lactic acid has been researched along with Glycogen Storage Disease Type V in 40 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Glycogen Storage Disease Type V: Glycogenosis due to muscle phosphorylase deficiency. Characterized by painful cramps following sustained exercise.
| Excerpt | Relevance | Reference |
|---|---|---|
| "During constant work-rate exercise above the lactic acidosis threshold, oxygen consumption fails to plateau by 3 minutes, but continues to rise slowly." | 3.72 | Gas exchange responses to constant work-rate exercise in patients with glycogenosis type V and VII. ( Lovell, S; Nicholls, DP; O'Dochartaigh, CS; Ong, HY; Patterson, VH; Riley, MS; Wasserman, K, 2004) |
| " Needle muscle biopsy specimens for biochemical measurement were obtained before and immediately after maximal short-term bicycle exercise test from 12 patients suffering from autosomal dominant and recessive forms of progressive external ophthalmoplegia and multiple deletions of mitochondrial DNA (adPEO, arPEO, respectively), five patients with mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) 3243 A-->G point mutation, and four patients with McArdle's disease." | 3.71 | ATP, phosphocreatine and lactate in exercising muscle in mitochondrial disease and McArdle's disease. ( Härkönen, M; Lindholm, H; Löfberg, M; Majander, A; Näveri, H; Paetau, A; Somer, H; Sovijärvi, A; Suomalainen, A, 2001) |
| "Nine participants with McArdle disease were included in the study." | 3.30 | Repeated oral sucrose dosing after the second wind is unnecessary in patients with McArdle disease: Results from a randomized, placebo-controlled, double-blind, cross-over study. ( Khawajazada, T; Løkken, N; Slipsager, A; Vissing, J; Voermans, NC, 2023) |
| "Participants were four patients with McArdle disease and seven healthy subjects." | 2.80 | Lactate and Energy Metabolism During Exercise in Patients With Blocked Glycogenolysis (McArdle Disease). ( Haller, RG; Hauerslev, S; Heinicke, K; Jeppesen, TD; Preisler, N; Taivassalo, T; van Hall, G; Vissing, J; Ørngreen, MC, 2015) |
| "Patients with muscle phosphofructokinase deficiency are unable to achieve a spontaneous second wind under conditions that consistently produce one in patients with McArdle's disease." | 2.71 | No spontaneous second wind in muscle phosphofructokinase deficiency. ( Haller, RG; Vissing, J, 2004) |
| "Nine patients with McArdle disease, one with the partial glycolytic defect phosphoglycerate mutase deficiency, and nine matched, healthy subjects performed the classic ischemic forearm protocol and an identical protocol without ischemia." | 2.70 | A nonischemic forearm exercise test for McArdle disease. ( Haller, RG; Jensen, TD; Kazemi-Esfarjani, P; Skomorowska, E; Vissing, J, 2002) |
| "Blocked glycogen breakdown in McArdle disease impairs oxidative as well as anaerobic metabolism, but the contribution of impaired oxidative phosphorylation to everyday symptoms of McArdle disease remains poorly defined." | 2.70 | Spontaneous "second wind" and glucose-induced second "second wind" in McArdle disease: oxidative mechanisms. ( Haller, RG; Vissing, J, 2002) |
| "McArdle disease is an autosomal recessive condition caused by deficiency of the PYGM gene-encoded muscle isoform of glycogen phosphorylase." | 1.48 | Manifesting heterozygotes in McArdle disease: a myth or a reality-role of statins. ( Almendrote, M; Ara, I; Arenas, J; Ballester-Lopez, A; Coenen, D; Coll-Cantí, J; de Castro, M; Koehorst, E; Linares-Pardo, I; Lucente, G; Lucia, A; Martín, MA; Martínez-Piñeiro, A; Nogales-Gadea, G; Núñez-Manchón, J; Pintos-Morell, G; Ramos-Fransi, A; Rodriguez-Lopez, C; Santalla, A; Santos-Lozano, A, 2018) |
| "McArdle disease is due to an absence of the enzyme muscle glycogen phosphorylase and results in significant physical impairment in humans." | 1.42 | Investigating sodium valproate as a treatment for McArdle disease in sheep. ( Creed, KE; Dunton, E; Howell, JM; Quinlivan, R; Sewry, C, 2015) |
| "The two patients with atypical McArdle disease carried common mutations on one allele (R50X and G205S), and novel splice mutations in introns 3 [IVS3-26A>G (c." | 1.35 | Splice mutations preserve myophosphorylase activity that ameliorates the phenotype in McArdle disease. ( Duno, M; Haller, RG; Schwartz, M; Vissing, J, 2009) |
| "Patients with McArdle disease are unable to produce lactate in response to exercise and thus offer a unique model to assess the role of lactate in the EIGR." | 1.35 | The role of lactate in the exercise-induced human growth hormone response: evidence from McArdle disease. ( Buckley, J; Godfrey, RJ; Quinlivan, R; Whyte, GP, 2009) |
| "A 9-year-old boy with McArdle disease, who demonstrated remarkable recovery of objectively measured exercise tolerance after 1 year of follow-up, during which he pursued age-appropriate physical activities." | 1.35 | One-year follow-up in a child with McArdle disease: exercise is medicine. ( Arenas, J; Foster, C; González-Freire, M; Lucia, A; Pérez, M, 2008) |
| "Myasthenia gravis was diagnosed at 24 years of age." | 1.34 | Double trouble (McArdle's disease and myasthenia gravis): how can exercise help? ( Arenas, J; Foster, C; Gutiérrez-Rivas, E; Lucia, A; Maté-Muñoz, JL; Pérez, M, 2007) |
| "1." | 1.31 | The exercise metaboreflex is maintained in the absence of muscle acidosis: insights from muscle microdialysis in humans with McArdle's disease. ( Haller, RG; MacLean, DA; Saltin, B; Sander, M; Vissing, J; Vissing, SF, 2001) |
| "Patients with McArdle's disease cycled for 11-13 min at submaximal (40 W) rates, and to fatigue at maximal work rates of 60-90 W." | 1.29 | Tricarboxylic acid cycle intermediates during incremental exercise in healthy subjects and in patients with McArdle's disease. ( Haller, RG; Henriksson, KG; Jorfeldt, L; Lewis, SF; Sahlin, K, 1995) |
| "A 64-year-old female with McArdle's disease and non-insulin-dependent diabetes mellitus (NIDDM) is reported." | 1.29 | McArdle's disease with non-insulin-dependent diabetes mellitus: the beneficial effects of hyperglycemia and hyperinsulinemia for exercise intolerance. ( Amano, K; Ichikawa, Y; Kono, N; Maruyama, H; Nakamoto, S; Saruta, T; Takei, I; Yamauchi, A, 1996) |
| "Five patients with McArdle's disease and five patients with mitochondrial myopathies performed the same incremental maximal exercise test." | 1.28 | Exercise intolerance in patients with McArdle's disease or mitochondrial myopathies. ( Camus, F; Chaussain, M; Defoligny, C; Eymard, B; Fardeau, M, 1992) |
| "McArdle disease is reported in three generations of a consanguineous Druze family." | 1.28 | McArdle disease in a Druze family. ( Sadeh, M; Sarova-Pinhas, I, 1989) |
| "Three patients with McArdle's disease exercised for 2 h at 30% VO2max." | 1.27 | The second wind phenomenon in McArdle's disease. ( Binkhorst, RA; Braakhekke, JP; de Bruin, MI; Joosten, EM; Stegeman, DF; Wevers, RA, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (20.00) | 18.7374 |
| 1990's | 9 (22.50) | 18.2507 |
| 2000's | 18 (45.00) | 29.6817 |
| 2010's | 4 (10.00) | 24.3611 |
| 2020's | 1 (2.50) | 2.80 |
| Authors | Studies |
|---|---|
| Løkken, N | 1 |
| Khawajazada, T | 1 |
| Slipsager, A | 1 |
| Voermans, NC | 1 |
| Vissing, J | 13 |
| Núñez-Manchón, J | 1 |
| Ballester-Lopez, A | 1 |
| Koehorst, E | 1 |
| Linares-Pardo, I | 1 |
| Coenen, D | 1 |
| Ara, I | 1 |
| Rodriguez-Lopez, C | 1 |
| Ramos-Fransi, A | 1 |
| Martínez-Piñeiro, A | 1 |
| Lucente, G | 1 |
| Almendrote, M | 1 |
| Coll-Cantí, J | 1 |
| Pintos-Morell, G | 1 |
| Santos-Lozano, A | 1 |
| Arenas, J | 3 |
| Martín, MA | 1 |
| de Castro, M | 1 |
| Lucia, A | 3 |
| Santalla, A | 1 |
| Nogales-Gadea, G | 1 |
| Howell, JM | 1 |
| Dunton, E | 1 |
| Creed, KE | 1 |
| Quinlivan, R | 2 |
| Sewry, C | 1 |
| Ørngreen, MC | 2 |
| Jeppesen, TD | 2 |
| Taivassalo, T | 1 |
| Hauerslev, S | 1 |
| Preisler, N | 1 |
| Heinicke, K | 1 |
| Haller, RG | 10 |
| van Hall, G | 1 |
| Joshi, PR | 1 |
| Apitz, T | 1 |
| Zierz, S | 1 |
| Duno, M | 1 |
| Schwartz, M | 1 |
| Kazemi-Esfarjani, P | 2 |
| Skomorowska, E | 2 |
| Jensen, TD | 2 |
| Lindner, A | 1 |
| Lindholm, H | 2 |
| Löfberg, M | 2 |
| Somer, H | 2 |
| Näveri, H | 2 |
| Sovijärvi, A | 2 |
| Ong, HY | 1 |
| O'Dochartaigh, CS | 1 |
| Lovell, S | 1 |
| Patterson, VH | 2 |
| Wasserman, K | 1 |
| Nicholls, DP | 2 |
| Riley, MS | 1 |
| Livingstone, C | 1 |
| Al Riyami, S | 1 |
| Wilkins, P | 1 |
| Ferns, GA | 1 |
| Maté-Muñoz, JL | 1 |
| Pérez, M | 2 |
| Foster, C | 2 |
| Gutiérrez-Rivas, E | 1 |
| Godfrey, RJ | 1 |
| Whyte, GP | 1 |
| Buckley, J | 1 |
| González-Freire, M | 1 |
| Schelhaas, HJ | 1 |
| Akman, HO | 1 |
| Wevers, RA | 2 |
| Andersen, ST | 1 |
| ter Laak, HJ | 1 |
| van Diggelen, OP | 1 |
| DiMauro, S | 1 |
| Mineo, I | 2 |
| Kono, N | 3 |
| Shimizu, T | 2 |
| Sumi, S | 2 |
| Nonaka, K | 2 |
| Tarui, S | 2 |
| Rumpf, KW | 1 |
| Wagner, H | 1 |
| Kaiser, H | 1 |
| Meinck, HM | 1 |
| Goebel, HH | 1 |
| Scheler, F | 1 |
| Hagberg, JM | 2 |
| Coyle, EF | 1 |
| Carroll, JE | 1 |
| Miller, JM | 1 |
| Martin, WH | 1 |
| Brooke, MH | 1 |
| Sahlin, K | 1 |
| Jorfeldt, L | 1 |
| Henriksson, KG | 1 |
| Lewis, SF | 2 |
| Yamauchi, A | 1 |
| Amano, K | 1 |
| Ichikawa, Y | 1 |
| Nakamoto, S | 1 |
| Takei, I | 1 |
| Maruyama, H | 1 |
| Saruta, T | 1 |
| Campbell, NP | 1 |
| Stevenson, HP | 1 |
| Vissing, SF | 2 |
| MacLean, DA | 2 |
| Saltin, B | 2 |
| Quistorff, B | 1 |
| Vanuxem, D | 1 |
| Delpierre, S | 1 |
| Fauvelle, E | 1 |
| Guillot, C | 1 |
| Vanuxem, P | 1 |
| Zaman, Z | 1 |
| De Raedt, S | 1 |
| Majander, A | 1 |
| Suomalainen, A | 1 |
| Paetau, A | 1 |
| Härkönen, M | 1 |
| Sander, M | 1 |
| Nielsen, JN | 1 |
| Wojtaszewski, JF | 1 |
| Hardie, DG | 1 |
| Kemp, BE | 1 |
| Richter, EA | 1 |
| Chaussain, M | 1 |
| Camus, F | 1 |
| Defoligny, C | 1 |
| Eymard, B | 1 |
| Fardeau, M | 1 |
| Galbo, H | 1 |
| Wagner, DR | 1 |
| Zöllner, N | 1 |
| King, DS | 1 |
| Rogers, MA | 1 |
| Montain, SJ | 1 |
| Jilka, SM | 1 |
| Kohrt, WM | 1 |
| Heller, SL | 1 |
| Sarova-Pinhas, I | 1 |
| Sadeh, M | 1 |
| Braakhekke, JP | 1 |
| de Bruin, MI | 1 |
| Stegeman, DF | 1 |
| Binkhorst, RA | 1 |
| Joosten, EM | 1 |
| van Riet, W | 1 |
| de Meirsman, J | 1 |
| de Saedeleer, J | 1 |
| Dom, R | 1 |
| Carton, H | 1 |
| van den Heede, J | 1 |
| Bulcke, JA | 1 |
| Hara, N | 1 |
| Yamada, Y | 1 |
| Williams, J | 1 |
| Hosking, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase II Pilot Study to Explore Treatment With Sodium Valproate in Adults With McArdle Disease (Glycogen Storage Disorder Type V, GSDV)[NCT03112889] | Phase 2 | 8 participants (Anticipated) | Interventional | 2015-01-31 | Completed | ||
| Energy Supplements to Improve Exercise Tolerance in Metabolic Myopathies[NCT02448667] | 15 participants (Anticipated) | Interventional | 2015-01-31 | Recruiting | |||
| Triheptanoin's Effect on Fatty Acid Oxidation and Exercise Tolerance in Patients With Debrancher Deficiency, Glycogenin-1 Deficiency and Phosphofructoinase Deficiency at Rest and During Exercise. A Randomized, Double-blind, Placebo-controlled, Cross-over [NCT03642860] | Phase 2 | 3 participants (Actual) | Interventional | 2018-08-15 | Terminated (stopped due to Problems with recruitment) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 trials available for lactic acid and Glycogen Storage Disease Type V
| Article | Year |
|---|---|
Repeated oral sucrose dosing after the second wind is unnecessary in patients with McArdle disease: Results from a randomized, placebo-controlled, double-blind, cross-over study.
Topics: Blood Glucose; Cross-Over Studies; Double-Blind Method; Fatty Acids; Glucose; Glycogen Storage Disea | 2023 |
Lactate and Energy Metabolism During Exercise in Patients With Blocked Glycogenolysis (McArdle Disease).
Topics: Adult; Energy Metabolism; Exercise; Exercise Test; Female; Glycogen Storage Disease Type V; Glycogen | 2015 |
A nonischemic forearm exercise test for McArdle disease.
Topics: Adult; Ammonia; Exercise; Exercise Test; Female; Forearm; Glycogen Storage Disease Type V; Hand Stre | 2002 |
Spontaneous "second wind" and glucose-induced second "second wind" in McArdle disease: oxidative mechanisms.
Topics: Adult; Anaerobic Threshold; Cardiac Output; Exercise; Female; Glucose; Glycogen Phosphorylase, Muscl | 2002 |
No spontaneous second wind in muscle phosphofructokinase deficiency.
Topics: Adolescent; Adult; Ammonia; Child; Exercise Test; Fasting; Female; Glycogen Storage Disease Type V; | 2004 |
35 other studies available for lactic acid and Glycogen Storage Disease Type V
| Article | Year |
|---|---|
Manifesting heterozygotes in McArdle disease: a myth or a reality-role of statins.
Topics: Adult; Aged; Aged, 80 and over; Exercise Test; Family; Female; Genetic Testing; Glycogen Phosphoryla | 2018 |
Investigating sodium valproate as a treatment for McArdle disease in sheep.
Topics: Animals; Aspartate Aminotransferases; Calcium; Creatine Kinase; Disease Models, Animal; Drug Adminis | 2015 |
Normal activities of AMP-deaminase and adenylate kinase in patients with McArdle disease.
Topics: Adenylate Kinase; Adolescent; Adult; AMP Deaminase; Female; Forearm; Glycogen Storage Disease Type V | 2016 |
Splice mutations preserve myophosphorylase activity that ameliorates the phenotype in McArdle disease.
Topics: Adult; Cardiac Output; Exercise Test; Female; Forearm; Glycogen Phosphorylase, Muscle Form; Glycogen | 2009 |
[The lactate-ischemia test: efficient for diagnosis of myopathy?].
Topics: Adult; Ammonia; Diagnosis, Differential; Female; Glycogen Storage Disease Type V; Humans; Ischemia; | 2002 |
Abnormal blood lactate accumulation after exercise in patients with multiple mitochondrial DNA deletions and minor muscular symptoms.
Topics: Adult; Case-Control Studies; DNA, Mitochondrial; Exercise; Female; Gene Deletion; Glycogen Storage D | 2004 |
Gas exchange responses to constant work-rate exercise in patients with glycogenosis type V and VII.
Topics: Acidosis, Lactic; Adult; Case-Control Studies; Epinephrine; Exercise; Exercise Test; Exercise Tolera | 2004 |
McArdle's disease diagnosed following statin-induced myositis.
Topics: Aged; Ammonia; Anticholesteremic Agents; Creatine Kinase; Glycogen Storage Disease Type V; Humans; L | 2004 |
Lactic acid accumulation is an advantage/disadvantage during muscle activity.
Topics: Animals; Energy Metabolism; Glycogen; Glycogen Storage Disease Type V; Humans; Lactates; Lactic Acid | 2006 |
Double trouble (McArdle's disease and myasthenia gravis): how can exercise help?
Topics: Adult; Cell Enlargement; Creatine Kinase; Energy Metabolism; Exercise; Exercise Therapy; Exercise To | 2007 |
The role of lactate in the exercise-induced human growth hormone response: evidence from McArdle disease.
Topics: Adolescent; Adult; Exercise; Exercise Test; Female; Glycogen Storage Disease Type V; Human Growth Ho | 2009 |
One-year follow-up in a child with McArdle disease: exercise is medicine.
Topics: Blood Glucose; Child; Creatine Kinase; Exercise; Exercise Therapy; Exercise Tolerance; Follow-Up Stu | 2008 |
Is muscle glycogenolysis impaired in X-linked phosphorylase b kinase deficiency?
Topics: Chromosomes, Human, X; Exercise Test; Glycogen; Glycogen Storage Disease Type V; Glycogen Storage Di | 2008 |
A comparative study on glucagon effect between McArdle disease and Tarui disease.
Topics: Adult; Female; Glucagon; Glucose; Glycogen Storage Disease; Glycogen Storage Disease Type V; Humans; | 1984 |
Increased ammonia production during forearm ischemic work test in McArdle's disease.
Topics: Ammonia; Forearm; Glycogen; Glycogen Storage Disease; Glycogen Storage Disease Type V; Humans; Ische | 1981 |
Exercise hyperventilation in patients with McArdle's disease.
Topics: Adult; Female; Glycogen Storage Disease; Glycogen Storage Disease Type V; Humans; Hyperventilation; | 1982 |
Tricarboxylic acid cycle intermediates during incremental exercise in healthy subjects and in patients with McArdle's disease.
Topics: Adult; Alanine; Citrates; Citric Acid Cycle; Exercise; Female; Fumarates; Glutamic Acid; Glycogen St | 1995 |
McArdle's disease with non-insulin-dependent diabetes mellitus: the beneficial effects of hyperglycemia and hyperinsulinemia for exercise intolerance.
Topics: Biopsy; Blood Glucose; Cerebral Infarction; Creatine Kinase; Diabetes Mellitus, Type 2; Eating; Exer | 1996 |
Angina in McArdle's disease.
Topics: Aged; Angina Pectoris; Cardiac Pacing, Artificial; Electrophoresis, Polyacrylamide Gel; Gene Express | 1996 |
Sympathetic activation in exercise is not dependent on muscle acidosis. Direct evidence from studies in metabolic myopathies.
Topics: Acidosis; Adult; Case-Control Studies; Exercise; Female; Glycogen Storage Disease Type V; Humans; Hy | 1998 |
Blood ammonia and ventilation at maximal exercise.
Topics: Adult; Ammonia; Exercise; Female; Glycogen Storage Disease Type V; Glycolysis; Humans; Lactic Acid; | 1998 |
Ischemic exercise testing in suspected McArdle disease.
Topics: Blood Pressure; Blood Specimen Collection; Exercise Test; Forearm; Glycogen Storage Disease Type V; | 2000 |
ATP, phosphocreatine and lactate in exercising muscle in mitochondrial disease and McArdle's disease.
Topics: Adenosine Triphosphate; Adult; Aged; DNA, Mitochondrial; Electron Transport; Enzymes; Exercise; Exer | 2001 |
The exercise metaboreflex is maintained in the absence of muscle acidosis: insights from muscle microdialysis in humans with McArdle's disease.
Topics: Acidosis; Adult; Ammonia; Arm; Cardiovascular System; Exercise; Female; Glycogen Storage Disease Typ | 2001 |
A forearm exercise screening test for mitochondrial myopathy.
Topics: Adult; Aged; Analysis of Variance; Exercise Test; Female; Forearm; Glycogen Storage Disease Type V; | 2002 |
Role of 5'AMP-activated protein kinase in glycogen synthase activity and glucose utilization: insights from patients with McArdle's disease.
Topics: Acetyl-CoA Carboxylase; Adult; AMP-Activated Protein Kinases; Blood Glucose; Exercise; Female; Gluco | 2002 |
Exercise intolerance in patients with McArdle's disease or mitochondrial myopathies.
Topics: Adult; Alanine; Ammonia; Energy Metabolism; Exercise Test; Exercise Tolerance; Female; Glycogen Stor | 1992 |
Effect of deficient muscular glycogenolysis on extramuscular fuel production in exercise.
Topics: Adult; Energy Metabolism; Exercise; Glycogen; Glycogen Storage Disease Type V; Hemodynamics; Hormone | 1992 |
McArdle's disease: successful symptomatic therapy by high dose oral administration of ribose.
Topics: Administration, Oral; Adult; Ammonia; Dose-Response Relationship, Drug; Glycogen Storage Disease Typ | 1991 |
Exercise and recovery ventilatory and VO2 responses of patients with McArdle's disease.
Topics: Adult; Aged; Blood; Exercise; Female; Glycogen Storage Disease Type V; Heart Rate; Humans; Hydrogen- | 1990 |
McArdle disease in a Druze family.
Topics: Adult; Aged; Biopsy; Child, Preschool; Consanguinity; Exercise; Female; Glycogen; Glycogen Storage D | 1989 |
The second wind phenomenon in McArdle's disease.
Topics: Adaptation, Physiological; Adult; Ammonia; Blood Glucose; Cardiac Output; Electromyography; Fatigue; | 1986 |
Early onset myophosphorylase deficiency (Mc Ardle's disease) with absence of myophosphorylase protein on SDS electrophoresis. The role of the ischemic forearm test.
Topics: Adult; Biopsy; Electromyography; Electrophoresis, Polyacrylamide Gel; Exercise Test; Female; Forearm | 1985 |
Excess purine degradation in exercising muscles of patients with glycogen storage disease types V and VII.
Topics: Adult; Ammonia; Female; Glycogen Storage Disease; Glycogen Storage Disease Type V; Glycogen Storage | 1985 |
Type V glycogen storage disease.
Topics: Child; Creatine Kinase; Female; Glycogen Storage Disease; Glycogen Storage Disease Type V; Humans; L | 1985 |