lactic acid has been researched along with Glaucoma in 18 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Glaucoma: An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function. The consequences of the increased pressure may be manifested in a variety of symptoms, depending upon type and severity, such as excavation of the optic disk, hardness of the eyeball, corneal anesthesia, reduced visual acuity, seeing of colored halos around lights, disturbed dark adaptation, visual field defects, and headaches. (Dictionary of Visual Science, 4th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the effect of a biodegradable microfilm with sustained release of prednisolone acetate (PA) on postoperative wound healing after experimental glaucoma filtration surgery (GFS)." | 7.77 | Evaluation of sustained release of PLC-loaded prednisolone acetate microfilm on postoperative inflammation in an experimental model of glaucoma filtration surgery. ( Ang, M; Foo, S; Venkatraman, SS; Wong, TT; Yan, P; Zhen, M, 2011) |
| "Ethacrynic acid (ECA) is a potential glaucoma drug that can reduce intraocular pressure." | 7.72 | Controlled release of ethacrynic acid from poly(lactide-co-glycolide) films for glaucoma treatment. ( Challa, P; Epstein, DL; Wang, Y; Yuan, F, 2004) |
| "Dorzolamide was ion paired with sodium dodecyl sulfate (SDS) and sodium oleate (SO) with 0." | 5.43 | Subconjunctival Delivery of Dorzolamide-Loaded Poly(ether-anhydride) Microparticles Produces Sustained Lowering of Intraocular Pressure in Rabbits. ( Fridley, C; Fu, J; Gedam, M; Hanes, J; Hu, Q; Liu, W; Liu, Y; Pitha, I; Quigley, HA; Sun, F, 2016) |
| "Poor drug penetration and rapid clearance after topical instillation of a drug formulation into the eyes are the major causes for the lower ocular bioavailability from conventional eye drops." | 5.40 | Dorzolamide-loaded PLGA/vitamin E TPGS nanoparticles for glaucoma therapy: Pharmacoscintigraphy study and evaluation of extended ocular hypotensive effect in rabbits. ( Ahmad, FJ; Anwar, M; Garg, V; Jain, GK; Khar, RK; Talegaonkar, S; Warsi, MH, 2014) |
| " We designed and developed a novel drug delivery system (DDS) comprising cyclosporine A (CsA) and poly(lactic-co-glycolic acid) (PLGA) based on a glaucoma drainage device (GDD) that can continuously release CsA to prevent postoperative fibrosis following glaucoma surgery." | 3.83 | Development of a novel CsA-PLGA drug delivery system based on a glaucoma drainage device for the prevention of postoperative fibrosis. ( Dai, Z; Hong, J; Liu, X; Sun, J; Sun, X; Yu, X, 2016) |
| "To evaluate the effect of a biodegradable microfilm with sustained release of prednisolone acetate (PA) on postoperative wound healing after experimental glaucoma filtration surgery (GFS)." | 3.77 | Evaluation of sustained release of PLC-loaded prednisolone acetate microfilm on postoperative inflammation in an experimental model of glaucoma filtration surgery. ( Ang, M; Foo, S; Venkatraman, SS; Wong, TT; Yan, P; Zhen, M, 2011) |
| "Ethacrynic acid (ECA) is a potential glaucoma drug that can reduce intraocular pressure." | 3.72 | Controlled release of ethacrynic acid from poly(lactide-co-glycolide) films for glaucoma treatment. ( Challa, P; Epstein, DL; Wang, Y; Yuan, F, 2004) |
| "The authors evaluated the effects of biodegradable poly (lactic acid) microspheres that provided the controlled release of the antimetabolic agent adriamycin (ADR) to prevent post surgical fibrosis after glaucoma filtering surgery." | 3.68 | Injectable microspheres with controlled drug release for glaucoma filtering surgery. ( Honda, Y; Hyon, SH; Ikada, Y; Kimura, H; Moritera, T; Ogura, Y; Wada, R, 1992) |
| " This need for frequent dosing with multiple medications makes compliance difficult." | 2.49 | Hybrid dendrimer hydrogel/poly(lactic-co-glycolic acid) nanoparticle platform: an advanced vehicle for topical delivery of antiglaucoma drugs and a likely solution to improving compliance and adherence in glaucoma management. ( Leffler, CT; Yang, H, 2013) |
| "Dorzolamide was ion paired with sodium dodecyl sulfate (SDS) and sodium oleate (SO) with 0." | 1.43 | Subconjunctival Delivery of Dorzolamide-Loaded Poly(ether-anhydride) Microparticles Produces Sustained Lowering of Intraocular Pressure in Rabbits. ( Fridley, C; Fu, J; Gedam, M; Hanes, J; Hu, Q; Liu, W; Liu, Y; Pitha, I; Quigley, HA; Sun, F, 2016) |
| "Poor drug penetration and rapid clearance after topical instillation of a drug formulation into the eyes are the major causes for the lower ocular bioavailability from conventional eye drops." | 1.40 | Dorzolamide-loaded PLGA/vitamin E TPGS nanoparticles for glaucoma therapy: Pharmacoscintigraphy study and evaluation of extended ocular hypotensive effect in rabbits. ( Ahmad, FJ; Anwar, M; Garg, V; Jain, GK; Khar, RK; Talegaonkar, S; Warsi, MH, 2014) |
| "Although antiscarring agents help prevent postsurgical scarring and improve glaucoma surgical outcomes, they may be associated with an increased incidence of severe and potentially blinding complications." | 1.39 | Effect of poly(DL-lactide-co-glycolide) on scar formation after glaucoma filtration surgery. ( DU, LQ; Li, Y; Wang, SG; Wu, XY; Yang, HL, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (16.67) | 18.2507 |
| 2000's | 2 (11.11) | 29.6817 |
| 2010's | 13 (72.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vohra, R | 1 |
| Dalgaard, LM | 1 |
| Vibaek, J | 1 |
| Langbøl, MA | 1 |
| Bergersen, LH | 1 |
| Olsen, NV | 1 |
| Hassel, B | 1 |
| Chaudhry, FA | 1 |
| Kolko, M | 1 |
| Ibrahim, MM | 1 |
| Abd-Elgawad, AE | 1 |
| Soliman, OA | 1 |
| Jablonski, MM | 1 |
| Turturro, S | 1 |
| Sunoqrot, S | 1 |
| Ying, H | 1 |
| Hong, S | 1 |
| Yue, BYJT | 1 |
| Rodríguez-Agirretxe, I | 1 |
| Vega, SC | 1 |
| Rezola, R | 1 |
| Vecino, E | 1 |
| Mendicute, J | 1 |
| Suarez-Cortes, T | 1 |
| Acera, A | 1 |
| DU, LQ | 1 |
| Yang, HL | 1 |
| Wu, XY | 1 |
| Wang, SG | 1 |
| Li, Y | 1 |
| Warsi, MH | 1 |
| Anwar, M | 1 |
| Garg, V | 1 |
| Jain, GK | 1 |
| Talegaonkar, S | 1 |
| Ahmad, FJ | 1 |
| Khar, RK | 1 |
| Dai, Z | 1 |
| Yu, X | 1 |
| Hong, J | 1 |
| Liu, X | 1 |
| Sun, J | 1 |
| Sun, X | 1 |
| Fu, J | 1 |
| Sun, F | 1 |
| Liu, W | 1 |
| Liu, Y | 1 |
| Gedam, M | 1 |
| Hu, Q | 1 |
| Fridley, C | 1 |
| Quigley, HA | 1 |
| Hanes, J | 1 |
| Pitha, I | 1 |
| Salama, HA | 1 |
| Ghorab, M | 1 |
| Mahmoud, AA | 1 |
| Abdel Hady, M | 1 |
| García-Caballero, C | 1 |
| Prieto-Calvo, E | 1 |
| Checa-Casalengua, P | 2 |
| García-Martín, E | 1 |
| Polo-Llorens, V | 1 |
| García-Feijoo, J | 1 |
| Molina-Martínez, IT | 2 |
| Bravo-Osuna, I | 2 |
| Herrero-Vanrell, R | 2 |
| Schober, MS | 1 |
| Chidlow, G | 1 |
| Wood, JP | 1 |
| Casson, RJ | 1 |
| Jiang, C | 1 |
| Tucker, BA | 1 |
| Young, MJ | 1 |
| Ang, M | 1 |
| Yan, P | 1 |
| Zhen, M | 1 |
| Foo, S | 1 |
| Venkatraman, SS | 1 |
| Wong, TT | 1 |
| Yang, H | 1 |
| Leffler, CT | 1 |
| Wang, Y | 1 |
| Challa, P | 1 |
| Epstein, DL | 1 |
| Yuan, F | 1 |
| Trope, GE | 1 |
| Cheng, YL | 1 |
| Sheardown, H | 1 |
| Liu, GS | 1 |
| Menon, IA | 1 |
| Heathcote, JG | 1 |
| Rootman, DS | 1 |
| Chiu, WJ | 1 |
| Gould, L | 1 |
| Wang, G | 1 |
| Tucker, IG | 1 |
| Roberts, MS | 1 |
| Hirst, LW | 1 |
| Kimura, H | 1 |
| Ogura, Y | 1 |
| Moritera, T | 1 |
| Honda, Y | 1 |
| Wada, R | 1 |
| Hyon, SH | 1 |
| Ikada, Y | 1 |
2 reviews available for lactic acid and Glaucoma
| Article | Year |
|---|---|
Bioenergetic-based neuroprotection and glaucoma.
Topics: Animals; Calcium; Cell Death; Energy Metabolism; Free Radical Scavengers; Glaucoma; Glucose; Humans; | 2008 |
Hybrid dendrimer hydrogel/poly(lactic-co-glycolic acid) nanoparticle platform: an advanced vehicle for topical delivery of antiglaucoma drugs and a likely solution to improving compliance and adherence in glaucoma management.
Topics: Administration, Ophthalmic; Animals; Dendrimers; Drug Delivery Systems; Glaucoma; Humans; Hydrogel, | 2013 |
16 other studies available for lactic acid and Glaucoma
| Article | Year |
|---|---|
Potential metabolic markers in glaucoma and their regulation in response to hypoxia.
Topics: Aged; Amino Acids; Biomarkers; Blood Glucose; Chromatography, High Pressure Liquid; Female; Glaucoma | 2019 |
Novel topical ophthalmic formulations for management of glaucoma.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Brimonidine Tartrate; Glaucoma; Lactic Acid; Mice; Na | 2013 |
Sustained release of matrix metalloproteinase-3 to trabecular meshwork cells using biodegradable PLGA microparticles.
Topics: Glaucoma; Humans; In Vitro Techniques; Lactic Acid; Matrix Metalloproteinase 3; Microscopy, Electron | 2013 |
The PLGA implant as an antimitotic delivery system after experimental trabeculectomy.
Topics: Animals; Antimitotic Agents; Coated Materials, Biocompatible; Conjunctiva; Disease Models, Animal; D | 2013 |
Effect of poly(DL-lactide-co-glycolide) on scar formation after glaucoma filtration surgery.
Topics: Animals; Biocompatible Materials; Cicatrix; Filtering Surgery; Glaucoma; Lactic Acid; Polyglycolic A | 2013 |
Dorzolamide-loaded PLGA/vitamin E TPGS nanoparticles for glaucoma therapy: Pharmacoscintigraphy study and evaluation of extended ocular hypotensive effect in rabbits.
Topics: Animals; Carbonic Anhydrase Inhibitors; Glaucoma; Intraocular Pressure; Lactic Acid; Microscopy, Ele | 2014 |
Development of a novel CsA-PLGA drug delivery system based on a glaucoma drainage device for the prevention of postoperative fibrosis.
Topics: Animals; Cell Survival; Cells, Cultured; Chromatography, High Pressure Liquid; Cyclosporine; Drainag | 2016 |
Subconjunctival Delivery of Dorzolamide-Loaded Poly(ether-anhydride) Microparticles Produces Sustained Lowering of Intraocular Pressure in Rabbits.
Topics: Animals; Antihypertensive Agents; Carbonic Anhydrase Inhibitors; Ethylamines; Female; Glaucoma; Intr | 2016 |
PLGA Nanoparticles as Subconjunctival Injection for Management of Glaucoma.
Topics: Animals; Conjunctiva; Drug Carriers; Drug Delivery Systems; Drug Liberation; Glaucoma; Intraocular P | 2017 |
Six month delivery of GDNF from PLGA/vitamin E biodegradable microspheres after intravitreal injection in rabbits.
Topics: Animals; Drug Carriers; Drug Liberation; Female; Glaucoma; Glial Cell Line-Derived Neurotrophic Fact | 2017 |
Retinal ganglion cells survival in a glaucoma model by GDNF/Vit E PLGA microspheres prepared according to a novel microencapsulation procedure.
Topics: Animals; Cell Survival; Cells, Cultured; Disease Models, Animal; Drug Carriers; Drug Combinations; D | 2011 |
Evaluation of sustained release of PLC-loaded prednisolone acetate microfilm on postoperative inflammation in an experimental model of glaucoma filtration surgery.
Topics: Animals; Delayed-Action Preparations; Disease Models, Animal; Drug Carriers; Endophthalmitis; Female | 2011 |
Controlled release of ethacrynic acid from poly(lactide-co-glycolide) films for glaucoma treatment.
Topics: Absorption; Animals; Delayed-Action Preparations; Diffusion; Drug Evaluation, Preclinical; Ethacryni | 2004 |
Depot drug delivery system for 5-fluorouracil after filtration surgery in the rabbit.
Topics: Animals; Biocompatible Materials; Biodegradation, Environmental; Conjunctiva; Drug Delivery Systems; | 1994 |
In vitro and in vivo evaluation in rabbits of a controlled release 5-fluorouracil subconjunctival implant based on poly(D,L-lactide-co-glycolide).
Topics: Animals; Biocompatible Materials; Conjunctiva; Delayed-Action Preparations; Drug Implants; Fluoroura | 1996 |
Injectable microspheres with controlled drug release for glaucoma filtering surgery.
Topics: Animals; Delayed-Action Preparations; Doxorubicin; Eye; Fibrosis; Glaucoma; Injections; Lactates; La | 1992 |