lactic acid has been researched along with Glioblastoma with Sarcomatous Component in 6 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Since lonidamine (LND) is believed to reduce tumor glucose utilization by inhibition of the mitochondrially-bound glycolytic enzyme hexokinase (HK), 31P magnetic resonance spectroscopy (MRS) was used to noninvasively follow the effects of LND on both tumor pH and the high-energy phosphate metabolites: ATP, phosphocreatine (PCr) and inorganic phosphate (Pi) in subcutaneous rat 9L gliosarcomas." | 3.70 | Mechanism of action of lonidamine in the 9L brain tumor model involves inhibition of lactate efflux and intracellular acidification. ( Ben-Yoseph, O; Lyons, JC; Ross, BD; Song, CW, 1998) |
| "Gliosarcoma is an uncommon variant of glioblastoma multiforme, which is composed of gliomatous and sarcomatous elements." | 1.35 | Giant infantile gliosarcoma: magnetic resonance imaging findings. ( Bulakbasi, N; Chen, L; Kocaoglu, M; Onguru, O; Sanal, HT, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 4 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, JS | 2 |
| An, TK | 1 |
| Chae, GS | 2 |
| Jeong, JK | 1 |
| Cho, SH | 1 |
| Lee, HB | 2 |
| Khang, G | 2 |
| Kim, SH | 1 |
| Seo, KS | 1 |
| Kim, MS | 1 |
| Kim, GY | 1 |
| Tyler, BM | 1 |
| Tupper, MM | 1 |
| Karp, JM | 1 |
| Langer, RS | 1 |
| Brem, H | 1 |
| Cima, MJ | 1 |
| Sanal, HT | 1 |
| Bulakbasi, N | 1 |
| Kocaoglu, M | 1 |
| Onguru, O | 1 |
| Chen, L | 1 |
| Kong, Q | 1 |
| Kleinschmidt-Demasters, BK | 1 |
| Lillehei, KO | 1 |
| Ben-Yoseph, O | 1 |
| Lyons, JC | 1 |
| Song, CW | 1 |
| Ross, BD | 1 |
6 other studies available for lactic acid and Glioblastoma with Sarcomatous Component
| Article | Year |
|---|---|
Evaluation of in vitro and in vivo antitumor activity of BCNU-loaded PLGA wafer against 9L gliosarcoma.
Topics: Animals; Antineoplastic Agents; Carmustine; Cell Line, Tumor; Cell Survival; Drug Evaluation, Precli | 2005 |
Enhancement of the stability of BCNU using self-emulsifying drug delivery systems (SEDDS) and in vitro antitumor activity of self-emulsified BCNU-loaded PLGA wafer.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Carmustine; Cell Line, Tumor; Cell Survival; Dru | 2005 |
Resorbable polymer microchips releasing BCNU inhibit tumor growth in the rat 9L flank model.
Topics: Animals; Antineoplastic Agents, Alkylating; Biocompatible Materials; Carmustine; Chemistry, Pharmace | 2007 |
Giant infantile gliosarcoma: magnetic resonance imaging findings.
Topics: Aspartic Acid; Brain; Brain Neoplasms; Child, Preschool; Choline; Creatinine; Female; Gliosarcoma; H | 2008 |
Intralesionally implanted cisplatin cures primary brain tumor in rats.
Topics: Animals; Brain Neoplasms; Cisplatin; Delayed-Action Preparations; Drug Implants; Gliosarcoma; Lactic | 1997 |
Mechanism of action of lonidamine in the 9L brain tumor model involves inhibition of lactate efflux and intracellular acidification.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Gliosarcoma; Hydrogen-Ion Concentration; Indazoles; | 1998 |