lactic acid has been researched along with Hepatic Encephalopathy in 43 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Hepatic Encephalopathy: A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study was to investigate the effects of ammonia and manganese in the metabolism of minimal hepatic encephalopathy (MHE)." | 8.31 | The interaction of ammonia and manganese in abnormal metabolism of minimal hepatic encephalopathy: A comparison metabolomics study. ( Li, Y; Liu, XF; Lu, JJ; Qiang, JW; Yang, XY, 2023) |
| "Data were collected early after admission and again at the time of onset of grade 3-4 hepatic encephalopathy from acetaminophen-induced fulminant hepatic failure." | 7.73 | Prognostic implications of hyperlactatemia, multiple organ failure, and systemic inflammatory response syndrome in patients with acetaminophen-induced acute liver failure. ( Larsen, FS; Schmidt, LE, 2006) |
| "Hyperammonemia is a consistent finding in many metabolic disorders." | 5.31 | The effect of ammonium chloride on metabolism of primary neurons and neuroblastoma cells in vitro. ( Geraminegad, P; Haghighat, N; McCandless, DW, 2000) |
| "This study was to investigate the effects of ammonia and manganese in the metabolism of minimal hepatic encephalopathy (MHE)." | 4.31 | The interaction of ammonia and manganese in abnormal metabolism of minimal hepatic encephalopathy: A comparison metabolomics study. ( Li, Y; Liu, XF; Lu, JJ; Qiang, JW; Yang, XY, 2023) |
| "To identify laboratory diagnostic indicators of hepatic encephalopathy (HE), the present study established a HE diagnostic model to explore the diagnostic value of serum homocysteine, lactic acid, procalcitonin, and bile acid levels in HE identification." | 4.12 | Risk Factor Analysis of Hepatic Encephalopathy and the Establishment of Diagnostic Model. ( Chen, F; Li, F; Li, J; Mao, C; Qu, Y; Tian, S; Wang, Y; Zhang, W, 2022) |
| "Increased brain lactate, and not glutamine, is a primary player in the pathogenesis of brain edema in CLD." | 3.80 | Increased brain lactate is central to the development of brain edema in rats with chronic liver disease. ( Bosoi, CR; Huynh, J; Marin, H; Parent-Robitaille, C; Rose, CF; Tremblay, M; Zwingmann, C, 2014) |
| "Data were collected early after admission and again at the time of onset of grade 3-4 hepatic encephalopathy from acetaminophen-induced fulminant hepatic failure." | 3.73 | Prognostic implications of hyperlactatemia, multiple organ failure, and systemic inflammatory response syndrome in patients with acetaminophen-induced acute liver failure. ( Larsen, FS; Schmidt, LE, 2006) |
| "Brain alterations such as hepatic encephalopathy or brain edema are usually associated with liver failure." | 2.50 | Magnetic resonance of the brain in chronic and acute liver failure. ( Chavarria, L; Cordoba, J, 2014) |
| " In a separate dose-response experiment cortex from healthy rats was incubated for 120 min in ammonium acetate in concentrations up to 80 mM prior to respirometry." | 1.46 | Accumulation of lactate in the rat brain during hyperammonaemia is not associated with impaired mitochondrial respiratory capacity. ( Bjerring, PN; Larsen, FS; Witt, AM, 2017) |
| "We investigated the association between hepatic encephalopathy (HE) scores, abnormal EEG or neuroimaging, and short-term outcome." | 1.40 | EEG abnormalities are associated with increased risk of transplant or poor outcome in children with acute liver failure. ( Alonso, E; Goldstein, J; Grimason, M; Hussain, E; Smith, CM; Wainwright, MS; Whitington, PF, 2014) |
| "Patients with acute liver failure have a disturbed amino acid metabolism and a compromised oxidative metabolism in the brain." | 1.38 | The effect of fractionated plasma separation and adsorption on cerebral amino acid metabolism and oxidative metabolism during acute liver failure. ( Bjerring, PN; Clemmesen, JO; Frederiksen, HJ; Hauerberg, J; Larsen, FS; Nielsen, HB, 2012) |
| " The quantity of red blood cell infusion, blood loss and the dosage of noradrenalin in encephalopathy group were significantly larger compared with non-encephalopathy group." | 1.37 | [Peri-operative characteristics of cerebral oxygen metabolism in patients with encephalopathy after orthotopic liver transplantation]. ( Cai, J; Hei, ZQ; Shen, N; Sun, HY, 2011) |
| "Fulminant hepatic encephalopathy has a high mortality." | 1.33 | Microdialysis in the management of hepatic encephalopathy. ( Al-Rawi, PG; Czosnyka, M; Gimson, A; Hutchinson, PJ; Menon, DK; O'Connell, MT, 2006) |
| "Hyperammonemia is a consistent finding in many metabolic disorders." | 1.31 | The effect of ammonium chloride on metabolism of primary neurons and neuroblastoma cells in vitro. ( Geraminegad, P; Haghighat, N; McCandless, DW, 2000) |
| "Patients with severe acute alcoholic hepatitis develop multiple organ failure which is associated with production of inflammatory cytokines and a poor prognosis." | 1.30 | Temporary extracorporeal liver support for severe acute alcoholic hepatitis using the BioLogic-DT. ( Ellis, AJ; Hughes, RD; Langley, PG; Nicholl, D; O'Grady, JG; Wendon, JA; Williams, R, 1999) |
| "Loss of righting reflex (precoma stage of PSE) was accompanied by 2-3 fold increased CSF lactate and onset of coma by 4-fold increases of lactate (p less than 0." | 1.28 | Increased cerebrospinal fluid lactate reflects deterioration of neurological status in experimental portal-systemic encephalopathy. ( Butterworth, RF; Giguère, JF; Therrien, G, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (9.30) | 18.7374 |
| 1990's | 13 (30.23) | 18.2507 |
| 2000's | 9 (20.93) | 29.6817 |
| 2010's | 12 (27.91) | 24.3611 |
| 2020's | 5 (11.63) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, F | 1 |
| Li, J | 1 |
| Zhang, W | 1 |
| Mao, C | 1 |
| Wang, Y | 3 |
| Qu, Y | 1 |
| Tian, S | 1 |
| Li, F | 1 |
| Liu, XF | 2 |
| Lu, JJ | 2 |
| Li, Y | 3 |
| Yang, XY | 2 |
| Qiang, JW | 2 |
| Li, H | 1 |
| Su, HB | 1 |
| Wang, YG | 1 |
| Yan, LL | 1 |
| Peng, YH | 1 |
| Li, C | 1 |
| Liu, XY | 1 |
| Hu, JH | 1 |
| Ning, P | 1 |
| Guan, CD | 1 |
| Simicic, D | 1 |
| Rackayova, V | 1 |
| Braissant, O | 1 |
| Toso, C | 1 |
| Oldani, G | 1 |
| Sessa, D | 1 |
| McLin, VA | 1 |
| Cudalbu, C | 1 |
| Chavarria, L | 1 |
| Cordoba, J | 1 |
| Oria, M | 1 |
| Jalan, R | 1 |
| Hussain, E | 1 |
| Grimason, M | 1 |
| Goldstein, J | 1 |
| Smith, CM | 1 |
| Alonso, E | 1 |
| Whitington, PF | 1 |
| Wainwright, MS | 1 |
| Bosoi, CR | 2 |
| Zwingmann, C | 2 |
| Marin, H | 1 |
| Parent-Robitaille, C | 1 |
| Huynh, J | 1 |
| Tremblay, M | 1 |
| Rose, CF | 3 |
| Hertz, L | 1 |
| Song, D | 1 |
| Peng, L | 1 |
| Chen, Y | 1 |
| Witt, AM | 1 |
| Larsen, FS | 4 |
| Bjerring, PN | 2 |
| Mei, L | 1 |
| Qiang, J | 1 |
| Ju, S | 1 |
| Zhao, S | 1 |
| Bengmark, S | 1 |
| Cai, J | 1 |
| Sun, HY | 1 |
| Shen, N | 1 |
| Hei, ZQ | 1 |
| Rama Rao, KV | 1 |
| Norenberg, MD | 1 |
| Hauerberg, J | 1 |
| Frederiksen, HJ | 1 |
| Nielsen, HB | 1 |
| Clemmesen, JO | 2 |
| Chatauret, N | 2 |
| Leibfritz, D | 1 |
| Butterworth, RF | 3 |
| Schmidt, LE | 1 |
| Hutchinson, PJ | 1 |
| Gimson, A | 1 |
| Al-Rawi, PG | 1 |
| O'Connell, MT | 1 |
| Czosnyka, M | 1 |
| Menon, DK | 1 |
| Waring, MA | 1 |
| Sun, J | 3 |
| Woodman, K | 3 |
| Mears, DC | 3 |
| Johnston, B | 3 |
| Jung, SE | 1 |
| Horvat, M | 3 |
| Koutalistras, N | 3 |
| Watson, KJ | 2 |
| Sheil, AG | 3 |
| Waring, M | 2 |
| Wang, LS | 1 |
| Nyberg, SL | 2 |
| Cerra, FB | 1 |
| Gruetter, R | 2 |
| Watson, J | 1 |
| Wang, L | 1 |
| Weisdorf, SA | 1 |
| Rajanayagan, V | 1 |
| Terpstra, M | 1 |
| Merkle, H | 1 |
| Truwit, CL | 1 |
| Garwood, M | 1 |
| Uğurbil, K | 1 |
| Ellis, AJ | 1 |
| Hughes, RD | 1 |
| Nicholl, D | 1 |
| Langley, PG | 1 |
| Wendon, JA | 1 |
| O'Grady, JG | 1 |
| Williams, R | 1 |
| Li, M | 1 |
| Walsh, TS | 1 |
| McLellan, S | 1 |
| Mackenzie, SJ | 1 |
| Lee, A | 1 |
| Haghighat, N | 1 |
| McCandless, DW | 1 |
| Geraminegad, P | 1 |
| Høy, CE | 1 |
| Kondrup, J | 1 |
| Ott, P | 1 |
| Blüml, S | 1 |
| Moreno, A | 1 |
| Hwang, JH | 1 |
| Ross, BD | 1 |
| Rose, C | 1 |
| Therrien, G | 2 |
| de Graaf, AA | 1 |
| Deutz, NE | 1 |
| Bosman, DK | 2 |
| Chamuleau, RA | 2 |
| de Haan, JG | 1 |
| Bovee, WM | 2 |
| van Dijk, JE | 1 |
| Giguère, JF | 1 |
| Davenport, A | 1 |
| Davison, AM | 1 |
| Will, EJ | 1 |
| Höring, E | 1 |
| Kubin, S | 1 |
| von Gaisberg, U | 1 |
| Yao, H | 1 |
| Sadoshima, S | 1 |
| Fujii, K | 1 |
| Kusuda, K | 1 |
| Ishitsuka, T | 1 |
| Tamaki, K | 1 |
| Fujishima, M | 1 |
| Zhou, MX | 1 |
| Chang, TM | 1 |
| Kleinberger, G | 1 |
| Gregersen, N | 1 |
7 reviews available for lactic acid and Hepatic Encephalopathy
| Article | Year |
|---|---|
Magnetic resonance of the brain in chronic and acute liver failure.
Topics: Aspartic Acid; Biomarkers; Brain; Brain Chemistry; Brain Edema; Choline; Creatine; Glutamic Acid; Gl | 2014 |
Elevated cerebral lactate: Implications in the pathogenesis of hepatic encephalopathy.
Topics: Ammonia; Animals; Brain; Brain Edema; Citric Acid Cycle; Dichloroacetic Acid; Drug Evaluation, Precl | 2014 |
Multifactorial Effects on Different Types of Brain Cells Contribute to Ammonia Toxicity.
Topics: Ammonia; Animals; Astrocytes; Brain; Cyclic GMP; Energy Metabolism; Glutamine; Hepatic Encephalopath | 2017 |
Bio-ecological control of chronic liver disease and encephalopathy.
Topics: Dietary Proteins; Feeding Behavior; Food, Formulated; Hepatic Encephalopathy; Humans; Inflammation; | 2009 |
Increase brain lactate in hepatic encephalopathy: cause or consequence?
Topics: Animals; Biological Transport, Active; Brain Chemistry; Brain Edema; Energy Metabolism; Hepatic Ence | 2010 |
Brain energy metabolism and mitochondrial dysfunction in acute and chronic hepatic encephalopathy.
Topics: Acute Disease; Ammonia; Brain; Chronic Disease; Citric Acid Cycle; Energy Metabolism; Glycolysis; He | 2012 |
The acyl-CoA dehydrogenation deficiencies. Recent advances in the enzymic characterization and understanding of the metabolic and pathophysiological disturbances in patients with acyl-CoA dehydrogenation deficiencies.
Topics: Acidosis; Acyl Coenzyme A; Acyl-CoA Dehydrogenase, Long-Chain; Ammonia; Carboxylic Acids; Chemical P | 1985 |
36 other studies available for lactic acid and Hepatic Encephalopathy
| Article | Year |
|---|---|
Risk Factor Analysis of Hepatic Encephalopathy and the Establishment of Diagnostic Model.
Topics: Bile Acids and Salts; Factor Analysis, Statistical; Hepatic Encephalopathy; Homocysteine; Humans; La | 2022 |
Ferrous sulfate reverses cerebral metabolic abnormality induced by minimal hepatic encephalopathy.
Topics: Animals; Arginine; Aspartic Acid; Brain; Glutamic Acid; Glycine; Hepatic Encephalopathy; Iron; Lacti | 2023 |
[Analysis of the clinical predictive value of lactate on the prognosis of patients with acute-on-chronic liver failure combined with infection].
Topics: Acute-On-Chronic Liver Failure; Bilirubin; Hepatic Encephalopathy; Humans; Lactic Acid; Prognosis; R | 2023 |
Neurometabolic changes in a rat pup model of type C hepatic encephalopathy depend on age at liver disease onset.
Topics: Adult; Animals; Brain; Child; Glutamine; Hepatic Encephalopathy; Humans; Lactic Acid; Liver Diseases | 2023 |
The interaction of ammonia and manganese in abnormal metabolism of minimal hepatic encephalopathy: A comparison metabolomics study.
Topics: Alanine; Ammonia; Animals; Arginine; Brain; Citrulline; gamma-Aminobutyric Acid; Glutamic Acid; Glut | 2023 |
Brain lactate in hepatic encephalopathy: friend or foe?
Topics: Animals; Brain; Brain Edema; Hepatic Encephalopathy; Lactic Acid; Liver Diseases; Male | 2014 |
EEG abnormalities are associated with increased risk of transplant or poor outcome in children with acute liver failure.
Topics: Alanine Transaminase; Aspartate Aminotransferases; Child; Child, Preschool; Electroencephalography; | 2014 |
Increased brain lactate is central to the development of brain edema in rats with chronic liver disease.
Topics: Ammonia; Animals; Brain; Brain Edema; Chronic Disease; Glutamine; Hepatic Encephalopathy; Lactic Aci | 2014 |
Accumulation of lactate in the rat brain during hyperammonaemia is not associated with impaired mitochondrial respiratory capacity.
Topics: Animals; Biosensing Techniques; Brain Chemistry; Cerebral Cortex; Citric Acid Cycle; Encephalitis; H | 2017 |
Magnetic Resonance Spectroscopy for Evaluating Portal-Systemic Encephalopathy in Patients with Chronic Hepatic Schistosomiasis Japonicum.
Topics: Aged; Aged, 80 and over; Ammonia; Brain; Chronic Disease; Female; Globus Pallidus; Glutamine; Hepati | 2016 |
[Peri-operative characteristics of cerebral oxygen metabolism in patients with encephalopathy after orthotopic liver transplantation].
Topics: Adult; Blood Glucose; Brain; Female; Hepatic Encephalopathy; Humans; Lactic Acid; Liver Transplantat | 2011 |
The effect of fractionated plasma separation and adsorption on cerebral amino acid metabolism and oxidative metabolism during acute liver failure.
Topics: Adult; Amino Acids; Cerebrum; Dialysis Solutions; Extracorporeal Circulation; Female; Glutamine; Hep | 2012 |
Selective increase of brain lactate synthesis in experimental acute liver failure: results of a [H-C] nuclear magnetic resonance study.
Topics: Amino Acids; Ammonia; Animals; Blood; Body Water; Brain; Brain Edema; Carbon Isotopes; Glucose; Hepa | 2003 |
Prognostic implications of hyperlactatemia, multiple organ failure, and systemic inflammatory response syndrome in patients with acetaminophen-induced acute liver failure.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Child; Female; Hepatic Encephalopa | 2006 |
Is it worthwhile to use cerebral microdialysis in patients with acute liver failure?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Blood Glucose; Bra | 2006 |
Microdialysis in the management of hepatic encephalopathy.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Blood Glucose; Brain; Brain Edema; Critical Care; Dextropro | 2006 |
Metabolic aspects of cultured hepatocytes for use in a bioartificial liver support system.
Topics: Ammonia; Animals; Artificial Organs; Blood Proteins; Capsules; Cells, Cultured; Culture Media; Fibri | 1995 |
Preclinical trial of a bioartificial liver support system in a porcine fulminant hepatic failure model.
Topics: Amino Acids; Ammonia; Animals; Artificial Organs; Extracorporeal Circulation; Fibrinogen; Hepatic En | 1996 |
Brain lactate by magnetic resonance spectroscopy during fulminant hepatic failure in the dog.
Topics: Animals; Biomarkers; Brain; Dogs; Dose-Response Relationship, Drug; Feasibility Studies; Galactosami | 1998 |
Positive biochemical effects of a bioartificial liver support system (BALSS) in a porcine fulminant hepatic failure (FHF) model.
Topics: Adenosine Triphosphate; Amino Acids; Ammonia; Animals; Bioreactors; Cell Adhesion; Cells, Cultured; | 1998 |
Resolution improvements in in vivo 1H NMR spectra with increased magnetic field strength.
Topics: Adult; Amino Acids; Animals; Brain Chemistry; Dogs; Hepatic Encephalopathy; Humans; Image Processing | 1998 |
Temporary extracorporeal liver support for severe acute alcoholic hepatitis using the BioLogic-DT.
Topics: Acute Disease; Adult; Ammonia; Biocompatible Materials; Blood Coagulation; Cytokines; Female; Hepati | 1999 |
[Liver support effect of experimental extracorporeal bioartificial liver].
Topics: Animals; Cells, Cultured; Dogs; Female; Hepatic Encephalopathy; Humans; Lactic Acid; Liver, Artifici | 1999 |
Hyperlactatemia and pulmonary lactate production in patients with fulminant hepatic failure.
Topics: Critical Illness; Female; Hepatic Encephalopathy; Humans; Lactic Acid; Lung; Male; Prospective Studi | 1999 |
The effect of ammonium chloride on metabolism of primary neurons and neuroblastoma cells in vitro.
Topics: Adenosine Triphosphate; Ammonium Chloride; Animals; Brain; Cell Death; Energy Metabolism; Female; Fe | 2000 |
Splanchnic metabolism of fuel substrates in acute liver failure.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acute Kidney Injury; Adult; Blood Glucose; Female; Hepatic Enc | 2000 |
1-(13)C glucose magnetic resonance spectroscopy of pediatric and adult brain disorders.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain; Brain Diseases; Canavan Disease; Carbon Isotopes; Chi | 2001 |
Mild hypothermia prevents cerebral edema and CSF lactate accumulation in acute liver failure.
Topics: Ammonia; Animals; Brain; Brain Edema; Energy Metabolism; Hepatic Encephalopathy; Hypothermia, Induce | 2001 |
The use of in vivo proton NMR to study the effects of hyperammonemia in the rat cerebral cortex.
Topics: Ammonia; Animals; Cerebral Cortex; Choline; Glutamates; Glutamic Acid; Glutamine; Hepatic Encephalop | 1991 |
A localized in vivo detection method for lactate using zero quantum coherence techniques.
Topics: Animals; Brain; Hepatic Encephalopathy; In Vitro Techniques; Lactates; Lactic Acid; Magnetic Resonan | 1991 |
Increased cerebrospinal fluid lactate reflects deterioration of neurological status in experimental portal-systemic encephalopathy.
Topics: Animals; Coma; Energy Metabolism; Hepatic Encephalopathy; Lactates; Lactic Acid; Male; Postural Bala | 1991 |
The prognostic use of a lactate infusion in patients with severe hepatorenal failure.
Topics: Adult; Aged; Female; Hemofiltration; Hepatic Encephalopathy; Humans; Kidney Failure, Chronic; Lactat | 1991 |
[Spontaneous bacterial peritonitis: studies of the incidence and clinical and laboratory chemical parameters].
Topics: Ascitic Fluid; Bacterial Infections; Bacteriological Techniques; Blood Glucose; Blood Proteins; Chol | 1990 |
Cerebrospinal fluid lactate in patients with hepatic encephalopathy.
Topics: Acid-Base Equilibrium; Brain; Carbon Dioxide; Female; Glycolysis; Hepatic Encephalopathy; Humans; La | 1987 |
Effects of polylactic acid microcapsules containing prostaglandin E2 on the survival rates of grade II coma galactosamine induced fulminant hepatic failure rats.
Topics: Animals; Capsules; Delayed-Action Preparations; Dinoprostone; Galactosamine; Hepatic Encephalopathy; | 1987 |
[Assessment of liver function by metabolic parameters].
Topics: Amino Acids; Blood Glucose; Blood Proteins; Critical Care; Energy Metabolism; Hepatic Encephalopathy | 1987 |