lactic acid has been researched along with Idiopathic Parkinson Disease in 27 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Parkinson disease is associated with decreased activity of the mitochondrial electron transport chain." | 1.42 | MicroRNA-7 Promotes Glycolysis to Protect against 1-Methyl-4-phenylpyridinium-induced Cell Death. ( Chaudhuri, AD; Choi, DC; Junn, E; Kabaria, S; Mouradian, MM, 2015) |
| " In this study, we assessed the effects of a subpopulation of human MSCs, the marrow-isolated adult multilineage inducible (MIAMI) cells, combined with pharmacologically active microcarriers (PAMs) in a rat model of Parkinson's disease (PD)." | 1.37 | The therapeutic potential of human multipotent mesenchymal stromal cells combined with pharmacologically active microcarriers transplanted in hemi-parkinsonian rats. ( Delcroix, GJ; Garbayo, E; Montero-Menei, CN; Schiller, PC; Sindji, L; Thomas, O; Vanpouille-Box, C, 2011) |
| "A total of 66 participants with Parkinson's disease and 32 age-matched, healthy controls participated." | 1.32 | Effects of respiratory muscle weakness on daily living function, quality of life, activity levels, and exercise capacity in mild to moderate Parkinson's disease. ( Castle, PC; Haas, BM; Trew, M, 2004) |
| "Patient 2 presented with multiple symmetric lipomatosis." | 1.31 | Mitochondrial DNA rearrangements in young onset parkinsonism: two case reports. ( Bonuccelli, U; Ceravolo, R; Iudice, A; Lombardi, V; Mancuso, M; Siciliano, G, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (11.11) | 18.2507 |
| 2000's | 8 (29.63) | 29.6817 |
| 2010's | 12 (44.44) | 24.3611 |
| 2020's | 4 (14.81) | 2.80 |
| Authors | Studies |
|---|---|
| Fedotova, EI | 1 |
| Dolgacheva, LP | 1 |
| Abramov, AY | 1 |
| Berezhnov, AV | 1 |
| Choi, J | 1 |
| Tak, S | 1 |
| Jung, HM | 1 |
| Cha, S | 1 |
| Hwang, E | 1 |
| Lee, D | 1 |
| Lee, JH | 1 |
| Ryu, KS | 1 |
| Park, C | 1 |
| Coukos, JS | 1 |
| Lee, CW | 1 |
| Pillai, KS | 1 |
| Shah, H | 1 |
| Moellering, RE | 1 |
| Miyaue, N | 1 |
| Yabe, H | 1 |
| Nagai, M | 1 |
| Moradian, H | 1 |
| Keshvari, H | 1 |
| Fasehee, H | 1 |
| Dinarvand, R | 1 |
| Faghihi, S | 1 |
| Barcia, E | 2 |
| Boeva, L | 1 |
| García-García, L | 1 |
| Slowing, K | 2 |
| Fernández-Carballido, A | 2 |
| Casanova, Y | 1 |
| Negro, S | 2 |
| Matsuda, N | 1 |
| Kimura, M | 1 |
| Queliconi, BB | 1 |
| Kojima, W | 1 |
| Mishima, M | 1 |
| Takagi, K | 1 |
| Koyano, F | 1 |
| Yamano, K | 1 |
| Mizushima, T | 1 |
| Ito, Y | 1 |
| Tanaka, K | 1 |
| Xie, CL | 1 |
| Wang, WW | 1 |
| Zhang, SF | 1 |
| Yuan, ML | 1 |
| Che, JY | 1 |
| Gan, J | 1 |
| Song, L | 1 |
| Yuan, WE | 1 |
| Liu, ZG | 1 |
| Chaudhuri, AD | 1 |
| Kabaria, S | 1 |
| Choi, DC | 1 |
| Mouradian, MM | 1 |
| Junn, E | 1 |
| Pahuja, R | 1 |
| Seth, K | 1 |
| Shukla, A | 1 |
| Shukla, RK | 1 |
| Bhatnagar, P | 1 |
| Chauhan, LK | 1 |
| Saxena, PN | 1 |
| Arun, J | 1 |
| Chaudhari, BP | 1 |
| Patel, DK | 1 |
| Singh, SP | 1 |
| Shukla, R | 1 |
| Khanna, VK | 1 |
| Kumar, P | 1 |
| Chaturvedi, RK | 1 |
| Gupta, KC | 1 |
| Tuppy, M | 1 |
| Barna, BF | 1 |
| Alves-Dos-Santos, L | 1 |
| Britto, LR | 1 |
| Chiavegatto, S | 1 |
| Moreira, TS | 1 |
| Takakura, AC | 1 |
| Bourdenx, M | 1 |
| Daniel, J | 1 |
| Genin, E | 1 |
| Soria, FN | 1 |
| Blanchard-Desce, M | 1 |
| Bezard, E | 1 |
| Dehay, B | 1 |
| Yelkenli, İH | 1 |
| Ulupinar, E | 1 |
| Korkmaz, OT | 1 |
| Şener, E | 1 |
| Kuş, G | 1 |
| Filiz, Z | 1 |
| Tunçel, N | 1 |
| Garbayo, E | 2 |
| Montero-Menei, CN | 2 |
| Ansorena, E | 1 |
| Lanciego, JL | 1 |
| Aymerich, MS | 1 |
| Blanco-Prieto, MJ | 1 |
| Delcroix, GJ | 1 |
| Sindji, L | 1 |
| Thomas, O | 1 |
| Vanpouille-Box, C | 1 |
| Schiller, PC | 1 |
| Martins-Branco, D | 1 |
| Esteves, AR | 1 |
| Santos, D | 1 |
| Arduino, DM | 1 |
| Swerdlow, RH | 1 |
| Oliveira, CR | 1 |
| Januario, C | 1 |
| Cardoso, SM | 1 |
| Fernández, M | 1 |
| Garcia, L | 1 |
| Abdo, WF | 1 |
| De Jong, D | 1 |
| Hendriks, JC | 1 |
| Horstink, MW | 2 |
| Kremer, BP | 1 |
| Bloem, BR | 1 |
| Verbeek, MM | 1 |
| Haas, BM | 1 |
| Trew, M | 1 |
| Castle, PC | 1 |
| Dahm, R | 1 |
| Zijlmans, JC | 1 |
| de Koster, A | 1 |
| van 't Hof, MA | 1 |
| Thijssen, HO | 1 |
| Heerschap, A | 1 |
| Moy, LY | 1 |
| Zeevalk, GD | 1 |
| Sonsalla, PK | 1 |
| Gårseth, M | 1 |
| Sonnewald, U | 1 |
| White, LR | 1 |
| Rød, M | 1 |
| Zwart, JA | 1 |
| Nygaard, O | 1 |
| Aasly, J | 1 |
| Matsubara, K | 1 |
| Senda, T | 1 |
| Uezono, T | 1 |
| Awaya, T | 1 |
| Ogawa, S | 1 |
| Chiba, K | 1 |
| Shimizu, K | 1 |
| Hayase, N | 1 |
| Kimura, K | 1 |
| Siciliano, G | 1 |
| Mancuso, M | 1 |
| Ceravolo, R | 1 |
| Lombardi, V | 1 |
| Iudice, A | 1 |
| Bonuccelli, U | 1 |
| Nakagawa-Hattori, Y | 1 |
| Yoshino, H | 1 |
| Kondo, T | 1 |
| Mizuno, Y | 1 |
| Horai, S | 1 |
| Bravi, D | 1 |
| Anderson, JJ | 1 |
| Dagani, F | 1 |
| Davis, TL | 1 |
| Ferrari, R | 1 |
| Gillespie, M | 1 |
| Chase, TN | 1 |
27 other studies available for lactic acid and Idiopathic Parkinson Disease
| Article | Year |
|---|---|
Lactate and Pyruvate Activate Autophagy and Mitophagy that Protect Cells in Toxic Model of Parkinson's Disease.
Topics: Animals; Astrocytes; Autophagy; Cell Line, Tumor; Cell Survival; Humans; Lactic Acid; Membrane Poten | 2022 |
Kinetic evidence in favor of glyoxalase III and against deglycase activity of DJ-1.
Topics: Aldehyde Oxidoreductases; Humans; Lactic Acid; Parkinson Disease; Protein Deglycase DJ-1; Pyruvaldeh | 2023 |
PARK7 Catalyzes Stereospecific Detoxification of Methylglyoxal Consistent with Glyoxalase and Not Deglycase Function.
Topics: Humans; Lactic Acid; Magnesium Oxide; Parkinson Disease; Protein Deglycase DJ-1; Pyruvaldehyde | 2023 |
Serum growth differentiation factor 15, but not lactate, is elevated in patients with Parkinson's disease.
Topics: Aged; Aged, 80 and over; Asian People; Biomarkers; Case-Control Studies; Female; Growth Differentiat | 2020 |
Combining NT3-overexpressing MSCs and PLGA microcarriers for brain tissue engineering: A potential tool for treatment of Parkinson's disease.
Topics: Brain; Cell Differentiation; Humans; Lactic Acid; Mesenchymal Stem Cells; Parkinson Disease; Polygly | 2017 |
Nanotechnology-based drug delivery of ropinirole for Parkinson's disease.
Topics: Animals; Drug Carriers; Drug Delivery Systems; Indoles; Lactic Acid; Male; Nanoparticles; Parkinson | 2017 |
Parkinson's disease-related DJ-1 functions in thiol quality control against aldehyde attack in vitro.
Topics: Acetylcysteine; Aldehydes; Amino Acid Sequence; beta-Alanine; Coenzyme A; Glutathione; HeLa Cells; H | 2017 |
Levodopa/benserazide microsphere (LBM) prevents L-dopa induced dyskinesia by inactivation of the DR1/PKA/P-tau pathway in 6-OHDA-lesioned Parkinson's rats.
Topics: Adrenergic Agents; Animals; Benserazide; Blotting, Western; Corpus Striatum; Cyclic AMP-Dependent Pr | 2014 |
MicroRNA-7 Promotes Glycolysis to Protect against 1-Methyl-4-phenylpyridinium-induced Cell Death.
Topics: 1-Methyl-4-phenylpyridinium; Adenosine Triphosphate; Animals; Cell Death; Cell Differentiation; Cell | 2015 |
Trans-blood brain barrier delivery of dopamine-loaded nanoparticles reverses functional deficits in parkinsonian rats.
Topics: Animals; Blood-Brain Barrier; Cell Line, Tumor; Dopamine; Dopaminergic Neurons; Drug Carriers; Drug | 2015 |
Respiratory deficits in a rat model of Parkinson's disease.
Topics: Adrenergic Agents; Animals; Cell Count; Corpus Striatum; Disease Models, Animal; Hydrogen-Ion Concen | 2015 |
Nanoparticles restore lysosomal acidification defects: Implications for Parkinson and other lysosomal-related diseases.
Topics: 1-Methyl-4-phenylpyridinium; Acids; Alkalies; Animals; Cell Death; Dopaminergic Neurons; Humans; Hyd | 2016 |
Modulation of Corpus Striatal Neurochemistry by Astrocytes and Vasoactive Intestinal Peptide (VIP) in Parkinsonian Rats.
Topics: Animals; Astrocytes; Corpus Striatum; gamma-Aminobutyric Acid; Glial Fibrillary Acidic Protein; Glio | 2016 |
Effective GDNF brain delivery using microspheres--a promising strategy for Parkinson's disease.
Topics: Animals; Brain; Cell Differentiation; Corpus Striatum; Disease Models, Animal; Drug Carriers; Drug D | 2009 |
The therapeutic potential of human multipotent mesenchymal stromal cells combined with pharmacologically active microcarriers transplanted in hemi-parkinsonian rats.
Topics: Animals; Behavior, Animal; Cell Differentiation; Female; Fluorescent Antibody Technique; Humans; Lac | 2011 |
Ubiquitin proteasome system in Parkinson's disease: a keeper or a witness?
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Analysis of Variance; Case-Control Studies; Cell Line, | 2012 |
Controlled release of rasagiline mesylate promotes neuroprotection in a rotenone-induced advanced model of Parkinson's disease.
Topics: Animals; Apoptosis; Behavior, Animal; Cell Line, Tumor; Delayed-Action Preparations; Disease Models, | 2012 |
Cerebrospinal fluid analysis differentiates multiple system atrophy from Parkinson's disease.
Topics: Adult; Aged; Benzamides; Brain; Diagnosis, Differential; Electromyography; Enzyme-Linked Immunosorbe | 2004 |
Effects of respiratory muscle weakness on daily living function, quality of life, activity levels, and exercise capacity in mild to moderate Parkinson's disease.
Topics: Activities of Daily Living; Aged; Exercise; Exercise Test; Exercise Tolerance; Female; Health Status | 2004 |
Dying to see.
Topics: Acquired Immunodeficiency Syndrome; Aged; Aging; Alzheimer Disease; Animals; Apoptosis; Cataract; Ey | 2004 |
Proton magnetic resonance spectroscopy in suspected vascular ischemic parkinsonism.
Topics: Aged; Aspartic Acid; Brain; Brain Ischemia; Brain Mapping; Energy Metabolism; Female; Humans; Intrac | 1994 |
Role for dopamine in malonate-induced damage in vivo in striatum and in vitro in mesencephalic cultures.
Topics: 2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-; 3,4-Dihydrox | 2000 |
Proton magnetic resonance spectroscopy of cerebrospinal fluid in neurodegenerative disease: indication of glial energy impairment in Huntington chorea, but not Parkinson disease.
Topics: Adult; Aged; Citric Acid; Energy Metabolism; Female; Humans; Huntington Disease; Lactic Acid; Magnet | 2000 |
L-Deprenyl prevents the cell hypoxia induced by dopaminergic neurotoxins, MPP(+) and beta-carbolinium: a microdialysis study in rats.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Carbolines; Cell Hypoxia; Dopamine; Dose-Response Relationship | 2001 |
Mitochondrial DNA rearrangements in young onset parkinsonism: two case reports.
Topics: Adult; Creatine Kinase; DNA, Mitochondrial; Gene Rearrangement; Humans; Lactic Acid; Lipomatosis, Mu | 2001 |
Is Parkinson's disease a mitochondrial disorder?
Topics: Aerobiosis; Aged; Blotting, Southern; DNA, Mitochondrial; Exercise Test; Humans; Lactates; Lactic Ac | 1992 |
Effect of aging and dopaminomimetic therapy on mitochondrial respiratory function in Parkinson's disease.
Topics: Age Factors; Blood Glucose; Blood Platelets; Carbidopa; Drug Therapy, Combination; Energy Metabolism | 1992 |