lactic acid has been researched along with Heart Defects, Congenital in 87 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Heart Defects, Congenital: Developmental abnormalities involving structures of the heart. These defects are present at birth but may be discovered later in life.
| Excerpt | Relevance | Reference |
|---|---|---|
| " These factors (immaturity, hyperoxia, hypoxia, blood transfusions, intraventricular hemorrhage, apnea, infection, hypercarbia, hypocarbia, patent ductus arteriosus, prostaglandin synthetase inhibitors, vitamin E deficiency, lactic acidosis, prenatal complications, genetic factors) may all be present in an infant." | 4.76 | A reexamination of the role of oxygen in retrolental fibroplasia. ( Dangman, B; Lucey, JF, 1984) |
| "Preoperative MRI examinations showed periventricular leukomalacia (PVL) in 4 patients (16%) and infarct in 2 subjects (8%)." | 2.70 | An MRI study of neurological injury before and after congenital heart surgery. ( Chiavacci, RM; Clancy, RR; Galli, KK; Gaynor, JW; Kurth, CD; Mahle, WT; Montenegro, LM; Nicolson, SC; Spray, TL; Tavani, F; Wernovsky, G; Zimmerman, RA, 2002) |
| "Mean choline levels were higher in CHD compared with controls (CHD 2." | 1.91 | Magnetic Resonance Spectroscopy of Brain Metabolism in Fetuses With Congenital Heart Disease. ( Andescavage, NN; Cheng, JJ; Donofrio, MT; du Plessis, AJ; Gimovsky, AC; Kapse, K; Limperopoulos, C; Pradhan, S; Sharker, Y; Wessel, D, 2023) |
| "Major adverse events (MAE) are unexpected but undesirably frequent after pediatric congenital heart surgery and contribute to poorer outcomes." | 1.62 | Central Venous Oxygen Saturation/Lactate Ratio and Prediction of Major Adverse Events After Pediatric Heart Surgery. ( Carmona, F; Manso, PH; Rocha, VHS, 2021) |
| " The mean lactate half-life was 12." | 1.51 | Lactate clearance in infants undergoing surgery for congenital heart disease. ( Albinni, S; Berkia, I; Bojan, M; Desplanque, L; Hamaide-Defrocourt, F; Tourneur, T, 2019) |
| "In those with bacterial infection, procalcitonin was elevated on postoperative days 1-3 and the last measurement prior to event compared with those without bacterial infection." | 1.51 | Procalcitonin and Other Common Biomarkers Do Not Reliably Identify Patients at Risk for Bacterial Infection After Congenital Heart Surgery. ( Baines, P; Carrol, E; Chesters, C; D'Souza, S; Downey, C; Guhadasan, R; Jennings, R; Lane, S; Paulus, S; Siner, S; Thorburn, K, 2019) |
| "Survival of children having cardiac arrest refractory to conventional cardiopulmonary resuscitation (CPR) is very poor." | 1.40 | Results of rapid-response extracorporeal cardiopulmonary resuscitation in children with refractory cardiac arrest following cardiac surgery. ( Al-Ahmadi, M; Al-Halees, Z; Alsoufi, B; Awan, A; Guechef, A; Kalloghlian, A; Manlhiot, C; McCrindle, BW, 2014) |
| "Low cardiac output syndrome is common after paediatric cardiac surgery." | 1.38 | Serum cortisol concentration with exploratory cut-off values do not predict the effects of hydrocortisone administration in children with low cardiac output after cardiac surgery. ( de Jonge, E; Hazekamp, MG; Hogenbirk, K; Roest, AA; van Brempt, R; Verweij, EJ, 2012) |
| "Levosimendan produced an increase in cΔHbD (p < 0." | 1.37 | Acute effects of levosimendan on cerebral and systemic perfusion and oxygenation in newborns: an observational study. ( Bravo, MC; Bravo, Mdel C; Cabañas, F; López, P; Pellicer, A; Pérez-Fernández, E; Pérez-Rodríguez, J; Quero, J, 2011) |
| "Levosimendan is a calcium-sensitizing agent with effective inotropic properties." | 1.35 | First experiences with intraoperative Levosimendan in pediatric cardiac surgery. ( Boethig, D; Goerler, H; Huber, D; Osthaus, WA; Sasse, M; Sümpelmann, R; Winterhalter, M, 2009) |
| "Congenital heart disease is the leading cause of death in the first year after birth." | 1.31 | Prenatal diagnosis of congenital heart disease affects preoperative acidosis in the newborn patient. ( Bennink, GB; Brenner, JI; Copel, JA; Hitchcock, JF; Kleinman, CS; Lisowski, LA; Meijboom, EJ; Stoutenbeek, P; Verheijen, PM, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (9.20) | 18.7374 |
| 1990's | 7 (8.05) | 18.2507 |
| 2000's | 28 (32.18) | 29.6817 |
| 2010's | 39 (44.83) | 24.3611 |
| 2020's | 5 (5.75) | 2.80 |
| Authors | Studies |
|---|---|
| Rocha, VHS | 1 |
| Manso, PH | 2 |
| Carmona, F | 2 |
| Xia, Y | 1 |
| Liu, M | 1 |
| Fan, J | 1 |
| Qiu, Y | 1 |
| Zhang, X | 1 |
| Zheng, Z | 1 |
| Shi, S | 1 |
| Andescavage, NN | 1 |
| Pradhan, S | 1 |
| Gimovsky, AC | 1 |
| Kapse, K | 1 |
| Donofrio, MT | 2 |
| Cheng, JJ | 1 |
| Sharker, Y | 1 |
| Wessel, D | 1 |
| du Plessis, AJ | 2 |
| Limperopoulos, C | 2 |
| Farias, JS | 1 |
| Villarreal, EG | 1 |
| Flores, S | 1 |
| Mastropietro, CW | 1 |
| Vogel, M | 1 |
| Schulz, K | 1 |
| Culichia, C | 1 |
| Iliopoulos, ID | 1 |
| Bronicki, RA | 1 |
| Loomba, RS | 1 |
| Jonas, MC | 1 |
| Caneo, LF | 1 |
| Turquetto, ALR | 1 |
| Jatene, MB | 1 |
| Lu, Z | 1 |
| Wang, X | 1 |
| Yang, J | 2 |
| Li, S | 1 |
| Yan, J | 1 |
| Sughimoto, K | 1 |
| Kohira, S | 1 |
| Hayashi, H | 1 |
| Torii, S | 1 |
| Kitamura, T | 1 |
| Horai, T | 1 |
| Miyaji, K | 1 |
| Desplanque, L | 1 |
| Hamaide-Defrocourt, F | 1 |
| Berkia, I | 1 |
| Tourneur, T | 1 |
| Albinni, S | 1 |
| Bojan, M | 2 |
| D'Souza, S | 1 |
| Guhadasan, R | 1 |
| Jennings, R | 1 |
| Siner, S | 1 |
| Paulus, S | 1 |
| Thorburn, K | 1 |
| Chesters, C | 1 |
| Downey, C | 1 |
| Baines, P | 1 |
| Lane, S | 1 |
| Carrol, E | 1 |
| Yang, L | 1 |
| Ye, L | 1 |
| Fan, Y | 1 |
| He, W | 1 |
| Zong, Q | 1 |
| Zhao, W | 1 |
| Lin, R | 1 |
| Bonaveglio, E | 1 |
| Dolcino, A | 1 |
| Mirabile, C | 1 |
| Veeram Reddy, SR | 2 |
| Welch, TR | 3 |
| Wang, J | 3 |
| Bernstein, F | 1 |
| Richardson, JA | 2 |
| Forbess, JM | 2 |
| Nugent, AW | 2 |
| Alsoufi, B | 1 |
| Awan, A | 1 |
| Manlhiot, C | 1 |
| Guechef, A | 1 |
| Al-Halees, Z | 1 |
| Al-Ahmadi, M | 1 |
| McCrindle, BW | 1 |
| Kalloghlian, A | 1 |
| Friedland-Little, JM | 1 |
| Hirsch-Romano, JC | 1 |
| Yu, S | 2 |
| Donohue, JE | 1 |
| Canada, CE | 1 |
| Soraya, P | 1 |
| Aiyagari, R | 1 |
| Schumacher, KR | 1 |
| Reichel, RA | 1 |
| Vlasic, JR | 1 |
| Donohue, J | 1 |
| Gajarski, RJ | 1 |
| Charpie, JR | 2 |
| Tume, LN | 1 |
| Arnold, P | 1 |
| Miao, N | 1 |
| Du, Z | 1 |
| Liu, W | 1 |
| Ni, H | 1 |
| Xing, J | 1 |
| Yang, X | 1 |
| Xu, B | 1 |
| Hou, X | 1 |
| Alton, GY | 2 |
| Taghados, S | 1 |
| Joffe, AR | 3 |
| Robertson, CM | 3 |
| Dinu, I | 1 |
| Riegel, M | 1 |
| Goodfriend, AC | 1 |
| Barker, G | 1 |
| Ginther, R | 1 |
| Riegel, MS | 1 |
| Reddy, SV | 1 |
| Nugent, A | 1 |
| Forbess, J | 1 |
| McCrossan, BA | 1 |
| McMahon, CJ | 1 |
| Walsh, KP | 1 |
| Aly, SA | 1 |
| Zurakowski, D | 2 |
| Glass, P | 1 |
| Skurow-Todd, K | 1 |
| Jonas, RA | 1 |
| Harbison, AL | 1 |
| Votava-Smith, JK | 1 |
| Del Castillo, S | 1 |
| Kumar, SR | 1 |
| Lee, V | 1 |
| Schmithorst, V | 1 |
| Lai, HA | 1 |
| O'Neil, S | 1 |
| Bluml, S | 1 |
| Paquette, L | 1 |
| Panigrahy, A | 1 |
| Osthaus, WA | 1 |
| Boethig, D | 1 |
| Winterhalter, M | 1 |
| Huber, D | 1 |
| Goerler, H | 1 |
| Sasse, M | 1 |
| Sümpelmann, R | 1 |
| Li, P | 1 |
| Yuan, D | 1 |
| Luo, WJ | 1 |
| Tworetzky, W | 1 |
| McElhinney, DB | 1 |
| Newburger, JW | 3 |
| Brown, DW | 1 |
| Robertson, RL | 1 |
| Guizard, N | 1 |
| McGrath, E | 2 |
| Geva, J | 1 |
| Annese, D | 1 |
| Dunbar-Masterson, C | 1 |
| Trainor, B | 1 |
| Laussen, PC | 4 |
| Rossi, AF | 4 |
| Lopez, L | 1 |
| Dobrolet, N | 1 |
| Khan, D | 2 |
| Bolivar, J | 2 |
| Molina Hazan, V | 1 |
| Gonen, Y | 1 |
| Vardi, A | 1 |
| Keidan, I | 1 |
| Mishali, D | 1 |
| Rubinshtein, M | 1 |
| Yakov, Y | 1 |
| Paret, G | 2 |
| Verheijen, PM | 3 |
| Lisowski, LA | 3 |
| Wassink, S | 1 |
| Visser, GH | 1 |
| Meijboom, EJ | 4 |
| Allan, CK | 1 |
| Elder, J | 1 |
| Psoinos, C | 1 |
| del Nido, PJ | 1 |
| Wypij, D | 1 |
| McGowan, FX | 2 |
| Bravo, MC | 1 |
| Bravo, Mdel C | 1 |
| López, P | 1 |
| Cabañas, F | 1 |
| Pérez-Rodríguez, J | 1 |
| Pérez-Fernández, E | 1 |
| Quero, J | 1 |
| Pellicer, A | 1 |
| Golab, HD | 2 |
| Scohy, TV | 1 |
| de Jong, PL | 1 |
| Kissler, J | 1 |
| Takkenberg, JJ | 2 |
| Bogers, AJ | 2 |
| Polimenakos, AC | 1 |
| Wojtyla, P | 1 |
| Smith, PJ | 1 |
| Rizzo, V | 1 |
| Nater, M | 1 |
| El Zein, CF | 1 |
| Ilbawi, MN | 1 |
| Boks, RH | 1 |
| Algra, SO | 2 |
| Kornmann, VN | 1 |
| van der Tweel, I | 2 |
| Schouten, AN | 2 |
| Jansen, NJ | 2 |
| Haas, F | 2 |
| Dumaresq, DM | 1 |
| Vasconcelos, RC | 1 |
| Guimarães, SB | 1 |
| Cavalcante, SL | 1 |
| Garcia, JH | 1 |
| Vasconcelos, AR | 1 |
| Maarslet, L | 1 |
| Møller, MB | 1 |
| Dall, R | 1 |
| Hjortholm, K | 1 |
| Ravn, H | 1 |
| Gupta, P | 1 |
| Jines, P | 1 |
| Gossett, JM | 1 |
| Maurille, M | 1 |
| Hanley, FL | 1 |
| Reddy, VM | 1 |
| Miyake, CY | 1 |
| Roth, SJ | 2 |
| van Oeveren, W | 1 |
| Schoof, PH | 1 |
| Mehta, NM | 1 |
| Costello, JM | 1 |
| Bechard, LJ | 1 |
| Johnson, VM | 1 |
| Duggan, CP | 1 |
| Molina-Hazan, V | 1 |
| Verweij, EJ | 1 |
| Hogenbirk, K | 1 |
| Roest, AA | 1 |
| van Brempt, R | 1 |
| Hazekamp, MG | 1 |
| de Jonge, E | 1 |
| Amirnovin, R | 1 |
| Keller, RL | 1 |
| Herrera, C | 1 |
| Hsu, JH | 1 |
| Datar, S | 1 |
| Karl, TR | 1 |
| Adatia, I | 1 |
| Oishi, P | 1 |
| Fineman, JR | 1 |
| Mackie, AS | 1 |
| Dinu, IA | 1 |
| Nishibe, S | 1 |
| Tsujita, M | 1 |
| Park, SJ | 1 |
| Kim, HS | 1 |
| Byon, HJ | 1 |
| Kim, CS | 1 |
| Cheong, IY | 1 |
| Kim, JT | 1 |
| Mahle, WT | 1 |
| Tavani, F | 1 |
| Zimmerman, RA | 1 |
| Nicolson, SC | 1 |
| Galli, KK | 1 |
| Gaynor, JW | 1 |
| Clancy, RR | 1 |
| Montenegro, LM | 1 |
| Spray, TL | 2 |
| Chiavacci, RM | 1 |
| Wernovsky, G | 2 |
| Kurth, CD | 1 |
| Hoffman, TM | 1 |
| Atz, AM | 1 |
| Kulik, TJ | 2 |
| Nelson, DP | 1 |
| Chang, AC | 1 |
| Bailey, JM | 1 |
| Akbary, A | 1 |
| Kocsis, JF | 1 |
| Kaczmarek, R | 1 |
| Wessel, DL | 2 |
| HOLMGREN, A | 1 |
| STROM, G | 1 |
| CASTELLO, D | 1 |
| MADON, E | 1 |
| GREENE, NM | 1 |
| TALNER, NS | 1 |
| LEVISON, H | 1 |
| SWYER, PR | 1 |
| JOVINO, R | 1 |
| MASTRANDREA, F | 1 |
| MUSELLA, S | 1 |
| HAVEL, RJ | 1 |
| WATKINS, E | 1 |
| Ishida, R | 1 |
| Oiwa, H | 1 |
| Honda, K | 1 |
| Imamura, K | 1 |
| Nonaka, T | 1 |
| Sudo, K | 1 |
| Ootaki, Y | 1 |
| Yamaguchi, M | 2 |
| Yoshimura, N | 2 |
| Oka, S | 1 |
| Yoshida, M | 2 |
| Hasegawa, T | 1 |
| Modi, P | 1 |
| Suleiman, MS | 1 |
| Reeves, B | 1 |
| Pawade, A | 1 |
| Parry, AJ | 1 |
| Angelini, GD | 1 |
| Caputo, M | 1 |
| Gessler, P | 2 |
| Pretre, R | 1 |
| Hohl, V | 1 |
| Rousson, V | 2 |
| Fischer, J | 1 |
| Dahinden, C | 1 |
| Khan, DM | 1 |
| Hannan, R | 1 |
| Zaidenweber, M | 1 |
| Burke, R | 1 |
| Durward, A | 1 |
| Tibby, SM | 2 |
| Skellett, S | 1 |
| Austin, C | 1 |
| Anderson, D | 2 |
| Murdoch, IA | 2 |
| Ohuchi, H | 1 |
| Hayashi, T | 1 |
| Yamada, O | 1 |
| Echigo, S | 1 |
| Cheung, PY | 1 |
| Chui, N | 1 |
| Rebeyka, IM | 1 |
| Hannan, RL | 2 |
| Ybarra, MA | 1 |
| White, JA | 1 |
| Ojito, JW | 1 |
| Burke, RP | 1 |
| Hamamoto, M | 2 |
| Imanaka, H | 2 |
| Kagisaki, K | 1 |
| Yagihara, T | 2 |
| Kitamura, S | 1 |
| Nishimura, M | 1 |
| Baslaim, G | 1 |
| Bashore, J | 1 |
| Al-Malki, F | 1 |
| Jamjoom, A | 1 |
| Knirsch, W | 1 |
| Schmitt, B | 1 |
| von Eckardstein, A | 1 |
| Uemura, H | 1 |
| Oshima, Y | 1 |
| Murakami, H | 1 |
| Matsuhisa, H | 1 |
| Amark, K | 1 |
| Ekroth, R | 1 |
| Nilsson, K | 1 |
| Sunnegårdh, J | 1 |
| Söderberg, B | 1 |
| Lam, CT | 1 |
| Sharma, S | 1 |
| Baker, RS | 1 |
| Hilshorst, J | 1 |
| Lombardi, J | 1 |
| Clark, KE | 1 |
| Eghtesady, P | 1 |
| Fenton, KN | 1 |
| Schelbert, HR | 1 |
| Benson, L | 1 |
| Schwaiger, M | 1 |
| Perloff, J | 1 |
| Lucey, JF | 1 |
| Dangman, B | 1 |
| Toffaletti, J | 1 |
| Hansell, D | 1 |
| Hasan, RA | 1 |
| Sarnaik, AP | 1 |
| Meert, KL | 1 |
| Dabbagh, S | 1 |
| Simpson, P | 1 |
| Makimi, M | 1 |
| Harinck, E | 1 |
| Hutter, PA | 1 |
| Hoorntje, TM | 1 |
| Simons, M | 1 |
| Benatar, AA | 1 |
| Fischer, JC | 1 |
| de Bruijn, D | 1 |
| Schranz, D | 1 |
| Schnittker, C | 1 |
| Michel-Behnke, I | 1 |
| Schmid, FX | 1 |
| Wippermann, CF | 1 |
| Siegel, LB | 1 |
| Dalton, HJ | 1 |
| Hertzog, JH | 1 |
| Hopkins, RA | 1 |
| Hauser, GJ | 1 |
| Hatherill, M | 1 |
| Sajjanhar, T | 1 |
| Champion, MP | 1 |
| Marsh, MJ | 1 |
| Munoz, R | 1 |
| Palacio, G | 1 |
| Zienko, L | 1 |
| Piercey, G | 1 |
| Dekeon, MK | 1 |
| Goldberg, CS | 1 |
| Mosca, RS | 1 |
| Bove, EL | 1 |
| Stoutenbeek, P | 2 |
| Hitchcock, JF | 2 |
| Brenner, JI | 1 |
| Copel, JA | 1 |
| Kleinman, CS | 1 |
| Bennink, GB | 2 |
| Shime, N | 1 |
| Kageyama, K | 1 |
| Ashida, H | 1 |
| Ueda, M | 1 |
| Kitamura, Y | 1 |
| Tanaka, Y | 1 |
| Corno, AF | 1 |
| Milano, G | 1 |
| Samaja, M | 1 |
| Tozzi, P | 1 |
| von Segesser, LK | 1 |
| Smolenski, RT | 1 |
| Swierczyński, J | 1 |
| Narkiewicz, M | 1 |
| Zydowo, MM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Newborn Project: A Prospective Observational Study Examining the Oxygenation of Brain Tissue During General Anesthesia Using Near Infrared Spectroscopy Technology[NCT03057587] | 0 participants (Actual) | Observational | 2017-05-12 | Withdrawn (stopped due to The research never began.) | |||
| Perioperative Levosimendan Administration in Neonates With Transposition of the Great Arteries: Randomized Controlled Trial[NCT01120106] | Phase 2 | 63 participants (Actual) | Interventional | 2009-01-31 | Completed | ||
| Fetal Cerebrovascular Autoregulation in Congenital Heart Disease and Association With Neonatal Neurobehavior[NCT05767385] | Phase 2/Phase 3 | 150 participants (Anticipated) | Interventional | 2021-12-17 | Recruiting | ||
| Removal of Cytokines in Patients Undergoing Cardiac Surgery With CPB (The REMOTE Study)[NCT03104179] | 80 participants (Anticipated) | Interventional | 2017-05-31 | Not yet recruiting | |||
| Phase I Study of Two Inodilators in Neonates Undergoing Cardiovascular Surgery[NCT01576094] | Phase 1/Phase 2 | 20 participants (Actual) | Interventional | 2009-11-30 | Completed | ||
| Albumin vs. Plasma for PEdiAtric pRiming Trial[NCT02738190] | Phase 4 | 80 participants (Actual) | Interventional | 2015-01-31 | Completed | ||
| Randomized Controlled Trial on Deep Hypothermic Circulatory Arrest Versus Antegrade Cerebral Perfusion During Neonatal Cardiac Surgery[NCT01032876] | 37 participants (Actual) | Interventional | 2009-01-31 | Completed | |||
| Cerebral Anatomy, Hemodynamics and Metabolism In Single Ventricles: Relationship to Neurodevelopment[NCT02919956] | 119 participants (Actual) | Observational | 2016-04-30 | Active, not recruiting | |||
| International Study of Cerebral Oxygenation and Electrical Activity During Major Neonatal Surgery[NCT05673499] | 900 participants (Anticipated) | Observational | 2022-08-12 | Recruiting | |||
| Autologous Cord Blood Cells for Patients With HLHS: Phase I Study of Feasibility and Safety[NCT01445041] | Phase 1 | 7 participants (Actual) | Interventional | 2011-09-01 | Terminated (stopped due to Funding Period Ended) | ||
| STeroids to REduce Systemic Inflammation After Infant Heart Surgery (STRESS)[NCT03229538] | Phase 3 | 1,263 participants (Actual) | Interventional | 2017-10-18 | Completed | ||
| Phase 2 Prospective, Randomized, Double-Blind Pilot Study on Cardiac Output Following Corrective Open Heart Surgery in Children Less Than One Year: Use of Levosimendan Versus Milrinone.[NCT00549107] | Phase 2 | 40 participants (Anticipated) | Interventional | 2007-09-30 | Recruiting | ||
| Preoperative Corticosteroid Therapy in Neonates Undergoing Cardiopulmonary Bypass[NCT00934843] | 77 participants (Actual) | Interventional | 2007-03-31 | Completed | |||
| Use of the Cardioprotectant Dexrazoxane During Congenital Heart Surgery: Proposal for Pilot Investigation[NCT02519335] | Phase 1 | 12 participants (Actual) | Interventional | 2014-09-30 | Terminated (stopped due to PI no longer at this facility) | ||
| 2- Inhaled Milrinone Prevents the Increase in Pulmonary Artery Pressure After CPB[NCT00819377] | Phase 2 | 124 participants (Anticipated) | Interventional | 2009-02-28 | Completed | ||
| Use of the Cardioprotectant Dexrazoxane During Congenital Heart Surgery[NCT04997291] | Phase 1 | 12 participants (Anticipated) | Interventional | 2021-04-09 | Recruiting | ||
| Early Lactate-Directed Therapy on the ICU: A Randomized Controlled Trial[NCT00270673] | Phase 3 | 350 participants (Anticipated) | Interventional | 2006-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Calculated as discharge date minus surgery date. (NCT03229538)
Timeframe: Until hospital discharge, up to 4 months
| Intervention | Participants (Count of Participants) |
|---|---|
| Methylprednisolone Arm | 18 |
| Placebo Arm | 29 |
(NCT03229538)
Timeframe: Until hospital discharge, up to 4 months
| Intervention | Participants (Count of Participants) |
|---|---|
| Methylprednisolone Arm | 237 |
| Placebo Arm | 264 |
The 7 highest global ranking categories range from 91 (postoperative length of hospital stay > 90 days) to 97 (operative mortality). (NCT03229538)
Timeframe: Until hospital discharge, up to 4 months
| Intervention | Participants (Count of Participants) |
|---|---|
| Methylprednisolone Arm | 103 |
| Placebo Arm | 122 |
(NCT03229538)
Timeframe: up to 30 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Methylprednisolone Arm | 12 |
| Placebo Arm | 17 |
(NCT03229538)
Timeframe: Until hospital discharge, up to 4 months
| Intervention | Participants (Count of Participants) |
|---|---|
| Methylprednisolone Arm | 31 |
| Placebo Arm | 24 |
"Based upon the STS-CHSD registry defined cardiac dysfunction resulting in low cardiac output complication variable." (NCT03229538)
Timeframe: Until hospital discharge, up to 4 months
| Intervention | Participants (Count of Participants) |
|---|---|
| Methylprednisolone Arm | 31 |
| Placebo Arm | 37 |
(NCT03229538)
Timeframe: Until hospital discharge, up to 4 months
| Intervention | Participants (Count of Participants) |
|---|---|
| Methylprednisolone Arm | 41 |
| Placebo Arm | 51 |
The inotropic score was calculated by the equation using drug dosages in micrograms/kg/min, (dopamine+dobutamine) + (milrinonex10) + (epinephrinex100) and recorded hourly upon arrival to the ICUthrough 36 hours postoperatively. The highest score during this timeframe was recorded. This score converts dosages of commonly used inotropic medications into a score. The higher the score the more inotropic medications required. The minimum score would be zero indicating no inotropic medications were used. There is no maximum score. (NCT00934843)
Timeframe: over the first 36 hours after surgery
| Intervention | Scores on a scale (Mean) |
|---|---|
| MP Single Dose | 14.4 |
| MP Two Dose | 15.0 |
Number of participants who died of any cause between 36 hours and 30 days following cardiac surgery (NCT00934843)
Timeframe: at 36 hours and 30 days
| Intervention | participants (Number) |
|---|---|
| MP Single Dose | 1 |
| MP Two Dose | 0 |
The presence of low cardiac output syndrome (LCOS) was defined by the same definition used in the PRIMACORP study (Hoffman TM.et.al. Circulation 2003 107:996-1002). Specifically, if there were clinical signs and symptoms of low cardiac output (e.g., tachycardia, oliguria, cold extremities, cardiac arrest, etc.) which required one or more of the following interventions: mechanical circulatory support, the escalation of existing pharmacological circulatory support to >100% over baseline, or the initiation of new pharmacological circulatory support. (NCT00934843)
Timeframe: 36 hours
| Intervention | participants (Number) |
|---|---|
| MP Single Dose | 17 |
| MP Two Dose | 15 |
Total urine output in mL over the first 36 hours after cardiac surgery (NCT00934843)
Timeframe: over 36 hours
| Intervention | mL (Mean) |
|---|---|
| MP Single Dose | 498 |
| MP Two Dose | 453 |
Total amount of all fluids in and out during the first 36 hours postoperatively in mL. (NCT00934843)
Timeframe: over 36 hours
| Intervention | mL (Mean) | |
|---|---|---|
| Total Fluid in at 36 hr | Total Fluid out at 36 hr | |
| MP Single Dose | 575 | 600 |
| MP Two Dose | 586 | 558 |
2 reviews available for lactic acid and Heart Defects, Congenital
| Article | Year |
|---|---|
Effects of Vasopressin Infusion After Pediatric Cardiac Surgery: A Meta-analysis.
Topics: Blood Pressure; Cardiac Surgical Procedures; Child, Preschool; Female; Heart Defects, Congenital; He | 2021 |
A reexamination of the role of oxygen in retrolental fibroplasia.
Topics: Anencephaly; Apnea; Carbon Dioxide; Cerebral Hemorrhage; Ductus Arteriosus, Patent; Exchange Transfu | 1984 |
11 trials available for lactic acid and Heart Defects, Congenital
| Article | Year |
|---|---|
Vasopressin in Vasodilatory Shock for Both Left and Right Heart Anomalous Pediatric Patients After Cardiac Surgery.
Topics: Adolescent; Blood Pressure; Cardiopulmonary Bypass; Child; Child, Preschool; Female; Heart Defects, | 2018 |
Comparison of low molecular weight hydroxyethyl starch and human albumin as priming solutions in children undergoing cardiac surgery.
Topics: Blood Glucose; Cardiopulmonary Bypass; Creatinine; Female; Heart Defects, Congenital; Hematocrit; Hu | 2014 |
Relevance of colloid oncotic pressure regulation during neonatal and infant cardiopulmonary bypass: a prospective randomized study.
Topics: Body Weight; Cardiopulmonary Bypass; Colloids; Double-Blind Method; Drug Administration Schedule; Fe | 2011 |
Metabolic and oxidative effects of sevoflurane and propofol in children undergoing surgery for congenital heart disease.
Topics: Adolescent; Anesthetics, Inhalation; Anesthetics, Intravenous; Child; Child, Preschool; Female; Glut | 2011 |
Low-flow antegrade cerebral perfusion attenuates early renal and intestinal injury during neonatal aortic arch reconstruction.
Topics: Aorta, Thoracic; Biomarkers; Cerebrovascular Circulation; Circulatory Arrest, Deep Hypothermia Induc | 2012 |
An MRI study of neurological injury before and after congenital heart surgery.
Topics: Brain; Brain Chemistry; Cardiopulmonary Bypass; Cerebral Infarction; Cerebrovascular Disorders; Coho | 2002 |
An MRI study of neurological injury before and after congenital heart surgery.
Topics: Brain; Brain Chemistry; Cardiopulmonary Bypass; Cerebral Infarction; Cerebrovascular Disorders; Coho | 2002 |
An MRI study of neurological injury before and after congenital heart surgery.
Topics: Brain; Brain Chemistry; Cardiopulmonary Bypass; Cerebral Infarction; Cerebrovascular Disorders; Coho | 2002 |
An MRI study of neurological injury before and after congenital heart surgery.
Topics: Brain; Brain Chemistry; Cardiopulmonary Bypass; Cerebral Infarction; Cerebrovascular Disorders; Coho | 2002 |
An MRI study of neurological injury before and after congenital heart surgery.
Topics: Brain; Brain Chemistry; Cardiopulmonary Bypass; Cerebral Infarction; Cerebrovascular Disorders; Coho | 2002 |
An MRI study of neurological injury before and after congenital heart surgery.
Topics: Brain; Brain Chemistry; Cardiopulmonary Bypass; Cerebral Infarction; Cerebrovascular Disorders; Coho | 2002 |
An MRI study of neurological injury before and after congenital heart surgery.
Topics: Brain; Brain Chemistry; Cardiopulmonary Bypass; Cerebral Infarction; Cerebrovascular Disorders; Coho | 2002 |
An MRI study of neurological injury before and after congenital heart surgery.
Topics: Brain; Brain Chemistry; Cardiopulmonary Bypass; Cerebral Infarction; Cerebrovascular Disorders; Coho | 2002 |
An MRI study of neurological injury before and after congenital heart surgery.
Topics: Brain; Brain Chemistry; Cardiopulmonary Bypass; Cerebral Infarction; Cerebrovascular Disorders; Coho | 2002 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease.
Topics: Blood Pressure; Cardiac Output, Low; Child; Child, Preschool; Double-Blind Method; Endpoint Determin | 2003 |
Myocardial metabolic changes during pediatric cardiac surgery: a randomized study of 3 cardioplegic techniques.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Biomarkers; Cardiac Surgical Procedures; Child; Child | 2004 |
CXC-chemokine stimulation of neutrophils correlates with plasma levels of myeloperoxidase and lactoferrin and contributes to clinical outcome after pediatric cardiac surgery.
Topics: Chemokine CCL2; Chemokines, CXC; Child; Child, Preschool; Down-Regulation; Heart Defects, Congenital | 2004 |
Patterns of lactate values after congenital heart surgery and timing of cardiopulmonary support.
Topics: Cardiopulmonary Resuscitation; Heart Arrest; Heart Defects, Congenital; Humans; Lactic Acid; Postope | 2005 |
Serial blood lactate measurements predict early outcome after neonatal repair or palliation for complex congenital heart disease.
Topics: Extracorporeal Membrane Oxygenation; Heart Defects, Congenital; Humans; Infant, Newborn; Lactic Acid | 2000 |
74 other studies available for lactic acid and Heart Defects, Congenital
| Article | Year |
|---|---|
Central Venous Oxygen Saturation/Lactate Ratio and Prediction of Major Adverse Events After Pediatric Heart Surgery.
Topics: Cardiac Surgical Procedures; Child; Heart Defects, Congenital; Humans; Infant; Lactic Acid; Oxygen; | 2021 |
Risk factors of postoperative neurodevelopmental abnormalities in neonates with critical congenital heart disease.
Topics: Child; Heart Defects, Congenital; Humans; Infant; Infant, Newborn; Lactic Acid; Prognosis; Retrospec | 2023 |
Magnetic Resonance Spectroscopy of Brain Metabolism in Fetuses With Congenital Heart Disease.
Topics: Brain; Choline; Female; Fetus; Heart Defects, Congenital; Humans; Infant; Lactic Acid; Magnetic Reso | 2023 |
Risk factors for death or mechanical ventilation time after bidirectional cavopulmonary anastomosis in a developing country.
Topics: Developing Countries; Fontan Procedure; Heart Defects, Congenital; Hospital Mortality; Humans; Infan | 2022 |
Markers of peripheral perfusion during high-flow regional cerebral perfusion for aortic arch repair.
Topics: Age Factors; Aorta, Thoracic; Biomarkers; Blood Flow Velocity; Cardiopulmonary Bypass; Cerebrovascul | 2018 |
Lactate clearance in infants undergoing surgery for congenital heart disease.
Topics: Cardiac Surgical Procedures; Cardiopulmonary Bypass; Erythrocyte Transfusion; Half-Life; Heart Defec | 2019 |
Procalcitonin and Other Common Biomarkers Do Not Reliably Identify Patients at Risk for Bacterial Infection After Congenital Heart Surgery.
Topics: Adolescent; Bacterial Infections; Biomarkers; Blood Platelets; C-Reactive Protein; Cardiac Surgical | 2019 |
Outcomes following venoarterial extracorporeal membrane oxygenation in children with refractory cardiogenic disease.
Topics: Child; Child, Preschool; Extracorporeal Membrane Oxygenation; Female; Heart Defects, Congenital; Hos | 2019 |
Somatic and cerebral near infrared spectroscopy for the monitoring of perfusion during neonatal cardiopulmonary bypass.
Topics: Biomarkers; Brain; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cerebrovascular Circulation; | 2019 |
A novel biodegradable stent applicable for use in congenital heart disease: bench testing and feasibility results in a rabbit model.
Topics: Absorbable Implants; Animals; Arterial Occlusive Diseases; Arteritis; Cardiac Catheterization; Cathe | 2014 |
Results of rapid-response extracorporeal cardiopulmonary resuscitation in children with refractory cardiac arrest following cardiac surgery.
Topics: Cardiac Surgical Procedures; Cardiopulmonary Resuscitation; Child; Child, Preschool; Extracorporeal | 2014 |
Risk factors for requiring extracorporeal membrane oxygenation support after a Norwood operation.
Topics: Area Under Curve; Biomarkers; Birth Weight; Cardiopulmonary Bypass; Chi-Square Distribution; Extraco | 2014 |
Rate of increase in serum lactate level risk-stratifies infants after surgery for congenital heart disease.
Topics: Acidosis, Lactic; Age Factors; Area Under Curve; Biomarkers; Cardiac Surgical Procedures; Cardiopulm | 2014 |
Near-infrared spectroscopy after high-risk congenital heart surgery in the paediatric intensive care unit.
Topics: Cardiac Surgical Procedures; England; Female; Heart Defects, Congenital; Humans; Infant; Infant, New | 2015 |
Prediction of preschool functional abilities after early complex cardiac surgery.
Topics: Activities of Daily Living; Canada; Cardiac Surgical Procedures; Child, Preschool; Female; Heart Def | 2015 |
A novel design biodegradable stent for use in congenital heart disease: mid-term results in rabbit descending aorta.
Topics: Absorbable Implants; Animals; Aorta, Thoracic; Aortic Diseases; Aortography; Arterial Occlusive Dise | 2015 |
Novel bioresorbable stent coating for drug release in congenital heart disease applications.
Topics: Absorbable Implants; Animals; Coated Materials, Biocompatible; Dexamethasone; Drug Liberation; Drug- | 2015 |
First reported use of drug-eluting bioabsorbable vascular scaffold in congenital heart disease.
Topics: Absorbable Implants; Angioplasty, Balloon; Cardiovascular Agents; Child; Coated Materials, Biocompat | 2016 |
Cerebral tissue oxygenation index and lactate at 24 hours postoperative predict survival and neurodevelopmental outcome after neonatal cardiac surgery.
Topics: Age Factors; Area Under Curve; Biomarkers; Brain; Cardiac Surgical Procedures; Cerebrovascular Circu | 2017 |
Clinical Factors Associated with Cerebral Metabolism in Term Neonates with Congenital Heart Disease.
Topics: Aspartic Acid; Biomarkers; Birth Weight; Brain; Cohort Studies; Female; Gestational Age; Glutamine; | 2017 |
First experiences with intraoperative Levosimendan in pediatric cardiac surgery.
Topics: Cardiac Output; Cardiac Output, Low; Cardiac Surgical Procedures; Cardiotonic Agents; Heart; Heart D | 2009 |
[Dynamic monitoring of arterial blood lactic acid in the prognosis of heart operation].
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Female; Heart Defects, Congenital; Humans; Infant; | 2008 |
Brain volume and metabolism in fetuses with congenital heart disease: evaluation with quantitative magnetic resonance imaging and spectroscopy.
Topics: Aspartic Acid; Brain; Choline; Female; Gestational Age; Heart Defects, Congenital; Humans; Imaging, | 2010 |
Hyperlactatemia in neonates admitted to the cardiac intensive care unit with critical heart disease.
Topics: Acidosis, Lactic; Acute Disease; Heart Defects, Congenital; Humans; Infant, Newborn; Intensive Care | 2010 |
Blood lactate levels differ significantly between surviving and nonsurviving patients within the same risk-adjusted Classification for Congenital Heart Surgery (RACHS-1) group after pediatric cardiac surgery.
Topics: Adolescent; Child; Child, Preschool; Female; Heart Defects, Congenital; Humans; Infant; Infant, Newb | 2010 |
Preoperative acidosis and infant development following surgery for congenital heart disease.
Topics: Acidosis, Lactic; Cardiopulmonary Bypass; Cohort Studies; Developmental Disabilities; Heart Arrest, | 2010 |
The relationship between inflammatory activation and clinical outcome after infant cardiopulmonary bypass.
Topics: Biomarkers; Boston; C-Reactive Protein; Cardiopulmonary Bypass; Heart Defects, Congenital; Hematocri | 2010 |
Acute effects of levosimendan on cerebral and systemic perfusion and oxygenation in newborns: an observational study.
Topics: Blood Pressure; Cardiac Output, Low; Cardiotonic Agents; Cerebrovascular Circulation; Heart Defects, | 2011 |
Post-cardiotomy extracorporeal cardiopulmonary resuscitation in neonates with complex single ventricle: analysis of outcomes.
Topics: Cardiopulmonary Resuscitation; Epidemiologic Methods; Extracorporeal Membrane Oxygenation; Female; H | 2011 |
Washing of irradiated red blood cells in paediatric cardiopulmonary bypass: is it clinically useful? A retrospective audit.
Topics: Blood Preservation; Blood Specimen Collection; Cardiopulmonary Bypass; Erythrocyte Transfusion; Eryt | 2012 |
Increasing duration of circulatory arrest, but not antegrade cerebral perfusion, prolongs postoperative recovery after neonatal cardiac surgery.
Topics: Aorta, Thoracic; Area Under Curve; Biomarkers; Cardiac Surgical Procedures; Cardiopulmonary Bypass; | 2012 |
Lactate levels predict mortality and need for peritoneal dialysis in children undergoing congenital heart surgery.
Topics: Acute Kidney Injury; Child, Preschool; Female; Heart Defects, Congenital; Humans; Infant; Intubation | 2012 |
Predictors for use of temporary epicardial pacing wires after pediatric cardiac surgery.
Topics: Academic Medical Centers; Arrhythmias, Cardiac; Biomarkers; California; Cardiac Catheterization; Car | 2012 |
Resting energy expenditure after Fontan surgery in children with single-ventricle heart defects.
Topics: Basal Metabolism; Calorimetry, Indirect; Child, Preschool; Energy Metabolism; Female; Fontan Procedu | 2012 |
The combination of RACHS-1 and postoperative blood lactate levels is a better prognostic mean after pediatric cardiac surgery than each alone.
Topics: Algorithms; Cardiac Surgical Procedures; Child; Heart Defects, Congenital; Humans; Lactic Acid; Logi | 2012 |
Serum cortisol concentration with exploratory cut-off values do not predict the effects of hydrocortisone administration in children with low cardiac output after cardiac surgery.
Topics: Adrenal Insufficiency; Age Factors; Biomarkers; Blood Pressure; Cardiac Output, Low; Cardiac Surgica | 2012 |
B-type natriuretic peptide levels predict outcomes in infants undergoing cardiac surgery in a lesion-dependent fashion.
Topics: Biomarkers; Cardiac Surgical Procedures; Female; Heart Defects, Congenital; Heart Ventricles; Hemody | 2013 |
Clinical outcome score predicts the need for neurodevelopmental intervention after infant heart surgery.
Topics: Biomarkers; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cardiotonic Agents; Chi-Square Dist | 2013 |
The impact of intraoperative vasopressin infusion in complex neonatal cardiac surgery.
Topics: Alanine Transaminase; Aspartate Aminotransferases; Biomarkers; Blood Urea Nitrogen; Cardiac Surgical | 2012 |
Intraoperative plasma lactate as an early indicator of major postoperative events in pediatric cardiac patients.
Topics: Biomarkers; Blood Gas Analysis; Cardiopulmonary Bypass; Heart Defects, Congenital; Humans; Intraoper | 2012 |
Blood lactate concentration in relation to absolute and relative work load in normal men, and in mitral stenosis, atrial septal defect and vasoregulatory asthenia.
Topics: Asthenia; Heart Defects, Congenital; Heart Septal Defects; Heart Septal Defects, Atrial; Heart Septu | 1959 |
[BEHAVIOR OF BLOOD LACTIC ACID IN CHILDREN WITH HEART DISEASE. II. CONGENITAL HEART DISEASE].
Topics: Aortic Coarctation; Blood Chemical Analysis; Child; Ductus Arteriosus; Ductus Arteriosus, Patent; He | 1963 |
BLOOD LACTATE, PYRUVATE AND LACTATE-PYRUVATE RATIOS IN CONGENITAL HEART DISEASE.
Topics: Blood Chemical Analysis; Child; Heart Defects, Congenital; Humans; Hypoxia; Lactates; Lactic Acid; N | 1964 |
THE ACID-BASE STATUS IN CYANOTIC CONGENITAL HEART DISEASE.
Topics: Acid-Base Equilibrium; Acidosis; Blood Gas Analysis; Cardiac Output; Heart Defects, Congenital; Huma | 1965 |
[Blood lactic acid in cyanogenic congenital heart defects of surgical interest (pre- and postoperative study)].
Topics: Heart Defects, Congenital; Humans; Lactates; Lactic Acid; Postoperative Period | 1961 |
The metabolism of lactate and pyruvate in children with congenital heart disease.
Topics: Child; Heart; Heart Defects, Congenital; Humans; Lactates; Lactic Acid; Pyruvates; Pyruvic Acid | 1950 |
[Evaluation of sternal deformity after pediatric minimally invasive cardiac surgery].
Topics: Absorbable Implants; Adolescent; Bone Nails; Bone Wires; Cardiac Surgical Procedures; Child; Child, | 2004 |
Efficacy of a criterion-driven transfusion protocol in patients having pediatric cardiac surgery.
Topics: Adolescent; Biomarkers; Body Temperature; Body Weight; Cardiac Surgical Procedures; Cardiopulmonary | 2004 |
Point of care testing: improving pediatric outcomes.
Topics: Blood Gas Analysis; Carbon Dioxide; Florida; Heart Defects, Congenital; Hospital Mortality; Hospital | 2004 |
Goal-directed medical therapy and point-of-care testing improve outcomes after congenital heart surgery.
Topics: Algorithms; Heart Defects, Congenital; Hospital Mortality; Hospitals, Pediatric; Humans; Infant; Inf | 2005 |
The strong ion gap predicts mortality in children following cardiopulmonary bypass surgery.
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Cardiopulmonary Bypass; Child, Preschool; Heart Defects, Co | 2005 |
Change in plasma volume during peak exercise in patients with cyanotic congenital heart disease after definitive operation.
Topics: Adolescent; Child; Cyanosis; Electrocardiography; Exercise; Exercise Test; Fontan Procedure; Heart D | 2006 |
Postoperative lactate concentrations predict the outcome of infants aged 6 weeks or less after intracardiac surgery: a cohort follow-up to 18 months.
Topics: Biomarkers; Blindness; Cardiac Surgical Procedures; Cerebral Palsy; Child Development; Cohort Studie | 2005 |
Is an increase in lactate concentration associated with cardiac dysfunction after the Fontan procedure?
Topics: Adolescent; Cardiac Output; Child; Child, Preschool; Fontan Procedure; Heart Defects, Congenital; He | 2005 |
Can the outcome of pediatric extracorporeal membrane oxygenation after cardiac surgery be predicted?
Topics: Cardiac Surgical Procedures; Cardiotonic Agents; Child; Child, Preschool; Disseminated Intravascular | 2006 |
Prognostic value of plasma N-terminal pro-brain natriuretic peptide in children with congenital heart defects and open-heart surgery.
Topics: Biomarkers; Cardiopulmonary Bypass; Cardiotonic Agents; Child; Child, Preschool; Heart Defects, Cong | 2006 |
Relevance of the measurement of the concentration of lactate in the serum subsequent to the Fontan procedure in small children.
Topics: Biomarkers; Follow-Up Studies; Fontan Procedure; Heart Defects, Congenital; Humans; Infant; Lactic A | 2006 |
Continuous hemodiafiltration during cardiopulmonary bypass in infants.
Topics: Acid-Base Imbalance; Calcium; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Heart Defects, Co | 2007 |
Myocardial substrates in children with congenital heart disease: relationship to substrate supply, age, growth and desaturation.
Topics: 3-Hydroxybutyric Acid; Adolescent; Age Factors; Analysis of Variance; Blood Chemical Analysis; Blood | 2007 |
Fetal stress response to fetal cardiac surgery.
Topics: Acid-Base Equilibrium; Animals; beta-Endorphin; Carbon Dioxide; Cardiopulmonary Bypass; Female; Feta | 2008 |
Fetal stress response to fetal cardiac surgery. Invited commentary.
Topics: Animals; beta-Endorphin; Cardiopulmonary Bypass; Female; Fetal Distress; Fetoscopy; Heart Defects, C | 2008 |
Positron emission tomography. The technique and its applications to the study of the cardiovascular system.
Topics: Acetates; Amino Acids; Blood Glucose; Cardiomyopathies; Child; Coronary Circulation; Energy Metaboli | 1983 |
Interpretation of blood lactate measurements in paediatric open-heart surgery and in extracorporeal membrane oxygenation.
Topics: Cardiac Surgical Procedures; Extracorporeal Membrane Oxygenation; Female; Heart Defects, Congenital; | 1995 |
Alterations in plasma phosphorus, red cell 2,3-diphosphoglycerate and P50 following open heart surgery.
Topics: 2,3-Diphosphoglycerate; Adenosine Triphosphate; Analysis of Variance; Blood Preservation; Blood Tran | 1994 |
Air travel and adults with cyanotic congenital heart disease.
Topics: 2,3-Diphosphoglycerate; Adolescent; Adult; Aerospace Medicine; Diphosphoglyceric Acids; Female; Hear | 1996 |
[Metabolic alkalosis after heart surgery interventions in childhood].
Topics: Alkalosis; Blood Component Transfusion; Blood Gas Analysis; Child; Child, Preschool; Female; Heart D | 1995 |
Initial postoperative serum lactate levels predict survival in children after open heart surgery.
Topics: Adolescent; Cardiac Surgical Procedures; Child; Child, Preschool; Heart Defects, Congenital; Humans; | 1996 |
Serum lactate as a predictor of mortality after paediatric cardiac surgery.
Topics: Biomarkers; Child, Preschool; Heart Defects, Congenital; Humans; Infant; Lactic Acid; Postoperative | 1997 |
Changes in whole blood lactate levels during cardiopulmonary bypass for surgery for congenital cardiac disease: an early indicator of morbidity and mortality.
Topics: Adolescent; Adult; Cardiopulmonary Bypass; Child; Child, Preschool; Female; Heart Defects, Congenita | 2000 |
Prenatal diagnosis of congenital heart disease affects preoperative acidosis in the newborn patient.
Topics: Acidosis; Cardiac Surgical Procedures; Female; Fetal Diseases; Gestational Age; Heart Defects, Conge | 2001 |
[Perioperative assessment of blood lactate levels in pediatric heart surgery].
Topics: Adolescent; Biomarkers; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Child; Child, Preschool | 2001 |
Lactacidosis in the neonate is minimized by prenatal detection of congenital heart disease.
Topics: Acidosis, Lactic; Female; Heart Defects, Congenital; Humans; Hydrogen-Ion Concentration; Infant, New | 2002 |
Chronic hypoxia: a model for cyanotic congenital heart defects.
Topics: Adenosine Triphosphate; Animals; Cardiopulmonary Bypass; Chronic Disease; Cyanosis; Disease Models, | 2002 |
Purines, lactate and phosphate release from child and adult heart during cardioplegic arrest.
Topics: Adult; Cardioplegic Solutions; Child; Child, Preschool; Coronary Disease; Heart Arrest, Induced; Hea | 1990 |