lactic acid has been researched along with Hemorrhagic Shock in 207 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In order to study the clinical effects of naloxone on hemorrhagic shock, 21 patients with moderate hemorrhagic shock were randomly divided into two groups." | 9.08 | [Clinical effects of naloxone on hemorrhagic shock]. ( Lu, H; Sheng, Z; Xu, G, 1995) |
| "To compare the effect of various fluid resuscitation procedures after hemorrhagic shock on the lactic acid accumulation by network meta-analysis." | 7.91 | The influence of different resuscitation solution on lactic acid accumulation after hemorrhagic shock: a network meta-analysis. ( Chen, WX; Li, ZB; Wen, DL; Wu, XQ; Xiong, XM; Zhang, ZH, 2019) |
| "Therapeutic effects of continuous intravenous infusions of solvent-free low doses of resveratrol on organ injury and systemic consequences resulting from severe hemorrhagic shock in rats were studied." | 7.85 | Attenuation of Multiple Organ Damage by Continuous Low-Dose Solvent-Free Infusions of Resveratrol after Severe Hemorrhagic Shock in Rats. ( Kirsch, M; Müller, T; Petrat, F, 2017) |
| "Lactic acidosis is a life-threatening complication of hemorrhagic shock." | 7.79 | Pyruvate Ringer's solution corrects lactic acidosis and prolongs survival during hemorrhagic shock in rats. ( Bai, XD; Fang, T; Hu, S; Liu, XQ; Wang, HB; Zhong, YX; Zhou, FQ, 2013) |
| "Diaspirin cross-linked hemoglobin (DCLHb) has demonstrated a pressor effect that could adversely affect traumatic hemorrhagic shock patients through diminished perfusion to vital organs, causing base deficit (BD) and lactate abnormalities." | 7.76 | Diaspirin cross-linked hemoglobin infusion did not influence base deficit and lactic acid levels in two clinical trials of traumatic hemorrhagic shock patient resuscitation. ( Gao, W; Koenigsberg, MD; Philbin, NB; Sloan, EP, 2010) |
| "To evaluate the effects of methylene blue (MB) on refractory hemorrhagic shock." | 7.74 | [Effects of methylene blue on refractory hemorrhagic shock]. ( Wang, HL; Wang, Z; Yu, CH; Yu, XZ; Zhu, HD, 2008) |
| "Hemorrhagic shock altered the pharmacokinetics and pharmacodynamics of propofol." | 7.72 | The influence of hemorrhagic shock on propofol: a pharmacokinetic and pharmacodynamic analysis. ( Church, T; Egan, TD; Johnson, KB; Kern, SE; McJames, SW; Syroid, N; Whiddon, D; White, JL, 2003) |
| "Resuscitation after refractory hemorrhagic shock using a combination of methylene blue and limited-volume lactated Ringer's solution improves prehospital survival and hemodynamic stability and reduces ischemic damage in an acute setting." | 7.72 | Methylene blue enhancement of resuscitation after refractory hemorrhagic shock. ( Chitwood, WR; Ghiassi, S; Kim, VB; Nifong, LW; Rotondo, MF; Scott, CM; Sun, YS, 2004) |
| "Hemorrhagic shock is associated with lactic acidosis and increased plasma catecholamines." | 7.70 | Adrenergic antagonists reduce lactic acidosis in response to hemorrhagic shock. ( Frame, SB; Friend, LA; James, JH; Luchette, FA; McCarter, F; Robinson, BR, 1999) |
| "A patient with acute copper sulfate poisoning was found to have maintained a relatively oxidized hepatic mitochondrial redox state in spite of his being in refractory shock." | 7.69 | Redox state in liver mitochondria in acute copper sulfate poisoning. ( Kobayashi, K; Nakatani, T; Spolter, L, 1994) |
| "In this acute, nonresuscitated, canine hemorrhagic shock model, pentoxifylline did not act as a vasodilator, or have any significant effect on HR, cardiac output, oxygen transport, or lactic acidosis." | 7.68 | Effects of pentoxifylline on hemodynamics, oxygen transport, and tissue metabolism in experimental, severe hemorrhagic shock. ( Amin, D; Benjamin, E; Fischer, E; Iberti, TJ; Jacobs, E; Klapholtz, A; Oropello, JM, 1991) |
| "The influence of hemorrhagic shock on hepatic energy metabolism was investigated in carbon tetrachloride (CCl4)-induced cirrhotic rat." | 7.67 | Influence of hemorrhagic shock on hepatic energy metabolism in carbon tetrachloride-induced cirrhotic rats. ( Ikai, I; Morimoto, T; Ozaki, N; Ozawa, K; Shimahara, Y; Tanaka, A; Tokunaga, Y; Wakashiro, S, 1988) |
| "Metabolic acidosis is one of the many metabolic derangements triggered by severe trauma/hemorrhagic shock, also including enhanced proteolysis, lipid mobilization, as well as traumatic diabetes." | 5.43 | Plasma First Resuscitation Reduces Lactate Acidosis, Enhances Redox Homeostasis, Amino Acid and Purine Catabolism in a Rat Model of Profound Hemorrhagic Shock. ( Banerjee, A; Chapman, MP; D'Alessandro, A; Fragoso, M; Gonzalez, E; Hansen, KC; Moore, EE; Moore, HB; Morton, AP; Nemkov, T; Sauaia, A; Silliman, CC; Slaughter, A; Wither, MJ, 2016) |
| "Deltorphin E was investigated as a pharmaceutical intervention in the ischemic hemorrhagic model." | 5.35 | Post-treatment with the novel deltorphin E, a delta2-opioid receptor agonist, increases recovery and survival after severe hemorrhagic shock in behaving rats. ( Govindaswami, M; Oeltgen, P; Rutten, M; Sonneborn, JS, 2008) |
| "Prolonged hemorrhagic shock is characterized by the progression from hyperglycemia to hypoglycemia and failure to respond to standard methods of resuscitation." | 5.29 | Diltiazem preserves hepatic gluconeogenesis following hemorrhagic shock. ( Drourr, N; Geller, ER; Higgins, LD; Maitra, SR, 1993) |
| "Diltiazem treatment significantly reduced the plasma glucose and heart rate during hemorrhagic shock (P less than 0." | 5.28 | Beneficial effects of diltiazem in hemorrhagic shock. ( Dulchavsky, SA; Geller, ER; Kreis, DJ; Krikhely, M; Maitra, SR, 1991) |
| "In order to study the clinical effects of naloxone on hemorrhagic shock, 21 patients with moderate hemorrhagic shock were randomly divided into two groups." | 5.08 | [Clinical effects of naloxone on hemorrhagic shock]. ( Lu, H; Sheng, Z; Xu, G, 1995) |
| " This review discusses 3 issues that concern homeostasis in the acute care of trauma patients directly related to the stress response: hyperglycemia, lactic acidosis, and hypothermia." | 4.89 | Trauma and aggressive homeostasis management. ( Baranov, D; Neligan, PJ, 2013) |
| "Three important issues concerning homeostasis in the acute care of trauma patients that are related directly to the stress response are hyperglycemia, lactic acidosis, and hypothermia." | 4.84 | Trauma and aggressive homeostasis management. ( Baranov, D; Neligan, P, 2007) |
| "Therapeutic effects of continuous intravenous infusions of solvent-free low doses of resveratrol on organ injury and systemic consequences resulting from severe hemorrhagic shock in rats were studied." | 3.85 | Attenuation of Multiple Organ Damage by Continuous Low-Dose Solvent-Free Infusions of Resveratrol after Severe Hemorrhagic Shock in Rats. ( Kirsch, M; Müller, T; Petrat, F, 2017) |
| "This study examined the effects of polyethylene oxide (PEO) on the survival rate, hemodynamics, blood gas indexes, lactic acid levels, microcirculation, and inflammatory cytokine levels in rats subjected to severe hemorrhagic shock." | 3.81 | Protective effects of polyethylene oxide on the vascular and organ function of rats with severe hemorrhagic shock. ( Dong, Z; Huang, T; Li, Q, 2015) |
| "Flutamide failed to show any benefit to resuscitation in a model of severe injury and was associated with increased acidosis, hemodilution, and liver injury compared with standard crystalloid resuscitation." | 3.79 | Flutamide fails to reduce resuscitation requirements in a porcine ischemia-reperfusion model. ( Hempel, J; Hoffer, Z; Martin, M; Satterly, SA; Stallings, JD; Wingerd, M, 2013) |
| "Lactic acidosis is a life-threatening complication of hemorrhagic shock." | 3.79 | Pyruvate Ringer's solution corrects lactic acidosis and prolongs survival during hemorrhagic shock in rats. ( Bai, XD; Fang, T; Hu, S; Liu, XQ; Wang, HB; Zhong, YX; Zhou, FQ, 2013) |
| " We investigated the effect of the LXRα agonist, T0901317, on lung inflammation in a rodent model of hemorrhagic shock." | 3.77 | Liver X receptor α activation with the synthetic ligand T0901317 reduces lung injury and inflammation after hemorrhage and resuscitation via inhibition of the nuclear factor κB pathway. ( Denenberg, A; Hake, PW; Lentsch, A; O'Connor, M; Piraino, G; Solan, PD; Zingarelli, B, 2011) |
| "Diaspirin cross-linked hemoglobin (DCLHb) has demonstrated a pressor effect that could adversely affect traumatic hemorrhagic shock patients through diminished perfusion to vital organs, causing base deficit (BD) and lactate abnormalities." | 3.76 | Diaspirin cross-linked hemoglobin infusion did not influence base deficit and lactic acid levels in two clinical trials of traumatic hemorrhagic shock patient resuscitation. ( Gao, W; Koenigsberg, MD; Philbin, NB; Sloan, EP, 2010) |
| "To evaluate the effects of methylene blue (MB) on refractory hemorrhagic shock." | 3.74 | [Effects of methylene blue on refractory hemorrhagic shock]. ( Wang, HL; Wang, Z; Yu, CH; Yu, XZ; Zhu, HD, 2008) |
| "Hemorrhagic shock altered the pharmacokinetics and pharmacodynamics of propofol." | 3.72 | The influence of hemorrhagic shock on propofol: a pharmacokinetic and pharmacodynamic analysis. ( Church, T; Egan, TD; Johnson, KB; Kern, SE; McJames, SW; Syroid, N; Whiddon, D; White, JL, 2003) |
| " The animals developed severe lactic acidosis between 30 and 90 min, which was accompanied by a trend for initial rise and subsequent 40% drop of CH50/mL, indicating massive C activation even before resuscitation, i." | 3.72 | Complement activation during hemorrhagic shock and resuscitation in swine. ( Alving, CR; Baranyi, L; Bünger, R; Götze, O; Mongan, PD; Savay, S; Szebeni, J, 2003) |
| "Resuscitation after refractory hemorrhagic shock using a combination of methylene blue and limited-volume lactated Ringer's solution improves prehospital survival and hemodynamic stability and reduces ischemic damage in an acute setting." | 3.72 | Methylene blue enhancement of resuscitation after refractory hemorrhagic shock. ( Chitwood, WR; Ghiassi, S; Kim, VB; Nifong, LW; Rotondo, MF; Scott, CM; Sun, YS, 2004) |
| " This study evaluates the effects of hemorrhagic shock, with and without combined alpha- and beta-adrenergic receptor blockade, on lactate production, glycogenolysis, Na(+)-K(+) pump activity, and high-energy phosphates in rat skeletal muscle." | 3.71 | Adrenergic blockade reduces skeletal muscle glycolysis and Na(+), K(+)-ATPase activity during hemorrhage. ( Evans, JM; Fischer, JE; Friend, LA; George, MA; James, JH; King, JK; Luchette, FA; McCarter, FD; Wang, L, 2001) |
| "Hemorrhagic shock is associated with lactic acidosis and increased plasma catecholamines." | 3.70 | Adrenergic antagonists reduce lactic acidosis in response to hemorrhagic shock. ( Frame, SB; Friend, LA; James, JH; Luchette, FA; McCarter, F; Robinson, BR, 1999) |
| "We investigated the effect of hemorrhagic shock and reinfusion on the cardiac function and contractility, plasma CK and CK-MB activity and lactate concentration, oxyradical-producing activity of polymorphonuclear leukocytes (PMNL-CL), cardiac chemiluminescence (LV-CL), antioxidant enzyme activity [superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-PX)] and malondialdehyde (MDA) concentration in anesthetized dogs to determine the role of oxyradicals in cardiac depression and cellular injury in hemorrhagic shock and reinfusion." | 3.69 | Cardiac depression and cellular injury in hemorrhagic shock and reinfusion: role of free radicals. ( Kalra, J; Kapoor, R; Prasad, K, 1997) |
| "A patient with acute copper sulfate poisoning was found to have maintained a relatively oxidized hepatic mitochondrial redox state in spite of his being in refractory shock." | 3.69 | Redox state in liver mitochondria in acute copper sulfate poisoning. ( Kobayashi, K; Nakatani, T; Spolter, L, 1994) |
| "We investigated the effects of hemorrhagic shock and reinfusion on the cardiac function and contractility, plasma CK and CK-MB activity and lactate concentration, oxyradical-producing activity of polymorphonuclear leukocytes (PMNL-CL), cardiac chemiluminescence (LV-CL), antioxidant enzymatic activity [superoxide dismutase (SOD), catalase, glutathione peroxidase (GSH-Px)], and malondialdehyde (MDA) concentration in anesthetized dogs, to determine the role of oxyradicals in cardiac depression and cellular injury in hemorrhagic shock and reinfusion." | 3.69 | Role of oxyradicals in cardiovascular depression and cellular injury in hemorrhagic shock and reinfusion: effect of SOD and catalase. ( Kapoor, R; Prasad, K, 1994) |
| "In this acute, nonresuscitated, canine hemorrhagic shock model, pentoxifylline did not act as a vasodilator, or have any significant effect on HR, cardiac output, oxygen transport, or lactic acidosis." | 3.68 | Effects of pentoxifylline on hemodynamics, oxygen transport, and tissue metabolism in experimental, severe hemorrhagic shock. ( Amin, D; Benjamin, E; Fischer, E; Iberti, TJ; Jacobs, E; Klapholtz, A; Oropello, JM, 1991) |
| "The influence of hemorrhagic shock on hepatic energy metabolism was investigated in carbon tetrachloride (CCl4)-induced cirrhotic rat." | 3.67 | Influence of hemorrhagic shock on hepatic energy metabolism in carbon tetrachloride-induced cirrhotic rats. ( Ikai, I; Morimoto, T; Ozaki, N; Ozawa, K; Shimahara, Y; Tanaka, A; Tokunaga, Y; Wakashiro, S, 1988) |
| " In contrast to the liver, soleus muscle showed no change in the levels of glycogen, ATP, CrP, free creatine, or total creatine compared to time-matched controls in any phase of hemorrhagic shock suggesting the absence of significant muscle ischemia." | 3.67 | Phase-related changes in tissue energy reserves during hemorrhagic shock. ( Connett, RJ; Drucker, WR; Pearce, FJ, 1985) |
| "Thus, reducing the severity of hemorrhagic shock appears to be one mechanism of prehospital plasma benefit." | 3.01 | Lactate as a mediator of prehospital plasma mortality reduction in hemorrhagic shock. ( Brown, JB; Canton, SP; Claridge, JA; Daley, BJ; Guyette, FX; Harbrecht, BG; Lutfi, W; Miller, RS; Phelan, HA; Sperry, JL, 2021) |
| "Group IV mice had the least acute lung injury, with no detectable interleukin-6 response." | 2.70 | Improved resuscitation minimizes respiratory dysfunction and blunts interleukin-6 and nuclear factor-kappa B activation after traumatic hemorrhage. ( Claridge, JA; Schulman, AM; Young, JS, 2002) |
| "According to the early response, hemorrhagic shock, circulating interleukin-6, need for vasopressor therapy, subsequent organ dysfunction and infection, and outcomes were studied." | 2.70 | Cortisol response to corticotropin stimulation in trauma patients: influence of hemorrhagic shock. ( Asehnoune, K; Benhamou, D; Brailly-Tabard, S; Edouard, AR; Hoen, S; Mazoit, JX; Moine, P, 2002) |
| "In addition, the management of hemorrhagic shock is continuing to evolve and challenge the dogmatic practices of normotensive resuscitation." | 2.42 | Targeted resuscitation strategies after injury. ( Bilkovski, RN; Horst, HM; Rivers, EP, 2004) |
| "Twelve pigs were subjected to hemorrhagic shock and 45 min of REBOA." | 1.91 | Elamipretide mitigates ischemia-reperfusion injury in a swine model of hemorrhagic shock. ( Ewer, N; Ford, R; Hoareau, GL; Johnson, MA; Neff, LP; Patel, N; Van Brocklin, MW; Vapniarsky, N; Williams, TK; Youngquist, ST, 2023) |
| "Severe hyperlactatemia was associated with death in the ICU (p < 0." | 1.72 | Severe hyperlactatemia in unselected surgical patients: retrospective analysis of prognostic outcome factors. ( Claus, S; Fichtner-Feigl, S; Kousoulas, L; Lederer, AK; Runkel, M; Spiegelberg, J; Utzolino, S, 2022) |
| "In a rat model of multiple injuries and hemorrhagic shock, early administration of EVs significantly reduced the elevation of lactate and creatinine and did not significantly enhance coagulopathy in rats with acute traumatic coagulopathy." | 1.62 | Extracellular vesicles derived from cardiosphere-derived cells as a potential antishock therapeutic. ( Atai, NA; Bynum, JA; Cap, AP; Chance, TC; Garcia-Marcano, J; Gould, SJ; Keesee, JD; Liu, B; Marban, LS; Moseley, JJ; Peck, KA; R-Borlado, L; Rathbone, CR; Salgado, CL; Wu, X, 2021) |
| "Hemorrhagic shock was induced for 30 minutes while a leg compression device was applied." | 1.51 | Extracorporeal potassium binding for the management of hyperkalemia in an anephric model of crush injury. ( Beyer, CA; Grayson, JK; Hoareau, GL; Kashtan, H; Ross, JD; Stewart, IJ; Walker, L; Wilson, C; Wishy, A, 2019) |
| "A rabbit hemorrhagic shock model was developed by bloodletting from the carotid artery." | 1.46 | Application of pulsed arterial resuscitation in a rabbit model of hemorrhagic shock. ( Qiu, W; Shao, Z; Sun, J; Sun, W; Xu, H, 2017) |
| "It has higher predictive efficacy in septic shock, especially for 28-day prognosis." | 1.46 | Clinical study of a new Modified Early Warning System scoring system for rapidly evaluating shock in adults. ( Cao, Y; Qin, Q; Xia, Y, 2017) |
| "Metabolic acidosis is one of the many metabolic derangements triggered by severe trauma/hemorrhagic shock, also including enhanced proteolysis, lipid mobilization, as well as traumatic diabetes." | 1.43 | Plasma First Resuscitation Reduces Lactate Acidosis, Enhances Redox Homeostasis, Amino Acid and Purine Catabolism in a Rat Model of Profound Hemorrhagic Shock. ( Banerjee, A; Chapman, MP; D'Alessandro, A; Fragoso, M; Gonzalez, E; Hansen, KC; Moore, EE; Moore, HB; Morton, AP; Nemkov, T; Sauaia, A; Silliman, CC; Slaughter, A; Wither, MJ, 2016) |
| "Hemorrhagic shock was induced by incremental (0." | 1.42 | Hypertension and vulnerability to hemorrhagic shock in a rat model. ( Reynolds, PS; Song, KS; Tamariz, FJ; Wayne Barbee, R, 2015) |
| "However, trauma/hemorrhagic shock triggered severe metabolic derangement, resulting in increased glucose levels, lactate and carboxylic acid accumulation." | 1.42 | Trauma/hemorrhagic shock instigates aberrant metabolic flux through glycolytic pathways, as revealed by preliminary (13)C-glucose labeling metabolomics. ( Bacon, AW; Banerjee, A; D'Alessandro, A; Fragoso, M; Hansen, KC; Moore, EE; Nemkov, T; Peltz, ED; Silliman, CC; Slaughter, AL; Wither, M, 2015) |
| "The authors examined the impact of a hemorrhagic shock on the diaphragm." | 1.40 | Diaphragmatic function is preserved during severe hemorrhagic shock in the rat. ( Carreira, S; Coirault, C; Demoule, A; Lê Dinh, M; Poloujadoff, MP; Riou, B; Similowski, T; Soubeyrand, M, 2014) |
| "Pressure-controlled hemorrhagic shock was induced in male Sprague-Dawley rats for 1 hour." | 1.40 | Blood pressure-targeted stepwise resuscitation for hemorrhagic shock in rats. ( Chung, H; Doo, AR; Jo, YH; Kim, J; Kim, K; Kim, MA; Lee, JH; Lee, KB; Lee, MJ; Park, CJ; Rhee, JE, 2014) |
| "Intestinal ischemia-reperfusion injury is one of the main factors leading to multiple organ failure after resuscitation of prolonged hemorrhagic shock; however, the current conventional fluid resuscitation still cannot effectively reduce intestinal injury caused by prolonged hemorrhagic shock." | 1.40 | Utilization of extracorporeal membrane oxygenation alleviates intestinal ischemia-reperfusion injury in prolonged hemorrhagic shock animal model. ( Chen, J; Jia, W; Luo, L; Xiao, J; Xiao, Y; Zhao, L, 2014) |
| "Intestinal ischemia is difficult to diagnose noninvasively." | 1.38 | Increased circulating D-lactate levels predict risk of mortality after hemorrhage and surgical trauma in baboons. ( Bahrami, S; Hölzenbein, T; Khadem, A; Kröpfl, A; Redl, H; Sobhian, B, 2012) |
| "In dogs submitted to pressure-guided hemorrhagic shock and fixed-volume resuscitation, the smaller intravascular volume expansion from HHES solutions provides worse recovery of systemic oxygenation and gastric perfusion compared with LR and HES solutions despite its high volume expansion efficiency, which was limited by low infused volume." | 1.37 | The effects of 6% hydroxyethyl starch-hypertonic saline in resuscitation of dogs with hemorrhagic shock. ( Barros, JM; Braz, JR; Braz, LG; Carvalho, LR; Castiglia, YM; do Nascimento, P; Marinello, JL; Vane, LA, 2011) |
| "End points of resuscitation in trauma patients are difficult to define." | 1.37 | Correlation between IVC dimensions and volume status on CT scan. ( Miraflor, E; Sadjadi, J; Strumwasser, A; Victorino, GP; Yeung, L, 2011) |
| "This experimental protocol of hemorrhagic shock and fluid resuscitation in Landrace-Large White swine may be useful for future study of hemorrhagic shock and acute lung injury." | 1.37 | A model of hemorrhagic shock and acute lung injury in Landrace-Large White Swine. ( Agrogiannis, GD; Balkamou, XA; Demestiha, TD; Pantazopoulos, IN; Rokas, GI; Skandalakis, PN; Stroumpoulis, KI; Troupis, GT; Xanthos, TT, 2011) |
| "Anesthetized rats were assigned to sham; brain injury (BI); controlled hemorrhagic shock (CHS); BI combined with CHS (combined injury [CI]); and CI groups resuscitated with 2." | 1.36 | Moderate Ringer's lactate solution resuscitation yields best neurological outcome in controlled hemorrhagic shock combined with brain injury in rats. ( Brotfain, EM; Dar, DE; Krausz, MM; Leibowitz, A; Semenikhina, L; Shapira, Y; Solopov, A; Soustiel, JF; Zaaroor, M, 2010) |
| "Upon hemorrhagic shock induction, body temperature, mean arterial pressure, mean pulmonary arterial pressure, cardiac output, cardiac index and oxygen delivery decreased, while lactate and shock index increased." | 1.36 | Cardiopulmonary effects of hemorrhagic shock in splenic autotransplanted pigs: a new surgical model. ( Dohan Ehrenfest, DM; Kos, J; Lemo, N; Maticić, D; Nesek-Adam, V; Radisić, B; Rumenjak, V; Vnuk, D, 2010) |
| "The resuscitation strategy for hemorrhagic shock remains controversial, with the kidney being especially prone to hypoxia." | 1.36 | Fluid resuscitation does not improve renal oxygenation during hemorrhagic shock in rats. ( Balestra, GM; Ince, C; Legrand, M; Lutter, R; Mik, EG; Payen, D; Pirracchio, R, 2010) |
| "Rodent model of irreversible hemorrhagic shock was reproduced." | 1.35 | [Hemorrheological changes in irreversible hemorrhagic shock]. ( Su, LY; Wang, B; Wang, ZL; You, GX; Yu, L; Zhao, L; Zhou, H, 2008) |
| "To study this, male rats underwent trauma-hemorrhage (mean blood pressure approximately 40 mmHg for 90 min) followed by fluid resuscitation." | 1.35 | Mechanism of estrogen-mediated intestinal protection following trauma-hemorrhage: p38 MAPK-dependent upregulation of HO-1. ( Bland, KI; Chaudry, IH; Choudhry, MA; Hsieh, CH; Hsu, JT; Kan, WH; Schwacha, MG, 2008) |
| "Early recognition and treatment of hemorrhagic shock after trauma limits multi-organ failure and mortality." | 1.35 | The utility of base deficit and arterial lactate in differentiating major from minor injury in trauma patients with normal vital signs. ( Anderson, T; Paladino, L; Sinert, R; Wallace, D; Yadav, K; Zehtabchi, S, 2008) |
| "Six rats died due to hemorrhagic shock by 350 min (Group D) while six rats had survived for the 350 min period after exsanguination (Group A)." | 1.35 | Utility of microdialysis to detect the lactate/pyruvate ratio in subcutaneous tissue for the reliable monitoring of hemorrhagic shock. ( Fujitani, S; Hosoyama, A; Kawasaki, N; Kobayashi, K; Ohashi, H; Ohashi, M; Taira, Y; Wada, T, 2009) |
| "Deltorphin E was investigated as a pharmaceutical intervention in the ischemic hemorrhagic model." | 1.35 | Post-treatment with the novel deltorphin E, a delta2-opioid receptor agonist, increases recovery and survival after severe hemorrhagic shock in behaving rats. ( Govindaswami, M; Oeltgen, P; Rutten, M; Sonneborn, JS, 2008) |
| "Fluid resuscitation is an important treatment for hemorrhagic shock." | 1.35 | Effects of different fluid resuscitation speeds on blood glucose and interleukin-1 beta in hemorrhagic shock. ( Chao, YF; Hsu, BG; Hu, TM; Lee, RP; Lin, NT; Peng, TC; Subeq, YM, 2009) |
| "A model of rat with severe hemorrhagic shock and active bleeding was established in 32 Sprague-Dawley rats." | 1.34 | Experimental study of controlled fluid resuscitation in the treatment of severe and uncontrolled hemorrhagic shock. ( Bao, DG; Cai, XJ; Gu, LH; Huang, WD; Lu, YQ; Wang, Q, 2007) |
| "Initial fluid resuscitation of hemorrhagic shock might be enhanced by the infusion of monocarboxylate-energy substrates." | 1.34 | Hypertonic 15% sodium pyruvate offers no initial resuscitation advantage compared with 8% hypertonic NACl in sheep with multiple hemorrhages. ( do Nascimento, P; Espana, JM; Hoskins, SL; Kinsky, MP; Kramer, GC; Vaid, SU, 2007) |
| "In this model of hemorrhagic shock, hypertonic HBOC-201- resuscitated pigs had significantly reduced SVR and PVR, as well as mean pulmonary artery pressure (MPAP) and increased cardiac output." | 1.34 | Resuscitation from hemorrhagic shock comparing standard hemoglobin-based oxygen carrier (HBOC)-201 versus 7.5% hypertonic HBOC-201. ( Brown, R; Huerta, S; Minei, JP; Rivera-Chavez, FA; York, GB, 2007) |
| "Hemorrhagic shock was induced in five male domestic pigs." | 1.33 | Increases in both buccal and sublingual partial pressure of carbon dioxide reflect decreases of tissue blood flows in a porcine model during hemorrhagic shock. ( Castillo, C; Csapozi, P; Pellis, T; Sun, S; Tang, W; Weil, MH, 2005) |
| "A model of rat with severe hemorrhagic shock and active bleeding was established in 32 SD (Sprague-Dawley) rats." | 1.33 | Effects of three fluid resuscitation methods on apoptosis of visceral organs in rats with hemorrhagic shock. ( Bao, DG; Cai, XJ; Fan, YJ; Gu, LH; Lu, YQ; Wang, Q, 2005) |
| "Hemorrhagic shock is a common cause of death in emergency rooms." | 1.33 | The physiological changes of cumulative hemorrhagic shock in conscious rats. ( Chang, FM; Chao, YF; Harn, HJ; Lai, HL; Lee, RP; Liao, KW; Peng, TC, 2006) |
| "Treatment with candesartan increased EB extravasation in the kidney in normovolaemic controls." | 1.33 | Effects of candesartan and enalaprilat on the organ-specific microvascular permeability during haemorrhagic shock in rats. ( Binkowski, K; Dendorfer, A; Eichler, W; Klotz, KF; Puchakayala, MR; Schumacher, J, 2006) |
| "Hemorrhagic shock was induced in 48 anesthetized rats by withdrawing 28 mL/kg blood." | 1.33 | Fluid resuscitation with hemoglobin-vesicle solution does not increase hypoxia or inflammatory responses in moderate hemorrhagic shock. ( Goto, Y; Horinouchi, H; Miyashita, M; Sakai, H; Sakamoto, A; Terajima, K; Tsuchida, E; Tsueshita, T, 2006) |
| "The treatment of hemorrhagic shock (HeS) with large volumes of fluid does not ensure an adequate peripheral perfusion or prevent inflammatory activation despite hemodynamic recovery." | 1.32 | Hypertonic saline improves tissue oxygenation and reduces systemic and pulmonary inflammatory response caused by hemorrhagic shock. ( Birolini, D; da Costa Ferreira Novo, F; Fontes, B; Gurfinkel, V; Poggetti, RS, 2003) |
| "In an animal model of severe hemorrhagic shock, there was improvement in hemodynamic stability and a prolonged survival with DADLE treatment." | 1.32 | Effect of a delta receptor agonist on duration of survival during hemorrhagic shock. ( Hildebrandt, D; Li, Z; Summers, RL, 2003) |
| "32 SD rats were randomly divided into four groups: normal group, model group, low dosage group, (treated with Astragalus membranaceus 10 g x kg(-1)); high dosage group (treated with Astragalus membranaceus 20 g x kg(-1))." | 1.32 | [Effects of Astragalus membranaceus injection on nitric oxide and endothelin concentration of intestinal mucosa after hemorrhage shock-reperfusion in rats]. ( Chen, BX; Hei, ZQ; Lin, SQ; Liu, KX; Zhang, JJ, 2004) |
| "We conclude that hemorrhagic shock induces early elevation of phosphomonoesters in skeletal muscle, which correlates with the severity of shock." | 1.32 | Tissue energetics as measured by nuclear magnetic resonance spectroscopy during hemorrhagic shock. ( Beilman, GJ; Conroy, MJ; Gruessner, A; Hammer, BE; Mulier, KE; Myers, D; Taylor, JH, 2004) |
| "Cardiac function decreased during hemorrhagic shock but improved significantly in the UTI group after transfusion compared with the control group." | 1.32 | Protective effect of urinary trypsin inhibitor on myocardial mitochondria during hemorrhagic shock and reperfusion. ( Ikeda, KM; Izumi, T; Masuda, T; Matsunaga, A; Matsuyama, N; Nagasawa, H; Noda, C; Ogura, MN; Sato, K; Shimizu, K, 2003) |
| "We induced hemorrhagic shock by removing a sufficient quantity of blood to maintain a mean arterial pressure of 50 mm Hg or less for 120 min." | 1.31 | The effects of interleukin-10 in hemorrhagic shock. ( Cook, JW; Hinds, M; Karakozis, S; Kim, D; Kirkpatrick, JR; Provido, H, 2000) |
| "In the heart recovering from severe hemorrhagic shock, lactate improves cardiac efficiency in the presence of free fatty acids, possibly by a anaplerosis of the tricarboxylic acid cycle." | 1.31 | Lactate improves cardiac efficiency after hemorrhagic shock. ( Barbee, RW; Kline, JA; Lopaschuk, GD; Thornton, LR; Watts, JA, 2000) |
| "Hemorrhagic shock was created by exsanguination of 31." | 1.31 | Effects of hypertonic saline and dextran 70 on cardiac diastolic function after hemorrhagic shock. ( Ogino, R, 2002) |
| "Lactate production after hemorrhagic shock may be produced by aerobic glycolysis, which has been linked to activity of the Na+/K+ pump in smooth muscle and other tissues." | 1.30 | Increased skeletal muscle Na+, K+-ATPase activity as a cause of increased lactate production after hemorrhagic shock. ( Brown, CC; Friend, LA; James, JH; Luchette, FA; Upputuri, RK, 1998) |
| "Like hemorrhagic shock, highly significant linear correlations were observed between end-tidal PCO2 and cardiac index and between sublingual PCO2 and arterial blood lactate." | 1.30 | Sublingual capnometry for diagnosis and quantitation of circulatory shock. ( Bisera, J; Jin, X; Nakagawa, Y; Sun, S; Tang, W; Weil, MH; Yamaguchi, H, 1998) |
| "This quantitative model of hemorrhagic shock showed that tissue oxygenation parameters can be used to monitor the progression from the decompensated phase of hemorrhagic shock to irreversibility." | 1.30 | Utility of clinical parameters of tissue oxygenation in a quantitative model of irreversible hemorrhagic shock. ( Billiar, TR; Harbrecht, BG; Kelly, E; Marshall, HM; Peitzman, AB; Shah, NS; Udekwu, AO, 1998) |
| "To determine whether blood lactate, base deficit, or oxygen-derived hemodynamic variables correlate with morbidity and mortality rates in a clinically-relevant LD50 model of penetrating trauma." | 1.30 | Prognostic value of blood lactate, base deficit, and oxygen-derived variables in an LD50 model of penetrating trauma. ( Croce, MA; Fabian, TC; Melton, SM; Moomey, CB; Proctor, KG, 1999) |
| "Lactic acidosis was not the cause of the acidemia." | 1.29 | Hypertonic saline-dextran resuscitation from hemorrhagic shock induces transient mixed acidosis. ( Kramer, GC; Moon, PF, 1995) |
| "Prolonged hemorrhagic shock is characterized by the progression from hyperglycemia to hypoglycemia and failure to respond to standard methods of resuscitation." | 1.29 | Diltiazem preserves hepatic gluconeogenesis following hemorrhagic shock. ( Drourr, N; Geller, ER; Higgins, LD; Maitra, SR, 1993) |
| "In 9 dogs with severe hemorrhagic shock, the effect of hemocorrector "Lactoprotein" on the indices of coagulative hemostasis and rheologic blood properties was studied." | 1.28 | [The correction of functional disorders of the hemostatic system and of the rheological properties of the blood in dogs in the late period of hemorrhagic shock by the intravenous transfusion of lactoprotein]. ( Kondratskiĭ, BA; Mindiuk, MV; Oborin, AN; Uspenskiĭ, BA, 1992) |
| "One group was subjected to hemorrhagic shock by rapid withdrawal of blood to a mean arterial pressure of 40 mm Hg and maintained in shock for either 30 or 150 min." | 1.28 | Altered cellular calcium regulation and hepatic glucose production during hemorrhagic shock. ( Geller, ER; Higgins, LD; Kennedy, PR; Maitra, SR; Pan, W, 1992) |
| "Diltiazem treatment significantly reduced the plasma glucose and heart rate during hemorrhagic shock (P less than 0." | 1.28 | Beneficial effects of diltiazem in hemorrhagic shock. ( Dulchavsky, SA; Geller, ER; Kreis, DJ; Krikhely, M; Maitra, SR, 1991) |
| "Hemorrhagic shock was induced by the initial withdrawal of 4 ml of blood followed by 1 ml bleeds at 5, 15, 30, and 60 min to maintain the blood pressure at 40-70 mmHg for 60 min." | 1.27 | Changes in brain thyrotropin-releasing hormone in reversible and irreversible hemorrhagic shock in the rat. ( Mizobe, T; Okuda, C, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (7.25) | 18.7374 |
| 1990's | 36 (17.39) | 18.2507 |
| 2000's | 79 (38.16) | 29.6817 |
| 2010's | 62 (29.95) | 24.3611 |
| 2020's | 15 (7.25) | 2.80 |
| Authors | Studies |
|---|---|
| Spiegelberg, J | 1 |
| Lederer, AK | 1 |
| Claus, S | 1 |
| Runkel, M | 1 |
| Utzolino, S | 1 |
| Fichtner-Feigl, S | 1 |
| Kousoulas, L | 1 |
| Han, SJ | 3 |
| Zhou, ZW | 3 |
| Yang, C | 3 |
| Wei, KP | 3 |
| Ma, JZ | 3 |
| Chu, ZF | 3 |
| Gu, P | 3 |
| Wang, LL | 1 |
| Tian, YM | 1 |
| Hu, S | 3 |
| Zhang, HP | 2 |
| Meng, XX | 1 |
| Zhong, YX | 2 |
| Du, MH | 1 |
| Ding, Y | 1 |
| Talbot, CT | 1 |
| Zersen, KM | 1 |
| Hess, AM | 1 |
| Hall, KE | 1 |
| Patel, N | 1 |
| Johnson, MA | 2 |
| Vapniarsky, N | 1 |
| Van Brocklin, MW | 1 |
| Williams, TK | 2 |
| Youngquist, ST | 1 |
| Ford, R | 1 |
| Ewer, N | 1 |
| Neff, LP | 2 |
| Hoareau, GL | 3 |
| Zhao, Y | 1 |
| Gao, J | 1 |
| Li, C | 1 |
| Song, G | 1 |
| Shan, Y | 1 |
| Haan, BJ | 1 |
| Cadiz, ML | 1 |
| Natavio, AM | 1 |
| Letson, HL | 1 |
| Granfeldt, A | 1 |
| Jensen, TH | 1 |
| Mattson, TH | 1 |
| Dobson, GP | 1 |
| Huh, Y | 1 |
| Ko, Y | 1 |
| Hwang, K | 1 |
| Jung, K | 1 |
| Cha, YH | 1 |
| Choi, YJ | 1 |
| Lee, J | 1 |
| Kim, JH | 1 |
| Levitt, DG | 1 |
| Levitt, JE | 1 |
| Levitt, MD | 1 |
| Canton, SP | 1 |
| Lutfi, W | 1 |
| Daley, BJ | 1 |
| Miller, RS | 1 |
| Harbrecht, BG | 2 |
| Claridge, JA | 2 |
| Phelan, HA | 1 |
| Guyette, FX | 1 |
| Sperry, JL | 1 |
| Brown, JB | 1 |
| Chance, TC | 1 |
| Wu, X | 1 |
| Keesee, JD | 1 |
| Garcia-Marcano, J | 1 |
| Salgado, CL | 1 |
| Liu, B | 1 |
| Moseley, JJ | 1 |
| Peck, KA | 1 |
| R-Borlado, L | 1 |
| Atai, NA | 1 |
| Gould, SJ | 1 |
| Marban, LS | 1 |
| Cap, AP | 1 |
| Rathbone, CR | 1 |
| Bynum, JA | 1 |
| Beni, CE | 1 |
| Arbabi, S | 1 |
| Robinson, BRH | 1 |
| O'Keefe, GE | 1 |
| Conner, J | 1 |
| Lammers, D | 1 |
| Holtestaul, T | 1 |
| Jones, I | 1 |
| Kuckelman, J | 1 |
| Letson, H | 1 |
| Dobson, G | 1 |
| Eckert, M | 1 |
| Bingham, J | 1 |
| Fligor, SC | 1 |
| Love, KM | 1 |
| Collier, BR | 1 |
| Lollar, DI | 1 |
| Hamill, ME | 1 |
| Benson, AD | 1 |
| Bradburn, EH | 1 |
| Slaughter, AL | 3 |
| Nunns, GR | 1 |
| D'Alessandro, A | 4 |
| Banerjee, A | 4 |
| Hansen, KC | 4 |
| Moore, EE | 4 |
| Silliman, CC | 4 |
| Nemkov, T | 3 |
| Moore, HB | 3 |
| Fragoso, M | 4 |
| Leasia, K | 1 |
| Peltz, ED | 2 |
| Müller, T | 1 |
| Kirsch, M | 1 |
| Petrat, F | 1 |
| Reisz, JA | 1 |
| Wither, MJ | 2 |
| Ghasabyan, A | 1 |
| Chandler, J | 1 |
| Schaub, LJ | 1 |
| Nunns, G | 1 |
| Sheppard, FR | 1 |
| Sun, W | 1 |
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| Qiu, W | 1 |
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| Ferreira, SADS | 1 |
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| Terzi, RGG | 1 |
| Ferreira, ELA | 1 |
| Silva, WA | 1 |
| Moreira, MM | 1 |
| Tibbits, EM | 1 |
| Simon, MA | 1 |
| Davidson, AJ | 1 |
| DeSoucy, ES | 1 |
| Faulconer, ER | 1 |
| Grayson, JK | 2 |
| Beyer, CA | 1 |
| Wilson, C | 1 |
| Kashtan, H | 1 |
| Wishy, A | 1 |
| Walker, L | 1 |
| Ross, JD | 2 |
| Stewart, IJ | 1 |
| Li, M | 1 |
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| Yu, B | 1 |
| Luo, Y | 1 |
| Li, Q | 2 |
| Wu, XQ | 1 |
| Li, ZB | 1 |
| Chen, WX | 1 |
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| Zhang, ZH | 1 |
| Xiong, XM | 1 |
| Markov, NP | 1 |
| Percival, TJ | 1 |
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| Scott, DJ | 1 |
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| Wu, MC | 1 |
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| Yen, ZS | 1 |
| Lee, CC | 1 |
| Chen, SC | 2 |
| Satterly, SA | 1 |
| Martin, M | 1 |
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| Hempel, J | 1 |
| Hoffer, Z | 1 |
| Stallings, JD | 1 |
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| Choi, JY | 2 |
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| Kim, SK | 1 |
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| Zhang, YM | 1 |
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| Sun, XD | 1 |
| Liu, XW | 1 |
| Bai, XD | 1 |
| Liu, XQ | 1 |
| Wang, HB | 1 |
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| Zhou, FQ | 2 |
| Carreira, S | 1 |
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| Lee, RP | 3 |
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| Soller, B | 2 |
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| Ellerby, GE | 1 |
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| Luo, L | 1 |
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| Zhang, ZZ | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Agreement Between Arterial, Central Venous, and Peripheral Venous Lactate in the Intensive Care Unit[NCT01624519] | 50 participants (Anticipated) | Interventional | 2012-08-31 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for lactic acid and Hemorrhagic Shock
| Article | Year |
|---|---|
Quantitative Assessment of Blood Lactate in Shock: Measure of Hypoxia or Beneficial Energy Source.
Topics: Animals; Critical Illness; Disease Models, Animal; Dogs; Humans; Hypoxia; Lactic Acid; Liver; Models | 2020 |
Trauma and aggressive homeostasis management.
Topics: Acidosis, Lactic; Brain Injuries; Homeostasis; Humans; Hyperglycemia; Hypothermia, Induced; Insulin; | 2013 |
Targeted resuscitation strategies after injury.
Topics: Acidosis; Algorithms; Humans; Hydrogen-Ion Concentration; Lactic Acid; Oxygen; Oxygen Consumption; R | 2004 |
Bench-to-bedside review: oxygen debt and its metabolic correlates as quantifiers of the severity of hemorrhagic and post-traumatic shock.
Topics: Acid-Base Equilibrium; Acidosis; Animals; Disease Models, Animal; Dogs; Humans; Hypovolemia; Hypoxia | 2005 |
Trauma and aggressive homeostasis management.
Topics: Acidosis; Animals; Brain Injuries; Homeostasis; Humans; Hyperglycemia; Hypothermia; Lactic Acid; Sho | 2007 |
5 trials available for lactic acid and Hemorrhagic Shock
197 other studies available for lactic acid and Hemorrhagic Shock
| Article | Year |
|---|---|
Severe hyperlactatemia in unselected surgical patients: retrospective analysis of prognostic outcome factors.
Topics: Humans; Hyperlactatemia; Lactic Acid; Prognosis; Retrospective Studies; Sepsis; Shock, Hemorrhagic | 2022 |
Study on an Animal Model of Seawater Immersion Injury Following Hemorrhagic Shock.
Topics: Animals; Disease Models, Animal; Hemorrhage; Lactic Acid; Male; Rats; Rats, Sprague-Dawley; Resuscit | 2023 |
Shock index is positively correlated with acute blood loss and negatively correlated with cardiac output in a canine hemorrhagic shock model.
Topics: Anesthesia, General; Animals; Cardiac Output; Dog Diseases; Dogs; Hemorrhage; Lactic Acid; Shock, He | 2023 |
Elamipretide mitigates ischemia-reperfusion injury in a swine model of hemorrhagic shock.
Topics: Animals; Balloon Occlusion; Disease Models, Animal; Endovascular Procedures; Hemorrhage; Lactic Acid | 2023 |
MILD THERAPEUTIC HYPOTHERMIA REDUCES ISCHEMIA-REPERFUSION INJURY AFTER ZONE 1 REBOA IN A SWINE HEMORRHAGIC SHOCK MODEL.
Topics: Animals; Aorta; Balloon Occlusion; Disease Models, Animal; Hypothermia; Hypothermia, Induced; Lactic | 2023 |
Efficacy and Safety of Vasopressin as First-Line Treatment of Distributive and Hemorrhagic Shock States.
Topics: Adult; Blood Pressure; Cohort Studies; Creatinine; Female; Heart Rate; Humans; Intensive Care Units; | 2020 |
Adenosine, Lidocaine, and Magnesium Support a High Flow, Hypotensive, Vasodilatory State With Improved Oxygen Delivery and Cerebral Protection in a Pig Model of Noncompressible Hemorrhage.
Topics: Adenosine; Animals; Brain; Brain Chemistry; Disease Models, Animal; Drug Administration Schedule; Dr | 2020 |
Admission Lactate and Base Deficit in Predicting Outcomes of Pediatric Trauma.
Topics: Adolescent; Child; Child, Preschool; Female; Hospitalization; Humans; Lactic Acid; Male; Predictive | 2021 |
Extracellular vesicles derived from cardiosphere-derived cells as a potential antishock therapeutic.
Topics: Animals; Blood Glucose; Creatinine; Disease Models, Animal; Extracellular Vesicles; Flow Cytometry; | 2021 |
Acute intensive care unit resuscitation of severely injured trauma patients: Do we need a new strategy?
Topics: Abbreviated Injury Scale; Acute Kidney Injury; Adult; Crystalloid Solutions; Duration of Therapy; Fe | 2021 |
Combatting ischemia reperfusion injury from resuscitative endovascular balloon occlusion of the aorta using adenosine, lidocaine and magnesium: A pilot study.
Topics: Adenosine; Animals; Anti-Inflammatory Agents; Aorta; Balloon Occlusion; Disease Models, Animal; Drug | 2021 |
Parathyroid hormone as a marker for hypoperfusion in trauma: A prospective observational study.
Topics: Adult; Aged; Biomarkers; Female; Follow-Up Studies; Humans; Lactic Acid; Male; Middle Aged; Parathyr | 2017 |
The Metabolopathy of Tissue Injury, Hemorrhagic Shock, and Resuscitation in a Rat Model.
Topics: Animals; Disease Models, Animal; Glycolysis; Hyperglycemia; Lactic Acid; Male; Metabolomics; Rats; R | 2018 |
Attenuation of Multiple Organ Damage by Continuous Low-Dose Solvent-Free Infusions of Resveratrol after Severe Hemorrhagic Shock in Rats.
Topics: Animals; Blood Glucose; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; He | 2017 |
All animals are equal but some animals are more equal than others: Plasma lactate and succinate in hemorrhagic shock-A comparison in rodents, swine, nonhuman primates, and injured patients.
Topics: Animals; Biomarkers; Chromatography, High Pressure Liquid; Disease Models, Animal; Gas Chromatograph | 2018 |
Application of pulsed arterial resuscitation in a rabbit model of hemorrhagic shock.
Topics: Animals; Blood Pressure; Disease Models, Animal; Heart Rate; Lactic Acid; Rabbits; Random Allocation | 2017 |
A fatal and metabolic experimental hemorrhagic shock in immature swine.
Topics: Animals; Biomarkers; Control Groups; Disease Models, Animal; Endpoint Determination; Hemodynamics; H | 2017 |
Endovascular variable aortic control (EVAC) versus resuscitative endovascular balloon occlusion of the aorta (REBOA) in a swine model of hemorrhage and ischemia reperfusion injury.
Topics: Animals; Aorta; Balloon Occlusion; Disease Models, Animal; Endovascular Procedures; Female; Hemodyna | 2018 |
Extracorporeal potassium binding for the management of hyperkalemia in an anephric model of crush injury.
Topics: Animals; Crush Injuries; Disease Models, Animal; Extracorporeal Circulation; Female; Hyperkalemia; K | 2019 |
Activation of Hypoxia-Inducible Factor-1α Via Succinate Dehydrogenase Pathway During Acute Lung Injury Induced by Trauma/Hemorrhagic Shock.
Topics: A549 Cells; Acute Lung Injury; Animals; Blood Gas Analysis; Blotting, Western; Humans; Hypoxia-Induc | 2020 |
The influence of different resuscitation solution on lactic acid accumulation after hemorrhagic shock: a network meta-analysis.
Topics: Colloids; Crystalloid Solutions; Fluid Therapy; Humans; Lactic Acid; Network Meta-Analysis; Plasma S | 2019 |
Physiologic tolerance of descending thoracic aortic balloon occlusion in a swine model of hemorrhagic shock.
Topics: Animals; Aorta, Thoracic; Balloon Occlusion; Blood Pressure; Blood Transfusion; Disease Models, Anim | 2013 |
Target blood pressure for hypotensive resuscitation.
Topics: Animals; Cytokines; Disease Models, Animal; Fluid Therapy; Hematocrit; Hypotension; Isotonic Solutio | 2013 |
Flutamide fails to reduce resuscitation requirements in a porcine ischemia-reperfusion model.
Topics: Acidosis; Androgen Antagonists; Animals; Crystalloid Solutions; Cyclodextrins; Disease Models, Anima | 2013 |
Mortality prediction of rats in acute hemorrhagic shock using machine learning techniques.
Topics: Animals; Artificial Intelligence; Body Temperature; Hemodynamics; Lactic Acid; Logistic Models; Male | 2013 |
Effect of Hypotensive Resuscitation with a Novel Combination of Fluids in a Rabbit Model of Uncontrolled Hemorrhagic Shock.
Topics: Animals; Blood Gas Analysis; Blood Pressure; Disease Models, Animal; Fluid Therapy; Hemodynamics; Hy | 2013 |
Pyruvate Ringer's solution corrects lactic acidosis and prolongs survival during hemorrhagic shock in rats.
Topics: Acidosis, Lactic; Analysis of Variance; Animals; Arterial Pressure; Carbon Dioxide; Disease Models, | 2013 |
Diaphragmatic function is preserved during severe hemorrhagic shock in the rat.
Topics: Animals; Arterial Pressure; Blood Gas Analysis; Cytokines; Diaphragm; Fluid Therapy; Lactic Acid; Ma | 2014 |
Deleterious effects of aggressive rapid crystalloid resuscitation on treatment of hyperinflammatory response and lung injury induced by hemorrhage in aging rats.
Topics: Acute Lung Injury; Aging; Animals; Blood Glucose; Blood Pressure; Body Temperature; Bronchoalveolar | 2014 |
A proposed novel algorithmic approach to the evaluation of the acutely injured trauma patient: should advanced trauma life support incorporate biomarkers?
Topics: Advanced Trauma Life Support Care; Algorithms; Biomarkers; Carbon Dioxide; Decision Support Techniqu | 2014 |
[Lactic acid as a prognostic marker in obstetric postpartum hemorrhage].
Topics: Acute Kidney Injury; Adult; Biomarkers; Cesarean Section; Disseminated Intravascular Coagulation; Fe | 2014 |
Blood pressure-targeted stepwise resuscitation for hemorrhagic shock in rats.
Topics: Alanine Transaminase; Animals; Blood Gas Analysis; Blood Pressure; Interleukin-1beta; Interleukin-6; | 2014 |
Investigation of noninvasive muscle pH and oxygen saturation during uncontrolled hemorrhage and resuscitation in swine.
Topics: Acidosis; Animals; Biomarkers; Female; Fluid Therapy; Hemodynamics; Hydrogen-Ion Concentration; Lact | 2014 |
The noninvasive carbon dioxide gradient (NICO2G) during hemorrhagic shock.
Topics: Animals; Biomarkers; Blood Gas Monitoring, Transcutaneous; Breath Tests; Capnography; Carbon Dioxide | 2014 |
Mesenteric lymph drainage alleviates acute kidney injury induced by hemorrhagic shock without resuscitation.
Topics: 2,3-Diphosphoglycerate; Acute Kidney Injury; Animals; Biomarkers; Disease Models, Animal; Drainage; | 2014 |
Utilization of extracorporeal membrane oxygenation alleviates intestinal ischemia-reperfusion injury in prolonged hemorrhagic shock animal model.
Topics: Animals; Blood Pressure; Claudin-1; Disease Models, Animal; Extracorporeal Membrane Oxygenation; Int | 2014 |
Protection against intestinal injury from hemorrhagic shock by direct peritoneal resuscitation with pyruvate in rats.
Topics: Animals; Dialysis Solutions; Drug Evaluation, Preclinical; Fluid Therapy; Inflammation Mediators; In | 2014 |
Effects of pyruvate-enriched peritoneal dialysis solution on intestinal barrier in peritoneal resuscitation from hemorrhagic shock in rats.
Topics: Animals; Blood Pressure; Cell Adhesion Molecules; Dialysis Solutions; Disease Models, Animal; Intest | 2015 |
A novel nanobiotherapeutic poly-[hemoglobin-superoxide dismutase-catalase-carbonic anhydrase] with no cardiac toxicity for the resuscitation of a rat model with 90 minutes of sustained severe hemorrhagic shock with loss of 2/3 blood volume.
Topics: Animals; Biological Transport; Blood Pressure; Blood Substitutes; Blood Volume; Carbon Dioxide; Carb | 2015 |
Hypertension and vulnerability to hemorrhagic shock in a rat model.
Topics: Animals; Blood Pressure; Hemodynamics; Hypertension; Lactic Acid; Male; Muscle, Skeletal; Oxygen Con | 2015 |
Effects of intraosseous erythropoietin during hemorrhagic shock in swine.
Topics: Animals; Cytokines; Disease Models, Animal; Erythropoietin; Heart; Hemodynamics; Infusions, Intraoss | 2014 |
Comparison of Noninvasive pH and Blood Lactate as Predictors of Mortality in a Swine Hemorrhagic Shock with Restricted Volume Resuscitation Model.
Topics: Animals; Area Under Curve; Disease Models, Animal; Hemorrhage; Hydrogen-Ion Concentration; Lactic Ac | 2015 |
Tissue ischemia microdialysis assessments following severe traumatic haemorrhagic shock: lactate/pyruvate ratio as a new resuscitation end point?
Topics: Adult; Cardiac Output; Female; Hemoglobins; Humans; Lactic Acid; Male; Microdialysis; Middle Aged; O | 2014 |
Beneficial effect of cyclosporine A on traumatic hemorrhagic shock.
Topics: Animals; Cyclosporine; Cytokines; Female; Hemodynamics; Hydrogen-Ion Concentration; Kidney; Lactic A | 2015 |
Hextend-perfluorocarbon cocktail inhibits mean arterial pressure response in a rabbit shock model.
Topics: Acidosis, Lactic; Animals; Blood Pressure; Blood Substitutes; Disease Models, Animal; Drug Evaluatio | 2015 |
Protective effects of polyethylene oxide on the vascular and organ function of rats with severe hemorrhagic shock.
Topics: Animals; Biomarkers; Disease Models, Animal; Fluid Therapy; Hemodynamics; Inflammation Mediators; In | 2015 |
Comparison of Malated Ringer's with Two Other Balanced Crystalloid Solutions in Resuscitation of Both Severe and Moderate Hemorrhagic Shock in Rats.
Topics: Acidosis; Animals; Crystalloid Solutions; Disease Models, Animal; Humans; Isotonic Solutions; Lactic | 2015 |
Trauma/hemorrhagic shock instigates aberrant metabolic flux through glycolytic pathways, as revealed by preliminary (13)C-glucose labeling metabolomics.
Topics: Animals; Carbon; Glycolysis; Isotope Labeling; Lactic Acid; Metabolic Flux Analysis; Metabolomics; R | 2015 |
Inhaled Carbon Monoxide Protects against the Development of Shock and Mitochondrial Injury following Hemorrhage and Resuscitation.
Topics: Adenosine Triphosphate; Administration, Inhalation; Animals; Carbon Monoxide; Cells, Cultured; Inter | 2015 |
Biliary tract external drainage protects against intestinal barrier injury in hemorrhagic shock rats.
Topics: Animals; Biliary Tract Surgical Procedures; Biomarkers; Blotting, Western; Claudin-1; Disease Models | 2015 |
Plasma First Resuscitation Reduces Lactate Acidosis, Enhances Redox Homeostasis, Amino Acid and Purine Catabolism in a Rat Model of Profound Hemorrhagic Shock.
Topics: Acidosis; Amino Acids; Animals; Crystalloid Solutions; Fluid Therapy; Isotonic Solutions; Lactic Aci | 2016 |
Vascular smooth muscle desensitization in rabbit epigastric and mesenteric arteries during hemorrhagic shock.
Topics: Animals; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP-Dependent Protein Kinases; Disease Models, | 2016 |
Clinical study of a new Modified Early Warning System scoring system for rapidly evaluating shock in adults.
Topics: Adult; Aged; APACHE; Area Under Curve; Arterial Pressure; Biomedical Research; Early Diagnosis; Emer | 2017 |
A comparison of initial lactate and initial base deficit as predictors of mortality after severe blunt trauma.
Topics: Acidosis; Adult; Aged; Biomarkers; Female; Hospital Mortality; Humans; Lactic Acid; Logistic Models; | 2016 |
Neurochemical changes following combined hypoxemia and hemorrhagic shock in a rat model of penetrating ballistic-like brain injury: A microdialysis study.
Topics: Animals; Brain; Disease Models, Animal; Glucose; Head Injuries, Penetrating; Hypoxia; Lactic Acid; M | 2016 |
The role of bicarbonate precursors in balanced fluids during haemorrhagic shock with and without compromised liver function.
Topics: Acetates; Acid-Base Equilibrium; Animals; Bicarbonates; Fluid Therapy; Kidney; Lactic Acid; Liver; M | 2016 |
Lactate profiles as a resuscitation assessment tool in a rat model of battlefield hemorrhage resuscitation.
Topics: Animals; Disease Models, Animal; Hemoglobins; Hydroxyethyl Starch Derivatives; Lactic Acid; Male; Ra | 2008 |
Albumin resuscitation protects against traumatic/hemorrhagic shock-induced lung apoptosis in rats.
Topics: Albumins; Animals; Apoptosis; Enzyme Activation; Immunohistochemistry; In Situ Nick-End Labeling; La | 2008 |
Management of hemorrhagic shock when blood is not an option.
Topics: Blood Substitutes; Hemoglobins; Humans; Jehovah's Witnesses; Lactic Acid; Male; Multiple Trauma; Sho | 2008 |
Accurate and continuous measurement of oxygen deficit during haemorrhage in pigs.
Topics: Animals; Blood Glucose; Blood Pressure; Blood Volume; Calorimetry, Indirect; Cardiac Output; Heart R | 2009 |
Role of extracellular signal-regulated protein kinase (ERK) in 17beta-estradiol-mediated attenuation of lung injury after trauma-hemorrhage.
Topics: Acute Lung Injury; Animals; Biomarkers; Chemokine CXCL1; Chemokine CXCL2; Down-Regulation; Estradiol | 2009 |
Effects of different fluid resuscitation speeds on blood glucose and interleukin-1 beta in hemorrhagic shock.
Topics: Animals; Blood Glucose; Blood Pressure; Fluid Therapy; Heart Rate; Hematocrit; Hemoglobinometry; Int | 2009 |
Fluid resuscitation does not improve renal oxygenation during hemorrhagic shock in rats.
Topics: Animals; Blood Pressure; Blood Transfusion; Fluid Therapy; Hemodynamics; Inflammation; Kidney; Kidne | 2010 |
Correlation between arterial and capillary lactate measurements in a porcine hemorrhagic shock model.
Topics: Animals; Arteries; Blood Chemical Analysis; Capillaries; Lactic Acid; Shock, Hemorrhagic; Swine | 2010 |
The cerebral microcirculation is protected during experimental hemorrhagic shock.
Topics: Animals; Blood Flow Velocity; Blood Gas Analysis; Blood Pressure; Blood Volume; Brain; Brain Ischemi | 2010 |
Utility of microdialysis to detect the lactate/pyruvate ratio in subcutaneous tissue for the reliable monitoring of hemorrhagic shock.
Topics: Animals; Blood Pressure; Early Diagnosis; Hypotension; Lactic Acid; Male; Microdialysis; Monitoring, | 2009 |
Diaspirin cross-linked hemoglobin infusion did not influence base deficit and lactic acid levels in two clinical trials of traumatic hemorrhagic shock patient resuscitation.
Topics: Acidosis, Lactic; Adult; Aspirin; Emergency Medical Services; Emergency Treatment; Europe; Fluid The | 2010 |
Moderate Ringer's lactate solution resuscitation yields best neurological outcome in controlled hemorrhagic shock combined with brain injury in rats.
Topics: Animals; Brain; Brain Injuries; Isotonic Solutions; Lactic Acid; Male; Rats; Rats, Inbred Lew; Ringe | 2010 |
The effects of 6% hydroxyethyl starch-hypertonic saline in resuscitation of dogs with hemorrhagic shock.
Topics: Acid-Base Equilibrium; Animals; Blood Pressure; Blood Volume; Carbon Dioxide; Disease Models, Animal | 2011 |
Liver X receptor α activation with the synthetic ligand T0901317 reduces lung injury and inflammation after hemorrhage and resuscitation via inhibition of the nuclear factor κB pathway.
Topics: Animals; Bicarbonates; Chemokine CCL2; Chemokine CCL3; Cholesterol; Disease Models, Animal; Hydrocar | 2011 |
Cardiopulmonary effects of hemorrhagic shock in splenic autotransplanted pigs: a new surgical model.
Topics: Animals; Body Temperature; Female; Hemodynamics; Lactic Acid; Male; Models, Animal; Shock, Hemorrhag | 2010 |
Prospective identification of patients at risk for massive transfusion: an imprecise endeavor.
Topics: Adult; Blood Pressure; Blood Transfusion; Emergency Service, Hospital; Erythrocyte Transfusion; Hear | 2011 |
A model of hemorrhagic shock and acute lung injury in Landrace-Large White Swine.
Topics: Acute Lung Injury; Animals; Disease Models, Animal; Heart Rate; Hemoglobins; Hydrogen-Ion Concentrat | 2011 |
Correlation between IVC dimensions and volume status on CT scan.
Topics: Adult; Aged; Blood Volume; Blood Volume Determination; Databases, Factual; Female; Humans; Lactic Ac | 2011 |
Tissue gas tensions and tissue metabolites for detection of organ hypoperfusion and ischemia.
Topics: Aerobiosis; Anaerobiosis; Animals; Area Under Curve; Bicarbonates; Blood Pressure; Body Temperature; | 2012 |
Therapeutic effects of intravenous infusion of hyperoxygenated solution on acute haemorrhagic shock in rabbits.
Topics: Animals; Blood Pressure; Blood Viscosity; Blood Volume; Hydrogen-Ion Concentration; Infusions, Intra | 2011 |
Increased circulating D-lactate levels predict risk of mortality after hemorrhage and surgical trauma in baboons.
Topics: Animals; Colon; Disease Models, Animal; Humans; Ischemia; Lactic Acid; Male; Papio ursinus; Risk Fac | 2012 |
Physiologic responses to severe hemorrhagic shock and the genesis of cardiovascular collapse: can irreversibility be anticipated?
Topics: Animals; Autonomic Nervous System; Blood Pressure; Catecholamines; Cytokines; Disease Models, Animal | 2012 |
Triage vital signs do not correlate with serum lactate or base deficit, and are less predictive of operative intervention in penetrating trauma patients: a prospective cohort study.
Topics: Adult; Biomarkers; Cohort Studies; Emergency Service, Hospital; Female; Humans; Lactic Acid; Linear | 2013 |
A new severity predicting index for hemorrhagic shock using lactate concentration and peripheral perfusion in a rat model.
Topics: Animals; Blood Pressure; Heart Rate; Lactic Acid; Male; Microcirculation; Perfusion; Predictive Valu | 2012 |
Intestinal preconditioning prevents systemic inflammatory response in hemorrhagic shock. Role of HO-1.
Topics: Animals; Fluid Therapy; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Inflammation; Intestines; Is | 2002 |
Pyruvate improves redox status and decreases indicators of hepatic apoptosis during hemorrhagic shock in swine.
Topics: Acid-Base Equilibrium; Animals; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Blood Pressure | 2002 |
Low-dose ethanol alters the cardiovascular, metabolic, and respiratory compensation for severe blood loss.
Topics: Alcoholic Intoxication; Animals; Blood Glucose; Blood Pressure; Carbon Dioxide; Disease Models, Anim | 2002 |
Detrimental effects of rapid fluid resuscitation on hepatocellular function and survival after hemorrhagic shock.
Topics: Animals; Creatinine; Fluid Therapy; Hepatocytes; Infusions, Intravenous; Lactic Acid; Liver; Male; O | 2002 |
Effects of hypertonic saline and dextran 70 on cardiac diastolic function after hemorrhagic shock.
Topics: Animals; Blood Pressure; Blood Volume; Diastole; Gases; Heart; Hemodynamics; Hydrogen-Ion Concentrat | 2002 |
Increased skeletal muscle lactate production following hemorrhagic shock in rats.
Topics: Animals; Cell Membrane Permeability; Hypoxia; Lactic Acid; Muscle, Skeletal; Rats; Shock, Hemorrhagi | 2002 |
A comparison of lactated ringer's solution to hydroxyethyl starch 6% in a model of severe hemorrhagic shock and continuous bleeding in dogs.
Topics: Animals; Blood Loss, Surgical; Blood Pressure; Dogs; Hemodynamics; Hemorrhage; Hydroxyethyl Starch D | 2003 |
Preservation of neurological functions by nitric oxide synthase inhibitors following hemorrhagic shock.
Topics: Animals; Aspartate Aminotransferases; Avoidance Learning; Blood Pressure; Canavanine; Cerebral Corte | 2003 |
Resuscitation with a novel hemoglobin-based oxygen carrier in a Swine model of uncontrolled perioperative hemorrhage.
Topics: Animals; Blood Cell Count; Blood Loss, Surgical; Disease Models, Animal; Electroencephalography; Hem | 2003 |
Effect of a delta receptor agonist on duration of survival during hemorrhagic shock.
Topics: Animals; Enkephalin, Leucine-2-Alanine; Hemodynamics; Lactic Acid; Rats; Rats, Sprague-Dawley; Recep | 2003 |
Hypertonic saline improves tissue oxygenation and reduces systemic and pulmonary inflammatory response caused by hemorrhagic shock.
Topics: Animals; Blood Gas Analysis; Blood Pressure; Dose-Response Relationship, Drug; Fluid Therapy; Inflam | 2003 |
Protective effect of urinary trypsin inhibitor on myocardial mitochondria during hemorrhagic shock and reperfusion.
Topics: Adenosine Triphosphate; Animals; Blood Pressure; Blood Transfusion, Autologous; Energy Metabolism; G | 2003 |
The influence of hemorrhagic shock on propofol: a pharmacokinetic and pharmacodynamic analysis.
Topics: Algorithms; Analysis of Variance; Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Ani | 2003 |
Increased plasma D-lactate is associated with the severity of hemorrhagic/traumatic shock in rats.
Topics: Animals; Blood Pressure; Body Weight; Endotoxins; Hydrogen-Ion Concentration; Lactic Acid; Male; Pre | 2003 |
Effects of hypertonic saline, HAES and dimethylsulphoxide on free oxygen radicals in haemorrhagic shock oxygen radicals in haemorrhagic shock.
Topics: Animals; Dimethyl Sulfoxide; Disease Models, Animal; Erythrocytes; Free Radical Scavengers; Infusion | 2003 |
EXCESS LACTATE: AN INDEX OF REVERSIBILITY OF SHOCK IN HUMAN PATIENTS.
Topics: Animals; Blood Chemical Analysis; Dogs; Humans; Hypoxia; Lactates; Lactic Acid; Metabolism; Oxygen; | 1964 |
LACTICACIDOSIS: A CLINICALLY SIGNIFICANT ASPECT OF SHOCK.
Topics: Acidosis; Bicarbonates; Blood Chemical Analysis; Female; Humans; Lactates; Lactic Acid; Myocardial I | 1964 |
Complement activation during hemorrhagic shock and resuscitation in swine.
Topics: Acidosis, Lactic; Animals; Complement Activation; Complement C5a; Complement System Proteins; In Vit | 2003 |
Improved survival in uncontrolled hemorrhagic shock induced by massive splenic injury in the proestrus phase of the reproductive cycle in the female rat.
Topics: Animals; Blood Pressure; Estradiol; Estrous Cycle; Female; Heart Rate; Hematocrit; Lactic Acid; Male | 2003 |
Tissue energetics as measured by nuclear magnetic resonance spectroscopy during hemorrhagic shock.
Topics: Adenosine Triphosphate; Animals; Blood Pressure; Gastric Mucosa; Lactic Acid; Liver; Magnetic Resona | 2004 |
Splanchnic metabolism during gut ischemia and short-term endotoxin and hemorrhagic shock as evaluated by intravasal microdialysis.
Topics: Abdomen; Animals; Endotoxemia; Endotoxins; Glucose; Glycerol; Hemodynamics; Ileum; Ischemia; Lactic | 2004 |
Can we distinguish between different types of local perfusion/metabolic derangement by regional venous concentrations of intermediary energy substrates?
Topics: Animals; Endotoxins; Glucose; Glycerol; Lactic Acid; Microdialysis; Perfusion; Pyruvic Acid; Reperfu | 2004 |
Diagnostic utility of sublingual PCO2 for detecting hemorrhage in penetrating trauma patients.
Topics: Adult; Baltimore; Blood Gas Monitoring, Transcutaneous; Carbon Dioxide; Female; Humans; Lactic Acid; | 2004 |
Methylene blue enhancement of resuscitation after refractory hemorrhagic shock.
Topics: Animals; Blood Pressure; Dogs; Lactic Acid; Methylene Blue; Resuscitation; Shock, Hemorrhagic | 2004 |
Strong ion gap.
Topics: Acid-Base Equilibrium; Acute Kidney Injury; Adult; Blood Vessels; Critical Care; Hospital Mortality; | 2005 |
Adrenomedullin and its binding protein attenuate the proinflammatory response after hemorrhage.
Topics: Adrenomedullin; Alanine Transaminase; Animals; Aspartate Aminotransferases; Complement Factor H; Cre | 2005 |
[Effects of Astragalus membranaceus injection on nitric oxide and endothelin concentration of intestinal mucosa after hemorrhage shock-reperfusion in rats].
Topics: Animals; Astragalus propinquus; Drugs, Chinese Herbal; Endothelins; Ileum; Injections, Intravenous; | 2004 |
Increases in both buccal and sublingual partial pressure of carbon dioxide reflect decreases of tissue blood flows in a porcine model during hemorrhagic shock.
Topics: Animals; Blood Pressure; Carbon Dioxide; Cardiac Output; Cheek; Disease Models, Animal; Kidney; Lact | 2005 |
Effects of three fluid resuscitation methods on apoptosis of visceral organs in rats with hemorrhagic shock.
Topics: Animals; Apoptosis; Blood Pressure; Flow Cytometry; Fluid Therapy; In Situ Nick-End Labeling; Intest | 2005 |
The physiological changes of cumulative hemorrhagic shock in conscious rats.
Topics: Anesthesia; Animals; Blood Pressure; Consciousness; Cytokines; Disease Models, Animal; Heart Rate; I | 2006 |
24-hour pretreatment with delta opioid enhances survival from hemorrhagic shock.
Topics: Animals; Blood Pressure; Disease Models, Animal; Heart Rate; Ischemic Preconditioning; Lactic Acid; | 2006 |
Effects of candesartan and enalaprilat on the organ-specific microvascular permeability during haemorrhagic shock in rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimid | 2006 |
Impact of vasopressin on hemodynamic and metabolic function in the decompensatory phase of hemorrhagic shock.
Topics: Animals; Blood Pressure; Disease Models, Animal; Female; Hydrogen-Ion Concentration; Lactic Acid; Ma | 2006 |
Early difference in apoptosis of intestinal mucosa of rats with severe uncontrolled hemorrhagic shock after three fluid resuscitation methods.
Topics: Animals; Apoptosis; Blood Pressure; Disease Models, Animal; Flow Cytometry; Fluid Therapy; In Situ N | 2006 |
Resuscitation of severe but brief haemorrhagic shock with PFC in rabbits restores skeletal muscle oxygen delivery and does not alter skeletal muscle metabolism.
Topics: Animals; Blood Pressure; Blood Substitutes; Disease Models, Animal; Fluorocarbons; Hyperoxia; Lactic | 2006 |
[Blood lactate concentrations as predictors of outcome in serious hemorrhagic shock patients].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Disseminated Intravascular Coagulation; Forecasting; Hum | 2006 |
Bovine polymerized hemoglobin versus Hextend resuscitation in a swine model of severe controlled hemorrhagic shock with delay to definitive care.
Topics: Animals; Blood Pressure; Blood Substitutes; Body Temperature; Cattle; Disease Models, Animal; Female | 2006 |
Hemodynamic effects of combined treatment with oxygen and hypertonic saline in hemorrhagic shock.
Topics: Analysis of Variance; Animals; Blood Pressure; Cardiac Output; Combined Modality Therapy; Fluid Ther | 2006 |
Major hepatic trauma: warm ischemic tolerance of the liver after hemorrhagic shock.
Topics: Acute Disease; Acute-Phase Reaction; Animals; Aspartate Aminotransferases; Biopsy; Creatinine; Hot T | 2006 |
Downregulation of hepatic cytochrome P-450 isoforms and PPAR-gamma: their role in hepatic injury and proinflammatory responses in a double-hit model of hemorrhage and sepsis.
Topics: Alanine Transaminase; Animals; Aryl Hydrocarbon Hydroxylases; Aspartate Aminotransferases; Cytochrom | 2007 |
Fluid resuscitation with hemoglobin-vesicle solution does not increase hypoxia or inflammatory responses in moderate hemorrhagic shock.
Topics: Animals; Blood Pressure; Blood Substitutes; Hemoglobins; Hypoxia; Inflammation; Isotonic Solutions; | 2006 |
Sublingual capnometry for rapid determination of the severity of hemorrhagic shock.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analysis of Variance; Blood Gas Monitoring, Transcutaneo | 2007 |
Hypertonic 15% sodium pyruvate offers no initial resuscitation advantage compared with 8% hypertonic NACl in sheep with multiple hemorrhages.
Topics: Animals; Blood Pressure; Female; Fluid Therapy; Hypertonic Solutions; Lactic Acid; Plasma Volume; Py | 2007 |
Physiologic response to hemorrhagic shock depends on rate and means of hemorrhage.
Topics: Animals; Blood Pressure; Disease Models, Animal; Heart Rate; Isotonic Solutions; Lactic Acid; Male; | 2007 |
Post-treatment with the novel deltorphin E, a delta2-opioid receptor agonist, increases recovery and survival after severe hemorrhagic shock in behaving rats.
Topics: Animals; Blood Pressure; Heart Rate; Lactic Acid; Oligopeptides; Rats; Receptors, Opioid, delta; Sho | 2008 |
The first demonstration of lactic acid in human blood in shock by Johann Joseph Scherer (1814-1869) in January 1843.
Topics: Germany; History, 19th Century; Humans; Lactic Acid; Leukemia; Male; Shock, Hemorrhagic | 2007 |
Evaluating tissue perfusion using labelled water indicator microdialysis in a rat model of haemorrhagic shock.
Topics: Animals; Blood Pressure; Disease Models, Animal; Lactic Acid; Liver; Male; Microdialysis; Muscle, Sk | 2007 |
Resuscitation from hemorrhagic shock comparing standard hemoglobin-based oxygen carrier (HBOC)-201 versus 7.5% hypertonic HBOC-201.
Topics: Animals; Biomarkers; Blood Substitutes; Disease Models, Animal; Dose-Response Relationship, Drug; He | 2007 |
Experimental study of controlled fluid resuscitation in the treatment of severe and uncontrolled hemorrhagic shock.
Topics: Animals; Apoptosis; Blood Pressure; Disease Models, Animal; Fluid Therapy; Hematocrit; Hemoglobins; | 2007 |
[Hemorrheological changes in irreversible hemorrhagic shock].
Topics: Animals; Blood Viscosity; Disease Models, Animal; Erythrocyte Aggregation; Erythrocyte Deformability | 2008 |
The utility of base deficit and arterial lactate in differentiating major from minor injury in trauma patients with normal vital signs.
Topics: Acid-Base Imbalance; Adolescent; Adult; Aged; Aged, 80 and over; Bicarbonates; Female; Humans; Injur | 2008 |
Human vasoactive hormone adrenomedullin and its binding protein rescue experimental animals from shock.
Topics: Adrenomedullin; Alanine Transaminase; Animals; Aspartate Aminotransferases; Complement Factor H; Cre | 2008 |
Mechanism of estrogen-mediated intestinal protection following trauma-hemorrhage: p38 MAPK-dependent upregulation of HO-1.
Topics: Animals; Chemokine CXCL1; Chemokine CXCL2; Estrogens; Heme Oxygenase-1; Hemorrhage; Intercellular Ad | 2008 |
Reproducibility of an animal model simulating complex combat-related injury in a multiple-institution format.
Topics: Acidosis; Animals; Blood Gas Analysis; Disease Models, Animal; Femoral Fractures; Hematocrit; Hemody | 2009 |
[Effects of methylene blue on refractory hemorrhagic shock].
Topics: Animals; Blood Pressure; Disease Models, Animal; Female; Interleukin-6; Interleukin-8; Lactic Acid; | 2008 |
Mechanism of functional residual capacity increase in haemorrhagic shock.
Topics: Abdominal Muscles; Animals; Dogs; Electromyography; Functional Residual Capacity; Intercostal Muscle | 1983 |
[Metabolic effects of crystalloids and colloids in resuscitation of experimental hemorrhagic shock].
Topics: Animals; Colloids; Dogs; Fluid Therapy; Lactates; Lactic Acid; Plasma Volume; Resuscitation; Shock, | 1983 |
Lactate generation by liver in hemorrhagic shock.
Topics: Animals; Carbon Dioxide; Dogs; Hydrogen-Ion Concentration; Kinetics; Lactates; Lactic Acid; Liver; O | 1981 |
Liver adenosine triphosphate (ATP) in hypoxia and hemorrhagic shock.
Topics: Acidosis, Respiratory; Adenosine Triphosphate; Animals; Arteries; Hydrogen-Ion Concentration; Hypoxi | 1982 |
The effect of pH of resuscitative fluids in treatment of severe hemorrhagic shock.
Topics: Animals; Dogs; Fluid Therapy; Hemodynamics; Hydrogen-Ion Concentration; Lactates; Lactic Acid; Pulmo | 1981 |
Vascular and metabolic effects of methylprednisolone and phenoxybenzamine during controlled hypotension in the dog.
Topics: Animals; Dogs; Hydrogen-Ion Concentration; Hypotension, Controlled; Lactates; Lactic Acid; Male; Met | 1981 |
Hypertonic saline-dextran resuscitation from hemorrhagic shock induces transient mixed acidosis.
Topics: Acid-Base Equilibrium; Acidosis; Animals; Dextrans; Electrolytes; Female; Fluid Therapy; Hemodynamic | 1995 |
Beneficial effects of antioxidants in hemorrhagic shock.
Topics: Analysis of Variance; Animals; Antioxidants; Creatine Kinase; Dogs; Female; Hemodynamics; Lactates; | 1995 |
Role of oxyradicals in cardiovascular depression and cellular injury in hemorrhagic shock and reinfusion: effect of SOD and catalase.
Topics: Animals; Catalase; Creatine Kinase; Dogs; Female; Free Radicals; Hemodynamics; Lactates; Lactic Acid | 1994 |
Improved myocardial function using cardiopulmonary support in resuscitation for hemorrhagic shock.
Topics: Animals; Cardiopulmonary Resuscitation; Coronary Circulation; Hemodynamics; Lactates; Lactic Acid; M | 1994 |
The relationship of base deficit to lactate in porcine hemorrhagic shock and resuscitation.
Topics: Acidosis; Animals; Disease Models, Animal; Hemodynamics; Lactates; Lactic Acid; Oxygen; Oxygen Consu | 1994 |
Redox state in liver mitochondria in acute copper sulfate poisoning.
Topics: 3-Hydroxybutyric Acid; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Copper; Copper Sulf | 1994 |
Role of xanthine oxidase inhibition in survival from hemorrhagic shock.
Topics: Allopurinol; Animals; Dogs; Free Radical Scavengers; Lactates; Lactic Acid; Shock, Hemorrhagic; Surv | 1994 |
Diltiazem preserves hepatic gluconeogenesis following hemorrhagic shock.
Topics: Animals; Diltiazem; Disease Models, Animal; Gluconeogenesis; Glucose; Isotonic Solutions; Lactates; | 1993 |
A comparison of the effects of skeletal muscle injury and somatic afferent nerve stimulation on the response to hemorrhage in anesthetized pigs.
Topics: Anesthesia; Animals; Blood Pressure; Brachial Plexus; Electric Stimulation; Heart Rate; Hemodynamics | 1993 |
Lactated Ringer's solution alleviates brain trauma-precipitated lactic acidosis in hemorrhagic shock.
Topics: Acidosis, Lactic; Animals; Blood Glucose; Brain Injuries; Cerebral Hemorrhage; Gases; Hydrogen-Ion C | 1993 |
Interleukin-1 receptor antagonist improves survival and preserves organ adenosine-5'-triphosphate after hemorrhagic shock.
Topics: Adenosine Triphosphate; Animals; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Lactates; | 1993 |
PCO2 electrodes at the surface of the kidney detect ischaemia.
Topics: Animals; Carbon Dioxide; Cardiac Output; Electrodes; Hydrogen-Ion Concentration; Ischemia; Kidney; L | 1996 |
Use of recombinant hemoglobin solution in reversing lethal hemorrhagic hypovolemic oxygen debt shock.
Topics: Animals; Blood Pressure; Blood Substitutes; Cardiac Output; Dogs; Heart Rate; Hemoglobins; Intestine | 1997 |
Activation of pyruvate dehydrogenase improves heart function and metabolism after hemorrhagic shock.
Topics: Adenosine Triphosphate; Animals; Arteries; Blood Chemical Analysis; Blood Pressure; Dichloroacetic A | 1997 |
Cardiac depression and cellular injury in hemorrhagic shock and reinfusion: role of free radicals.
Topics: Animals; Catalase; Creatine Kinase; Dogs; Female; Free Radicals; Glutathione Peroxidase; Hemodynamic | 1997 |
End-tidal partial pressure of carbon dioxide as a noninvasive indicator of systemic oxygen supply dependency during hemorrhagic shock and resuscitation.
Topics: Animals; Blood Transfusion; Carbon Dioxide; Dogs; Hemodynamics; Lactic Acid; Oxygen; Oxygen Consumpt | 1997 |
Inhibition of nitric oxide synthesis aggravates myocardial ischemia in hemorrhagic shock in constant pressure model.
Topics: Adenosine Triphosphate; Animals; Aorta; Catecholamines; Disease Models, Animal; Dogs; Enzyme Inhibit | 1998 |
Increased skeletal muscle Na+, K+-ATPase activity as a cause of increased lactate production after hemorrhagic shock.
Topics: Animals; Enzyme Inhibitors; Glycogen; Lactic Acid; Male; Muscle, Skeletal; Organ Culture Techniques; | 1998 |
Sublingual capnometry for diagnosis and quantitation of circulatory shock.
Topics: Animals; Biomarkers; Capnography; Hemodynamics; Lactic Acid; Rats; Rats, Sprague-Dawley; Shock, Hemo | 1998 |
Utility of clinical parameters of tissue oxygenation in a quantitative model of irreversible hemorrhagic shock.
Topics: Animals; Blood Gas Analysis; Disease Models, Animal; Lactic Acid; Male; Oxygen; Rats; Rats, Sprague- | 1998 |
Prognostic value of blood lactate, base deficit, and oxygen-derived variables in an LD50 model of penetrating trauma.
Topics: Analysis of Variance; Animals; Critical Care; Hemodynamics; Lactic Acid; Lethal Dose 50; Morbidity; | 1999 |
Controlled resuscitation for uncontrolled hemorrhagic shock.
Topics: Animals; Aorta; Disease Models, Animal; Fluid Therapy; Hematocrit; Hydroxyethyl Starch Derivatives; | 1999 |
Adrenergic antagonists reduce lactic acidosis in response to hemorrhagic shock.
Topics: Acidosis, Lactic; Adrenergic alpha-Antagonists; Adrenergic Antagonists; Adrenergic beta-Antagonists; | 1999 |
Diaspirin cross-linked hemoglobin effectively restores pancreatic microcirculatory failure in hemorrhagic shock.
Topics: Acid-Base Equilibrium; Animals; Aspirin; Blood Substitutes; Cell Adhesion; Cross-Linking Reagents; E | 1999 |
Effects of traditional versus delayed resuscitation on serum lactate and base deficit.
Topics: Animals; Blood Pressure; Female; Lactic Acid; Resuscitation; Shock, Hemorrhagic; Swine; Time Factors | 1999 |
The effects of interleukin-10 in hemorrhagic shock.
Topics: Animals; Interleukin-1; Interleukin-10; Interleukin-6; Lactic Acid; Male; Rats; Rats, Sprague-Dawley | 2000 |
Depletion of lactate by dichloroacetate reduces cardiac efficiency after hemorrhagic shock.
Topics: Acidosis, Lactic; Animals; Dichloroacetic Acid; Dogs; Drug Evaluation, Preclinical; Energy Metabolis | 2000 |
Lactate improves cardiac efficiency after hemorrhagic shock.
Topics: Acetyl Coenzyme A; Acyl Coenzyme A; Animals; Cardiac Output; Citric Acid Cycle; Energy Metabolism; E | 2000 |
[Arterial plasma nitric oxide and lactate level in hemorrhagic shock patients].
Topics: Adolescent; Adult; Female; Humans; Lactic Acid; Male; Nitric Oxide; Prognosis; Shock, Hemorrhagic | 1998 |
Monitoring tissue oxygenation during resuscitation of major burns.
Topics: Adult; Aged; Blood Gas Monitoring, Transcutaneous; Blood Pressure; Body Surface Area; Burns; Carbon | 2001 |
Effects of ethanol and naltrexone in a model of traumatic brain injury with hemorrhagic shock.
Topics: Animals; Blood Pressure; Brain; Brain Injuries; Cardiac Output; Ethanol; Hydrogen-Ion Concentration; | 2001 |
Re.: Nitroprusside in resuscitation of major torso trauma.
Topics: Humans; Hydrogen-Ion Concentration; Lactic Acid; Nitroprusside; Oxygen; Shock, Hemorrhagic; Thoracic | 2001 |
Adrenergic blockade reduces skeletal muscle glycolysis and Na(+), K(+)-ATPase activity during hemorrhage.
Topics: Adenosine Triphosphate; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Blood Ga | 2001 |
Mesenteric and renal oxygen transport during hemorrhage and reperfusion: evaluation of optimal goals for resuscitation.
Topics: Acid-Base Equilibrium; Animals; Female; Fluid Therapy; Gastric Acidity Determination; Hemodynamics; | 2001 |
A pig hemorrhagic shock model: oxygen debt and metabolic acidemia as indicators of severity.
Topics: Animals; Disease Models, Animal; Female; Lactic Acid; Oxygen; Predictive Value of Tests; Probability | 2001 |
Sodium pyruvate is better than sodium chloride as a resuscitation solution in a rodent model of profound hemorrhagic shock.
Topics: Animals; Blood Glucose; Cardiotonic Agents; Disease Models, Animal; Lactic Acid; Male; Pyruvic Acid; | 2001 |
Effects of hemorrhage on gastrointestinal oxygenation.
Topics: Analysis of Variance; Animals; Carbon Dioxide; Dogs; Gastric Mucosa; Hemodynamics; Hydrogen-Ion Conc | 2001 |
Preventive effect of glutamine on intestinal barrier dysfunction induced by severe trauma.
Topics: Amine Oxidase (Copper-Containing); Animals; Endotoxemia; Endotoxins; Glutamine; Intestinal Absorptio | 2002 |
Hypoxia is not the sole cause of lactate production during shock.
Topics: Analysis of Variance; Animals; Epinephrine; Ethanol; Hypoxia; Lactic Acid; Male; Microdialysis; Ouab | 2002 |
Impact of alcohol intoxication on hemodynamic, metabolic, and cytokine responses to hemorrhagic shock.
Topics: Alanine Transaminase; Alcoholic Intoxication; Animals; Bicarbonates; Blood Glucose; Carbon Dioxide; | 2002 |
[The correction of functional disorders of the hemostatic system and of the rheological properties of the blood in dogs in the late period of hemorrhagic shock by the intravenous transfusion of lactoprotein].
Topics: Albumins; Animals; Blood Coagulation Disorders; Blood Viscosity; Dogs; Drug Combinations; Drug Evalu | 1992 |
Beneficial effects of methionine on myocardial hemodynamic and cellular functions in hemorrhagic shock.
Topics: Animals; Blood Gas Analysis; Creatine Kinase; Dogs; Drug Evaluation, Preclinical; Female; Heart; Hem | 1992 |
Altered cellular calcium regulation and hepatic glucose production during hemorrhagic shock.
Topics: Animals; Blood Glucose; Calcium; Epinephrine; Fluorescent Dyes; Fura-2; Glucose; Kinetics; Lactates; | 1992 |
Beneficial effects of diltiazem in hemorrhagic shock.
Topics: Animals; Blood Glucose; Blood Pressure; Calcium Channels; Diltiazem; Heart Rate; Lactates; Lactic Ac | 1991 |
[Evaluation of the effectiveness of infusion solutions based on electron-microscopic studies].
Topics: Animals; Dextrans; Disease Models, Animal; Drug Evaluation, Preclinical; Lactates; Lactic Acid; Live | 1990 |
Relationship of plasma amino acids to oxygen debt during hemorrhagic shock.
Topics: Alanine; Amino Acids; Amino Acids, Branched-Chain; Animals; Blood Pressure; Cardiac Output; Dogs; Gl | 1991 |
Effects of pentoxifylline on hemodynamics, oxygen transport, and tissue metabolism in experimental, severe hemorrhagic shock.
Topics: Animals; Disease Models, Animal; Dogs; Double-Blind Method; Drug Evaluation, Preclinical; Hemodynami | 1991 |
Effects of sodium o-iodobenzoate on acid-base parameters and survival in dogs with hemorrhagic shock.
Topics: 2,3-Diphosphoglycerate; Acidosis; Animals; Bicarbonates; Diphosphoglyceric Acids; Dogs; Erythrocytes | 1991 |
Shock, transfusion, and pneumonectomy. Death is due to right heart failure and increased pulmonary vascular resistance.
Topics: Animals; Blood Pressure; Blood Transfusion; Cardiac Output; Cardiac Output, Low; Heart; Lactates; La | 1990 |
Alterations in metabolite levels in carbohydrate and energy metabolism of rat in hemorrhagic shock and sepsis.
Topics: Adenine Nucleotides; Animals; DNA; Energy Metabolism; Glucose-6-Phosphate; Glucosephosphates; Lactat | 1987 |
Changes in brain thyrotropin-releasing hormone in reversible and irreversible hemorrhagic shock in the rat.
Topics: Animals; Brain; Carbon Dioxide; Lactates; Lactic Acid; Male; Rats; Rats, Inbred Strains; Shock, Hemo | 1988 |
Influence of hemorrhagic shock on hepatic energy metabolism in carbon tetrachloride-induced cirrhotic rats.
Topics: Adenine Nucleotides; Animals; Carbon Tetrachloride; Energy Metabolism; Kinetics; Lactates; Lactic Ac | 1988 |
Effect of acute hypovolemic hypotension on cerebral metabolism in newborn piglets.
Topics: Animals; Animals, Newborn; Blood Glucose; Blood Pressure; Brain; Cerebrovascular Circulation; Energy | 1988 |
Renal, cerebral, and pulmonary effects of hypertonic resuscitation in a porcine model of hemorrhagic shock.
Topics: Animals; Blood Pressure; Brain; Cardiac Output; Creatinine; Disease Models, Animal; Female; Hemodyna | 1988 |
Extracellular-intracellular lactate gradients in skeletal muscle during hemorrhagic shock in the rat.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Extracellular Space; Glycolysis; Hematocrit; Lactate | 1985 |
Phase-related changes in tissue energy reserves during hemorrhagic shock.
Topics: Animals; Blood Glucose; Energy Metabolism; Glycogen; Hematocrit; Lactates; Lactic Acid; Liver; Liver | 1985 |