Page last updated: 2024-10-17

lactic acid and Glaucoma

lactic acid has been researched along with Glaucoma in 18 studies

Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.

Glaucoma: An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function. The consequences of the increased pressure may be manifested in a variety of symptoms, depending upon type and severity, such as excavation of the optic disk, hardness of the eyeball, corneal anesthesia, reduced visual acuity, seeing of colored halos around lights, disturbed dark adaptation, visual field defects, and headaches. (Dictionary of Visual Science, 4th ed)

Research Excerpts

ExcerptRelevanceReference
"To evaluate the effect of a biodegradable microfilm with sustained release of prednisolone acetate (PA) on postoperative wound healing after experimental glaucoma filtration surgery (GFS)."7.77Evaluation of sustained release of PLC-loaded prednisolone acetate microfilm on postoperative inflammation in an experimental model of glaucoma filtration surgery. ( Ang, M; Foo, S; Venkatraman, SS; Wong, TT; Yan, P; Zhen, M, 2011)
"Ethacrynic acid (ECA) is a potential glaucoma drug that can reduce intraocular pressure."7.72Controlled release of ethacrynic acid from poly(lactide-co-glycolide) films for glaucoma treatment. ( Challa, P; Epstein, DL; Wang, Y; Yuan, F, 2004)
"Dorzolamide was ion paired with sodium dodecyl sulfate (SDS) and sodium oleate (SO) with 0."5.43Subconjunctival Delivery of Dorzolamide-Loaded Poly(ether-anhydride) Microparticles Produces Sustained Lowering of Intraocular Pressure in Rabbits. ( Fridley, C; Fu, J; Gedam, M; Hanes, J; Hu, Q; Liu, W; Liu, Y; Pitha, I; Quigley, HA; Sun, F, 2016)
"Poor drug penetration and rapid clearance after topical instillation of a drug formulation into the eyes are the major causes for the lower ocular bioavailability from conventional eye drops."5.40Dorzolamide-loaded PLGA/vitamin E TPGS nanoparticles for glaucoma therapy: Pharmacoscintigraphy study and evaluation of extended ocular hypotensive effect in rabbits. ( Ahmad, FJ; Anwar, M; Garg, V; Jain, GK; Khar, RK; Talegaonkar, S; Warsi, MH, 2014)
" We designed and developed a novel drug delivery system (DDS) comprising cyclosporine A (CsA) and poly(lactic-co-glycolic acid) (PLGA) based on a glaucoma drainage device (GDD) that can continuously release CsA to prevent postoperative fibrosis following glaucoma surgery."3.83Development of a novel CsA-PLGA drug delivery system based on a glaucoma drainage device for the prevention of postoperative fibrosis. ( Dai, Z; Hong, J; Liu, X; Sun, J; Sun, X; Yu, X, 2016)
"To evaluate the effect of a biodegradable microfilm with sustained release of prednisolone acetate (PA) on postoperative wound healing after experimental glaucoma filtration surgery (GFS)."3.77Evaluation of sustained release of PLC-loaded prednisolone acetate microfilm on postoperative inflammation in an experimental model of glaucoma filtration surgery. ( Ang, M; Foo, S; Venkatraman, SS; Wong, TT; Yan, P; Zhen, M, 2011)
"Ethacrynic acid (ECA) is a potential glaucoma drug that can reduce intraocular pressure."3.72Controlled release of ethacrynic acid from poly(lactide-co-glycolide) films for glaucoma treatment. ( Challa, P; Epstein, DL; Wang, Y; Yuan, F, 2004)
"The authors evaluated the effects of biodegradable poly (lactic acid) microspheres that provided the controlled release of the antimetabolic agent adriamycin (ADR) to prevent post surgical fibrosis after glaucoma filtering surgery."3.68Injectable microspheres with controlled drug release for glaucoma filtering surgery. ( Honda, Y; Hyon, SH; Ikada, Y; Kimura, H; Moritera, T; Ogura, Y; Wada, R, 1992)
" This need for frequent dosing with multiple medications makes compliance difficult."2.49Hybrid dendrimer hydrogel/poly(lactic-co-glycolic acid) nanoparticle platform: an advanced vehicle for topical delivery of antiglaucoma drugs and a likely solution to improving compliance and adherence in glaucoma management. ( Leffler, CT; Yang, H, 2013)
"Dorzolamide was ion paired with sodium dodecyl sulfate (SDS) and sodium oleate (SO) with 0."1.43Subconjunctival Delivery of Dorzolamide-Loaded Poly(ether-anhydride) Microparticles Produces Sustained Lowering of Intraocular Pressure in Rabbits. ( Fridley, C; Fu, J; Gedam, M; Hanes, J; Hu, Q; Liu, W; Liu, Y; Pitha, I; Quigley, HA; Sun, F, 2016)
"Poor drug penetration and rapid clearance after topical instillation of a drug formulation into the eyes are the major causes for the lower ocular bioavailability from conventional eye drops."1.40Dorzolamide-loaded PLGA/vitamin E TPGS nanoparticles for glaucoma therapy: Pharmacoscintigraphy study and evaluation of extended ocular hypotensive effect in rabbits. ( Ahmad, FJ; Anwar, M; Garg, V; Jain, GK; Khar, RK; Talegaonkar, S; Warsi, MH, 2014)
"Although antiscarring agents help prevent postsurgical scarring and improve glaucoma surgical outcomes, they may be associated with an increased incidence of severe and potentially blinding complications."1.39Effect of poly(DL-lactide-co-glycolide) on scar formation after glaucoma filtration surgery. ( DU, LQ; Li, Y; Wang, SG; Wu, XY; Yang, HL, 2013)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (16.67)18.2507
2000's2 (11.11)29.6817
2010's13 (72.22)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Vohra, R1
Dalgaard, LM1
Vibaek, J1
Langbøl, MA1
Bergersen, LH1
Olsen, NV1
Hassel, B1
Chaudhry, FA1
Kolko, M1
Ibrahim, MM1
Abd-Elgawad, AE1
Soliman, OA1
Jablonski, MM1
Turturro, S1
Sunoqrot, S1
Ying, H1
Hong, S1
Yue, BYJT1
Rodríguez-Agirretxe, I1
Vega, SC1
Rezola, R1
Vecino, E1
Mendicute, J1
Suarez-Cortes, T1
Acera, A1
DU, LQ1
Yang, HL1
Wu, XY1
Wang, SG1
Li, Y1
Warsi, MH1
Anwar, M1
Garg, V1
Jain, GK1
Talegaonkar, S1
Ahmad, FJ1
Khar, RK1
Dai, Z1
Yu, X1
Hong, J1
Liu, X1
Sun, J1
Sun, X1
Fu, J1
Sun, F1
Liu, W1
Liu, Y1
Gedam, M1
Hu, Q1
Fridley, C1
Quigley, HA1
Hanes, J1
Pitha, I1
Salama, HA1
Ghorab, M1
Mahmoud, AA1
Abdel Hady, M1
García-Caballero, C1
Prieto-Calvo, E1
Checa-Casalengua, P2
García-Martín, E1
Polo-Llorens, V1
García-Feijoo, J1
Molina-Martínez, IT2
Bravo-Osuna, I2
Herrero-Vanrell, R2
Schober, MS1
Chidlow, G1
Wood, JP1
Casson, RJ1
Jiang, C1
Tucker, BA1
Young, MJ1
Ang, M1
Yan, P1
Zhen, M1
Foo, S1
Venkatraman, SS1
Wong, TT1
Yang, H1
Leffler, CT1
Wang, Y1
Challa, P1
Epstein, DL1
Yuan, F1
Trope, GE1
Cheng, YL1
Sheardown, H1
Liu, GS1
Menon, IA1
Heathcote, JG1
Rootman, DS1
Chiu, WJ1
Gould, L1
Wang, G1
Tucker, IG1
Roberts, MS1
Hirst, LW1
Kimura, H1
Ogura, Y1
Moritera, T1
Honda, Y1
Wada, R1
Hyon, SH1
Ikada, Y1

Reviews

2 reviews available for lactic acid and Glaucoma

ArticleYear
Bioenergetic-based neuroprotection and glaucoma.
    Clinical & experimental ophthalmology, 2008, Volume: 36, Issue:4

    Topics: Animals; Calcium; Cell Death; Energy Metabolism; Free Radical Scavengers; Glaucoma; Glucose; Humans;

2008
Hybrid dendrimer hydrogel/poly(lactic-co-glycolic acid) nanoparticle platform: an advanced vehicle for topical delivery of antiglaucoma drugs and a likely solution to improving compliance and adherence in glaucoma management.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2013, Volume: 29, Issue:2

    Topics: Administration, Ophthalmic; Animals; Dendrimers; Drug Delivery Systems; Glaucoma; Humans; Hydrogel,

2013

Other Studies

16 other studies available for lactic acid and Glaucoma

ArticleYear
Potential metabolic markers in glaucoma and their regulation in response to hypoxia.
    Acta ophthalmologica, 2019, Volume: 97, Issue:6

    Topics: Aged; Amino Acids; Biomarkers; Blood Glucose; Chromatography, High Pressure Liquid; Female; Glaucoma

2019
Novel topical ophthalmic formulations for management of glaucoma.
    Pharmaceutical research, 2013, Volume: 30, Issue:11

    Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Brimonidine Tartrate; Glaucoma; Lactic Acid; Mice; Na

2013
Sustained release of matrix metalloproteinase-3 to trabecular meshwork cells using biodegradable PLGA microparticles.
    Molecular pharmaceutics, 2013, Aug-05, Volume: 10, Issue:8

    Topics: Glaucoma; Humans; In Vitro Techniques; Lactic Acid; Matrix Metalloproteinase 3; Microscopy, Electron

2013
The PLGA implant as an antimitotic delivery system after experimental trabeculectomy.
    Investigative ophthalmology & visual science, 2013, Aug-05, Volume: 54, Issue:8

    Topics: Animals; Antimitotic Agents; Coated Materials, Biocompatible; Conjunctiva; Disease Models, Animal; D

2013
Effect of poly(DL-lactide-co-glycolide) on scar formation after glaucoma filtration surgery.
    Chinese medical journal, 2013, Volume: 126, Issue:23

    Topics: Animals; Biocompatible Materials; Cicatrix; Filtering Surgery; Glaucoma; Lactic Acid; Polyglycolic A

2013
Dorzolamide-loaded PLGA/vitamin E TPGS nanoparticles for glaucoma therapy: Pharmacoscintigraphy study and evaluation of extended ocular hypotensive effect in rabbits.
    Colloids and surfaces. B, Biointerfaces, 2014, Oct-01, Volume: 122

    Topics: Animals; Carbonic Anhydrase Inhibitors; Glaucoma; Intraocular Pressure; Lactic Acid; Microscopy, Ele

2014
Development of a novel CsA-PLGA drug delivery system based on a glaucoma drainage device for the prevention of postoperative fibrosis.
    Materials science & engineering. C, Materials for biological applications, 2016, Sep-01, Volume: 66

    Topics: Animals; Cell Survival; Cells, Cultured; Chromatography, High Pressure Liquid; Cyclosporine; Drainag

2016
Subconjunctival Delivery of Dorzolamide-Loaded Poly(ether-anhydride) Microparticles Produces Sustained Lowering of Intraocular Pressure in Rabbits.
    Molecular pharmaceutics, 2016, 09-06, Volume: 13, Issue:9

    Topics: Animals; Antihypertensive Agents; Carbonic Anhydrase Inhibitors; Ethylamines; Female; Glaucoma; Intr

2016
PLGA Nanoparticles as Subconjunctival Injection for Management of Glaucoma.
    AAPS PharmSciTech, 2017, Volume: 18, Issue:7

    Topics: Animals; Conjunctiva; Drug Carriers; Drug Delivery Systems; Drug Liberation; Glaucoma; Intraocular P

2017
Six month delivery of GDNF from PLGA/vitamin E biodegradable microspheres after intravitreal injection in rabbits.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2017, May-30, Volume: 103

    Topics: Animals; Drug Carriers; Drug Liberation; Female; Glaucoma; Glial Cell Line-Derived Neurotrophic Fact

2017
Retinal ganglion cells survival in a glaucoma model by GDNF/Vit E PLGA microspheres prepared according to a novel microencapsulation procedure.
    Journal of controlled release : official journal of the Controlled Release Society, 2011, Nov-30, Volume: 156, Issue:1

    Topics: Animals; Cell Survival; Cells, Cultured; Disease Models, Animal; Drug Carriers; Drug Combinations; D

2011
Evaluation of sustained release of PLC-loaded prednisolone acetate microfilm on postoperative inflammation in an experimental model of glaucoma filtration surgery.
    Current eye research, 2011, Volume: 36, Issue:12

    Topics: Animals; Delayed-Action Preparations; Disease Models, Animal; Drug Carriers; Endophthalmitis; Female

2011
Controlled release of ethacrynic acid from poly(lactide-co-glycolide) films for glaucoma treatment.
    Biomaterials, 2004, Volume: 25, Issue:18

    Topics: Absorption; Animals; Delayed-Action Preparations; Diffusion; Drug Evaluation, Preclinical; Ethacryni

2004
Depot drug delivery system for 5-fluorouracil after filtration surgery in the rabbit.
    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 1994, Volume: 29, Issue:6

    Topics: Animals; Biocompatible Materials; Biodegradation, Environmental; Conjunctiva; Drug Delivery Systems;

1994
In vitro and in vivo evaluation in rabbits of a controlled release 5-fluorouracil subconjunctival implant based on poly(D,L-lactide-co-glycolide).
    Pharmaceutical research, 1996, Volume: 13, Issue:7

    Topics: Animals; Biocompatible Materials; Conjunctiva; Delayed-Action Preparations; Drug Implants; Fluoroura

1996
Injectable microspheres with controlled drug release for glaucoma filtering surgery.
    Investigative ophthalmology & visual science, 1992, Volume: 33, Issue:12

    Topics: Animals; Delayed-Action Preparations; Doxorubicin; Eye; Fibrosis; Glaucoma; Injections; Lactates; La

1992