Page last updated: 2024-10-17

lactic acid and Hypothyroidism

lactic acid has been researched along with Hypothyroidism in 15 studies

Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.

Hypothyroidism: A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL METABOLIC RATE. In its most severe form, there is accumulation of MUCOPOLYSACCHARIDES in the SKIN and EDEMA, known as MYXEDEMA. It may be primary or secondary due to other pituitary disease, or hypothalamic dysfunction.

Research Excerpts

ExcerptRelevanceReference
"Metformin-associated lactic acidosis (MALA) carries a high mortality rate."7.96Metformin-associated lactic acidosis: reinforcing learning points. ( Creagh, F; Goonoo, MS; Morris, R; Raithatha, A, 2020)
" The aim of this study was to investigate the effects of hypothyroidism on leucine, mannose, glucose and lactate metabolism in rat cerebellar slices."7.79Propylthiouracil-induced hypothyroidism during lactation alters leucine and mannose metabolism in rat cerebellar slices. ( da Silveira, CK; de Assis, AM; Farina, M; Longoni, A; Müller, AP; Perry, ML; Souza, DO, 2013)
"Metformin-associated lactic acidosis (MALA) carries a high mortality rate."3.96Metformin-associated lactic acidosis: reinforcing learning points. ( Creagh, F; Goonoo, MS; Morris, R; Raithatha, A, 2020)
" The aim of this study was to investigate the effects of hypothyroidism on leucine, mannose, glucose and lactate metabolism in rat cerebellar slices."3.79Propylthiouracil-induced hypothyroidism during lactation alters leucine and mannose metabolism in rat cerebellar slices. ( da Silveira, CK; de Assis, AM; Farina, M; Longoni, A; Müller, AP; Perry, ML; Souza, DO, 2013)
"Further, neonatal hypothyroidism affected germ cell proliferation with decreased expression of proliferating cell nuclear antigen (PCNA) and Cx43."1.46Neonatal hypothyroidism affects testicular glucose homeostasis through increased oxidative stress in prepubertal mice: effects on GLUT3, GLUT8 and Cx43. ( Sarkar, D; Singh, SK, 2017)
"Treatment with triiodothyronine for 5 or 10 days decreased the sensitivity of glycogen synthesis but increased the sensitivity of lactate formation to insulin."1.30The effects of insulin on transport and metabolism of glucose in skeletal muscle from hyperthyroid and hypothyroid rats. ( Bevan, S; Challiss, RA; Dimitriadis, G; Krause, U; Leighton, B; Newsholme, EA; Parry-Billings, M; Piva, T; Tegos, K; Wegener, G, 1997)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19905 (33.33)18.7374
1990's2 (13.33)18.2507
2000's3 (20.00)29.6817
2010's3 (20.00)24.3611
2020's2 (13.33)2.80

Authors

AuthorsStudies
Hiraki, N1
Tanaka, TD1
Yoshimura, M1
Goonoo, MS1
Morris, R1
Raithatha, A1
Creagh, F1
Sarkar, D1
Singh, SK1
Müller, AP1
Longoni, A1
Farina, M1
da Silveira, CK1
Souza, DO1
Perry, ML1
de Assis, AM1
Lankhaar, JA1
de Vries, WR1
Jansen, JA1
Zelissen, PM1
Backx, FJ1
Eynan, M1
Knubuvetz, T1
Meiri, U1
Navon, G1
Gerstenblith, G1
Bromberg, Z1
Hasin, Y1
Horowitz, M1
Caraccio, N1
Natali, A1
Sironi, A1
Baldi, S1
Frascerra, S1
Dardano, A1
Monzani, F1
Ferrannini, E1
Storm, H1
Van Hardeveld, C1
Kassenaar, AA1
Almeida, A1
González-Buitrago, JM1
Bolaños, JP1
Medina, JM1
Dimitriadis, G1
Parry-Billings, M1
Bevan, S1
Leighton, B1
Krause, U1
Piva, T1
Tegos, K1
Challiss, RA1
Wegener, G1
Newsholme, EA1
Kneer, N1
Lardy, H1
Müller, MJ1
Seitz, HJ1
Dudley, GA1
Tullson, PC1
Terjung, RL1
Everts, ME1
Clausen, T1
Heimberg, M1
Olubadewo, JO1
Wilcox, HG1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Study of Metformin Overdose in Adult Patients Treated at the University Hospital of Nancy: Single-center Descriptive Retrospective Observational Study[NCT04762966]50 participants (Anticipated)Observational2021-03-01Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for lactic acid and Hypothyroidism

ArticleYear
Impact of overt and subclinical hypothyroidism on exercise tolerance: a systematic review.
    Research quarterly for exercise and sport, 2014, Volume: 85, Issue:3

    Topics: Blood Flow Velocity; Blood Pressure; Echocardiography; Electrocardiography; Exercise Tolerance; Hear

2014
Plasma lipoproteins and regulation of hepatic metabolism of fatty acids in altered thyroid states.
    Endocrine reviews, 1985,Fall, Volume: 6, Issue:4

    Topics: Alanine; Animals; Apolipoproteins; Cholesterol, HDL; Cholesterol, LDL; Fatty Acids; Fatty Acids, Non

1985

Trials

1 trial available for lactic acid and Hypothyroidism

ArticleYear
Muscle metabolism and exercise tolerance in subclinical hypothyroidism: a controlled trial of levothyroxine.
    The Journal of clinical endocrinology and metabolism, 2005, Volume: 90, Issue:7

    Topics: Adult; Double-Blind Method; Exercise; Fatty Acids, Nonesterified; Female; Follow-Up Studies; Hormone

2005

Other Studies

12 other studies available for lactic acid and Hypothyroidism

ArticleYear
A Man With Left Ventricular Hypertrophy.
    JAMA cardiology, 2022, 02-01, Volume: 7, Issue:2

    Topics: Adult; Atrophy; Cardiomyopathies; Cerebellar Diseases; Cognitive Dysfunction; Echocardiography; Gluc

2022
Metformin-associated lactic acidosis: reinforcing learning points.
    BMJ case reports, 2020, Sep-02, Volume: 13, Issue:9

    Topics: Acidosis, Lactic; Acute Kidney Injury; Bicarbonates; Continuous Renal Replacement Therapy; Diabetes

2020
Neonatal hypothyroidism affects testicular glucose homeostasis through increased oxidative stress in prepubertal mice: effects on GLUT3, GLUT8 and Cx43.
    Andrology, 2017, Volume: 5, Issue:4

    Topics: Age Factors; Animals; Animals, Newborn; Antioxidants; Apoptosis; Cell Proliferation; Connexin 43; Di

2017
Propylthiouracil-induced hypothyroidism during lactation alters leucine and mannose metabolism in rat cerebellar slices.
    Experimental biology and medicine (Maywood, N.J.), 2013, Volume: 238, Issue:1

    Topics: Animals; Carbon Dioxide; Cerebellum; Disease Models, Animal; Female; Glucose; Hypothyroidism; Lactat

2013
Heat acclimation-induced elevated glycogen, glycolysis, and low thyroxine improve heart ischemic tolerance.
    Journal of applied physiology (Bethesda, Md. : 1985), 2002, Volume: 93, Issue:6

    Topics: Acclimatization; Animals; Carbon Isotopes; Glucose; Glycogen; Glycolysis; Hot Temperature; Hypothyro

2002
The influence of hypothyroidism on the adrenergic stimulation of glycogenolysis in perfused rat liver.
    Biochimica et biophysica acta, 1984, Apr-24, Volume: 798, Issue:3

    Topics: Animals; Calcium; Glucose-6-Phosphate; Glucosephosphates; Hypothyroidism; Lactates; Lactic Acid; Liv

1984
Fuel utilization by early newborn brain is preserved under congenital hypothyroidism in the rat.
    Pediatric research, 1996, Volume: 40, Issue:3

    Topics: 3-Hydroxybutyric Acid; Animals; Animals, Newborn; Antithyroid Agents; Brain; Congenital Hypothyroidi

1996
The effects of insulin on transport and metabolism of glucose in skeletal muscle from hyperthyroid and hypothyroid rats.
    European journal of clinical investigation, 1997, Volume: 27, Issue:6

    Topics: Animals; Biological Transport, Active; Cortisone; Dinoprostone; Drug Interactions; Glucose; Glycogen

1997
Thyroid hormone and dehydroepiandrosterone permit gluconeogenic hormone responses in hepatocytes.
    Archives of biochemistry and biophysics, 2000, Mar-01, Volume: 375, Issue:1

    Topics: Aminooxyacetic Acid; Animals; Calcium; Cyclic AMP; Dehydroepiandrosterone; Glucagon; Gluconeogenesis

2000
Interrelation between thyroid state and the effect of glucagon on gluconeogenesis in perfused rat livers.
    Biochemical pharmacology, 1987, May-15, Volume: 36, Issue:10

    Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Alanine; Aminoisobutyric Acids; An

1987
Influence of mitochondrial content on the sensitivity of respiratory control.
    The Journal of biological chemistry, 1987, Jul-05, Volume: 262, Issue:19

    Topics: Adenylate Kinase; AMP Deaminase; Animals; Creatine Kinase; Glycolysis; Hypothyroidism; Lactates; Lac

1987
Effects of thyroid hormones on calcium contents and 45Ca exchange in rat skeletal muscle.
    The American journal of physiology, 1986, Volume: 251, Issue:3 Pt 1

    Topics: Animals; Calcium; Calcium Radioisotopes; Dantrolene; Female; Gallopamil; Hyperthyroidism; Hypothyroi

1986