Page last updated: 2024-10-17

lactic acid and Heart Defects, Congenital

lactic acid has been researched along with Heart Defects, Congenital in 87 studies

Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.

Heart Defects, Congenital: Developmental abnormalities involving structures of the heart. These defects are present at birth but may be discovered later in life.

Research Excerpts

ExcerptRelevanceReference
" These factors (immaturity, hyperoxia, hypoxia, blood transfusions, intraventricular hemorrhage, apnea, infection, hypercarbia, hypocarbia, patent ductus arteriosus, prostaglandin synthetase inhibitors, vitamin E deficiency, lactic acidosis, prenatal complications, genetic factors) may all be present in an infant."4.76A reexamination of the role of oxygen in retrolental fibroplasia. ( Dangman, B; Lucey, JF, 1984)
"Preoperative MRI examinations showed periventricular leukomalacia (PVL) in 4 patients (16%) and infarct in 2 subjects (8%)."2.70An MRI study of neurological injury before and after congenital heart surgery. ( Chiavacci, RM; Clancy, RR; Galli, KK; Gaynor, JW; Kurth, CD; Mahle, WT; Montenegro, LM; Nicolson, SC; Spray, TL; Tavani, F; Wernovsky, G; Zimmerman, RA, 2002)
"Mean choline levels were higher in CHD compared with controls (CHD 2."1.91Magnetic Resonance Spectroscopy of Brain Metabolism in Fetuses With Congenital Heart Disease. ( Andescavage, NN; Cheng, JJ; Donofrio, MT; du Plessis, AJ; Gimovsky, AC; Kapse, K; Limperopoulos, C; Pradhan, S; Sharker, Y; Wessel, D, 2023)
"Major adverse events (MAE) are unexpected but undesirably frequent after pediatric congenital heart surgery and contribute to poorer outcomes."1.62Central Venous Oxygen Saturation/Lactate Ratio and Prediction of Major Adverse Events After Pediatric Heart Surgery. ( Carmona, F; Manso, PH; Rocha, VHS, 2021)
" The mean lactate half-life was 12."1.51Lactate clearance in infants undergoing surgery for congenital heart disease. ( Albinni, S; Berkia, I; Bojan, M; Desplanque, L; Hamaide-Defrocourt, F; Tourneur, T, 2019)
"In those with bacterial infection, procalcitonin was elevated on postoperative days 1-3 and the last measurement prior to event compared with those without bacterial infection."1.51Procalcitonin and Other Common Biomarkers Do Not Reliably Identify Patients at Risk for Bacterial Infection After Congenital Heart Surgery. ( Baines, P; Carrol, E; Chesters, C; D'Souza, S; Downey, C; Guhadasan, R; Jennings, R; Lane, S; Paulus, S; Siner, S; Thorburn, K, 2019)
"Survival of children having cardiac arrest refractory to conventional cardiopulmonary resuscitation (CPR) is very poor."1.40Results of rapid-response extracorporeal cardiopulmonary resuscitation in children with refractory cardiac arrest following cardiac surgery. ( Al-Ahmadi, M; Al-Halees, Z; Alsoufi, B; Awan, A; Guechef, A; Kalloghlian, A; Manlhiot, C; McCrindle, BW, 2014)
"Low cardiac output syndrome is common after paediatric cardiac surgery."1.38Serum cortisol concentration with exploratory cut-off values do not predict the effects of hydrocortisone administration in children with low cardiac output after cardiac surgery. ( de Jonge, E; Hazekamp, MG; Hogenbirk, K; Roest, AA; van Brempt, R; Verweij, EJ, 2012)
"Levosimendan produced an increase in cΔHbD (p < 0."1.37Acute effects of levosimendan on cerebral and systemic perfusion and oxygenation in newborns: an observational study. ( Bravo, MC; Bravo, Mdel C; Cabañas, F; López, P; Pellicer, A; Pérez-Fernández, E; Pérez-Rodríguez, J; Quero, J, 2011)
"Levosimendan is a calcium-sensitizing agent with effective inotropic properties."1.35First experiences with intraoperative Levosimendan in pediatric cardiac surgery. ( Boethig, D; Goerler, H; Huber, D; Osthaus, WA; Sasse, M; Sümpelmann, R; Winterhalter, M, 2009)
"Congenital heart disease is the leading cause of death in the first year after birth."1.31Prenatal diagnosis of congenital heart disease affects preoperative acidosis in the newborn patient. ( Bennink, GB; Brenner, JI; Copel, JA; Hitchcock, JF; Kleinman, CS; Lisowski, LA; Meijboom, EJ; Stoutenbeek, P; Verheijen, PM, 2001)

Research

Studies (87)

TimeframeStudies, this research(%)All Research%
pre-19908 (9.20)18.7374
1990's7 (8.05)18.2507
2000's28 (32.18)29.6817
2010's39 (44.83)24.3611
2020's5 (5.75)2.80

Authors

AuthorsStudies
Rocha, VHS1
Manso, PH2
Carmona, F2
Xia, Y1
Liu, M1
Fan, J1
Qiu, Y1
Zhang, X1
Zheng, Z1
Shi, S1
Andescavage, NN1
Pradhan, S1
Gimovsky, AC1
Kapse, K1
Donofrio, MT2
Cheng, JJ1
Sharker, Y1
Wessel, D1
du Plessis, AJ2
Limperopoulos, C2
Farias, JS1
Villarreal, EG1
Flores, S1
Mastropietro, CW1
Vogel, M1
Schulz, K1
Culichia, C1
Iliopoulos, ID1
Bronicki, RA1
Loomba, RS1
Jonas, MC1
Caneo, LF1
Turquetto, ALR1
Jatene, MB1
Lu, Z1
Wang, X1
Yang, J2
Li, S1
Yan, J1
Sughimoto, K1
Kohira, S1
Hayashi, H1
Torii, S1
Kitamura, T1
Horai, T1
Miyaji, K1
Desplanque, L1
Hamaide-Defrocourt, F1
Berkia, I1
Tourneur, T1
Albinni, S1
Bojan, M2
D'Souza, S1
Guhadasan, R1
Jennings, R1
Siner, S1
Paulus, S1
Thorburn, K1
Chesters, C1
Downey, C1
Baines, P1
Lane, S1
Carrol, E1
Yang, L1
Ye, L1
Fan, Y1
He, W1
Zong, Q1
Zhao, W1
Lin, R1
Bonaveglio, E1
Dolcino, A1
Mirabile, C1
Veeram Reddy, SR2
Welch, TR3
Wang, J3
Bernstein, F1
Richardson, JA2
Forbess, JM2
Nugent, AW2
Alsoufi, B1
Awan, A1
Manlhiot, C1
Guechef, A1
Al-Halees, Z1
Al-Ahmadi, M1
McCrindle, BW1
Kalloghlian, A1
Friedland-Little, JM1
Hirsch-Romano, JC1
Yu, S2
Donohue, JE1
Canada, CE1
Soraya, P1
Aiyagari, R1
Schumacher, KR1
Reichel, RA1
Vlasic, JR1
Donohue, J1
Gajarski, RJ1
Charpie, JR2
Tume, LN1
Arnold, P1
Miao, N1
Du, Z1
Liu, W1
Ni, H1
Xing, J1
Yang, X1
Xu, B1
Hou, X1
Alton, GY2
Taghados, S1
Joffe, AR3
Robertson, CM3
Dinu, I1
Riegel, M1
Goodfriend, AC1
Barker, G1
Ginther, R1
Riegel, MS1
Reddy, SV1
Nugent, A1
Forbess, J1
McCrossan, BA1
McMahon, CJ1
Walsh, KP1
Aly, SA1
Zurakowski, D2
Glass, P1
Skurow-Todd, K1
Jonas, RA1
Harbison, AL1
Votava-Smith, JK1
Del Castillo, S1
Kumar, SR1
Lee, V1
Schmithorst, V1
Lai, HA1
O'Neil, S1
Bluml, S1
Paquette, L1
Panigrahy, A1
Osthaus, WA1
Boethig, D1
Winterhalter, M1
Huber, D1
Goerler, H1
Sasse, M1
Sümpelmann, R1
Li, P1
Yuan, D1
Luo, WJ1
Tworetzky, W1
McElhinney, DB1
Newburger, JW3
Brown, DW1
Robertson, RL1
Guizard, N1
McGrath, E2
Geva, J1
Annese, D1
Dunbar-Masterson, C1
Trainor, B1
Laussen, PC4
Rossi, AF4
Lopez, L1
Dobrolet, N1
Khan, D2
Bolivar, J2
Molina Hazan, V1
Gonen, Y1
Vardi, A1
Keidan, I1
Mishali, D1
Rubinshtein, M1
Yakov, Y1
Paret, G2
Verheijen, PM3
Lisowski, LA3
Wassink, S1
Visser, GH1
Meijboom, EJ4
Allan, CK1
Elder, J1
Psoinos, C1
del Nido, PJ1
Wypij, D1
McGowan, FX2
Bravo, MC1
Bravo, Mdel C1
López, P1
Cabañas, F1
Pérez-Rodríguez, J1
Pérez-Fernández, E1
Quero, J1
Pellicer, A1
Golab, HD2
Scohy, TV1
de Jong, PL1
Kissler, J1
Takkenberg, JJ2
Bogers, AJ2
Polimenakos, AC1
Wojtyla, P1
Smith, PJ1
Rizzo, V1
Nater, M1
El Zein, CF1
Ilbawi, MN1
Boks, RH1
Algra, SO2
Kornmann, VN1
van der Tweel, I2
Schouten, AN2
Jansen, NJ2
Haas, F2
Dumaresq, DM1
Vasconcelos, RC1
Guimarães, SB1
Cavalcante, SL1
Garcia, JH1
Vasconcelos, AR1
Maarslet, L1
Møller, MB1
Dall, R1
Hjortholm, K1
Ravn, H1
Gupta, P1
Jines, P1
Gossett, JM1
Maurille, M1
Hanley, FL1
Reddy, VM1
Miyake, CY1
Roth, SJ2
van Oeveren, W1
Schoof, PH1
Mehta, NM1
Costello, JM1
Bechard, LJ1
Johnson, VM1
Duggan, CP1
Molina-Hazan, V1
Verweij, EJ1
Hogenbirk, K1
Roest, AA1
van Brempt, R1
Hazekamp, MG1
de Jonge, E1
Amirnovin, R1
Keller, RL1
Herrera, C1
Hsu, JH1
Datar, S1
Karl, TR1
Adatia, I1
Oishi, P1
Fineman, JR1
Mackie, AS1
Dinu, IA1
Nishibe, S1
Tsujita, M1
Park, SJ1
Kim, HS1
Byon, HJ1
Kim, CS1
Cheong, IY1
Kim, JT1
Mahle, WT1
Tavani, F1
Zimmerman, RA1
Nicolson, SC1
Galli, KK1
Gaynor, JW1
Clancy, RR1
Montenegro, LM1
Spray, TL2
Chiavacci, RM1
Wernovsky, G2
Kurth, CD1
Hoffman, TM1
Atz, AM1
Kulik, TJ2
Nelson, DP1
Chang, AC1
Bailey, JM1
Akbary, A1
Kocsis, JF1
Kaczmarek, R1
Wessel, DL2
HOLMGREN, A1
STROM, G1
CASTELLO, D1
MADON, E1
GREENE, NM1
TALNER, NS1
LEVISON, H1
SWYER, PR1
JOVINO, R1
MASTRANDREA, F1
MUSELLA, S1
HAVEL, RJ1
WATKINS, E1
Ishida, R1
Oiwa, H1
Honda, K1
Imamura, K1
Nonaka, T1
Sudo, K1
Ootaki, Y1
Yamaguchi, M2
Yoshimura, N2
Oka, S1
Yoshida, M2
Hasegawa, T1
Modi, P1
Suleiman, MS1
Reeves, B1
Pawade, A1
Parry, AJ1
Angelini, GD1
Caputo, M1
Gessler, P2
Pretre, R1
Hohl, V1
Rousson, V2
Fischer, J1
Dahinden, C1
Khan, DM1
Hannan, R1
Zaidenweber, M1
Burke, R1
Durward, A1
Tibby, SM2
Skellett, S1
Austin, C1
Anderson, D2
Murdoch, IA2
Ohuchi, H1
Hayashi, T1
Yamada, O1
Echigo, S1
Cheung, PY1
Chui, N1
Rebeyka, IM1
Hannan, RL2
Ybarra, MA1
White, JA1
Ojito, JW1
Burke, RP1
Hamamoto, M2
Imanaka, H2
Kagisaki, K1
Yagihara, T2
Kitamura, S1
Nishimura, M1
Baslaim, G1
Bashore, J1
Al-Malki, F1
Jamjoom, A1
Knirsch, W1
Schmitt, B1
von Eckardstein, A1
Uemura, H1
Oshima, Y1
Murakami, H1
Matsuhisa, H1
Amark, K1
Ekroth, R1
Nilsson, K1
Sunnegårdh, J1
Söderberg, B1
Lam, CT1
Sharma, S1
Baker, RS1
Hilshorst, J1
Lombardi, J1
Clark, KE1
Eghtesady, P1
Fenton, KN1
Schelbert, HR1
Benson, L1
Schwaiger, M1
Perloff, J1
Lucey, JF1
Dangman, B1
Toffaletti, J1
Hansell, D1
Hasan, RA1
Sarnaik, AP1
Meert, KL1
Dabbagh, S1
Simpson, P1
Makimi, M1
Harinck, E1
Hutter, PA1
Hoorntje, TM1
Simons, M1
Benatar, AA1
Fischer, JC1
de Bruijn, D1
Schranz, D1
Schnittker, C1
Michel-Behnke, I1
Schmid, FX1
Wippermann, CF1
Siegel, LB1
Dalton, HJ1
Hertzog, JH1
Hopkins, RA1
Hauser, GJ1
Hatherill, M1
Sajjanhar, T1
Champion, MP1
Marsh, MJ1
Munoz, R1
Palacio, G1
Zienko, L1
Piercey, G1
Dekeon, MK1
Goldberg, CS1
Mosca, RS1
Bove, EL1
Stoutenbeek, P2
Hitchcock, JF2
Brenner, JI1
Copel, JA1
Kleinman, CS1
Bennink, GB2
Shime, N1
Kageyama, K1
Ashida, H1
Ueda, M1
Kitamura, Y1
Tanaka, Y1
Corno, AF1
Milano, G1
Samaja, M1
Tozzi, P1
von Segesser, LK1
Smolenski, RT1
Swierczyński, J1
Narkiewicz, M1
Zydowo, MM1

Clinical Trials (17)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Newborn Project: A Prospective Observational Study Examining the Oxygenation of Brain Tissue During General Anesthesia Using Near Infrared Spectroscopy Technology[NCT03057587]0 participants (Actual)Observational2017-05-12Withdrawn (stopped due to The research never began.)
Perioperative Levosimendan Administration in Neonates With Transposition of the Great Arteries: Randomized Controlled Trial[NCT01120106]Phase 263 participants (Actual)Interventional2009-01-31Completed
Fetal Cerebrovascular Autoregulation in Congenital Heart Disease and Association With Neonatal Neurobehavior[NCT05767385]Phase 2/Phase 3150 participants (Anticipated)Interventional2021-12-17Recruiting
Removal of Cytokines in Patients Undergoing Cardiac Surgery With CPB (The REMOTE Study)[NCT03104179]80 participants (Anticipated)Interventional2017-05-31Not yet recruiting
Phase I Study of Two Inodilators in Neonates Undergoing Cardiovascular Surgery[NCT01576094]Phase 1/Phase 220 participants (Actual)Interventional2009-11-30Completed
Albumin vs. Plasma for PEdiAtric pRiming Trial[NCT02738190]Phase 480 participants (Actual)Interventional2015-01-31Completed
Randomized Controlled Trial on Deep Hypothermic Circulatory Arrest Versus Antegrade Cerebral Perfusion During Neonatal Cardiac Surgery[NCT01032876]37 participants (Actual)Interventional2009-01-31Completed
Cerebral Anatomy, Hemodynamics and Metabolism In Single Ventricles: Relationship to Neurodevelopment[NCT02919956]119 participants (Actual)Observational2016-04-30Active, not recruiting
International Study of Cerebral Oxygenation and Electrical Activity During Major Neonatal Surgery[NCT05673499]900 participants (Anticipated)Observational2022-08-12Recruiting
Autologous Cord Blood Cells for Patients With HLHS: Phase I Study of Feasibility and Safety[NCT01445041]Phase 17 participants (Actual)Interventional2011-09-01Terminated (stopped due to Funding Period Ended)
STeroids to REduce Systemic Inflammation After Infant Heart Surgery (STRESS)[NCT03229538]Phase 31,263 participants (Actual)Interventional2017-10-18Completed
Phase 2 Prospective, Randomized, Double-Blind Pilot Study on Cardiac Output Following Corrective Open Heart Surgery in Children Less Than One Year: Use of Levosimendan Versus Milrinone.[NCT00549107]Phase 240 participants (Anticipated)Interventional2007-09-30Recruiting
Preoperative Corticosteroid Therapy in Neonates Undergoing Cardiopulmonary Bypass[NCT00934843]77 participants (Actual)Interventional2007-03-31Completed
Use of the Cardioprotectant Dexrazoxane During Congenital Heart Surgery: Proposal for Pilot Investigation[NCT02519335]Phase 112 participants (Actual)Interventional2014-09-30Terminated (stopped due to PI no longer at this facility)
2- Inhaled Milrinone Prevents the Increase in Pulmonary Artery Pressure After CPB[NCT00819377]Phase 2124 participants (Anticipated)Interventional2009-02-28Completed
Use of the Cardioprotectant Dexrazoxane During Congenital Heart Surgery[NCT04997291]Phase 112 participants (Anticipated)Interventional2021-04-09Recruiting
Early Lactate-Directed Therapy on the ICU: A Randomized Controlled Trial[NCT00270673]Phase 3350 participants (Anticipated)Interventional2006-02-28Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Number of Participants With a Post-operative Length of Stay Greater Than 90 Days

Calculated as discharge date minus surgery date. (NCT03229538)
Timeframe: Until hospital discharge, up to 4 months

InterventionParticipants (Count of Participants)
Methylprednisolone Arm18
Placebo Arm29

Number of Participants With Any Other Post-operative Complications From the Start of Study Drug Administration Until Hospital Discharge.

(NCT03229538)
Timeframe: Until hospital discharge, up to 4 months

InterventionParticipants (Count of Participants)
Methylprednisolone Arm237
Placebo Arm264

Number of Participants With Death or Major Complication as Defined by an Outcome in One of the 7 Highest Global Ranking Categories

The 7 highest global ranking categories range from 91 (postoperative length of hospital stay > 90 days) to 97 (operative mortality). (NCT03229538)
Timeframe: Until hospital discharge, up to 4 months

InterventionParticipants (Count of Participants)
Methylprednisolone Arm103
Placebo Arm122

Number of Participants With Mortality, Including In-hospital Mortality or Mortality After Hospital Discharge But Within 30 Days of the Last Dose of Study Drug

(NCT03229538)
Timeframe: up to 30 days

InterventionParticipants (Count of Participants)
Methylprednisolone Arm12
Placebo Arm17

Number of Participants With Occurrence of Any One or More of the Following STS-CHSD-defined Major Post-operative Infectious Complications: Postprocedural Infective Endocarditis, Pneumonia, Sepsis, Deep Wound Infection, Mediastinitis.

(NCT03229538)
Timeframe: Until hospital discharge, up to 4 months

InterventionParticipants (Count of Participants)
Methylprednisolone Arm31
Placebo Arm24

Number of Participants With Post-operative Low Cardiac Output Syndrome

"Based upon the STS-CHSD registry defined cardiac dysfunction resulting in low cardiac output complication variable." (NCT03229538)
Timeframe: Until hospital discharge, up to 4 months

InterventionParticipants (Count of Participants)
Methylprednisolone Arm31
Placebo Arm37

Number of Participants With Prolonged Mechanical Ventilation (Greater Than 7 Days)

(NCT03229538)
Timeframe: Until hospital discharge, up to 4 months

InterventionParticipants (Count of Participants)
Methylprednisolone Arm41
Placebo Arm51

Inotropic Score

The inotropic score was calculated by the equation using drug dosages in micrograms/kg/min, (dopamine+dobutamine) + (milrinonex10) + (epinephrinex100) and recorded hourly upon arrival to the ICUthrough 36 hours postoperatively. The highest score during this timeframe was recorded. This score converts dosages of commonly used inotropic medications into a score. The higher the score the more inotropic medications required. The minimum score would be zero indicating no inotropic medications were used. There is no maximum score. (NCT00934843)
Timeframe: over the first 36 hours after surgery

InterventionScores on a scale (Mean)
MP Single Dose14.4
MP Two Dose15.0

Number of Participants Who Died Between 36 Hours and 30 Days Following Cardiac Surgery

Number of participants who died of any cause between 36 hours and 30 days following cardiac surgery (NCT00934843)
Timeframe: at 36 hours and 30 days

Interventionparticipants (Number)
MP Single Dose1
MP Two Dose0

Primary Endpoint: Number of Participants With Low Cardiac Output Syndrome (LCOS) or Death at 36 Hours From Admission to the Intensive Care Unit (ICU) After Surgery.

The presence of low cardiac output syndrome (LCOS) was defined by the same definition used in the PRIMACORP study (Hoffman TM.et.al. Circulation 2003 107:996-1002). Specifically, if there were clinical signs and symptoms of low cardiac output (e.g., tachycardia, oliguria, cold extremities, cardiac arrest, etc.) which required one or more of the following interventions: mechanical circulatory support, the escalation of existing pharmacological circulatory support to >100% over baseline, or the initiation of new pharmacological circulatory support. (NCT00934843)
Timeframe: 36 hours

Interventionparticipants (Number)
MP Single Dose17
MP Two Dose15

Urine Output

Total urine output in mL over the first 36 hours after cardiac surgery (NCT00934843)
Timeframe: over 36 hours

InterventionmL (Mean)
MP Single Dose498
MP Two Dose453

Total Intake/Output of Fluid

Total amount of all fluids in and out during the first 36 hours postoperatively in mL. (NCT00934843)
Timeframe: over 36 hours

,
InterventionmL (Mean)
Total Fluid in at 36 hrTotal Fluid out at 36 hr
MP Single Dose575600
MP Two Dose586558

Reviews

2 reviews available for lactic acid and Heart Defects, Congenital

ArticleYear
Effects of Vasopressin Infusion After Pediatric Cardiac Surgery: A Meta-analysis.
    Pediatric cardiology, 2021, Volume: 42, Issue:2

    Topics: Blood Pressure; Cardiac Surgical Procedures; Child, Preschool; Female; Heart Defects, Congenital; He

2021
A reexamination of the role of oxygen in retrolental fibroplasia.
    Pediatrics, 1984, Volume: 73, Issue:1

    Topics: Anencephaly; Apnea; Carbon Dioxide; Cerebral Hemorrhage; Ductus Arteriosus, Patent; Exchange Transfu

1984

Trials

11 trials available for lactic acid and Heart Defects, Congenital

ArticleYear
Vasopressin in Vasodilatory Shock for Both Left and Right Heart Anomalous Pediatric Patients After Cardiac Surgery.
    Shock (Augusta, Ga.), 2018, Volume: 50, Issue:2

    Topics: Adolescent; Blood Pressure; Cardiopulmonary Bypass; Child; Child, Preschool; Female; Heart Defects,

2018
Comparison of low molecular weight hydroxyethyl starch and human albumin as priming solutions in children undergoing cardiac surgery.
    Perfusion, 2014, Volume: 29, Issue:5

    Topics: Blood Glucose; Cardiopulmonary Bypass; Creatinine; Female; Heart Defects, Congenital; Hematocrit; Hu

2014
Relevance of colloid oncotic pressure regulation during neonatal and infant cardiopulmonary bypass: a prospective randomized study.
    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2011, Volume: 39, Issue:6

    Topics: Body Weight; Cardiopulmonary Bypass; Colloids; Double-Blind Method; Drug Administration Schedule; Fe

2011
Metabolic and oxidative effects of sevoflurane and propofol in children undergoing surgery for congenital heart disease.
    Acta cirurgica brasileira, 2011, Volume: 26 Suppl 1

    Topics: Adolescent; Anesthetics, Inhalation; Anesthetics, Intravenous; Child; Child, Preschool; Female; Glut

2011
Low-flow antegrade cerebral perfusion attenuates early renal and intestinal injury during neonatal aortic arch reconstruction.
    The Journal of thoracic and cardiovascular surgery, 2012, Volume: 144, Issue:6

    Topics: Aorta, Thoracic; Biomarkers; Cerebrovascular Circulation; Circulatory Arrest, Deep Hypothermia Induc

2012
An MRI study of neurological injury before and after congenital heart surgery.
    Circulation, 2002, Sep-24, Volume: 106, Issue:12 Suppl 1

    Topics: Brain; Brain Chemistry; Cardiopulmonary Bypass; Cerebral Infarction; Cerebrovascular Disorders; Coho

2002
An MRI study of neurological injury before and after congenital heart surgery.
    Circulation, 2002, Sep-24, Volume: 106, Issue:12 Suppl 1

    Topics: Brain; Brain Chemistry; Cardiopulmonary Bypass; Cerebral Infarction; Cerebrovascular Disorders; Coho

2002
An MRI study of neurological injury before and after congenital heart surgery.
    Circulation, 2002, Sep-24, Volume: 106, Issue:12 Suppl 1

    Topics: Brain; Brain Chemistry; Cardiopulmonary Bypass; Cerebral Infarction; Cerebrovascular Disorders; Coho

2002
An MRI study of neurological injury before and after congenital heart surgery.
    Circulation, 2002, Sep-24, Volume: 106, Issue:12 Suppl 1

    Topics: Brain; Brain Chemistry; Cardiopulmonary Bypass; Cerebral Infarction; Cerebrovascular Disorders; Coho

2002
An MRI study of neurological injury before and after congenital heart surgery.
    Circulation, 2002, Sep-24, Volume: 106, Issue:12 Suppl 1

    Topics: Brain; Brain Chemistry; Cardiopulmonary Bypass; Cerebral Infarction; Cerebrovascular Disorders; Coho

2002
An MRI study of neurological injury before and after congenital heart surgery.
    Circulation, 2002, Sep-24, Volume: 106, Issue:12 Suppl 1

    Topics: Brain; Brain Chemistry; Cardiopulmonary Bypass; Cerebral Infarction; Cerebrovascular Disorders; Coho

2002
An MRI study of neurological injury before and after congenital heart surgery.
    Circulation, 2002, Sep-24, Volume: 106, Issue:12 Suppl 1

    Topics: Brain; Brain Chemistry; Cardiopulmonary Bypass; Cerebral Infarction; Cerebrovascular Disorders; Coho

2002
An MRI study of neurological injury before and after congenital heart surgery.
    Circulation, 2002, Sep-24, Volume: 106, Issue:12 Suppl 1

    Topics: Brain; Brain Chemistry; Cardiopulmonary Bypass; Cerebral Infarction; Cerebrovascular Disorders; Coho

2002
An MRI study of neurological injury before and after congenital heart surgery.
    Circulation, 2002, Sep-24, Volume: 106, Issue:12 Suppl 1

    Topics: Brain; Brain Chemistry; Cardiopulmonary Bypass; Cerebral Infarction; Cerebrovascular Disorders; Coho

2002
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
    Circulation, 2003, Feb-25, Volume: 107, Issue:7

    Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin

2003
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
    Circulation, 2003, Feb-25, Volume: 107, Issue:7

    Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin

2003
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
    Circulation, 2003, Feb-25, Volume: 107, Issue:7

    Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin

2003
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
    Circulation, 2003, Feb-25, Volume: 107, Issue:7

    Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin

2003
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
    Circulation, 2003, Feb-25, Volume: 107, Issue:7

    Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin

2003
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
    Circulation, 2003, Feb-25, Volume: 107, Issue:7

    Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin

2003
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
    Circulation, 2003, Feb-25, Volume: 107, Issue:7

    Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin

2003
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
    Circulation, 2003, Feb-25, Volume: 107, Issue:7

    Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin

2003
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
    Circulation, 2003, Feb-25, Volume: 107, Issue:7

    Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin

2003
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
    Circulation, 2003, Feb-25, Volume: 107, Issue:7

    Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin

2003
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
    Circulation, 2003, Feb-25, Volume: 107, Issue:7

    Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin

2003
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
    Circulation, 2003, Feb-25, Volume: 107, Issue:7

    Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin

2003
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
    Circulation, 2003, Feb-25, Volume: 107, Issue:7

    Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin

2003
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
    Circulation, 2003, Feb-25, Volume: 107, Issue:7

    Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin

2003
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
    Circulation, 2003, Feb-25, Volume: 107, Issue:7

    Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin

2003
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
    Circulation, 2003, Feb-25, Volume: 107, Issue:7

    Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin

2003
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
    Circulation, 2003, Feb-25, Volume: 107, Issue:7

    Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin

2003
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
    Circulation, 2003, Feb-25, Volume: 107, Issue:7

    Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin

2003
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
    Circulation, 2003, Feb-25, Volume: 107, Issue:7

    Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin

2003
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
    Circulation, 2003, Feb-25, Volume: 107, Issue:7

    Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin

2003
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
    Circulation, 2003, Feb-25, Volume: 107, Issue:7

    Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin

2003
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
    Circulation, 2003, Feb-25, Volume: 107, Issue:7

    Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin

2003
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
    Circulation, 2003, Feb-25, Volume: 107, Issue:7

    Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin

2003
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
    Circulation, 2003, Feb-25, Volume: 107, Issue:7

    Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin

2003
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
    Circulation, 2003, Feb-25, Volume: 107, Issue:7

    Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin

2003
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
    Circulation, 2003, Feb-25, Volume: 107, Issue:7

    Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin

2003
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
    Circulation, 2003, Feb-25, Volume: 107, Issue:7

    Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin

2003
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
    Circulation, 2003, Feb-25, Volume: 107, Issue:7

    Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin

2003
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
    Circulation, 2003, Feb-25, Volume: 107, Issue:7

    Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin

2003
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
    Circulation, 2003, Feb-25, Volume: 107, Issue:7

    Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin

2003
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
    Circulation, 2003, Feb-25, Volume: 107, Issue:7

    Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin

2003
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
    Circulation, 2003, Feb-25, Volume: 107, Issue:7

    Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin

2003
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
    Circulation, 2003, Feb-25, Volume: 107, Issue:7

    Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin

2003
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
    Circulation, 2003, Feb-25, Volume: 107, Issue:7

    Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin

2003
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
    Circulation, 2003, Feb-25, Volume: 107, Issue:7

    Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin

2003
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
    Circulation, 2003, Feb-25, Volume: 107, Issue:7

    Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin

2003
Myocardial metabolic changes during pediatric cardiac surgery: a randomized study of 3 cardioplegic techniques.
    The Journal of thoracic and cardiovascular surgery, 2004, Volume: 128, Issue:1

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Biomarkers; Cardiac Surgical Procedures; Child; Child

2004
CXC-chemokine stimulation of neutrophils correlates with plasma levels of myeloperoxidase and lactoferrin and contributes to clinical outcome after pediatric cardiac surgery.
    Shock (Augusta, Ga.), 2004, Volume: 22, Issue:6

    Topics: Chemokine CCL2; Chemokines, CXC; Child; Child, Preschool; Down-Regulation; Heart Defects, Congenital

2004
Patterns of lactate values after congenital heart surgery and timing of cardiopulmonary support.
    The Annals of thoracic surgery, 2005, Volume: 80, Issue:4

    Topics: Cardiopulmonary Resuscitation; Heart Arrest; Heart Defects, Congenital; Humans; Lactic Acid; Postope

2005
Serial blood lactate measurements predict early outcome after neonatal repair or palliation for complex congenital heart disease.
    The Journal of thoracic and cardiovascular surgery, 2000, Volume: 120, Issue:1

    Topics: Extracorporeal Membrane Oxygenation; Heart Defects, Congenital; Humans; Infant, Newborn; Lactic Acid

2000

Other Studies

74 other studies available for lactic acid and Heart Defects, Congenital

ArticleYear
Central Venous Oxygen Saturation/Lactate Ratio and Prediction of Major Adverse Events After Pediatric Heart Surgery.
    Brazilian journal of cardiovascular surgery, 2021, 12-07, Volume: 36, Issue:6

    Topics: Cardiac Surgical Procedures; Child; Heart Defects, Congenital; Humans; Infant; Lactic Acid; Oxygen;

2021
Risk factors of postoperative neurodevelopmental abnormalities in neonates with critical congenital heart disease.
    Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2023, Feb-25, Volume: 52, Issue:1

    Topics: Child; Heart Defects, Congenital; Humans; Infant; Infant, Newborn; Lactic Acid; Prognosis; Retrospec

2023
Magnetic Resonance Spectroscopy of Brain Metabolism in Fetuses With Congenital Heart Disease.
    Journal of the American College of Cardiology, 2023, 10-17, Volume: 82, Issue:16

    Topics: Brain; Choline; Female; Fetus; Heart Defects, Congenital; Humans; Infant; Lactic Acid; Magnetic Reso

2023
Risk factors for death or mechanical ventilation time after bidirectional cavopulmonary anastomosis in a developing country.
    Cardiology in the young, 2022, Volume: 32, Issue:3

    Topics: Developing Countries; Fontan Procedure; Heart Defects, Congenital; Hospital Mortality; Humans; Infan

2022
Markers of peripheral perfusion during high-flow regional cerebral perfusion for aortic arch repair.
    The Journal of thoracic and cardiovascular surgery, 2018, Volume: 156, Issue:6

    Topics: Age Factors; Aorta, Thoracic; Biomarkers; Blood Flow Velocity; Cardiopulmonary Bypass; Cerebrovascul

2018
Lactate clearance in infants undergoing surgery for congenital heart disease.
    Artificial organs, 2019, Volume: 43, Issue:1

    Topics: Cardiac Surgical Procedures; Cardiopulmonary Bypass; Erythrocyte Transfusion; Half-Life; Heart Defec

2019
Procalcitonin and Other Common Biomarkers Do Not Reliably Identify Patients at Risk for Bacterial Infection After Congenital Heart Surgery.
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2019, Volume: 20, Issue:3

    Topics: Adolescent; Bacterial Infections; Biomarkers; Blood Platelets; C-Reactive Protein; Cardiac Surgical

2019
Outcomes following venoarterial extracorporeal membrane oxygenation in children with refractory cardiogenic disease.
    European journal of pediatrics, 2019, Volume: 178, Issue:6

    Topics: Child; Child, Preschool; Extracorporeal Membrane Oxygenation; Female; Heart Defects, Congenital; Hos

2019
Somatic and cerebral near infrared spectroscopy for the monitoring of perfusion during neonatal cardiopulmonary bypass.
    Interactive cardiovascular and thoracic surgery, 2019, 12-01, Volume: 29, Issue:6

    Topics: Biomarkers; Brain; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cerebrovascular Circulation;

2019
A novel biodegradable stent applicable for use in congenital heart disease: bench testing and feasibility results in a rabbit model.
    Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 2014, Feb-15, Volume: 83, Issue:3

    Topics: Absorbable Implants; Animals; Arterial Occlusive Diseases; Arteritis; Cardiac Catheterization; Cathe

2014
Results of rapid-response extracorporeal cardiopulmonary resuscitation in children with refractory cardiac arrest following cardiac surgery.
    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2014, Volume: 45, Issue:2

    Topics: Cardiac Surgical Procedures; Cardiopulmonary Resuscitation; Child; Child, Preschool; Extracorporeal

2014
Risk factors for requiring extracorporeal membrane oxygenation support after a Norwood operation.
    The Journal of thoracic and cardiovascular surgery, 2014, Volume: 148, Issue:1

    Topics: Area Under Curve; Biomarkers; Birth Weight; Cardiopulmonary Bypass; Chi-Square Distribution; Extraco

2014
Rate of increase in serum lactate level risk-stratifies infants after surgery for congenital heart disease.
    The Journal of thoracic and cardiovascular surgery, 2014, Volume: 148, Issue:2

    Topics: Acidosis, Lactic; Age Factors; Area Under Curve; Biomarkers; Cardiac Surgical Procedures; Cardiopulm

2014
Near-infrared spectroscopy after high-risk congenital heart surgery in the paediatric intensive care unit.
    Cardiology in the young, 2015, Volume: 25, Issue:3

    Topics: Cardiac Surgical Procedures; England; Female; Heart Defects, Congenital; Humans; Infant; Infant, New

2015
Prediction of preschool functional abilities after early complex cardiac surgery.
    Cardiology in the young, 2015, Volume: 25, Issue:4

    Topics: Activities of Daily Living; Canada; Cardiac Surgical Procedures; Child, Preschool; Female; Heart Def

2015
A novel design biodegradable stent for use in congenital heart disease: mid-term results in rabbit descending aorta.
    Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 2015, Volume: 85, Issue:4

    Topics: Absorbable Implants; Animals; Aorta, Thoracic; Aortic Diseases; Aortography; Arterial Occlusive Dise

2015
Novel bioresorbable stent coating for drug release in congenital heart disease applications.
    Journal of biomedical materials research. Part A, 2015, Volume: 103, Issue:5

    Topics: Absorbable Implants; Animals; Coated Materials, Biocompatible; Dexamethasone; Drug Liberation; Drug-

2015
First reported use of drug-eluting bioabsorbable vascular scaffold in congenital heart disease.
    Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 2016, Feb-01, Volume: 87, Issue:2

    Topics: Absorbable Implants; Angioplasty, Balloon; Cardiovascular Agents; Child; Coated Materials, Biocompat

2016
Cerebral tissue oxygenation index and lactate at 24 hours postoperative predict survival and neurodevelopmental outcome after neonatal cardiac surgery.
    Congenital heart disease, 2017, Volume: 12, Issue:2

    Topics: Age Factors; Area Under Curve; Biomarkers; Brain; Cardiac Surgical Procedures; Cerebrovascular Circu

2017
Clinical Factors Associated with Cerebral Metabolism in Term Neonates with Congenital Heart Disease.
    The Journal of pediatrics, 2017, Volume: 183

    Topics: Aspartic Acid; Biomarkers; Birth Weight; Brain; Cohort Studies; Female; Gestational Age; Glutamine;

2017
First experiences with intraoperative Levosimendan in pediatric cardiac surgery.
    European journal of pediatrics, 2009, Volume: 168, Issue:6

    Topics: Cardiac Output; Cardiac Output, Low; Cardiac Surgical Procedures; Cardiotonic Agents; Heart; Heart D

2009
[Dynamic monitoring of arterial blood lactic acid in the prognosis of heart operation].
    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2008, Volume: 33, Issue:12

    Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Female; Heart Defects, Congenital; Humans; Infant;

2008
Brain volume and metabolism in fetuses with congenital heart disease: evaluation with quantitative magnetic resonance imaging and spectroscopy.
    Circulation, 2010, Jan-05, Volume: 121, Issue:1

    Topics: Aspartic Acid; Brain; Choline; Female; Gestational Age; Heart Defects, Congenital; Humans; Imaging,

2010
Hyperlactatemia in neonates admitted to the cardiac intensive care unit with critical heart disease.
    Neonatology, 2010, Volume: 98, Issue:2

    Topics: Acidosis, Lactic; Acute Disease; Heart Defects, Congenital; Humans; Infant, Newborn; Intensive Care

2010
Blood lactate levels differ significantly between surviving and nonsurviving patients within the same risk-adjusted Classification for Congenital Heart Surgery (RACHS-1) group after pediatric cardiac surgery.
    Pediatric cardiology, 2010, Volume: 31, Issue:7

    Topics: Adolescent; Child; Child, Preschool; Female; Heart Defects, Congenital; Humans; Infant; Infant, Newb

2010
Preoperative acidosis and infant development following surgery for congenital heart disease.
    Herz, 2010, Volume: 35, Issue:5

    Topics: Acidosis, Lactic; Cardiopulmonary Bypass; Cohort Studies; Developmental Disabilities; Heart Arrest,

2010
The relationship between inflammatory activation and clinical outcome after infant cardiopulmonary bypass.
    Anesthesia and analgesia, 2010, Volume: 111, Issue:5

    Topics: Biomarkers; Boston; C-Reactive Protein; Cardiopulmonary Bypass; Heart Defects, Congenital; Hematocri

2010
Acute effects of levosimendan on cerebral and systemic perfusion and oxygenation in newborns: an observational study.
    Neonatology, 2011, Volume: 99, Issue:3

    Topics: Blood Pressure; Cardiac Output, Low; Cardiotonic Agents; Cerebrovascular Circulation; Heart Defects,

2011
Post-cardiotomy extracorporeal cardiopulmonary resuscitation in neonates with complex single ventricle: analysis of outcomes.
    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2011, Volume: 40, Issue:6

    Topics: Cardiopulmonary Resuscitation; Epidemiologic Methods; Extracorporeal Membrane Oxygenation; Female; H

2011
Washing of irradiated red blood cells in paediatric cardiopulmonary bypass: is it clinically useful? A retrospective audit.
    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2012, Volume: 41, Issue:2

    Topics: Blood Preservation; Blood Specimen Collection; Cardiopulmonary Bypass; Erythrocyte Transfusion; Eryt

2012
Increasing duration of circulatory arrest, but not antegrade cerebral perfusion, prolongs postoperative recovery after neonatal cardiac surgery.
    The Journal of thoracic and cardiovascular surgery, 2012, Volume: 143, Issue:2

    Topics: Aorta, Thoracic; Area Under Curve; Biomarkers; Cardiac Surgical Procedures; Cardiopulmonary Bypass;

2012
Lactate levels predict mortality and need for peritoneal dialysis in children undergoing congenital heart surgery.
    Acta anaesthesiologica Scandinavica, 2012, Volume: 56, Issue:4

    Topics: Acute Kidney Injury; Child, Preschool; Female; Heart Defects, Congenital; Humans; Infant; Intubation

2012
Predictors for use of temporary epicardial pacing wires after pediatric cardiac surgery.
    The Journal of thoracic and cardiovascular surgery, 2012, Volume: 144, Issue:3

    Topics: Academic Medical Centers; Arrhythmias, Cardiac; Biomarkers; California; Cardiac Catheterization; Car

2012
Resting energy expenditure after Fontan surgery in children with single-ventricle heart defects.
    JPEN. Journal of parenteral and enteral nutrition, 2012, Volume: 36, Issue:6

    Topics: Basal Metabolism; Calorimetry, Indirect; Child, Preschool; Energy Metabolism; Female; Fontan Procedu

2012
The combination of RACHS-1 and postoperative blood lactate levels is a better prognostic mean after pediatric cardiac surgery than each alone.
    Paediatric anaesthesia, 2012, Volume: 22, Issue:6

    Topics: Algorithms; Cardiac Surgical Procedures; Child; Heart Defects, Congenital; Humans; Lactic Acid; Logi

2012
Serum cortisol concentration with exploratory cut-off values do not predict the effects of hydrocortisone administration in children with low cardiac output after cardiac surgery.
    Interactive cardiovascular and thoracic surgery, 2012, Volume: 15, Issue:4

    Topics: Adrenal Insufficiency; Age Factors; Biomarkers; Blood Pressure; Cardiac Output, Low; Cardiac Surgica

2012
B-type natriuretic peptide levels predict outcomes in infants undergoing cardiac surgery in a lesion-dependent fashion.
    The Journal of thoracic and cardiovascular surgery, 2013, Volume: 145, Issue:5

    Topics: Biomarkers; Cardiac Surgical Procedures; Female; Heart Defects, Congenital; Heart Ventricles; Hemody

2013
Clinical outcome score predicts the need for neurodevelopmental intervention after infant heart surgery.
    The Journal of thoracic and cardiovascular surgery, 2013, Volume: 145, Issue:5

    Topics: Biomarkers; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cardiotonic Agents; Chi-Square Dist

2013
The impact of intraoperative vasopressin infusion in complex neonatal cardiac surgery.
    Interactive cardiovascular and thoracic surgery, 2012, Volume: 15, Issue:6

    Topics: Alanine Transaminase; Aspartate Aminotransferases; Biomarkers; Blood Urea Nitrogen; Cardiac Surgical

2012
Intraoperative plasma lactate as an early indicator of major postoperative events in pediatric cardiac patients.
    The Tohoku journal of experimental medicine, 2012, Volume: 228, Issue:3

    Topics: Biomarkers; Blood Gas Analysis; Cardiopulmonary Bypass; Heart Defects, Congenital; Humans; Intraoper

2012
Blood lactate concentration in relation to absolute and relative work load in normal men, and in mitral stenosis, atrial septal defect and vasoregulatory asthenia.
    Acta medica Scandinavica, 1959, Mar-04, Volume: 163, Issue:3

    Topics: Asthenia; Heart Defects, Congenital; Heart Septal Defects; Heart Septal Defects, Atrial; Heart Septu

1959
[BEHAVIOR OF BLOOD LACTIC ACID IN CHILDREN WITH HEART DISEASE. II. CONGENITAL HEART DISEASE].
    Minerva pediatrica, 1963, Dec-15, Volume: 15

    Topics: Aortic Coarctation; Blood Chemical Analysis; Child; Ductus Arteriosus; Ductus Arteriosus, Patent; He

1963
BLOOD LACTATE, PYRUVATE AND LACTATE-PYRUVATE RATIOS IN CONGENITAL HEART DISEASE.
    The New England journal of medicine, 1964, Jun-18, Volume: 270

    Topics: Blood Chemical Analysis; Child; Heart Defects, Congenital; Humans; Hypoxia; Lactates; Lactic Acid; N

1964
THE ACID-BASE STATUS IN CYANOTIC CONGENITAL HEART DISEASE.
    Canadian Medical Association journal, 1965, May-22, Volume: 92

    Topics: Acid-Base Equilibrium; Acidosis; Blood Gas Analysis; Cardiac Output; Heart Defects, Congenital; Huma

1965
[Blood lactic acid in cyanogenic congenital heart defects of surgical interest (pre- and postoperative study)].
    Rassegna internazionale di clinica e terapia, 1961, Dec-31, Volume: 41

    Topics: Heart Defects, Congenital; Humans; Lactates; Lactic Acid; Postoperative Period

1961
The metabolism of lactate and pyruvate in children with congenital heart disease.
    Circulation, 1950, Volume: 2, Issue:4

    Topics: Child; Heart; Heart Defects, Congenital; Humans; Lactates; Lactic Acid; Pyruvates; Pyruvic Acid

1950
[Evaluation of sternal deformity after pediatric minimally invasive cardiac surgery].
    Kyobu geka. The Japanese journal of thoracic surgery, 2004, Volume: 57, Issue:2

    Topics: Absorbable Implants; Adolescent; Bone Nails; Bone Wires; Cardiac Surgical Procedures; Child; Child,

2004
Efficacy of a criterion-driven transfusion protocol in patients having pediatric cardiac surgery.
    The Journal of thoracic and cardiovascular surgery, 2004, Volume: 127, Issue:4

    Topics: Adolescent; Biomarkers; Body Temperature; Body Weight; Cardiac Surgical Procedures; Cardiopulmonary

2004
Point of care testing: improving pediatric outcomes.
    Clinical biochemistry, 2004, Volume: 37, Issue:6

    Topics: Blood Gas Analysis; Carbon Dioxide; Florida; Heart Defects, Congenital; Hospital Mortality; Hospital

2004
Goal-directed medical therapy and point-of-care testing improve outcomes after congenital heart surgery.
    Intensive care medicine, 2005, Volume: 31, Issue:1

    Topics: Algorithms; Heart Defects, Congenital; Hospital Mortality; Hospitals, Pediatric; Humans; Infant; Inf

2005
The strong ion gap predicts mortality in children following cardiopulmonary bypass surgery.
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2005, Volume: 6, Issue:3

    Topics: Acid-Base Equilibrium; Acidosis, Lactic; Cardiopulmonary Bypass; Child, Preschool; Heart Defects, Co

2005
Change in plasma volume during peak exercise in patients with cyanotic congenital heart disease after definitive operation.
    International journal of cardiology, 2006, Apr-04, Volume: 108, Issue:2

    Topics: Adolescent; Child; Cyanosis; Electrocardiography; Exercise; Exercise Test; Fontan Procedure; Heart D

2006
Postoperative lactate concentrations predict the outcome of infants aged 6 weeks or less after intracardiac surgery: a cohort follow-up to 18 months.
    The Journal of thoracic and cardiovascular surgery, 2005, Volume: 130, Issue:3

    Topics: Biomarkers; Blindness; Cardiac Surgical Procedures; Cerebral Palsy; Child Development; Cohort Studie

2005
Is an increase in lactate concentration associated with cardiac dysfunction after the Fontan procedure?
    Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia, 2005, Volume: 11, Issue:5

    Topics: Adolescent; Cardiac Output; Child; Child, Preschool; Fontan Procedure; Heart Defects, Congenital; He

2005
Can the outcome of pediatric extracorporeal membrane oxygenation after cardiac surgery be predicted?
    Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia, 2006, Volume: 12, Issue:1

    Topics: Cardiac Surgical Procedures; Cardiotonic Agents; Child; Child, Preschool; Disseminated Intravascular

2006
Prognostic value of plasma N-terminal pro-brain natriuretic peptide in children with congenital heart defects and open-heart surgery.
    The Journal of pediatrics, 2006, Volume: 148, Issue:3

    Topics: Biomarkers; Cardiopulmonary Bypass; Cardiotonic Agents; Child; Child, Preschool; Heart Defects, Cong

2006
Relevance of the measurement of the concentration of lactate in the serum subsequent to the Fontan procedure in small children.
    Cardiology in the young, 2006, Volume: 16, Issue:3

    Topics: Biomarkers; Follow-Up Studies; Fontan Procedure; Heart Defects, Congenital; Humans; Infant; Lactic A

2006
Continuous hemodiafiltration during cardiopulmonary bypass in infants.
    Asian cardiovascular & thoracic annals, 2007, Volume: 15, Issue:5

    Topics: Acid-Base Imbalance; Calcium; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Heart Defects, Co

2007
Myocardial substrates in children with congenital heart disease: relationship to substrate supply, age, growth and desaturation.
    Acta paediatrica (Oslo, Norway : 1992), 2007, Volume: 96, Issue:11

    Topics: 3-Hydroxybutyric Acid; Adolescent; Age Factors; Analysis of Variance; Blood Chemical Analysis; Blood

2007
Fetal stress response to fetal cardiac surgery.
    The Annals of thoracic surgery, 2008, Volume: 85, Issue:5

    Topics: Acid-Base Equilibrium; Animals; beta-Endorphin; Carbon Dioxide; Cardiopulmonary Bypass; Female; Feta

2008
Fetal stress response to fetal cardiac surgery. Invited commentary.
    The Annals of thoracic surgery, 2008, Volume: 85, Issue:5

    Topics: Animals; beta-Endorphin; Cardiopulmonary Bypass; Female; Fetal Distress; Fetoscopy; Heart Defects, C

2008
Positron emission tomography. The technique and its applications to the study of the cardiovascular system.
    Cardiology clinics, 1983, Volume: 1, Issue:3

    Topics: Acetates; Amino Acids; Blood Glucose; Cardiomyopathies; Child; Coronary Circulation; Energy Metaboli

1983
Interpretation of blood lactate measurements in paediatric open-heart surgery and in extracorporeal membrane oxygenation.
    Scandinavian journal of clinical and laboratory investigation, 1995, Volume: 55, Issue:4

    Topics: Cardiac Surgical Procedures; Extracorporeal Membrane Oxygenation; Female; Heart Defects, Congenital;

1995
Alterations in plasma phosphorus, red cell 2,3-diphosphoglycerate and P50 following open heart surgery.
    The Journal of cardiovascular surgery, 1994, Volume: 35, Issue:6

    Topics: 2,3-Diphosphoglycerate; Adenosine Triphosphate; Analysis of Variance; Blood Preservation; Blood Tran

1994
Air travel and adults with cyanotic congenital heart disease.
    Circulation, 1996, Jan-15, Volume: 93, Issue:2

    Topics: 2,3-Diphosphoglycerate; Adolescent; Adult; Aerospace Medicine; Diphosphoglyceric Acids; Female; Hear

1996
[Metabolic alkalosis after heart surgery interventions in childhood].
    Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS, 1995, Volume: 30 Suppl 1

    Topics: Alkalosis; Blood Component Transfusion; Blood Gas Analysis; Child; Child, Preschool; Female; Heart D

1995
Initial postoperative serum lactate levels predict survival in children after open heart surgery.
    Intensive care medicine, 1996, Volume: 22, Issue:12

    Topics: Adolescent; Cardiac Surgical Procedures; Child; Child, Preschool; Heart Defects, Congenital; Humans;

1996
Serum lactate as a predictor of mortality after paediatric cardiac surgery.
    Archives of disease in childhood, 1997, Volume: 77, Issue:3

    Topics: Biomarkers; Child, Preschool; Heart Defects, Congenital; Humans; Infant; Lactic Acid; Postoperative

1997
Changes in whole blood lactate levels during cardiopulmonary bypass for surgery for congenital cardiac disease: an early indicator of morbidity and mortality.
    The Journal of thoracic and cardiovascular surgery, 2000, Volume: 119, Issue:1

    Topics: Adolescent; Adult; Cardiopulmonary Bypass; Child; Child, Preschool; Female; Heart Defects, Congenita

2000
Prenatal diagnosis of congenital heart disease affects preoperative acidosis in the newborn patient.
    The Journal of thoracic and cardiovascular surgery, 2001, Volume: 121, Issue:4

    Topics: Acidosis; Cardiac Surgical Procedures; Female; Fetal Diseases; Gestational Age; Heart Defects, Conge

2001
[Perioperative assessment of blood lactate levels in pediatric heart surgery].
    Masui. The Japanese journal of anesthesiology, 2001, Volume: 50, Issue:7

    Topics: Adolescent; Biomarkers; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Child; Child, Preschool

2001
Lactacidosis in the neonate is minimized by prenatal detection of congenital heart disease.
    Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology, 2002, Volume: 19, Issue:6

    Topics: Acidosis, Lactic; Female; Heart Defects, Congenital; Humans; Hydrogen-Ion Concentration; Infant, New

2002
Chronic hypoxia: a model for cyanotic congenital heart defects.
    The Journal of thoracic and cardiovascular surgery, 2002, Volume: 124, Issue:1

    Topics: Adenosine Triphosphate; Animals; Cardiopulmonary Bypass; Chronic Disease; Cyanosis; Disease Models,

2002
Purines, lactate and phosphate release from child and adult heart during cardioplegic arrest.
    Clinica chimica acta; international journal of clinical chemistry, 1990, Dec-03, Volume: 192, Issue:3

    Topics: Adult; Cardioplegic Solutions; Child; Child, Preschool; Coronary Disease; Heart Arrest, Induced; Hea

1990