lactic acid has been researched along with Glial Cell Tumors in 199 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We performed serial (1)H-MRSI examinations to assess intratumoral metabolite intensities in 16 patients receiving high-dose oral tamoxifen monotherapy for recurrent malignant glioma (WHO grade III or IV) as part of a phase II clinical trial." | 9.13 | Prospective serial proton MR spectroscopic assessment of response to tamoxifen for recurrent malignant glioma. ( Arnold, DL; Assina, R; Caramanos, Z; Langleben, A; Leblanc, R; Preul, MC; Sankar, T; Villemure, JG, 2008) |
| "We aimed to evaluate the antitumor activity of curcumin on glioblastoma tissue in the rat glioma-2 (RG2) tumor model when it is loaded on poly(lactic-co-glycolic acid)-1,2-distearoyl-glycerol-3-phospho-ethanolamine-N-[methoxy (polyethylene glycol)-2000] ammonium salt (PLGA-DSPE-PEG) hybrid nanoparticles." | 7.85 | Effects of curcumin-loaded PLGA nanoparticles on the RG2 rat glioma model. ( Kaffashi, A; Mut, M; Oğuz, KK; Orunoğlu, M; Pehlivan, SB; Şahin, S; Söylemezoğlu, F, 2017) |
| " In this study, we examined the effects of transferrin (Tf)-modified poly ethyleneglycol-poly lactic acid (PEG-PLA) nanoparticles conjugated with resveratrol (Tf-PEG-PLA-RSV) to glioma therapy in vitro and in vivo." | 7.79 | Transferrin modified PEG-PLA-resveratrol conjugates: in vitro and in vivo studies for glioma. ( Dai, H; Guo, W; Jia, Z; Li, A; Li, H; Yuan, Y, 2013) |
| "In this study, we investigated the effects of temozolomide (TMZ)/Poly (lactide-co-glycolide)(PLGA)/nano-hydroxyapatite microspheres on the behavior of U87 glioma cells." | 7.78 | The effect of temozolomide/poly(lactide-co-glycolide) (PLGA)/nano-hydroxyapatite microspheres on glioma U87 cells behavior. ( Qiu, B; Tian, A; Wang, M; Wu, A; Xue, X; Zhang, D, 2012) |
| "Polysorbate 80 coated temozolomide-loaded PLGA-based superparamagnetic nanoparticles (P80-TMZ/SPIO-NPs) were successfully synthesized and characterized as drug carriers and diagnosis agent for malignant brain glioma." | 7.78 | Temozolomide loaded PLGA-based superparamagnetic nanoparticles for magnetic resonance imaging and treatment of malignant glioma. ( Ling, Y; Wei, K; Zhong, S; Zou, F, 2012) |
| "Implantable and poly (d,l-lactide-co-glycolide) (PLGA) microparticles were developed to deliver temozolomide (TM) continuously in interstitial chemotherapy for glioma." | 7.77 | Temozolomide/PLGA microparticles: a new protocol for treatment of glioma in rats. ( Liu, JM; Yue, ZJ; Zhang, H; Zhang, YH, 2011) |
| "Temozolomide (TM) has anti-tumor activity in patients with malignant glioma." | 7.76 | Temozolomide/PLGA microparticles plus vatalanib inhibits tumor growth and angiogenesis in an orthotopic glioma model. ( Liu, JM; Tang, GS; Wang, Y; Yue, ZJ; Zhang, H; Zhang, YH, 2010) |
| "In an effort to develop new therapeutic strategies to treat malignant gliomas, we have designed poly (lactic-co-glycolic) acid (PLGA) microparticles that deliver imatinib mesylate, a small molecule tyrosine kinase inhibitor." | 7.75 | Local delivery of poly lactic-co-glycolic acid microspheres containing imatinib mesylate inhibits intracranial xenograft glioma growth. ( Ariel, G; Benny, O; Black, PM; Carroll, RS; Goren, E; Kim, SK; Machluf, M; Menon, LG; Stewman, C, 2009) |
| "Transferrin (Tf), an iron-transporting serum glycoprotein, which binds to receptors expressed at the surface of most proliferating cells with particularly high expression on erythroblasts and cancer cells, was chosen as the ligand to develop BCNU-loaded biodegradable poly(D,L-lactic acid) nanoparticles (NPs) containing a ligand, which specifically binds to glioma cells, and their anti-tumor ability was evaluated using a C6 glioma model." | 7.75 | Growth inhibition against intracranial C6 glioma cells by stereotactic delivery of BCNU by controlled release from poly(D,L-lactic acid) nanoparticles. ( Albadany, A; Chang, J; Guo, Y; Kang, C; Li, Y; Pu, P; Sheng, J; Yu, S; Yuan, X; Zhang, Z; Zhong, Y, 2009) |
| "The purpose of the present study was to develop implantable poly(D,L-lactide-co-glycolide) (PLGA) microparticles for continuous delivery of intact 3,4-dihydro-3-methyl-4-oxoimidazo[5,1-d]-as-tetrazine-8-carboxamide (temozolomide, TM) for about a 1-month period and to evaluate its cytotoxicity against Glioma C6 cancer cells." | 7.74 | Temozolomide/PLGA microparticles and antitumor activity against glioma C6 cancer cells in vitro. ( Gao, S; Zhang, H, 2007) |
| "The question as to whether glutamine and glucose are both required for optimal growth of glioma cells is studied through the role of these substrates on the metabolism of the cells." | 7.69 | Glucose and glutamine metabolism in C6 glioma cells studied by carbon 13 NMR. ( Canioni, P; Merle, M; Portais, JC; Voisin, P, 1996) |
| "We examined the effect of lactic acid on cultured human glioma cell lines expressing glial fibrillary acidic protein (GFAP), vimentin and neuron-specific enolase (NSE)." | 7.68 | Contrary effect of lactic acid on expression of neuron-specific enolase and glial fibrillary acidic protein in human glioma cells. ( Fukui, M; Kitamura, K; Kuramitsu, M; Nakamura, T; Sawa, H; Takeshita, I, 1990) |
| " Systemically administered drugs are often poorly bioavailable in the brain, and drug efficacy within the central nervous system can be limited by peripheral toxicity." | 5.42 | Intravenous delivery of camptothecin-loaded PLGA nanoparticles for the treatment of intracranial glioma. ( Berens, ME; Chung, EP; Dhruv, HD; DiPerna, DM; Householder, KT; Sirianni, RW; Wohlleb, GM, 2015) |
| "Etoposide (VP-16) is a hydrophobic anticancer agent inhibiting Topoisomerase II, commonly used in pediatric brain chemotherapeutic schemes as mildly toxic." | 5.39 | Etoposide encapsulation in surface-modified poly(lactide-co-glycolide) nanoparticles strongly enhances glioma antitumor efficiency. ( Andry, MC; Callewaert, M; Dukic, S; Gafa, V; Molinari, M; Roullin, VG; Van Gulick, L; Vittier, M, 2013) |
| "Gliotoxins are a group of amino acids that are toxic to astrocytes, and are substrates of high-affinity sodium-dependent glutamate transporters." | 5.32 | Gliotoxins disrupt alanine metabolism and glutathione production in C6 glioma cells: a 13C NMR spectroscopic study. ( Brennan, L; Hewage, C; Malthouse, JP; McBean, GJ, 2004) |
| "We performed serial (1)H-MRSI examinations to assess intratumoral metabolite intensities in 16 patients receiving high-dose oral tamoxifen monotherapy for recurrent malignant glioma (WHO grade III or IV) as part of a phase II clinical trial." | 5.13 | Prospective serial proton MR spectroscopic assessment of response to tamoxifen for recurrent malignant glioma. ( Arnold, DL; Assina, R; Caramanos, Z; Langleben, A; Leblanc, R; Preul, MC; Sankar, T; Villemure, JG, 2008) |
| "To investigate the effect of lactic acid-induced upregulation of PLEKHA4 expression on biological behaviors of glioma cells and the possible molecular mechanism." | 4.31 | [Lactate-induced up-regulation of PLEKHA4 promotes proliferation and apoptosis of human glioma cells]. ( Chen, T; Wang, N; Xi, B; Xu, W; Ye, J, 2023) |
| "Nanoparticles containing mixed lipid monolayer shell, biodegradable polymer core and rabies virus glycoprotein (RVG) peptide as brain targeting ligand, were developed for brain targeted delivery of paclitaxel (PTX) to treat malignant glioma." | 3.85 | Targeted delivery of nano-PTX to the brain tumor-associated macrophages. ( Do, L; Dou, H; Payne, G; Rodriguez, J; Tao, Y; Thomas, T; Zou, L, 2017) |
| "We aimed to evaluate the antitumor activity of curcumin on glioblastoma tissue in the rat glioma-2 (RG2) tumor model when it is loaded on poly(lactic-co-glycolic acid)-1,2-distearoyl-glycerol-3-phospho-ethanolamine-N-[methoxy (polyethylene glycol)-2000] ammonium salt (PLGA-DSPE-PEG) hybrid nanoparticles." | 3.85 | Effects of curcumin-loaded PLGA nanoparticles on the RG2 rat glioma model. ( Kaffashi, A; Mut, M; Oğuz, KK; Orunoğlu, M; Pehlivan, SB; Şahin, S; Söylemezoğlu, F, 2017) |
| " In this study, we examined the effects of transferrin (Tf)-modified poly ethyleneglycol-poly lactic acid (PEG-PLA) nanoparticles conjugated with resveratrol (Tf-PEG-PLA-RSV) to glioma therapy in vitro and in vivo." | 3.79 | Transferrin modified PEG-PLA-resveratrol conjugates: in vitro and in vivo studies for glioma. ( Dai, H; Guo, W; Jia, Z; Li, A; Li, H; Yuan, Y, 2013) |
| "Polysorbate 80 coated temozolomide-loaded PLGA-based superparamagnetic nanoparticles (P80-TMZ/SPIO-NPs) were successfully synthesized and characterized as drug carriers and diagnosis agent for malignant brain glioma." | 3.78 | Temozolomide loaded PLGA-based superparamagnetic nanoparticles for magnetic resonance imaging and treatment of malignant glioma. ( Ling, Y; Wei, K; Zhong, S; Zou, F, 2012) |
| " The aim of this study was to evaluate the effect of methylglyoxal exposure, over short (1 and 3 h) and long term (24 h) periods, on glucose, glycine and lactate metabolism in C6 glioma cells, as well as investigate the glyoxalase system and AGEs formation." | 3.78 | Methylglyoxal alters glucose metabolism and increases AGEs content in C6 glioma cells. ( Bobermin, LD; de Souza, DF; Fontoura, JB; Gonçalves, CA; Hansen, F; Hoefel, AL; Leite, MC; Perry, ML; Silveira, Sda L; Tramontina, AC, 2012) |
| "In this study, we investigated the effects of temozolomide (TMZ)/Poly (lactide-co-glycolide)(PLGA)/nano-hydroxyapatite microspheres on the behavior of U87 glioma cells." | 3.78 | The effect of temozolomide/poly(lactide-co-glycolide) (PLGA)/nano-hydroxyapatite microspheres on glioma U87 cells behavior. ( Qiu, B; Tian, A; Wang, M; Wu, A; Xue, X; Zhang, D, 2012) |
| "Implantable and poly (d,l-lactide-co-glycolide) (PLGA) microparticles were developed to deliver temozolomide (TM) continuously in interstitial chemotherapy for glioma." | 3.77 | Temozolomide/PLGA microparticles: a new protocol for treatment of glioma in rats. ( Liu, JM; Yue, ZJ; Zhang, H; Zhang, YH, 2011) |
| " This study's objective was to utilise microdialysis to monitor levels of glucose, lactate, pyruvate, glutamate and glycerol in patients following surgery for intrinsic brain tumours, and to assess the concentration of growth factors, cytokines and other proteins involved in the pathogenesis of high-grade gliomas in vivo." | 3.76 | In vivo assessment of high-grade glioma biochemistry using microdialysis: a study of energy-related molecules, growth factors and cytokines. ( Carpenter, KL; Hutchinson, PJ; Marcus, HJ; Price, SJ, 2010) |
| "Temozolomide (TM) has anti-tumor activity in patients with malignant glioma." | 3.76 | Temozolomide/PLGA microparticles plus vatalanib inhibits tumor growth and angiogenesis in an orthotopic glioma model. ( Liu, JM; Tang, GS; Wang, Y; Yue, ZJ; Zhang, H; Zhang, YH, 2010) |
| "Transferrin (Tf), an iron-transporting serum glycoprotein, which binds to receptors expressed at the surface of most proliferating cells with particularly high expression on erythroblasts and cancer cells, was chosen as the ligand to develop BCNU-loaded biodegradable poly(D,L-lactic acid) nanoparticles (NPs) containing a ligand, which specifically binds to glioma cells, and their anti-tumor ability was evaluated using a C6 glioma model." | 3.75 | Growth inhibition against intracranial C6 glioma cells by stereotactic delivery of BCNU by controlled release from poly(D,L-lactic acid) nanoparticles. ( Albadany, A; Chang, J; Guo, Y; Kang, C; Li, Y; Pu, P; Sheng, J; Yu, S; Yuan, X; Zhang, Z; Zhong, Y, 2009) |
| "In an effort to develop new therapeutic strategies to treat malignant gliomas, we have designed poly (lactic-co-glycolic) acid (PLGA) microparticles that deliver imatinib mesylate, a small molecule tyrosine kinase inhibitor." | 3.75 | Local delivery of poly lactic-co-glycolic acid microspheres containing imatinib mesylate inhibits intracranial xenograft glioma growth. ( Ariel, G; Benny, O; Black, PM; Carroll, RS; Goren, E; Kim, SK; Machluf, M; Menon, LG; Stewman, C, 2009) |
| "The purpose of the present study was to develop implantable poly(D,L-lactide-co-glycolide) (PLGA) microparticles for continuous delivery of intact 3,4-dihydro-3-methyl-4-oxoimidazo[5,1-d]-as-tetrazine-8-carboxamide (temozolomide, TM) for about a 1-month period and to evaluate its cytotoxicity against Glioma C6 cancer cells." | 3.74 | Temozolomide/PLGA microparticles and antitumor activity against glioma C6 cancer cells in vitro. ( Gao, S; Zhang, H, 2007) |
| "Direct dialysis could be employed to achieve paclitaxel-loaded PLGA and PLA nanoparticles, which could be internalized by C6 glioma cells and enhance the cytotoxicity of paclitaxel because of its penetration to the cytoplasm and sustained release property." | 3.73 | Self-assembled biodegradable nanoparticles developed by direct dialysis for the delivery of paclitaxel. ( Wang, CH; Xie, J, 2005) |
| "Gliomas can display marked changes in the concentrations of energy metabolism molecules such as creatine (Cr), phosphocreatine (PCr) and lactate, as measured using magnetic resonance spectroscopy (MRS)." | 3.71 | Modeling of pathophysiological coupling between brain electrical activation, energy metabolism and hemodynamics: insights for the interpretation of intracerebral tumor imaging. ( Aubert, A; Benali, H; Costalat, R; Duffau, H, 2002) |
| " Spectroscopy is a reliable technique for grading of gliomas when N-acetyl-aspartate/choline and choline/creatine ratios and presence of lipids are used in combination." | 3.69 | Characterization of intracranial mass lesions with in vivo proton MR spectroscopy. ( Chhabra, DK; Gupta, RK; Jain, VK; Pandey, R; Poptani, H; Roy, R, 1995) |
| "The question as to whether glutamine and glucose are both required for optimal growth of glioma cells is studied through the role of these substrates on the metabolism of the cells." | 3.69 | Glucose and glutamine metabolism in C6 glioma cells studied by carbon 13 NMR. ( Canioni, P; Merle, M; Portais, JC; Voisin, P, 1996) |
| "We examined the effect of lactic acid on cultured human glioma cell lines expressing glial fibrillary acidic protein (GFAP), vimentin and neuron-specific enolase (NSE)." | 3.68 | Contrary effect of lactic acid on expression of neuron-specific enolase and glial fibrillary acidic protein in human glioma cells. ( Fukui, M; Kitamura, K; Kuramitsu, M; Nakamura, T; Sawa, H; Takeshita, I, 1990) |
| "Glioma is one of the most commonly occurring malignant brain cancers with high recurrence and mortality." | 1.72 | HSP90 facilitates stemness and enhances glycolysis in glioma cells. ( Chen, J; Hou, JF; Kang, X, 2022) |
| "Glioma is a common type of malignant brain tumour with high mortality and relapse rate." | 1.56 | Lactate induced up-regulation of KLHDC8A (Kelch domain-containing 8A) contributes to the proliferation, migration and apoptosis of human glioma cells. ( Chen, T; Lv, K; Yang, H; Zhu, X, 2020) |
| "High-grade gliomas are associated with poor prognosis." | 1.56 | Metabolic response patterns in brain microdialysis fluids and serum during interstitial cisplatin treatment of high-grade glioma. ( Antti, H; Asklund, T; Bergenheim, AT; Bergström, P; Björkblom, B; Johansson, M; Jonsson, P; Tabatabaei, P, 2020) |
| "IDH1 mutant gliomas have distinct metabolic and microenvironment characteristics compared with wild type gliomas." | 1.51 | Metabolic characterization of human IDH mutant and wild type gliomas using simultaneous pH- and oxygen-sensitive molecular MRI. ( Chakhoyan, A; Cloughesy, TF; Ellingson, BM; Everson, RG; Lai, A; Liau, LM; Mareninov, S; Nathanson, DA; Nghiemphu, PL; Pope, WB; Prins, RM; Raymond, C; Salamon, N; Yao, J; Yong, WH, 2019) |
| "Glioma is among the most formidable brain cancers due to location in the brain." | 1.46 | Cholera Toxin Subunit B Enabled Multifunctional Glioma-Targeted Drug Delivery. ( Chai, Z; Gao, B; Guan, J; Hu, X; Liu, J; Liu, X; Lu, W; Qian, J; Yang, Y; Zhan, C; Zhang, Z, 2017) |
| "High-grade gliomas are aggressive and intensely glycolytic tumors." | 1.46 | Evaluation of mitochondrial respiratory function in highly glycolytic glioma cells reveals low ADP phosphorylation in relation to oxidative capacity. ( Castilho, RF; Figueira, TR; Ignarro, RS; Rodrigues-Silva, E; Rogério, F; Ruas, JS; Siqueira-Santos, ES, 2017) |
| "Glioma is one of the most common types of brain tumors." | 1.46 | Assessment of alterations in X-ray irradiation-induced DNA damage of glioma cells by using proton nuclear magnetic resonance spectroscopy. ( Li, F; Li, H; Shi, W; Xu, Y; Yi, C; Zeng, Q, 2017) |
| "Metabolic imaging of brain tumors using (13)C Magnetic Resonance Spectroscopy (MRS) of hyperpolarized [1-(13)C] pyruvate is a promising neuroimaging strategy which, after a decade of preclinical success in glioblastoma (GBM) models, is now entering clinical trials in multiple centers." | 1.43 | Hyperpolarized (13)C MR imaging detects no lactate production in mutant IDH1 gliomas: Implications for diagnosis and response monitoring. ( Blough, MD; Cairncross, JG; Chaumeil, MM; Chesnelong, C; Eriksson, P; Luchman, HA; Najac, C; Radoul, M; Ronen, SM; Viswanath, P, 2016) |
| " Systemically administered drugs are often poorly bioavailable in the brain, and drug efficacy within the central nervous system can be limited by peripheral toxicity." | 1.42 | Intravenous delivery of camptothecin-loaded PLGA nanoparticles for the treatment of intracranial glioma. ( Berens, ME; Chung, EP; Dhruv, HD; DiPerna, DM; Householder, KT; Sirianni, RW; Wohlleb, GM, 2015) |
| "It is very challenging to treat brain cancer because of the blood-brain barrier (BBB) restricting therapeutic drug or gene to access the brain." | 1.42 | Co-delivery of doxorubicin and siRNA for glioma therapy by a brain targeting system: angiopep-2-modified poly(lactic-co-glycolic acid) nanoparticles. ( Hao, Y; Li, D; Li, H; Meng, D; Shi, J; Wang, L; Zhang, H; Zhang, Y; Zhang, Z; Zhao, Y, 2015) |
| "Chaetocin-treated tumors exhibited heightened ROS, pATM, YAP1 and pJNK levels." | 1.40 | Chaetocin-induced ROS-mediated apoptosis involves ATM-YAP1 axis and JNK-dependent inhibition of glucose metabolism. ( Anto, NP; Dixit, D; Ghildiyal, R; Sen, E, 2014) |
| "Gliomas are resistant to radiation therapy, as well as to TNFα induced killing." | 1.39 | ATM-NFκB axis-driven TIGAR regulates sensitivity of glioma cells to radiomimetics in the presence of TNFα. ( Ghildiyal, R; Mehta, VS; Sen, E; Sinha, S, 2013) |
| "Etoposide (VP-16) is a hydrophobic anticancer agent inhibiting Topoisomerase II, commonly used in pediatric brain chemotherapeutic schemes as mildly toxic." | 1.39 | Etoposide encapsulation in surface-modified poly(lactide-co-glycolide) nanoparticles strongly enhances glioma antitumor efficiency. ( Andry, MC; Callewaert, M; Dukic, S; Gafa, V; Molinari, M; Roullin, VG; Van Gulick, L; Vittier, M, 2013) |
| "Monofocal acute inflammatory demyelination (MAID), which is observable by CT and MRI as a well-enhanced mass lesion with prominent perifocal edema, is very similar to malignant gliomas radiologically, making differential diagnosis of the two pathologies difficult." | 1.37 | Metabolic assessment of monofocal acute inflammatory demyelination using MR spectroscopy and (11)C-methionine-, (11)C-choline-, and (18)F-fluorodeoxyglucose-PET. ( Aki, T; Asano, Y; Ito, T; Iwama, T; Miwa, K; Shinoda, J; Takenaka, S; Yokoyama, K, 2011) |
| "Celecoxib was incorporated into poly DL-lactide-co-glycolide (PLGA) nanoparticles for antitumor drug delivery." | 1.37 | Preparation of polylactide-co-glycolide nanoparticles incorporating celecoxib and their antitumor activity against brain tumor cells. ( Jeong, YI; Jin, SG; Jung, S; Jung, TY; Kang, SS; Kim, IY; Kim, TH; Moon, KS; Pei, J, 2011) |
| "Using discriminant analysis, this study found that MR spectroscopy in combination with ADC ratio, rather than ADC value, can improve the ability to differentiate recurrent glioma and radiation injury." | 1.34 | Distinction between recurrent glioma and radiation injury using magnetic resonance spectroscopy in combination with diffusion-weighted imaging. ( Feng, DC; Li, CF; Liu, H; Zeng, QS; Zhen, JH, 2007) |
| "Paclitaxel was released from the nanoparticles in a biphasic profile with a fast release rate in the first 3 days followed by a slow first-order release." | 1.34 | Poly(D,L-lactide-co-glycolide) (PLGA) nanoparticles prepared by high pressure homogenization for paclitaxel chemotherapy. ( Dong, Y; Feng, SS, 2007) |
| "Gliomas are heterogeneous tumors with increased microvasculature, hypoxia, and necrosis." | 1.33 | Relationship of MR-derived lactate, mobile lipids, and relative blood volume for gliomas in vivo. ( Cha, S; Chang, SM; Crawford, F; Graves, EE; Li, X; Nelson, SJ; Vigneron, DB, 2005) |
| "Malignant gliomas are highly glycolytic and produce copious amounts of lactic acid, which is effluxed to the tumor microenvironment via lactate transporters." | 1.33 | Metabolic remodeling of malignant gliomas for enhanced sensitization during radiotherapy: an in vitro study. ( Colen, CB; Galloway, MP; Marples, B; Mathupala, SP; Seraji-Bozorgzad, N; Sloan, AE, 2006) |
| "Gliotoxins are a group of amino acids that are toxic to astrocytes, and are substrates of high-affinity sodium-dependent glutamate transporters." | 1.32 | Gliotoxins disrupt alanine metabolism and glutathione production in C6 glioma cells: a 13C NMR spectroscopic study. ( Brennan, L; Hewage, C; Malthouse, JP; McBean, GJ, 2004) |
| "Most of the brain tumors were characterized by strongly reduced total N-acetylaspartyl compounds and marked increases of myo-inositol and choline-containing compounds, consistent with a lack of neuroaxonal tissue and a proliferation of glial cells." | 1.31 | Quantitative proton magnetic resonance spectroscopy of focal brain lesions. ( Dechent, P; Frahm, J; Hanefeld, F; Herms, J; Markakis, E; Maxton, C; Wilken, B, 2000) |
| "The diagnosis of brain tumors after high-dose radiation therapy is frequently limited by the lack of metabolic discrimination available with conventional imaging methods." | 1.31 | Serial proton MR spectroscopic imaging of recurrent malignant gliomas after gamma knife radiosurgery. ( Chang, S; Dillon, WP; Graves, EE; Larson, D; McDermott, M; Nelson, SJ; Prados, MD; Verhey, L; Vigneron, DB, 2001) |
| "High-grade brain tumors are known to have a high rate of glucose (Glc) consumption." | 1.31 | High glycolytic activity in rat glioma demonstrated in vivo by correlation peak 1H magnetic resonance imaging. ( Décorps, M; Rémy, C; von Kienlin , M; Ziegler, A, 2001) |
| "Three epidermoid cysts showed only lactate signal." | 1.30 | In vivo single-voxel proton MR spectroscopy in intracranial cystic masses. ( Chang, KH; Han, MC; Han, MH; Jung, HW; Kim, HD; Kim, SH; Seong, SO; Song, IC, 1998) |
| "Choline signals were increased in tumour margins of high grade gliomas and more diffusely in low grade gliomas." | 1.29 | Localized proton spectroscopy of inoperable brain gliomas. Response to radiation therapy. ( Go, KG; Heesters, MA; Kamman, RL; Mooyaart, EL, 1993) |
| "Higher grades of brain tumors in this study were associated with higher Cho/reference and lower NAA/reference values." | 1.29 | Noninvasive evaluation of malignancy of brain tumors with proton MR spectroscopy. ( Arai, N; Fujiwara, S; Hara, K; Kayama, T; Kumabe, T; Ono, Y; Sato, K; Shimizu, H; Tominaga, T; Yoshimoto, T, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (1.01) | 18.7374 |
| 1990's | 31 (15.58) | 18.2507 |
| 2000's | 63 (31.66) | 29.6817 |
| 2010's | 85 (42.71) | 24.3611 |
| 2020's | 18 (9.05) | 2.80 |
| Authors | Studies |
|---|---|
| Obukhova, LМ | 1 |
| Nikiforova, ОN | 1 |
| Kopytova, ТV | 1 |
| Orlinskaya, NY | 1 |
| Kontorshchikov, ММ | 1 |
| Kontorshchikova, KN | 1 |
| Medyanik, IА | 1 |
| Grishin, АS | 1 |
| Vasina, DD | 1 |
| Wagner, W | 1 |
| Sobierajska, K | 1 |
| Kania, KD | 1 |
| Paradowska, E | 1 |
| Ciszewski, WM | 1 |
| Cherfils, L | 1 |
| Gatti, S | 1 |
| Guillevin, C | 3 |
| Miranville, A | 3 |
| Guillevin, R | 5 |
| Vaziri, S | 1 |
| Autry, AW | 1 |
| Lafontaine, M | 1 |
| Kim, Y | 1 |
| Gordon, JW | 1 |
| Chen, HY | 1 |
| Hu, JY | 1 |
| Lupo, JM | 2 |
| Chang, SM | 3 |
| Clarke, JL | 1 |
| Villanueva-Meyer, JE | 1 |
| Bush, NAO | 1 |
| Xu, D | 1 |
| Larson, PEZ | 2 |
| Vigneron, DB | 4 |
| Li, Y | 3 |
| Kang, X | 1 |
| Chen, J | 3 |
| Hou, JF | 1 |
| Sharma, S | 2 |
| Gowda, P | 2 |
| Lathoria, K | 2 |
| Mitra, MK | 1 |
| Sen, E | 4 |
| Ye, J | 1 |
| Xu, W | 1 |
| Xi, B | 1 |
| Wang, N | 1 |
| Chen, T | 2 |
| Sheng, Y | 2 |
| Yin, D | 1 |
| Zeng, Q | 3 |
| Maldonado, F | 1 |
| Fábregas, N | 1 |
| Aldecoa, I | 1 |
| González, J | 1 |
| García-Orellana, M | 1 |
| Belda, I | 1 |
| Hurtado, P | 1 |
| Gracia, I | 1 |
| de Riva, N | 1 |
| Tercero, J | 1 |
| Carrero, E | 1 |
| Valero, R | 1 |
| Branco, M | 1 |
| Linhares, P | 1 |
| Carvalho, B | 1 |
| Santos, P | 1 |
| Costa, BM | 1 |
| Vaz, R | 1 |
| Ni, W | 1 |
| Xia, Y | 1 |
| Luo, L | 1 |
| Wen, F | 1 |
| Hu, D | 1 |
| Bi, Y | 2 |
| Qi, J | 1 |
| Jiang, Q | 1 |
| Dong, X | 1 |
| Liu, J | 2 |
| Liu, L | 1 |
| Wang, H | 1 |
| Wang, L | 3 |
| Li, H | 6 |
| Yang, X | 1 |
| Dong, J | 1 |
| Björkblom, B | 1 |
| Jonsson, P | 1 |
| Tabatabaei, P | 1 |
| Bergström, P | 1 |
| Johansson, M | 1 |
| Asklund, T | 1 |
| Bergenheim, AT | 2 |
| Antti, H | 1 |
| Qu, C | 1 |
| Yan, C | 1 |
| Cao, W | 1 |
| Li, F | 3 |
| Qu, Y | 1 |
| Guan, K | 1 |
| Si, C | 1 |
| Yu, Z | 1 |
| Qu, Z | 1 |
| Datta, K | 1 |
| Lauritzen, MH | 1 |
| Merchant, M | 2 |
| Jang, T | 2 |
| Liu, SC | 2 |
| Hurd, R | 1 |
| Recht, L | 1 |
| Spielman, DM | 2 |
| Ding, C | 1 |
| Wu, Z | 1 |
| You, H | 1 |
| Ge, H | 1 |
| Zheng, S | 1 |
| Lin, Y | 1 |
| Wu, X | 1 |
| Lin, Z | 1 |
| Kang, D | 1 |
| Rich, LJ | 1 |
| Bagga, P | 1 |
| Wilson, NE | 1 |
| Schnall, MD | 1 |
| Detre, JA | 1 |
| Haris, M | 1 |
| Reddy, R | 1 |
| Zhu, X | 1 |
| Yang, H | 1 |
| Lv, K | 1 |
| Viswanath, P | 2 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Relationship of Anesthesia Method With Serum Lactate Level in Craniotomies[NCT05145049] | 110 participants (Actual) | Observational [Patient Registry] | 2021-11-01 | Completed | |||
| Study of Clinical Biomarkers in Human Health and Disease (Healthiomics)[NCT05106725] | 3,500 participants (Anticipated) | Observational | 2021-10-11 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for lactic acid and Glial Cell Tumors
| Article | Year |
|---|---|
The Acidic Brain-Glycolytic Switch in the Microenvironment of Malignant Glioma.
Topics: Animals; Brain; Brain Chemistry; Brain Neoplasms; Carbonic Anhydrases; Glioma; Glycolysis; Humans; H | 2021 |
3 Tesla magnetic resonance spectroscopy: cerebral gliomas vs. metastatic brain tumors. Our experience and review of the literature.
Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Diagnosis, Differ | 2013 |
Proton magnetic resonance spectroscopic evaluation of brain tumor metabolism.
Topics: Alanine; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Glioma; Glutamic Acid; Glutamine; Humans | 2004 |
New methods for direct delivery of chemotherapy for treating brain tumors.
Topics: Antineoplastic Agents; Biocompatible Materials; Brain Neoplasms; Clinical Trials as Topic; Drug Carr | 2006 |
2 trials available for lactic acid and Glial Cell Tumors
| Article | Year |
|---|---|
Prospective serial proton MR spectroscopic assessment of response to tamoxifen for recurrent malignant glioma.
Topics: Adult; Aged; Antineoplastic Agents, Hormonal; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Dis | 2008 |
The origin of lactate in peritumoral edema as measured by proton-magnetic resonance spectroscopic imaging.
Topics: Brain Edema; Brain Neoplasms; Glioma; Humans; Lactic Acid; Magnetic Resonance Spectroscopy; Protons | 1997 |
193 other studies available for lactic acid and Glial Cell Tumors
| Article | Year |
|---|---|
Relationship of Carbohydrate Metabolism and Molecular Genetic Markers in Gliomas with Different Degree of Anaplasia.
Topics: Adult; Anaplasia; Biomarkers, Tumor; Brain Chemistry; Brain Neoplasms; Carbohydrate Metabolism; DNA | 2021 |
Lactate Suppresses Retroviral Transduction in Cervical Epithelial Cells through DNA-PKcs Modulation.
Topics: Benzoates; Butyric Acid; Cell Line, Tumor; Cell Nucleus; Chromones; DNA-Activated Protein Kinase; Fe | 2021 |
On a tumor growth model with brain lactate kinetics.
Topics: Brain; Glioma; Humans; Kinetics; Lactic Acid; Models, Theoretical | 2022 |
Assessment of higher-order singular value decomposition denoising methods on dynamic hyperpolarized [1-
Topics: Bicarbonates; Glioma; Humans; Lactic Acid; Magnetic Resonance Imaging; Pyruvic Acid | 2022 |
HSP90 facilitates stemness and enhances glycolysis in glioma cells.
Topics: Adenosine Triphosphate; Animals; Cell Line, Tumor; Glioma; Glucose; Glycolysis; Humans; Lactic Acid; | 2022 |
Dynamic modelling predicts lactate and IL-1β as interventional targets in metabolic-inflammation-clock regulatory loop in glioma.
Topics: ARNTL Transcription Factors; Cytokines; Glioma; Humans; Inflammation; Lactic Acid | 2023 |
[Lactate-induced up-regulation of PLEKHA4 promotes proliferation and apoptosis of human glioma cells].
Topics: Animals; Apoptosis; beta Catenin; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Gene Expres | 2023 |
Using the metabolite alterations monitoring the AEG-1 expression level and cell biological behaviour of U251 cell in vitro.
Topics: Astrocytes; Choline; Gene Expression; Glioma; Humans; Lactic Acid; Oncogenes | 2023 |
Association between preoperative serum lactate concentrate with tumor cell proliferative index in primary brain tumor.
Topics: Brain Neoplasms; Cross-Sectional Studies; Glioma; Humans; Ki-67 Antigen; Lactic Acid; Meningeal Neop | 2022 |
Serum lactate levels are associated with glioma malignancy grade.
Topics: Adult; Aged; Biomarkers, Tumor; Brain Neoplasms; Glioma; Humans; Lactic Acid; Male; Middle Aged; Neo | 2019 |
High expression of ALDH1A3 might independently influence poor progression-free and overall survival in patients with glioma via maintaining glucose uptake and lactate production.
Topics: Adolescent; Adult; Aldehyde Oxidoreductases; Animals; Apoptosis; Biomarkers, Tumor; Brain Neoplasms; | 2020 |
3-Bromopyruvate inhibits the malignant phenotype of malignantly transformed macrophages and dendritic cells induced by glioma stem cells in the glioma microenvironment via miR-449a/MCT1.
Topics: Cell Transformation, Neoplastic; Cells, Cultured; Dendritic Cells; Glioma; Lactic Acid; Macrophages; | 2020 |
Metabolic response patterns in brain microdialysis fluids and serum during interstitial cisplatin treatment of high-grade glioma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Brain; Brain Neoplasms; Cisplatin; Female; Gl | 2020 |
miR-128-3p contributes to mitochondrial dysfunction and induces apoptosis in glioma cells via targeting pyruvate dehydrogenase kinase 1.
Topics: Adenosine Triphosphate; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Gene Expre | 2020 |
Reversed metabolic reprogramming as a measure of cancer treatment efficacy in rat C6 glioma model.
Topics: Animals; Antineoplastic Agents, Immunological; Bicarbonates; Biomarkers; Brain; Brain Neoplasms; Gli | 2019 |
CircNFIX promotes progression of glioma through regulating miR-378e/RPN2 axis.
Topics: Adult; Aged; Animals; Biomarkers, Tumor; Cell Line, Tumor; Disease Models, Animal; Disease Progressi | 2019 |
Topics: Animals; Brain; Brain Mapping; Cell Line, Tumor; Diagnostic Imaging; gamma-Aminobutyric Acid; Gliobl | 2020 |
Lactate induced up-regulation of KLHDC8A (Kelch domain-containing 8A) contributes to the proliferation, migration and apoptosis of human glioma cells.
Topics: Apoptosis; Brain Neoplasms; Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Line, Tumor; Cell Move | 2020 |
Non-invasive assessment of telomere maintenance mechanisms in brain tumors.
Topics: Alanine; Animals; Biomarkers, Tumor; Brain Neoplasms; Carbon Isotopes; Cell Line, Tumor; Genetic Eng | 2021 |
Rewiring of Lactate-Interleukin-1β Autoregulatory Loop with Clock-Bmal1: a Feed-Forward Circuit in Glioma.
Topics: Antineoplastic Agents; ARNTL Transcription Factors; Cell Line, Tumor; Circadian Clocks; Cytokines; D | 2021 |
In silico gene expression analysis reveals glycolysis and acetate anaplerosis in IDH1 wild-type glioma and lactate and glutamate anaplerosis in IDH1-mutated glioma.
Topics: Citric Acid Cycle; Computational Biology; Databases, Genetic; Gene Expression Regulation, Enzymologi | 2017 |
Age, choline-to-N-acetyl aspartate, and lipids-lactate-to-creatine ratios assemble a significant Cox's proportional-hazards regression model for survival prediction in patients with high-grade gliomas.
Topics: Aspartic Acid; Brain Neoplasms; Choline; Creatine; Glioma; Humans; Lactic Acid; Lipids; Magnetic Res | 2017 |
Evaluation of mitochondrial respiratory function in highly glycolytic glioma cells reveals low ADP phosphorylation in relation to oxidative capacity.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Cell Line, Tumor; Glioma; Glucose; Glycolysi | 2017 |
Effects of curcumin-loaded PLGA nanoparticles on the RG2 rat glioma model.
Topics: Animals; Curcumin; Female; Glioma; Lactic Acid; Nanoparticles; Polyglycolic Acid; Polylactic Acid-Po | 2017 |
Monocarboxylate transporter 1 is a key player in glioma-endothelial cell crosstalk.
Topics: Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Culture Med | 2017 |
Cholera Toxin Subunit B Enabled Multifunctional Glioma-Targeted Drug Delivery.
Topics: Animals; Blood-Brain Barrier; Cell Line, Tumor; Cholera Toxin; Drug Delivery Systems; Glioma; Human | 2017 |
Mammalian target of rapamycin complex 1 activation sensitizes human glioma cells to hypoxia-induced cell death.
Topics: Cell Death; Cell Hypoxia; Cell Line, Tumor; DNA Modification Methylases; DNA Repair Enzymes; Glioma; | 2017 |
A novel small molecule inhibitor of p32 mitochondrial protein overexpressed in glioma.
Topics: Amino Acid Sequence; Brain Neoplasms; Carrier Proteins; Cell Line, Tumor; Cell Proliferation; Fluore | 2017 |
Suppression of oxidative phosphorylation confers resistance against bevacizumab in experimental glioma.
Topics: Animals; Antimetabolites; Antineoplastic Agents, Immunological; Bevacizumab; Brain Neoplasms; Cell D | 2018 |
Online
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Disease Models, Animal; Female; Glioma; Lactic Acid | 2018 |
Development of a novel morphological paclitaxel-loaded PLGA microspheres for effective cancer therapy: in vitro and in vivo evaluations.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Cell Survival; Delayed-Acti | 2018 |
Micelle-templated, poly(lactic-
Topics: Cell Line, Tumor; Dexamethasone; Drug Carriers; Drug Delivery Systems; Drug Liberation; Emulsions; E | 2018 |
Delivery of Proapoptotic Agents in Glioma Cell Lines by TSPO Ligand-Dextran Nanogels.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cells, Cultured; Dextrans; Drug Carrier | 2018 |
Measuring the lactate-to-creatine ratio via
Topics: Apoptosis; Brain Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Creatine; DNA Damage; Electrop | 2018 |
Isocitrate dehydrogenase 1-mutated human gliomas depend on lactate and glutamate to alleviate metabolic stress.
Topics: 4-Aminobutyrate Transaminase; Animals; Brain Neoplasms; Gene Expression Profiling; Gene Expression R | 2019 |
Spatially Resolved Bioenergetic and Genetic Reprogramming Through the Brain of Rats Bearing Implanted C6 Gliomas As Detected by Multinuclear High-Resolution Magic Angle Spinning and Genomic Analysis.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Biopsy; Brain Neoplasms; Carbon Isotopes; Cau | 2018 |
Mesenchymal stem cells loaded with paclitaxel-poly(lactic-
Topics: Adipogenesis; Animals; Antineoplastic Agents; Cell Cycle; Cell Death; Cell Line, Tumor; Cell Movemen | 2018 |
Analysis of a mathematical model for brain lactate kinetics.
Topics: Brain; Brain Neoplasms; Capillaries; Computer Simulation; Energy Metabolism; Glioma; Humans; Intrace | 2018 |
Development of Nanoparticles for Drug Delivery to Brain Tumor: The Effect of Surface Materials on Penetration Into Brain Tissue.
Topics: Animals; Antineoplastic Agents; Brain; Brain Neoplasms; Cell Line, Tumor; Drug Carriers; Drug Delive | 2019 |
Mathematical Modeling of Substrates Fluxes and Tumor Growth in the Brain.
Topics: Brain; Cerebrovascular Circulation; Computer Simulation; Energy Metabolism; Glioma; Glucose; Humans; | 2019 |
Metabolic characterization of human IDH mutant and wild type gliomas using simultaneous pH- and oxygen-sensitive molecular MRI.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Brain Neoplasms; Echo-Planar Imaging; Female; Glioma; Gl | 2019 |
A genetically encoded FRET lactate sensor and its use to detect the Warburg effect in single cancer cells.
Topics: Animals; Biological Transport; Biosensing Techniques; DNA-Binding Proteins; Escherichia coli Protein | 2013 |
The influence of surface nanoroughness of electrospun PLGA nanofibrous scaffold on nerve cell adhesion and proliferation.
Topics: Biocompatible Materials; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Electrochemistry; Equi | 2013 |
ATM-NFκB axis-driven TIGAR regulates sensitivity of glioma cells to radiomimetics in the presence of TNFα.
Topics: Adenosine Triphosphate; Antibiotics, Antineoplastic; Apoptosis; Apoptosis Regulatory Proteins; Ataxi | 2013 |
Caloric restriction reduces edema and prolongs survival in a mouse glioma model.
Topics: 3-Hydroxybutyric Acid; Animals; Brain Edema; Brain Neoplasms; Caloric Restriction; Cell Line, Tumor; | 2013 |
Nodal regulates energy metabolism in glioma cells by inducing expression of hypoxia-inducible factor 1α.
Topics: Adenosine Triphosphate; Blotting, Western; Brain Neoplasms; Energy Metabolism; Glioma; Glucose; Glyc | 2013 |
Transferrin modified PEG-PLA-resveratrol conjugates: in vitro and in vivo studies for glioma.
Topics: Animals; Antineoplastic Agents; Apoptosis; Biological Transport; Brain; Cell Line, Tumor; Cell Proli | 2013 |
Lactate-modulated induction of THBS-1 activates transforming growth factor (TGF)-beta2 and migration of glioma cells in vitro.
Topics: Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Movement; Cell Proliferation; Enzyme-Linked Imm | 2013 |
Translocator protein ligand-PLGA conjugated nanoparticles for 5-fluorouracil delivery to glioma cancer cells.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Calorimetry, Differential Scanning; Carrier Proteins; Ce | 2014 |
iNGR-modified PEG-PLGA nanoparticles that recognize tumor vasculature and penetrate gliomas.
Topics: Administration, Intravenous; Animals; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Collage | 2014 |
Chaetocin-induced ROS-mediated apoptosis involves ATM-YAP1 axis and JNK-dependent inhibition of glucose metabolism.
Topics: Adaptor Proteins, Signal Transducing; Adenosine Triphosphate; Animals; Antineoplastic Agents; Apopto | 2014 |
Surface-coated PLA nanoparticles loaded with temozolomide for improved brain deposition and potential treatment of gliomas: development, characterization and in vivo studies.
Topics: Animals; Brain; Cell Line; Cell Line, Tumor; Dacarbazine; Dogs; Drug Carriers; Drug Delivery Systems | 2016 |
Proton T2 measurement and quantification of lactate in brain tumors by MRS at 3 Tesla in vivo.
Topics: Adult; Aged; Artifacts; Aspartic Acid; Brain Chemistry; Brain Neoplasms; Choline; Creatine; Female; | 2015 |
Efficacy of intratumoral chemotherapy using arsenic trioxide (As2O3) sustained release tablets for the treatment of neurogliocytoma in nude mice.
Topics: Animals; Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Brain Neoplasms; Delayed-Ac | 2014 |
A new magnetic resonance imaging contrast agent loaded into poly(lacide-co-glycolide) nanoparticles for long-term detection of tumors.
Topics: Animals; Cell Line, Tumor; Cell Survival; Contrast Media; Gadolinium; Glioma; Lactic Acid; Magnetic | 2014 |
Hypoxia enhances antitumor activity of dichloroacetate.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Cell | 2014 |
Intravenous delivery of camptothecin-loaded PLGA nanoparticles for the treatment of intracranial glioma.
Topics: Animals; Antineoplastic Agents, Phytogenic; Blood-Brain Barrier; Brain Neoplasms; Camptothecin; Drug | 2015 |
miR-495 mediates metabolic shift in glioma cells via targeting Glut1.
Topics: 3' Untranslated Regions; Cell Line, Tumor; Cell Proliferation; Cell Survival; Glioma; Glucose; Gluco | 2015 |
Co-delivery of doxorubicin and siRNA for glioma therapy by a brain targeting system: angiopep-2-modified poly(lactic-co-glycolic acid) nanoparticles.
Topics: Animals; Apoptosis; Brain; Brain Neoplasms; Cell Line, Tumor; Doxorubicin; Drug Combinations; Glioma | 2015 |
Monitoring Tumor Targeting and Treatment Effects of IRDye 800CW and GX1-Conjugated Polylactic Acid Nanoparticles Encapsulating Endostar on Glioma by Optical Molecular Imaging.
Topics: Animals; Benzenesulfonates; Body Weight; Cell Line, Tumor; Drug Delivery Systems; Endostatins; Fluor | 2015 |
Targeted Imaging and Chemo-Phototherapy of Brain Cancer by a Multifunctional Drug Delivery System.
Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Docetaxel; Drug Delivery Systems; Glioma; Humans; Lactic | 2015 |
XBP1 silencing decreases glioma cell viability and glycolysis possibly by inhibiting HK2 expression.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Cell Proliferation; DNA-Binding Proteins; Female; Gene S | 2016 |
Hyperpolarized (13)C-lactate to (13)C-bicarbonate ratio as a biomarker for monitoring the acute response of anti-vascular endothelial growth factor (anti-VEGF) treatment.
Topics: Animals; Bicarbonates; Biomarkers, Tumor; Brain Neoplasms; Carbon Isotopes; Cell Count; Cell Prolife | 2016 |
Hyperpolarized (13)C MR imaging detects no lactate production in mutant IDH1 gliomas: Implications for diagnosis and response monitoring.
Topics: Biomarkers, Tumor; Brain Neoplasms; Carbon-13 Magnetic Resonance Spectroscopy; Glioma; Humans; Isoci | 2016 |
A rapid inversion technique for the measurement of longitudinal relaxation times of brain metabolites: application to lactate in high-grade gliomas at 3 T.
Topics: Algorithms; Biomarkers, Tumor; Brain Neoplasms; Glioma; Humans; Image Enhancement; Image Interpretat | 2016 |
miRNA-451 inhibits glioma cell proliferation and invasion by downregulating glucose transporter 1.
Topics: Animals; Apoptosis; Biomarkers, Tumor; Blotting, Western; Cell Movement; Cell Proliferation; Fluores | 2016 |
Advanced interstitial chemotherapy combined with targeted treatment of malignant glioma in rats by using drug-loaded nanofibrous membranes.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bibenzyls; Brain; Brain Neoplasms; Camptoth | 2016 |
Choline-to-N-acetyl aspartate and lipids-lactate-to-creatine ratios together with age assemble a significant Cox's proportional-hazards regression model for prediction of survival in high-grade gliomas.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Biomarkers; Brain Neoplasms; Choline; Cre | 2016 |
Dual-Targeting Magnetic PLGA Nanoparticles for Codelivery of Paclitaxel and Curcumin for Brain Tumor Therapy.
Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Curcumin; Drug Delivery Systems; Glioma; Lactic Acid; Mi | 2016 |
Targeted delivery of nano-PTX to the brain tumor-associated macrophages.
Topics: Animals; Antineoplastic Agents; Blood-Brain Barrier; Brain Neoplasms; Capillary Permeability; Cell L | 2017 |
pH, Lactate, and Hypoxia: Reciprocity in Regulating High-Affinity Monocarboxylate Transporter Expression in Glioblastoma.
Topics: Astrocytes; Cell Hypoxia; Cell Line, Tumor; Cells, Cultured; Gene Expression; Gene Expression Regula | 2017 |
Assessment of alterations in X-ray irradiation-induced DNA damage of glioma cells by using proton nuclear magnetic resonance spectroscopy.
Topics: Apoptosis; Astrocytes; Brain Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Survival; Choline; Creati | 2017 |
Cerebral metabolism during air transport of patients after surgery for malignant glioma.
Topics: Air Ambulances; Brain; Brain Neoplasms; Glioma; Glucose; Glutamic Acid; Glycerol; Humans; Lactic Aci | 2008 |
Growth inhibition against intracranial C6 glioma cells by stereotactic delivery of BCNU by controlled release from poly(D,L-lactic acid) nanoparticles.
Topics: Animals; Brain Neoplasms; Carmustine; Cell Line, Tumor; Glioma; Lactic Acid; Male; Nanoparticles; Po | 2009 |
Local delivery of poly lactic-co-glycolic acid microspheres containing imatinib mesylate inhibits intracranial xenograft glioma growth.
Topics: Animals; Benzamides; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Glioma; Humans; Imatinib Mesy | 2009 |
Peripheral benzodiazepine receptor ligand-PLGA polymer conjugates potentially useful as delivery systems of apoptotic agents.
Topics: Acetamides; Animals; Antineoplastic Agents; Brain Neoplasms; Bridged Bicyclo Compounds, Heterocyclic | 2009 |
Redox dependence and compartmentation of [13C]pyruvate in the brain of deuterated rats bearing implanted C6 gliomas.
Topics: Animals; Astrocytes; Brain Chemistry; Brain Neoplasms; Carbon Isotopes; Cell Line, Tumor; Cerebral C | 2009 |
Paclitaxel-loaded PLGA nanoparticles surface modified with transferrin and Pluronic((R))P85, an in vitro cell line and in vivo biodistribution studies on rat model.
Topics: Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B; Cell Line | 2009 |
In vivo assessment of high-grade glioma biochemistry using microdialysis: a study of energy-related molecules, growth factors and cytokines.
Topics: Adult; Aged; Antineoplastic Agents, Hormonal; Cytokines; Dexamethasone; Energy Metabolism; Female; G | 2010 |
Designing bioresorbable polyester matrices for controlled doxorubicin release in glioma therapy.
Topics: Animals; Antibiotics, Antineoplastic; Brain Neoplasms; Cerebrospinal Fluid; Chemistry, Pharmaceutica | 2009 |
Differential diagnosis between radiation necrosis and glioma progression using sequential proton magnetic resonance spectroscopy and methionine positron emission tomography.
Topics: Adolescent; Adult; Aged; Biomarkers; Brain; Brain Neoplasms; Carbon Radioisotopes; Choline; Diagnosi | 2009 |
Temozolomide/PLGA microparticles: a new protocol for treatment of glioma in rats.
Topics: Animals; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Dacarbazine; Glioma; In Situ Nick-End La | 2011 |
Development of transferrin functionalized poly(ethylene glycol)/poly(lactic acid) amphiphilic block copolymeric micelles as a potential delivery system targeting brain glioma.
Topics: Brain Neoplasms; Glioma; Humans; Lactic Acid; Micelles; Polyethylene Glycols; Transferrin | 2010 |
Implementation of 3 T lactate-edited 3D 1H MR spectroscopic imaging with flyback echo-planar readout for gliomas patients.
Topics: Adult; Biomarkers, Tumor; Brain Chemistry; Brain Neoplasms; Echo-Planar Imaging; Female; Glioma; Hum | 2011 |
Mesenchymal stem cells as cellular vehicles for delivery of nanoparticles to brain tumors.
Topics: Animals; Brain; Brain Neoplasms; Cell Differentiation; Cell Line, Tumor; Cell Membrane Permeability; | 2010 |
Temozolomide/PLGA microparticles plus vatalanib inhibits tumor growth and angiogenesis in an orthotopic glioma model.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protoc | 2010 |
Treatment of rat brain tumors using sustained-release of camptothecin from poly(lactic-co-glycolic acid) microspheres in a thermoreversible hydrogel.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Camptothecin; Cell Line, Tumor; Delayed-Action Prep | 2010 |
Antitumoral activity of camptothecin-loaded nanoparticles in 9L rat glioma model.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Animals; Antineoplastic Agents, Phytogenic; beta-Cyclodextrins; B | 2011 |
Mathematical modeling of energy metabolism and hemodynamics of WHO grade II gliomas using in vivo MR data.
Topics: Adolescent; Adult; Aged; Algorithms; Brain Neoplasms; Cerebrovascular Circulation; Child; Choline; F | 2011 |
Detecting response of rat C6 glioma tumors to radiotherapy using hyperpolarized [1- 13C]pyruvate and 13C magnetic resonance spectroscopic imaging.
Topics: Animals; Brain Neoplasms; Carbon Isotopes; Cell Line, Tumor; Contrast Media; Glioma; Lactic Acid; Ma | 2011 |
The spatial organization of proton and lactate transport in a rat brain tumor.
Topics: Animals; Biological Transport; Brain Neoplasms; Cells, Cultured; Glioma; Ion Transport; Lactic Acid; | 2011 |
Metabolic assessment of monofocal acute inflammatory demyelination using MR spectroscopy and (11)C-methionine-, (11)C-choline-, and (18)F-fluorodeoxyglucose-PET.
Topics: Brain Neoplasms; Carbon Radioisotopes; Choline; Creatine; Demyelinating Diseases; Diagnosis, Differe | 2011 |
Metabolic targeting of lactate efflux by malignant glioma inhibits invasiveness and induces necrosis: an in vivo study.
Topics: Animals; Antineoplastic Agents; Biological Transport; Brain Neoplasms; Cell Line, Tumor; Coumaric Ac | 2011 |
Aptamer-functionalized PEG-PLGA nanoparticles for enhanced anti-glioma drug delivery.
Topics: Animals; Aptamers, Nucleotide; Cell Proliferation; Drug Delivery Systems; Electrophoresis, Polyacryl | 2011 |
RNAi screening in glioma stem-like cells identifies PFKFB4 as a key molecule important for cancer cell survival.
Topics: Adenosine Triphosphate; Brain Neoplasms; Cell Death; Cell Survival; Gene Expression Regulation, Neop | 2012 |
Preparation of polylactide-co-glycolide nanoparticles incorporating celecoxib and their antitumor activity against brain tumor cells.
Topics: Acetone; Animals; Antineoplastic Agents; Brain Neoplasms; Celecoxib; Cell Line, Tumor; Cell Movement | 2011 |
Transferrin adsorption onto PLGA nanoparticles governs their interaction with biological systems from blood circulation to brain cancer cells.
Topics: Adsorption; Animals; Astrocytes; Blood-Brain Barrier; Brain Neoplasms; Capillary Permeability; Caveo | 2012 |
A mathematical model for the glucose-lactate metabolism of in vitro cancer cells.
Topics: Cell Line, Tumor; Colonic Neoplasms; Energy Metabolism; Female; Glioma; Glucose; Humans; Lactic Acid | 2012 |
The effect of temozolomide/poly(lactide-co-glycolide) (PLGA)/nano-hydroxyapatite microspheres on glioma U87 cells behavior.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Cell Line, Tumor; Dacarbazine; Drug Carriers; Durapati | 2012 |
3-Bromopyruvate antagonizes effects of lactate and pyruvate, synergizes with citrate and exerts novel anti-glioma effects.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Cell Survival; Citric Acid; D-Amino-Acid Oxidase; Elec | 2012 |
Improvement of survival in C6 rat glioma model by a sustained drug release from localized PLGA microspheres in a thermoreversible hydrogel.
Topics: Animals; Antineoplastic Agents, Phytogenic; Brain; Brain Neoplasms; Camptothecin; Cell Line, Tumor; | 2012 |
Development of a nanoparticle-based system for the delivery of retinoic acid into macrophages.
Topics: Animals; Biological Transport; Brain Neoplasms; Cell Line, Tumor; Chemical Precipitation; Chemistry, | 2012 |
Combination therapy of surgical tumor resection with implantation of a hydrogel containing camptothecin-loaded poly(lactic-co-glycolic acid) microspheres in a C6 rat glioma model.
Topics: Animals; Antineoplastic Agents, Phytogenic; Brain Neoplasms; Camptothecin; Cell Line, Tumor; Combine | 2012 |
Temozolomide loaded PLGA-based superparamagnetic nanoparticles for magnetic resonance imaging and treatment of malignant glioma.
Topics: Animals; Antineoplastic Agents, Alkylating; Biological Transport; Brain Neoplasms; Cell Line, Tumor; | 2012 |
Diclofenac inhibits lactate formation and efficiently counteracts local immune suppression in a murine glioma model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Marrow Cells; Brain Neoplasms; Cell Cycle Che | 2013 |
Methylglyoxal alters glucose metabolism and increases AGEs content in C6 glioma cells.
Topics: Cell Line, Tumor; Coloring Agents; Energy Metabolism; Glioma; Glucose; Glycation End Products, Advan | 2012 |
Etoposide encapsulation in surface-modified poly(lactide-co-glycolide) nanoparticles strongly enhances glioma antitumor efficiency.
Topics: Animals; Antineoplastic Agents, Phytogenic; Brain; Brain Neoplasms; Cell Line, Tumor; Cell Survival; | 2013 |
Intracellular NAD(H) levels control motility and invasion of glioma cells.
Topics: Blotting, Northern; Blotting, Western; Cell Movement; Gene Expression Regulation, Neoplastic; Glioma | 2013 |
On a minimal model for hemodynamics and metabolism of lactate: application to low grade glioma and therapeutic strategies.
Topics: Brain Neoplasms; Glioma; Hemodynamics; Humans; Lactic Acid; Magnetic Resonance Spectroscopy; Models, | 2013 |
Correlations between magnetic resonance spectroscopy and image-guided histopathology, with special attention to radiation necrosis.
Topics: Adult; Brain Neoplasms; Choline; Creatine; Diagnosis, Differential; Glioma; Humans; Lactic Acid; Lip | 2002 |
A new dynamic in vitro model for the multidimensional study of astrocyte-endothelial cell interactions at the blood-brain barrier.
Topics: Algorithms; Animals; Aorta; Astrocytes; Blood-Brain Barrier; Brain Neoplasms; Capillaries; Cattle; C | 2002 |
In regard to Tarnawski et al., IJROBP 2002;52:1271-1276.
Topics: Brain Neoplasms; Carcinoma, Squamous Cell; Female; Glioma; Humans; Hydrogen; Lactic Acid; Luminescen | 2002 |
Pyruvate reverses metabolic effects produced by hypoxia in glioma and hepatoma cell cultures.
Topics: Animals; Carcinoma, Hepatocellular; Cell Hypoxia; Cell Line, Tumor; Glioma; Glucose; Humans; Hypoxia | 2002 |
Combination of single-voxel proton MR spectroscopy and apparent diffusion coefficient calculation in the evaluation of common brain tumors.
Topics: Adolescent; Adult; Aged; Alanine; Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Choline; Creat | 2003 |
Metabolism of [1-13C] glucose in extracts and in immobilized rat glioma C6 cell cultures: effects of hypoxia.
Topics: Animals; Carbon Isotopes; Cell Extracts; Cell Hypoxia; Glioma; Glucose; Lactic Acid; Rats; Tumor Cel | 2003 |
Modeling of pathophysiological coupling between brain electrical activation, energy metabolism and hemodynamics: insights for the interpretation of intracerebral tumor imaging.
Topics: Adenosine Triphosphate; Blood-Brain Barrier; Brain Neoplasms; Cerebrovascular Circulation; Energy Me | 2002 |
Correlation between the occurrence of 1H-MRS lipid signal, necrosis and lipid droplets during C6 rat glioma development.
Topics: Animals; Cell Line, Tumor; Female; Glioma; Humans; Inclusion Bodies; Lactic Acid; Lipid Metabolism; | 2003 |
A chemometric approach for brain tumor classification using magnetic resonance imaging and spectroscopy.
Topics: Aspartic Acid; Brain; Brain Chemistry; Brain Neoplasms; Cerebrospinal Fluid; Choline; Creatine; Disc | 2003 |
Gliotoxins disrupt alanine metabolism and glutathione production in C6 glioma cells: a 13C NMR spectroscopic study.
Topics: Alanine; Alanine Transaminase; Brain Neoplasms; Cell Line, Tumor; Dicarboxylic Acids; Enzyme Inhibit | 2004 |
Multi-spin-echo J-resolved spectroscopic imaging without water suppression: application to a rat glioma at 7 T.
Topics: Algorithms; Animals; Biomarkers, Tumor; Brain Neoplasms; Diagnosis, Computer-Assisted; Female; Gliom | 2004 |
Central neurogenic hyperventilation and lactate production in brainstem glioma.
Topics: Adult; Brain Stem Neoplasms; Female; Glioma; Humans; Hyperventilation; Lactic Acid | 2005 |
Clinicopathological examination of glioma by proton magnetic resonance spectroscopy background.
Topics: Adult; Aspartic Acid; Brain Neoplasms; Choline; Female; Glioma; Humans; Lactic Acid; Magnetic Resona | 2004 |
In vitro study of anticancer drug doxorubicin in PLGA-based microparticles.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Coated Material | 2005 |
Relationship of MR-derived lactate, mobile lipids, and relative blood volume for gliomas in vivo.
Topics: Blood Volume; Brain Neoplasms; Glioma; Humans; Lactic Acid; Lipids; Magnetic Resonance Spectroscopy; | 2005 |
Longitudinal multivoxel MR spectroscopy study of pediatric diffuse brainstem gliomas treated with radiotherapy.
Topics: Aspartic Acid; Brain Stem Neoplasms; Child; Child, Preschool; Choline; Creatine; Disease Progression | 2005 |
Non-invasive quantification of lactate by proton MR spectroscopy and its clinical applications.
Topics: Adult; Aged; Body Water; Brain Infarction; Brain Neoplasms; Female; Glioma; Humans; Lactic Acid; Lym | 2005 |
Self-assembled biodegradable nanoparticles developed by direct dialysis for the delivery of paclitaxel.
Topics: Antineoplastic Agents, Phytogenic; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Chemistry, Phar | 2005 |
A fast and sensitive 1H NMR method to measure the turnover of the H2 hydrogen of lactate.
Topics: Algorithms; Animals; Cell Line, Tumor; Computer Systems; Glioma; Hydrogen; Lactic Acid; Magnetic Res | 2005 |
Multisection 1H magnetic resonance spectroscopic imaging assessment of glioma response to chemotherapy.
Topics: Adult; Antineoplastic Agents; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Disease-Free Surviv | 2006 |
Glucose metabolism heterogeneity in human and mouse malignant glioma cell lines.
Topics: Amino Acid Sequence; Animals; Cell Hypoxia; Cell Survival; Electron Transport; Glioma; Glucose; Glyc | 2005 |
Independent component analysis to proton spectroscopic imaging data of human brain tumours.
Topics: Algorithms; Aspartic Acid; Astrocytoma; Brain Neoplasms; Cell Proliferation; Choline; Creatine; Glio | 2005 |
Development of new polymer-based particulate systems for anti-glioma vaccination.
Topics: Animals; Antigens, Neoplasm; Cancer Vaccines; Cell Line, Tumor; Chemistry, Pharmaceutical; Drug Carr | 2006 |
Development and characterization of interleukin-18-loaded biodegradable microspheres.
Topics: Absorbable Implants; Animals; Antineoplastic Agents; Cells, Cultured; Drug Carriers; Drug Implants; | 2006 |
Multiparametric 3T MR approach to the assessment of cerebral gliomas: tumor extent and malignancy.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain Neoplasms; Choline; Contrast Media; Creatine; Diffusio | 2006 |
Electrospun micro- and nanofibers for sustained delivery of paclitaxel to treat C6 glioma in vitro.
Topics: Antineoplastic Agents, Phytogenic; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Chemical Phenom | 2006 |
Differential mechanisms of radiosensitization by 2-deoxy-D-glucose in the monolayers and multicellular spheroids of a human glioma cell line.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Ch | 2006 |
BCNU-loaded PEG-PLLA ultrafine fibers and their in vitro antitumor activity against Glioma C6 cells.
Topics: Animals; Antineoplastic Agents, Alkylating; Carmustine; Cell Line, Tumor; Cell Survival; Drug Carrie | 2006 |
Temozolomide/PLGA microparticles and antitumor activity against glioma C6 cancer cells in vitro.
Topics: Animals; Antineoplastic Agents, Alkylating; Cell Line, Tumor; Dacarbazine; Drug Delivery Systems; Gl | 2007 |
Evaluation of particulate systems supporting tumor cell fractions in a preventive vaccination against intracranial rat glioma.
Topics: Animals; Antigens, Neoplasm; Biocompatible Materials; Brain Neoplasms; Cancer Vaccines; Cell Fractio | 2006 |
Metabolic remodeling of malignant gliomas for enhanced sensitization during radiotherapy: an in vitro study.
Topics: Adaptation, Physiological; Apoptosis; Cell Line, Tumor; Cell Survival; Coumaric Acids; Dose-Response | 2006 |
Distinction between recurrent glioma and radiation injury using magnetic resonance spectroscopy in combination with diffusion-weighted imaging.
Topics: Adult; Aged; Aspartic Acid; Brain; Brain Neoplasms; Choline; Diagnosis, Differential; Diffusion Magn | 2007 |
Differential effects of PPARgamma agonists on the metabolic properties of gliomas and astrocytes.
Topics: Animals; Antineoplastic Agents; Astrocytes; Brain Neoplasms; Cell Death; Cell Line, Tumor; Cell Surv | 2007 |
Poly(D,L-lactide-co-glycolide) (PLGA) nanoparticles prepared by high pressure homogenization for paclitaxel chemotherapy.
Topics: Antineoplastic Agents, Phytogenic; Brain Neoplasms; Calorimetry, Differential Scanning; Cell Surviva | 2007 |
Fabrication and evaluation of microgrooved polymers as peripheral nerve conduits.
Topics: Actins; Animals; Animals, Newborn; Biocompatible Materials; Biodegradation, Environmental; Brain-Der | 2007 |
Serial in vivo spectroscopic nuclear magnetic resonance imaging of lactate and extracellular pH in rat gliomas shows redistribution of protons away from sites of glycolysis.
Topics: Animals; Glioma; Glucose; Glycolysis; Hydrogen-Ion Concentration; Lactic Acid; Male; Nuclear Magneti | 2007 |
Analysis of metabolic indices in regions of abnormal perfusion in patients with high-grade glioma.
Topics: Adult; Aged; Brain Neoplasms; Creatine; Female; Glioma; Humans; Lactic Acid; Magnetic Resonance Imag | 2007 |
Biodegradable microparticles and fiber fabrics for sustained delivery of cisplatin to treat C6 glioma in vitro.
Topics: Animals; Cell Death; Cell Survival; Cisplatin; Delayed-Action Preparations; Glioma; Lactic Acid; Mic | 2008 |
Intracellular volume of osmotically regulated C-6 glioma cells.
Topics: Animals; Cell Line; Extracellular Space; Glioma; Hybrid Cells; Lactates; Lactic Acid; Mice; Neurobla | 1982 |
Characterization of intracranial mass lesions with in vivo proton MR spectroscopy.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain; Brain Diseases; Brain Neoplasms; Child; Choline; Crea | 1995 |
Lactate transport in cultured glial cells.
Topics: Animals; Astrocytes; Cells, Cultured; Female; Glioma; Hydrogen-Ion Concentration; Kinetics; Lactates | 1995 |
Localised proton spectroscopy and spectroscopic imaging in cerebral gliomas, with comparison to positron emission tomography.
Topics: Aspartic Acid; Brain; Brain Chemistry; Brain Edema; Carbon Radioisotopes; Creatine; Deoxyglucose; Fl | 1995 |
Glucose stimulates IGF-I gene expression in C6 glioma cells.
Topics: Animals; Cell Division; Gene Expression; Glioma; Glucose; Insulin-Like Growth Factor I; Lactates; La | 1995 |
Regulation of intracellular pH in neuronal and glial tumour cells, studied by multinuclear NMR spectroscopy.
Topics: Animals; Basement Membrane; Biological Transport; Glioma; Hydrogen-Ion Concentration; Intracellular | 1994 |
Metabolic loss of deuterium from isotopically labeled glucose.
Topics: Animals; Brain Neoplasms; Carbon Isotopes; Cerebral Cortex; Deuterium; Gas Chromatography-Mass Spect | 1994 |
Measurement of amino acid metabolism derived from [1-13C]glucose in the rat brain using 13C magnetic resonance spectroscopy.
Topics: Amino Acids; Animals; Brain; Carbon Isotopes; Ethylnitrosourea; Glioma; Glucose; Lactates; Lactic Ac | 1994 |
Localized proton spectroscopy of inoperable brain gliomas. Response to radiation therapy.
Topics: Aspartic Acid; Brain Neoplasms; Choline; Glioma; Humans; Lactates; Lactic Acid; Magnetic Resonance I | 1993 |
Quantitative proton spectroscopy and histology of a canine brain tumor model.
Topics: Animals; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Dogs; Glioma; Lactates; Lactic Acid; Mag | 1993 |
[Anaerobic glycolysis in the culture of rat C6-glioma cells].
Topics: Animals; Glioma; Glucose; Glycolysis; Hydrogen-Ion Concentration; Lactates; Lactic Acid; Rats; Tumor | 1993 |
Phased spectroscopic images: application to the characterization of the 1H 1.3-ppm resonance in intracerebral tumors in the rat.
Topics: Animals; Brain; Brain Neoplasms; Fourier Analysis; Glioma; Lactates; Lactic Acid; Magnetic Resonance | 1993 |
Noninvasive evaluation of malignancy of brain tumors with proton MR spectroscopy.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Energy Metabolism; Femal | 1996 |
Swelling, intracellular acidosis, and damage of glial cells.
Topics: Acid-Base Equilibrium; Animals; Arachidonic Acid; Brain Damage, Chronic; Brain Edema; Brain Ischemia | 1996 |
High glycolysis in gliomas despite low hexokinase transcription and activity correlated to chromosome 10 loss.
Topics: Adenosine Triphosphate; Chromosome Deletion; Chromosomes, Human, Pair 10; Glioma; Glycolysis; Hexoki | 1996 |
Glucose and glutamine metabolism in C6 glioma cells studied by carbon 13 NMR.
Topics: Amino Acids; Animals; Carbon Isotopes; Cell Division; Culture Media; Glioma; Glucose; Glutamic Acid; | 1996 |
Relationships among lactate concentration, blood flow and histopathologic profiles in rat C6 glioma.
Topics: Animals; Brain Neoplasms; Glioma; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Neoplasm Trans | 1996 |
Effect of 6-aminonicotinamide on metabolism of astrocytes and C6-glioma cells.
Topics: 6-Aminonicotinamide; Adenosine Triphosphate; Animals; Animals, Newborn; Astrocytes; Brain Neoplasms; | 1997 |
Increased choline signal coinciding with malignant degeneration of cerebral gliomas: a serial proton magnetic resonance spectroscopy imaging study.
Topics: Adult; Aged; Aspartic Acid; Biomarkers, Tumor; Biopsy; Brain Neoplasms; Cell Transformation, Neoplas | 1997 |
In vivo single-voxel proton MR spectroscopy in intracranial cystic masses.
Topics: Adult; Amino Acids; Brain Abscess; Brain Diseases; Brain Neoplasms; Cysticercosis; Cysts; Female; Ga | 1998 |
Adenosine, inosine, and guanosine protect glial cells during glucose deprivation and mitochondrial inhibition: correlation between protection and ATP preservation.
Topics: Adenine Nucleotides; Adenosine; Adenosine Triphosphate; Amobarbital; Anaerobiosis; Animals; Astrocyt | 1998 |
Modulation of VEGF production by pH and glucose in retinal Müller cells.
Topics: Animals; Brain Neoplasms; Cell Hypoxia; Cells, Cultured; Endothelial Growth Factors; Enzyme-Linked I | 1998 |
Compartmentation of lactate and glucose metabolism in C6 glioma cells. A 13c and 1H NMR study.
Topics: Aerobiosis; Carbon Isotopes; Cell Compartmentation; Clone Cells; Glioma; Glucose; Glycolysis; Lactic | 1998 |
Glucose and lactate metabolism in C6 glioma cells: evidence for the preferential utilization of lactate for cell oxidative metabolism.
Topics: Animals; Glioma; Glucose; Immunochemistry; Isoenzymes; L-Lactate Dehydrogenase; Lactic Acid; Oxidati | 1998 |
Lactate turnover in rat glioma measured by in vivo nuclear magnetic resonance spectroscopy.
Topics: Animals; Brain Neoplasms; Carbon Isotopes; Glioma; Glucose; Glutamic Acid; Glycolysis; Lactic Acid; | 1998 |
Comparison of different methods of intracerebral administration of radioiododeoxyuridine for glioma therapy using a rat model.
Topics: Animals; Brain Neoplasms; Coated Materials, Biocompatible; Drug Delivery Systems; Female; Glioma; Id | 2000 |
Contribution of anion transporters to the acidosis-induced swelling and intracellular acidification of glial cells.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Anions; Antiporters; Bicarbonates; Bumeta | 2000 |
Extracellular glutamate and other metabolites in and around RG2 rat glioma: an intracerebral microdialysis study.
Topics: Amino Acids; Animals; Ascorbic Acid; Brain Chemistry; Brain Neoplasms; Extracellular Space; Female; | 2000 |
Quantitative proton magnetic resonance spectroscopy of focal brain lesions.
Topics: Adolescent; Aspartic Acid; Biomarkers, Tumor; Brain; Brain Abscess; Brain Diseases; Brain Neoplasms; | 2000 |
In vivo study of tumor metabolism: an application of new multi-probe microdialysis system in the striatum of freely moving rats grafted with C6 cells.
Topics: Animals; Brain Neoplasms; Corpus Striatum; Glioma; Glucose; Lactic Acid; Male; Microdialysis; Pyruvi | 2000 |
Serial proton MR spectroscopic imaging of recurrent malignant gliomas after gamma knife radiosurgery.
Topics: Adult; Aspartic Acid; Brain; Brain Neoplasms; Choline; Energy Metabolism; Female; Follow-Up Studies; | 2001 |
Proton magnetic resonance chemical shift imaging (1H CSI)-directed stereotactic biopsy.
Topics: Adult; Aspartic Acid; Biopsy, Needle; Brain; Brain Neoplasms; Creatine; Diagnosis, Differential; Ene | 2001 |
Heterogeneity in 2-deoxy-D-glucose-induced modifications in energetics and radiation responses of human tumor cell lines.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Carcinoma, Squamous Cell; Deoxyglucose; DNA Damage; D | 2001 |
High glycolytic activity in rat glioma demonstrated in vivo by correlation peak 1H magnetic resonance imaging.
Topics: Alanine; Animals; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Ethanolamines; Female; Glioma; | 2001 |
Mapping extracellular pH in rat brain gliomas in vivo by 1H magnetic resonance spectroscopic imaging: comparison with maps of metabolites.
Topics: Animals; Aspartic Acid; Brain Neoplasms; Buffers; Choline; Contrast Media; Creatine; Extracellular S | 2001 |
Effect of exogenous lactate on rat glioma metabolism.
Topics: Animals; Blood Glucose; Brain; Brain Neoplasms; Carbon; Carbon Radioisotopes; Citric Acid Cycle; Ene | 2001 |
Improved analysis of 1H-MR spectra in the presence of mobile lipids.
Topics: Alanine; Artifacts; Brain; Brain Diseases; Brain Neoplasms; Glioblastoma; Glioma; Humans; Image Enha | 2001 |
Correlation between magnetic resonance spectroscopy imaging and image-guided biopsies: semiquantitative and qualitative histopathological analyses of patients with untreated glioma.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Dominance, Cerebr | 2001 |
Anti-cancer drug diffusion within living rat brain tissue: an experimental study using [3H](6)-5-fluorouracil-loaded PLGA microspheres.
Topics: Animals; Antineoplastic Agents; Biocompatible Materials; Brain; Brain Neoplasms; Contrast Media; Dif | 2002 |
Proton magnetic resonance spectroscopic imaging for metabolic characterization of demyelinating plaques.
Topics: Acute Disease; Adult; Aspartic Acid; Biopsy; Brain Chemistry; Brain Neoplasms; Choline; Creatine; De | 1992 |
In vivo imaging of glucose consumption and lactate concentration in human gliomas.
Topics: Adult; Brain Neoplasms; Deoxyglucose; Female; Fluorodeoxyglucose F18; Glioma; Glucose; Glycolysis; H | 1992 |
Spatially localized in vivo 1H magnetic resonance spectroscopy of an intracerebral rat glioma.
Topics: Animals; Aspartic Acid; Brain; Brain Neoplasms; Creatine; Female; Glioma; Hydrogen; Lactates; Lactic | 1992 |
Phosphorylation of pyruvate kinase and glycolytic metabolism in three human glioma cell lines.
Topics: Adenosine Triphosphate; Glioma; Glycolysis; Humans; Isoenzymes; L-Lactate Dehydrogenase; Lactates; L | 1991 |
The role of transmembrane pH gradients in the lactic acid induced swelling of astrocytes.
Topics: Alanine; Astrocytes; Brain Neoplasms; Cell Membrane; Dimethadione; Glioma; Humans; Hydrogen-Ion Conc | 1990 |
Contrary effect of lactic acid on expression of neuron-specific enolase and glial fibrillary acidic protein in human glioma cells.
Topics: Cell Line; Gene Expression Regulation, Neoplastic; Glial Fibrillary Acidic Protein; Glioma; Humans; | 1990 |
Noninvasive differentiation of tumors with use of localized H-1 MR spectroscopy in vivo: initial experience in patients with cerebral tumors.
Topics: Adult; Aspartic Acid; Brain Chemistry; Brain Diseases; Brain Neoplasms; Choline; Creatinine; Cysts; | 1989 |