lactic acid has been researched along with Glioblastoma in 111 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Glioblastoma: A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
| Excerpt | Relevance | Reference |
|---|---|---|
| "It has been suggested that local administration of topotecan (TT) could increase its efficacy in the treatment of glioblastoma." | 8.02 | Controlling the release rate of topotecan from PLGA spheres and increasing its cytotoxicity towards glioblastoma cells by co-loading with calcium chloride. ( Rubinstein, A; Sharon Gabbay, R, 2021) |
| "Recent experimental data showed that the PI3K pathway contributes to resistance to temozolomide (TMZ) in paediatric glioblastoma and that this effect is reversed by combination treatment of TMZ with a PI3K inhibitor." | 7.85 | In vitro nuclear magnetic resonance spectroscopy metabolic biomarkers for the combination of temozolomide with PI3K inhibition in paediatric glioblastoma cells. ( Agliano, A; Al-Saffar, NMS; Balarajah, G; Clarke, PA; Jackson, LE; Jones, C; Leach, MO; Marshall, LV; Pearson, ADJ; Sidhu, J; Workman, P, 2017) |
| "Glioblastoma remains an aggressive brain malignancy with poor prognosis despite advances in multimodal therapy that include standard use of Temozolomide." | 7.83 | Tailored Nanoparticle Codelivery of antimiR-21 and antimiR-10b Augments Glioblastoma Cell Kill by Temozolomide: Toward a "Personalized" Anti-microRNA Therapy. ( Ananta, JS; Massoud, TF; Paulmurugan, R, 2016) |
| "Lactoferrin (Lf) and folic acid (FA) were crosslinked on poly(lactide-co-glycolide) (PLGA) nanoparticles (NPs) for transporting etoposide across the blood-brain barrier (BBB) and treating human brain malignant glioblastoma." | 7.81 | Targeting delivery of etoposide to inhibit the growth of human glioblastoma multiforme using lactoferrin- and folic acid-grafted poly(lactide-co-glycolide) nanoparticles. ( Chen, YC; Kuo, YC, 2015) |
| "We currently use Convection-Enhanced Delivery (CED) of the platinum-based drug, carboplatin as a novel treatment strategy for high grade glioblastoma in adults and children." | 7.81 | Convection-Enhanced Delivery of Carboplatin PLGA Nanoparticles for the Treatment of Glioblastoma. ( Arshad, A; Barua, NU; Bienemann, AS; Edler, KJ; Gill, SS; Johnson, DE; Woolley, M; Wyatt, MJ; Yang, B, 2015) |
| "In this study, we developed and characterized a delivery system for the epigenetic demethylating drug, decitabine, to sensitize temozolomide-resistant human glioblastoma multiforme (GBM) cells to alkylating chemotherapy." | 7.81 | Decitabine nanoconjugate sensitizes human glioblastoma cells to temozolomide. ( Cui, Y; Irudayaraj, J; Naz, A; Thompson, DH, 2015) |
| " Celecoxib (CXB), a selective COX-2 inhibitor, is able to control inflammation and pain, to improve the efficacy of radiotherapy, and to inhibit at high doses the growth of cancer cells." | 7.80 | New celecoxib multiparticulate systems to improve glioblastoma treatment. ( Barcia, E; Fernández-Carballido, A; García-García, L; Marcianes, P; Negro, S; Slowing, K; Vera, M, 2014) |
| "Silver nanoparticles were entrapped inside the functionalized nanoparticles (Ag-PNP-CTX), to allow detection and quantification of the cellular uptake by confocal microscopy, both in vitro and in vivo." | 5.43 | A Combined Approach Employing Chlorotoxin-Nanovectors and Low Dose Radiation To Reach Infiltrating Tumor Niches in Glioblastoma. ( Corradini, I; Franchini, MC; Locatelli, E; Matteoli, M; Monaco, I; Passoni, L; Rasile, M; Rodighiero, S; Tamborini, M, 2016) |
| "Salinomycin has been introduced as a novel alternative to traditional anti-cancer drugs." | 5.43 | Salinomycin encapsulated nanoparticles as a targeting vehicle for glioblastoma cells. ( Gümüşderelioğlu, M; Kaynak, G; Tığlı Aydın, RS, 2016) |
| " A preclinical technique called deuterium metabolic imaging has successfully imaged the Warburg Effect in vivo in glioblastoma." | 5.01 | New metabolic imaging tools in neuro-oncology. ( Corbin, ZA, 2019) |
| "Lactic acidosis has been reported in solid tumor microenvironment (TME) including glioblastoma (GBM)." | 4.31 | Lactate modulates microglia polarization via IGFBP6 expression and remodels tumor microenvironment in glioblastoma. ( Altieri, R; Barbagallo, GMV; Broggi, G; Busi, F; Caltabiano, R; Caruso, M; Di Rosa, M; Forte, S; Giallongo, C; Li Volti, G; Liso, A; Lolicato, M; Longhitano, L; Mione, MC; Parenti, R; Raciti, G; Tibullo, D; Vicario, N, 2023) |
| "Our results indicate that TERT expression is associated with elevated NADH in multiple cancers, including glioblastoma, oligodendroglioma, melanoma, neuroblastoma, and hepatocellular carcinoma." | 4.12 | Deuterium Metabolic Imaging Reports on TERT Expression and Early Response to Therapy in Cancer. ( Barger, C; Batsios, G; Costello, JF; Gillespie, AM; Ronen, SM; Stevers, N; Taglang, C; Tran, M; Viswanath, P, 2022) |
| "It has been suggested that local administration of topotecan (TT) could increase its efficacy in the treatment of glioblastoma." | 4.02 | Controlling the release rate of topotecan from PLGA spheres and increasing its cytotoxicity towards glioblastoma cells by co-loading with calcium chloride. ( Rubinstein, A; Sharon Gabbay, R, 2021) |
| "Recent experimental data showed that the PI3K pathway contributes to resistance to temozolomide (TMZ) in paediatric glioblastoma and that this effect is reversed by combination treatment of TMZ with a PI3K inhibitor." | 3.85 | In vitro nuclear magnetic resonance spectroscopy metabolic biomarkers for the combination of temozolomide with PI3K inhibition in paediatric glioblastoma cells. ( Agliano, A; Al-Saffar, NMS; Balarajah, G; Clarke, PA; Jackson, LE; Jones, C; Leach, MO; Marshall, LV; Pearson, ADJ; Sidhu, J; Workman, P, 2017) |
| "Glioblastoma remains an aggressive brain malignancy with poor prognosis despite advances in multimodal therapy that include standard use of Temozolomide." | 3.83 | Tailored Nanoparticle Codelivery of antimiR-21 and antimiR-10b Augments Glioblastoma Cell Kill by Temozolomide: Toward a "Personalized" Anti-microRNA Therapy. ( Ananta, JS; Massoud, TF; Paulmurugan, R, 2016) |
| "We currently use Convection-Enhanced Delivery (CED) of the platinum-based drug, carboplatin as a novel treatment strategy for high grade glioblastoma in adults and children." | 3.81 | Convection-Enhanced Delivery of Carboplatin PLGA Nanoparticles for the Treatment of Glioblastoma. ( Arshad, A; Barua, NU; Bienemann, AS; Edler, KJ; Gill, SS; Johnson, DE; Woolley, M; Wyatt, MJ; Yang, B, 2015) |
| "Lactoferrin (Lf) and folic acid (FA) were crosslinked on poly(lactide-co-glycolide) (PLGA) nanoparticles (NPs) for transporting etoposide across the blood-brain barrier (BBB) and treating human brain malignant glioblastoma." | 3.81 | Targeting delivery of etoposide to inhibit the growth of human glioblastoma multiforme using lactoferrin- and folic acid-grafted poly(lactide-co-glycolide) nanoparticles. ( Chen, YC; Kuo, YC, 2015) |
| "In this study, we developed and characterized a delivery system for the epigenetic demethylating drug, decitabine, to sensitize temozolomide-resistant human glioblastoma multiforme (GBM) cells to alkylating chemotherapy." | 3.81 | Decitabine nanoconjugate sensitizes human glioblastoma cells to temozolomide. ( Cui, Y; Irudayaraj, J; Naz, A; Thompson, DH, 2015) |
| "Fenofibrate, a well-known normolipidemic drug, has been shown to exert strong anticancer effects against tumors of neuroectodermal origin including glioblastoma." | 3.81 | Fenofibrate subcellular distribution as a rationale for the intracranial delivery through biodegradable carrier. ( Ayyala, R; Blake, DA; Culicchia, F; Grabacka, M; John, VT; Ponnusamy, T; Reiss, K; Rutkowska, M; Vashistha, H; Waligorski, P; Wilk, A; Wisniewska-Becker, A; Wyczechowska, D; Zapata, A, 2015) |
| " Celecoxib (CXB), a selective COX-2 inhibitor, is able to control inflammation and pain, to improve the efficacy of radiotherapy, and to inhibit at high doses the growth of cancer cells." | 3.80 | New celecoxib multiparticulate systems to improve glioblastoma treatment. ( Barcia, E; Fernández-Carballido, A; García-García, L; Marcianes, P; Negro, S; Slowing, K; Vera, M, 2014) |
| "To demonstrate the feasibility of using DNP hyperpolarized [1-(13)C]-pyruvate to measure early response to temozolomide (TMZ) therapy using an orthotopic human glioblastoma xenograft model." | 3.77 | Detection of early response to temozolomide treatment in brain tumors using hyperpolarized 13C MR metabolic imaging. ( Bok, R; James, CD; Nelson, SJ; Ozawa, T; Park, I; Phillips, JJ; Ronen, SM; Vigneron, DB, 2011) |
| " In GS-2 glioblastoma cells, PI3K inhibition by LY294002 or everolimus caused hyperpolarized lactate to drop to 42 +/- 12% and to 76 +/- 5%, respectively." | 3.76 | Noninvasive detection of target modulation following phosphatidylinositol 3-kinase inhibition using hyperpolarized 13C magnetic resonance spectroscopy. ( Brandes, AH; Chaumeil, MM; Dafni, H; Haas-Kogan, DA; James, CD; Kurhanewicz, J; Nelson, SJ; Ronen, SM; Sukumar, S; Vancriekinge, M; Venkatesh, HS; Vigneron, DB; Ward, CS, 2010) |
| "For patients with nonresectable glioblastoma (GB) or recurrent GB, we have recently been using an interstitial chemotherapy with biodegradable polylactic acid pellets containing nimustine chloride (ACNU), in combination with superselective arterial ACNU injection, routine irradiation and chemotherapy." | 3.69 | Interstitial chemotherapy with biodegradable ACNU pellet for glioblastoma. ( Akai, F; Ioku, M; Iwasaki, H; Kaetsu, I; Kuroda, R; Nakatani, J; Uchiyama, T, 1994) |
| "The MS analyses from pancreatic cancer cells support a hypothesis that hypoxia promotes cells in solid tumor to reprogram metabolic pathways in order to minimize the oxygen consumption." | 2.52 | Cancer metabolism and mass spectrometry-based proteomics. ( Liotta, LA; Petricoin, EF; Zhou, W, 2015) |
| "Glioblastoma is a malignant brain tumor with poor prognosis." | 1.91 | Tumor-secreted lactate contributes to an immunosuppressive microenvironment and affects CD8 T-cell infiltration in glioblastoma. ( Cheng, Q; Dai, Z; Liang, X; Liu, Z; Luo, P; Wang, Z; Wen, Z; Zhang, H; Zhang, J; Zhang, M; Zhang, X, 2023) |
| "Glioblastoma is the most common and malignant brain tumor, and current therapies confer only modest survival benefits." | 1.51 | Nuclear Magnetic Resonance Spectroscopy to Identify Metabolite Biomarkers of Nonresponsiveness to Targeted Therapy in Glioblastoma Tumor Stem Cells. ( Berg, HE; Hvinden, IC; Lundanes, E; Rise, F; Sachse, D; Sandberg, CJ; Skaga, E; Skottvoll, FS; Vik-Mo, EO; Wilson, SR, 2019) |
| "We hypothesize that DCA exerts its anticancer effects via depriving cancer of acetate benefits." | 1.51 | Dichloroacetate is an antimetabolite that antagonizes acetate and deprives cancer cells from its benefits: A novel evidence-based medical hypothesis. ( Abdel-Aziz, W; Abdel-Latif, HM; Aboonq, MS; Ahmed, NS; Almaramhy, HH; Ayat, M; Baghdadi, H; El Sayed, SM; El-Sawy, SA; Elshazley, M; Ibrahim, W; Mahmoud, AA, 2019) |
| "Glioblastoma multiforme is the most lethal type of brain tumor and the established therapy only extends patients survival to approximately one year." | 1.48 | Receptor-mediated PLGA nanoparticles for glioblastoma multiforme treatment. ( Coelho, MAN; Gosselet, F; Lima, J; Loureiro, JA; Pereira, MC; Ramalho, MJ; Sevin, E, 2018) |
| "Salinomycin has been introduced as a novel alternative to traditional anti-cancer drugs." | 1.43 | Salinomycin encapsulated nanoparticles as a targeting vehicle for glioblastoma cells. ( Gümüşderelioğlu, M; Kaynak, G; Tığlı Aydın, RS, 2016) |
| "Silver nanoparticles were entrapped inside the functionalized nanoparticles (Ag-PNP-CTX), to allow detection and quantification of the cellular uptake by confocal microscopy, both in vitro and in vivo." | 1.43 | A Combined Approach Employing Chlorotoxin-Nanovectors and Low Dose Radiation To Reach Infiltrating Tumor Niches in Glioblastoma. ( Corradini, I; Franchini, MC; Locatelli, E; Matteoli, M; Monaco, I; Passoni, L; Rasile, M; Rodighiero, S; Tamborini, M, 2016) |
| "For the treatment of glioblastoma multiforme, an "anticancer drug cocktail" delivered by biodegradable poly-lactide-co-glycolide (PLGA)-microspheres is proposed." | 1.39 | A "drug cocktail" delivered by microspheres for the local treatment of rat glioblastoma. ( Allhenn, D; Béduneau, A; Lamprecht, A; Neumann, D; Pellequer, Y, 2013) |
| "The detection of a small number of circulating tumor cells (CTCs) is important, especially in the early stages of cancer." | 1.38 | Nanotextured substrates with immobilized aptamers for cancer cell isolation and cytology. ( Allen, PB; Bachoo, R; Ellington, AD; Iqbal, SM; Kim, YT; Li, N; Mahmood, MA; Wan, Y, 2012) |
| "In the renal cell carcinoma, in contrast with GBM, (13) C multiplets of γ-aminobutyric acid (GABA) differed from its precursor glutamate, suggesting that GABA did not derive from a common glutamate precursor pool." | 1.38 | Glucose metabolism via the pentose phosphate pathway, glycolysis and Krebs cycle in an orthotopic mouse model of human brain tumors. ( Bachoo, RM; Cho, SK; Choi, C; Deberardinis, RJ; Good, LB; Hatanpaa, KJ; Jindal, A; Kapur, P; Maher, EA; Malloy, CR; Marin-Valencia, I; Mashimo, T; Mickey, B; Pascual, JM; Raisanen, J; Rakheja, D; Sun, X; Takahashi, M; Togao, O; Vemireddy, V, 2012) |
| "For an efficient treatment of glioblastomas it is necessary to deliver anti-cancer drugs across the intact BBB." | 1.37 | Efficient chemotherapy of rat glioblastoma using doxorubicin-loaded PLGA nanoparticles with different stabilizers. ( Bernreuther, C; Gelperina, S; Glatzel, M; Khalansky, AS; Kreuter, J; Maksimenko, O; Wohlfart, S, 2011) |
| "The differential diagnosis between brain abscesses and necrotic tumors such as glioblastomas is sometimes difficult to establish by conventional computed tomography and magnetic resonance imaging." | 1.31 | Brain abscess and glioblastoma identified by combined proton magnetic resonance spectroscopy and diffusion-weighted magnetic resonance imaging--two case reports. ( Harada, M; Kageji, T; Nagahiro, S; Nakaiso, M; Takimoto, O; Uno, M, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (4.50) | 18.2507 |
| 2000's | 19 (17.12) | 29.6817 |
| 2010's | 63 (56.76) | 24.3611 |
| 2020's | 24 (21.62) | 2.80 |
| Authors | Studies |
|---|---|
| Su, X | 1 |
| Yang, Y | 1 |
| Yang, Q | 1 |
| Pang, B | 1 |
| Sun, S | 2 |
| Wang, Y | 2 |
| Qiao, Q | 1 |
| Guo, C | 1 |
| Liu, H | 3 |
| Pang, Q | 1 |
| Udawant, S | 1 |
| Litif, C | 1 |
| Lopez, A | 1 |
| Gunn, B | 1 |
| Schuenzel, E | 1 |
| Keniry, M | 1 |
| Wiwatchaitawee, K | 1 |
| Ebeid, K | 1 |
| Quarterman, JC | 1 |
| Naguib, Y | 1 |
| Ali, MY | 1 |
| Oliva, C | 1 |
| Griguer, C | 1 |
| Salem, AK | 1 |
| Harrison, MAA | 1 |
| Hochreiner, EM | 1 |
| Benjamin, BP | 1 |
| Lawler, SE | 1 |
| Zwezdaryk, KJ | 1 |
| Minami, N | 1 |
| Hong, D | 1 |
| Stevers, N | 2 |
| Barger, CJ | 1 |
| Radoul, M | 1 |
| Hong, C | 1 |
| Chen, L | 1 |
| Kim, Y | 1 |
| Batsios, G | 2 |
| Gillespie, AM | 2 |
| Pieper, RO | 1 |
| Costello, JF | 2 |
| Viswanath, P | 2 |
| Ronen, SM | 5 |
| Longhitano, L | 1 |
| Vicario, N | 1 |
| Forte, S | 1 |
| Giallongo, C | 1 |
| Broggi, G | 1 |
| Caltabiano, R | 1 |
| Barbagallo, GMV | 1 |
| Altieri, R | 1 |
| Raciti, G | 1 |
| Di Rosa, M | 1 |
| Caruso, M | 1 |
| Parenti, R | 1 |
| Liso, A | 1 |
| Busi, F | 1 |
| Lolicato, M | 1 |
| Mione, MC | 1 |
| Li Volti, G | 1 |
| Tibullo, D | 1 |
| Taglang, C | 1 |
| Tran, M | 1 |
| Barger, C | 1 |
| Ye, Z | 1 |
| Gao, L | 1 |
| Cai, J | 1 |
| Li, Y | 2 |
| Tong, S | 1 |
| Yan, T | 1 |
| Sun, Q | 1 |
| Qi, Y | 1 |
| Xu, Y | 1 |
| Jiang, H | 1 |
| Zhang, S | 2 |
| Zhao, L | 1 |
| Chen, Q | 1 |
| Zaccagna, F | 1 |
| McLean, MA | 2 |
| Grist, JT | 1 |
| Kaggie, J | 1 |
| Mair, R | 1 |
| Riemer, F | 1 |
| Woitek, R | 1 |
| Gill, AB | 1 |
| Deen, S | 1 |
| Daniels, CJ | 1 |
| Ursprung, S | 1 |
| Schulte, RF | 1 |
| Allinson, K | 1 |
| Chhabra, A | 1 |
| Laurent, MC | 1 |
| Locke, M | 1 |
| Frary, A | 1 |
| Hilborne, S | 1 |
| Patterson, I | 1 |
| Carmo, BD | 1 |
| Slough, R | 1 |
| Wilkinson, I | 1 |
| Basu, B | 1 |
| Wason, J | 1 |
| Gillard, JH | 1 |
| Matys, T | 1 |
| Watts, C | 1 |
| Price, SJ | 1 |
| Santarius, T | 1 |
| Graves, MJ | 1 |
| Jefferies, S | 1 |
| Brindle, KM | 1 |
| Gallagher, FA | 1 |
| Torrini, C | 1 |
| Nguyen, TTT | 2 |
| Shu, C | 1 |
| Mela, A | 1 |
| Humala, N | 1 |
| Mahajan, A | 1 |
| Seeley, EH | 1 |
| Zhang, G | 1 |
| Westhoff, MA | 2 |
| Karpel-Massler, G | 2 |
| Bruce, JN | 1 |
| Canoll, P | 1 |
| Siegelin, MD | 2 |
| Nakamura, Y | 2 |
| Inoue, A | 2 |
| Nishikawa, M | 2 |
| Ohnishi, T | 2 |
| Yano, H | 2 |
| Kanemura, Y | 2 |
| Ohtsuka, Y | 2 |
| Ozaki, S | 2 |
| Kusakabe, K | 1 |
| Suehiro, S | 2 |
| Yamashita, D | 2 |
| Shigekawa, S | 2 |
| Watanabe, H | 3 |
| Kitazawa, R | 2 |
| Tanaka, J | 2 |
| Kunieda, T | 2 |
| Shang, E | 1 |
| Guyon, J | 1 |
| Fernandez-Moncada, I | 1 |
| Larrieu, CM | 1 |
| Bouchez, CL | 1 |
| Pagano Zottola, AC | 1 |
| Galvis, J | 1 |
| Chouleur, T | 1 |
| Burban, A | 1 |
| Joseph, K | 1 |
| Ravi, VM | 1 |
| Espedal, H | 2 |
| Røsland, GV | 1 |
| Daher, B | 1 |
| Barre, A | 1 |
| Dartigues, B | 1 |
| Karkar, S | 1 |
| Rudewicz, J | 1 |
| Romero-Garmendia, I | 1 |
| Klink, B | 1 |
| Grützmann, K | 1 |
| Derieppe, MA | 1 |
| Molinié, T | 1 |
| Obad, N | 2 |
| Léon, C | 1 |
| Seano, G | 1 |
| Miletic, H | 2 |
| Heiland, DH | 1 |
| Marsicano, G | 1 |
| Nikolski, M | 1 |
| Bjerkvig, R | 2 |
| Bikfalvi, A | 2 |
| Daubon, T | 1 |
| Wang, Z | 2 |
| Dai, Z | 1 |
| Zhang, H | 2 |
| Liang, X | 1 |
| Zhang, X | 1 |
| Wen, Z | 1 |
| Luo, P | 1 |
| Zhang, J | 2 |
| Liu, Z | 1 |
| Zhang, M | 1 |
| Cheng, Q | 1 |
| Corbin, ZA | 1 |
| Rich, LJ | 1 |
| Bagga, P | 1 |
| Wilson, NE | 1 |
| Schnall, MD | 1 |
| Detre, JA | 1 |
| Haris, M | 1 |
| Reddy, R | 1 |
| Azzalin, A | 1 |
| Brambilla, F | 1 |
| Arbustini, E | 1 |
| Basello, K | 1 |
| Speciani, A | 1 |
| Mauri, P | 1 |
| Bezzi, P | 1 |
| Magrassi, L | 1 |
| Xue, W | 1 |
| Xu, K | 1 |
| Yi, L | 1 |
| Guo, Y | 1 |
| Xie, T | 1 |
| Tong, H | 1 |
| Zhou, B | 1 |
| Wang, S | 2 |
| Li, Q | 1 |
| Chen, X | 1 |
| Fang, J | 1 |
| Zhang, W | 1 |
| Bisdas, S | 1 |
| Schäfer, R | 1 |
| Kolb, R | 1 |
| Bender, B | 1 |
| Klose, U | 1 |
| Palma, A | 1 |
| Grande, S | 1 |
| Ricci-Vitiani, L | 1 |
| Luciani, AM | 1 |
| Buccarelli, M | 1 |
| Biffoni, M | 1 |
| Dini, V | 1 |
| Cirrone, GAP | 1 |
| Ciocca, M | 1 |
| Guidoni, L | 1 |
| Pallini, R | 1 |
| Viti, V | 1 |
| Rosi, A | 1 |
| Kubelt, C | 1 |
| Peters, S | 1 |
| Ahmeti, H | 1 |
| Huhndorf, M | 1 |
| Huber, L | 1 |
| Cohrs, G | 1 |
| Hövener, JB | 1 |
| Jansen, O | 1 |
| Synowitz, M | 1 |
| Held-Feindt, J | 1 |
| Mishkovsky, M | 1 |
| Gusyatiner, O | 1 |
| Lanz, B | 1 |
| Cudalbu, C | 1 |
| Vassallo, I | 1 |
| Hamou, MF | 1 |
| Bloch, J | 1 |
| Comment, A | 1 |
| Gruetter, R | 1 |
| Hegi, ME | 1 |
| Sharon Gabbay, R | 1 |
| Rubinstein, A | 1 |
| Kawai, T | 1 |
| Brender, JR | 1 |
| Lee, JA | 1 |
| Kramp, T | 1 |
| Kishimoto, S | 1 |
| Krishna, MC | 1 |
| Tofilon, P | 1 |
| Camphausen, KA | 1 |
| Matsumoto, S | 1 |
| Huang, WC | 1 |
| Lu, IL | 1 |
| Chiang, WH | 1 |
| Lin, YW | 1 |
| Tsai, YC | 1 |
| Chen, HH | 1 |
| Chang, CW | 1 |
| Chiang, CS | 1 |
| Chiu, HC | 1 |
| Malinovskaya, Y | 1 |
| Melnikov, P | 1 |
| Baklaushev, V | 1 |
| Gabashvili, A | 1 |
| Osipova, N | 1 |
| Mantrov, S | 1 |
| Ermolenko, Y | 1 |
| Maksimenko, O | 2 |
| Gorshkova, M | 1 |
| Balabanyan, V | 1 |
| Kreuter, J | 3 |
| Gelperina, S | 2 |
| Cata, JP | 1 |
| Bhavsar, S | 1 |
| Hagan, KB | 1 |
| Arunkumar, R | 1 |
| Grasu, R | 1 |
| Dang, A | 1 |
| Carlson, R | 1 |
| Arnold, B | 1 |
| Popat, K | 1 |
| Rao, G | 1 |
| Potylchansky, Y | 1 |
| Lipski, I | 1 |
| Ratty, S | 1 |
| Nguyen, AT | 1 |
| McHugh, T | 1 |
| Feng, L | 1 |
| Rahlfs, TF | 1 |
| Son, MJ | 1 |
| Ryu, JS | 1 |
| Kim, JY | 1 |
| Kwon, Y | 1 |
| Chung, KS | 1 |
| Mun, SJ | 1 |
| Cho, YS | 1 |
| Voss, DM | 1 |
| Spina, R | 1 |
| Carter, DL | 1 |
| Lim, KS | 2 |
| Jeffery, CJ | 1 |
| Bar, EE | 2 |
| Al-Saffar, NMS | 1 |
| Agliano, A | 2 |
| Marshall, LV | 2 |
| Jackson, LE | 2 |
| Balarajah, G | 2 |
| Sidhu, J | 1 |
| Clarke, PA | 3 |
| Jones, C | 2 |
| Workman, P | 2 |
| Pearson, ADJ | 1 |
| Leach, MO | 2 |
| Ramalho, MJ | 1 |
| Sevin, E | 1 |
| Gosselet, F | 1 |
| Lima, J | 1 |
| Coelho, MAN | 1 |
| Loureiro, JA | 1 |
| Pereira, MC | 1 |
| Duan, K | 1 |
| Liu, ZJ | 1 |
| Hu, SQ | 1 |
| Huo, HY | 1 |
| Xu, ZR | 1 |
| Ruan, JF | 1 |
| Sun, Y | 1 |
| Dai, LP | 1 |
| Yan, CB | 1 |
| Xiong, W | 1 |
| Cui, QH | 1 |
| Yu, HJ | 1 |
| Yu, M | 1 |
| Qin, Y | 1 |
| Kriel, J | 1 |
| Müller-Nedebock, K | 1 |
| Maarman, G | 1 |
| Mbizana, S | 1 |
| Ojuka, E | 1 |
| Klumperman, B | 1 |
| Loos, B | 1 |
| Zhao, M | 2 |
| Danhier, F | 2 |
| Bastiancich, C | 2 |
| Joudiou, N | 2 |
| Ganipineni, LP | 2 |
| Tsakiris, N | 1 |
| Gallez, B | 2 |
| Rieux, AD | 1 |
| Jankovski, A | 1 |
| Bianco, J | 2 |
| Préat, V | 2 |
| Ucakar, B | 1 |
| Danhier, P | 1 |
| El Sayed, SM | 2 |
| Baghdadi, H | 1 |
| Ahmed, NS | 1 |
| Almaramhy, HH | 1 |
| Mahmoud, AA | 1 |
| El-Sawy, SA | 1 |
| Ayat, M | 1 |
| Elshazley, M | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Treatment Development of Triheptanoin for Glucose Transporter Type I Deficiency[NCT02021526] | Phase 1/Phase 2 | 0 participants (Actual) | Interventional | 2015-12-31 | Withdrawn (stopped due to NIH funding resulted in new clinical trial) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for lactic acid and Glioblastoma
| Article | Year |
|---|---|
Therapeutic Drug-Induced Metabolic Reprogramming in Glioblastoma.
Topics: Amino Acids; Fatty Acids; Glioblastoma; Glucose; Humans; Lactic Acid; Oxidative Phosphorylation | 2022 |
New metabolic imaging tools in neuro-oncology.
Topics: Brain Neoplasms; Deuterium; Glioblastoma; Glycolysis; Humans; Lactic Acid; Medical Oncology; Multimo | 2019 |
Cancer metabolism and mass spectrometry-based proteomics.
Topics: Animals; Cell Hypoxia; Glioblastoma; Glutamine; Glycolysis; Humans; Isoenzymes; L-Lactate Dehydrogen | 2015 |
Lactate Transporters and pH Regulation: Potential Therapeutic Targets in Glioblastomas.
Topics: Animals; Brain Neoplasms; Carbonic Anhydrases; Glioblastoma; Glycolysis; Humans; Hydrogen-Ion Concen | 2016 |
Image-guided 1H NMR spectroscopical and histological characterization of a human brain tumor model in the nude rat; a new approach to monitor changes in tumor metabolism.
Topics: Animals; Aspartic Acid; Brain Neoplasms; Choline; Energy Metabolism; Glioblastoma; Humans; Lactates; | 1992 |
1 trial available for lactic acid and Glioblastoma
| Article | Year |
|---|---|
Evaluation of the lactate-to-N-acetyl-aspartate ratio defined with magnetic resonance spectroscopic imaging before radiation therapy as a new predictive marker of the site of relapse in patients with glioblastoma multiforme.
Topics: Adult; Aged; Antineoplastic Agents; Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; Choline; Crea | 2014 |
105 other studies available for lactic acid and Glioblastoma
| Article | Year |
|---|---|
NOX4-derived ROS-induced overexpression of FOXM1 regulates aerobic glycolysis in glioblastoma.
Topics: Adenosine Triphosphate; Animals; Blotting, Western; Brain; Brain Neoplasms; Cell Line, Tumor; Forkhe | 2021 |
PI3K Pathway Inhibition with NVP-BEZ235 Hinders Glycolytic Metabolism in Glioblastoma Multiforme Cells.
Topics: Brain Neoplasms; Cell Line, Tumor; Forkhead Box Protein O1; Gene Expression Regulation, Neoplastic; | 2021 |
Surface Modification of Nanoparticles Enhances Drug Delivery to the Brain and Improves Survival in a Glioblastoma Multiforme Murine Model.
Topics: Animals; Brain; Cell Line, Tumor; Disease Models, Animal; Drug Carriers; Drug Delivery Systems; Glio | 2022 |
Metabolic Reprogramming of Glioblastoma Cells during HCMV Infection Induces Secretome-Mediated Paracrine Effects in the Microenvironment.
Topics: Cell Line, Tumor; Cytomegalovirus; Cytomegalovirus Infections; Glioblastoma; Glycolysis; Humans; Lac | 2022 |
Imaging biomarkers of TERT or GABPB1 silencing in TERT-positive glioblastoma.
Topics: Biomarkers; Carbon Isotopes; GA-Binding Protein Transcription Factor; Glioblastoma; Humans; Lactic A | 2022 |
Lactate modulates microglia polarization via IGFBP6 expression and remodels tumor microenvironment in glioblastoma.
Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Glioblastoma; Hedgehog Proteins; Humans; Insulin-Like Gr | 2023 |
Deuterium Metabolic Imaging Reports on TERT Expression and Early Response to Therapy in Cancer.
Topics: Animals; Deuterium; Glioblastoma; Lactic Acid; Mice; NAD; Pyruvic Acid; Telomerase | 2022 |
Esterase-responsive and size-optimized prodrug nanoparticles for effective intracranial drug delivery and glioblastoma treatment.
Topics: Animals; Cell Line, Tumor; Drug Carriers; Drug Delivery Systems; Esterases; Glioblastoma; Lactic Aci | 2022 |
Imaging Glioblastoma Metabolism by Using Hyperpolarized [1-
Topics: Bicarbonates; Glioblastoma; Humans; Lactate Dehydrogenase 5; Lactic Acid; Male; Middle Aged; Prospec | 2022 |
Lactate is an epigenetic metabolite that drives survival in model systems of glioblastoma.
Topics: Acetylation; Animals; Cell Line, Tumor; Epigenesis, Genetic; Glioblastoma; Histones; Humans; Lactic | 2022 |
Quantitative measurement of peritumoral concentrations of glutamate, N-acetyl aspartate, and lactate on magnetic resonance spectroscopy predicts glioblastoma-related refractory epilepsy.
Topics: Aspartic Acid; Creatine; Drug Resistant Epilepsy; Epilepsy, Temporal Lobe; Glioblastoma; Glutamic Ac | 2022 |
Lactate dehydrogenases promote glioblastoma growth and invasion via a metabolic symbiosis.
Topics: Animals; Brain Neoplasms; Glioblastoma; Lactate Dehydrogenases; Lactic Acid; Metabolomics; Mice | 2022 |
Tumor-secreted lactate contributes to an immunosuppressive microenvironment and affects CD8 T-cell infiltration in glioblastoma.
Topics: Brain Neoplasms; CD8-Positive T-Lymphocytes; Glioblastoma; Humans; Immunosuppressive Agents; Lactic | 2023 |
Topics: Animals; Brain; Brain Mapping; Cell Line, Tumor; Diagnostic Imaging; gamma-Aminobutyric Acid; Gliobl | 2020 |
A New Pathway Promotes Adaptation of Human Glioblastoma Cells to Glucose Starvation.
Topics: Adaptation, Physiological; Benzimidazoles; Brain Neoplasms; Cell Line, Tumor; Endocytosis; Glioblast | 2020 |
Dual inhibition of PFKFB3 and VEGF normalizes tumor vasculature, reduces lactate production, and improves chemotherapy in glioblastoma: insights from protein expression profiling and MRI.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Bevacizumab; Brain; Brain Neopla | 2020 |
Lactate as clinical tumour biomarker: Optimization of lactate detection and quantification in MR spectroscopic imaging of glioblastomas.
Topics: Adult; Aged; Biomarkers, Tumor; Brain; Brain Neoplasms; Feasibility Studies; Female; Glioblastoma; H | 2020 |
Different Mechanisms Underlie the Metabolic Response of GBM Stem-Like Cells to Ionizing Radiation: Biological and MRS Studies on Effects of Photons and Carbon Ions.
Topics: Brain Neoplasms; Cell Line, Tumor; G2 Phase Cell Cycle Checkpoints; gamma-Aminobutyric Acid; Gliobla | 2020 |
Intratumoral Distribution of Lactate and the Monocarboxylate Transporters 1 and 4 in Human Glioblastoma Multiforme and Their Relationships to Tumor Progression-Associated Markers.
Topics: Adult; Aged; Biomarkers, Tumor; Brain Neoplasms; Cell Line, Tumor; Disease Progression; Epithelial-M | 2020 |
Hyperpolarized
Topics: Aerobiosis; Animals; Aspartic Acid; Brain Neoplasms; Carbon Isotopes; Cell Line, Tumor; Glioblastoma | 2021 |
Controlling the release rate of topotecan from PLGA spheres and increasing its cytotoxicity towards glioblastoma cells by co-loading with calcium chloride.
Topics: Calcium Chloride; Glioblastoma; Humans; Lactic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; To | 2021 |
Detection of metabolic change in glioblastoma cells after radiotherapy using hyperpolarized
Topics: Animals; Carbon-13 Magnetic Resonance Spectroscopy; Cell Line, Tumor; Glioblastoma; Humans; Lactate | 2021 |
Prediction of Glioma Stemlike Cell Infiltration in the Non-Contrast-Enhancing Area by Quantitative Measurement of Lactate on Magnetic Resonance Spectroscopy in Glioblastoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherap | 2021 |
Tumortropic adipose-derived stem cells carrying smart nanotherapeutics for targeted delivery and dual-modality therapy of orthotopic glioblastoma.
Topics: Adipocytes; Animals; Antineoplastic Agents; Biological Transport; Blood-Brain Barrier; Brain Neoplas | 2017 |
Delivery of doxorubicin-loaded PLGA nanoparticles into U87 human glioblastoma cells.
Topics: Blood-Brain Barrier; Cell Line, Tumor; Doxorubicin; Drug Liberation; Glioblastoma; Humans; Lactic Ac | 2017 |
Intraoperative serum lactate is not a predictor of survival after glioblastoma surgery.
Topics: Adult; Aged; Brain Neoplasms; Disease-Free Survival; Female; Glioblastoma; Humans; Lactic Acid; Male | 2017 |
Upregulation of mitochondrial NAD
Topics: Aging; Animals; Brain Neoplasms; Cell Differentiation; Cell Line, Tumor; Colony-Forming Units Assay; | 2017 |
Disruption of the monocarboxylate transporter-4-basigin interaction inhibits the hypoxic response, proliferation, and tumor progression.
Topics: Acriflavine; Animals; Basigin; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Disease | 2017 |
In vitro nuclear magnetic resonance spectroscopy metabolic biomarkers for the combination of temozolomide with PI3K inhibition in paediatric glioblastoma cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Brain Neoplasms; Cell Line, Tumor | 2017 |
Receptor-mediated PLGA nanoparticles for glioblastoma multiforme treatment.
Topics: Antibodies, Monoclonal; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Cell P | 2018 |
Lactic acid induces lactate transport and glycolysis/OXPHOS interconversion in glioblastoma.
Topics: Adenosine Triphosphate; Biological Transport; Blotting, Western; Cell Line, Tumor; Glioblastoma; Gly | 2018 |
Coordinated autophagy modulation overcomes glioblastoma chemoresistance through disruption of mitochondrial bioenergetics.
Topics: Antineoplastic Agents; Autophagy; Autophagy-Related Protein 5; Brain Neoplasms; Cell Line, Tumor; Ce | 2018 |
Post-resection treatment of glioblastoma with an injectable nanomedicine-loaded photopolymerizable hydrogel induces long-term survival.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Delayed-Ac | 2018 |
Magnetic targeting of paclitaxel-loaded poly(lactic-
Topics: Animals; Blood-Brain Barrier; Cell Line, Tumor; Endocytosis; Female; Glioblastoma; Humans; Lactic Ac | 2018 |
Dichloroacetate is an antimetabolite that antagonizes acetate and deprives cancer cells from its benefits: A novel evidence-based medical hypothesis.
Topics: Acetates; Acetyl Coenzyme A; Animals; Antineoplastic Agents; Brain Neoplasms; Chlorides; Dichloroace | 2019 |
Verteporfin-Loaded Polymeric Microparticles for Intratumoral Treatment of Brain Cancer.
Topics: Animals; Brain Neoplasms; Glioblastoma; Humans; Lactic Acid; Male; Mice; Mice, Nude; Microspheres; P | 2019 |
Nuclear Magnetic Resonance Spectroscopy to Identify Metabolite Biomarkers of Nonresponsiveness to Targeted Therapy in Glioblastoma Tumor Stem Cells.
Topics: Antineoplastic Agents; Biomarkers, Pharmacological; Brain Neoplasms; Cell Survival; Citric Acid; Cit | 2019 |
A "drug cocktail" delivered by microspheres for the local treatment of rat glioblastoma.
Topics: Acridines; Animals; Antineoplastic Agents, Phytogenic; Celecoxib; Cyclooxygenase 2 Inhibitors; Drug | 2013 |
Inhibition of monocarboxylate transporter-4 depletes stem-like glioblastoma cells and inhibits HIF transcriptional response in a lactate-independent manner.
Topics: Animals; Apoptosis; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, | 2014 |
Multilayered polymer-coated carbon nanotubes to deliver dasatinib.
Topics: Cell Proliferation; Dasatinib; Drug Delivery Systems; Glioblastoma; Humans; Kinetics; Lactic Acid; M | 2014 |
Double-effective chitosan scaffold-PLGA nanoparticle system for brain tumour therapy: in vitro study.
Topics: Antimetabolites, Antineoplastic; Brain Neoplasms; Cell Line, Tumor; Chitosan; Drug Carriers; Fluorou | 2014 |
New celecoxib multiparticulate systems to improve glioblastoma treatment.
Topics: Animals; Brain Neoplasms; Celecoxib; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 2 Inhibito | 2014 |
Lactate and choline metabolites detected in vitro by nuclear magnetic resonance spectroscopy are potential metabolic biomarkers for PI3K inhibition in pediatric glioblastoma.
Topics: Cell Line, Tumor; Choline; Flow Cytometry; Glioblastoma; Humans; Immunoblotting; Lactic Acid; Magnet | 2014 |
Surgical delivery of drug releasing poly(lactic-co-glycolic acid)/poly(ethylene glycol) paste with in vivo effects against glioblastoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Biopsy, Needle; Brain Neoplasms; Disease Mo | 2014 |
Glucose-lactate metabolic cooperation in cancer: insights from a spatial mathematical model and implications for targeted therapy.
Topics: Cell Line, Tumor; Glioblastoma; Glucose; Humans; Lactic Acid; Models, Biological | 2014 |
Bevacizumab treatment induces metabolic adaptation toward anaerobic metabolism in glioblastomas.
Topics: Adult; Aged; Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal, Humanized; Bevacizumab; Brain | 2015 |
Imaging the delivery of brain-penetrating PLGA nanoparticles in the brain using magnetic resonance.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Convection; Drug Delivery Systems; Ferric Compounds | 2015 |
Development of disulfiram-loaded poly(lactic-co-glycolic acid) wafers for the localised treatment of glioblastoma multiforme: a comparison of manufacturing techniques.
Topics: Antineoplastic Agents; Brain Neoplasms; Calorimetry, Differential Scanning; Cell Line, Tumor; Cell S | 2015 |
Targeting delivery of etoposide to inhibit the growth of human glioblastoma multiforme using lactoferrin- and folic acid-grafted poly(lactide-co-glycolide) nanoparticles.
Topics: Antineoplastic Agents, Phytogenic; Astrocytes; Blood-Brain Barrier; Brain Neoplasms; Cell Line, Tumo | 2015 |
Decitabine nanoconjugate sensitizes human glioblastoma cells to temozolomide.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Apoptosis; Azacitidine; Biocompa | 2015 |
Fenofibrate subcellular distribution as a rationale for the intracranial delivery through biodegradable carrier.
Topics: Animals; Biodegradable Plastics; Brain; Brain Neoplasms; Cell Line, Tumor; Drug Carriers; Female; Fe | 2015 |
The effect of AZD2171- or sTRAIL/Apo2L-loaded polylactic-co-glycolic acid microspheres on a subcutaneous glioblastoma model.
Topics: Animals; Cell Line, Tumor; Delayed-Action Preparations; Disease Models, Animal; Glioblastoma; Glycol | 2015 |
Convection-Enhanced Delivery of Carboplatin PLGA Nanoparticles for the Treatment of Glioblastoma.
Topics: Animals; Carboplatin; Cell Death; Cell Line, Tumor; Cells, Cultured; Convection; Drug Delivery Syste | 2015 |
Hot melt extruded and injection moulded disulfiram-loaded PLGA millirods for the treatment of glioblastoma multiforme via stereotactic injection.
Topics: Brain Neoplasms; Cell Line, Tumor; Disulfiram; Drug Carriers; Drug Delivery Systems; Freezing; Gliob | 2015 |
Salinomycin encapsulated nanoparticles as a targeting vehicle for glioblastoma cells.
Topics: Cell Line, Tumor; Delayed-Action Preparations; Glioblastoma; Humans; Lactic Acid; Polyglycolic Acid; | 2016 |
Influence of Serum and Hypoxia on Incorporation of [(14)C]-D-Glucose or [(14)C]-L-Glutamine into Lipids and Lactate in Murine Glioblastoma Cells.
Topics: Animals; Carbon Radioisotopes; Cattle; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Cholester | 2015 |
The tumor-targeting core-shell structured DTX-loaded PLGA@Au nanoparticles for chemo-photothermal therapy and X-ray imaging.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Chlorides; Contrast Media; Docetaxel; Drug Carrier | 2015 |
A Combined Approach Employing Chlorotoxin-Nanovectors and Low Dose Radiation To Reach Infiltrating Tumor Niches in Glioblastoma.
Topics: Animals; Blood-Brain Barrier; Brain Neoplasms; Cell Line, Tumor; Chemoradiotherapy; Chloride Channel | 2016 |
Evaluation of cytotoxic and tumor targeting capability of (177)Lu-DOTATATE-nanoparticles: a trailblazing strategy in peptide receptor radionuclide therapy.
Topics: Animals; Antibodies, Monoclonal; Cell Line, Tumor; Chorionic Gonadotropin, beta Subunit, Human; Feas | 2016 |
Temozolomide-loaded PLGA nanoparticles to treat glioblastoma cells: a biophysical and cell culture evaluation.
Topics: Biophysical Phenomena; Cell Line, Tumor; Cell Survival; Dacarbazine; Dose-Response Relationship, Dru | 2016 |
Distribution of polymer nanoparticles by convection-enhanced delivery to brain tumors.
Topics: Animals; Brain; Brain Neoplasms; Cell Line, Tumor; Convection; Drug Delivery Systems; Glioblastoma; | 2016 |
Investigation of imatinib loaded surface decorated biodegradable nanocarriers against glioblastoma cell lines: Intracellular uptake and cytotoxicity studies.
Topics: Cell Line, Tumor; Cell Survival; Drug Carriers; Drug Liberation; Glioblastoma; Humans; Imatinib Mesy | 2016 |
Maleic anhydride proton sponge as a novel MALDI matrix for the visualization of small molecules (<250 m/z) in brain tumors by routine MALDI ToF imaging mass spectrometry.
Topics: Brain; Brain Neoplasms; Chlorides; Glioblastoma; Glutarates; Humans; Lactic Acid; Maleic Anhydrides; | 2016 |
Advanced interstitial chemotherapy combined with targeted treatment of malignant glioma in rats by using drug-loaded nanofibrous membranes.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bibenzyls; Brain; Brain Neoplasms; Camptoth | 2016 |
Tailored Nanoparticle Codelivery of antimiR-21 and antimiR-10b Augments Glioblastoma Cell Kill by Temozolomide: Toward a "Personalized" Anti-microRNA Therapy.
Topics: Cell Cycle; Cell Line, Tumor; Cell Survival; Dacarbazine; Glioblastoma; Humans; Lactic Acid; MicroRN | 2016 |
pH, Lactate, and Hypoxia: Reciprocity in Regulating High-Affinity Monocarboxylate Transporter Expression in Glioblastoma.
Topics: Astrocytes; Cell Hypoxia; Cell Line, Tumor; Cells, Cultured; Gene Expression; Gene Expression Regula | 2017 |
Anti-GD2-ch14.18/CHO coated nanoparticles mediate glioblastoma (GBM)-specific delivery of the aromatase inhibitor, Letrozole, reducing proliferation, migration and chemoresistance in patient-derived GBM tumor cells.
Topics: Antibodies, Monoclonal; Antineoplastic Agents; Aromatase Inhibitors; Brain Neoplasms; Cell Line, Tum | 2017 |
Three weeks release BCNU loaded hydrophilic-PLGA microspheres for interstitial chemotherapy: Development and activity against human glioblastoma cells.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Carmustine; Cell Survival; Drug Carriers; Gliobl | 2008 |
Relationship of pre-surgery metabolic and physiological MR imaging parameters to survival for patients with untreated GBM.
Topics: Adult; Aged; Aspartic Acid; Brain Mapping; Brain Neoplasms; Choline; Creatine; Diagnosis, Differenti | 2009 |
Paclitaxel delivery from PLGA foams for controlled release in post-surgical chemotherapy against glioblastoma multiforme.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Brain Neoplasms; Cell Division; Cell Line, Tu | 2009 |
The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism.
Topics: Aerobiosis; Alternative Splicing; Animals; Cell Line; Cell Line, Tumor; Exons; Glioblastoma; Glycoly | 2010 |
Noninvasive detection of target modulation following phosphatidylinositol 3-kinase inhibition using hyperpolarized 13C magnetic resonance spectroscopy.
Topics: Animals; Carbon Isotopes; Chromones; Drug Delivery Systems; Enzyme Inhibitors; Everolimus; Glioblast | 2010 |
Intracellular drug delivery using polysorbate 80-modified poly(D,L-lactide-co-glycolide) nanospheres to glioblastoma cells.
Topics: Antibiotics, Antineoplastic; Brain Neoplasms; Cell Line, Tumor; Cell Membrane Permeability; Cell Pro | 2011 |
Biocompatible and pH-sensitive PLGA encapsulated MnO nanocrystals for molecular and cellular MRI.
Topics: Biocompatible Materials; Cell Line, Tumor; Cell Tracking; Contrast Media; Glioblastoma; Humans; Hydr | 2011 |
[2,4-(13)C]β-hydroxybutyrate metabolism in astrocytes and C6 glioblastoma cells.
Topics: 3-Hydroxybutyric Acid; Animals; Aspartic Acid; Astrocytes; Brain Neoplasms; Citric Acid Cycle; Diet, | 2011 |
Efficient chemotherapy of rat glioblastoma using doxorubicin-loaded PLGA nanoparticles with different stabilizers.
Topics: Animals; Calorimetry, Differential Scanning; Doxorubicin; Glial Fibrillary Acidic Protein; Glioblast | 2011 |
Detection of early response to temozolomide treatment in brain tumors using hyperpolarized 13C MR metabolic imaging.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Carbon Isotopes; Cell Line, Tumor; Daca | 2011 |
Nanotextured substrates with immobilized aptamers for cancer cell isolation and cytology.
Topics: Aptamers, Nucleotide; Brain Neoplasms; Cell Separation; Cells, Cultured; Cytodiagnosis; Cytological | 2012 |
Reduced phosphocholine and hyperpolarized lactate provide magnetic resonance biomarkers of PI3K/Akt/mTOR inhibition in glioblastoma.
Topics: Antineoplastic Agents; Biomarkers; Cell Line, Tumor; Chromones; Enzyme Inhibitors; Everolimus; Gliob | 2012 |
3-Bromopyruvate antagonizes effects of lactate and pyruvate, synergizes with citrate and exerts novel anti-glioma effects.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Cell Survival; Citric Acid; D-Amino-Acid Oxidase; Elec | 2012 |
Glucose metabolism via the pentose phosphate pathway, glycolysis and Krebs cycle in an orthotopic mouse model of human brain tumors.
Topics: Animals; Brain Neoplasms; Carcinoma, Renal Cell; Citric Acid Cycle; Disease Models, Animal; gamma-Am | 2012 |
Preparation and characterization of teniposide PLGA nanoparticles and their uptake in human glioblastoma U87MG cells.
Topics: Acetone; Antineoplastic Agents; Calorimetry, Differential Scanning; Cell Line, Tumor; Cell Survival; | 2012 |
Smart multifunctional core-shell nanospheres with drug and gene co-loaded for enhancing the therapeutic effect in a rat intracranial tumor model.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Drug Carriers; Dru | 2012 |
ENTPD5-mediated modulation of ATP results in altered metabolism and decreased survival in gliomablastoma multiforme.
Topics: Adenosine Triphosphate; Animals; Autophagy; Blotting, Western; Brain; Brain Neoplasms; Cell Prolifer | 2012 |
EGFR-induced and PKCε monoubiquitylation-dependent NF-κB activation upregulates PKM2 expression and promotes tumorigenesis.
Topics: Animals; Brain Neoplasms; Carrier Proteins; Cell Line, Tumor; Cell Transformation, Neoplastic; Enzym | 2012 |
Brain abscess and glioblastoma identified by combined proton magnetic resonance spectroscopy and diffusion-weighted magnetic resonance imaging--two case reports.
Topics: Acetates; Adult; Amino Acids; Aspartic Acid; Brain Abscess; Brain Neoplasms; Diagnosis, Differential | 2002 |
Metabolic profiles of human brain tumors using quantitative in vivo 1H magnetic resonance spectroscopy.
Topics: Alanine; Aspartic Acid; Astrocytoma; Brain Neoplasms; Choline; Creatine; Glioblastoma; Humans; Inosi | 2003 |
Combination of single-voxel proton MR spectroscopy and apparent diffusion coefficient calculation in the evaluation of common brain tumors.
Topics: Adolescent; Adult; Aged; Alanine; Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Choline; Creat | 2003 |
Proton magnetic resonance spectroscopy imaging in the evaluation of patients undergoing gamma knife surgery for Grade IV glioma.
Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain; Brain Mapping; Brain Neoplasms; Choline; Cohor | 2004 |
Continuous delivery of endogenous inhibitors from poly(lactic-co-glycolic acid) polymeric microspheres inhibits glioma tumor growth.
Topics: Animals; Biocompatible Materials; Brain Neoplasms; Cattle; Coagulants; Drug Delivery Systems; Endoth | 2005 |
Detection and differentiation of lactate and lipids by single-voxel proton MR spectroscopy.
Topics: Aged; Algorithms; Brain Chemistry; Brain Neoplasms; Female; Glioblastoma; Humans; Lactic Acid; Lipid | 2005 |
Independent component analysis to proton spectroscopic imaging data of human brain tumours.
Topics: Algorithms; Aspartic Acid; Astrocytoma; Brain Neoplasms; Cell Proliferation; Choline; Creatine; Glio | 2005 |
In vivo fate and therapeutic efficacy of PF-4/CTF microspheres in an orthotopic human glioblastoma model.
Topics: Animals; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Glioblastoma; Humans; Lactic A | 2008 |
Interstitial chemotherapy with biodegradable ACNU pellet for glioblastoma.
Topics: Adult; Aged; Animals; Biodegradation, Environmental; Brain Neoplasms; Drug Implants; Female; Gliobla | 1994 |
Imaging brain tumors -- beyond three dimensions.
Topics: Aged; Alanine; Brain Neoplasms; Choline; Female; Glioblastoma; Humans; Lactates; Lactic Acid; Magnet | 1996 |
Alterations of lactate (+lipid) concentration in brain tumors with in vivo hydrogen magnetic resonance spectroscopy during radiotherapy.
Topics: Adult; Aged; Aged, 80 and over; Brain Chemistry; Brain Neoplasms; Female; Glioblastoma; Humans; Lact | 1997 |
Classification of biopsy-confirmed brain tumors using single-voxel MR spectroscopy.
Topics: Adult; Aged; Analysis of Variance; Aspartic Acid; Astrocytoma; Biopsy; Body Water; Brain Neoplasms; | 1999 |
A preliminary study of the prognostic value of proton magnetic resonance spectroscopic imaging in gamma knife radiosurgery of recurrent malignant gliomas.
Topics: Adult; Aged; Aspartic Acid; Astrocytoma; Choline; Creatine; Female; Glioblastoma; Humans; Lactic Aci | 2000 |
Effect of voxel position on single-voxel MR spectroscopy findings.
Topics: Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Choline; Creatine; Diagnosis, Differential; Glio | 2000 |
Paclitaxel loaded poly(L-lactic acid) microspheres for the prevention of intraperitoneal carcinomatosis after a surgical repair and tumor cell spill.
Topics: Animals; Carbon Dioxide; Cecum; Drug Delivery Systems; Glioblastoma; Insufflation; Intraoperative Co | 2000 |
Proton magnetic resonance chemical shift imaging (1H CSI)-directed stereotactic biopsy.
Topics: Adult; Aspartic Acid; Biopsy, Needle; Brain; Brain Neoplasms; Creatine; Diagnosis, Differential; Ene | 2001 |
An efficient chemical shift imaging scheme for magnetic resonance-guided neurosurgery.
Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Astrocytoma; Biopsy; Brain; Brain Mapping; Brain Neop | 2001 |
Differentiation between high-grade glioma and metastatic brain tumor using single-voxel proton MR spectroscopy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Chil | 2001 |
Improved analysis of 1H-MR spectra in the presence of mobile lipids.
Topics: Alanine; Artifacts; Brain; Brain Diseases; Brain Neoplasms; Glioblastoma; Glioma; Humans; Image Enha | 2001 |
Effects of NFkappaB decoy oligonucleotides released from biodegradable polymer microparticles on a glioblastoma cell line.
Topics: Active Transport, Cell Nucleus; Biocompatible Materials; Biodegradation, Environmental; Blotting, We | 2002 |