lactic acid has been researched along with Infarction, Middle Cerebral Artery in 42 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Infarction, Middle Cerebral Artery: NECROSIS occurring in the MIDDLE CEREBRAL ARTERY distribution system which brings blood to the entire lateral aspects of each CEREBRAL HEMISPHERE. Clinical signs include impaired cognition; APHASIA; AGRAPHIA; weak and numbness in the face and arms, contralaterally or bilaterally depending on the infarction.
Excerpt | Relevance | Reference |
---|---|---|
"To study the protective effects of lycopene (LP) on cerebral ischemia-reperfusion injury induced by focal cerebral ischemia and oxidative stress in rats." | 7.76 | [The effects of lycopene on reactive oxygen species and anoxic damage in ischemia reperfusion injury in rats]. ( Mai, JY; Shen, H; Shen, XN; Wang, RZ; Wei, Y; Wu, M, 2010) |
"Osmotic agents such as glycerol are used to treat brain edema in stroke patients." | 7.73 | Neurochemical monitoring of glycerol therapy in patients with ischemic brain edema. ( Berger, C; Kiening, KL; Sakowitz, OW; Schwab, S, 2005) |
" Here we sought to identify whether the enhanced lactic acidosis and increased expression of monocarboxylate transporters (MCTs) observed after stroke might be attenuated by single and/or combined EtOH and NBO therapies." | 3.81 | Reduced cerebral monocarboxylate transporters and lactate levels by ethanol and normobaric oxygen therapy in severe transient and permanent ischemic stroke. ( Brogan, D; Cai, L; Ding, Y; Du, H; Geng, X; Ji, X; Kwiecien, TD; Peng, C; Rafols, JA; Rastogi, R; Singh, S; Sy, CA, 2015) |
"To study the protective effects of lycopene (LP) on cerebral ischemia-reperfusion injury induced by focal cerebral ischemia and oxidative stress in rats." | 3.76 | [The effects of lycopene on reactive oxygen species and anoxic damage in ischemia reperfusion injury in rats]. ( Mai, JY; Shen, H; Shen, XN; Wang, RZ; Wei, Y; Wu, M, 2010) |
"Osmotic agents such as glycerol are used to treat brain edema in stroke patients." | 3.73 | Neurochemical monitoring of glycerol therapy in patients with ischemic brain edema. ( Berger, C; Kiening, KL; Sakowitz, OW; Schwab, S, 2005) |
"NAA/choline (Cho) ratios were significantly reduced in both areas of T2 hyperintensity and in surrounding tissue." | 2.70 | Spectroscopic data following stroke reveal tissue abnormality beyond the region of T2-weighted hyperintensity. ( Beley, A; Brunotte, F; Demougeot, C; Giroud, M; Marie, C; Rouaud, O; Walker, P, 2002) |
"Stroke is the main cause of acquired disability in adults." | 1.91 | Pre-stroke exercise does not reduce atrophy in healthy young adult mice. ( Brox, C; Christiansen, CL; Doosje, HL; Geiseler, SJ; Liesz, A; Morland, C; Nguyen, TD; Phan, KD; Tartanoglu, C, 2023) |
"Rats were subjected to transitory middle cerebral artery occlusion (MCAO) or kainic acid (KA) preconditioning protocol respectively, followed by KA induced epilepsy or lethal MCAO as well as lactate transportation inhibitor injection, with a subsequent evaluation of behavior and infarct volume as well as MCTs expression in rats brain." | 1.51 | Involvement of monocarboxylate transporters in the cross-tolerance between epilepsy and cerebral infarction: A promising choice towards new treatments. ( Bai, J; Gao, C; Gao, L; Li, Z; Wang, R, 2019) |
" In the present study, neuroprotective properties of creatylglycine ethyl ester fumarate (CrGEt) in rats with focal cerebral ischemia were explored in a wide dosage range (30-280 mg/kg, intravenous and intragastric)." | 1.42 | Neuroprotective activity of creatylglycine ethyl ester fumarate. ( Barygin, OI; Isaeva, AV; Korzhevskii, DE; Morozov, VA; Portsel, MN; Tihonov, DB; Veselkina, OS; Vlasov, TD, 2015) |
"Stroke was induced by permanent middle cerebral artery occlusion in rats." | 1.38 | Novel MRI detection of the ischemic penumbra: direct assessment of metabolic integrity. ( Deuchar, GA; Gallagher, L; Holmes, WM; Lopez-Gonzalez, MR; Macrae, IM; Santosh, C, 2012) |
"Glycerol concentration was significantly lower in patients treated by hypothermia (111 +/- 17 micromol/l; P < 0." | 1.35 | Neurochemical monitoring of therapeutic effects in large human MCA infarction. ( Berger, C; Kiening, K; Schwab, S, 2008) |
"Transient (2 hours) middle cerebral artery occlusion (MCAO) was performed in eight macaque monkeys." | 1.33 | Relationship between cerebral blood flow and oxygen metabolism, and extracellular glucose and lactate concentrations during middle cerebral artery occlusion and reperfusion: a microdialysis and positron emission tomography study in nonhuman primates. ( Enblad, P; Frykholm, P; Hillered, L; Långström, B; Persson, L; Valtysson, J, 2005) |
"Regarding MCA infarction, contralateral tissue remote from the lesion behaves abnormally in the presence of hypertension, the NAA ratios in hypertensive patients being significantly lower." | 1.33 | Is NAA reduction in normal contralateral cerebral tissue in stroke patients dependent on underlying risk factors? ( Ben Salem, D; Brunotte, F; Giroud, M; Walker, PM, 2006) |
"A case of cerebral infarction with transient cerebral arteriopathy in a 12-year-old female is described." | 1.32 | MR imaging and 1H-MR spectroscopy in a case of cerebral infarction with transient cerebral arteriopathy. ( Ariki, M; Hattori, T; Horikoshi, H; Imamura, A; Matsuo, N, 2004) |
"Transorbital 2 hour middle cerebral artery occlusion (MCAO) was performed in eight monkeys, which were studied with continuous microdialysis for 24 hours." | 1.31 | Increase of interstitial glycerol reflects the degree of ischaemic brain damage: a PET and microdialysis study in a middle cerebral artery occlusion-reperfusion primate model. ( Enblad, P; Frykholm, P; Hillered, L; Långström, B; Persson, L; Valtysson, J; Watanabe, Y, 2001) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 22 (52.38) | 29.6817 |
2010's | 16 (38.10) | 24.3611 |
2020's | 4 (9.52) | 2.80 |
Authors | Studies |
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Xu, J | 1 |
Ji, T | 1 |
Li, G | 1 |
Zhang, H | 1 |
Zheng, Y | 1 |
Li, M | 1 |
Ma, J | 1 |
Li, Y | 1 |
Chi, G | 1 |
Bhatti, MS | 1 |
Frostig, RD | 1 |
Geiseler, SJ | 1 |
Phan, KD | 1 |
Brox, C | 1 |
Nguyen, TD | 1 |
Tartanoglu, C | 1 |
Doosje, HL | 1 |
Christiansen, CL | 1 |
Liesz, A | 1 |
Morland, C | 1 |
Hyacinthe, JN | 1 |
Buscemi, L | 1 |
Lê, TP | 1 |
Lepore, M | 1 |
Hirt, L | 4 |
Mishkovsky, M | 1 |
Deuchar, GA | 2 |
Brennan, D | 1 |
Holmes, WM | 2 |
Shaw, M | 1 |
Macrae, IM | 2 |
Santosh, C | 2 |
Gao, C | 1 |
Li, Z | 1 |
Bai, J | 1 |
Wang, R | 1 |
Gao, L | 1 |
Ju, R | 1 |
Wen, Y | 1 |
Gou, R | 1 |
Wang, Y | 2 |
Xu, Q | 1 |
Shen, Z | 1 |
Jiang, L | 1 |
Yuan, Y | 1 |
Deng, T | 1 |
Zheng, YR | 1 |
Zhao, YY | 1 |
Li, WL | 1 |
Wu, JY | 1 |
Gao, JQ | 1 |
Hu, WW | 1 |
Zhang, XN | 1 |
Chen, Z | 1 |
Veselkina, OS | 1 |
Morozov, VA | 1 |
Korzhevskii, DE | 1 |
Tihonov, DB | 1 |
Barygin, OI | 1 |
Isaeva, AV | 1 |
Portsel, MN | 1 |
Vlasov, TD | 1 |
Geng, X | 1 |
Sy, CA | 1 |
Kwiecien, TD | 1 |
Ji, X | 1 |
Peng, C | 1 |
Rastogi, R | 1 |
Cai, L | 1 |
Du, H | 1 |
Brogan, D | 1 |
Singh, S | 1 |
Rafols, JA | 1 |
Ding, Y | 1 |
Lu, Y | 1 |
Zhao, H | 2 |
Han, B | 1 |
Wang, T | 1 |
Cui, K | 1 |
Wang, S | 1 |
Arikan, F | 1 |
Martínez-Valverde, T | 1 |
Sánchez-Guerrero, Á | 1 |
Campos, M | 1 |
Esteves, M | 1 |
Gandara, D | 1 |
Torné, R | 1 |
Castro, L | 1 |
Dalmau, A | 1 |
Tibau, J | 1 |
Sahuquillo, J | 1 |
Lei, H | 2 |
Berthet, C | 3 |
Gruetter, R | 2 |
Wang, Q | 1 |
van Hoecke, M | 1 |
Tang, XN | 1 |
Lee, H | 1 |
Zheng, Z | 1 |
Swanson, RA | 1 |
Yenari, MA | 1 |
Woo, CW | 1 |
Lee, BS | 1 |
Kim, ST | 1 |
Kim, KS | 1 |
Wei, Y | 1 |
Shen, XN | 1 |
Mai, JY | 1 |
Shen, H | 1 |
Wang, RZ | 1 |
Wu, M | 1 |
Sumbria, RK | 1 |
Klein, J | 1 |
Bickel, U | 1 |
Ye, R | 1 |
Zhang, X | 1 |
Kong, X | 1 |
Han, J | 1 |
Yang, Q | 1 |
Zhang, Y | 1 |
Chen, Y | 1 |
Li, P | 1 |
Liu, J | 1 |
Shi, M | 1 |
Xiong, L | 1 |
Zhao, G | 1 |
Lopez-Gonzalez, MR | 1 |
Gallagher, L | 1 |
Alf, MF | 1 |
Mlynarik, V | 1 |
Hazekawa, M | 1 |
Sakai, Y | 1 |
Yoshida, M | 1 |
Haraguchi, T | 1 |
Uchida, T | 1 |
Castillo, X | 1 |
Magistretti, PJ | 1 |
Wei, J | 1 |
Cohen, DM | 1 |
Quast, MJ | 1 |
Liu, YJ | 1 |
Chen, CY | 1 |
Chung, HW | 1 |
Huang, IJ | 1 |
Lee, CS | 1 |
Chin, SC | 1 |
Liou, M | 1 |
Berger, C | 5 |
Dohmen, C | 3 |
Maurer, MH | 1 |
Graf, R | 3 |
Schwab, S | 5 |
Imamura, A | 1 |
Matsuo, N | 1 |
Ariki, M | 1 |
Horikoshi, H | 1 |
Hattori, T | 1 |
Sakowitz, OW | 1 |
Kiening, KL | 1 |
Hopwood, SE | 1 |
Parkin, MC | 1 |
Bezzina, EL | 1 |
Boutelle, MG | 1 |
Strong, AJ | 1 |
Frykholm, P | 3 |
Hillered, L | 3 |
Långström, B | 3 |
Persson, L | 3 |
Valtysson, J | 3 |
Enblad, P | 3 |
Walker, PM | 1 |
Ben Salem, D | 1 |
Giroud, M | 2 |
Brunotte, F | 2 |
Bosche, B | 1 |
Reithmeier, T | 1 |
Ernestus, RI | 1 |
Brinker, G | 2 |
Sobesky, J | 1 |
Heiss, WD | 2 |
Harada, K | 1 |
Honmou, O | 1 |
Liu, H | 1 |
Bando, M | 1 |
Houkin, K | 1 |
Kocsis, JD | 1 |
Kiening, K | 1 |
Fatar, M | 1 |
Stroick, M | 1 |
Griebe, M | 1 |
Alonso, A | 1 |
Kreisel, S | 1 |
Kern, R | 1 |
Hennerici, M | 1 |
Meairs, S | 1 |
Alessandri, B | 1 |
Basciani, R | 1 |
Langemann, H | 1 |
Lyrer, P | 1 |
Pluess, D | 1 |
Landolt, H | 1 |
Gratz, O | 1 |
Silander, HC | 1 |
Andersson, J | 1 |
Fasth, KJ | 1 |
Watanabe, Y | 2 |
Schneweis, S | 1 |
Grond, M | 1 |
Staub, F | 1 |
Neveling, M | 1 |
Badr, AE | 1 |
Yin, W | 1 |
Mychaskiw, G | 1 |
Zhang, JH | 1 |
Schäbitz, WR | 2 |
Schellinger, PD | 1 |
Aschoff, A | 2 |
Steiner, T | 2 |
Georgiadis, D | 1 |
Demougeot, C | 1 |
Walker, P | 1 |
Beley, A | 1 |
Marie, C | 1 |
Rouaud, O | 1 |
3 trials available for lactic acid and Infarction, Middle Cerebral Artery
Article | Year |
---|---|
Predictive value of neurochemical monitoring in large middle cerebral artery infarction.
Topics: Adult; Aged; Brain Edema; Critical Care; Electrodes, Implanted; Extracellular Space; Female; Frontal | 2001 |
Effects of hypothermia on excitatory amino acids and metabolism in stroke patients: a microdialysis study.
Topics: Adult; Aged; Brain; Female; Glutamic Acid; Glycerol; Humans; Hypothermia, Induced; Infarction, Middl | 2002 |
Spectroscopic data following stroke reveal tissue abnormality beyond the region of T2-weighted hyperintensity.
Topics: Aspartic Acid; Choline; Creatine; Female; Humans; Infarction, Middle Cerebral Artery; Lactic Acid; M | 2002 |
39 other studies available for lactic acid and Infarction, Middle Cerebral Artery
Article | Year |
---|---|
Lactate attenuates astrocytic inflammation by inhibiting ubiquitination and degradation of NDRG2 under oxygen-glucose deprivation conditions.
Topics: Animals; Astrocytes; Brain Ischemia; Glucose; Infarction, Middle Cerebral Artery; Inflammation; Lact | 2022 |
Astrocyte-neuron lactate shuttle plays a pivotal role in sensory-based neuroprotection in a rat model of permanent middle cerebral artery occlusion.
Topics: Animals; Astrocytes; Brain Ischemia; Infarction, Middle Cerebral Artery; Ischemic Attack, Transient; | 2023 |
Pre-stroke exercise does not reduce atrophy in healthy young adult mice.
Topics: Animals; Atrophy; Brain; Disease Models, Animal; Humans; Infarction, Middle Cerebral Artery; Lactic | 2023 |
Evaluating the potential of hyperpolarised [1-
Topics: Animals; Bicarbonates; Biosensing Techniques; Brain Ischemia; Carbon Isotopes; Computer Systems; Dis | 2020 |
Perfluorocarbon Enhanced Glasgow Oxygen Level Dependent (GOLD) Magnetic Resonance Metabolic Imaging Identifies the Penumbra Following Acute Ischemic Stroke.
Topics: Animals; Autoradiography; Brain; Brain Ischemia; Brain Mapping; Carbon Radioisotopes; Contrast Media | 2018 |
Involvement of monocarboxylate transporters in the cross-tolerance between epilepsy and cerebral infarction: A promising choice towards new treatments.
Topics: Animals; Antigens, Nuclear; Cerebral Infarction; Epilepsy; Glial Fibrillary Acidic Protein; Hippocam | 2019 |
The experimental therapy on brain ischemia by improvement of local angiogenesis with tissue engineering in the mouse.
Topics: Animals; Brain Ischemia; Cell Proliferation; Disease Models, Animal; Endothelial Cells; Gliosis; Hum | 2014 |
Inhibition of G protein-coupled receptor 81 (GPR81) protects against ischemic brain injury.
Topics: 3-Hydroxybutyric Acid; Animals; Brain Ischemia; Cell Death; Cell Hypoxia; Cell Line, Tumor; Cells, C | 2015 |
Neuroprotective activity of creatylglycine ethyl ester fumarate.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Behavior, Animal; Brain; Cell Survival; Creatine Kina | 2015 |
Reduced cerebral monocarboxylate transporters and lactate levels by ethanol and normobaric oxygen therapy in severe transient and permanent ischemic stroke.
Topics: Acidosis, Lactic; Animals; Brain; Brain Ischemia; Combined Modality Therapy; Disease Models, Animal; | 2015 |
Electro-acupuncture up-regulates astrocytic MCT1 expression to improve neurological deficit in middle cerebral artery occlusion rats.
Topics: Animals; Astrocytes; Biological Transport, Active; Brain; Electroacupuncture; Glial Fibrillary Acidi | 2015 |
Malignant infarction of the middle cerebral artery in a porcine model. A pilot study.
Topics: Animals; Brain; Disease Models, Animal; Female; Gene Expression; Glucose; Glycerol; Immunohistochemi | 2017 |
Evolution of the neurochemical profile after transient focal cerebral ischemia in the mouse brain.
Topics: Animals; Aspartic Acid; Cerebrovascular Circulation; Corpus Striatum; Glucose; Glutamic Acid; Glutam | 2009 |
Pyruvate protects against experimental stroke via an anti-inflammatory mechanism.
Topics: Animals; Body Weight; Cell Count; Disease Models, Animal; Ectodysplasins; Encephalitis; Infarction, | 2009 |
Correlation between lactate and neuronal cell damage in the rat brain after focal ischemia: An in vivo 1H magnetic resonance spectroscopic (1H-MRS) study.
Topics: Analysis of Variance; Animals; Apoptosis; Aspartic Acid; Biomarkers; Brain; Brain Ischemia; Creatini | 2010 |
[The effects of lycopene on reactive oxygen species and anoxic damage in ischemia reperfusion injury in rats].
Topics: Animals; Antioxidants; Brain Ischemia; Carotenoids; Hippocampus; Infarction, Middle Cerebral Artery; | 2010 |
Acute depression of energy metabolism after microdialysis probe implantation is distinct from ischemia-induced changes in mouse brain.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Ischemia; Energy Metabolism; Glucose; Glutamates; Glycero | 2011 |
Ginsenoside Rd attenuates mitochondrial dysfunction and sequential apoptosis after transient focal ischemia.
Topics: Aconitate Hydratase; Animals; Apoptosis; Brain; Calcium; Electron Transport; Ginsenosides; Glucose; | 2011 |
Novel MRI detection of the ischemic penumbra: direct assessment of metabolic integrity.
Topics: Animals; Brain Ischemia; Diffusion; Infarction, Middle Cerebral Artery; Lactic Acid; Magnetic Resona | 2012 |
High-resolution spatial mapping of changes in the neurochemical profile after focal ischemia in mice.
Topics: Animals; Aspartic Acid; Brain Ischemia; gamma-Aminobutyric Acid; Glutamic Acid; Glutathione; Infarct | 2012 |
Single injection of ONO-1301-loaded PLGA microspheres directly after ischaemia reduces ischaemic damage in rats subjected to middle cerebral artery occlusion.
Topics: Animals; Biocompatible Materials; Epoprostenol; Infarction, Middle Cerebral Artery; Injections, Subc | 2012 |
New evidence of neuroprotection by lactate after transient focal cerebral ischaemia: extended benefit after intracerebroventricular injection and efficacy of intravenous administration.
Topics: Administration, Intravenous; Animals; Infarction, Middle Cerebral Artery; Infusions, Intravenous; In | 2012 |
Effects of 2-deoxy-d-glucose on focal cerebral ischemia in hyperglycemic rats.
Topics: Animals; Antimetabolites; Aspartic Acid; Deoxyglucose; Hyperglycemia; Infarction, Middle Cerebral Ar | 2003 |
Neuronal damage after ischemic injury in the middle cerebral arterial territory: deep watershed versus territorial infarction at MR perfusion and spectroscopic imaging.
Topics: Aspartic Acid; Blood Volume; Brain; Brain Chemistry; Brain Ischemia; Cerebrovascular Circulation; Co | 2003 |
[Cerebral microdialysis in stroke].
Topics: Brain Edema; Critical Care; Diagnostic Imaging; Electrolytes; Energy Metabolism; Glutamic Acid; Glyc | 2004 |
MR imaging and 1H-MR spectroscopy in a case of cerebral infarction with transient cerebral arteriopathy.
Topics: Aspartic Acid; Brain; Carotid Artery, Internal, Dissection; Cerebral Infarction; Child; Choline; Cre | 2004 |
Neurochemical monitoring of glycerol therapy in patients with ischemic brain edema.
Topics: Adult; Aged; Brain; Brain Edema; Drug Monitoring; Edema; Female; Glutamic Acid; Glycerol; Humans; In | 2005 |
Transient changes in cortical glucose and lactate levels associated with peri-infarct depolarisations, studied with rapid-sampling microdialysis.
Topics: Animals; Blood Glucose; Brain Ischemia; Cats; Cortical Spreading Depression; Disease Models, Animal; | 2005 |
Relationship between cerebral blood flow and oxygen metabolism, and extracellular glucose and lactate concentrations during middle cerebral artery occlusion and reperfusion: a microdialysis and positron emission tomography study in nonhuman primates.
Topics: Animals; Cerebrovascular Circulation; Disease Models, Animal; Extracellular Space; Glucose; Infarcti | 2005 |
Is NAA reduction in normal contralateral cerebral tissue in stroke patients dependent on underlying risk factors?
Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain; Choline; Creatine; Dominance, Cerebral; Female | 2006 |
Identification and clinical impact of impaired cerebrovascular autoregulation in patients with malignant middle cerebral artery infarction.
Topics: Blood Pressure; Brain; Brain Edema; Cerebrovascular Circulation; Disease Progression; Energy Metabol | 2007 |
Magnetic resonance lactate and lipid signals in rat brain after middle cerebral artery occlusion model.
Topics: Animals; Azo Compounds; Brain; Cerebral Infarction; Disease Models, Animal; Female; Infarction, Midd | 2007 |
Neurochemical monitoring of therapeutic effects in large human MCA infarction.
Topics: Craniotomy; Critical Care; Female; Glutamic Acid; Glycerol; Humans; Hypothermia, Induced; Infarction | 2008 |
Effect of combined ultrasound and microbubbles treatment in an experimental model of cerebral ischemia.
Topics: Animals; Biomarkers; Brain Ischemia; Glutamic Acid; Glycerol; Infarction, Middle Cerebral Artery; La | 2008 |
Chronic effects of an aminosteroid on microdialytically measured parameters after experimental middle cerebral artery occlusion in the rat.
Topics: Animals; Ascorbic Acid; Brain Ischemia; Drug Evaluation, Preclinical; Free Radicals; Glucose; Infarc | 2000 |
Middle cerebral artery occlusion and reperfusion in primates monitored by microdialysis and sequential positron emission tomography.
Topics: Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Glutamic Acid; Hypoxanthine; Infarction | 2001 |
Increase of interstitial glycerol reflects the degree of ischaemic brain damage: a PET and microdialysis study in a middle cerebral artery occlusion-reperfusion primate model.
Topics: Animals; Brain Damage, Chronic; Extracellular Space; Glutamic Acid; Glycerol; Infarction, Middle Cer | 2001 |
Effect of hyperbaric oxygen on striatal metabolites: a microdialysis study in awake freely moving rats after MCA occlusion.
Topics: Animals; Brain Ischemia; Corpus Striatum; Energy Metabolism; Extracellular Space; Glucose; Glutamic | 2001 |
Neurometabolic changes during treatment with moderate hypothermia in a patient suffering from severe middle cerebral artery infarction.
Topics: Adult; Brain Ischemia; Extracellular Space; Glutamic Acid; Glycerol; Humans; Hypothermia, Induced; I | 2001 |