lactic acid has been researched along with Hyperammonemia in 26 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Hyperammonemia: Elevated level of AMMONIA in the blood. It is a sign of defective CATABOLISM of AMINO ACIDS or ammonia to UREA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study was to investigate the effects of ammonia and manganese in the metabolism of minimal hepatic encephalopathy (MHE)." | 8.31 | The interaction of ammonia and manganese in abnormal metabolism of minimal hepatic encephalopathy: A comparison metabolomics study. ( Li, Y; Liu, XF; Lu, JJ; Qiang, JW; Yang, XY, 2023) |
| "Hyperornithinemia, hyperammonemia, and homocitrullinuria (HHH) syndrome is caused by mutations in the SLC25A15 (ORNT1) gene encoding the mitochondrial ornithine transporter, but the mechanism of pathogenesis of the encephalopathy, spastic paraparesis and hepatopathy remains undetermined." | 7.72 | Hyperornithinemia, hyperammonemia, and homocitrullinuria syndrome with evidence of mitochondrial dysfunction due to a novel SLC25A15 (ORNT1) gene mutation in a Palestinian family. ( Abu-Libdeh, B; Gutman, A; Kanazawa, N; Korman, SH; Tsujino, S, 2004) |
| "A random retrospective chart review was conducted to document serum carnitine levels on 100 children with autism." | 7.72 | Relative carnitine deficiency in autism. ( Cummings, C; Filipek, PA; Gargus, JJ; Juranek, J; Nguyen, MT, 2004) |
| "Hyperammonemia is a consistent finding in many metabolic disorders." | 5.31 | The effect of ammonium chloride on metabolism of primary neurons and neuroblastoma cells in vitro. ( Geraminegad, P; Haghighat, N; McCandless, DW, 2000) |
| "This study was to investigate the effects of ammonia and manganese in the metabolism of minimal hepatic encephalopathy (MHE)." | 4.31 | The interaction of ammonia and manganese in abnormal metabolism of minimal hepatic encephalopathy: A comparison metabolomics study. ( Li, Y; Liu, XF; Lu, JJ; Qiang, JW; Yang, XY, 2023) |
| " Cyclophosphamide caused hyperammonemia; glutamine/ammonia and urea/ammonia ratios in the blood decreased." | 3.78 | Aggravation of cyclophosphamide-induced acute neurological disorders under conditions of artificial acidification of chyme in rats. ( Ivnitsky, JJ; Malakhovsky, VN; Rejuniuk, VL; Schaefer, TV, 2012) |
| "Hyperammonemia causes brain edema and high intracranial pressure (ICP) in acute liver failure (ALF) by accumulation of glutamine in brain." | 3.74 | Cerebral glutamine concentration and lactate-pyruvate ratio in patients with acute liver failure. ( Bjerring, PN; Frederiksen, HJ; Hansen, BA; Hauerberg, J; Jorgensen, L; Larsen, FS; Tofteng, F, 2008) |
| "Hyperornithinemia, hyperammonemia, and homocitrullinuria (HHH) syndrome is caused by mutations in the SLC25A15 (ORNT1) gene encoding the mitochondrial ornithine transporter, but the mechanism of pathogenesis of the encephalopathy, spastic paraparesis and hepatopathy remains undetermined." | 3.72 | Hyperornithinemia, hyperammonemia, and homocitrullinuria syndrome with evidence of mitochondrial dysfunction due to a novel SLC25A15 (ORNT1) gene mutation in a Palestinian family. ( Abu-Libdeh, B; Gutman, A; Kanazawa, N; Korman, SH; Tsujino, S, 2004) |
| "A random retrospective chart review was conducted to document serum carnitine levels on 100 children with autism." | 3.72 | Relative carnitine deficiency in autism. ( Cummings, C; Filipek, PA; Gargus, JJ; Juranek, J; Nguyen, MT, 2004) |
| "In patients with acute liver failure cerebral microdialysis studies show a linear correlation between the lactate to pyruvate ratio and the glutamine concentration, as well as to some of the adenosine triphosphate degradation products." | 2.49 | Changes in cerebral oxidative metabolism in patients with acute liver failure. ( Bjerring, PN; Larsen, FS, 2013) |
| " In a separate dose-response experiment cortex from healthy rats was incubated for 120 min in ammonium acetate in concentrations up to 80 mM prior to respirometry." | 1.46 | Accumulation of lactate in the rat brain during hyperammonaemia is not associated with impaired mitochondrial respiratory capacity. ( Bjerring, PN; Larsen, FS; Witt, AM, 2017) |
| "Patients with acute liver failure have a disturbed amino acid metabolism and a compromised oxidative metabolism in the brain." | 1.38 | The effect of fractionated plasma separation and adsorption on cerebral amino acid metabolism and oxidative metabolism during acute liver failure. ( Bjerring, PN; Clemmesen, JO; Frederiksen, HJ; Hauerberg, J; Larsen, FS; Nielsen, HB, 2012) |
| "The pathogenesis of cerebral edema in acute liver failure is suggested, in in vitro and animal studies, to involve a compromised oxidative metabolism with a decrease in cerebral ATP levels and an increase in purine concentrations." | 1.36 | Brain hypoxanthine concentration correlates to lactate/pyruvate ratio but not intracranial pressure in patients with acute liver failure. ( Bjerring, PN; Frederiksen, HJ; Hansen, BA; Hauerberg, J; Jørgensen, L; Larsen, FS; Tofteng, F, 2010) |
| "Hyperammonemia is a consistent finding in many metabolic disorders." | 1.31 | The effect of ammonium chloride on metabolism of primary neurons and neuroblastoma cells in vitro. ( Geraminegad, P; Haghighat, N; McCandless, DW, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (30.77) | 29.6817 |
| 2010's | 17 (65.38) | 24.3611 |
| 2020's | 1 (3.85) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, XF | 1 |
| Lu, JJ | 1 |
| Li, Y | 1 |
| Yang, XY | 1 |
| Qiang, JW | 1 |
| Wongkittichote, P | 1 |
| Ah Mew, N | 1 |
| Chapman, KA | 1 |
| Zielonka, M | 1 |
| Probst, J | 1 |
| Carl, M | 1 |
| Hoffmann, GF | 1 |
| Kölker, S | 1 |
| Okun, JG | 1 |
| Raturi, S | 1 |
| Venkatesh, IH | 1 |
| Nagesh, NK | 1 |
| Venkatagiri, P | 1 |
| Mehrotra, A | 1 |
| Trigun, SK | 1 |
| Camerino, SR | 1 |
| Lima, RC | 1 |
| França, TC | 1 |
| Herculano, Ede A | 1 |
| Rodrigues, DS | 1 |
| Gouveia, MG | 1 |
| Cameron, LC | 3 |
| Prado, ES | 3 |
| Diez-Fernandez, C | 1 |
| Rüfenacht, V | 1 |
| Santra, S | 1 |
| Lund, AM | 1 |
| Santer, R | 1 |
| Lindner, M | 1 |
| Tangeraas, T | 1 |
| Unsinn, C | 1 |
| de Lonlay, P | 1 |
| Burlina, A | 1 |
| van Karnebeek, CD | 1 |
| Häberle, J | 1 |
| Hertz, L | 2 |
| Song, D | 1 |
| Peng, L | 1 |
| Chen, Y | 1 |
| Witt, AM | 1 |
| Larsen, FS | 5 |
| Bjerring, PN | 5 |
| Andersson, AK | 1 |
| Adermark, L | 1 |
| Persson, M | 1 |
| Westerlund, A | 1 |
| Olsson, T | 1 |
| Hansson, E | 1 |
| de Almeida, RD | 2 |
| Llosa, CD | 1 |
| Magalhães-Neto, A | 1 |
| Hauerberg, J | 3 |
| Jørgensen, L | 1 |
| Frederiksen, HJ | 3 |
| Tofteng, F | 2 |
| Hansen, BA | 2 |
| de Rezende Neto, JM | 1 |
| Dória de Melo, MG | 1 |
| Joardar, S | 1 |
| Das, S | 1 |
| Chatterjee, R | 1 |
| Guha, G | 1 |
| Hasmi, MA | 1 |
| Nielsen, HB | 1 |
| Clemmesen, JO | 1 |
| Medeiros, WM | 1 |
| Carvalho, AC | 1 |
| Peres, P | 1 |
| De Luca, FA | 1 |
| Gun, C | 1 |
| Yoon, YA | 1 |
| Lee, DH | 1 |
| Ki, CS | 1 |
| Lee, SY | 1 |
| Kim, JW | 1 |
| Lee, YW | 1 |
| Park, HD | 1 |
| Schaefer, TV | 1 |
| Rejuniuk, VL | 1 |
| Malakhovsky, VN | 1 |
| Ivnitsky, JJ | 1 |
| García, MV | 1 |
| López-Mediavilla, C | 1 |
| Juanes de la Peña, MC | 1 |
| Medina, JM | 1 |
| Korman, SH | 1 |
| Kanazawa, N | 1 |
| Abu-Libdeh, B | 1 |
| Gutman, A | 1 |
| Tsujino, S | 1 |
| Filipek, PA | 1 |
| Juranek, J | 1 |
| Nguyen, MT | 1 |
| Cummings, C | 1 |
| Gargus, JJ | 1 |
| Kala, G | 1 |
| Hiroyama, M | 1 |
| Aoyagi, T | 1 |
| Fujiwara, Y | 1 |
| Oshikawa, S | 1 |
| Sanbe, A | 1 |
| Endo, F | 1 |
| Tanoue, A | 1 |
| Jorgensen, L | 1 |
| Haghighat, N | 1 |
| McCandless, DW | 1 |
| Geraminegad, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Cerebral Microdialysis in Patients With Fulminant Hepatic Failure[NCT00836420] | 50 participants (Actual) | Observational | 2000-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for lactic acid and Hyperammonemia
| Article | Year |
|---|---|
Propionyl-CoA carboxylase - A review.
Topics: Carbon-Carbon Ligases; Humans; Hyperammonemia; Lactic Acid; Methylmalonyl-CoA Decarboxylase; Mutatio | 2017 |
Multifactorial Effects on Different Types of Brain Cells Contribute to Ammonia Toxicity.
Topics: Ammonia; Animals; Astrocytes; Brain; Cyclic GMP; Energy Metabolism; Glutamine; Hepatic Encephalopath | 2017 |
Changes in cerebral oxidative metabolism in patients with acute liver failure.
Topics: Amino Acids; Ammonia; Animals; Brain; Brain Chemistry; Humans; Hyperammonemia; Lactic Acid; Liver Fa | 2013 |
3 trials available for lactic acid and Hyperammonemia
| Article | Year |
|---|---|
Keto analogue and amino acid supplementation and its effects on ammonemia and performance under thermoneutral conditions.
Topics: Amino Acids; Athletes; Athletic Performance; Bicycling; Body Weight; Cognition; Dietary Supplements; | 2016 |
Keto analogue and amino acid supplementation affects the ammonaemia response during exercise under ketogenic conditions.
Topics: Adult; Amino Acids; Analysis of Variance; Area Under Curve; Athletes; Blood Glucose; Case-Control St | 2011 |
The dysfunction of ammonia in heart failure increases with an increase in the intensity of resistance exercise, even with the use of appropriate drug therapy.
Topics: Adult; Ammonia; Biomarkers; Brazil; Cardiovascular Agents; Cross-Over Studies; Heart Failure; Humans | 2014 |
20 other studies available for lactic acid and Hyperammonemia
| Article | Year |
|---|---|
The interaction of ammonia and manganese in abnormal metabolism of minimal hepatic encephalopathy: A comparison metabolomics study.
Topics: Alanine; Ammonia; Animals; Arginine; Brain; Citrulline; gamma-Aminobutyric Acid; Glutamic Acid; Glut | 2023 |
Bioenergetic dysfunction in a zebrafish model of acute hyperammonemic decompensation.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Amino Acids, Branched-Chain; Animals; Brain Chemistry | 2019 |
Use of continuous hemodiafiltration for the treatment of a neonate with hyperammonemia secondary to argininosuccinate lyase (ASAL) deficiency.
Topics: Ammonia; Arginine; Argininosuccinate Lyase; Argininosuccinic Aciduria; Breast Feeding; Combined Moda | 2013 |
Moderate grade hyperammonemia activates lactate dehydrogenase-4 and 6-phosphofructo-2-kinase to support increased lactate turnover in the brain slices.
Topics: Ammonia; Animals; Brain; Enzyme Activation; Female; Hyperammonemia; Isoenzymes; L-Lactate Dehydrogen | 2013 |
Defective hepatic bicarbonate production due to carbonic anhydrase VA deficiency leads to early-onset life-threatening metabolic crisis.
Topics: Acidosis; Adolescent; Bicarbonates; Carbonic Anhydrases; Child; Child, Preschool; Humans; Hyperammon | 2016 |
Accumulation of lactate in the rat brain during hyperammonaemia is not associated with impaired mitochondrial respiratory capacity.
Topics: Animals; Biosensing Techniques; Brain Chemistry; Cerebral Cortex; Citric Acid Cycle; Encephalitis; H | 2017 |
Lactate contributes to ammonia-mediated astroglial dysfunction during hyperammonemia.
Topics: Actin Cytoskeleton; Ammonia; Ammonium Chloride; Animals; Astrocytes; Calcium; Cell Size; Cells, Cult | 2009 |
Acute supplementation with keto analogues and amino acids in rats during resistance exercise.
Topics: Amino Acids; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Diet; Dietary Supplem | 2010 |
Brain hypoxanthine concentration correlates to lactate/pyruvate ratio but not intracranial pressure in patients with acute liver failure.
Topics: Adolescent; Adult; Brain; Brain Edema; Female; Humans; Hyperammonemia; Hypoxanthine; Inosine; Intrac | 2010 |
Unilateral basal-ganglia involvement likely due to valproate-induced hyperammonemic encephalopathy.
Topics: Anticonvulsants; Basal Ganglia; Brain Diseases; Child, Preschool; Diffusion Magnetic Resonance Imagi | 2012 |
The effect of fractionated plasma separation and adsorption on cerebral amino acid metabolism and oxidative metabolism during acute liver failure.
Topics: Adult; Amino Acids; Cerebrum; Dialysis Solutions; Extracorporeal Circulation; Female; Glutamine; Hep | 2012 |
SLC22A5 mutations in a patient with systemic primary carnitine deficiency: the first Korean case confirmed by biochemical and molecular investigation.
Topics: Ammonia; Base Sequence; Cardiomyopathies; Carnitine; Humans; Hyperammonemia; Infant, Newborn; Lactic | 2012 |
Aggravation of cyclophosphamide-induced acute neurological disorders under conditions of artificial acidification of chyme in rats.
Topics: Acute Disease; Administration, Oral; Ammonia; Animals; Boric Acids; Cyclophosphamide; Gastric Juice; | 2012 |
Tolerance of neonatal rat brain to acute hyperammonemia.
Topics: Acute Disease; Adenosine Triphosphate; Age Factors; Ammonia; Animals; Animals, Newborn; Brain; Femal | 2003 |
Hyperornithinemia, hyperammonemia, and homocitrullinuria syndrome with evidence of mitochondrial dysfunction due to a novel SLC25A15 (ORNT1) gene mutation in a Palestinian family.
Topics: Adolescent; Alanine; Amino Acid Metabolism, Inborn Errors; Amino Acid Transport Systems, Basic; Arab | 2004 |
Relative carnitine deficiency in autism.
Topics: Adolescent; Alanine; Autistic Disorder; Carnitine; Child; Child, Preschool; Diagnostic and Statistic | 2004 |
Ammonia effects on pyruvate/lactate production in astrocytes--interaction with glutamate.
Topics: Ammonia; Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Bucladesine; Cells, Cultured; Cerebra | 2005 |
Hyperammonaemia in V1a vasopressin receptor knockout mice caused by the promoted proteolysis and reduced intrahepatic blood volume.
Topics: Amino Acids; Ammonia; Ammonium Chloride; Animals; Arginine Vasopressin; Blood Glucose; Blood Volume; | 2007 |
Cerebral glutamine concentration and lactate-pyruvate ratio in patients with acute liver failure.
Topics: Adolescent; Adult; Aged; Astrocytes; Brain; Brain Edema; Critical Care; Female; Glutamine; Humans; H | 2008 |
The effect of ammonium chloride on metabolism of primary neurons and neuroblastoma cells in vitro.
Topics: Adenosine Triphosphate; Ammonium Chloride; Animals; Brain; Cell Death; Energy Metabolism; Female; Fe | 2000 |