blood Coagulation Factors; Brain Injuries; Child; Child	1985

lactic acid and Injuries

Research Excerpts

Research

Studies (127)

Authors

Clinical Trials (4)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Hagebusch, P	1
Faul, P	1
Klug, A	1
Gramlich, Y	1
Hoffmann, R	1
Schweigkofler, U	1
Belaunzaran, M	1
Raslan, S	1
Ali, A	1
Newsome, K	1
McKenney, M	1
Elkbuli, A	1
Stojek, L	1
Bieler, D	1
Neubert, A	1
Ahnert, T	1
Imach, S	1
Wardi, G	1
Brice, J	1
Correia, M	1
Liu, D	1
Self, M	1
Tainter, C	1
Fukuma, H	1
Nakada, TA	1
Shimada, T	1
Shimazui, T	1
Aizimu, T	1
Nakao, S	1
Watanabe, H	2
Mizushima, Y	2
Matsuoka, T	2
Salvo, F	1
Luppi, F	1
Lucchesi, DM	1
Canovi, S	1
Franchini, S	1
Polese, A	1
Santi, F	1
Trabucco, L	1
Fasano, T	1
Ferrari, AM	1
Ter Avest, E	1
Griggs, J	1
Wijesuriya, J	1
Russell, MQ	1
Lyon, RM	1
Gue, YX	1
Sayers, M	1
Whitby, BT	1
Kanji, R	1
Adatia, K	1
Smith, R	1
Davies, WR	1
Perperoglou, A	1
Potpara, TS	1
Lip, GYH	1
Gorog, DA	1
Martín-Rodríguez, F	2
López-Izquierdo, R	2
Medina-Lozano, E	1
Ortega Rabbione, G	1
Del Pozo Vegas, C	2
Carbajosa Rodríguez, V	1
Castro Villamor, MÁ	2
Sánchez-Soberon, I	1
Sanz-García, A	1
Davis, JW	3
Sue, LP	1
Dirks, RC	2
Kaups, KL	2
Kwok, AM	1
Wolfe, MM	1
Lilienstein, JT	1
Bilello, JF	1
Sklienka, P	1
Maca, J	1
Neiser, J	1
Bursa, F	1
Sevcik, P	1
Frelich, M	1
Petejova, N	1
Svagera, Z	1
Tomaskova, H	1
Zahorec, R	1
Canton, SP	1
Lutfi, W	1
Daley, BJ	1
Miller, RS	1
Harbrecht, BG	1
Claridge, JA	1
Phelan, HA	1
Guyette, FX	3
Sperry, JL	2
Brown, JB	2
Nasu, T	1
Ueda, K	1
Kawashima, S	1
Okishio, Y	1
Kunitatsu, K	1
Iwasaki, Y	1
Kato, S	1
Guyther, J	1
Cantwell, L	1
Saguie, BO	1
Romana-Souza, B	1
Martins, RL	1
Monte-Alto-Costa, A	1
Fligor, SC	1
Love, KM	1
Collier, BR	1
Lollar, DI	1
Hamill, ME	1
Benson, AD	1
Bradburn, EH	1
Baron, BJ	2
Nguyen, A	1
Stefanov, D	1
Shetty, A	1
Zehtabchi, S	4
Schiller, AM	1
Howard, JT	1
Lye, KR	1
Magby, CG	1
Convertino, VA	1
Reisz, JA	1
Wither, MJ	1
Moore, EE	2
Slaughter, AL	2
Moore, HB	1
Ghasabyan, A	1
Chandler, J	1
Schaub, LJ	1
Fragoso, M	2
Nunns, G	1
Silliman, CC	2
Hansen, KC	2
Banerjee, A	2
Sheppard, FR	1
D'Alessandro, A	2
Tran, P	1
Dezman, ZDW	1
Comer, AC	1
Smith, GS	1
Hu, PF	2
Mackenzie, CF	2
Scalea, TM	3
Hirshon, JM	1
St John, AE	1
McCoy, AM	1
Moyes, AG	1
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Ferguson, MD	1
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