lactic acid and Hyperglycemia, Postprandial studies

Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.

Research Excerpts

Excerpt	Relevance	Reference
" Therefore, we carried out a randomized, double-blind study to compare the effects of losartan (50 mg QD) and metoprolol (95 mg QD) on insulin sensitivity, insulin secretion, glucose tolerance, and lipids and lipoproteins in 20 hyperinsulinemic subjects with essential hypertension."	9.08	Effects of losartan on insulin sensitivity in hypertensive subjects. ( Karjalainen, L; Laakso, M; Lempiäinen-Kuosa, P, 1996)
"The present study was undertaken to investigate the effects of the alpha2 adrenergic agonist, clonidine, on the near complete cerebral ischemia (NCFI) evoked release of glutamate and aspartate from normo- and hyperglycemic rodent brain tissue using microdialysis tissue techniques."	7.73	The effect of clonidine on cell survival, glutamate, and aspartate release in normo- and hyperglycemic rats after near complete forebrain ischemia. ( Jellish, WS; Kindel, G; Murdoch, J; White, FA; Zhang, X, 2005)
" The aim of this study was to determine whether hyperglycemia, glucagon, or epinephrine can affect renal glucose production."	7.72	Effects of hyperglycemia, glucagon, and epinephrine on renal glucose release in the conscious dog. ( Cherrington, AD; Chu, CA; Donahue, EP; Farmer, B; Flakoll, P; Gustavson, SM; Neal, D; Nishizawa, M; Yang, Y, 2004)
"The physiological significance of central cholinergic neurons was investigated by verifying the effect of previous intracerebroventricular administration of atropine on the hyperglycemia induced by 2-deoxyglucose (2-DG) or by immobilization stress in unrestrained, nonanesthetized rats."	7.71	Centrally injected atropine reduces hyperglycemia caused by 2-DG or immobilization stress in awake rats. ( Brito, MN; Brito, NA; Kettelhut, IC; Migliorini, RH; Timo-Iaria, C, 2001)
"Lactic acidosis (LAc) is a common form of metabolic acidosis early after heart transplantation (HTX)."	7.71	Lactic acidosis following heart transplantation: a common phenomenon? ( Carrel, T; Hullin, R; Mohacsi, P; Pedrazzinia, G; Tanner, H; Tschanz, HU, 2002)
"This case report of metaproterenol toxicity was associated with hypokalemia, hyperglycemia and hyperlactatemia."	7.71	Metabolic effects of metaproterenol overdose: hypokalemia, hyperglycemia and hyperlactatemia. ( Barnewolt, BA; Bey, TA; Walter, FG, 2001)
" Glucose and lactic acid in vitreous humor and blood levels of acetone were found to be valuable indicators of antemortem hyperglycemia in diabetics."	7.69	The use of vitreous humor levels of glucose, lactic acid and blood levels of acetone to establish antemortem hyperglycemia in diabetics. ( Jobin, F; Péclet, C; Picotte, P, 1994)
"In vivo, treatment of an ovarian cancer mouse model with metformin resulted in greater tumor weight reduction in normoglycemic vs."	5.42	Hyperglycemia-induced metabolic compensation inhibits metformin sensitivity in ovarian cancer. ( Eckert, MA; Johnson, A; Lengyel, E; Litchfield, LM; Mills, KA; Mukherjee, A; Pan, S; Romero, IL; Shridhar, V, 2015)
"In vivo models of cerebral ischemia pose a conceptual challenge when compared to in vitro models."	5.31	Preischemic hyperglycemia-aggravated damage: evidence that lactate utilization is beneficial and glucose-induced corticosterone release is detrimental. ( Miller, JJ; Payne, RS; Schurr, A; Tseng, MT, 2001)
"Hyperglycemia was found consistently within 12 hours after injury (224 +/- 98 mg/dl, P less than 0."	5.27	Hyperglycemia, cerebrospinal fluid lactic acidosis, and cerebral blood flow in severely head-injured patients. ( De Salles, AA; Muizelaar, JP; Young, HF, 1987)
"Glucose, Traub formula, fructosamine, and beta-hydroxy-butyrate can be used to detect postmortem hyperglycemia with some limitations; 1,5 Anhydro-d-glucitol can only be used to suggest the absence of a hyperglycemic status before death."	5.12	Markers of hyperglycemia in the vitreous humor. A systematic review and meta-analysis. ( Hostiuc, M; Hostiuc, S; Negoi, I, 2021)
" Therefore, we carried out a randomized, double-blind study to compare the effects of losartan (50 mg QD) and metoprolol (95 mg QD) on insulin sensitivity, insulin secretion, glucose tolerance, and lipids and lipoproteins in 20 hyperinsulinemic subjects with essential hypertension."	5.08	Effects of losartan on insulin sensitivity in hypertensive subjects. ( Karjalainen, L; Laakso, M; Lempiäinen-Kuosa, P, 1996)
" This review discusses 3 issues that concern homeostasis in the acute care of trauma patients directly related to the stress response: hyperglycemia, lactic acidosis, and hypothermia."	4.89	Trauma and aggressive homeostasis management. ( Baranov, D; Neligan, PJ, 2013)
"Three important issues concerning homeostasis in the acute care of trauma patients that are related directly to the stress response are hyperglycemia, lactic acidosis, and hypothermia."	4.84	Trauma and aggressive homeostasis management. ( Baranov, D; Neligan, P, 2007)
" Analysis of the sticking blood revealed that both slaughter procedures caused a substantial increase in the levels of catecholamines, hypercalcemia, hyperglycemia, lactic acidemia and an increase in enzyme activities."	3.80	Influence of gas stunning and halal slaughter (no stunning) on rabbits welfare indicators and meat quality. ( Abu Bakar, F; Goh, YM; Nakyinsige, K; Sabow, AB; Sazili, AQ; Zulkifli, I, 2014)
" Pre-treatment of rats with mifepristone (glucocorticoid receptor antagonist) prevented induction of liver tyrosine aminotransferase activity (TAT), but was ineffective in attenuating hyperglycemia induced by monocrotophos."	3.78	Insights into the mechanisms mediating hyperglycemic and stressogenic outcomes in rats treated with monocrotophos, an organophosphorus insecticide. ( Joshi, AK; Nagaraju, R; Rajini, PS, 2012)
"In 175 consecutive patients without previously known diabetes and with ST elevation myocardial infarction treated with primary angioplasty, we evaluated the relation between acute and chronic glucose dysmetabolism and early and late mortality and the relation between hyperglycemia and extension of myocardial damage [creatine phosphokinase-MB (CPK-MB), troponin I levels, ejection fraction], inflammation (leukocyte count, erythrocyte sedimentation rate, C-reactive protein) and prognostic biohumoral markers [N-terminal brain natriuretic peptide (NT-proBNP) and lactic acid]."	3.76	Postprocedural hyperglycemia in ST elevation myocardial infarction submitted to percutaneous coronary intervention: a prognostic indicator and a marker of metabolic derangement. ( Chiostri, M; Gensini, GF; Lazzeri, C; Sori, A; Valente, S, 2010)
"The present study was undertaken to investigate the effects of the alpha2 adrenergic agonist, clonidine, on the near complete cerebral ischemia (NCFI) evoked release of glutamate and aspartate from normo- and hyperglycemic rodent brain tissue using microdialysis tissue techniques."	3.73	The effect of clonidine on cell survival, glutamate, and aspartate release in normo- and hyperglycemic rats after near complete forebrain ischemia. ( Jellish, WS; Kindel, G; Murdoch, J; White, FA; Zhang, X, 2005)
" The aim of this study was to determine whether hyperglycemia, glucagon, or epinephrine can affect renal glucose production."	3.72	Effects of hyperglycemia, glucagon, and epinephrine on renal glucose release in the conscious dog. ( Cherrington, AD; Chu, CA; Donahue, EP; Farmer, B; Flakoll, P; Gustavson, SM; Neal, D; Nishizawa, M; Yang, Y, 2004)
"The primary aim of these experiments was to assess in vitro effects of hyperglycemia (30 mmol/l glucose) and hypoxia (Po(2) = 36 torr) of 2-h duration, separately and in combination, on cytosolic and mitochondrial free NADH (NADHc and NADHm, respectively) in retinas from normal rats."	3.72	Interactions between hyperglycemia and hypoxia: implications for diabetic retinopathy. ( Ido, Y; Kilo, C; Nyengaard, JR; Williamson, JR, 2004)
"This case report of metaproterenol toxicity was associated with hypokalemia, hyperglycemia and hyperlactatemia."	3.71	Metabolic effects of metaproterenol overdose: hypokalemia, hyperglycemia and hyperlactatemia. ( Barnewolt, BA; Bey, TA; Walter, FG, 2001)
" Each study consisted of an equilibration (-140 to -40 min), a control (-40 to 0 min), and a test period (0 to 180 min), during which BAY R3401 (10 mg/kg), a glycogen phosphorylase inhibitor, was administered orally, either alone to create mild hypoglycemia or with peripheral glucose infusion to maintain euglycemia or create mild hyperglycemia."	3.71	Alpha- and beta-cell responses to small changes in plasma glucose in the conscious dog. ( Cherrington, AD; Emshwiller, MG; Flattem, N; Igawa, K; Neal, DW; Shiota, M, 2001)
"Lactic acidosis (LAc) is a common form of metabolic acidosis early after heart transplantation (HTX)."	3.71	Lactic acidosis following heart transplantation: a common phenomenon? ( Carrel, T; Hullin, R; Mohacsi, P; Pedrazzinia, G; Tanner, H; Tschanz, HU, 2002)
"The physiological significance of central cholinergic neurons was investigated by verifying the effect of previous intracerebroventricular administration of atropine on the hyperglycemia induced by 2-deoxyglucose (2-DG) or by immobilization stress in unrestrained, nonanesthetized rats."	3.71	Centrally injected atropine reduces hyperglycemia caused by 2-DG or immobilization stress in awake rats. ( Brito, MN; Brito, NA; Kettelhut, IC; Migliorini, RH; Timo-Iaria, C, 2001)
"The authors performed this study to evaluate the selective acidification of a human melanoma xenograft in mice with severe combined immunodeficiency with the induction of hyperglycemia (mean blood glucose level +/- standard error of the mean, 26 mmol/L +/- 1) and the intraperitoneal administration of metaiodobenzylguanidine (MIBG, 30 mg/kg), alpha-cyano-4-hydroxycinnamate (CNCn, 300 mg/kg), lonidamine (100 mg/kg), cariporide (HOE642, 160 mg/kg), or 4."	3.71	Enhancement of hyperglycemia-induced acidification of human melanoma xenografts with inhibitors of respiration and ion transport. ( Bansal, N; Glickson, JD; Leeper, DB; Pickup, S; Zhou, R, 2001)
" Hyperglycemia-induced increases of plasma C-peptide concentrations were comparable to those in controls (p = NS)."	3.69	Pathogenesis of glucose intolerance and diabetes mellitus in cirrhosis. ( Matthews, D; Petrides, AS; Schulze-Berge, D; Strohmeyer, G; Vogt, C, 1994)
" Glucose and lactic acid in vitreous humor and blood levels of acetone were found to be valuable indicators of antemortem hyperglycemia in diabetics."	3.69	The use of vitreous humor levels of glucose, lactic acid and blood levels of acetone to establish antemortem hyperglycemia in diabetics. ( Jobin, F; Péclet, C; Picotte, P, 1994)
" Within 5-15 min after the onset of reperfusion, the Lac/NAA peak ratio increased further in all rats; however, only in extremely hyperglycemic rats (serum glucose greater than 960 mg/dl) did the lactic acidosis progress rather than recover later during reperfusion."	3.68	Effects of hyperglycemia on the time course of changes in energy metabolism and pH during global cerebral ischemia and reperfusion in rats: correlation of 1H and 31P NMR spectroscopy with fatty acid and excitatory amino acid levels. ( Abiko, H; Faden, AI; James, TL; Weinstein, PR; Widmer, H, 1992)
"Morphometric quantitation of cerebral hemorrhage and infarction and fluorometric determinations of blood and brain tissue, glucose, glycogen, lactate, adenosine triphosphate, and phosphocreatine from 16 topographic brain sites were carried out."	3.68	Hemorrhagic infarct conversion in experimental stroke. ( de Courten-Myers, GM; DeVoe, G; Holm, P; Kleinholz, M; Myers, RE; Schmitt, G; Wagner, KR, 1992)
"The effects of hyperglycemia on muscle glycogen use and carbohydrate metabolism were evaluated in eight well-trained cyclists (average maximal O2 consumption 4."	3.68	Carbohydrate metabolism during intense exercise when hyperglycemic. ( Alonso, JG; Coyle, EF; Hamilton, MT; Ivy, JL; Montain, SJ, 1991)
"Adults with type 1 diabetes established on insulin pumps undertook HIIE and MIE stages in random order during automated insulin delivery via a closed-loop system (Medtronic)."	2.84	Closed-Loop Insulin Delivery for Adults with Type 1 Diabetes Undertaking High-Intensity Interval Exercise Versus Moderate-Intensity Exercise: A Randomized, Crossover Study. ( Gerche, A; Grosman, B; Horsburgh, JC; Jayawardene, DC; Jenkins, AJ; Kurtz, N; MacIsaac, RJ; McAuley, SA; O'Neal, DN; Roberts, TJ; Roy, A; Ward, GM, 2017)
"Besides conventional treatment for septic shock, patients in control group were given 200 mg/d hydrocortisone intravenous infusion lasting for 2 hours, while those of research group were given 8."	2.80	[The impacts of low-dose corticosteroids infusion given in different manners on refractory septic shock patients]. ( Chen, Z; He, H; He, Z; Yang, C, 2015)
"Postoperative pain was evaluated 30 min, 2, 4 and 6 h after extubation, and before discharge from the intensive care unit."	2.78	High thoracic epidural analgesia decreases stress hyperglycemia and insulin need in cardiac surgery patients. ( Greisen, J; Jakobsen, CJ; Nielsen, DV; Sloth, E, 2013)
"Poststroke hyperglycemia is common and is associated with increased risk of death and dependence, but appropriate management remains uncertain."	2.75	Randomized, controlled trial of insulin for acute poststroke hyperglycemia. ( Condon, B; Hadley, D; Macfarlane, JA; McCormick, M; McLean, JR; Muir, KW, 2010)
"Glycerol concentration was 267 +/- 41 micromol/L and 133 +/- 40 micromol/L in PF and venous blood, respectively (P = 0."	2.73	Microdialysis technique as a monitoring system for acute complications of diabetes. ( Ciechanowska, A; Foltynski, P; Karnafel, W; Kawiak, J; Krzymien, J; Ladyzynski, P; Pulawska, E; Sabalinska, S; Wojcicki, JM, 2008)
"The majority of patients with poor-grade subarachnoid hemorrhage (SAH), that is, World Federation of Neurosurgical Societies (WFNS) Grades IV and V, have high morbidity and mortality rates."	2.71	Poor-grade aneurysmal subarachnoid hemorrhage: relationship of cerebral metabolism to outcome. ( Haux, D; Küchler, I; Lanksch, WR; Sarrafzadeh, A; Unterberg, AW, 2004)
"4."	2.69	Levels of lactic acid, normal level & its relation to food, glucose, cholesterol, raised blood urea and phenformin therapy. ( Amin, BM; Patel, JC; Sawant, MS, 2000)
"Glycogen turnover was markedly reduced (I: 19 +/- 7%, II: 69 +/- 12%; P < 0."	2.68	The roles of insulin and glucagon in the regulation of hepatic glycogen synthesis and turnover in humans. ( Cline, GW; Gerow, K; Hwang, JH; Perseghin, G; Petersen, KF; Roden, M; Rothman, DL; Shulman, GI, 1996)
"Post mortem diagnosis of glucose metabolism disorders can be difficult and vague because of the lack of characteristic morphological findings."	2.47	Disorders of glucose metabolism-post mortem analyses in forensic cases: part I. ( Hess, C; Madea, B; Musshoff, F, 2011)
"We reviewed episodes of diabetic ketoacidosis from 79 diabetes patients (one episode per patient)."	1.72	Hyperlactatemia in diabetic ketoacidosis. ( Brooks, GA; Lazar, AA; Masharani, U; Strycker, LA; Wu, K, 2022)
"Tamoxifen is an effective breast cancer therapy in postmenopausal women."	1.72	Alteration in glucose metabolism in the brain associated with tamoxifen treatment: Study in postmenopausal animal model. ( Bellozi, PMQ; Itinose, AM; Koerich, S; Marek, CB; Sandrini, F; Schneider, SCS; Silva, FC, 2022)
"Hyperglycemia is associated with mortality after trauma; however, few studies have simultaneously investigated the association of depth of shock and acute hyperglycemia."	1.62	The Bitter and the Sweet: Relationship of Lactate, Glucose, and Mortality After Severe Blunt Trauma. ( Galvagno, SM; Massey, MS; Mazzeffi, MA; Richards, JE; Rock, P; Scalea, TM, 2021)
"Lactic acid oxidation was suppressed in hyperglycemic versus normoglycaemic myotubes."	1.51	Increased Glycolysis and Higher Lactate Production in Hyperglycemic Myotubes. ( Aas, V; Bakke, SS; Lund, J; Ouwens, DM; Thoresen, GH; Wettergreen, M, 2019)
"Arterial hyperglycemia is associated with poor outcome in traumatic brain injury (TBI), but the pathophysiology is not completely understood."	1.51	High Arterial Glucose is Associated with Poor Pressure Autoregulation, High Cerebral Lactate/Pyruvate Ratio and Poor Outcome Following Traumatic Brain Injury. ( Enblad, P; Hillered, L; Howells, T; Lewén, A; Ronne-Engström, E; Rostami, E; Svedung Wettervik, T, 2019)
"Hyperglycemia is a metabolic dysfunction highly associated with oxidative stress, a classical feature linked to many disorders such as diabetes mellitus."	1.51	High-glucose medium induces cellular differentiation and changes in metabolic functionality of oligodendroglia. ( Bobermin, LD; da Rosa, PM; Leite, MC; Meira, LAM; Quincozes-Santos, A; Souza, DO, 2019)
"Treatment with carvedilol restored VMH lactate levels and improved the adrenaline (epinephrine) responses."	1.51	Carvedilol prevents counterregulatory failure and impaired hypoglycaemia awareness in non-diabetic recurrently hypoglycaemic rats. ( Chan, O; Farhat, R; Fisher, SJ; Knight, N; Sejling, AS; Su, G, 2019)
"Early hyperglycemia is associated with multiple organ failure (MOF) after traumatic injury; however, few studies have considered the contribution of depth of clinical shock."	1.48	Does Lactate Affect the Association of Early Hyperglycemia and Multiple Organ Failure in Severely Injured Blunt Trauma Patients? ( Galvagno, SM; Mazzeffi, MA; Richards, JE; Rock, P; Scalea, TM, 2018)
"However, stress hyperglycemia is not predictive of early febrile seizure recurrence in the emergency department."	1.43	Children Experiencing First-Time or Prolonged Febrile Seizure Are Prone to Stress Hyperglycemia. ( Cho, HR; Kim, JH; Ko, TS; Lee, JS; Lee, JY; Ryu, JM; Yum, MS, 2016)
"Prenatal overnutrition predisposed for hyperglycaemia and hyperlactataemia, whereas undernutrition predisposed for hypercholesterolaemia upon exposure to an obesogenic diet."	1.42	Late gestation under- and overnutrition have differential impacts when combined with a post-natal obesogenic diet on glucose-lactate-insulin adaptations during metabolic challenges in adolescent sheep. ( Axel, AM; Birtwistle, M; Husted, SV; Johnsen, L; Kadarmideen, HN; Khanal, P; Kongsted, AH; Markussen, B; Nielsen, MO; Pandey, D; Pedersen, KL, 2015)
" HRT caused no adverse effects like electrolyte disturbances or hyperglycaemia."	1.42	Safety, efficacy and response to a hydrocortisone rescue therapy protocol in children with refractory hypotension after cardiopulmonal bypass. ( Gerbig, I; Grenz, Ch; Haller, Ch; Heimberg, E; Hofbeck, M; Kumpf, M; Neunhoeffer, F; Renk, H; Schlensak, Ch, 2015)
"In vivo, treatment of an ovarian cancer mouse model with metformin resulted in greater tumor weight reduction in normoglycemic vs."	1.42	Hyperglycemia-induced metabolic compensation inhibits metformin sensitivity in ovarian cancer. ( Eckert, MA; Johnson, A; Lengyel, E; Litchfield, LM; Mills, KA; Mukherjee, A; Pan, S; Romero, IL; Shridhar, V, 2015)
"Diabetes and alcohol abuse may cause severe metabolic disturbances that can be fatal."	1.39	Assessment of Traub formula and ketone bodies in cause of death investigations. ( Keltanen, T; Lindroos, K; Palo, JU; Partanen, T; Sajantila, A; Valonen, T, 2013)
"Eleven patients with type 2 diabetes participated in two experimental sessions; one was a 30-min EMS 30 min after a breakfast (EMS trial) and the other was a complete rest after a breakfast (Control trial)."	1.38	Effect of percutaneous electrical muscle stimulation on postprandial hyperglycemia in type 2 diabetes. ( Fukuda, K; Kimura, T; Matsubara, Y; Miyamoto, T; Moritani, T; Tsuda, K, 2012)
" Comparing insulin microspheres with an immediate release formulation, microspheres can increase insulin relative bioavailability up to four times."	1.37	Effect of PLGA hydrophilia on the drug release and the hypoglucemic activity of different insulin-loaded PLGA microspheres. ( Alvarez, C; de Miguel, L; Espada, R; Morales, E; Presmanes, C; Torrado, JJ, 2011)
"Hyperglycemia is an indication of poor outcome for heart attack patients, even for nondiabetic patients with stress-induced hyperglycemia."	1.36	Cardiac contractile dysfunction during acute hyperglycemia due to impairment of SERCA by polyol pathway-mediated oxidative stress. ( Cheng, WT; Chung, SK; Chung, SS; Hou, XY; Kravtsov, GM; Tang, WH; Tong, XY, 2010)
"Hypernatremia was present in five children."	1.36	Plasma glucose, lactate, sodium, and potassium levels in children hospitalized with acute alcohol intoxication. ( Kuudeberg, A; Tillmann, V; Tõnisson, M; Väli, M, 2010)
"Hyperglycemia after aneurysmal subarachnoid hemorrhage (SAH) is associated with serious complications."	1.34	Impact of hyperglycemia on neurological deficits and extracellular glucose levels in aneurysmal subarachnoid hemorrhage patients. ( Haux, D; Kerner, A; Sakowitz, O; Sarrafzadeh, A; Schlenk, F, 2007)
"Gluconeogenesis is increased in type 2 diabetes and contributes significantly to fasting and postprandial hyperglycemia."	1.33	Inhibition of fructose 1,6-bisphosphatase reduces excessive endogenous glucose production and attenuates hyperglycemia in Zucker diabetic fatty rats. ( Chandramouli, VC; Dang, Q; Erion, MD; Landau, BR; Potter, SC; van Poelje, PD, 2006)
"As suramin has been reported to induce hyperglycaemia, its effect on glucose formation has been studied in isolated rabbit hepatocytes and kidney-cortex tubules."	1.33	Suramin-induced reciprocal changes in glucose and lactate synthesis in renal tubules contribute to its hyperglycaemic action. ( Bryła, J; Jagielski, AK; Kryśkiewicz, E, 2006)
"Thus in type 2 diabetes, postprandial hyperglycemia is primarily due to increased glucose release; hyperglycemia overcomes the effects of impaired insulin secretion and sensitivity on glucose transport, but intracellular defects persist so that pathways of glucose metabolism are abnormal and glucose is shunted away from normal sites of storage (e."	1.33	Mechanisms for abnormal postprandial glucose metabolism in type 2 diabetes. ( Dostou, JM; Gerich, JE; Gosmanov, NR; Meyer, C; Szoke, E; Welle, SL; Wittlin, SD; Woerle, HJ, 2006)
"Stress hyperglycemia is frequent in critically ill patients."	1.32	Metabolic, endocrine, and immune effects of stress hyperglycemia in a rabbit model of prolonged critical illness. ( Coopmans, W; Giulietti, AP; Mathieu, C; Michalaki, M; Van den Berghe, G; Van Herck, E; Weekers, F, 2003)
" Our results demonstrate that glucose per se, but not lactate, in combination with acidosis mediates the detrimental hyperglycemic effect through a mechanism independent of ionotropic glutamate receptors."	1.32	Glucose but not lactate in combination with acidosis aggravates ischemic neuronal death in vitro. ( Asztély, F; Cronberg, T; Rytter, A; Söder, A; Wieloch, T, 2004)
"In vivo models of cerebral ischemia pose a conceptual challenge when compared to in vitro models."	1.31	Preischemic hyperglycemia-aggravated damage: evidence that lactate utilization is beneficial and glucose-induced corticosterone release is detrimental. ( Miller, JJ; Payne, RS; Schurr, A; Tseng, MT, 2001)
"Propofol has been known to suppress glucose metabolism in the brain and possess neuroprotective properties in cerebral ischaemia."	1.31	Effects of propofol on lactate accumulation and oedema formation in focal cerebral ischaemia in hyperglycaemic rats. ( Arai, T; Fukuda, K; Inubushi, T; Ishii, H; Morikawa, S; Segawa, H, 2002)
"Glycogen content was twofold higher in the left (127 +/- 33 micrograms/g tissue) than in the right kidney (56 +/- 11 micrograms/g tissue, P < 0."	1.30	Role of the kidney in plasma glucose regulation during hyperglycemia. ( Abumrad, NN; Ajmal, M; Cersosimo, E; Molina, PE; Naukam, RJ, 1997)
"We studied seven obese subjects with type 2 diabetes and seven lean and seven obese control subjects (fasting plasma glucose levels, 7."	1.30	Glucose production, utilization, and cycling in response to moderate exercise in obese subjects with type 2 diabetes and mild hyperglycemia. ( Giacca, A; Groenewoud, Y; McClean, P; Tsui, E; Zinman, B, 1998)
"The T-treated rats showed insulin resistance with both techniques, which was overcome with time and increasing insulin concentrations during the clamp measurements."	1.30	Imprinting of female offspring with testosterone results in insulin resistance and changes in body fat distribution at adult age in rats. ( Björntorp, P; Eriksson, E; Holmäng, A; Niklasson, M; Nilsson, C, 1998)
" This was associated with a 3 fold increase in insulin concentrations, even in the presence of adrenaline at a dosage which inhibits glucose-induced insulin release."	1.30	Glucose-lowering effect of BTS 67 582. ( Bailey, CJ; Page, T, 1997)
"A 64-year-old female with McArdle's disease and non-insulin-dependent diabetes mellitus (NIDDM) is reported."	1.29	McArdle's disease with non-insulin-dependent diabetes mellitus: the beneficial effects of hyperglycemia and hyperinsulinemia for exercise intolerance. ( Amano, K; Ichikawa, Y; Kono, N; Maruyama, H; Nakamoto, S; Saruta, T; Takei, I; Yamauchi, A, 1996)
"It is concluded that hyperinsulinemia and, to a lesser extent, hyperglycemia stimulate glucose conversion into lactate in adipocytes."	1.29	Effects of hyperinsulinemia and hyperglycemia on lactate release and local blood flow in subcutaneous adipose tissue of healthy humans. ( Henry, S; Jéquier, E; Schneiter, P; Tappy, L, 1996)
"Hyperglycemia is common in severely ill patients and is related principally to an increase in glucose production."	1.29	In vivo metabolic response of glucose to dichloroacetate in humans. ( Brown, JA; Gore, DC, 1996)
"Metformin treatment almost normalized glycogen levels, whereas lactate declined concomitantly in the pellet."	1.29	Demonstration of defective glucose uptake and storage in erythrocytes from non-insulin dependent diabetic patients and effects of metformin. ( Belleville, I; Martinand, A; Rapin, JR; Wiernsperger, NF; Yoa, RG, 1993)
"In hyperglycemic patients with multiple trauma, hepatic glucose production and gluconeogenesis are increased, suggesting that autoregulation of hepatic glucose production may be defective."	1.29	Effects of lactate on glucose metabolism in healthy subjects and in severely injured hyperglycemic patients. ( Cayeux, MC; Chioléro, R; Jéquier, E; Schindler, C; Schneiter, P; Tappy, L; Temler, E, 1995)
"Biguanides were found to be conducive to normalization of thrombelastogram values, not elevating the blood serum content of lactic acid even after exercise test."	1.28	[Effect of biguanides on the indicators of thrombelastography and the level of lactic acid in diabetes mellitus]. ( Babenko, AIu; Blagosklonnaia, IaV; Krasil'nikova, EI; Zaĭed, N, 1990)
"Hyperglycemia was observed during and early after operation in both groups."	1.28	Preservation of pancreatic beta cell function with pulsatile cardiopulmonary bypass. ( Funakoshi, N; Innami, R; Murayama, F; Nagaoka, H; Satoh, M; Watanabe, M, 1989)
"Hyperglycemia was found consistently within 12 hours after injury (224 +/- 98 mg/dl, P less than 0."	1.27	Hyperglycemia, cerebrospinal fluid lactic acidosis, and cerebral blood flow in severely head-injured patients. ( De Salles, AA; Muizelaar, JP; Young, HF, 1987)
"In diazinon-treated hyperglycaemic animals, the glycogen content of the brain was depleted, the activities of glycogen phosphorylase, phosphoglucomutase and hexokinase were significantly increased and the activity of glucose-6-phosphatase remained unchanged."	1.27	Changes in cerebral glycogenolysis and related enzymes in diazinon treated hyperglycaemic animals. ( Husain, K; Matin, MA, 1987)
"Hyperglycemia was induced by intraperitoneal injection of 50% glucose and same volume of 50% D-mannitol or physiological saline were injected intraperitoneally 20 minutes before MCA occlusion in control rats."	1.27	[The effect of hyperglycemia on ischemic brain damage: relevance to the local cerebral blood flow]. ( Aizawa, S; Kojima, M; Sako, K; Suzuki, N; Yonemasu, Y; Yura, S, 1986)
"Terbutaline (T) is a beta-adrenergic compound which is commonly employed as a tocolytic agent in preterm labor."	1.26	The effects of terbutaline on acid base, serum electrolytes, and glucose homeostasis during the management of preterm labor. ( Cotton, DB; Goldstein, DA; Lipson, LG; Strassner, HT, 1981)

Research

Studies (199)

Authors

Clinical Trials (6)

Trial Overview

Trial Outcomes

Change in Augmentation Index Between Baseline and After 2 Hour Insulin Clamp

Timeframe	Studies, this research(%)	All Research%
pre-1990	20 (10.05)	18.7374
1990's	50 (25.13)	18.2507
2000's	64 (32.16)	29.6817
2010's	55 (27.64)	24.3611
2020's	10 (5.03)	2.80

Authors	Studies
Hostiuc, S	1
Negoi, I	1
Hostiuc, M	1
Masharani, U	1
Strycker, LA	1
Lazar, AA	1
Wu, K	1
Brooks, GA	1
Baryła, I	1
Styczeń-Binkowska, E	1
Płuciennik, E	1
Kośla, K	1
Bednarek, AK	1
Koerich, S	1
Silva, FC	1
Itinose, AM	1
Bellozi, PMQ	1
Sandrini, F	1
Schneider, SCS	1
Marek, CB	1
Galderisi, A	2
Tordin, M	2
Suppiej, A	2
Cainelli, E	2
Baraldi, E	2
Trevisanuto, D	2
Fitzgerald, O	1
Perez-Concha, O	1
Gallego-Luxan, B	1
Rudd, L	1
Jorm, L	1
Lund, J	1
Ouwens, DM	1
Wettergreen, M	1
Bakke, SS	1
Thoresen, GH	1
Aas, V	1
Jenei, K	1
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Trial	Phase	Enrollment	Study Type	Start Date	Status
Evaluation of the Effects of Electrical Muscle Stimulation on Carbohydrate Homeostasis in Adult Patients With Obesity[NCT04643899]		60 participants (Actual)	Interventional	2021-03-29	Completed
Effect of Hyperglycemia on Microvascular Perfusion in Healthy Adults[NCT03520569]	Early Phase 1	15 participants (Actual)	Interventional	2019-02-04	Completed
Determining the Factors That Affects Emergency Department Visits of Hyperglycemic Patients in 30 Days.[NCT04665128]		120 participants (Anticipated)	Observational	2020-12-15	Recruiting
Phase 1 Study To Determine the Effects of Short Term Near-infrared Light (NIR) Therapy on Anatomic and Functional Abnormalities of Diabetic Macular Edema, and Assess Safety of Short Term Near-infrared Light Therapy in Eyes With Diabetic Macular Edema.[NCT00846092]	Phase 1	4 participants (Actual)	Interventional	2007-11-30	Completed
A Novel Non-Invasive In Vivo Imaging System to Measure Retinal Metabolism[NCT00385333]	Phase 2	28 participants (Actual)	Interventional	2006-09-29	Completed
An Acute Randomized Dose-finding Equivalence Trial of Small, Catalytic Doses of Fructose and Allulose on Postprandial Carbohydrate Metabolism: The Fructose and Allulose Catalytic Effects (FACE) Study[NCT02459834]		50 participants (Actual)	Interventional	2015-11-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

The augmentation index (AIx) measured at the radial artery is a measure of systemic arterial stiffness, and is defined as the ratio of augmentation (Δ P) to central pulse pressure and expressed as percent. AIx = (ΔP/PP) x 100, where P = pressure and PP = Pulse Pressure. Higher percentages indicate increased arterial stiffness. (NCT03520569)
Timeframe: baseline and after 2 hour insulin clamp

Change in Flow Mediated Dilation (FMD) Between Baseline and After 2 Hour Insulin Clamp

Intervention	percentage (Mean)
Octreotide- Euglycemia	-4.15
Octreotide - Euglycemia- Insulin Clamp	-2.23
Octreotide- Hyperglycemia	-4.80
Octreotide- Hyperglycemia - Insulin Clamp	-8.45

Flow mediated dilation measures the change in brachial diameter in response to 5 minutes of ischemia using B-mode ultrasound. It provides an index of nitric oxide generation by the endothelium . (NCT03520569)
Timeframe: baseline and after 2 hour insulin clamp

Change in Pulse Wave Velocity (PWV) Between Baseline and After 2 Hour Insulin Clamp

Intervention	% change (Mean)
Octreotide- Euglycemia	11.8
Octreotide - Euglycemia- Insulin Clamp	11.8
Octreotide- Hyperglycemia	8.9
Octreotide- Hyperglycemia - Insulin Clamp	8.95

The time required for a blood pressure wave to travel from the carotid to the femoral artery was measured in meter/sec. This is a measurement of central artery stiffness. Higher numbers indicate stiffer vessels (NCT03520569)
Timeframe: baseline and after 2 hour insulin clamp

Article	Year
Markers of hyperglycemia in the vitreous humor. A systematic review and meta-analysis. Journal of forensic and legal medicine, 2021, Volume: 83 Topics: 3-Hydroxybutyric Acid; Biomarkers; Deoxyglucose; Forensic Medicine; Fructosamine; Glucose; Humans; H	2021
COVID-19 and diabetes: the contributions of hyperglycemia. Journal of molecular cell biology, 2020, 09-07, Volume: 12, Issue:12 Topics: Angiotensin-Converting Enzyme 2; Blood Glucose; COVID-19; Cytokine Release Syndrome; Diabetes Compli	2020
Critical care of burn patients. New approaches to old problems. Burns : journal of the International Society for Burn Injuries, 2016, Volume: 42, Issue:1 Topics: Burns; Critical Care; Extracorporeal Membrane Oxygenation; Fluid Therapy; Hemodynamics; Humans; Hype	2016
Metabolic and electrolyte disturbance after cardiac arrest: How to deal with it. Best practice & research. Clinical anaesthesiology, 2015, Volume: 29, Issue:4 Topics: Blood Glucose; Electrolytes; Heart Arrest; Humans; Hyperglycemia; Lactic Acid; Metabolic Diseases; W	2015
Management of sepsis in the ICU. International anesthesiology clinics, 2009,Winter, Volume: 47, Issue:1 Topics: Adrenal Cortex Hormones; Anti-Infective Agents; Critical Care; Humans; Hyperglycemia; Hypoglycemic A	2009
Disorders of glucose metabolism-post mortem analyses in forensic cases: part I. International journal of legal medicine, 2011, Volume: 125, Issue:2 Topics: Blood Proteins; Diabetes Mellitus; Diabetic Ketoacidosis; Forensic Pathology; Fructosamine; Glucose;	2011
Pathophysiologic changes due to TASER® devices versus excited delirium: potential relevance to deaths-in-custody? Journal of forensic and legal medicine, 2011, Volume: 18, Issue:4 Topics: Acidosis; Animals; Blood Glucose; Body Temperature; Catecholamines; Channelopathies; Conducted Energ	2011
Trauma and aggressive homeostasis management. Anesthesiology clinics, 2013, Volume: 31, Issue:1 Topics: Acidosis, Lactic; Brain Injuries; Homeostasis; Humans; Hyperglycemia; Hypothermia, Induced; Insulin;	2013
Lactate, glucose and energy metabolism in the ischemic brain (Review). International journal of molecular medicine, 2002, Volume: 10, Issue:2 Topics: Acidosis, Lactic; Anaerobiosis; Animals; Brain; Brain Damage, Chronic; Brain Ischemia; Corticosteron	2002
Therapeutic potential of the mammalian pyruvate dehydrogenase kinases in the prevention of hyperglycaemia. Current drug targets. Immune, endocrine and metabolic disorders, 2002, Volume: 2, Issue:2 Topics: Animals; Glucose; Humans; Hyperglycemia; Islets of Langerhans; Isoenzymes; Lactic Acid; Liver; Muscl	2002
Trauma and aggressive homeostasis management. Anesthesiology clinics, 2007, Volume: 25, Issue:1 Topics: Acidosis; Animals; Brain Injuries; Homeostasis; Humans; Hyperglycemia; Hypothermia; Lactic Acid; Sho	2007
Glucose metabolism and catecholamines. Critical care medicine, 2007, Volume: 35, Issue:9 Suppl Topics: Adrenergic beta-Agonists; Animals; Carbohydrate Metabolism; Catecholamines; Glucose; Glycolysis; Hum	2007

Article	Year
Closed-Loop Insulin Delivery for Adults with Type 1 Diabetes Undertaking High-Intensity Interval Exercise Versus Moderate-Intensity Exercise: A Randomized, Crossover Study. Diabetes technology & therapeutics, 2017, Volume: 19, Issue:6 Topics: Adult; Biomarkers; Blood Glucose; Combined Modality Therapy; Cross-Over Studies; Diabetes Mellitus,	2017
Simulated games activity vs continuous running exercise: a novel comparison of the glycemic and metabolic responses in T1DM patients. Scandinavian journal of medicine & science in sports, 2015, Volume: 25, Issue:2 Topics: Adult; Biomarkers; Blood Glucose; Diabetes Mellitus, Type 1; Exercise Therapy; Female; Games, Recrea	2015
[The impacts of low-dose corticosteroids infusion given in different manners on refractory septic shock patients]. Zhonghua wei zhong bing ji jiu yi xue, 2015, Volume: 27, Issue:6 Topics: Adrenal Cortex Hormones; Arterial Pressure; Central Venous Pressure; Hemodynamics; Humans; Hyperglyc	2015
Accuracy of Continuous Glucose Monitoring (CGM) during Continuous and High-Intensity Interval Exercise in Patients with Type 1 Diabetes Mellitus. Nutrients, 2016, Aug-10, Volume: 8, Issue:8 Topics: Adult; Bicycling; Blood Glucose; Combined Modality Therapy; Diabetes Mellitus, Type 1; Diet, Diabeti	2016
[Effect of blood glucose control on level of lactic acid in patients with cardic-valve replacement]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2009, Volume: 34, Issue:5 Topics: Adult; Cardiopulmonary Bypass; Double-Blind Method; Female; Heart Valve Prosthesis Implantation; Hum	2009
Randomized, controlled trial of insulin for acute poststroke hyperglycemia. Annals of neurology, 2010, Volume: 67, Issue:5 Topics: Acute Disease; Aged; Aged, 80 and over; Analysis of Variance; Blood Glucose; Brain Infarction; Creat	2010
Intermittent exercise with and without hypoxia improves insulin sensitivity in individuals with type 2 diabetes. The Journal of clinical endocrinology and metabolism, 2012, Volume: 97, Issue:4 Topics: Algorithms; Blood Glucose; Cross-Over Studies; Deuterium; Diabetes Mellitus, Type 2; Exercise; Gluco	2012
High thoracic epidural analgesia decreases stress hyperglycemia and insulin need in cardiac surgery patients. Acta anaesthesiologica Scandinavica, 2013, Volume: 57, Issue:2 Topics: Aged; Analgesia, Epidural; Autonomic Nerve Block; Blood Glucose; Cardiac Surgical Procedures; Cardio	2013
Poor-grade aneurysmal subarachnoid hemorrhage: relationship of cerebral metabolism to outcome. Journal of neurosurgery, 2004, Volume: 100, Issue:3 Topics: Brain; Disability Evaluation; Female; Glasgow Coma Scale; Glucose; Glutamic Acid; Humans; Hyperglyce	2004
Microdialysis technique as a monitoring system for acute complications of diabetes. Artificial organs, 2008, Volume: 32, Issue:1 Topics: Abdominal Fat; Adult; Aged; Aged, 80 and over; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2;	2008
Perioperative hyperinsulinaemic normoglycaemic clamp causes hypolipidaemia after coronary artery surgery. British journal of anaesthesia, 2008, Volume: 100, Issue:4 Topics: Aged; Blood Glucose; Coronary Artery Bypass; Dyslipidemias; Fatty Acids, Nonesterified; Female; Gluc	2008
The roles of insulin and glucagon in the regulation of hepatic glycogen synthesis and turnover in humans. The Journal of clinical investigation, 1996, Feb-01, Volume: 97, Issue:3 Topics: Adult; Amino Acids; C-Peptide; Fatty Acids, Nonesterified; Gastrointestinal Agents; Glucagon; Glucos	1996
Effects of losartan on insulin sensitivity in hypertensive subjects. Hypertension (Dallas, Tex. : 1979), 1996, Volume: 28, Issue:3 Topics: Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Double-Blind Method; Fatty Acids, Nones	1996
Observations on the relationships between plasma free fatty acids, ketones and bicarbonate in acute hyperglycaemia. Annals of clinical biochemistry, 1997, Volume: 34 ( Pt 3) Topics: Adolescent; Adult; Aged; Aged, 80 and over; Bicarbonates; Child; Fatty Acids; Female; Humans; Hyperg	1997
Enhancement of alcohol-induced hypoglycaemia by H2-receptor antagonists. Arzneimittel-Forschung, 1997, Volume: 47, Issue:6 Topics: Acetaldehyde; Anti-Ulcer Agents; Blood Glucose; Cimetidine; Drug Synergism; Ethanol; Famotidine; His	1997
Levels of lactic acid, normal level & its relation to food, glucose, cholesterol, raised blood urea and phenformin therapy. Indian journal of medical sciences, 2000, Volume: 54, Issue:1 Topics: Diabetes Mellitus, Type 2; Diet; Female; Humans; Hypercholesterolemia; Hyperglycemia; India; Lactic	2000

Article	Year
Hyperlactatemia in diabetic ketoacidosis. Diabetic medicine : a journal of the British Diabetic Association, 2022, Volume: 39, Issue:4 Topics: 3-Hydroxybutyric Acid; Blood Glucose; Diabetes Mellitus; Diabetic Ketoacidosis; Humans; Hyperglycemi	2022
The International journal of molecular sciences, 2022, Mar-19, Volume: 23, Issue:6 Topics: Animals; Down-Regulation; Glucose; Glycolysis; Humans; Hyperglycemia; Hypoxia; Hypoxia-Inducible Fac	2022
Alteration in glucose metabolism in the brain associated with tamoxifen treatment: Study in postmenopausal animal model. Toxicology and applied pharmacology, 2022, 05-01, Volume: 442 Topics: Animals; Disease Models, Animal; Female; Glucose; Hippocampus; Humans; Hyperglycemia; Lactic Acid; P	2022
Glucose-to-lactate ratio and neurodevelopment in infants with hypoxic-ischemic encephalopathy: an observational study. European journal of pediatrics, 2023, Volume: 182, Issue:2 Topics: Glucose; Humans; Hyperglycemia; Hypoglycemia; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Infant;	2023
Glucose-to-lactate ratio and neurodevelopment in infants with hypoxic-ischemic encephalopathy: an observational study. European journal of pediatrics, 2023, Volume: 182, Issue:2 Topics: Glucose; Humans; Hyperglycemia; Hypoglycemia; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Infant;	2023
Glucose-to-lactate ratio and neurodevelopment in infants with hypoxic-ischemic encephalopathy: an observational study. European journal of pediatrics, 2023, Volume: 182, Issue:2 Topics: Glucose; Humans; Hyperglycemia; Hypoglycemia; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Infant;	2023
Glucose-to-lactate ratio and neurodevelopment in infants with hypoxic-ischemic encephalopathy: an observational study. European journal of pediatrics, 2023, Volume: 182, Issue:2 Topics: Glucose; Humans; Hyperglycemia; Hypoglycemia; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Infant;	2023
The relationship between hyperglycaemia on admission and patient outcome is modified by hyperlactatemia and diabetic status: a retrospective analysis of the eICU collaborative research database. Scientific reports, 2023, 09-21, Volume: 13, Issue:1 Topics: Blood Glucose; Diabetes Mellitus; Humans; Hyperglycemia; Hyperlactatemia; Lactic Acid; Retrospective	2023
Increased Glycolysis and Higher Lactate Production in Hyperglycemic Myotubes. Cells, 2019, 09-18, Volume: 8, Issue:9 Topics: Adult; Cells, Cultured; Female; Glycolysis; Healthy Volunteers; Humans; Hyperglycemia; Lactic Acid;	2019
[Changes of lactate levels in diabetic ketoacidosis and in newly diagnosed type 1 diabetes mellitus]. Orvosi hetilap, 2019, Volume: 160, Issue:45 Topics: Blood Gas Analysis; Child; Child, Preschool; Diabetes Mellitus, Type 1; Diabetic Ketoacidosis; Femal	2019
The Bitter and the Sweet: Relationship of Lactate, Glucose, and Mortality After Severe Blunt Trauma. Anesthesia and analgesia, 2021, 08-01, Volume: 133, Issue:2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers; Blood Glucose; Female; Hospital Mortality; H	2021
Role of insulin/glucagon ratio and cell redox state in the hyperglycaemia induced by exposure to a 60-Hz magnetic field in rats. Scientific reports, 2021, 06-03, Volume: 11, Issue:1 Topics: Animals; Biomarkers; Disease Models, Animal; Disease Susceptibility; Electromagnetic Fields; Energy	2021
The Metabolopathy of Tissue Injury, Hemorrhagic Shock, and Resuscitation in a Rat Model. Shock (Augusta, Ga.), 2018, Volume: 49, Issue:5 Topics: Animals; Disease Models, Animal; Glycolysis; Hyperglycemia; Lactic Acid; Male; Metabolomics; Rats; R	2018
Severe type B lactic acidosis and insulin-resistant hyperglycemia related to cadaveric kidney transplantation. Journal of clinical anesthesia, 2018, Volume: 44 Topics: Acidosis, Lactic; Blood Glucose; Hemofiltration; Humans; Hyperglycemia; Insulin; Kidney Failure, Chr	2018
Does Lactate Affect the Association of Early Hyperglycemia and Multiple Organ Failure in Severely Injured Blunt Trauma Patients? Anesthesia and analgesia, 2018, Volume: 126, Issue:3 Topics: Adult; Biomarkers; Blood Glucose; Cohort Studies; Female; Humans; Hyperglycemia; Injury Severity Sco	2018
Hyperglycemia and Elevated Lactate in Trauma: Where Do We Go From Here? Anesthesia and analgesia, 2018, Volume: 126, Issue:3 Topics: Humans; Hyperglycemia; Lactic Acid; Multiple Organ Failure; Wounds, Nonpenetrating	2018
Tyrosine kinase inhibitor imatinib modulates the viability and apoptosis of castrate-resistant prostate cancer cells dependently on the glycolytic environment. Life sciences, 2019, Feb-01, Volume: 218 Topics: Apoptosis; Cell Proliferation; Glucose; Glycolysis; Humans; Hyperglycemia; Imatinib Mesylate; Lactic	2019
Carvedilol prevents counterregulatory failure and impaired hypoglycaemia awareness in non-diabetic recurrently hypoglycaemic rats. Diabetologia, 2019, Volume: 62, Issue:4 Topics: Adrenergic beta-1 Receptor Antagonists; Animals; Blood Glucose; Body Weight; Carvedilol; Catheteriza	2019
Profound Changes in Net Energy and Nitrogen Metabolites Fluxes within the Splanchnic Area during Overfeeding of Yucatan Mini Pigs That Remain Euglycemic. Nutrients, 2019, Feb-19, Volume: 11, Issue:2 Topics: Adaptation, Physiological; Amino Acids; Animals; Bile; Blood Glucose; Carbohydrate Metabolism; Energ	2019
[Blood group as a predictor of glycemia and lactatemia in critical condition patients.] Klinicheskaia laboratornaia diagnostika, 2019, Volume: 64, Issue:4 Topics: Adult; Aged; Blood Glucose; Blood Group Antigens; Case-Control Studies; Critical Illness; Humans; Hy	2019
High Arterial Glucose is Associated with Poor Pressure Autoregulation, High Cerebral Lactate/Pyruvate Ratio and Poor Outcome Following Traumatic Brain Injury. Neurocritical care, 2019, Volume: 31, Issue:3 Topics: Adult; Arterial Pressure; Blood Glucose; Blood Pressure; Brain; Brain Injuries, Traumatic; Cerebrova	2019
High-glucose medium induces cellular differentiation and changes in metabolic functionality of oligodendroglia. Molecular biology reports, 2019, Volume: 46, Issue:5 Topics: Animals; Biomarkers; Blood Glucose; Cell Differentiation; Cell Survival; Energy Metabolism; Glucose;	2019
Glycogenic Hepatopathy Causing Elevated Lactic Acid and Liver Enzymes. The American journal of medicine, 2020, Volume: 133, Issue:2 Topics: Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Blood Glucose; Diabetes Mel	2020
Effects of intraportal exenatide on hepatic glucose metabolism in the conscious dog. American journal of physiology. Endocrinology and metabolism, 2013, Jul-01, Volume: 305, Issue:1 Topics: Animals; Consciousness; Dogs; Exenatide; Female; Glucose; Hyperglycemia; Hypoglycemic Agents; Infusi	2013
Assessment of Traub formula and ketone bodies in cause of death investigations. International journal of legal medicine, 2013, Volume: 127, Issue:6 Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Alcoholism; Algorithms; Autopsy; Biomarkers; Blood Gl	2013
Stress hyperlactatemia modifies the relationship between stress hyperglycemia and outcome: a retrospective observational study. Critical care medicine, 2014, Volume: 42, Issue:6 Topics: Aged; APACHE; Blood Gas Analysis; Critical Illness; Cross-Sectional Studies; Female; Glucose; Hospit	2014
Lactate and glucose in critically ill patients: what goes around, comes around. Critical care medicine, 2014, Volume: 42, Issue:6 Topics: Critical Illness; Female; Glucose; Humans; Hyperglycemia; Lactic Acid; Male; Stress, Physiological	2014
Influence of gas stunning and halal slaughter (no stunning) on rabbits welfare indicators and meat quality. Meat science, 2014, Volume: 98, Issue:4 Topics: Abattoirs; Animal Welfare; Animals; Carbon Dioxide; Catecholamines; Food Quality; Gases; Glycogen; H	2014
Late gestation under- and overnutrition have differential impacts when combined with a post-natal obesogenic diet on glucose-lactate-insulin adaptations during metabolic challenges in adolescent sheep. Acta physiologica (Oxford, England), 2015, Volume: 213, Issue:2 Topics: Adaptation, Physiological; Aging; Animals; Diet; Fasting; Female; Glucose; Hyperglycemia; Insulin; L	2015
Safety, efficacy and response to a hydrocortisone rescue therapy protocol in children with refractory hypotension after cardiopulmonal bypass. Pediatric cardiology, 2015, Volume: 36, Issue:3 Topics: Adolescent; Age Factors; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Child; Child, Preschoo	2015
Evaluation of the Dual-Chamber Pen Design for the Injection of Exenatide Once Weekly for the Treatment of Type 2 Diabetes. Journal of diabetes science and technology, 2015, Volume: 9, Issue:4 Topics: Adult; Device Approval; Diabetes Mellitus, Type 2; Drug Administration Schedule; Equipment Design; E	2015
Hyperglycemia-induced metabolic compensation inhibits metformin sensitivity in ovarian cancer. Oncotarget, 2015, Sep-15, Volume: 6, Issue:27 Topics: Animals; Antineoplastic Agents; Ascites; Cell Line, Tumor; Cell Survival; Female; Gene Expression Re	2015
Children Experiencing First-Time or Prolonged Febrile Seizure Are Prone to Stress Hyperglycemia. Journal of child neurology, 2016, Volume: 31, Issue:4 Topics: Child, Preschool; Female; Humans; Hydrogen-Ion Concentration; Hyperglycemia; Infant; Lactic Acid; Ma	2016
Response of lactate metabolism in brain glucosensing areas of rainbow trout (Oncorhynchus mykiss) to changes in glucose levels. Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2015, Volume: 185, Issue:8 Topics: Adaptation, Physiological; Animals; Astrocytes; Brain; Energy Metabolism; Enzymes; Fish Proteins; Ge	2015
Pyruvate Dehydrogenase Kinase-mediated Glycolytic Metabolic Shift in the Dorsal Root Ganglion Drives Painful Diabetic Neuropathy. The Journal of biological chemistry, 2016, Mar-11, Volume: 291, Issue:11 Topics: Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Ganglia, Spinal; G	2016
[For diabetics sports are more strenuous]. MMW Fortschritte der Medizin, 2016, Mar-17, Volume: 158, Issue:5 Topics: Diabetes Mellitus, Type 2; Humans; Hyperglycemia; Insulin Resistance; Lactic Acid; Oxygen; Physical	2016
A Rare Case of Caffeine Storm due to Excessive Coca-Cola Consumption. The Israel Medical Association journal : IMAJ, 2016, Volume: 18, Issue:6 Topics: Adult; Caffeine; Central Nervous System Stimulants; Diabetic Ketoacidosis; Diagnosis, Differential;	2016
Effects of AMPK activation on lipolysis in primary rat adipocytes: studies at different glucose concentrations. Archives of physiology and biochemistry, 2017, Volume: 123, Issue:1 Topics: Absorption, Physiological; Adipocytes; Adrenergic Agonists; Aminoimidazole Carboxamide; AMP-Activate	2017
The reversal of hyperglycaemia in diabetic mice using PLGA scaffolds seeded with islet-like cells derived from human embryonic stem cells. Biomaterials, 2009, Volume: 30, Issue:9 Topics: Animals; Biomarkers; Blood Glucose; Cell Differentiation; Cell Shape; Diabetes Mellitus, Experimenta	2009
Metabolic fate of plasma glucose during hyperglycemia in impaired glucose tolerance: evidence for further early defects in the pathogenesis of type 2 diabetes. American journal of physiology. Endocrinology and metabolism, 2009, Volume: 296, Issue:3 Topics: Alanine; Blood Glucose; Diabetes Mellitus, Type 2; Fatty Acids, Nonesterified; Female; Glucagon; Glu	2009
Postmortem identification of hyperglycemia. Forensic science international, 2009, Mar-10, Volume: 185, Issue:1-3 Topics: Blood Gas Analysis; Diabetic Coma; Female; Forensic Pathology; Glucose; Humans; Hyperglycemia; Lacti	2009
Postprocedural hyperglycemia in ST elevation myocardial infarction submitted to percutaneous coronary intervention: a prognostic indicator and a marker of metabolic derangement. Journal of cardiovascular medicine (Hagerstown, Md.), 2010, Volume: 11, Issue:1 Topics: Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Biomarkers; Blood Glucose; Blood Sedimentat	2010
Temporal features of magnetic resonance imaging and spectroscopy in non-ketotic hyperglycemic chorea-ballism patients. European journal of neurology, 2010, Volume: 17, Issue:4 Topics: Acute Disease; Aged; Basal Ganglia; Choline; Chorea; Creatine; Female; Follow-Up Studies; Functional	2010
Cardiac contractile dysfunction during acute hyperglycemia due to impairment of SERCA by polyol pathway-mediated oxidative stress. American journal of physiology. Cell physiology, 2010, Volume: 299, Issue:3 Topics: Acute Disease; Aldehyde Reductase; Animals; Calcium Signaling; Glucose; Glutathione; Heart; Hypergly	2010
Plasma glucose, lactate, sodium, and potassium levels in children hospitalized with acute alcohol intoxication. Alcohol (Fayetteville, N.Y.), 2010, Volume: 44, Issue:6 Topics: Adolescent; Alcoholic Intoxication; Blood Glucose; Child; Ethanol; Female; Hospitalization; Humans;	2010
Comparison of lymphomononuclear cell energy metabolism between healthy, impaired glucose intolerance and type 2 diabetes mellitus patients. Endocrine, 2010, Volume: 37, Issue:1 Topics: Aged; Blood Glucose; Cells, Cultured; Diabetes Mellitus, Type 2; Energy Metabolism; Female; Glucose	2010
[Perioperative monitoring and control of hyperglycemia during deep hypothermic circulatory arrest]. Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue, 2011, Volume: 23, Issue:7 Topics: Blood Glucose; Circulatory Arrest, Deep Hypothermia Induced; Female; Humans; Hyperglycemia; Lactic A	2011
Effect of PLGA hydrophilia on the drug release and the hypoglucemic activity of different insulin-loaded PLGA microspheres. Journal of microencapsulation, 2011, Volume: 28, Issue:8 Topics: Animals; Delayed-Action Preparations; Drug Carriers; Drug Compounding; Hydrophobic and Hydrophilic I	2011
Electroacupuncture stimulation using different frequencies (10 and 100 Hz) changes the energy metabolism in induced hyperglycemic rats. Acta cirurgica brasileira, 2011, Volume: 26 Suppl 1 Topics: Acupuncture Points; Animals; Disease Models, Animal; Electroacupuncture; Energy Metabolism; Hypergly	2011
Effect of percutaneous electrical muscle stimulation on postprandial hyperglycemia in type 2 diabetes. Diabetes research and clinical practice, 2012, Volume: 96, Issue:3 Topics: Analysis of Variance; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Electric Stimulation; Hum	2012
Insights into the mechanisms mediating hyperglycemic and stressogenic outcomes in rats treated with monocrotophos, an organophosphorus insecticide. Toxicology, 2012, Mar-29, Volume: 294, Issue:1 Topics: Animals; Atropine; Blood Glucose; Corticosterone; Enzyme Induction; Epinephrine; Hyperglycemia; Inse	2012
Effects of hyperglycemia and effects of ketosis on cerebral perfusion, cerebral water distribution, and cerebral metabolism. Diabetes, 2012, Volume: 61, Issue:7 Topics: Adenosine Triphosphate; Animals; Aspartic Acid; Brain Edema; Cerebrum; Diabetes Mellitus, Experiment	2012
Glucose and fatty acid metabolism in a 3 tissue in-vitro model challenged with normo- and hyperglycaemia. PloS one, 2012, Volume: 7, Issue:4 Topics: Adipose Tissue; Cell Survival; E-Selectin; Fatty Acids; Glucose; Hepatocytes; Human Umbilical Vein E	2012
Role of hyperglycemia-mediated erythrocyte redox state alteration in the development of diabetic retinopathy. Retina (Philadelphia, Pa.), 2013, Volume: 33, Issue:1 Topics: Blood Glucose; Blood Pressure; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diabetic Retinopa	2013
Alteration of hypothalamic glucose and lactate sensing in 48h hyperglycemic rats. Neuroscience letters, 2013, Feb-08, Volume: 534 Topics: Animals; Glucose; Hyperglycemia; Hypothalamus; Insulin; Insulin Secretion; Lactic Acid; Male; Monoca	2013
Ameliorative effects of Syzygium jambolanum extract and its poly (lactic-co-glycolic) acid nano-encapsulated form on arsenic-induced hyperglycemic stress: a multi-parametric evaluation. Journal of acupuncture and meridian studies, 2012, Volume: 5, Issue:6 Topics: Animals; Arsenic; Blood-Brain Barrier; Cell Line; Female; Hyperglycemia; Hypoglycemic Agents; Lactic	2012
Poly(lactic-co-glycolic) acid loaded nano-insulin has greater potentials of combating arsenic induced hyperglycemia in mice: some novel findings. Toxicology and applied pharmacology, 2013, Feb-15, Volume: 267, Issue:1 Topics: Animals; Arsenic; Blood-Brain Barrier; Drug Carriers; Female; Hyperglycemia; Insulin; Lactic Acid; M	2013
Correlation between blood glucose concentration and glucose concentration in subcutaneous adipose tissue evaluated with microdialysis during intensive care. Scandinavian journal of clinical and laboratory investigation, 2002, Volume: 62, Issue:4 Topics: Adipose Tissue; Blood Glucose; Brain Injuries; Critical Care; Energy Metabolism; Glycerol; Humans; H	2002
Brain glucose levels are elevated in chronically hyperglycemic diabetic rats: no evidence for protective adaptation by the blood brain barrier. Metabolism: clinical and experimental, 2002, Volume: 51, Issue:12 Topics: 3-Hydroxybutyric Acid; Acute Disease; Adaptation, Physiological; Animals; Blood-Brain Barrier; Brain	2002
Effect of hyperglycemia and fatty acid oxidation inhibition during aerobic conditions and demand-induced ischemia. American journal of physiology. Heart and circulatory physiology, 2003, Volume: 284, Issue:5 Topics: Animals; Coronary Circulation; Disease Models, Animal; Fatty Acids, Nonesterified; Glycogen; Glycoly	2003
Effects of 2-deoxy-d-glucose on focal cerebral ischemia in hyperglycemic rats. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2003, Volume: 23, Issue:5 Topics: Animals; Antimetabolites; Aspartic Acid; Deoxyglucose; Hyperglycemia; Infarction, Middle Cerebral Ar	2003
Metabolic, endocrine, and immune effects of stress hyperglycemia in a rabbit model of prolonged critical illness. Endocrinology, 2003, Volume: 144, Issue:12 Topics: Alloxan; Animals; Blood Gas Analysis; Blood Glucose; Body Weight; Burns; Critical Illness; Diabetes	2003
Effects of hyperglycemia on hepatic gluconeogenic flux during glycogen phosphorylase inhibition in the conscious dog. American journal of physiology. Endocrinology and metabolism, 2004, Volume: 286, Issue:4 Topics: Amino Acids; Animals; Dihydropyridines; Dogs; Enzyme Inhibitors; Female; Fructosephosphates; Furans;	2004
Glucose but not lactate in combination with acidosis aggravates ischemic neuronal death in vitro. Stroke, 2004, Volume: 35, Issue:3 Topics: Acidosis; Animals; Brain Ischemia; Cell Death; Dose-Response Relationship, Drug; Excitatory Amino Ac	2004
The effect of hyperglycemia on experimental retinal ischemia. Archives of ophthalmology (Chicago, Ill. : 1960), 2004, Volume: 122, Issue:3 Topics: Animals; Blood Glucose; Cyclophilins; Deoxyglucose; Diabetes Mellitus, Experimental; Electroretinogr	2004
Effects of hyperglycemia, glucagon, and epinephrine on renal glucose release in the conscious dog. Metabolism: clinical and experimental, 2004, Volume: 53, Issue:7 Topics: Amino Acids; Animals; Blood Glucose; Dogs; Epinephrine; Female; Glucagon; Gluconeogenesis; Glucose;	2004
Interactions between hyperglycemia and hypoxia: implications for diabetic retinopathy. Diabetes, 2004, Volume: 53, Issue:11 Topics: Animals; Cell Hypoxia; Cornea; Diabetic Retinopathy; Glucose; Hyperglycemia; Lactic Acid; Male; Mito	2004
Interactions between hyperglycemia and hypoxia: implications for diabetic retinopathy. Diabetes, 2004, Volume: 53, Issue:11 Topics: Animals; Cell Hypoxia; Cornea; Diabetic Retinopathy; Glucose; Hyperglycemia; Lactic Acid; Male; Mito	2004
Interactions between hyperglycemia and hypoxia: implications for diabetic retinopathy. Diabetes, 2004, Volume: 53, Issue:11 Topics: Animals; Cell Hypoxia; Cornea; Diabetic Retinopathy; Glucose; Hyperglycemia; Lactic Acid; Male; Mito	2004
Interactions between hyperglycemia and hypoxia: implications for diabetic retinopathy. Diabetes, 2004, Volume: 53, Issue:11 Topics: Animals; Cell Hypoxia; Cornea; Diabetic Retinopathy; Glucose; Hyperglycemia; Lactic Acid; Male; Mito	2004
Regulation of pyruvate dehydrogenase activity and citric acid cycle intermediates during high cardiac power generation. The Journal of physiology, 2005, Jan-15, Volume: 562, Issue:Pt 2 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Cardiotonic Agents; Carnitine O-Palmitoyltra	2005
The effects of peroxovanadate and peroxovanadyl on glucose metabolism in vivo and identification of signal transduction proteins involved in the mechanism of action in isolated soleus muscle. Molecular and cellular biochemistry, 2005, Volume: 273, Issue:1-2 Topics: Animals; Diabetes Mellitus, Experimental; Glucose; Glycogen; Hyperglycemia; Hypoglycemic Agents; Ins	2005
The effect of clonidine on cell survival, glutamate, and aspartate release in normo- and hyperglycemic rats after near complete forebrain ischemia. Experimental brain research, 2005, Volume: 167, Issue:4 Topics: Adrenergic alpha-Agonists; Animals; Aspartic Acid; Blood Glucose; Blood Pressure; Brain Chemistry; B	2005
Mechanisms for abnormal postprandial glucose metabolism in type 2 diabetes. American journal of physiology. Endocrinology and metabolism, 2006, Volume: 290, Issue:1 Topics: Alanine; Blood Glucose; Carbon Dioxide; Diabetes Mellitus, Type 2; Fatty Acids, Nonesterified; Femal	2006
Role of the hepatic sympathetic nerves in the regulation of net hepatic glucose uptake and the mediation of the portal glucose signal. American journal of physiology. Endocrinology and metabolism, 2006, Volume: 290, Issue:1 Topics: Animals; Blood Glucose; Dogs; Glucagon; Glucose; Glycerol; Hyperglycemia; Infusions, Intravenous; In	2006
Hyperglycemic response to hemorrhage is modulated by baroreceptors unloading but not by peripheral chemoreceptors activation. Autonomic neuroscience : basic & clinical, 2005, Dec-30, Volume: 123, Issue:1-2 Topics: Animals; Blood Glucose; Blood Pressure; Carotid Body; Chemoreceptor Cells; Cyanides; Heart Rate; Hem	2005
Monitoring metabolite gradients in the blood, liver, and tumor after induced hyperglycemia in rats with R3230 flank tumors using microdialysis and bioluminescence imaging. Advances in experimental medicine and biology, 2005, Volume: 566 Topics: Animals; Blood Glucose; Female; Glucose; Humans; Hyperglycemia; Lactic Acid; Liver; Luminescent Meas	2005
The effect of an acute elevation of NEFA concentrations on glucagon-stimulated hepatic glucose output. American journal of physiology. Endocrinology and metabolism, 2006, Volume: 291, Issue:3 Topics: 3-Hydroxybutyric Acid; Acetoacetates; Amino Acids; Animals; Blood Glucose; Cyclic AMP; Dogs; Fat Emu	2006
Suramin-induced reciprocal changes in glucose and lactate synthesis in renal tubules contribute to its hyperglycaemic action. European journal of pharmacology, 2006, May-10, Volume: 537, Issue:1-3 Topics: Animals; Cells, Cultured; Glucose; Glycolysis; Hepatocytes; Hyperglycemia; Kidney Tubules; Lactic Ac	2006
Reexamining the hyperglycemic pseudohypoxia hypothesis of diabetic oculopathy. Investigative ophthalmology & visual science, 2006, Volume: 47, Issue:6 Topics: Adenosine Triphosphate; Aldehyde Reductase; Animals; Cell Culture Techniques; Diabetes Mellitus, Exp	2006
Inhibition of fructose 1,6-bisphosphatase reduces excessive endogenous glucose production and attenuates hyperglycemia in Zucker diabetic fatty rats. Diabetes, 2006, Volume: 55, Issue:6 Topics: Alanine; Animals; Blood Glucose; Body Weight; Cholesterol; Diabetes Mellitus, Type 2; Eating; Female	2006
MCA Vmean and the arterial lactate-to-pyruvate ratio correlate during rhythmic handgrip. Journal of applied physiology (Bethesda, Md. : 1985), 2006, Volume: 101, Issue:5 Topics: Adult; Blood Flow Velocity; Blood Pressure; Brain; Cerebrovascular Circulation; Exercise; Glucose Cl	2006
Is blood sugar the next lactate? The American surgeon, 2006, Volume: 72, Issue:7 Topics: Adult; Age Factors; Bacterial Infections; Blood Glucose; Cause of Death; Craniocerebral Trauma; Crit	2006
Brain lactate responses during visual stimulation in fasting and hyperglycemic subjects: a proton magnetic resonance spectroscopy study at 1.5 Tesla. Psychiatry research, 2006, Nov-22, Volume: 148, Issue:1 Topics: Adult; Aspartic Acid; Blood Glucose; Brain; Choline; Creatine; Energy Metabolism; Fasting; Female; H	2006
The effect of vagal cooling on canine hepatic glucose metabolism in the presence of hyperglycemia of peripheral origin. Metabolism: clinical and experimental, 2007, Volume: 56, Issue:6 Topics: Animals; Blood Glucose; Cold Temperature; Dogs; Glucose; Hyperglycemia; Lactic Acid; Liver; Liver Ci	2007
Sensitivity to metabolic signals in late-gestation growth-restricted fetuses from rapidly growing adolescent sheep. American journal of physiology. Endocrinology and metabolism, 2007, Volume: 293, Issue:5 Topics: Adiposity; Animals; Body Weight; Female; Fetal Growth Retardation; Fetus; Glucose; Glucose Clamp Tec	2007
The effects of hyperglycemia on ischemic cell change and reactive neuronal change in neonatal rat brain following transient forebrain ischemia. Brain & development, 2008, Volume: 30, Issue:2 Topics: Animals; Animals, Newborn; Glucose; Hyperglycemia; Ischemic Attack, Transient; Lactic Acid; Neurons;	2008
Increased insulin sensitivity and maintenance of glucose utilization rates in fetal sheep with placental insufficiency and intrauterine growth restriction. American journal of physiology. Endocrinology and metabolism, 2007, Volume: 293, Issue:6 Topics: Animals; Blood Glucose; Cyclic AMP Response Element-Binding Protein; Female; Fetal Growth Retardatio	2007
Letter to the editor re: Richard J. Maddock et al. "Brain lactate responses during visual stimulation in fasting and hyperglycemic subjects: a proton magnetic resonance study at 1.5 T" [Psychiatry Research 2006; 148:47-54]. Psychiatry research, 2008, Feb-28, Volume: 162, Issue:2 Topics: Artifacts; Fasting; Humans; Hyperglycemia; Image Processing, Computer-Assisted; Lactic Acid; Magneti	2008
Impact of hyperglycemia on neurological deficits and extracellular glucose levels in aneurysmal subarachnoid hemorrhage patients. Neurological research, 2007, Volume: 29, Issue:7 Topics: Adult; Blood Glucose; Brain; Energy Metabolism; Extracellular Fluid; Female; Glucose; Glycolysis; Hu	2007
Hepatic portal venous delivery of a nitric oxide synthase inhibitor enhances net hepatic glucose uptake. American journal of physiology. Endocrinology and metabolism, 2008, Volume: 294, Issue:4 Topics: Animals; Blood Glucose; Carbon; Catheterization; Dogs; Dose-Response Relationship, Drug; Enzyme Inhi	2008
The actions of dichloroacetic acid on blood glucose, liver glycogen and fatty acid synthesis in obese-hyperglycaemic (ob/ob) and lean mice. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1983, Volume: 15, Issue:5 Topics: Acetates; Adipose Tissue; Animals; Blood Glucose; Dichloroacetic Acid; Fatty Acids; Female; Hypergly	1983
Mechanism of hyperglycemia and response to treatment with an inhibitor of fatty acid oxidation in a patient with insulin resistance due to antiinsulin receptor antibodies. The Journal of clinical endocrinology and metabolism, 1984, Volume: 59, Issue:4 Topics: Adipose Tissue; Alanine; Epoxy Compounds; Erythrocytes; Ethers, Cyclic; Fatty Acids, Nonesterified;	1984
Continuous noninvasive monitoring of pH and temperature in rat Walker 256 carcinoma during normoglycemia and hyperglycemia. Journal of the National Cancer Institute, 1984, Volume: 73, Issue:2 Topics: Animals; Blood Glucose; Blood Viscosity; Body Temperature; Carcinoma 256, Walker; Female; Glucose; H	1984
Endotoxin dose. II. Effects on glucose biokinetics in Yucatan minipigs. The American journal of physiology, 1983, Volume: 244, Issue:4 Topics: Animals; Blood Glucose; Endotoxins; Female; Hyperglycemia; Hypoglycemia; Kinetics; Lactates; Lactic	1983
Umbilical glucose and lactate extractions during maternal hyperglycemia in sheep. The American journal of physiology, 1983, Volume: 244, Issue:6 Topics: Animals; Blood Glucose; Female; Femoral Artery; Femoral Vein; Hyperglycemia; Kinetics; Lactates; Lac	1983
The effects of terbutaline on acid base, serum electrolytes, and glucose homeostasis during the management of preterm labor. American journal of obstetrics and gynecology, 1981, Nov-15, Volume: 141, Issue:6 Topics: Acid-Base Equilibrium; Blood Glucose; Female; Homeostasis; Humans; Hyperglycemia; Lactates; Lactic A	1981
Effects of lactate on glucose metabolism in healthy subjects and in severely injured hyperglycemic patients. The American journal of physiology, 1995, Volume: 268, Issue:4 Pt 1 Topics: Adolescent; Adult; Aged; Blood Glucose; Critical Illness; Energy Metabolism; Female; Glucose; Homeos	1995
Insulinopenia and hyperglycemia influence the in vivo partitioning of GE and SI. The American journal of physiology, 1995, Volume: 268, Issue:3 Pt 1 Topics: Animals; Blood Glucose; Dogs; Fatty Acids, Nonesterified; Glucagon; Glucose; Glucose Clamp Technique	1995
Effects of hypo- and hyperglycemia on brain energy metabolites in mice exposed to carbon monoxide. Toxicology letters, 1994, Volume: 73, Issue:2 Topics: Animals; Brain; Carbon Monoxide Poisoning; Energy Metabolism; Glucose; Hyperglycemia; Hypoglycemia;	1994
Pathogenesis of glucose intolerance and diabetes mellitus in cirrhosis. Hepatology (Baltimore, Md.), 1994, Volume: 19, Issue:3 Topics: Adult; Aged; Blood Glucose; C-Peptide; Diabetes Mellitus; Female; Glucose; Glucose Clamp Technique;	1994
Insulin-like growth factor-I and insulin have no differential effects on glucose production and utilization under conditions of hyperglycemia. Endocrinology, 1994, Volume: 134, Issue:5 Topics: Animals; Blood Glucose; Dogs; Fatty Acids, Nonesterified; Glucose; Glucose Clamp Technique; Glycerol	1994
The use of vitreous humor levels of glucose, lactic acid and blood levels of acetone to establish antemortem hyperglycemia in diabetics. Forensic science international, 1994, Volume: 65, Issue:1 Topics: Acetone; Adolescent; Adult; Aged; Aged, 80 and over; Autopsy; Child; Child, Preschool; Death, Sudden	1994
Demonstration of defective glucose uptake and storage in erythrocytes from non-insulin dependent diabetic patients and effects of metformin. Clinical and experimental pharmacology & physiology, 1993, Volume: 20, Issue:9 Topics: Adult; Diabetes Mellitus, Type 2; Erythrocytes; Glucose; Glycogen; Humans; Hyperglycemia; Lactates;	1993
Intra-ventromedial hypothalamic injection of cholinergic agents induces rapid hyperglycemia, hyperlactatemia and gluconeogenesis activation in fed, conscious rats. Brain research, 1993, Oct-29, Volume: 626, Issue:1-2 Topics: Adrenal Medulla; Animals; Carbachol; Food; Gluconeogenesis; Hyperglycemia; Hypothalamic Area, Latera	1993
Cerebral metabolism and electrocortical activity in the chronically hyperglycemic fetal lamb. The American journal of physiology, 1993, Volume: 265, Issue:6 Pt 2 Topics: Animals; Arteries; Blood Glucose; Brain; Cerebral Cortex; Chronic Disease; Electroencephalography; F	1993
Microregional distributions of glucose, lactate, ATP and tissue pH in experimental tumours upon local hyperthermia and/or hyperglycaemia. Journal of cancer research and clinical oncology, 1993, Volume: 119, Issue:10 Topics: Adenosine Triphosphate; Animals; Blood Glucose; Glucose; Hydrogen-Ion Concentration; Hyperglycemia;	1993
Uptake of glucose during continuous arteriovenous hemofiltration. Critical care medicine, 1993, Volume: 21, Issue:8 Topics: Acute Kidney Injury; Adolescent; Adult; Aged; Aged, 80 and over; Blood Glucose; Blood Urea Nitrogen;	1993
In vivo metabolic response of glucose to dichloroacetate in humans. The Journal of surgical research, 1996, Volume: 61, Issue:2 Topics: Adult; Alanine; Dichloroacetic Acid; Feedback; Glucose; Humans; Hyperglycemia; Lactates; Lactic Acid	1996
Intracellular lactate- and pyruvate-interconversion rates are increased in muscle tissue of non-insulin-dependent diabetic individuals. The Journal of clinical investigation, 1996, Jul-01, Volume: 98, Issue:1 Topics: Adult; Blood Glucose; Body Fluid Compartments; Diabetes Mellitus, Type 2; Forearm; Humans; Hyperglyc	1996
Effects of hyperinsulinemia and hyperglycemia on lactate release and local blood flow in subcutaneous adipose tissue of healthy humans. The Journal of clinical endocrinology and metabolism, 1996, Volume: 81, Issue:8 Topics: Adipose Tissue; Administration, Oral; Adult; Drinking; Glucose; Glucose Clamp Technique; Humans; Hyp	1996
The effect of hyperglycemia on cerebral metabolism during hypoxia-ischemia in the immature rat. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1996, Volume: 16, Issue:5 Topics: Adenosine Triphosphate; Animals; Body Water; Brain; Brain Ischemia; Carotid Arteries; Glucose; Glyco	1996
McArdle's disease with non-insulin-dependent diabetes mellitus: the beneficial effects of hyperglycemia and hyperinsulinemia for exercise intolerance. Internal medicine (Tokyo, Japan), 1996, Volume: 35, Issue:5 Topics: Biopsy; Blood Glucose; Cerebral Infarction; Creatine Kinase; Diabetes Mellitus, Type 2; Eating; Exer	1996
Role of the kidney in plasma glucose regulation during hyperglycemia. The American journal of physiology, 1997, Volume: 272, Issue:5 Pt 1 Topics: Animals; Arteries; Blood Glucose; Dogs; Glucose; Glycogen; Hyperglycemia; Kidney; Lactic Acid; Male;	1997
Glucose-lowering effect of BTS 67 582. British journal of pharmacology, 1997, Volume: 122, Issue:7 Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 1; Glucose Tolerance Test; Guanidines; Hyperglycemia	1997
Imprinting of female offspring with testosterone results in insulin resistance and changes in body fat distribution at adult age in rats. The Journal of clinical investigation, 1998, Jan-01, Volume: 101, Issue:1 Topics: Adipose Tissue; Adrenocorticotropic Hormone; Animals; Blood Glucose; Corticosterone; Fatty Acids, No	1998
Overexpression of glyoxalase-I in bovine endothelial cells inhibits intracellular advanced glycation endproduct formation and prevents hyperglycemia-induced increases in macromolecular endocytosis. The Journal of clinical investigation, 1998, Mar-01, Volume: 101, Issue:5 Topics: Acetone; Aldehydes; Animals; Cattle; Endocytosis; Endothelium, Vascular; Gene Expression Regulation,	1998
Hormonal counterregulation failure in rats is related to previous hyperglycaemia-hyperinsulinaemia. Diabetes & metabolism, 1998, Volume: 24, Issue:1 Topics: Animals; Blood Glucose; Body Weight; Catecholamines; Eating; Female; Glucagon; Glycerol; Hyperglycem	1998
Effect of hyperglycemia on pyruvate dehydrogenase activity and energy metabolites during ischemia and reperfusion in gerbil brain. Brain research, 1998, Mar-30, Volume: 788, Issue:1-2 Topics: Adenosine Triphosphate; Animals; Cerebral Cortex; Energy Metabolism; Gerbillinae; Hyperglycemia; Isc	1998
Hyperglycemia increases neurological damage and behavioral deficits from post-traumatic secondary ischemic insults. Journal of neurotrauma, 1998, Volume: 15, Issue:5 Topics: Animals; Behavior, Animal; Blood Gas Analysis; Blood Glucose; Blood Pressure; Body Temperature; Body	1998
Effect of induced hyperglycemia on brain cell membrane function and energy metabolism during the early phase of experimental meningitis in newborn piglets. Brain research, 1998, Jul-06, Volume: 798, Issue:1-2 Topics: Animals; Animals, Newborn; Blood Glucose; Brain; Cell Membrane; Colony Count, Microbial; Energy Meta	1998
Effect of hyperglycemia on brain cell membrane function and energy metabolism during hypoxia-ischemia in newborn piglets. Brain research, 1998, Jul-06, Volume: 798, Issue:1-2 Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Brain; Brain Ischemia; Cell Membrane; Energy Meta	1998
Glucose production, utilization, and cycling in response to moderate exercise in obese subjects with type 2 diabetes and mild hyperglycemia. Diabetes, 1998, Volume: 47, Issue:11 Topics: Adult; Alanine; Blood Glucose; C-Peptide; Diabetes Mellitus; Diabetes Mellitus, Type 2; Exercise; Fe	1998
Role of alpha2-adrenoceptors on the hyperglycaemic and insulin secretory effects derived from alpha1- and beta-adrenoceptor stimulation in the rabbit. Journal of autonomic pharmacology, 1998, Volume: 18, Issue:5 Topics: Adrenergic alpha-Agonists; Albuterol; Animals; Blood Glucose; Blood Pressure; Brimonidine Tartrate;	1998
Lactate metabolism of subcutaneous adipose tissue studied by open flow microperfusion. The Journal of clinical endocrinology and metabolism, 1998, Volume: 83, Issue:12 Topics: Adipose Tissue; Adult; Glucose Clamp Technique; Humans; Hyperglycemia; Hyperinsulinism; Lactic Acid;	1998
Hormonal and metabolic responses to maintained hyperglycemia during prolonged exercise. Journal of applied physiology (Bethesda, Md. : 1985), 1999, Volume: 87, Issue:1 Topics: 3-Hydroxybutyric Acid; Adult; Blood Glucose; Epinephrine; Exercise; Exercise Test; Fatty Acids, None	1999
Effects of blood sugar level on rat transient focal brain ischemia consecutively observed by diffusion-weighted EPI and (1)H echo planar spectroscopic imaging. Magnetic resonance in medicine, 1999, Volume: 42, Issue:5 Topics: Animals; Blood Glucose; Brain; Cerebrovascular Circulation; Echo-Planar Imaging; Glucose; Hyperglyce	1999
Ethnicity affects the postprandial regulation of glycogenolysis. The American journal of physiology, 1999, Volume: 277, Issue:5 Topics: Adult; Asian People; Blood Glucose; Carbon Isotopes; Diabetes Mellitus, Type 2; Energy Metabolism; G	1999
The effect of topical insulin on the release of excitotoxic and other amino acids from the rat cerebral cortex during streptozotocin-induced hyperglycemic ischemia. Brain research, 2000, Jul-28, Volume: 872, Issue:1-2 Topics: Administration, Topical; Animals; Aspartic Acid; Blood Glucose; Brain Ischemia; Cerebral Cortex; Dia	2000
Regulation of uterine and umbilical amino acid uptakes by maternal amino acid concentrations. American journal of physiology. Regulatory, integrative and comparative physiology, 2000, Volume: 279, Issue:3 Topics: Amino Acids; Animals; Blood Glucose; Female; Gestational Age; Glucose Clamp Technique; Hyperglycemia	2000
Correction of hyperglycemia and insulin sensitivity by T-1095, an inhibitor of renal Na+-glucose cotransporters, in streptozotocin-induced diabetic rats. Japanese journal of pharmacology, 2000, Volume: 84, Issue:3 Topics: Animals; Carbonates; Deoxyglucose; Diabetes Mellitus, Experimental; Glucosides; Hyperglycemia; Hypog	2000
Effects of cardiogenic shock on lactate and glucose metabolism after heart surgery. Critical care medicine, 2000, Volume: 28, Issue:12 Topics: Acidosis, Lactic; Adult; Aged; Bilirubin; Cardiac Surgical Procedures; Case-Control Studies; Female;	2000
Centrally injected atropine reduces hyperglycemia caused by 2-DG or immobilization stress in awake rats. Physiology & behavior, 2001, Volume: 72, Issue:1-2 Topics: Animals; Antimetabolites; Atropine; Blood Glucose; Deoxyglucose; Hyperglycemia; Immobilization; Inje	2001
Peritoneal dialysis in an infant with type 1 diabetes and hyperosmolar coma. Journal of endocrinological investigation, 2001, Volume: 24, Issue:2 Topics: Acidosis, Lactic; Dehydration; Diabetes Mellitus, Type 1; Female; Follow-Up Studies; Humans; Hypergl	2001
Alpha- and beta-cell responses to small changes in plasma glucose in the conscious dog. Diabetes, 2001, Volume: 50, Issue:2 Topics: Alanine; Animals; Arteries; Blood Glucose; Dogs; Female; Gluconeogenesis; Glucose; Glycerol; Glycoge	2001
Suppression of the accumulation of triosephosphates and increased formation of methylglyoxal in human red blood cells during hyperglycaemia by thiamine in vitro. Journal of biochemistry, 2001, Volume: 129, Issue:4 Topics: Deoxyglucose; Diabetes Complications; Diabetes Mellitus; Erythrocytes; Glucose; Glycolysis; Humans;	2001
Energy fuel utilization by fetal versus young rabbit brain: a 13C MRS isotopomer analysis of [U-(13)C]glucose metabolites. Brain research, 2001, Mar-30, Volume: 896, Issue:1-2 Topics: 3-Hydroxybutyric Acid; Age Factors; Amino Acids; Animals; Astrocytes; Brain; Carbon Isotopes; Energy	2001
Inhibitory effect of hyperglycemia on insulin-induced Akt/protein kinase B activation in skeletal muscle. American journal of physiology. Endocrinology and metabolism, 2001, Volume: 280, Issue:5 Topics: Animals; Biological Transport; Deoxyglucose; Diabetes Mellitus, Experimental; Enzyme Activation; Glu	2001
Effects of hyperglycemia or hypoglycemia on brain cell membrane function and energy metabolism during the immediate reoxygenation-reperfusion period after acute transient global hypoxia-ischemia in the newborn piglet. Brain research, 2001, May-18, Volume: 901, Issue:1-2 Topics: Adenosine Triphosphatases; Animals; Animals, Newborn; Asphyxia Neonatorum; Blood Gas Analysis; Blood	2001
Metabolic effects of metaproterenol overdose: hypokalemia, hyperglycemia and hyperlactatemia. Veterinary and human toxicology, 2001, Volume: 43, Issue:3 Topics: Adolescent; Adrenergic beta-Agonists; Bronchodilator Agents; Drug Overdose; Female; Humans; Hypergly	2001
Enhancement of hyperglycemia-induced acidification of human melanoma xenografts with inhibitors of respiration and ion transport. Academic radiology, 2001, Volume: 8, Issue:7 Topics: 3-Iodobenzylguanidine; Animals; Cell Respiration; Coumaric Acids; Glycolysis; Humans; Hydrogen-Ion C	2001
[Novel methods in diabetes mellitus diagnosis]. Klinicheskaia laboratornaia diagnostika, 2001, Issue:8 Topics: Cadaver; Coma; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Glucose; Humans; Hyperglycemia;	2001
Preischemic hyperglycemia-aggravated damage: evidence that lactate utilization is beneficial and glucose-induced corticosterone release is detrimental. Journal of neuroscience research, 2001, Dec-01, Volume: 66, Issue:5 Topics: Adenosine Diphosphate; Adenosine Monophosphate; Animals; Blood Glucose; Brain Ischemia; Corticostero	2001
Short-term mild hyperglycemia enhances insulin-stimulated glucose disposal in lactating goats. American journal of physiology. Regulatory, integrative and comparative physiology, 2002, Volume: 282, Issue:2 Topics: Amino Acids; Animals; Blood Glucose; Eating; Female; Glucose; Glucose Transporter Type 4; Goats; Hyp	2002
Inclusion of low amounts of fructose with an intraduodenal glucose load markedly reduces postprandial hyperglycemia and hyperinsulinemia in the conscious dog. Diabetes, 2002, Volume: 51, Issue:2 Topics: Alanine; Animals; Blood Glucose; Dogs; Duodenum; Fructose; Glucagon; Gluconeogenesis; Glucose; Glyce	2002
Glucose kinetics and splanchnic uptake following mixed meal ingestion in cirrhotic-diabetic subjects. Diabetes, nutrition & metabolism, 2001, Volume: 14, Issue:6 Topics: Adult; Blood Glucose; Diabetes Complications; Diabetes Mellitus; Dietary Carbohydrates; Fatty Acids,	2001
Lactic acidosis following heart transplantation: a common phenomenon? European journal of heart failure, 2002, Volume: 4, Issue:2 Topics: Acidosis, Lactic; Adolescent; Adrenergic beta-Agonists; Adult; Cardiotonic Agents; Combined Modality	2002
Effects of propofol on lactate accumulation and oedema formation in focal cerebral ischaemia in hyperglycaemic rats. British journal of anaesthesia, 2002, Volume: 88, Issue:3 Topics: Anesthetics, Intravenous; Animals; Brain; Brain Edema; Brain Ischemia; Hyperglycemia; Lactic Acid; M	2002
The effect of hyperglycemia on acid-base and sympathoadrenal responses in the hypoxemic fetal monkey. Journal of developmental physiology, 1992, Volume: 17, Issue:6 Topics: Acid-Base Equilibrium; Adrenal Glands; Animals; Blood Glucose; Blood Pressure; Carbon Dioxide; Catec	1992
Importance of peripheral insulin levels for insulin-induced suppression of glucose production in depancreatized dogs. The Journal of clinical investigation, 1992, Volume: 90, Issue:5 Topics: Animals; Dogs; Fatty Acids, Nonesterified; Glucagon; Gluconeogenesis; Glucose; Hyperglycemia; Insuli	1992
Effects of hyperglycemia on the time course of changes in energy metabolism and pH during global cerebral ischemia and reperfusion in rats: correlation of 1H and 31P NMR spectroscopy with fatty acid and excitatory amino acid levels. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1992, Volume: 12, Issue:3 Topics: Acidosis, Lactic; Animals; Aspartic Acid; Brain Chemistry; Brain Ischemia; Energy Metabolism; Fatty	1992
Hyperglycemia and the rate of lactic acid accumulation during cerebral ischemia in developing animals: in vivo proton MRS study. Biology of the neonate, 1992, Volume: 61, Issue:4 Topics: Aging; Animals; Animals, Newborn; Blood Glucose; Brain; Dogs; Hyperglycemia; Ischemic Attack, Transi	1992
Twenty-four hour fasting increases endotoxin lethality in the rat. The European journal of surgery = Acta chirurgica, 1991, Volume: 157, Issue:2 Topics: Animals; Endotoxins; Fasting; Hyperglycemia; Lactates; Lactic Acid; Liver Glycogen; Male; Rats; Rats	1991
Focal and perifocal changes in tissue energy state during middle cerebral artery occlusion in normo- and hyperglycemic rats. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1992, Volume: 12, Issue:1 Topics: Adenine Nucleotides; Animals; Arterial Occlusive Diseases; Blood Pressure; Body Temperature; Brain;	1992
Hemorrhagic infarct conversion in experimental stroke. Annals of emergency medicine, 1992, Volume: 21, Issue:2 Topics: Adenosine Triphosphate; Animals; Brain; Brain Chemistry; Brain Ischemia; Cats; Cerebral Arteries; Ce	1992
The effect of age on glucose-modulated cerebral agonal glycolytic rates measured in vivo by 1H NMR spectroscopy. Pediatric research, 1991, Volume: 30, Issue:6 Topics: Age Factors; Animals; Animals, Newborn; Blood Glucose; Brain; Brain Injuries; Brain Ischemia; Glycol	1991
Effect of hypoxia on cerebral metabolites measured by proton nuclear magnetic resonance spectroscopy in rats. Stroke, 1991, Volume: 22, Issue:1 Topics: Animals; Aspartic Acid; Brain; Hyperglycemia; Hypoglycemia; Hypoxia; Lactates; Lactic Acid; Magnetic	1991
Extracellular pH in the brain during ischemia: relationship to the severity of lactic acidosis. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1991, Volume: 11, Issue:4 Topics: Acidosis, Lactic; Animals; Brain; Carbon Dioxide; Hydrogen-Ion Concentration; Hyperglycemia; Ischemi	1991
Acute changes of systemic parameters in tumour-bearing rats, and of tumour glucose, lactate, and ATP levels upon local hyperthermia and/or hyperglycaemia. Journal of cancer research and clinical oncology, 1991, Volume: 117, Issue:5 Topics: Adenosine Triphosphate; Animals; Blood Glucose; Blood Pressure; Carbon Dioxide; Combined Modality Th	1991
Carbohydrate metabolism during intense exercise when hyperglycemic. Journal of applied physiology (Bethesda, Md. : 1985), 1991, Volume: 70, Issue:2 Topics: Blood Glucose; Carbohydrate Metabolism; Exercise; Fatty Acids, Nonesterified; Glucose; Glycogen; Hum	1991
[Effect of biguanides on the indicators of thrombelastography and the level of lactic acid in diabetes mellitus]. Sovetskaia meditsina, 1990, Issue:12 Topics: Adolescent; Adult; Aged; Biguanides; Blood Coagulation; Diabetes Mellitus, Type 1; Diabetes Mellitus	1990
Hyperglycemic effect of prolactin in anterior pituitary transplanted rats. Endocrinologia japonica, 1990, Volume: 37, Issue:6 Topics: Animals; Female; Hyperglycemia; Lactates; Lactic Acid; Pituitary Gland; Pituitary Gland, Anterior; P	1990
Elevated serum lactate following hyperventilation during glucose infusion in panic disorder. Biological psychiatry, 1990, Feb-15, Volume: 27, Issue:4 Topics: Adult; Alkalosis, Respiratory; Anxiety Disorders; Fear; Female; Glucose; Humans; Hyperglycemia; Hype	1990
Does fetal acidosis develop with maternal glucose infusion during normal labor? Obstetrics and gynecology, 1989, Volume: 74, Issue:6 Topics: Acidosis; Adult; Female; Fetal Diseases; Fetal Distress; Glucose; Humans; Hyperglycemia; Isotonic So	1989
Differential effects of insulin and hyperglycemia on intracellular glucose disposition in humans. Metabolism: clinical and experimental, 1989, Volume: 38, Issue:5 Topics: Adult; Female; Glucose; Humans; Hyperglycemia; Insulin; Intracellular Membranes; Lactates; Lactic Ac	1989
Preservation of pancreatic beta cell function with pulsatile cardiopulmonary bypass. The Annals of thoracic surgery, 1989, Volume: 48, Issue:6 Topics: Blood Glucose; C-Peptide; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Female; Glucagon; Hum	1989
Direct evidence for a stimulatory effect of hyperglycemia per se on peripheral glucose disposal in type II diabetes. The Journal of clinical investigation, 1986, Volume: 77, Issue:4 Topics: 3-Hydroxybutyric Acid; Adult; Alanine; C-Peptide; Diabetes Mellitus, Type 2; Female; Hemoglobin A; H	1986
Modification of the glyoxalase system in human red blood cells by glucose in vitro. The Biochemical journal, 1988, Sep-15, Volume: 254, Issue:3 Topics: Erythrocytes; Glucose; Glutathione; Humans; Hyperglycemia; In Vitro Techniques; Lactates; Lactic Aci	1988
[Postaggression metabolism following laparotomy and thoracotomy]. Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 1988, Volume: 59, Issue:1 Topics: Abdominal Neoplasms; Adult; Aged; Aged, 80 and over; Amino Acids; Ammonia; Blood Glucose; Fatty Acid	1988
Cerebral metabolic responses of hyperglycemic immature rats to hypoxia-ischemia. Pediatric research, 1987, Volume: 21, Issue:6 Topics: Adenine Nucleotides; Animals; Animals, Newborn; Blood Glucose; Brain; Brain Ischemia; Glucose; Hyper	1987
Hyperglycemia, cerebrospinal fluid lactic acidosis, and cerebral blood flow in severely head-injured patients. Neurosurgery, 1987, Volume: 21, Issue:1 Topics: Acidosis; Adult; Blood Glucose; Brain; Brain Injuries; Cerebrovascular Circulation; Coma; Humans; Hy	1987
Changes in cerebral glycogenolysis and related enzymes in diazinon treated hyperglycaemic animals. Journal of applied toxicology : JAT, 1987, Volume: 7, Issue:2 Topics: Animals; Blood Glucose; Brain; Brain Chemistry; Cholinesterases; Diazinon; Female; Glycogen; Hypergl	1987
Lactate production in type B hyperlactataemia due to infective encephalopathy. Annals of the Academy of Medicine, Singapore, 1986, Volume: 15, Issue:1 Topics: Blood Glucose; Child; Child, Preschool; Encephalitis; Fatty Acids, Nonesterified; Glucose; Humans; H	1986
Changes in extra- and intracellular pH in the brain during and following ischemia in hyperglycemic and in moderately hypoglycemic rats. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1986, Volume: 6, Issue:5 Topics: Acidosis; Animals; Brain; Extracellular Space; Hydrogen-Ion Concentration; Hyperglycemia; Hypoglycem	1986
Hyperglycemia does not augment neuronal damage in experimental status epilepticus. Neurology, 1986, Volume: 36, Issue:10 Topics: Animals; Brain; Glucose; Hyperglycemia; Lactates; Lactic Acid; Male; Neurons; Rats; Rats, Inbred Str	1986
[The effect of hyperglycemia on ischemic brain damage: relevance to the local cerebral blood flow]. No to shinkei = Brain and nerve, 1986, Volume: 38, Issue:12 Topics: Animals; Autoradiography; Blood Glucose; Brain; Brain Ischemia; Hyperglycemia; Lactates; Lactic Acid	1986
Consequences of perturbations of fetal fuels in ovine pregnancy. Diabetes, 1985, Volume: 34 Suppl 2 Topics: Animals; Blood Glucose; Disease Models, Animal; Female; Fetal Blood; Fetal Hypoxia; Fetus; Glucose;	1985

lactic acid and Hyperglycemia, Postprandial